Medicatia aparatului respirator

Clasificare-antitusive, expectorante,antiasmatice.

Antitusive:
Antitusive centrale opoide:

DCI Fdin Ftox Fcin Fter

Codein fosfat: Constipatie si Biotransformare
Codeina 15mgCPR greata la doze hepatica,difuzeaza
Tusocalmin7.5mgCPR mari,convulsii la prin placenta si in
Farmacod 15mgCPR copii; laptele
Tusomag Sol.uz intern matern,putand
1mg/l produce deprimare
si dependenta la
nou nascut;
MORFINA Ca antitesi in mod
Stupefiant! exceptional:in tuse
f intensa,refractara
la alte antitusive si
insotita de durere
intensa(cancer
pulmonar,fracturi
coaste,infarct
pulmonar).
Dextrometorfan: Insuficienta
Tusin-10mg CPR respiratorie si
Tusin forte-20mgCPR hepatica la copii
Humex-10mgCPS sub 2 ani!
Humex sirop-
10,20mg/ml
Robitussin
antitussicum-
sirop7.5mg/5ml.

Antitusive centrale neopoide

DCI Fter Ftox Fcin Antentionari!

Clofedanol Tuse Absorbtie rapida si
neproductiva,iritanta. aproape totala,eliminare
urinara;
Clobutinol: Tuse Reactii In suficienta
Tabcin,sirop neproductiva,iritanta alergice:prurit,urticarie,som renala si
0.4% ; nolenta,insuficienta hepatica se
Tussamed,si respiratorie,tulburari ajusteaza
rop0.4.4% neuropsihice(sarcina dozele!
primele 3 luni);Prudenta la
soferi!

Butamirat: Antiusiv cu eficacitate Greata,diaree,eritem Absorbtie

Sinecod pronuntata,bronhodila cutanat; rapida,biotransformare
sirop tator.In tuse hepatica
1.5mg/ml; acuta,convulsiva,profi
Tusosedal,s laxia tusei si post
ol.orala0.15 operator.
mg/ml
Pentoxiveri Atitusiv si
na bronhodilatator,in tuse
neproductiva iritativa.
Oxeladina: Tuse neproductiva Prudenta : insuficienta Precautii:moni
Paxeladine iritativa, tuse respiratorie,afectiuni torizarea
,cps.cu spasmodica si cardiovasulare. functiei
eliberare convulsiva respiratorii si a
prelungita40 activitatii
mg;sirop0.2 cardiovascular
%; e(la
admin.intensiv
a)!

EXPECTORANTE
Produc fluidificarea sputei,prin marirea secretie glandelor bronsice,modificarea proprietatilor fizico-chimice
ale secretiei vascoase.

Clasificare:secretostimulante si bronhosecretolitice.

Secretostimulante
DCI Fcin Ftox Fter Fdin
Sarurile de Biotransformare:amoni La doze mari:iritatie Bronsite acute si
amoniu:Clorura ul in uree;acetatul intra gastrica pana la voma si subacute.
,acetat in circuitul metabolic epigastii;stimulare SNC
pana la convulsii:
Benzoat de Iritant Traheo-bronsita
sodiu gastric,epigastralgii,coli acuta;
ci abdominale;
Ioduri (de Na si Distributie selectiva in Potential Bronsita Efecte de
K) tiroida; alergizant,fenomene de cronica,asmatifor hipertiroidie
iodism; ma;
Guaifenesina Iritatie gastrica. Bronsite,traheite, Expectorant,
Adult Precautii:soferi si copii laringite acute si sedative si
meltus,sirop2% sub 5 ani! cronice; miorelaxant.
Robitussin
expectorant,sol
orala
100mg/5mg;
Trecid,sirop si
CPR.

Bronhosecretolitice

DCI Fter Ftox Fdi Atentionari!

n
Acetilcisteina Afectiuni bronho- Bronhospasm,asfixie prin Asocieri interzise cu
ACC,pul,cps200m pulmonare acute si umplerea bronhiilor cu tetraciclina si
g; cornice cu hipersecretie secretia fluidificata. eritromicina!
Fluimicil CPR ef obstructiva,BPCO.
Mucovim CPS
100,200mg
Carbocisteina Mucolitic Reactii de intolerant
Carbocisteina mucoreglatorindicat in digestive:greata,gastralgii,vo
sol.orala 5%; afectiuni ma.
Humex bronhopulmonare acute.
expectorant,sirop
2,5%;
Rhinathiol
cps,sirop;
Erdomed cps
150mg.

Bromhexim Mucolitic Iritatie gastric,bronhospasm. Atentie la

Bromhexim mucoreglator,ameliorea antiasmatici!
CPR,Sol.orala,siro za clearance-ul muco-
p; ciliar;
Bisolvon Cpr
8mg,sirop4mg/5ml
.
Amboxol Mucolitic mucoreglator Rar:epigastralgii,reactii Precautii:administra
Ambroxol sol alergice,diaree. re dupa masa cu
orala,cpr si sirop; CI:sarcina(primele 3 luni). multe lichide!
Mucosolvan Prudenta:Ulcer
cpr,sirop. gastroduodenal.

ANTIASMATICE

Antiasmaticele sunt medicamente care reduc intensitatea si frecventa crizelor de astm bronsic.

