CITYSTEM

Raw material approved

TM by Ecocert Greenlife,
conform to the COSMOS
and ECOCERT Natural
and Organic Cosmetics
Standards

Marrubium vulgare
Marrubium vulgare, also known as White Horehound or Marrubio, is an edible herbaceous plant of the
Lamiaceae family. It spontaneously grows in temperate areas of Europe, America and Asia. Horehound
medicinal properties were esteemed by the Romans and the Arabs. It is often used in the popular medicine as
a remedy for respiratory conditions and to improve the digestive function. The plant also has anti-inflammatory
properties and is used externally for skin problems.
Thanks to HTN™ technology, CITYSTEM™ is characterised by a very high defined
and reproducible concentration of phenylpropanoids:
Forsythoside B

Forsythoside B

Function:
Picking Pollution Defence from Nature Counteracts pollution attacks.
Properties:
Advanced technology to Makes the skin feel soft and smooth, refines
‘city-zen’ and refreshed skin skin grain. Helps make blackheads less
visible, leaving the skin radiant and purified.
Characteristics:
Protects

Repairs Removes

Strengthens
Protects the skin cells from the penetration
of pollutants and genetic ravage.
Removes and neutralises the toxic oxidant
species that damage proteins and lipid
structures.
Strengthens the skin barrier, stimulates the
skin's natural antioxidants.
Repairs the cell metabolism by replenishing
the energy level and reducing the inflammation.
Point of interest:
Titrated at 350 ppm of forsythoside B.
Applications:
Skincare including emulsions, serums, gels,
lotions.
Formulation:
Water soluble. 3≤pH≤6. Incorporate during
the cooling phase (<50°C).
Sustainable Technology INCI Name:
for Natural Efficacy Glycerin – Marrubium Vulgare Extract
Recommended use level: 2%
As a precious source of biologically active substances, plants have been widely cultivated both in open fields
and greenhouses with large amounts of natural resources and solvents for their extraction and purification. Patent: pending
However, water is a source of life, and land is the habitat of man and animals, providing purifying green spaces
and fertile soil for food cultivation. With growing global concern about the scarcity of these natural resources,
it is fundamental to rationalise their use in a way that ensures their continued availability to sustain life for the
future.
HTN™ is an advanced method that allows access to a wide range of plant extracts, even from rare and
endangered species. When compared to traditional agriculture, HTN™ technology shows the highest reduction
in terms of water consumption and negligible soil occupation with the total absence of pesticides
and other contaminants, in order to decrease the toxicity risk to humans and to preserve the natural
balance of the ecosystem.
Copyright© 2016 Sederma. All rights reserved.
 CLAIM SUBSTANTIATION 03-2016

On normal human keratinocyte cultures

PENETRATION PROTEIN AND LIPID OXIDATION
CITYSTEM™ eq. 2% followed by a PM CITYSTEM™ eq. 1.6% followed by a PM solution.
solution. Particulate matter cellular Carbonylation.......-26%, p<0.01 Lipoperoxidation ........-38%, p<0.01
intake ................................ -76%, p<0.01 Control CITYSTEM™ SKIN BARRIER REINFORCEMENT
Ah RECEPTOR CITYSTEM™ eq. 1.6% followed by a PM solution Skin equivalents produced by Sederma have received CITYSTEM™ eq. 2%
Ratio nuclear AhR/ cytoplasmic AhR......................-82% inhibition and PM the day after. Evaluations were performed two days after.
CYP1A1 mRNA ............................................................-47%, p<0.01
DNA PROTECTION CITYSTEM™ eq. 2% -29.2% +18.6%
followed by a B[a]P solution. Evaluation p<0.01 p<0.01
by comet assay technique. Control Control + PM CITYSTEM™+ PM
DNA damage ..................... -21%, p<0.01 Control CITYSTEM™
ENERGY REPLENISHMENT CITYSTEM™ protects the cells from the penetration of
ATP production CITYSTEM™ eq. 1.6% + B[a]P.................+66%, p<0.05 pollutants, genetic ravage and generation of toxins. It repairs
B[a]P...................................................-33%, p<0.01 the cell metabolism and the barrier function.

