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E - Uniform Round Tumour Cells With Small Nucleus and Clear Vacuolated Cytoplasm
E - Uniform Round Tumour Cells With Small Nucleus and Clear Vacuolated Cytoplasm
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4. A 6-year-old girl was found to be unsteady while walking. MRI scan
showed a tumour in the right cerebellar hemisphere. The tumour was
resected. Histologically, it was composed of densely packed
undifferentiated “small round blue cells” arranged in solid sheets.
Frequent mitoses and tumour necrosis were seen. Select the most
likely diagnosis.
A. Medulloblastoma
B. Pilocytic astrocytoma
C. Craniopharyngioma
D. Haemangioblastoma
E. Germinoma
A. Ependymoma
B. Neurofibroma
C. Craniopharyngioma
D. Metastatic carcinoma
E. Schwannoma
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CASE 1: Glioblastoma
Grading is based on presence of the following four histological criteria:
Nuclear atypia (pleomorphism),
mitoses,
endothelial proliferation,
necrosis.
If only one of these criteria is found the tumor is a Grade II.
Two of the criteria make the tumor a Grade III
and if three or four of the criteria are found the tumor is a Grade IV or
Glioblastoma.
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CASE 2: Meningioma
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4. What is the presumed cell of origin of common nervous system
tumours?
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4. State the effects and complications of brain tumour (in general) as a
space-occupying-lesion (SOL).
•3.Destruction.
Invasive tumours may destroy or stimulate nerve cells and produce the same symptoms
as those tumors that are compressing the brain.
5.Cerebral edema.
- It is typical response to all intracranial pathologic processes. Brain edema involves the
peritumoral brain tissue but also parts of the brain at a distance from the tumor.
8.Headaches:
The most common site for headache in brain tumour is bifrontal.
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CASE 3: Schwannoma
body).
Infratentorial tumors (posterior fossa), i.e., tumors of the cerebellum and the brain stem
located underneath the tentorium cerebelli. Most brain tumors in children ( two-thirds or
70%) are found in this location.
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CASE 4: Medulloblastoma
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PICTURE A
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PICTURE B
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PICTURE C
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PICTURE D
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PICTURE E
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Picture F
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PICTURE G
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