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Lichen Planu לאתר תשע)
Lichen Planu לאתר תשע)
(LP)
T-cell-mediated
autoimmune reaction in
which autocytotoxic
CD8+ T cells trigger
apoptosis of the oral
•The lymphocytic infiltrate:
epithelial cells.
T cells (almost exclusively)
Whether the foreign
• Most T cells in the epithelium
antigen is a virus or a and adjacent to the damaged
drug is not known. basal keratinocytes are
activated CD8+ lymphocytes.
This stimulated
lymphocytic infiltrate
which is epidermotropic
and attacks
keratinocytes.
Predominantly affect :
• buccal mucosa,
• tongue,
• gingivae,
• other sites are
occasionally
involved.
• usually bilateral
In patients
predisposed to
pigmentation,
pigmentation
OLP lesions may be
associated with
patchy brown
melanin deposits in
the oral mucosa
(inflammatory
melanosis)
• Stress=exacerbation of OLP
• Eisen D.The clinical features,malignant potential,and systemic
association of oral lichen planus:a study of 723 patients.
J Am Acad Dermatol 2002;46:207-214
• OLP=model for
psychoneuroimmunology research in
oral biology & medicine
• Prolo et al. Psychoneuroimmunology in oral biology and medicine.
The model of oral lichen planus.Ann.N.Y.Acad Sci.2002;966:429-
440
• Aims :
• Resolution of :Painful symptoms -oral
mucosal lesions
• In patients with recurrent painful
disease, prolongation of their symptom-
free intervals .
• Reduction of the risk of oral cancer
• Maintenance of good oral hygiene.
T-cell-mediated
autoimmune reaction in
which autocytotoxic
CD8+ T cells trigger
apoptosis of the oral
•The lymphocytic infiltrate:
epithelial cells.
T cells (almost exclusively)
Whether the foreign
• Most T cells in the epithelium
antigen is a virus or a and adjacent to the damaged
drug is not known. basal keratinocytes are
activated CD8+ lymphocytes.
This stimulated
lymphocytic infiltrate
which is epidermotropic
and attacks
keratinocytes.
Predominantly affect :
• buccal mucosa,
• tongue,
• gingivae,
• other sites are
occasionally
involved.
• usually bilateral
In patients
predisposed to
pigmentation,
pigmentation
OLP lesions may be
associated with
patchy brown
melanin deposits in
the oral mucosa
(inflammatory
melanosis)
• Stress=exacerbation of OLP
• Eisen D.The clinical features,malignant potential,and systemic
association of oral lichen planus:a study of 723 patients.
J Am Acad Dermatol 2002;46:207-214
• OLP=model for
psychoneuroimmunology research in
oral biology & medicine
• Prolo et al. Psychoneuroimmunology in oral biology and medicine.
The model of oral lichen planus.Ann.N.Y.Acad Sci.2002;966:429-
440
• Aims :
• Resolution of :Painful symptoms -oral
mucosal lesions
• In patients with recurrent painful
disease, prolongation of their symptom-
free intervals .
• Reduction of the risk of oral cancer
• Maintenance of good oral hygiene.