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    Packaging - Blister

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    Packaging - Blister

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    Packaging - Blister

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    Packaging - Blister

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    Table of Contents (1/2) o1 02 03 Executive Summary sia Development industry Analysis Sliges 35-48 Market Analy: Slee “+ Value Chain Analyse + Global market Outlook ~ Current Marat Size = Demand Trends = Trade Dynamics + Regional Market Outlook (US, EMEA, APAC, Central 2 South America) ~ Current Market Sze ~ Demand Trends = Trade Dynamics Table of Contents (2/2) 04 05 06 Cost and Pricing Analysis, Sider 65-48 + Costand Price Analysis [US, Europe & Asa] cost Structure Anaye3 = Raw Material nce Trend and Forecart Industry Best Practices Sices 65-68 ‘Supplier Analysis Stes 40-65 + key Suppliers — Region-wise + Key Supplies Capability Analysis Geographical Footprint end-use industries ~ Revenue = key Achlavements/Uodatas/ Certifications + Detaled supplier profiling ofthe tan fe label surliers SNOT Analisis for the too fWe global suppliers Research Methodology — The 3C Approach config, 0 i, + category specie leensed subscriptions Inclusion crite * Data relevent to 2017 and 2016 ~ Beroe|P and wlangulated anasis Ry Market, costs, Pricing Industry Analysis Engagement with industry exzerts, Supper surveyeand teleghoneintenvews s eer Vv ~ Industry websites/assocatons specific to the category + Supplier wenstes + Supplier sinveye + Berce knowiedge center which has been buitovers daceds of ecing in the procurementacvizory and merket research Industry Best Practices Engagement with industry ‘exerts, Supplier surveys tre telephoneintenvews NY gots %, () + engagement with industry 20ers * Expert’ Profle: Personnel from various stages ofthe value chan (buyers, supeliers, intermediaries) with extensive excer ence, who are working/have worked in Iarge organizations + Date Collection: statistically si sample concisereg vi surveys an g ont Sunplier Analysis Data gathered tromcase sudiesrelevantto Category irom relevant subscriptions + Supplier websites nd suneys Glossary Expansion aesoarfe Europe, Midsle-East and aica Cyclic Olefin Compalvmer verthe-counter Pol chlro-ti fuore-ethylene Pelyvry chloride Polyetivlene Tereotaate Polyersoviene Food and Drug Administration Chia Restane| ‘Amcor Opaning Festure Radie Frequency Identification ‘compound annual Growth Rate United states United Kingdom Untes Arab Emeater Harmonize System Alucninurs Polyaryidene chionde Research and Davalopmant Mergers end Accuisitions ayysya Me 0 sina Taw vic United States Dele hlore-triuoro-atylene Ultraviolet Low density Polyethylene Foreign Direc Investment European union Pelyethylne ‘word Heath Organization Metre Tor ‘rteh Paune | eure Yeariy Quarter London Metal Exchange (Chet Executive Otfcar Eovrings before intzest, taxes, deprecation. ané Latin Americe| woeconain, Unites Statez Victoria, Australia Stock feaping Lint EN eer 20t serce ine sngit e PT RS ar) Executive Summary (1/4) ster Packaging growin rate: 775 percent (2017-2022), ected ro reach ae of $18 billion by 2022, erven by rugs anc morove pen eenerence me wit navefaser growth of 7.5-8 percent unt 2022 3% 20% 25% 3% [EMEA isthe major demanaresion (2017) a ‘elohal blister market (2017) 2) Seas; see ee onan ene Incustry Best Practices Sete coat scr =e tater seeabliaby casos Rand Sener Fiendiypacaging ~ suppter neovate y nawaiglecang ‘Supply Base Outlock reputed payer sathas ANC prousentey Executive Summary (2/4) + The global marke fo: blister packaging is valued at $13.48 illonin 2017, and tis enpected to grow at 45-5 percent until 2022, reaching SIE llon + Unit-dose racking, short-ycle meiation, and maritored dosage ssternto improve patiert adherence are driving fetos, whichis expecte to increase the mart share of bister packaging fom 18 percent in 2017 torearly 25 percent by 2022 in theveral pharmaceutical caging North america even $5.93 billon demand, growing 7-75 percent o1 $3.90 bitten demerd, rowing t 6.5-7 percent oz _Centate South America $0.674 tition i Gemerd, eoaire 8-85 percent 04 AAC $2.96 tution Gemand, growing at * 75-8 percent soveee EEE o Eo EE Executive Summary (3/4) Demand Market Outlook + Need for patient compliance and regulations are primary drivers for growth of blisters in pharmaceutical packeging ‘+ Innovation in both product and material have attracted demard in developed regions. Increasing healthcare benefits and sale of OTC drugs promote growth for blister packs furtherin emerging regions Perfecseal (Semis) Wingo innovative products that es, aes 5 1 tofen adherence ™— ¥ Lhe Sorencracheretes She Sum oues a curiestonvinton {ne Seema ae comer eee seaupctnacivea ne eee + UFlex Executive Summary (4/4) Major Trends, Innovations and Industrial Development Pee ae oN rene Say ‘Anti-counterfeiting A & La ood 7 fl ] Es E Locking mecha nts, Te nt sale of counterfeit i a nem ee Sc ret slot counter Fy reetaca andra Fy hamilipecccecosers drugangerouoe accent ‘4 i a 3 children but easily used by trace features converters = ‘copolymer (Barex) are making C3 adults: provide printed memory, ‘strong, pone oat Ps + Blisters with production and barcodes and holograms on a dosage instructions printed blister packs that when scanned nad provide assistance for seniors provide product information Se Inanato oro the eathae Esc acure ams an consol oi8,conarta exter faceerabsess ems cnored acaung nt ug warey 28 cured Vitrenrbred Hang fo Sepa aile.Trededindudes —_tvestlag tent topeston Ceundthtfecipetinseecmarct| | fcltynidondond ecagng tfenocherons ence peor ond reduction azets in Malaysia end US pharmaceutical packaging in Asia Market Analysis Supply Chain — Blister Packaging a) Teer cart Eee Thermaforming >Pre-heating an = == = = Lidaing Foil > Heat zeal lncawer + CTFE (Acar ic making a strong resurgence along with Cyclic Olefine Copolymers (COCE|, which can replace the tradtioral VCin making biter packs + thas higher resistance and better moisture protection features compared to PVC, PET and PP + Alu foils is being reploced with oeper and ims aslidding mate-al thet optimize process efficiency Value Chain Analysis — Blister Packaging ‘ley cone (wromtwarai 630 rent Global Market Size — Blister Packaging + sister pacis occupied nearly 15-19 percent of the global sharmaceutcal packaging dung 2017, ands expectedte reach = 22-25 percent during the nex five years cee ‘+ CR packaging with antilock meckanism, pressure sensitive push-through blisters (AOF), BAD chip-ensbled medication comaliaree ne serionferdlyfestures are some of the trencs esso Ameor sunpy ate cctner waste ssamcorand wrth glonal + contact prevailsin European regions Constantia presence have Western Eurcce —growsincacecty —providemateria| better bargaining * Eurefot ‘Sue to foreign bared) power over + risckner players innovations buyers Penton Investment spy se Global Market Outlook (2/2) SS ee + UACI corporation + vetzubich Plastics + Supplybaseis * ‘Therehasbeen ~ Technological ~~ A fragmented fragmented with capacity advancements supply base + Tehn thepresancecf adktiontin China are through provideshigher + Coamofime radium, zmall andincisthreugh global players bargsinngpomer . yeiey andlareepiayers foreign acqurne for vluminaus vestments regonal payers buyers + Taken + supply base's + Northamercan + Technologie + Emergingregins _ soo. feirly regmented —playersinvestin —advancesarein such as Argentine vwsthimany global regionelice terms of and Peru + Honeywell players eyeing Mexico and Grant improving consider Brea aro dveto oroximity —preductvtyand veloping their argentine notte product business with bie markets buyers Global Trade Dynamics Imports and exports increased by 3-2 percent each, respectively, during 2016-2017 globally, owing to economik reglonal progress fom emereing nations that have moved toward selFsuficency 1m 2017, China and Germany are the largest exporter, while the US end Germany ae the largest importer of aluminum fils, Germany isa net conditions, There has been oe oll oll ising cost of labor inthe UShas increased imports by 2-3 percent from 2017 ara is ‘expected tontease in the coming yeas + Exportsin Canada hes beer flat, while ‘Menico registered decline in export level “There hes bean major increase Inimports and exporsin Europe “The markets moving toward sel sufficency with regional big Exports increased by 8 oercert sith Thabard and indonesia nz017 posting 2 growth of 5 cercent nd5 percantfrors 2017 + rmport increased by 10 percent with Thaibrd and indonesia ae? berg the iavgestimporter in pac arate players ike Amcor and Constantia, wna eater to variauscuetornere cro the glcbe and industries WM 220% «ver 70 percent ofthemperts for aluminum fils i tem Mica (52 percent), Bras! (@percent), and Chile (7 percent) + Exports increased by 22 parcert, counties, ike Bazi and Bary showed anincrease F57 and 15 percent, respectively cece 760720 2, suvinm ei Sseas ofa threes excuses fecorag mer) ehing of c0.2 nm ecadng stamping fief heasng 283, are fol wade unas Shstmas fe Global Imports + Germany isthe largetimporter of biterfol sourced regionally within Eurcpe (-80 percent). They erimaryimport from italy, which has decreased 'by 35 percent from 2016 te 2017, ust the overall decline in import of aluminum fol inthelast year ~ Theimgort and exgort levels of aluminum blister folin many regions have been stesiy wih a marginal increase in volume. Counties, tke Tukey, Malaysia, have seen 2 marginal increase inits export levels in 2027 Blister Foil Import by Country (2017) [Major Imports by Country in 2017 ey asia swimerane Tukey vlan coer Tote! Volume (nM) 1,753 15 cose-760720, 12, atumnum fl acts, oa thekness eccueIrg ay acing of 2mm lecuaing samane ‘ol ethezang5212 ana toemaceup ascrrstmas Wee eeortng eter), Global Exports + Abighlyfregrented suoply with low utity end lator costs drives Cina asthe leading exporter of eluminurn ang blister Foils * The countrys exports have risen 16 percent through 2016-2017 in quant. Economic conditions ave brought back value growth from 3 -2 percent 105 percent during 2016-2027 [Blister Fil Eeport by Country (2017) Major Exports by Country in 2017 Total Volume (in MT) bs code. 769729 eA Escad of tsine:eclusng any basing) a! 93 nm [acusng png fale of nendng IDES ane I made up az Covztnae tae cecestng Regional Market Analysis Regional Market Snapshot North America (ian ohn ( ai, timated Morket Demand (2022) SDT eee Ce eels ‘Supply bases fragmented withthe top five suppers baying 30 aercert of market share + Suppliers ae aredeminartly concentrated inthe East Coast egion where nnovzton and technaogy cries the competion cot taba Perec sem) + tase eigen manetwenreary# sercertotne matt lorem + mateo csispenateon are pc moe Oineretar creme cerarer nae Demand Trends and Outlook — North America BEI, 05 cedatons or patient compliance and reduction in spensing errors have created smart shift from plestic EID conainers to buster packs. North american allster Packaging Market (2017-20228) + Market: During 2017-2022, the markets expected to grow at 65-7 percent CAGR, andit is excected to reach $55 billon by 2022. This growth is driver by the need fer patent compliance and urit~dose packaging, which hal in avoicing dispensing erors + There's a market shift from traditional ALA of PVC-All fo PVC-PVDC or PVC-Aclar/Barex combinations, due to improved production efficiency by way of thermoforming + The curant operatingrate ofthe industry tande at 70-75 parcent andthe supaliers are capable of masting any demand zeurgein the future Drivers: Sale cf OTC drugs is curently valued at $44. billion, andi is excectec to grow further, which ncicetes continued growth inthe blister packazing market (Cnial vias require strict patent adherence. which cen be better montores by providing cosagesn blster packs. More than 59 percent ofall the cliical trials cccur ths region, which fuels te grouth of blister packaging Trade Dynamics — North America The US isthe foremost importer of aluminum foils from China, through NAFTA it exports the same te Mexico and Canada +The value of imparts has ineeaced nearly 12 percent from 2016 to 2017, due to growing domestic demand inal the countries of NAFTA ‘North America import share by Country 2017 North America’s import compared to the world trade is riniwal |aepronimately9 percent. This's due to existing foll converters end Fin manufacturers, who have increszed thee caoabilty to cater te the local demand +The Free Trade Agreement benefits Vexico, which imgerts erry from the Usand Canada North Ameria Export Share by Country 2017 + Post the economic recessien, there has been neatly 10 percent increacein the export of bister fil + Mexico's an emerging region within North america, where manufacturers venice set-up production locations to enjoy tax benefits HS Code — 760720, \¢. aluminum ol. backed, ofa thickness (excluding any backing] of <0.2 mm (excluding stamping foils of heading 3212, and foil made up as Christin tee decorating materia) Regional Market Snapshot EMEA + supply base i fragmented wrth much of the local and cbalsuppters, having production lectionsin Wiertem Europe, specealy in Germany snd the UC CTS a PONE Contant + esto © NcknesFentaclast Peer Era PTT) PAT use tc 9 ‘marist share, sang ecanome grout for Poland, “Turkey, Urine, and Rus sie forthe fertex gronth of blister racks at about 8 percent CAGR during 2017-2022 Demand Trends and Outlook — EMEA CEU cro in teattcare stems in aster Erope ad the Mile Zast coupled wth a groning demand for shrt-yle ELOY woseton sthe pout tear pte Europe Blister Packaging Market (2017-2022) ao [I | ae esate) es9(r) 2m) 2m zo 0 + Market: The European markets expected to witness above average growth of 65-7 (CAGR) pe Cent during 2017-2022 and reach $8 lion by 2020, + Mideast ste mest rewarcing market for pharmaceutical and healthcare oroviders.Stagnaticn among established markets necessitates the growth in developing rezors, lke Africa, where tre demand for blister packaging will 0 9-2 5 percent CAGR during 2017~2022 + Converters operate at 70-75 percent of thei aoacrty. A resurgence in economic situation may increase lator costs that may have @ rect impact fon the averll ost ofthe product + Drivers: increasing agac population alongwith the migration of cenore wil acalerate the need for rescy-doze, interactive medication in the Western European region ‘+ Mice Eastern regions, ike the UAE, Turkey, and Egy, offer premium heath ingurance schemes even for nationals nat covered under any other government funded-neatth scheme. Urbanization and increase in the healthare copacty in African regions of South Africa, Nigeri, and Ghana have boosted the demand for pharmaceutical packaging Trade Dynamics — Europe + Europe imports approximately 50 percent of aluminum foll from across the globe. Germany isthe industrial powerhouse in this region, which is 12 major player in aluminum tolls trade * Economic instability within Europe has led to decrease in value of imports by approximately 5 percent from 2016 to 2017, healthcare ‘expansion in Poland and Russia may aid stablty in trade for bister oll, [Europe Import Share by Country 2017 + Growth in healthcare system and economc development of Poland Nelo sscermany rane teelt among he tap five imaorters of blter fie su + Although tere may not be any acverse impact, itis eit fom the €U rota voune cn) ara vill ave a resutant increase in prices of raw materials as thisregion was wee siiererencs ‘themajor exporter of resins ta Europe Europe Export Share by Country 2017 + Germany isthe secanc largest export market and one ofthe most comix acemany ‘economies in the word, t's the hovse tothe largest aluminum fol Sucn ‘ectuders, suchas Ameer, Constantia, and flackner Pentaplast ret vaene Goo “ + olan, Tey, ana Russa are the evereng regions ho ae adene neon a capacity compared te western Europe, where supples are ockerg to seetodenk: ‘eecandin erergingregions somes code 76070, srnmum foi neces ots Heine excusresny acting) of 23 nm evcucne taming fe otneting 1242 and fod mace uae Shosmastie Gecratrg aera) Regional Market Snapshot APAC | =) = ‘high fragmented supply base wth concentration in (lait en) India, China, and Japan ~ adherence toqualty and regulations drives the competition inthis market =) pees Perro coumafine + flee [Usa Cergeration * viteubiah Plates Telia Pe TT 7.5-8 percent CAGR + Growthin econamy,imoroved standard cf ving and healthcare development ae diving factors in ‘emerging countries, such as China ane india O Demand Trends and Outlook — APAC ‘The raion has quickly adapted tothe growing need for regulatory compliance and has facilites that are on par with the international standards. Suppliers in these regions provide quality pharmaceutical products and show willingness to cater to diverse requirements. AAC Blister Packaging Market (2017-2022") cance ravcone 27 sexe) essen) 2e0fr) (1) sen(") + APACis the largest consumer for bister pach, the regions expected to reach $4.34 lion by 2022, growing at a CAGRfE-S percent. Japan contributes to “AO percent ef the APAC pharmaceutical naceagingindusty’s demane, and tic the arget inthis region; t stands second next ‘to the US, in terms of glotal demand. The RED in Japan is incernparable, and the countrys well equigped wth marketing capabiltes to send its, products to global crtdors + Ching, which ez name to nesry3/Sth ofthe worl’: population, ite factest growing agin, regetaring “IO percent CAGR. Ite gradually movng ‘toward high quality ard valuable medicines, which woulé need transparency and barier properties. Measures are being taken to curb ant counterfarnng af ruas + ltr ance se the primary packaging option in ina olowed by vals ampoules, and elatic bots. CR features and senior friendly sachoging ‘cotons drive the reed fr this packaging toe in ths country + Being low-cost soure tr labor and ublty, the converters at ths region operate st 20-85 percent Trade Dynamics — APAC ‘+ Capacity aditions in Southeast Asian regions with a growth of regional big players is increasing at high rate + China stands as the mest prominent exporter of blister foils globally, owing to government subsidies fr low-cost utility and labor Asia Import Share by Country 2017, + inola imports nearly 60 percent of biter flsfram china, primary hus to growng vestments in he incian pharmaceutical packaging > inoustry ‘Global payers, such ae Eecentra and Conctantis,have invested inthe sepniopines Incian market baced on the growing pctental for medical packaging aon spplcstons ees + Thailand and Philipsines in the Southeast Asian region, along with UAE, sesso are emerging region, who have grown steadly intheir imports ‘Asia Export Share by County 2017 ‘+ Allegations tonard quality standards reduced axports from 2008 to 2010, Rectfiation of tese nas ineeased biter fol produttion tremendous by 53 percent during 2011-2015 om vane eT nays {Emerging ass manufacturing hotspot for ahasmaceutcal activities, the "region posted 2 nearly 10 times increase in volume between 2011 and 2015 HS Code - 760720, 2, aluminum fol backed, of a thickness (excluding any backing) of <0.2 mm (excluding stamping foils of heading 2222, and fil ‘made ups Chrstrastree decorating materi) Regional Market Snapshot Central & South America eT Cena) eta Maturity of Suppliers Market Driver: + The marker star fragmented with most ofthe + The pharmaceutical packaging is expected tosrom regional and global supplier having production SLED percent Ca snng 2017-2022 \ceatonin Sealand Argentina + Agacrense in poverty ate ang resutant economic + Chleand Peru are developrgregons tt provée euth over tne pact fen ears fem regione, 22e% ‘uaity products, which attract "D2 SeSrasi Argertino, Chie, ond Wiecco, hve attracted foreign investments for pharmaceutical packeene + Theintroduction of innovative termnolagy he Slow-F-Seal technology andthe need fr ant- counterfetng, are catalysts for markat change Demand Trends and Outlook — Central & South America Rapid urbanization and FDlz have promoted growth in healthcare eystem and sale of OTC drugs that foster the need for bilster packs. Central & South America Blister Packaging Market (2017-2022F) seurerestore 7 oie 229161 202061 aie) mate) + Market: The blister packaging markets growing atte rte of 2-25 percent |CAGR) during 2017-2022, due to rapid urbanization and incresced spending on healthcare by the governments + strct regulations have encourages manufacturers to ean taxIncentives operstingout ths rezon + nnovations in reins made from ‘sugnrcane’ by Braskem and Dow have highlighted the region gcbally for ts sustainability ‘Drivers: inerascing population and wise-coread clear bolster the nc for pharmacautical packaging in spastic ster packs + Basi Argentina, and Mexico are the major diving forces that attract investments frem the US, whichis key driver fer eccnemi end industria \eveloomentin these regions Trade Dynamics: Central and South America + Goverment policies have favored import of ister ‘owing to economic unrest in counties, Bike Bal, Chile, and Mexico the recent past, however, import and export of blstershave reduced 25 percent, ~ sting regional demand and ability of converters to provide quality products have attracted investments in regions, lke Brazil and Peru Central and South America Import Share by Country 2017 esr messi : + Drug packesingin Chile has improved drastically, in terms ofhygiene and smart tacrnalagy, enabling tt exper Sictar material to Sra Peru s the fartest growing aconarnies in LATAN (51 percent) with ‘contained ifation the recent rast hac sean investments in pharmaceutical eckaging * ElSalvador’s