41

DAFTAR PUSTAKA

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2. Bakris GL, Black HR, Cushman WC, Green LA, Jones DW, Oparil S, et al.
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 42

Neurology. S 2014;5 :434-437

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22. Di H, Bocor D, Pesantren KB, Kebumen K, Tengah J, Sigarlaki HJO.

Karakteristik Dan Faktor Berhubungan Dengan Hipertensi Di Desa Bocor,
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23. Gorelick PB, Nyenhuis D, Materson BJ, Calhoun DA, Elliott WJ, Phillips
RA, et al. Blood pressure and treatment of persons with hypertension as it
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http://www.ashjournal.com/article/S1933171112001908/fulltext

24. Trail M, Test M. The Montreal Cognitive Assessment ( MoCA ): Concept

and Clinical Review. 2012;(10).

25. Hartawan, Jerry. Hubungan Jumlah Limfosit Total dan Limfosit CD4+
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26. Hill L, Anaesthesia S. Cerebral Blood Flow And Intracranial Pressure.

2011;4:335-340

27. Sherwood L. Fisiologi Manusia Dari Sel ke Sistem. Jakarta: ECG Medical
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28. Köhler S, Baars MA, Spauwen P, Schievink S, Verhey FR, van Boxtel MJ.
Temporal evolution of cognitive changes in incident hypertension:
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29. Kuller LH, Margolis KL, Gaussoin SA, Bryan NR, Kerwin D, Limacher M,
Wassertheil-Smoller S, Williamson J, Robinson JG; Women’s Health
Initiative Memory Study Research Group. Relationship of hypertension,
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Blood Pressure, and Blood Pressure Control with White Matter

Abnormalities in the Women’s Health Initiative Memory Study (WHIMS)-
MRI trial. Clin Hypertens (Greenwich). 2010;12:203–212.
30. Rotar, O, Moguchaya, E, Alieva, A, Orlov, A, Boyarinova, M, Vasilieva,
E, Solntsev, V, Konradi, A.O. Gender Differences of the Cognitive
Function in the Elderly.
31. Katherine A. Lin, Kingshuk Roy Choudhury, Bharath G. Rathakrishnan,
David M. Marks, Jeffrey R. Petrella, P. Murali Dorais. Marked Gender
Differences in Progression of Mild Cognitive Impairment Over 8 Years.
32. Balitbangkes Departemen Kesehatan RI. Riset Kesehatan Dasar
(Riskesdas) 2007. Jakarta: Departemen Kesehatan RI.
33. Manfredini F, Malagoni AM, Mandini S, Boari B, Felisatti M, Zamboni
P, Manfredini R. Sport Therapy for Hypertension: Why, How, and How
Much? Angiology. 2009;60(2):207-16.
34. Nishiguchi S, Yamada M, Tanigawa T, Sekiyama K, Kawagoe T, Suzuki
M, et al. A 12-Week Physical and Cognitive Exercise Program Can
Improve Cognitive Function and Neural Efficiency in Community-
Dwelling Older Adults: A Randomized Controlled Trial. J Am Geriatr
Soc. 2015 Jul;63(7):1355-63.
35. Ratey JJ, Loehr JE. The positive impact of physical activity on cognition
during adulthood: a review of underlying mechanisms, evidence and
recommendations. Rev Neurosci. 2011;22(2):171-85.
36. L.B. Zahodne, MS,1 M.M. Glymour, ScD,2 C. Sparks, BS,3 D. Bontempo,
PhD,4 R.A. Dixon, PhD,5 S.W.S. MacDonald, PhD,3 and J.J. Manly, PhD.
Education Does Not Slow Cognitive Decline with Aging: 12-Year
Evidence from the Victoria Longitudinal Study.
 45

Lampiran 1. Ethical Clearance dari KEPK

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 46

Lampiran 2. Lembar Informed Consent

 47

Lampiran 2. Lembar Informed Consent

penelitian yang saya lakukan ini bersifat sukarela dan tidak ada unsur paksaan' Partisipasi

hal-hal yang merugikan Anda dalam

Anda dalam penelitian ini juga tidak akan digunakan dalam

ini akan diiamin kerahasiaannyq yaitu

bentuk apapun. Data yang didapatkan dari penelitian
tersebut hanya akan saya gunakan
identitas subyek penelitian tidak akan dicantumkan dan data

pengetahuan'
untuk kepentingan penelitian, pendidikan, dan ilmu

Penanggung j awab penelitian adalah:

