Etiology of Secondary Glomerular Disease

Secondary glomerular disease : Glomeruli injured by diverse mechanisms and in the

course of a number systemic diseases.

Glomerulopathies Secondary to Systemic Diseases :

1. Lupus Nephritis (Systemic Lupus Erythematosus)
 Lupus causes inflammation in the kidneys
2. Diabetic Nephropathy
 With diabetes, the small blood vessels in the body are injured. When the blood
vessels in the kidneys are injured, it can’t clean blood properly.
 High level of blood sugar  High blood volume  Kidney overworked
 Diabetes may cause damage to nerves  Difficulty in emptying bladder  Full
bladder causing pressure  back up & injure kidney
3. Amyloidosis
 Most renal amyloidosis is either the result of primary fibrillar deposits of
immunoglobulin light chains [amyloid L (AL)], or secondary to fibrillar
deposits of serum amyloid A (AA) protein fragments
4. Glomerular Nephropathy Secondary to Multiple Myeloma
5. Goodpasture syndrome
 Goodpasture syndrome describe the clinical entity of diffuse pulmonary
hemorrhage and acute or rapidly progressive glomerulonephritis.
 Anti-GBM disease
6. Microscopic polyangiitis
 Vasculitis of small vessels, which can damage organ systems
7. Wegener granulomatosis
 A rare multisystem autoimmune disease of unknown etiology. Its hallmark
features include necrotizing granulomatous inflammation and pauci-immune
vasculitis in small- and medium-sized blood vessels
8. Henoch-Schonlein Purpura
 Henoch-Schönlein purpura (HSP) is an acute immunoglobulin A (IgA)-
mediated disorder characterized by a generalized vasculitis involving the small
vessels of the skin, the gastrointestinal (GI) tract, the kidneys, the joints, and,
rarely, the lungs and the central nervous system (CNS)
9. Bacterial Endocarditis – related GN
10.Thrombotic Microangiopathy