Twice-daily application of a cream containing 2% CITYSTEM™ for 4 weeks.

COMEDONES AND BLACKHEADS 30 Thai/Chinese female volunteers mean age 45 (36-50) against placebo.
40 male and female volunteers mean T0 T28 days Test performed in Bangkok by DERMSCAN. Evaluation with VISIA® and
age 44 (21-67). Test performed in Paris. Silflo™ prints + fringe projection technique.
Photograph analysis and extractions with SKIN ROUGHNESS / SOFTENING EFFECT
a patch. Roughness (Ra).................... -9.1%, p<0.05/placebo up to -50% 67%
Blackheads Mean depth (Rz) .................. -7.5%, p<0.05/placebo up to -43% 63%
Number .......................................... -8.8%, p<0.05 up to -50% 68% Max depth (Rt) ..................... -7.4%, p<0.05/placebo up to -47% 63%
Surface .......................................... -8.8%, p<0.01 up to -67% 73%
T0 T28 days
Comedones
Color .............................................. -9.5%, p<0.01 up to -52% 68%
Size ................................................. -15%, p<0.01 up to -52% 78%
Number ........................................ -45.7%, p<0.01 up to -93% 85%
USE TEST with a detoxifying facial sheet mask
100 female volunteers (18-60) tested the benefits of CITYSTEM™ 2% in
a facial sheet mask applied once for 10-15 minutes. Test performed by
Eurofins. They answered a questionnaire just after removal, after an hour
and the next morning.
Sensational benefits
Pleasure to use ..........................................................................83%
Sensation of well-being .............................................................82%
Sensation of freshness ..............................................................96% SKIN GRAIN AND TEXTURE VISIA®
Skin feels cleaner ......................................................................85% Pollution impairs skin grain: heterogeneity ...... +6%, p<0.05 up to +53%
Skin feels comfortable...............................................................76% .....................................................60% volunteers had an aggravation
Skin is soothed ..........................................................................75% CITYSTEM™ Skin grain homogeneity .. +7.3%/placebo, p<0.05 up to 34%
Skin is smoother/softer .............................................................79% T0 T28 days
Visual benefits
Skin is purified/cleaner .............................................................78%
Skin looks less tired ..................................................................74%
Skin complexion is revived ........................................................74%
Provides a healthy glow (1 hour) ...............................................81%
Skin looks less polluted .............................................................72%
Skin is durably moisturised (1 hour)..........................................80%
Finally, an active ingredient delivering noticeable in vivo anti-pollution benefits: CITYSTEM™ prevents further deterioration of skin quality.
In use test conditions, 84% of volunteers felt their skin fresher the next morning.

Based on consumer perception of pollution and anti-pollution products, CITYSTEM™ is especially designed to fight against visible and
invisible pollution damage to the skin. In only four weeks, the skin grain is refined, the complexion looks radiant and purified ; the skin
feels soft and smooth.

v. 160408 Sederma Non-warranty: The information in this publication is believed to be accurate and is given in good faith, but no representation or warranty as to its completeness or accuracy
is made. Suggestions for uses or applications are only opinions. Users are responsible for determining the suitability of these products for their own particular purpose. No
29 rue du Chemin Vert representation or warranty, expressed or implied, is made with respect to information or products including, without limitation, warranties of merchantability, fitness for a
78612 Le Perray-en-Yvelines cedex France particular purpose, non-infringement of any third party patent or other intellectual property rights including, without limit, copyright, trademark and designs. Any trademarks
Tel. : +33 (0)1 34 84 10 10 identified herein, unless otherwise noted, are trademarks of the Croda group of companies. ©2016 Sederma 04/16 PCS PO 008 V1 EN
www.sederma.com Reproduction of all or part of this document without the express prior written consent of Sederma is strictly prohibited.