Adinda Wafdani Putri

Bagian Ilmu Neurologi RSUP Dr' Kariadi Semarang
Jl. Dr Sutomo No. 16 Telepon 024-76928010 ert7771
HP.081212123161

dengan ini saya menyatakan

Sudah mendengar dan memahami penjelasan penelitian,

SETUJU / TIDAK SETUJU

untuk ikut sebagai subyek/sampel penelitian ini'

Semarang, ..'2016

Saksi

Nama Terang
Nama Terang
Alamat Alamat
 48

Lampiran 3. Kuisioner Montreal Cognitive Assessment Test Indonesia

(MoCA)
7.1 Montreal Cognitive Assessment

MoGA Ina
MONTREAL COGNITIW ASSESSMENT
Versi Indonesia (MoCA-Ina)

KEMAMPUANMENGENALRUANGDANBENTUK/MELAKSANAKANTUGAS

Meneiusuri J eiak Secara Bergantian

AkhiL (r\r ,G)

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llerttLrkiarili )Arlg'Lla( ) 'ia;'''imJa:-'i( ) , \ i\ilal r

 49

Lampiran 3. Kuisioner Montreal Cognitive Assessment Test Indonesia

5

PENAMAAN

t1

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DAYA INGAT
WAJAH- SUTER{ * MASJID- ANGGRE,K - MERAI_I
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Tidak ada nilai
PERHATIAN
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2. Subyek harus rneuyebutkan kernbali angka-angka tersebut deugan urutan terbalik
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nilai biia kesalahan > 2
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( ) Nilai 1

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 50

Lampiran 4. Kuisioner Pertanyaan Penelitian

KUESIONER PENELITIAN

NO ANAMNESIS VALUE
Nama

T tr
1

2 Jenis kelamin :
1. Laki-laki 2. Perempuan 1 2
3 Umur (tahun)

4 Alamat

5 No. Telp / I{P

6 Olahraga yang
(meniQ
1. lx / minggu
rutin dilakukan, durasi
lfl 3E
2. lx - 3x / minggu 2 Durasi
3. >3x lminggu L_l
-
7 Status pernikahan :
1. Nikah 3. Tak nikah/belum nikah
2. Duda/ianda
8 Pendidikan Terakhir:
1. SD 3. SMA/SMK rE 3'l=-l'
2. SMP 4. Universitas
,I 4fl
9 Obat antihipertensi yang dikonsumsi
(sebutkan)

10 Obat.obatan lain yang dikonsumsi

(kegunaan obat, sebutkan)
11 Tekanan darah saat ini

12 Nadi

13 Pernafasan
 51

Lampiran 5. Surat Izin Melaksanakan Penelitian

/

I.:EMEN'T'ETTIA IY KES EHAl]Ai\ RI

DIREKTORAT .,IINDERAL BiNA UPAYA KISEHATAN ,)
itUMAH SAKIT UMUM PUSAT DOKTEIi KARIADI (
Jl. Dr Sutomo No. 16 Semarang, pO Box i,l0,t
Telepcn : (029 8413416 Fax : (024) 8318617
' RiUP Dr.KARtADt

Websi
Q 9l*kttru".i.Su*r
e : http://wrvw.rskariadi.co,id email humas-rskariadi@yahoo,co.id
info@rskariadi.co.id

SURAT IZIN
M E LA K sA NAK AI!_B.E N EUII A N
DL 00 02 / t it / ts(9 t 2016

Yang belanda tangan clr irar,t,ah ini

Nl anr; dr Darwrto Sil Sp.B,Sp B(K)Onk
NJ IP 1 9600203 1 98803 1 003
Jabat an Drrektur Medik dan Keperawatan RSUI) Dr. Kariadi
Mernber kan izin melakukan penelitian untuk :

Nlama Perrelrti Adrnda \A/afcianr putri

Ittstitt si trakultas Kedokteran UNDIP

Jt'tdul peneliiian Perl,,andingart Fungsi Kognitif Pacla Penderita Hipertensi Terkontrol
dan Trdak Terkontrol
Lokas i peneiitian . Poir p!,t.*'4611 }AlArn

Untuk tnelaksanakan kegratan penelrtian selama 4 bulan, terhitung rnulai sejak

diterbitkirnnya surat izrn penelitian inr

Peneliti 'vajib :

