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Toxin

Lethal Toxin Edema Toxin



TLR4 ROS á ATP

SOD
C Amp
MAPKK
JNK Disfungsi Endotel Edema

ERK IKK Necrosis

P38
IKß
NFKß
NADPH
Endotel
TNF-α

VCAM E – Selective
NLRP1
PMN
MMP
Inflamasome Leukosit á
Kompleks
Sel Target
Pro
Caspase 1 Caspase 1
Kulit Paru Gastro-intestinal

IL-1ß
IL- 18 Eschar Hemoptoe Melena/Hematemesis


Apoptosis

Necrosis

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