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WEBWISE SCORSA: A CDepartment Air Force Phase II SBIR F071-084- FA8750-08June 10, 2 June 10, 2
Thornton ToMetamateri Department
Navy Phase I SBIR N082-191-N00014-09October 27February 0
Thornton ToNovel MethDepartment
Defense ThPhase II SBIR T071-011- HDTRA2-09October 02October 01
Thornton ToUser ToolkiDepartment
Navy Phase I SBIR N081-063-N00014-08May 12, 2 March 12,
Thornton ToPiezoelectrDepartment
Navy Phase II SBIR N071-076-N00014-08SeptemberFebruary 0
WELKIN SCReference Department Navy Phase I SBIR N081-068-N00014-08May 12, 2 March 12,
Thornton ToEngineerinDepartment
Defense ThPhase I SBIR T081-006- HDTRA1-08April 16, 2 October 15
WELKIN SCInterceptoDepartment Missile De Phase II SBIR B063-005-HQ0147-08June 27, 2 March 11,
WESTERN D Secure TCPDepartment
Navy Phase II SBIR F051-093- N00039-08February 2February 2
Wedeven As High PowerDepartment
Army Phase II SBIR A062-077-W911QX-08 SeptemberSeptember
Western EnBioluminesDepartmentNavy Phase I SBIR N082-193-N00014-09October 27October 29
Western EnSurfzone WDepartmentNavy Phase II SBIR N071-079-N00014-08SeptemberMarch 15,
WILLIAMSRMiniature Department Special O Phase II SBIR S062-015- H92222-08January 29January 29
WINCOM LInterdomaiDepartment Air Force Phase I SBIR F081-019- FA8750-08April 25, 2 April 25, 2
Wintec, IncModeling DepartmentNavy Phase II SBIR N071-009-N68335-08June 04, 2 June 04, 2
WIRELESS A Thin Fil DepartmentNavy Phase I SBIR N081-004-N68335-08May 12, 2 November
WIRELESS Digital Be DepartmentAir Force Phase I SBIR F073-073- FA8718-08March 21, December
WIREROPEAdvanced Ca Department
Navy Phase I SBIR N082-136-N68335-09October 16April 16, 2
WETSTONENeural ANO Department
Army Phase I STTR O08A-001-W911NF-08 SeptemberMarch 18,
William P. Highly ReliDepartment
Air Force Phase I SBIR F081-066- FA9300-08August 05,May 08, 2
WILLIAMSRWireless FiDepartmentAir Force Phase I SBIR F073-130- FA9200-08March 03, December
WILLIAMSRUltra Low- DepartmentDefense MiPhase I SBIR 08-8B3 H94003-08February 0August 05,
WILLIAMSRDevelop plu Department
Army Phase II SBIR O071-ES7-W909MY-09 NovemberNovember
WILLIAMSRAcoustic DeDepartmentArmy Phase I SBIR A082-113-W912HZ-09 October 20April 23, 2
WIZDOM SY Architectu Department
Air Force Phase I SBIR F073-016- FA8750-08January 15January 15
Wolf TechniInnovativeDepartment
Air Force Phase I SBIR F081-003- FA8650-08April 25, 2 February 2
XADAIR TEInvestigati Department
Army Phase I SBIR A082-080-W15P7T-09December June 04, 2
X-COM SY Wideband Department
R Air Force Phase II SBIR F071-247- FA8650-08June 23, 2 April 29, 2
XCOR AeroHigh PropeDepartment Air Force Phase I SBIR F081-061- FA9300-08June 21, 2 March 25,
XCOR AeroVariable ThDepartmentAir Force Phase I SBIR O081-PR1-FA9300-08August 08,February 0
Xdot EnginWindage LoDepartmentAir Force Phase I SBIR F081-059- FA8650-08July 10, 20April 10, 2
XENOTRANSoftware DDepartment Army Phase I SBIR A082-108-W15P7T-09December June 22, 2
XCOR AeroHardware CDepartment Air Force Phase II SBIR F071-260- FA8650-08June 17, 2 February 1
XIMAX TECA CompactDepartment Air Force Phase I SBIR F073-111- FA8201-08April 04, 2 January 30
