LIST OF BIOMARKERS

BIOMARKERS ANALYTICAL BIOMARKERS ANALYTICAL

METHODS METHODS

Anemia
Erythropoietin (EPO) Chemiluminescent Reticulocytes Automated Hematology
Immunoassay
Ferritin Chemiluminescent Soluble Transferrin Receptor (sTrR) Immunoturbidimetric
Immunoassay
Folic Acid (folates) Chemiluminescent Transferrin Immunoturbidimetric
Immunoassay
Hemoglobin Colorimetric Unsaturated Iron Binding Capacity (UIBC) Colorimetric
Iron Colorimetric Vitamin B12 Chemiluminescent
Immunoassay
Iron Saturation

Autoimmune Disease
Anti-Double Stranded DNA Ab (dsDNA) ELISA Anti-Sjogren Syndrome Ab (SS-B/La) ELISA
Anti-Nuclear Ab (ANA) ELISA Anti-Ribonucleo Protein Ab (RNP) ELISA
Anti-Smooth Muscle Ab (ASMA) ELISA Anti-Mitochondrial Ab (AMA) ELISA
Anti-Sjogren Syndrome Ab (SS-A/Ro) ELISA Anti-Thyroid Peroxidase Ab (TPO) ELISA

Bone Diseases
Alkaline Phosphatase (ALP) Colorimetric Osteocalcin RIA
Aminoterminal Propeptide Type 1 Collagen RIA Parathyroid Hormone (PTH) Immunochemistry
(PINP)
Bone Specific Alkaline Phosphatase (BSAP) ELISA Tartrate Resistant Acid Phosphatase-5b ELISA
(TRACP5b)
Calcium (Ca) Colorimetric Vitamin D, 1,25 Dihydroxy ELISA
C-Terminal Type I Collagen Telopeptide (CTx) ELISA Vitamin D, 25 Hydroxy ELISA
N-terminal Type I Collagen Telopeptide (NTx) ELISA

Cardiac Markers
Apolipoprotein E (Apo E) Nephelometric Endothelin-1 ELISA
Brain Natriuretic Peptide (BNP) ELISA LDH Colorimetric
CK Colorimetric Potassium Automated Polarization
CKMB Immunochemistry Pro-B-type Natriuretic Peptide (Pro-BNP) ELISA
C-Reactive Protein (CRP) Immunoturbidimetric Troponin I Immunochemistry
CRPhs (ultrasensitive) Immunoturbidimetric

Diabetes
C-Peptide ELISA/RIA HbA1c Immunoturbidimetric/
HPLC
Cholesteryl Ester Transfer Protein (CETP) ELISA IA-2 Antibody ELISA
Free Fatty Acids (FFA) Immunoturbidimetric Insulin Immunochemistry/RIA
Fructosamine Immunoturbidimetric Insulin Growth Factor (IGF-1) ELISA
Glucagon RIA Microalbumin Immunoturbidimetric
Glucose Colorimetric Proinsulin ELISA
Glutamate Decarboxylase-65 ELISA
(GAD-65 ) Antibody
 BIOMARKERS ANALYTICAL BIOMARKERS ANALYTICAL
METHODS METHODS

Endocrinology
Alpha-Foetoprotein Chemiluminescent Growth Hormone ELISA
Immunoassay
Adrenal Corticotrophic Hormone (ACTH) ELISA Growth Releasing Factor (GRF) ELISA
Corticosterone RIA Prolactin ELISA
Cortisol Chemiluminescent Testosterone Chemiluminescent
Immunoassay Immunoassay
Follicle Stimulating Hormone (FSH) Chemiluminescent
Immunoassay

Gastroenterology
Gastrine ELISA Lipase Enzymatic

Infectious Diseases
Anti HBs Immunometric Hepatitis B Viral Load (quantitative) RT-PCR
Anti-HBc Immunometric Hepatitis C Genotype PCR
Anti-Hbe Immunometric Hepatitis C Viral Load (qualitative) PCR
Anti-HCV Immunometric Hepatitis C Viral Load (quantitative) RT-PCR
Anti-HIV I/II Immunometric HIV Viral Load (quantitative) RT-PCR
Chlamydia Trachomalis PCR Mononucleosis Agglutination - manual
Cytomegalovirus (CMV) PCR Mycobacterium Tuberculosis PCR
HBsAg Immunometric Neissera Gonorrhoea PCR