'1 Mel;rmpirkan lnforntect consenl pada

rekam medis responden
2. Mel;iporkan monitoring evaluasr penelitian secara periodik ke Bagian Diklit
3 Mergumpulkan Laporan selesai penelitian dengan menyerahkan monitor-ing evaluasi
pen,:litian ke Bagian Diklit
4 Meryerahkan laporan hasil akhir penelitian tl berkas)
t'

Semarang, ?AAfRlOt$
An Direktur Utanrrr
Direktur Meclik dan Keperawatan
I

dr Darwito Sl-1 Sp.B,Sp.B(KtOnts/

NtP 1960020t1 198803 1 003 u
 52

Lampiran 6. Output Hasil Program Statistik

Frequencies
Jenis Kelamin

Frequency Percent Valid Percent Cumulative

Percent

Laki-laki 10 35.7 35.7 35.7

Valid Perempuan 18 64.3 64.3 100.0

Total 28 100.0 100.0

Descriptive Statisiks

N Minimum Maximum Mean Std. Deviation

Usia (Tahun) 28 45.0 65.0 54.286 6.6991

Valid N (listwise) 28

Descriptive

Statistics

Olahraga Minum Obat Jumlah Obat

Valid 28 28 28
N
Missing 0 0 0

Frequency Table
Olahraga

Frequency Percent Valid Percent Cumulative

Percent

Tidak olahraga 11 39.3 39.3 39.3

1x / Minggu 4 14.3 14.3 53.6

Valid 1x - 3x / Minggu 2 7.1 7.1 60.7

>3x / Minggu 11 39.3 39.3 100.0

Total 28 100.0 100.0

Minum Obat
 53

Frequency Percent Valid Cumulative Percent

Percent

Tidak minum obat 1 3.6 3.6 3.6

antihipertensi

Valid Minum obat 27 96.4 96.4 100.0

antihipertensi

Total 28 100.0 100.0

Jumlah Obat

Frequency Percent Valid Percent Cumulative Percent

0 1 3.6 3.6 3.6

1 13 46.4 46.4 50.0

Valid 2 11 39.3 39.3 89.3

3 3 10.7 10.7 100.0

Total 28 100.0 100.0

Pendidikan

Frequency Percent Valid Percent Cumulative Percent

SD 4 14.3 14.3 14.3

SMP 5 17.9 17.9 32.1

Valid SMA/SMK 10 35.7 35.7 67.9

Universitas 9 32.1 32.1 100.0

Total 28 100.0 100.0

Descriptive Statistics

N Minimum Maximum Mean Std. Deviation

Sistolik 28 120 240 150.50 28.088

Diastolik 28 58 150 91.71 19.571
Valid N (listwise) 28

Descriptive Statistics
 54

N Minimum Maximum Mean Std. Deviation

Skor MoCA-Ina 28 15 28 22.18 3.289

Valid N (listwise) 28

Fungsi Kognitif

Frequency Percent Valid Percent Cumulative Percent

Normal 6 21.4 21.4 21.4

Valid Terganggu 22 78.6 78.6 100.0

Total 28 100.0 100.0

Descriptives

Statistic Std. Error

Mean 14.86 .723

95% Confidence Interval for Lower Bound 13.37

Mean Upper Bound 16.34

5% Trimmed Mean 15.13

Median 16.00

Variance 14.646
Skor MoCA-
Std. Deviation 3.827
Ina
Minimum 5

Maximum 19

Range 14

Interquartile Range 6

Skewness -.907 .441

Kurtosis .053 .858

Tests of Normality
a
Kolmogorov-Smirnov Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Skor MoCA-Ina .225 28 .001 .894 28 .008

a. Lilliefors Significance Correction

Skor MoCA-Ina
 55

Ranks

Hipertensi Terkontrol N Mean Rank Sum of Ranks

Terkontrol 12 13.04 156.50

Skor MoCA-Ina Tidak Terkontrol 16 15.59 249.50

Total 28

a
Test Statistics

Skor MoCA-Ina

Mann-Whitney U 78.500
Wilcoxon W 156.500
Z -.819
Asymp. Sig. (2-tailed) .413
b
Exact Sig. [2*(1-tailed Sig.)] .423

a. Grouping Variable: Hipertensi Terkontrol

b. Not corrected for ties.