WW TECHNSecurity PoDepartment Missile De Phase I SBIR B073-041-HQ0006-08February 1August 13,
WW TECHNMultiple I Department Air Force Phase II SBIR F071-060- FA8750-08February 2September
WW TECHNTechniquesDepartment Navy Phase II SBIR N061-065-N00024-08SeptemberSeptember
XIOMAS T Real-time Department Navy Phase I SBIR N082-155-N68335-09October 01January 25
XPRT SOLUT Ultra High Department
Navy Phase I SBIR N073-192-N66001-08April 08, 2 November
XPRT SOLUT Modeling aDepartment
Navy Phase II SBIR N071-112-N00039-08SeptemberSeptember
Yankee EnvHandheld RDepartmentAir Force Phase I SBIR F073-110- FA8201-08April 01, 2 January 06
Yankee EnvNext-GenerDepartmentNavy Phase I SBIR N082-195-N00014-09October 27January 28
XPRT SOLUT ReservatioDepartment
Air Force Phase I SBIR F073-020- FA8750-08January 16January 16
Yardney TecThermally SDepartment
Navy Phase I SBIR N081-017-N68335-08May 13, 2 December
Yotta Navi Alternativ Department
National GPhase I SBIR M073-002-HM1582-08 January 28October 28
Yotta Navi Small TeamDepartment
Special O Phase I SBIR S081-001- H92222-08June 09, 2 December
ZAPATA, INUse of EnvDepartmentAir Force Phase II SBIR F061-332- FA8103-08October 03October 03
ZEGER-ABRMultiple C DepartmentNavy Phase I SBIR N081-097-N66001-08July 10, 20May 10, 2
Zatorski C Printing N Department
Army Phase I SBIR A082-068-W911QX-09 October 30January 19
ZEGER-ABRWideband Department
J Navy Phase I SBIR N081-027-N68936-08March 11, April 22, 2
ZEGER-ABRCo-site In DepartmentNavy Phase I SBIR N081-093-N00039-08July 16, 20April 16, 2
Yardney TecAdvanced M Department
Air Force Phase I SBIR O081-EP2-FA8650-08May 21, 2 November
ZEGER-ABRAn AsynchrDepartment Navy Phase I SBIR N082-196-N66001-09December February 1
Yardney TecHigh EnergDepartment
Air Force Phase I SBIR F073-044- FA8650-08January 11January 11
Zel TechnolRemote Det Department
Navy Phase II STTR N064-002-N68335-08April 24, 2 April 24, 2
Yardney TecRadically Department
Air Force Phase II SBIR F071-152- FA8651-08May 30, 2 May 30, 2
ZIVKO AERAir-sea f Department Navy Phase I SBIR N082-190-N00244-08October 16April 16, 2
Zomega TerCompact InDepartmentArmy Phase I SBIR A082-055-W15QKN-0October 31April 30, 2
ZIVA CORPMicro-ActuDepartment Defense AdPhase I SBIR 07SB2-040W31P4Q-08 February 0October 08
Zona TechnA System ADepartmentAir Force Phase I SBIR F081-086- FA8650-08March 28, December
Zona TechnContinuousDepartmentAir Force Phase II STTR F064-016- FA9550-08October 09October 09, 2009
ZYBRON OPContinuousDepartment Air Force Phase II SBIR F061-112- FA8650-08March 01, July 01, 20
ZYBERWEATerahertz Department Army Phase I SBIR A082-075-W911NF-09 NovemberMay 05, 2
AMERICANApplied In Department Army Phase I SBIR A072-096-W15P7T-08January 24July 24, 20
AMERICANSuperior HDepartment Army Phase I SBIR A082-091-W15P7T-09December June 18, 2
American M A Novel EdDepartment
Navy Phase II STTR N074-008-N68335-08SeptemberMarch 11, 2010
AMETHYSTDefect Mapp Department
Missile De Phase I SBIR B073-026-HQ0006-08February 1August 13,
ASPEN AERAerogel AuDepartment Navy Phase I SBIR N082-189-N00014-09October 27November
ASPEN AERDigital Vo DepartmentNavy Phase II SBIR N061-037-N61339-08NovemberNovember
