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DM tipe 2

dr. Damar Sajiwo, MARS

Diabetes Type 2

Insulin Resistance

Hyperglycemia

Blood Blood Blood sugar exceeds Glucose cannot Gluconeogenesis


Osmolality viscosity renal threshold enter cell activation

Fluid shifting Blood Favors Glycosuria Cellular Lipolysis CHON breakdown


from Flow bacterial Starvation
intracellular growth
to
extracellular Accumulation Muscle Wasting and poor
Osmotic Sensation of by product wound healing
Tissue Infection Diuresis of hunger
Intracellular Perfusion
DHN

 Urine Polyphagia Fatty Ketones Toxic to Brain tissue


Output Acids
Thirst Wound
Sensation Healing
Acetone
Polyuria Atherosclerosis Metabolic Breath
acidosis
Polydipsia
Ketonuria
Gangrene Micropathy
Formation Macropathy

Diabetic
Ketoacidosis
Amputation CVA, MI, PVD Neuropathy Retinopathy Nephropathy

Loss of Sensation Loss of vision ESRD


Tingling/numbness Blindness
Weakness

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