coastal pronimity to Costa Rca, Honduras, and Dominican Republic nereazes exports ‘The Chilean government offers duy-fre imgort of packaging material, making'ta leading imperter fr bate fells [though the quantity imported from Mexico as reduced, due t slow economic resurgence, post 2013, has incressedvalue lnverements fem pharmaceutealcompanias ane packaging manufacturer Bran may have an meact on imparts nthe coming Central and South america Export share by County 2017 ( cote -780720 esr 0 bac, of tas laxciting ay backing of<0.2 mr acing taring ols otheseng 5213 and fol mad par chnetmas rae Industry Analysis Porter’s Five Forces Analysis — Developed Regions (North America and Western Europe) ———————— Sar SS ee eer etc. compared to bilster converters J ‘companies who have better bargaining a Se Sa () Ay > ee Se Smite teases tee Tencncowrnaserevacuact Sewer se gy a ere cha product hence bargaining power will O) pore ah + Thebarertoneientrantsis high cue tothe» Theincuctryishighlyfragmentedin __*- listers and stick packs are gsining prominence large intel investment in terms ofequipment ature. ttcantains 3 due to patient adherence and sexcected 10, ‘hat ic ured te manufacture blister pacle players, thusleeding toe highlevel of _gredually absorb the market share of plestic + The manufacturing procass ic complex and compatition containers requitesciesn room facies + Constantinnovationsare equiredto + The only threat tocubsttute blisters would be + Manufacturers areaso eppectec to posses cope wth changing consumer demancs diferent flexible packaging procucts such as certifications ane must meet customer and intensifying the competition in the sachets, pouches, stick packs etc. depending ‘state FDA regulations industry Upon their usabilty for medication sewtotroner (>) tew (T) mason (C) en Porter’s Five Forces Analysis — Developing Regions (APAC, Eastern Europe, MEA, and LATAM) La aS Sees ae Saar global playersthatreduce the e better bargaining power to the buyer bargaining power + Pharmaceutical companies are large a OO) Sige cheatin Gece ia occ aesestoe ee a ®4\@ i reduced + Beings fragmented market with tot * ated on macieation and treatment, treat for + Emerging regions suchas Chile, India, ‘China and Poland have special provisions for setting up industries suchas blister retional players investments from bisters is very minimal. OTC products for packaging wich intensifes competion slobal companies has increased household diseases are primarily bister packed + Compettion is either acquired or competiionin thismerket + inerease m nutraceuticals promote the growth marged with global payers + Adaotabrityto innovate and ‘of sachets and stick packs fr oral + Opening upefthe exonamy har compliance towards regulations drive __—povrder/Equid doses. They donot contribute nurtured capital inflow for development competiten gormerngatertion oF any sigifcant test to blister packs in pharmaceutealincusty, thereby large ouyere ‘allowing new entrants in tre market Levetotrower (—) tow > sean oO vigh Industry Drivers and Constraints Feaulations + Regulatory bocies (suchas, the FDA and EU Legation) are taking stringent measures to ensure patlen-comal ance whichis provided by bisteroacis combared 10 other packaging formate ~ Inanefferttoavoid ascensingerors, the FDA has made I mandatory fora hosptals/cines and pharmacies to provide mediestion in in-dose format. Ths sees the rarkat vf from last bottle te Betas intra US, ering te damane Patient Compliance * Improved patient compliance, hid resistance an senior friendly features willbe the rajormarket rivers (ff Patenting and Clinical Tails, + Offpatenting of drugs wil boost the growth of OTC sales in many region, especially in eveloping rations * slster packaging isthe most preferred type of packagng in clincal tals, mainly due to patient compliance and other features, such as expanded label content, high sty and builtin veckand-trece features, Oy Recycabity ~ Segregation of multibie materials ke lu are plastics hinder the proces or efficient recycling blster packs Doseze + Blister packs cater te shortcycle medication and unit dosage formate, longterm medication requiring dosage titration would not be pessile cost + Volatte rices of plastic resins such a5 PE or PP and fuctuations in Alu fal prices affect the cveral cost of blster packs compared to other pharmaceutical packaging eer Le Key Industry Trends — Blister Packaging + Traditional Sarexis being replaced with Actar and COC (eylic-lefincopalymers|, which has high bariar properties and Material resistance to oxygen, light and moisture. They aso possess reduced heat sealing prepertes and better tenilestrenzth Innovation + _armcor, Constanta and Berns have come outwith various alternatives anc ae till working on caring outwith mare {uttsinable snd anvronmantfiandly materale * Inthe Us, the WHO notes thatthe average non-compliance rates 60 percent amang tients with chronicillnass.nnevation byway of calendaring the mecication (through calendar Sister packs) andfurtnar technological advances ave way for Patient interactive features, kee erinde through text messages Compliance + Example: A research team in Singapore has come up ith ase expring biter pack This muit-layer sack disintegrates cexcoring the warning label tots patents once the expiration date has pazzed. The blister package har builtin ensor made cofnang particles, which makes this poss ble roa |) sooncesine ese packaging Incude rack trace feature, senalzation and ant-counterfeting measures. M&As - Blister Packaging Counties ts mth PoP actin Torro guar of ntin nat eonnenaeio phrase ven intUretnoVehmrtnOn Tee ced See Tera ete ene ren ern oar errr y paca oye SS rs Bernie growls eather packaging by acing Stipa abl mantel paca + pecennducesteclty mirror paclagngpeauctonssets iayo andthe Us 0 Sterpack recorded a net sales of $65 millon during 2015 iting ned Packaging Pvt. Ud. Es ‘Acquiring Kamsri during March 2016 provides an entry to the Indian market for Essentra ems @ major merufacturer of premium packaging solutions forthe pharme end healtheare markets = Wet a view to increase sales in APAC, ssentraintends to spend £209 milion in acquisitions Industry Events (1/2) Shen SS Toc he govinda om SER annette mr mmc BS 1 Nppstao poco nce nt png eens oO Constantia Fleibles erpande production capacity in Aust Impact on Industry “The group Invests a Euro double-det milion for its pharmaceutical packaging ~ Constantia Patz, Austla + One doubla-sdee ‘sequering machine for foil arc lainataz and one ltting machine oparatingin anew clace@ eesnroom The ests i wis sii to come on stream ely 2019 Optimizing to produce medium barter blister fis, the new coating line in Suzhou has the best technology + The camera detection system inspects 100 percent af the coating sutace and guaranteas manimum safety ~ Highest GMP standerd, cleanroom class D underscores this center of excellence for pherme blisters ‘Sharp invests 9 milion pounds in Welch packaging business Impact on inductry ‘The project willhelp develop analytical capabilites, adding automated boiling, blistering and serialization + It's proposed to doublets headcount wth adhtional 73 Jobs created with ths investment ~ The investment alzo includes 500,000 pounds fom the Welsh