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Biological Molecules: Proteins
Biological Molecules: Proteins
Proteins - 1
• All proteins are formed from
Biological Molecules: only 20 amino acids.
Proteins
• Small proteins contain less
than 10 aa’s (e.g. insulin).
• Large proteins contain
hundreds of aa’s (e.g.
hemoglobin)
Fig. 5.15b
Fig. 5.15c
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Protein Functions
Structure Storage
Regulation Membrane
Various Amino Acids Contraction Toxins
Transport Enzymes
Protection
Sucrase Epinephrine Venom
Myosin Antibodies Silk
Hemoglobin Antigens Albumin
• Proteins are instrumental in about everything that • Amino acids are joined together when a
an organism does. dehydration reaction removes a hydroxyl group
• Humans have tens of thousands of different proteins, from the carboxyl end of one amino acid and a
each with their own structure and function. hydrogen from the amino group of another.
• Proteins are the most structurally complex • The resulting covalent bond is called a peptide
molecules known. bond.
• Each type of protein has a complex three-
dimensional shape or conformation.
• All protein polymers are constructed from the same
set of 20 monomers, called amino acids.
• Polymers of proteins are called polypeptides.
• A protein consists of one or more polypeptides
folded and coiled into a specific conformation.
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Secondary (2o)
H-bonds cause ...or pleated sheet.
folding into a helix...
Alpha Helix
Beta Pleated Sheet
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• Tertiary structure is determined by a variety of • While these three interactions are relatively weak,
interactions among R groups and between R groups disulfide bridges, strong covalent bonds that form
and the polypeptide backbone. between the sulfhydryl groups (SH) of cysteine
• These interactions
monomers, stabilize the structure.
include:
• hydrogen bonds
among polar and/or
charged areas
• ionic bonds between
charged R groups
• hydrophobic
interactions
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Questions?