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Myasthenic Crisis Cholinergic Crisis

•Myasthenic crisis: •Cholinergic crisis:

•an exacerbation of the myasthenic symptoms •an acute exacerbation of muscle weakness caused
caused by undermedication with by overmedication with cholinergic
anticholinesterases anticholinesterase drugs
–Priority for nursing management is to –Muscle twitching to the point of
maintain adequate respiratory function. respiratory compromise
–Cholinesterase inhibiting drugs ineffective –Priority to maintain respiratory function
during crisis and cause increase in –Symptoms improve with anticholinergic
secretions medications (atropine)

Myasthenic Emergency Crisis: Cholinergic Emergency Crisis

* you have to hold the meds (increase secretions) •Anticholinergic drugs are withheld while the client
* Need to remove the secretions. is maintained on a ventilator.
* Maintain respiratory function.
•Atropine may be given and repeated, if necessary.
Dries you up.
•Tensilon test is performed. (will help improve
muscle tone) •Observe for thickened secretions due to the drugs.
•Improvement is usually rapid after appropriate
Cholinesterase-inhibiting drugs are withheld drugs have been given.
because they increase respiratory secretions and -can’t cough
are usually ineffective for the first few days after
the crisis begins.

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