Government Wacdell vests Eos Soo The pharmeceticl contact menfatrr ad pacagerinested in anew RomocoNeockisterln forts rey oly + "the wevonredts nee ann proienas apaety by eto-50 elon See ¢> vases urey te lead home toto NeackO00 ler paging machines Industry Events (2/2) [MSU Palys making progress with its specialty resin designed to rapace the cscontinued Barex * The company has already spent $75 milion ané would be spending anther $15 millon by end of 2018 ‘Anobexis undergoing vaidation in Europe, North Americ, and apa. l'salready dtributed in Europe by Se Ss ‘The company is expending cleanroom copstitiesin Gahvay, elon; Heredia, Cost ica; and Venray, the Netherlands. * The company naz alzecomplated Cae: 200,000Pre-heating | tiene Te == res | Cooled > Forming Film | Lidding Foil > Heat ceal lacquer ‘Al ingots “+ PCTFE (Acar is making a strong resurgence along wth Cyc Olfins Copolymers (COCs), which can replace the wactional Key PVCIn making biter packs insight “thas higher resistance anc better mossture protection features comparesito PVC, PET and PF | Alu foiles being replaced with paper ane fis azlicing mataral that optimize process efficiency Value Chain Analysis — Blister Packaging errs Fal oduet Br 00 Packaging Global Market Size — Blister Packaging Blister packs occupied rewry 18-18 percent ofthe glcbel ehermaceuticl packaging during 2047, andit's expecta to reach 7 Ge EOD © crease en asccrrecranen, resi seer pushover Aor, A hentledmacaton ‘compliance, and senior friendly festures are some ofthe trends associated wth bata packaging Global Blister Packaging Market [2017-2022 F] (RGR: 4.55 percent soe ae, 208 aneer) 2m 2021 sour trae aay ‘Demands rven by growing ole age nanulation in Western Europe, whos the largest consumer forbster pact gicbaly, development in healthcare system promotes the grouth of blister packs in develogng egies ike ACs, LATAM, Mile East and Arica + Miele East ad afnca shows maximum grourth, witha CAGR of 9 percent during 2016-2021, owing te improved heaitncare developments and sale oF OTC druge + Thareie sft from plastic containers ta liter in North Amenea toad batter patient compliance forthe growing ols age aanulaton Global Blister Packaging Demand by Component Key \bity of te reduc along ith barrer properties Se * . . pee Major components used while making blster packs are formingfim, idcing materia, heat sealant adits), and ink for printing * Forming fims account for nearly 80-85 percent, and idding materials occupy 25-20 percent of the averl bleteraactagng went + lms are expected to witness highest grouth at CAGR of 75-8 percent ‘during 2027-2022. Tis c becouse thermoforming lme.are referred over CColéform Fels (7, which are made of Alu cormpetely Ldeing materials include ae, fin, er Alu sheets. Paper and plastic fins ‘re gaining prominence oer alu iding materia due to ease n lnovation perttining te chic-restarce or exsy-open festure + Thaze CFF types of packs arovide et tranggarancy ane slow areduction speeds compared to thermoformed fils, which offers clear visiilty and ‘optimizes production + Secondary containers, which include folding bores, cartons, presrition containers etc, are rowing at 7=7 5 percent cack + packaging accercoree are ncarts, shrink mater, eacurty components tamper evident sels. Packaging inserts are crversfer any packaging format, ‘sil ses patent compliance and provide comalete product information Modern day blister lines con easly pack ,000-1,200 bisters per minute woiT—20s8(@) 2019(0) 200017) 2021(7) ‘+ There isan inerensing trend in the usnge of therwoformed bizters, 2s attracts customer attention by provicingcleor + anf towards thermoformed alstr pace wil reduce the use of Alu, thereby improving process eficiency and cost Global BI ister Packaging Demand by Type (On-the-go mevication, comeriance, ané privacy foster the gronth of wallet packs in developed regions, ite North America ‘and europe Monitored Desage System (MDS) offered by comoartmentancts nid patent adherence cee (lobe Bster Demand by Type (2017-2022F) eon © Compartment packs occupy the mast share, adits expected to reach $13, ae tion by 2022. They offer bulk dosage of 30cr 60, with seniar-ftendly push- ee packaging see + Side paca ore pally esirg prominence owingets CAGR 75-8 a percent during 1017-2022, snce they provide better C3 features tran the ther blister types locking mechanism guc a + although compartment and side packs are voluminous in demerc,wallet 3 packs are oxpected to post hgh growth at asteady CAGR of =8 5 percent uring 2017-2022 ~ ‘These packs offer convenience, in terms of adhevence asthe bbeokletpraduct information remain in the pack This sone aitherby soo i printing on the side ofthe folding carton or by inserting bootltin separate peel sear ee) aeaa(r) sea0(¢)_ ose e)a022 (0) Global Market Outlook (1/2) * supply bases * Recenty, sharp * Innovation's_——* Supplylbase * periecseal ‘ragmemedwith —_hasadded bister—drweninterms—includesregional_-—_«(BEMis) innovation driven packaging of product big players whose. Wancak competition capactyinFlorda formatsthatare powers andNelpacnat — CRanasencr——moderatadby ——* COL Labels eroandecin ‘rendly largepharms = Leften Puerto Bice companies + Aftagmerted + Polandamong + ‘ig playerssuch + Largeconverters + Amtor supely bare ‘other Western se Arncor and with global «constants prevails in Europesn regions Constantia presence have Western Europe growsin capacity providematerial better bargaining _* ‘furotoll ‘Sue toforeign eased poner over «Klockner players Fnnovations buyers ol EMEA investment Fentaplast Global Market Outlook (2/2) * nes Corporation © aa + Suppiyaceic + ‘Therehas been + Technolegcel «== + Afragmentes fengmented with capacity ecvencerents suppiybase—* TP theprerenceof adationsinChing_—arethrough proviseshigher + Cosmofims ‘edium,small andindiatiwoush global ayers Dareainine power. ex andlargeslayers foreign ecuieng forvoiuminous Investments ragonalayers buyers + Toe lex + Suppiybaseis + NorthAmerian + Technolesicel © * Emerpingregons | oe firiytragrentee alayersimvestin. —sevaneerarein. such ae Argentina wth manyglobal —Fegtns ike tens of andrew * Poreyal playerseyeing Mexico and rec improving consicer brat and duetoproxmity —productivtyand developing their argentina rottheproduct business with big waren variate buyers Global Trade Dynamics + imports and exports increased by 5-2 percent each, respectively, during 2016-2017 globally, owing to economic conditions. There has been regional progress irom emerging nations that have moved toward self-sufficiency + 2017, China and Germany are the largest exporter, while the US and Germany are the largest importers of aluminum foils. Germany i a net exporter of aluminum foils imports by 2-3 percent from 2017 ends ‘expected toincrease inthe comine ears + Eaportsin Canede has been fla, while ecco regsterec adecinein export evel © Therehas beerino majorincrease Inimeorts snd exportsin Europe ~ The markets moving toward self saficiency with regional big inz0w7 «we player, ite Amese and Constanta, = ‘who ester to vereuseustomert u 3 across the globe and indusines EE roo eis ser MIMI 122% - yer 70 percent ofthe import for alurrinum fii from Menieo (52 percent), Brazil Spereent) and Chile (7 percent) + Exports