PP Mecobalamin

Class Neurotrophic, Vitamin B Complex

Categories Nerve Suplement

Indication Bell’s Palsy

Diabetic Neuropathy
Eye Function
Homocysteinemia
Male Impotence
Sleep Disturbances
Peripheral Neuropathy
Drug induced Neuropathy
Sciatica
Stroke
Osteoporosis

Dosage
Oral
Peripheral neuropathies
Adult: 1500 mcg/day in 3 divided doses.
Parenteral
Peripheral neuropathies
Adult: 500 mcg daily IM/IV 3 times/wk.
Parenteral
Megaloblastic anaemia caused by vitamin B12 deficiency
Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2
mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Administration May be taken with or without food. ( PO, sublingual, parenteral )
Adverse Drug Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache,
Reactions hot sensation, diaphoresis and pain/induration at IM inj site.
Potentially Fatal: Anaphylactoid reactions (parenteral).

Mechanism of Mecobalamin is the neurologically active form of vitamin B12 and occurs as
Action a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine
synthase, which functions to transfer methyl groups for the regeneration of
methionine from homocysteine. In anaemia, it increases erythrocyte
production by promoting nucleic acid synthesis in the bone marrow and by
promoting maturation and division of erythrocytes.
Methylcobalamin works by functioning in the production of a material called
myelin, which covers and protects nerve fibers. Without enough
Methylcobalamin, the myelin sheath does not form properly or stay healthy. As
a result, nerve transmission suffers, and people experience
irreversible nerve damage. Methylcobalamin acts differently than other vitamins.
An intrinsic factor (made in the stomach), that must be present in the intestinal
 tract in significant amounts to allow for its absorption, combines with the
Vitamin B12 that is released from food during digestion. People lacking this
intrinsic factor eventually show symptoms of a Vitamin B12 deficiency - a
condition called Pernicious Anemia. It is a slow and insidious process that can
ultimately end in death. Pernicious (anemia) in fact means, "Leading to death."

Pharmacodynamic Absorption: Vitamin B12 gets bind to intrinsic factor (IF) and form a complex.
This IF-B12 complex is then absorbed in distal ileum. This absorption is done by
a very specific receptor Peak plasma concentrations after 3 hr (oral); 0.9 hr
(IM); 3 min (IV).
Distribution:
Vitamin B12 is distributed to different cells of the body upon binding to
transcobalamin II. It is stored in the liver in amount of 300-500 μg.
Elimination: in urine