CRITICAL I Advanced SDepartment
Army Phase I SBIR A082-101-W15P7T-09January 05July 05, 20
Defense ElDesign-HarDepartmentAir Force Phase I SBIR F073-094- FA9453-08January 15January 15
DIGITAL OPHolographiDepartmentNavy Phase II SBIR N062-157-N00014-09January 13July 13, 20
Energy Re Real-Time DepartmentAir Force Phase I SBIR F081-041- FA8650-08April 28, 2 April 28, 2
ASPEN PROFlameless PDepartmentArmy Phase II SBIR A072-165-W911QY-08 August 29,March 01,
ANGLE, INCOffboard RDepartmentNavy Phase I SBIR N082-177-N65538-09NovemberJune 02, 2
AMETHYSTPassivationDepartment Missile De Phase II SBIR B063-025-HQ0147-08June 06, 2 June 05, 2
ASPEN PROLow-Temper Department
Army Phase I STTR A08A-009-W911NF-08 July 11, 20July 07, 20
Infoscitex PreventingDepartment
Navy Phase I STTR N08A-011-N68335-08July 14, 20January 14
Infoscitex Low Profil Department
Navy Phase I SBIR N073-163-M67854-08June 24, 2 December
Infoscitex Developmen Department
Army Phase II STTR A074-029-W81XWH-0July 09, 20July 10, 2010
Infoscitex InnovativeDepartment
Navy Phase I STTR N08A-013-N68335-08July 14, 20February 1
Infoscitex Camoufage Department
Army Phase II SBIR A072-155-W81XWH-0NovemberDecember
Infoscitex BiodynamicDepartment
Navy Phase I SBIR N081-031-N68335-08March 30, September
Infoscitex On site steDepartment
Navy Phase I SBIR N073-165-M67854-08April 15, 2 October 15
Infoscitex Aptamers fDepartment
Army Phase I STTR A08A-035-W81XWH-0July 16, 20February 2
Infoscitex BiomoleculDepartment
Air Force Phase I SBIR F073-035- FA8750-08January 17January 17
Infoscitex Commercial Department
Army Phase I SBIR A072-099-W15P7T-08February 1August 19,
Infoscitex AffordableDepartment
Air Force Phase I SBIR F081-016- FA8650-08April 29, 2 February 2
Infoscitex Mobile AirDepartment
Air Force Phase I SBIR F081-005- FA8650-08April 25, 2 February 2
Infoscitex Radiation RDepartment
Air Force Phase I SBIR F073-095- FA9453-08January 18January 19
GeosembleExploiting DepartmentAir Force Phase II STTR F064-004- FA9550-08October 10October 10, 2009
Goleta StarFeature-AidDepartment
Air Force Phase I SBIR F073-069- FA8650-08February 1November
Infoscitex High PerfoDepartment
Missile De Phase I SBIR B073-011-W9113M-0February 1August 12,
Infoscitex Rapid Isol Department
Air Force Phase II
Infoscitex LightweightDepartment
Navy Phase II
Goleta StarW-Band Circ Department
Army Phase I
GRIFFIN T PREdictingDepartment Army Phase II
HOOD-IMPMulti-SourDepartment Navy Phase II
Infoscitex Risk Asses Department
Air Force Phase II
Infoscitex Volume-Sen Department
Army Phase II
Infoscitex Multi-FuncDepartmentArmy Phase II
Infoscitex Mechanisms Department
Navy Phase I
Infoscitex MultifunctDepartmentArmy Phase II
Infoscitex BiomimeticDepartmentNavy Phase II
Infoscitex Head orienDepartmentAir Force Phase II
EURASIA GRapid EthnDepartment Navy Phase I
ExcellatronEnergy StorDepartment
Defense AdPhase I
Infoscitex Laser Harde Department
Air Force Phase I
Infoscitex Head Mount Department
Air Force Phase I
WMK TECHN Advanced D epartment
Navy Phase I
WMK TECHN Direct Die Department
Missile De Phase I
PLx Opco IPC-NSAIDs:Department Army Phase II
CONDUCTIV Advances iDepartment