Crosstabs

Fungsi Kognitif * Hipertensi Terkontrol Crosstabulation

Count

Hipertensi Terkontrol Total

Terkontrol Tidak Terkontrol

Normal 4 2 6
Fungsi Kognitif
Terganggu 8 14 22
Total 12 16 28

Skor MoCA-Ina

Hipertensi Terkontrol Mean Std. Deviation Median Minimum Maximum

Terkontrol 14.17 4.196 16.00 5 19

Tidak Terkontrol 15.38 3.575 16.50 9 19
Total 14.86 3.827 16.00 5 19

Hipertensi Terkontrol

Frequency Percent Valid Percent Cumulative

Percent

Terkontrol 12 42.9 42.9 42.9

Valid Tidak Terkontrol 16 57.1 57.1 100.0

Total 28 100.0 100.0

 56

b
Continuity Correction .747 1 .387
Likelihood Ratio 1.763 1 .184
Fisher's Exact Test .354 .194
Linear-by-Linear Association 1.705 1 .192
N of Valid Cases 28

a. 2 cells (50.0%) have expected count less than 5. The minimum expected count is 2.57.
b. Computed only for a 2x2 table

Crosstabs

Jenis Kelamin * Hipertensi Terkontrol Crosstabulation

Hipertensi Terkontrol Total

Terkontrol Tidak
Terkontrol

Count 5 5 10
Laki-laki % within Jenis 50,0% 50,0% 100,0
Kelamin %
Jenis Kelamin
Count 7 11 18
Perempuan % within Jenis 38,9% 61,1% 100,0
Kelamin %
Count 12 16 28
Total % within Jenis 42,9% 57,1% 100,0
Kelamin %

Chi-Square Tests

Value df Asymp. Sig. Exact Sig. Exact Sig.

(2-sided) (2-sided) (1-sided)
a
Pearson Chi-Square ,324 1 ,569
b
Continuity Correction ,029 1 ,864
Likelihood Ratio ,323 1 ,570
Fisher's Exact Test ,698 ,430
Linear-by-Linear Association ,313 1 ,576
N of Valid Cases 28

a. 1 cells (25.0%) have expected count less than 5. The minimum expected count is 4.29.
b. Computed only for a 2x2 table
 57

Crosstabs

Olahraga * Hipertensi Terkontrol Crosstabulation

Hipertensi Terkontrol Total

Terkontrol Tidak
Terkontrol

Count 5 6 11
Tidak olahraga
% within Olahraga 45,5% 54,5% 100,0%

Count 2 2 4
1x / Minggu
% within Olahraga 50,0% 50,0% 100,0%
Olahraga
Count 1 1 2
1x - 3x / Minggu
% within Olahraga 50,0% 50,0% 100,0%

Count 4 7 11
>3x / Minggu
% within Olahraga 36,4% 63,6% 100,0%
Count 12 16 28
Total
% within Olahraga 42,9% 57,1% 100,0%

Chi-Square Tests

Value df Asymp. Sig.

(2-sided)
a
Pearson Chi-Square ,345 3 ,951
Likelihood Ratio ,346 3 ,951
Linear-by-Linear Association ,191 1 ,662
N of Valid Cases 28

a. 6 cells (75.0%) have expected count less than 5. The minimum expected count is
.86.
 58

Crosstabs

Minum Obat * Hipertensi Terkontrol Crosstabulation

Hipertensi Terkontrol Total

Terkontrol Tidak
Terkontrol

Count 0 1 1
Tidak minum obat
% within Minum 0,0% 100,0% 100,0%
antihipertensi
Obat
Minum Obat
Count 12 15 27
Minum obat
% within Minum 44,4% 55,6% 100,0%
antihipertensi
Obat
Count 12 16 28
Total % within Minum 42,9% 57,1% 100,0%
Obat

Chi-Square Tests

Value df Asymp. Sig. Exact Sig. Exact Sig.

(2-sided) (2-sided) (1-sided)
a
Pearson Chi-Square ,778 1 ,378
b
Continuity Correction ,000 1 1,000
Likelihood Ratio 1,147 1 ,284
Fisher's Exact Test 1,000 ,571
Linear-by-Linear Association ,750 1 ,386
N of Valid Cases 28

a. 2 cells (50.0%) have expected count less than 5. The minimum expected count is .43.
b. Computed only for a 2x2 table
 59

Crosstabs

Jumlah Obat * Hipertensi Terkontrol Crosstabulation

Hipertensi Terkontrol Total

Terkontrol Tidak
Terkontrol

Count 0 1 1
0
% within Jumlah Obat 0,0% 100,0% 100,0%

Count 7 6 13
1
% within Jumlah Obat 53,8% 46,2% 100,0%
Jumlah Obat
Count 4 7 11
2
% within Jumlah Obat 36,4% 63,6% 100,0%

Count 1 2 3
3
% within Jumlah Obat 33,3% 66,7% 100,0%
Count 12 16 28
Total
% within Jumlah Obat 42,9% 57,1% 100,0%

Chi-Square Tests

Value df Asymp. Sig.

