Recently got a Wacom One and the cable position on the left side of the tablet has

been a bit irritating, so I found this guide and it worked.

Basically you make a backup of the default preferences file (.wacomprefs) wit the
Preference File Utility, make a copy, edit the copy in a text editor like Notepad++
and such, find this line:
<Orientation type="integer">1</Orientation>

Change the number as needed (I think these are the values, I just named them for an
easier understanding of what the numbers mean, you can experiment a bit):
0 - Portrait Up
1 - Landscape Right Handed
2 - Portrait Down
3 - Landscape Left Handed

Save the edited .wacomprefs file with a new name, reload it with the Preference
File Utility and that's it. I had a bit of a weird workspace area where only the
bottom part went past the Wacom One's dot grid, but you can fix that by defining a
custom workspace area with the Wacom Tablet Properties Mapping options.

Hope this helps!