Clasificare:bronhodilatatoare; inhibitoare ale degranularii mastocitelor si antiinflamatoare.

Bronhodilatatoare

Fter: In profilaxia imediata si terapia crizelor moderate si usoare de astm bronsic;In tratamentul de
fond(profilaxia de lunga durata)al astmului persisitent moderat si sever.

Exemple:

DCI Bronhodilatatoare adrenomimetice

Adrenalina
Bambuterol:Bambec 10mgCPR;
Clenbuterol:Spiropent 0.02mgCPR;
Efedrina clorhidrat:Efedrina 50mgCpr, sol inj.10mg/ml;
Fenoterol:Berotec,arerosol sol.inhal.100mcg/doza.
Partusisten cpr5mg,sol.inj0.05mg/ml.
Formeterol:Oxis Tubuhaler,pulb.inhal.4.5mcg/doza.
Orciprenalina:Alupent, aerosol,750mcg/doza;pulb.ihal9mcg/doza.
Asmopent, aerosol 750mcg/doza;
Salbutamol:Salmol Easy Breathe, aerosol sol.inhal.100mcg/doza.
Salamol Inhaler: aerosol susp.inhal.100mcg/doza;
Salbutamol: aerosol 100mcg/doza, sirop 2mg/5ml, cpr 4mg.
Ventolin, aerosol100mcg/doza, cpr.2mg, cpr.4mg,sirop 2mg/5ml,sol.inhal.5mg/ml.
Salmeterol:Salmeter, aerosol 25mcg/doza;
Serevent,aerosol 25mcg/doza;
Terbutalina:Aironyl sirop 1.5mg/5ml;
Bricanyl,cpr.2.5mg, cpr5mg, sol.inhal.2.5ml/2ml, sol.inj.0.5mg/ml;
Bricanyl Turbuhaler, pulb.inhal.0.5mg/doza.

DCI Bronhodilatatoare Parasimpatolitice

Ipratropium:Artrovent,sol. Inhal.0.26mg/ml, aerosol 0.03%;

Ipravent20-Inhaler, aerosol 20mcg/doza.
Tiotropium:Spiriva, cps cu pul.inhal.18mcg.

DCI Bronhodilatatoare Musculotrope

Aminofilina- Aminophyllium Retard, cpr.ret.350mg;

Euphyllin Quick 200, cpr eff.200mg;
Miofilin, caps.200mg, sol.inj.24mg/2ml;
Miozone:cpr.100mg.
Teofilina:Teodard, cps.ret.200mg, 350mg;
Theo-SR, cps elib.prel.100mg, 200mg, 300mg;
Uni-Dur,cpr elib.prel 400mg,600mg.

DCI Bronhodilatatoare Antileucotriene

Montelukast:Singulair,cpr film.10mg; cpr mast.4mg, 5mg.

DCI Inhibitoare ale degranularii mastocitelor

Acid cromoglicic: Taleum, aerosol 1mg/doza;

Ketotifen: Frenasma,sirop 1mg/5ml;
H-Ketotifen, cpr.1mg;
Hetarfen,cpr.1mg;
Keto-gal, sol.orala 1mg/5ml;
Ketof,cpr.1m;
Ketotifen, cpr 1mg, sirop 1mg/5ml;
Zaditen, cpr.1mg, sol oft.0.025%
Nedocromil:Tilade, aerosol susp.2mg/doza;
Beclometazon:Aldecin Inhaler, aerosol 50mcg/doza;
Beclazone:aerosol.susp.inhal.100mcg7doza, 250mcg/doza;
Beclocort, aerosol 50mcg/doza, 25mcg/doza.
Becloforte, aerosol 250mcg/doza;
Beclomet Easyhaler, pulb.inhal.200mcg/doza, 50mcg/doza.
Becotide 50 Inhaler, aerosol 50mcg/doza;
Ecobec, aerosol sol.inhal.100mcg/doza, 200mcg/doza.
Budesonid:Budenofalk, cps. Gastrorez.3mg;
Entocort,cps.3mg, 2mg Clisma, cpr.+solv.2mg;
Pulmicort Inhaler, pulb.inhal.100mcg/doza, 200,400mcg/doza;aerosol nazal 0.125mg/ml;
Rhinocort Acqua, spray nazal 50mcg/doza;
Tafen nazal, susp nazala 50mcg/doza.
Flunisolid:Bronilide, aerosol 255mcg/doza;
Fluticason:Flixotide, aerosol.sol.inhal.25,50,125,250 mcg/doza.
Triamcinolon:Azmacort Inhaler, sol.inhal 200mcg/doza.

DCI Antiinflamatoare nesteriodiene

Fensprid: Eurespal, cpr.film.80mg, sirop 0.2%.

Aniinflamatoare corticoizi: beclometazon dipropionat, budesonidum, flunisolidum, fluticason, mometason,
triamcinolon, hidrocortizon hemisuccinat, prednison, prednisolon, metilprednilon.

DCI Poractant alfa

Curosurf, sups.intratraheala 80mg/ml;
Survanta, susp.inhal.
Tratamentul naturist: ceai de Podbal, Cimbru, Ciubotica cucului.
Important:Asmul bronsic se amelioreaza nu se vindeca!