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Zavedos Inj
Zavedos Inj
Idarubicin hydrochloride
ZAVEDOS® INJECTION 1 of 4
• infection or high temperature, How ZAVEDOS is ZAVEDOS lowers the number of
severe chills, sore throat or white blood cells and platelets in
mouth ulcers
given your blood. This means that you
have an increased chance of
• stomach ulcers, or vomiting ZAVEDOS injection will be
getting an infection or bleeding.
blood or bleeding from the prepared in a hospital and given
back passage. to you by a doctor or nurse. Medicines such as ZAVEDOS are
also known to affect the heart
ZAVEDOS is given as a slow particularly at high doses and
Taking other medicines intravenous injection, usually on after a long period of treatment.
Tell your doctor or pharmacist 3 consecutive days. If other
Regular tests to monitor your
if you are taking any other cancer medicines are to be given
blood count, kidney and liver
medicines, including any that in combination with ZAVEDOS,
function, and your heart will be
further days of treatment may be
you get without a prescription required before, during and after
involved. This is called an
from your pharmacy, treatment.
induction course.
supermarket or health food
shop. Tell your doctor immediately if
Another course of treatment may you or your partner becomes
be needed depending on your pregnant while you are taking
Some medicines and ZAVEDOS
response to treatment. Additional or just after you stop taking
may interfere with each other.
treatment will not be repeated ZAVEDOS.
These include:
until your blood returns to
acceptable levels and any Use a proven method of birth
• other medicines for cancer
unwanted effects have been control such as the
• some medicines for heart controlled. contraceptive pill or a condom
problems, including calcium while taking the medicine and
channel blockers, used to Inform your doctor or nurse for at least 12 weeks after
treat high blood pressure and immediately if pain, redness or stopping treatment.
angina. swelling develops at the
injection site. If you are about to be started
• certain medicines that may
on any new medicine, remind
affect your liver and kidney
your doctor, dentist or
function, e.g. some
antibiotics and antifungals If you are given too much pharmacist that you are being
(overdose) treated with ZAVEDOS.
• vaccines.
Overdose may result in nausea, If you are going to have
These medicines may increase vomiting and bleeding from the surgery, tell the surgeon,
some side effects of ZAVEDOS, stomach. anaesthetist or dentist that you
including the effects on the heart,
are using this medicine.
blood cells, the stomach or Very high doses of ZAVEDOS
bowels, and reduce the body’s may cause severe damage to the If any time before, during or
ability to fight infection. heart within 24 hours and may after treatment with
seriously affect the production of ZAVEDOS you experience any
If you are concerned about new red and white blood cells difficulties, consult your doctor.
taking any other medications within 1 or 2 weeks.
whilst having ZAVEDOS
treatment, ask your doctor or
pharmacist. Things to be careful of
They have more information on Special care should be taken if
medicines to be careful with or While being treated it is necessary that you drive or
avoid while taking ZAVEDOS. operate machinery while
with ZAVEDOS undergoing treatment with
ZAVEDOS, especially if you
are in a weakened condition.
Things you must do
Keep all appointments with Take the following precautions
your doctor so that your to reduce your risk of infection
progress can be checked. or bleeding:
ZAVEDOS® INJECTION 2 of 4
• Avoid people who have • red coloured urine for • shortness of breath, swelling
infections. Check with your 1 - 2 days after treatment in the feet or legs due to fluid
doctor immediately if you (this is normal and is no build-up
think you may be getting an cause for alarm)
• swelling and redness along a
infection, or if you get a
• nausea, vomiting, diarrhoea, vein which is extremely
fever, chills, cough, hoarse
loss of appetite tender when touched, clotting
throat, lower back or side
in a vein
pain or find it painful or • stomach pain and discomfort
difficult to urinate • vomiting blood or bleeding
• mouth ulcers, redness and
from the back passage, black
• Be careful when using a irritation of the throat and
sticky bowel motions (stools)
toothbrush, toothpick or mouth with difficulty on
or bloody diarrhoea.
dental floss. Your doctor, swallowing and eating
dentist, nurse or pharmacist The above list includes very
may recommend other ways • skin changes such as darker serious side effects that may
to clean your teeth and gums. areas of the skin and nails require urgent medical attention.
Check with your doctor • loss of hair
before having any dental Tell your doctor or pharmacist
work • hot flushes.
if you notice anything that is
• Be careful not to cut yourself The above list includes the milder making you feel unwell.
when you are using sharp side effects of your medicine.
objects such as a razor or nail Other side effects not listed above
cutters If any of the following happen, may also occur in some people.
tell your doctor immediately:
• Avoid contact sports or other Some of these side effects (for
situations where you may example, an increase in liver
• allergic reaction (swelling of enzyme levels, high blood levels
bruise or get injured. the face, lips and tongue or of uric acid) can only be found
other parts of the body, when your doctor does tests from
shortness of breath, wheezing time to time to check your
or trouble breathing) progress.
Side effects • skin rash, itching, redness of
the skin, hives
Tell your doctor as soon as
possible if you do not feel well • signs of infection such as
during or after treatment with fever, chills, cough, hoarse After treatment with
ZAVEDOS. throat or mouth ulcers ZAVEDOS
• bleeding or bruising more
All medicines can have side easily than normal
effects. This medicine may have Storage
unwanted side effects in a few • signs of anaemia such as
headaches, shortness of The undiluted ZAVEDOS
people. Sometimes they are powder for injection is normally
serious, most of the time they are breath when exercising,
dizziness, looking pale stored in a hospital, below 25ºC.
not. You may need medical
attention if you get some of the • shock due to a dangerous
side effects. Most of the side drop in blood pressure,
effects listed below are reversible. Disposal
which, may lead to collapse
and coma – signs include Any remaining injection will be
Do not be alarmed by the rapid, shallow breathing, disposed by the nurse or doctor at
following list of side effects. cold, clammy skin, a rapid, the hospital.
You may not experience any of weak pulse, dizziness,
them. weakness and fainting
ZAVEDOS® INJECTION 3 of 4
Product description
Ingredients
The active ingredient in
ZAVEDOS is idarubicin
hydrochloride.
Supplier
Pfizer New Zealand Ltd
PO Box 3998
Auckland, New Zealand
ZAVEDOS® INJECTION 4 of 4