Air Force Phase I
NANODYNAM Developmen Department
Army Phase I
NANODYNAM Advanced H Department
Navy Phase I
NANODYNAM Developmen Department
Army Phase II
TIPD, LLC Integrated DepartmentDefense AdPhase I
PHOTON-X,Nanophoton Department
Air Force Phase I
INTELLIGE Fusion of Department Air Force Phase I
MICROSTRU Universal Department
Defense AdPhase I
INTELLIGE Fast, Reco DepartmentAir Force Phase I
MSNW, LLCElectrodel Department Air Force Phase II
TIPD, LLC Optical LimDepartmentAir Force Phase I
Sage Techno CSAR-X DigiDepartment
Air Force Phase II
SCITEC, INCDebris AssDepartmentMissile De Phase I
INTELLIGE Vibration ADepartmentAir Force Phase I
Coherent LSoftware DDepartment Army Phase I
TECHNOLOG Weld RepairDepartment
Air Force Phase II
MirumToo ApplicationDepartment Army Phase I
TESLA LABO Enhancing Department
Missile De Phase I
VISTA ENGPOSS-Based Department
Missile De Phase I
LIGHTNINGHarvestingDepartment Navy Phase II
TechnoSoftAutomation Department
Navy Phase II
P C KRAUSA NoninvasDepartment Navy Phase II
Global StraAircraft E Department
Navy Phase II
MO-SCI CoLight WeigDepartment Navy Phase II
IROBOT CODC-ATR: DiDepartment Navy Phase II
OMNITEK PNovel Minia Department
Army Phase II
GEOPHEX, A High SpeDepartment Army Phase II
Intelligent An Integra Department
Army Phase II
SBIR F071-045- FA8650-08April 15, 2 May 15, 2
SBIR N071-001-M67854-08July 30, 20July 30, 20
SBIR A072-115-W15P7T-08January 17March 20,
STTR A074-026-W912HZ-08 SeptemberSeptember 10, 2009
SBIR N062-112-N68335-08July 02, 20June 30, 2
SBIR O063-H07-FA8650-08June 24, 2 June 24, 2
SBIR O063-H02-W81XWH-0May 23, 2 May 23, 2
SBIR O053-A09-W31P4Q-08 May 06, 2 May 10, 2
SBIR N081-012-N68335-08March 27, August 23,
SBIR A062-082-W911QX-08 August 15,August 14,
SBIR N071-074-N00014-08SeptemberSeptember
SBIR F071-020- FA8650-08March 20, April 20, 2
SBIR O081-CR3-N00014-08SeptemberMarch 15,
SBIR 07SB2-058W31P4Q-08 May 06, 2 January 05
SBIR F081-092- FA9453-08June 09, 2 May 09, 2
SBIR F081-011- FA8650-08April 28, 2 February 2
SBIR N073-206-N65538-08March 19, September
SBIR B073-034-W9113M-0April 09, 2 September
SBIR A072-142-W81XWH-0NovemberOctober 24
SBIR F073-037- FA8650-08January 04January 04
SBIR A072-121-W911SR-08January 16July 16, 20
SBIR O081-EP4-N00014-08July 03, 20January 03
SBIR A072-121-W911SR-09December December
SBIR 07SB2-039W31P4Q-08 February 2October 17
STTR F074-007- FA9550-08October 26July 26, 2008
SBIR F081-053- FA8650-08May 22, 2 February 2
SBIR 08SB2-030W31P4Q-09 December August 17,
SBIR F081-055- FA8650-08May 07, 2 February 0
STTR F064-001- FA9550-08NovemberNovember 02, 2009
SBIR F081-008- FA8650-08April 11, 2 February 1
SBIR F071-028- FA8650-08May 29, 2 April 16, 2
SBIR B073-044-W9113M-0February 2August 19,
SBIR F073-135- Fa9101-08April 23, 2 January 23
SBIR A072-089-W15P7T-08April 16, 2 October 31
SBIR F071-135- FA8650-08April 09, 2 August 09,
STTR A08A-001-W91WAW-0 SeptemberMarch 07,
SBIR B073-020-HQ0006-08February 1August 13,
SBIR B073-027-W9113M-0February 1August 13,
STTR N064-026-N00014-08February 1July 31, 20
STTR N064-018-N00014-08February 2November
STTR N064-007-N68335-08February 2March 18,
STTR N064-007-N68335-08May 01, 2 July 15, 20
