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Aesthetic Trends and Technologies Formula 82M Special Report (Sept 2010)
Aesthetic Trends and Technologies Formula 82M Special Report (Sept 2010)
special report
Formula 82M
for Hair
Regrowth
atnt
A UNIQUELY ENGINEERED
FORMULATION PROVIDING
AN ALTERNATIVE SOLUTION
FOR ALOPECIA PATIENTS
Male pattern hair loss More recent therapies for 3. It increases proliferation
(androgenetic alopecia) is a androgenetic alopecia have of dermal papilla cells in
significant cosmetic concern, with focused on blocking 5 alpha the hair follicle.
50% of men over 50 years of age reductase (such as the oral use of 4. It enhances cell
being affected. In the U.S. there finasteride, propecia). proliferation.
are over 50 million men afflicted Minoxidil has been the
with this condition. Androgenetic number one topical therapy for Studies with topical
alopecia is a genetically driven androgenetic alopecia since its minoxidil 2% or 3% show that
condition. DHT FDA clearance in 1988. Even hair regrowth tends to peak at
(dihydrotestosterone) appears to after years of use, its exact mode around 1 year and that new non-
be the trigger for androgenetic of action is not completely vellus hairs were maintained at 4.5
alopecia in genetically-prone understood. Minoxidil sulfate is – 5 years with ongoing use of the
individuals. Testosterone is the active metabolite which has product. In addition to stimulating
converted to DHT by the enzyme been shown to stimulate hair the growth of new hairs, minoxidil
5 alpha reductase. Once formed, growth. was also shown to increase the
DHT attaches to the hair follicle The proposed diameter of the individual hair
and triggers the process of mechanisms of action for shafts by over 30%. A
miniaturization of the hair follicle. minoxidil are: randomized, placebo controlled
As the follicle is miniaturized, the comparison study of topical 5%
hair shaft diameter decreases until 1. It creates vasodilatation. minoxidil vs. topical 2% minoxidil
the normal terminal hair becomes 2. It slows senescence of showed the men in the 5%
a fine vellus hair, like peach fuzz. keratinocytes. minoxidil group had 45%
than those men using 2% cells and induce protein synthesis improve hair growth. Over 15
minoxidil. and cell turnover. Additionally, it years ago, a pharmaceutical group
prolongs cell survival and prevents in South America created several
apoptosis of dermal papilla cells. topical formulas containing
INCREASED HAIR GROWTH After years of clinical use, minoxidil, tretinoin, a topical
WITH TRETINOIN AND it appears that patients with the steroid, and more recently, a
MINOXIDIL most recent hair loss have the natural 5 alpha reductase blocking
There is also evidence that most success with regrowth from agent, oleanolic acid, in addition
tretinoin, when added to minoxidil-containing products. to several other ingredients.
minoxidil, can increase its Therefore, those patients with Additionally, they also developed
efficacy. Studies have shown that partially miniaturized follicles a proprietary method of
tretinoin increases the have the most success in reversing solubilizing and stabilizing
percutaneous absorption of the miniaturizing process. Minoxidil, allowing better stability,
longer shelf life, and better
efficacy.
“This is the first significant recovery product DERMA 5 FORMULATION
that I have seen, and it competes strongly with In 2008 a group of 5
hair transplantation.” dermatologists in Mexico headed
by Dr. Antonio Cueva introduced
– David Michelson, M.D. these formulas to Mexico. They
performed some clinical trials
showing a markedly faster onset
minoxidil by 3 fold. Additionally, Another ingredient that of hair growth and more
tretinoin in one study, when used has been combined with profound hair growth than they
alone, was shown to be able to minoxidil has been topical had seen with previous minoxidil
increase hair growth in 58% of steroids, most commonly based formulas. The attached
patients, while the combination of betamethasone diproprionate. photos document several cases
minoxidil and tretinoin increased The use of topical steroids has showing the rapid and dramatic
hair growth in 66% of subjects. been shown to decrease results of the use of the Derma 5
Another trial showed equal inflammation associated with the product.
efficacy between once a day use of use of minoxidil, tretinoin or the In 2009 I tried the Derma
tretinoin 0.01% mixed with combination of both. Also, the 5 formula on several patients. I
minoxidil 5% compared to twice combination has been shown to purposely picked several
daily use of minoxidil 5%. The have increased efficacy over advanced cases of androgenetic
adverse event profile of both minoxidil alone. Notedly, alopecia. The included photos
formulations was similar. Upjohn, the manufacturer of after only 3 months of use show
Intriguingly, in one study by Minoxidil, has a patent for the the impressive efficacy. These
Lewenberg, it was noted that combined use of minoxidil and early results are particularly
while minoxidil appears to exert topical steroids. significant in view of the fact that
its best hair growing effects on the Blockers of 5 alpha these patients are not considered
vertex of the scalp, the reductase, as previously very good candidates for hair
combination of tretinoin and mentioned, can reverse some regrowth, since they have had
minoxidil “results in hair growth androgenetic alopecia. Topical long-term hair loss with few or no
in all areas of the scalp.” finasteride used alone has been visibly functioning hair follicles.
The mechanism of action shown to have a positive effect on The patients tolerated the therapy
for hair growth from tretinoin is hair growth. Other “natural” 5 well, with only some mild
not clear either. It has been alpha reductase inhibitors have pinkness in 1 patient.