increased by 24 parcert, countries, ike Brasil and Paru, showed an increase of57 nd 45 percent, respectively asa pact + Exports neranced 5/8 percent sith Tharane and indonesia posting a growth of 65 percent 30485 percent from 2017 + pnports inerested by 10 percent with Thaler end indonesia being the largest maortrin PAC chess ecusig any basing) 205 mn (ccusng stamping oie thandng 253 otcfolvade unas shemmas tee Global Imports + Germanyisthe largest importer of blister fl zourced regionaly within Europe (~€0 percent). They primarily import from tly, which hae decreased bby 36 percent from 2016 to 2027, due tothe overall decline in import of alursrum folin the est year + Theimport and exort levels f aluminum blstor fol in mary regions have been steady witha marginal increase in volume. Countries, ike Turkey, Malaysia, have seen a marginal increase inits export levels in 20177 Blister Foil import by Country (2037) ‘Major imports by Country in 2037 Total Volume (in 7) 714,753 rssc0de— 700720, 2, suminun fl eee of anes (exc ay Bean ofs0.2 mm Cucirg Sangig fs of heating S212, ane feimace uo BCAAs fecenng tera) Global Exports + Abighly Fragmented supaly with lw utility and labor costs drives Ching asthe leding exporter of aluminum and blister fils * The countrys exportshave risen 16 percent through 2016-2017 in quantity Ecoromic concitions have brought back value growth from 3-2 percent 0 5 percent during 2016-2017 — a ce ss Regional Market Analysis Regional Market Snapshot North America | ae pated [Maturity of Supatiers * Supply base is fragmented withthe top five suppliers having 30 percent of market share * Suppliers are predominantly concentrated inthe East Const Region, where innovatien ard technclegy drives ‘thecompetition * ccLLabele + Perfecsea| (Bemis) © often © GliverTelae Demand by Country (2017) ry thet the larect mare ith any #7 perce af the mart Demand Trends and Outlook — North America BE a, :ossecciatne for patient compliance and reduction in dispensing errs have created a mart cit from pani EEO) crrcinestotiste nce: North american Blster Packaging Market (2017-20227) a x7 182) 2nsin) 220 F) a4) 2226} + Market: During 2017-2022, the market is expected to grow at 65-7 percent CAGR,anditis expected to reach $5.5 bilion by 2022. This growth is deven by the need for patient comeliance and unt doze packaging, which halps in avoicing dispensing errors + There ia market sift from traditional Alu-Alu or PVC-Alu to PVC-VDC cr PVC. Aclar/Earex combinations, due to improved preduction efficiency by way of trermaforming + The current operstingrate ofthe industry stands at 70-75 percent and the supoliers are capable of meeting any demand spurge in the future + Drivers: Sale of OTC drugs iscurrently valued at S43 billion, andi is expected to grow further, which indicates continues grow inthe blster packegngmarcet + Clinica tas require strict patient adherence, which can be better monitorec by providing dosages in blister packs. Wore than $0 percent of athe clinical ils ocur inthis region hich fuels the growth of blister packaging Trade Dynamics — North America ‘+The US i the foremost importer of aluminum flls fom china through NAFTA It exports the same to Mexico and Canada + The value ofmports has increased neatly 42 percent from 2046 to 2087, duc to growing domestic demand in al the counties of NAFTA North Ameria import share by Country 2017 1 + North America's import compared to the world trade is minimal (soprcnimatey 9 percent). Thies due to exzting fll converters and film manufacturers, who have increase the cavabiity to cate tothe oon local demana| reiealeme finn canada + The Free Trade Aersement benefits Mexico, which imports orimasy ‘rom tne Us ane Canscs Smeoe ‘North america Export shave by Country 2017, + Fost the economic recession, there hasbeen nearly 10 percent increase in soe ‘theexpor of biter ols ea lune fin shesrase + Mecco isan emerging regen within Nort America, where manufactures set-up production locations to enjoy tax benefits HS Code - 760720, 2, suminum fal backes, of thickness (eluding any backing of 20.2 mm (encluding staming fol of acing 2212, and fei ‘made ups Cnistmas tee decocating mata) Regional Market Snapshot EMEA Qo | pacts - 6 ( eee eee a) ee Lia ‘Maturity of supers ‘Demand by country (2017) + Supply baseis fragmented with much of the local and 3 lobal cupplirs, having production locations in vo Western Europe, specifically in Germany and the UK Succ nee O 70% amcor Constants + Although Western Europe occupies amgjoiy, in terms of iuofol ‘market share, strong econome growth From Poland, Kockoerpertglat Turkey, Ukreine, and Russe aids fr the fastest gronth of blister packs at about 8 ge/cent CAGR during 2017-2022 Demand Trends and Outlook — EMEA Key Growth in healthcare systems in Easter Europe and the Middle East coupled with 3 growing demand for shor-cyle fkeawoy medication ad the growth for blister packs. ‘Europe Blister Packaging Market (2037-2022F) ae a || . 2037 - ‘zone (e) 20296) 2020 (F) 2023 () 2022 (F) ‘+ Market: The European mariat is expected to itnass above average growth of 65-7 (CAGR) percent during 2017-2022 and each $8 lion by 2020 + Midi Eat is the most reversing marke for pharmaceutical and heelthear provers. Stagnation emong established markets necesiates the zZrourh in develoain regions, tke ance, where the Gemand for bister nackaain will be S95 percent CAGR Our 2017~2022 + Converters operate st 10-75 percent ofthe capacty. A esutgencein economic stustion may increase labor cost that may have a irectimpact onthe overs eat ofthe product + rvers:increasing aged population alone with the mieraton of senors wil accelerate the need for rezcy-dose, nteracve medication inthe Western European region + Middle Eastern regions, ike the UAE, Turkey, end Egypt offer premium healthinsurarce schemes even for nationals not covered under any cther zovemment-funded-health scheme. Urbanization and increase inthe healthcare capacty in Aican regions of South africa, Wegera, and Ghana have bocstac the demanc for pharmaceutics! packaging Trade Dynamics — Europe Europe imports approximately 50 percent of eluminurn fil from across the globe. Germany isthe industriel powerhouse in this region, whic ‘a major player in lurninum tolls rade * Economic instability within Europe hes led to a decrease in value of imports by approsimataly 5 percent from 2015 to 2017, healtheate ‘expansion in Poland and Russia may ai stability in trade for blister foils Europe import Share by Country 2017 ~ Growth n hesitneare system ane economic development of Poland lp asemany rank self among the top five importers of aster fos au. + although there may note any adverse imoact,Eritan’s ent fromthe EU rerevauime yn or face ‘wil hve a resultant increase in rces of rew motertls, = thisregion vas sas chews ‘the major exporter of resins to Europe ‘Europe Export share by Country 2017 + Germany's the second largest export market andone ofthe most complen capacity compared to western Europe, where suppliers are looking to — eoend inemerzing regions cote ~ 75720 2, snrun onic, ot cea excuse ay bac 2 £02 Wm esclng Nanpig os these o32 ae ‘ol mace pasChremes tas Regional Market Snapshot ApaAC rae Tue Ny + Aighy fragmented supply base with concentration