Inflammation/Immunity
CD Cell Markers* Flow Cytometry Immunoglobulins (IgA, IgG, IgM) Immunoturbidimetric
Clusterin (Apolipoprotein J) ELISA Intra-Cellular Adhesion Molecule-1 Electrocheminumiles-
(ICAM-1) - 2plex cence Immunoassay
C-Reactive Protein (CRP) Immunoturbidimetric IP-10 (IL-12p70) - 2-plex xMAP - Luminex
CRPhs (ultrasensitive) Immunoturbidimetric ISG15 gene expression PCR
Endothelin-1 ELISA ISG56 gene expression PCR
Fibrinogen Coagulometry Macrophage Inflammatory Protein (MIP 1Į ) xMAP - Luminex
Glucose-6-Phosphate Dehydrogenase Colorimetric Macrophage Inflammatory Protein (MIP 1ȕ ) xMAP - Luminex
(G-6-PDH)
HLA-A PCR Matrix Metalloproteinase-2 (MMP-2) xMAP - Luminex
HLA-B PCR Matrix Metalloproteinase-9 (MMP-9) xMAP - Luminex
HLA-C PCR Monokine Induced by IFNȖ (MIG/CXCL9) ELISA
IFN-alpha ELISA Neopterin ELISA
IFNȖ (IL-2,IL-4-IL-10) - 4-plex xMAP-Luminex OAS1 gene expression PCR
IL-10 ELISA OAS2 gene expression PCR
IL-10 (IL-2,IL-4,IFNȖ) - 4-plex xMAP - Luminex OAS3 gene expression PCR
IL-1ȕ ELISA Rantes/CCL5 xMAP - Luminex
IL-2 (IL-4,IL-10-IFNȖ) - 4-plex xMAP- Luminex Serum Amyloid Protein (SAA) Nephelometric
IL-4 (IL-2,IL-10,IFNȖ) - 4-plex xMAP- Luminex Tumor Growth Factor (TGF-ȕ1) ELISA
IL-6 Electrocheminumilescence Tumor Necrosis Factor (TNFĮ) Electrocheminumiles-
Immunoassay/ELISA cence Immunoassay/
ELISA
IL-8 xMAP-Luminex/ELISA Vascular Adhesion Molecule-1 Electrocheminumiles-
(VCAM-1)- 2 plex cence Immunoassay
 BIOMARKERS ANALYTICAL BIOMARKERS ANALYTICAL
METHODS METHODS

Lipid Metabolism
Apolipoprotein AI (Apo AI) Nephelometric Cholesterol Colorimetric
Apolipoprotein AII (Apo AII) Nephelometric HDL-Cholesterol Immunoturbidimetric
Apolipoprotein B-100 (Apo B) Immunoturbidimetric LDL-Cholesterol (Direct) Enzymatic
Apolipoprotein B48 (Apo B48) ELISA Lecithin Cholesterol Acyltransferase (LCAT) ELISA
Apolipoprotein CII (Apo CII) Immunoturbidimetric Paraxonase (PON1) UV/Colorimetric
Apolipoprotein CIII (Apo CIII) Immunoturbidimetric Phosphatidyl Inositol Glycan F (PIGF) ELISA
Apolipoprotein E (Apo E) Nephelometric Triglycerides Colorimetric

Nephrology
Alpha-GST ELISA Glomerular Filtration Rate
Beta-2-Microglobulin (serum) Immunoturbidimetric Microalbumin Immunoturbidimetric
Beta-2-Microglobulin (urine) ELISA N-Acetylȕ-Glucosaminidase (NAG) Enzymatic
Collagen Type IV ELISA Pi-GST ELISA
Creatinine Colorimetric

Oncology
Bcl-2/IGH PCR Placenta Growth Factor (PlGF) ELISA
Carbohydrate Antigen 19-9 (CA19-9) Immunochemistry Prostate Specific Antigen (PSA) Chemiluminescent
Immunoassay
Carcinogenic Embryonic Antigen (CEA) Chemiluminescent Vascular Endothelial Growth Factor (VEGF) ELISA
Immunoassay
Fibroblast Growth Factor (FGFb) ELISA

Thyroid Markers
Anti-Thyroid Peroxidase Ab (TPO) ELISA Thyroid Stimulating Hormone (TSH) Immunochemistry
Anti-Thyroglobulin Ab ELISA Total Thyroxin (T4) Immunochemistry
Free Thyroxin (FT4) Immunochemistry Total Triiodothyronin (T3) Immunochemistry
Free Triiodothyronin (FT3) Immunochemistry TSH Receptor Ab RIA
Thyroglobulin ELISA

*For a complete list of CD Cell Markers, please contact us at: businessdevelopment@cirion.com

The integration of each of our services provides the most accurate results for diagnosis, prognosis
and patient monitoring. For more information regarding biomarkers, other Research and Develop-
ment services and Central Laboratory services, please contact: businessdevelopment@cirion.com

CIRION Clinical Trial Services Inc.

2121 Berlier Street, Laval, QC H7L 3M9 - Tel: 1-866-688-2474 – Fax: 1-450-902-3060

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