(2-sided)
a
Pearson Chi-Square 1,692 3 ,639
Likelihood Ratio 2,058 3 ,560
Linear-by-Linear Association ,195 1 ,659
N of Valid Cases 28

a. 5 cells (62.5%) have expected count less than 5. The minimum expected count is
.43.

Means
Report
Skor MoCA-Ina

Hipertensi Terkontrol

Terkontrol Tidak Total

Terkontrol

Mean 22,50 21,94 22,18

Std. Deviation 3,317 3,356 3,289
Median 24,00 23,00 23,50
Minimum 15 16 15
Maximum 25 28 28
 60

Skor MoCA-Ina

Statistic S
t
d
.
E
r
r
o
r

22,18 ,
6
Skor MoCA-Ina Mean
2
2
 61

L 20,90
o
w
e
r
B
o
u
n
d
95% Confidence Interval for Mean
U 23,45
p
p
e
r
B
o
u
n
d

5% Trimmed Mean 22,29

Median 23,50

Variance 10,819

Std. Deviation 3,289

Minimum 15

Maximum 28

Range 13

Interquartile Range 5

-,789 ,
4
Skewness
4
1

-,217 ,
8
Kurtosis
5
8

Tests of Normality
 62

a
Kolmogorov-Smirnov Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Skor MoCA-Ina ,241 28 ,000 ,885 28 ,005

a. Lilliefors Significance Correction

Skor MoCA-Ina
NPar Test

Mann-Whitney Test

Ranks

Hipertensi Terkontrol N Mean Rank Sum of Ranks

Terkontrol 12 16,04 192,50

Skor MoCA-Ina Tidak Terkontrol 16 13,34 213,50

Total 28

a
Test Statistics

Skor MoCA-
Ina

Mann-Whitney U 77,500
Wilcoxon W 213,500
Z -,873
Asymp. Sig. (2-tailed) ,383
b
Exact Sig. [2*(1-tailed Sig.)] ,397

a. Grouping Variable: Hipertensi Terkontrol

b. Not corrected for ties.

Crosstabs
Fungsi Kognitif * Hipertensi Terkontrol Crosstabulation

Hipertensi Terkontrol Total

Terkontrol Tidak
Terkontrol

Count 4 2 6
Normal % within Fungsi 66,7% 33,3% 100,0%
Fungsi Kognitif
Kognitif

Terganggu Count 8 14 22
 63

% within Fungsi 36,4% 63,6% 100,0%

Kognitif
Count 12 16 28
Total % within Fungsi 42,9% 57,1% 100,0%
Kognitif

Chi-Square Tests

Value df Asymp. Sig. Exact Exact

(2-sided) Sig. (2- Sig.
sided) (1-
sided)
a
Pearson Chi-Square 1,768 1 ,184
b
Continuity Correction ,747 1 ,387
Likelihood Ratio 1,763 1 ,184
Fisher's Exact Test ,354 ,194
Linear-by-Linear Association 1,705 1 ,192
N of Valid Cases 28

a. 2 cells (50.0%) have expected count less than 5. The minimum expected count is 2.57.
b. Computed only for a 2x2 table

Crosstabs

Pendidikan * Hipertensi Terkontrol Crosstabulation

Hipertensi Terkontrol Total

Terkontrol Tidak
Terkontrol

Count 2 2 4
SD
% within Pendidikan 50,0% 50,0% 100,0%

Count 2 3 5
SMP
% within Pendidikan 40,0% 60,0% 100,0%
Pendidikan
Count 4 6 10
SMA/SMK
% within Pendidikan 40,0% 60,0% 100,0%

Count 4 5 9
Universitas
% within Pendidikan 44,4% 55,6% 100,0%
Count 12 16 28
Total
% within Pendidikan 42,9% 57,1% 100,0%
 64

Chi-Square Tests

Value df Asymp. Sig.

(2-sided)
a
Pearson Chi-Square ,143 3 ,986
Likelihood Ratio ,142 3 ,986
Linear-by-Linear Association ,011 1 ,917
N of Valid Cases 28

a. 6 cells (75.0%) have expected count less than 5. The minimum expected count is
1.71.