in India, Chine, ene oer oh ~ adherence focualty and regulations crves the 2 a competition inthis market eine Ccoxmefims “comes Ure 0 + Growth n economy, improved standardoflvingand URC! Corporation| Ninsubien Beste: healthcare develoomente are driving factors toe ‘emerging countries, suctes China and Indie Demand Trends and Outlook — APAC SOR, Berens goning nesters compan a ait ater ihe DED G Pp craton sane spas nese eins prove gay ptorocetcl prod’ ane wigs te ters oa diverse requirements. -ADAC Blister Packaging Market (2047-2022) oa soit) amie) (8 2022(F) ae + APAC ithe largest consumer for bistor pack, the regions expected to reach $4.24 bilion by 2022, groning ata CAGR of 8-9 percent. Japan contibutes to 49 percent ofthe APAC pharmaceutical packaging Industy’s demand, and itistre largest inthis region, stands second, ext ‘tothe US, in terms of global demane. The RED in Japan is incomparable, and the country is well equipped with marketing cepatiities to sends roductsto global corridors + China, whichis home to nearly 1/5th of the worlds population, the fastest erowing egion, registering 10 percent CAGR.It'seradually moving ‘tonard high quality and valuable mecicinas, which would need transparency and barrier propertes. Measures are being tatento curb ant- counterfeiting of rugs + ster packs are the pnmary packagng option in india, followed by vale, ampoules, and plastic hotles. C3 features nd senlor-frencly nackagng ceptions drive the need fer ths packaging type inthisccurtry zing l-cost sours fo abor and tity, the converters a this region operate at 60-85 percent Trade Dynamics — APAC Capacity additions in Southeast Asian regions with a growth of regional big players is increasing at a high rate China ctande asthe most prominent exparter of blister foils glabally, owing to government ubsdies for low-cost utility and labor ‘Asia import share by Country 2017, India imports nearly 9 percent of blister fils from China, primarily hue ta groning vestments inthe Indian pharmaceutical packaging roa roustry (Gooba players, such as Essentra and Constantia, have invested inthe iorines lncign market based on the growing gotenial for medial packing acins eppictions| ane + Thallandand Philipines in the Southeast Asan region, alone with UAE. esses are emerging regions, who havegroum steadivin their imports motes ‘Asia Export Share by Country 2017 + Allegations toward quality standards reduced exports from 2008 to 2020. Rectfestion of thaze hac increased klcte fol production t-emencovzly by 53 percent during 2011-2015, merging as @ manufacturinzhot spot for sharmaceutcal actives, the sterey "egion posted 2 nearly 10 times increase in volume between 2021 and 2015 ee HS Code -760720, ie, aluminum fol, backed, ofa thickness (excluding any backing) of 0.2 mm (excluding tampi trade up.asChristas tree cecorating reaterial) foils of heaging 2222, and fil Regional Market Snapshot Central & South America e Eyed s 2 —k== - Call Cette re) Peet eeu a (cL) \’ ‘maturity of supers Market Drivers +The market ifr raginanted with most ofthe * The pharmaceutics packaging = expected to grow regional and global uppliershaving preduction at 115-12 percent CAGR during 2017-2022 locators in Brzilara argentina + adacease in poverty rate and resultant economic + Chile and Peru are developing regions that arovide {growth over the past few years from regions, such unity products, which attract FDIS 2s Brac Argentina, Chile, ard Menico, have _tracted foreign investments for prarraceutial Global ‘Amcor psdagne supotiers EC + The introduction of nnovetive technology ke Biow-Fil-Seal tecnrology andthe need for ant- Maze counteretng, ae catalysts for marke: change Foneywel Teenie Demand Trends and Outlook — Central & South America SP capt arzaton nd FAshae promoted rovthinhethae stem and sale of OT rugs that foster th need for (GP ist smc. Central & south America Blister Packaging Market (2017-2022F) cern 2 zaueie) z(t) zen) 2e2(7) 2e22(7 ‘+ Markets The bister packaging narket is growing atthe rate of 8-€.5 percent (CAGR) during 207-2022, due to rapié urbanization and increased sperdingon healthcare by the governments + Strict regulations have encouraged manufacturers to eam taxincentives operating out ofthis region + Innovationsin resins mace from ‘sugarcane by Braskem and Dow have highlighted the region glotaly forts sustainality * rivers incressing nontlation and wide-spread izences bolster the rac for pharmaceutical packaging inspect ster packs * razi, Argentina, nd Mico are the major ervng forces that attract investments from the US, hich is key erive for economic and industri evelopment in these regions Trade Dynamics: Central and South America * Government policies have favored import of blster foils in the ecent past, however, Import and export of bistes have reduced 2.5 percent, ‘ning to economic unrest in countries, like Brazil, Chile, nd Meio * Strong regional demand and ability of converters to provide quality products have attracted investments in gions, lke raziland Peru central an! South America import share by Country 2017 + The chiesn government offers duty-free import of packagne mater rmakingit lescingimoacter for blister fas + though the quantity imparted from Meticohas reduced, cue to slow os) seven economic resurgence, post 2023, has increared value rst + Investments from pharmaceutical companies and packaging uacenine ‘ranufscturer in Basi may have an imgacton iniortsn the coming ones yess ‘Central and South America Export Share by Country 2017 + rug packagingin Cale has improved drastically, in terms cf hygiene and mart technology, enabingit to eicort alzter matersl to Brat moue + Barus the fastest growing economies in LATAM 6.1 percent with a ssisnaser Contained infation the recent pastas een investments in eevee ‘Dharmaceutce packaging ~ I 5alvador’s coastal pron to Costa Rice, Honduras, and Dominican Republic increases exrorts code —7e0v29,e,sluninun fl based fe tcions[scesingay basing of D2 nm (nckdngstongns tec Industry Analysis Porter’s Five Forces Analysis - Developed Regions (North America and Western Europe) + fein an ingot manufacturers ate a + Rego he US en Europe house ome feerin umber fe Dow, BASF Aon efthe bigest sharmaceatea Saeed Y comrganies who hove beter borgining hing ov ate supliers a ener owe interme of volire ove supers power inthe value chain (O) ©® + Cost aualty and time factors increase + The volume and size of blister packaging -puiitching cost which balances buyers: manufacture would help determina the roe bargaining power with the suppliers Seared + con srdounityconrbutonet a Sipps are hgh towards tha ial product heen bargaining power wl O) i Hoobebch + Thebarrertonew entventsis higndue tothe + Theindustryishignlfregmented in __*_‘sters and stick packs ae gan lage initialinvestment in terms of equipment nature. contains large number of ue to patient adherence and isexoectes 19 that is used to manufacture blister packs Hlayels thus|eading oehigh levelot gradually absovb the market share of plastic + The merufecturing process is complex and competition conteiners requires clean room focties + constantinnovationsare requiredto __* Theoniy threat tosubsttute bisters would be + Manufacturers ere aso expected to posses ‘cope with