Professional Documents
Culture Documents
Organic Chemistry 307: Chapter 3 Lecture Notes
Organic Chemistry 307: Chapter 3 Lecture Notes
Organic Chemistry 307: Chapter 3 Lecture Notes
a. Most (but not all) bond making and bond breaking tends to be
associated with a functional group.
b. Two types of bond breaking (oversimplified)
ii. Homolytic, each atom brings an electron (note that each atom must
therefore have an odd number of valence shell electrons.
1
show what happens to them using curved arrows, in more or
less the same way we use curved arrows to work out
contributing resonance structures. (V&S Section 1.5). Being
able to use curved arrows to show reaction mechanisms and
contributing structures is one of the key skills you must master
in order to succeed in this course.
An arrow with one hook tracks one electron, with two hooks tracks
an electron pair. The direction of the arrow is always the one in
which the electrons are moving.
Key Concepts
a. Free Energy criterion for spontaneity and stability
i. ΔG = ΔH – TΔS discuss H (standard heat of formation and
bond energies) and S (microstates, disorder)
ii. ΔGº = -RTlnK
2
i. rate laws and mechanistic information, rate determining step
ii. Arrhenius and barriers
Because they do not have functional groups, alkanes almost always react
through homolytic mechanisms.
Such reactions begin with a homolytic cleavage of a bond. Homolytic
cleavage of a bond forms odd electron species called free radicals. Free
radicals are very reactive, relatively unstable species, and once formed tend
to lead to a variety of products. Rule: High reactivity = low selectivity. (You
may think of various real life analogies for this rule). Thus these kinds of
reactions are generally (with a number of exceptions) not a good way to
prepare a particular product.
Homolytic cleavage of a bond requires the input of energy. The energy is
generally provided in the form of heat. For substances such as Cl2 or Br2,
that are colored, the energy can also be provided as light of a wavelength
that can be absorbed by the substance. It is better to use light when possible
because it can be much more targeted, giving energy only to a species that
3
can absorb that wavelength of light. Since alkanes are always colorless,
visible light cannot be used to cleave alkane bonds.
B. Bond Strength
How do we explain this trend? Consider isobutane, which has 1°, 2°, and
3° C-H bonds. When we cleave any one of these bonds we start with
isobutane, but form a different free radical in each case. (In other words in
each case we have the same starting material but a different product
Therefore the relative DH° values must reflect the relative stabilities of the
free radicals. The more stable the free radical, the easier it is to break a C-H
bond to form it; that is the lower is DH°. So the order of stability of free
radicals is 3° > 2° > 1° > .CH3. [Figure 3.1]
How do we explain this order of stability? Why is a free radical relatively
unstable? Because it is electron deficient; it has an incomplete octet. How do
we stabilize an electron deficient species? By feeding electron density
4
toward the center of electron deficiency from elsewhere in the species
thereby distributing the electron deficiency over a larger area.
The way in which electron density is fed toward the C with the incomplete
octet (the one with the dot) is called hyperconjugation. We picture the C
with the dot as sp2 hybridized with the single electron in an unhybridized p-
orbital.[Figure 3.2] This unhybridized p-orbital can overlap with the orbitals
of σ-bonds to adjacent C atoms. The more adjacent C’s the more
hyperconjugation and the more the free radical is stabilized. [Figure 3.3]
This trend in radical stability also controls the way in which C-C bonds
(which are weaker than C-H bonds) break. When an alkane is heated, the C-
C bonds will cleave before the C-H bonds because the C-C bonds are
weaker. As a result heating alkanes gives mixtures of products with different
carbon skeletons. Such reactions are not useful if we want to make a specific
compound or a few specific compounds. They can be useful in petroleum
chemistry, however.
D. Halogenation of Alkanes
5
a. Initiation.
Once formed, a highly reactive free radical seeks to form a bond with
anything that can bring an electron. What is most available are the H
atoms bonded to the carbons of the alkane. We can represent the alkane
as RH and the reaction as
RH + Cl. → R. + H-Cl
6
product of the reaction is actually a new compound. The alkane has been
transformed into an alkyl halide, The other product of the reaction is the
Cl., which started this two step sequence. This two step sequence called
propagation will keep repeating as long as there are Cl2 and C-H bonds
remaining. Unless some other reaction can take place to get rid of the free
radicals. It is because of this repeat that the reaction is called a free
radical chain mechanism. Notice that the sum of the two propagation
steps is always the overall stoichiometry of the reaction:
c. Termination
Questions:
a. What about the other halogens? A bond energy
analysis of the propagation steps helps rationalize the
behavior of the other halogens. (You can find these
bond energies in Table 3.1)
7
unless selectivity is not an issue and we take special care
to control conditions.
For a given alkane, there are two factors that determine the mixture of
monohalogenated products under a given set of conditions. One is the
relative reactivity of the different hydrogens. Remember those that form
8
the more stable radicals have weaker bonds and are also more reactive
(more easily abstracted by the X..)
The other factor is the number of each type of H, the statistics. For
example the two kinds of H in propane are in the ratio of 6:2. So if they
had the same reactivity (which they do not) the 1° H would be 3 times
more likely to react.
The exact quantitative relative reactivities of the H’s depend on several
factors in addition to whether they are 1°, 2°, or 3°. First, as we have
already seen the selectivity is greater for Br2 than for Cl2. Second the
reaction conditions have an important effect on relative reactivity. Milder
conditions (lower temperature) enhance selectivity. Therefore we can
find the relevant relative reactivities only by measuring them under the
given conditions. A rough rule of thumb is that for Cl2 at room
temperature (25 °C) the reactivity ratio of 3°:2°:1° hydrogens is 5:4:1.
Energy diagrams such as those in Figures 3.1 and 3.12 are very useful
in helping us to understand and analyze relative stabilities as well as the
relationship between structure and stability. Later on we will use this
approach to help us understand resonance energy and strain energy. So you
should learn how to construct and interpret these kinds of diagrams.
a. They are not really graphs, only the y-axis has meaning. It shows
increasing energy (or enthalpy). Remember that high energy or
enthalpy is bad and low is good. So lower on the page is more
stable and higher on the page is less stable
9
b. Ideally, we want to compare processes that either start or finish
with the same substances.
10