Report on 25th Trendy’s in Biochemistry Meeting at

University of Hyderabad, Telangana on 18th

January 2019.
Inauguration, Convener – Welcome Note by Prof. T. Ramasarma/Prof.K.Subha Rao (About
TRendys in Biochemistry)
10.15 - 10.45 AM Coffee Break
1. Prof.S.Chakrabarthi – Alzheimer’s Disease : Looking beyond protein misfolding.
 AD is common cause of dementia in elderly people caused by distinctive plaques and
neurofibrillary tangles.
 Types- 1) Familial (<5%) – Mutation in PS1 and PS2 genes 2) Sporadic (>95%)
 Pathogenesis: - Pathologically FAD &sporadic AD are very similar -Amyloid cascade
which are dominant hypothesis that explains AD Pathogenesis from over production
accumulation & oligomerization of Amyloidβ(Aβ)42 peptide, both in Familial AD (FAD) &
sporadic AD.
Aβ(monomer)↔smalloligomers↔largeoligomers↔protofibris↔Amyloidfibris↔cros
sβ sheet structure.
2. Prof.Podile Appa Rao – Transglycosylation by bacterial Chitinases.
 -To eliminate pathogens through a biological approach -Transglycosylation by Spchi D -
Residues targeted for mutation a) Catalytic interaction b) Catalytic groove.
3. Prof. T. Rama Sarma – Electron Tranfer in Proteins – a Commentary.
 -Electron coupling mediated by hydrogen bonds, (Hydrogen bond acts as bridge like) -
Hydrogen bond linked pathways of peptide units & polar groups of amino acids residues
suitable for electron transferrin Cytochrome- C proteins. -Binuclear reaction center.
4. Prof. V. Prakash – Chemistry the epicenter of scientific understanding of Life Sciences.
 Exploding cucumbers inspire drug delivery.
 Artificial hips glide on graphite.
 Endocrine disruption wide spread.
 Recognizing coeliac disease (allergic).
 Hybrid compound can kill cancer cells Banana leaf (By Hot foods , leaf colour changes to
brown)
 Vitamin D from sunlight.
 Ghee from butter.
5. Prof. S. Nagini – More than one way to die: The molecular mechanisms of cell death.
 Cell death is an inevitable consequence of life -NCCD(Nomenclature Committee on Cell
Death) Regulated cell death(RCD)-programed cell death(PCD),intra or extracellular
perturbations (stress RCD) 1)Necroptis 2)Ferroptosis 3)Pyroptosis 4)Parthanatos
5)Entosis 6)Anoikis 7)Netotic cell death 8)Lysosome dependent cell death 9)Autophagy
dependent cell death 10)Immunogenic cell death.
6. Prof. Harish Padh – Human Genome to India Genome.
  Disease heterogeneity.
 Genetic Polymorphism
 Omiprazole- ulcer drug
 Herceptene. Monoclonal – Drug for breast cancer
 SNP + INDEL +CNV
 Multi Loci
7. Prof .A.J.Rao –

3.30 – 4.00 PM Coffee Break

8. Prof. V. Sritaramam – Is Mendel’s Gardner gone missing in plant research these days?

 Consumption of substrates activate Growth -Alternative oxidase is more osmotolerant

than cyanide sensitive -Monogeny merogeny (production of unisexual broods)

9. Dr. Debasis Barik – Mathematical modeling in system biology.