changing consumer demends diferent flesble packeging productssuch es, cettifcations and must meet customer and intensifying the competition inthe sachets, pouches, stick packs ete. depending state FDA reguiations industry ‘upon ther usability for medication uwetetrener (tow () mean (C) vn Porter’s Five Forces Analysis — Developing Regions (APAC, Eastern Europe, MEA, and LATAM) + Theresia oper market a ihly aaa +The nent nto the ster {greed thar ofrepors and backapn sippy bce oul rove 8 lool payers thtredice the N a eee borer power + Pharmacie comparies ee lrze + There ent much product (9) ‘uth nig vores wich wuld lain ee eed ineressnethe ponercfthe siete th pvt nna = ether are + merging regions sch Chie nd, ‘China and Peland have special provisions Being afragmented marietwithotof asad on maieation and treatment, threstfor for settre up industries such as bster investment rom Listers is very minimal. OTC products for packaging whic interstfes competition has increaseo household diseases are arimaly blister packee * Competitions ether accuired or compettan inthis mariat + Increase in nutraceuticals promote the growth ‘mergec itn gobalplavers + Adaptabiity to innovate and cf sachets and stick packs fr oral + Opening up ofthe economy has compliance tonards regulations drive _poutder/iquid doses. They dont contibute urtuted cit inflow Tor develooment compattion, garnering attention of In aharmaceuteslinducty, thereby large buyers allowing now entrants in te market ‘thrant o bleter packe vemiereone (—) tow (TY mraen CO) ven Industry Drivers and Constraints Regulations ‘+ Reguistory besies [such 2s, the FDA and EU Legstaton) are taking stringent measures to ensure patientcempliance whichis povided by bister packs comoared tother packaging formate * naneffort to avoid olspensing errors the FDA has made t mandatory fo all hospitaly/dinics ane pharmacies to provide madication in unit-dose format This sees the market shi from plastichottls to bsters i the US, driving the demand Patient Compliance “improved patient compliance, ehid-vesctance and senir-‘nendiy features will b= the major market ervers (off-Patentng and Clinical Trails + Off patenting of cru wl Loos the grouth of OTC sales in many regions, expecallyin develogingrations. + Bister gactagingis the mast preferred typeof packaging nclncal tras, mainly dus to Dallent compliance and other festures, such as ezanced label content, high vsiblityané ullin trackeand-tracefestures. ecyclabity ~ Segregation of multi reeyelng blister paces Dosage * Bister packs cater to svar ycle medication and unit dossge formats ong term mecicationrequring dosage tration would net be possible cost * Volatile prices of pasticresins such 25 PE or ®P and fluctuations in Alufol ices affect the overall cost of bistar packs compares to other oharmaceutca packaging evils ike Aly and estes hinder the process for efcent Key Industry Trends — Blister Packaging + Tractional srox being replaced with Aclar and COC (yeiolefin copolymers), which has high karrer properties and material resistance o oxygen, light and meisture. They also possess reduced heat sealing propertes and bette tensile strength Innovation - Ancor, Constantia and Bemis have come out with various alternatives and are stil wockirg on coming out with mere gusta able and ervironmantnendly materale went) Pre tia ganar ne npn CPE + nthe Ls, the WHO notes that the average nor-compliance rates 50 percent among patients with chonicilness. Innovation by way of ealendaringthe medication (through calendar blister aac) and further technolegcal advances pave way for Patient Interactve festuras ka = reminder trough feet meeeape= Compliance + Examele:Arecearchteamin Singapore has come up with 3 sett apinng bister pack. This muit-ayer pack disintegrates exposing the warninglabel to tspatients once the expiration date has passed. The blister package has abun sensor mack ‘of nano particles, which makes this possible Impact Oo ‘Advances in theze packaging include, tec & trace feature, cerislsation and ant counterfeiting meacures M&As - Blister Packaging SS = Contensenes wet sry Pa Pckacsitin rs 0 * Gal Fung’s primary busines is aluminum Dist fol, dar lids, and aid fm forthe local pharmaceutical market = The company had a sales cf $28.3 milion during 2015 and emoloys 240 ecole eta So "PEE rae ar ermenfot Ren tren edb Ns hy ye ltherlands, and Costa Rica Semi rotate caging by aging Stipa, abl manatee package 1 decency londond pacagng wesuctonenls nny and thee 0 poner atl of 0 ln cas De Sd ‘Acquiring Kami during March 2016 provides an entry tothe Indian market fr Esertra «+ Kamsn #18 major manufacturer of premium packaging solutions fr the pharma and heathcare markets — With view toincrense sales in APAC, Essentra intends to spend £200 milion acquisitions Industry Events (1/2) eee Impact on industry Toc rg Sean om ES Sn tre ney ray ° Recroslteecetcerr nilixfced ember reeset nee’ Oo *fncrcoaalyuiiesrcendnbe ena SSS aad So ‘The group invests 2 Euro double-gkt milion fo ts pharmaceutical packaging ~Constantla Patz, Austis + One double-sided lncquering machine for fiz end lannates and one sting machine operating ina new class 3 Optimizing to produce medium berser blister fils, the new coating ine in Suzhou has the best technolozy +The camera detection system inspects 100 percent cf the coating surface and guarantees maximum safety — Highest GP stancars)claanroom caze D underscores th cantar cf excellence for pharma blistert ‘Sharp invests 9 millon pounds in Welch packaging business ns ‘The project will hep develop eneltical cepabilties, adding automated botling, blistering end se «+ iepropoted to couble te heaccount vith adeitional 73 oe craatad with thi investment The investment also nclodes 360,090 pounds from the Welsh Government rs eed a TE — Wasdel’sBursey site is elready home to two Noack 920 blister reckaging machines Industry Events (2/2) [MSM Poly is making progress with ts specialty resin designed to replace the discontinued Barex + The company hae already 2pert$ 75 milion and would be spending anather$ 15 millon by end of 2038 — Anobe's undergoing vaidetion in Euroge, orth America, and Japan t's already dstributed in Europe by VELOX GmbH Ld Impact on industry ‘The company is expanding clean room capabilities in Gabway, eland; Heredia, Costa Rca; and Venray, the Netherlands. 0 * The companyhas also completed a lass 100,000 clean scom accion nits Phoenix facity tohouse a Sencorp ‘thermoforming system “Teli Plex + Allatherm SpA Impact on industry ‘The company acquired the sel adhesive tape substrate operations of Aifatherm SpA of Venegono Superiore (VAY, Italy. + The compan will no be a partof Tekri-Plex Galezi operations intel This sexrected to boost Tekni-len’s presence n Europe Honeywell, the global producer of Aclar, announced its expancian plans for Aclar with the rising demand, + Noteworthy trends, such as cost nd desian ae driving the excansions and upgrades ‘Aclar fms could enable pack ize reductions of upto 55 percent, compared with packs made from coléferm foil Innovations — Product (1/2) Features | Teknfms ‘thermotormable fim for pharmaceutical ster packs ies termed as 8c 240 andi crested using Plynylldane Clorde(Pv

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