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Pathophysiology - CKD Bana
Pathophysiology - CKD Bana
Adaptive Hyperfiltration
Mesangial expansion Kidney size is normal in
and Hypertrophy
UTZ because mesangial
expansion
GBM thickening compensation.
Afferent vasodilation Efferent vasoconstriction
Glomerulosclerosis
Angiotensin II -
Vasoconstriction
Increased RAAS activation Hypertension
hyperglomerular (HPN – 3 years)
permeability
Na+ and
Oliguria
water
Increased filtration imbalances
Proteinuria of protein and
Activation of
macromolecules cytokines, vasoactive
substances and pro-
PCT take up protein
inflammatory cells
and initiate LEGEND:
inflammation
Clinical
Nephrotic inflammatory manifestations
and remodeling present in patient
Hyperuricemia
END-STAGE
RENAL DISEASE