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Brodmann area 4 refers to the primary motor cortex of the human brain.

It is located in the posterior


portion of the frontal lobe.

Brodmann area 4 is part of the precentral gyrus. The borders of this area are: the precentral sulcus in
front (anteriorly), the medial longitudinal fissure at the top (medially), the central sulcus in back
(posteriorly), and the lateral sulcus along the bottom (laterally).

This area of cortex, as shown by Wilder Penfield and others, has the pattern of a homunculus. That is,
the legs and trunk fold over the midline; the arms and hands are along the middle of the area shown
here; and the face is near the bottom of the figure. Because Brodmann area 4 is in the same general
location as primary motor cortex, the homunculus here is called the motor homunculus.

The term area 4 of Brodmann-1909 refers to a cytoarchitecturally defined portion of the frontal lobe of
the guenon. It is located predominantly in the precentral gyrus. Brodmann-1909 regarded it as
topographically and cytoarchitecturally homologous to the human gigantopyramidal area 4 and noted
that it occupies a much greater fraction of the frontal lobe in the monkey than in the human. Distinctive
features (Brodmann-1905): the cortex is unusually thick; the layers are not distinct; the cells are
relatively sparsely distributed; giant pyramidal (Betz) cells are present in the internal pyramidal layer (V);
lack of an internal granular layer (IV) such that the boundary between the external pyramidal layer (III)
and the internal pyramidal layer (V) is indistinct; lack of a distinct external granular layer (II); a gradual
transition from the multiform layer (VI) to the subcortical white matter.[1]

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