STTR N074-012-N68335-08SeptemberAugust 15,
STTR N074-024-N00014-09October 31April 30, 2
SBIR A2-2950 W15QKN-0NovemberMarch 02,
SBIR A2-3562 W15QKN-0SeptemberSeptember
SBIR A2-3063 W15P7T-08February 0February 0
Physical ScPortable “ Department Army Phase II SBIR A2-3449 W15QKN-0SeptemberJuly 29, 20
VERDASEE A Compact,Department Army Phase II SBIR A2-3323 W81XWH-0SeptemberJanuary 10
TechnologyModeling EDepartment Army Phase II SBIR A2-3326 W911QY-08 July 29, 20July 29, 20
Eigent TechAutomatedDepartment
I Army Phase II SBIR A2-3252 W81XWH-0NovemberOctober 16
Magnolia Op Design andDepartment Defense AdPhase II SBIR 04SB1-060W31P4Q-09 NovemberFebruary 2
FLUOROCHE Novel PropDepartment Air Force Phase II SBIR O2-0732 FA9300-08SeptemberDecember
Alliance S Light WeighDepartment of DefenPhase II SBIR 06 S1.01-8FA8650-07June 29, 2 April 30, 2
ROBOTIC TEATR: EnerDepartment of DefenPhase II SBIR 87SB1-039N10PC202May 20, 2 May 24, 2
HYPRES, INUltra Low Department of DefenPhase II SBIR A2-3018 W15P7T-08January 16January 16
IROBOT CONostra: Po Department Army Phase II STTR A2-3253 W911NF-08 SeptemberSeptember
DIGITAL FUPassive ImDepartment Army Phase II SBIR A2-3450 W912HZ-09 NovemberApril 30, 2
OMNITEK PMiniaturizeDepartment Army Phase II SBIR A2-3460 W15QKN-1SeptemberSeptember
Prime PhotDifferentiaDepartment Army Phase II SBIR A2-3242 W911W6-0SeptemberJune 30, 2
TDA Researc CO2 Genera DepartmentArmy Phase II SBIR A2-3310 W81XWH-1NovemberNovember
ASSETT, In Velocity S Department Navy Phase II SBIR S051-003- N00024-08February 1October 30
Axon Medic Clinical Ev Department of Healt Phase I SBIR GM0834051R43GM083405-01A1
HARMON B"InteDepartment of AgricuPhase II SBIR 2006-00412
4pi AnalysisImproved Si DepartmenNational I Phase I SBIR 313-08 SB1341-08-SE-0661
ADVR, Inc High Effic DepartmenNational I Phase I SBIR 903-08 SB1341-08-SE-0675
Airborne TeVessel Lau Department of CommPhase I SBIR 08-76 WC133R-08-CN-0136
Applied MaAcoustic P Department of CommPhase I SBIR 08-65 WC133R-08-CN-0144
Boulder NoMWIR SpatiDepartmenNational I Phase I SBIR 402-08 SB1341-08-SE-0663
Circuit Eq High-AccurDepartmenNational I Phase I SBIR 304-08 SB1341-08-SE-0659
Clark & ParClosing an DepartmenNational I Phase I SBIR 205-08 SB1341-08-SE-0656
Droplet MeA miniaturDepartment of CommPhase I SBIR 08-46 WC133R-08-CN-0146
DESERT STSeaTag: DeDepartment of CommPhase II SBIR 07-59 WC133R-08-CN-0168
DISCOVERYLow Noise,DepartmenNational I Phase I SBIR 428-08 SB1341-08-SE-0668
ELECTRONIC AC AmplifiDepartmenNational I Phase I SBIR 102-08 SB1341-08-SE-0680
E L I A LI Extended Re DepartmenNational I Phase I SBIR 912-08 SB1341-08-SE-0683
GENESIC S CVD-basedDepartmenNational I Phase I SBIR 510-08 SB1341-08-SE-0671
Giner, Inc. A MiniatruDepartment of CommPhase I SBIR 08-66 WC133R-08-CN-0139
Green EyesCLASP PhasDepartment of CommPhase II SBIR 07-30 WC133R-08-CN-0169
HEAT, LIG SSP Tool: Department of CommPhase I SBIR 08-3 WC133R-08-CN-0143
High PrecisKilopixel ADepartmenNational I Phase I SBIR 112-08 SB1341-08-SE-0653
Intelligent High Fidel Department of CommPhase I SBIR 08-48 WC133R-08-CN-0141
Kona Blue Refining B Department of CommPhase II SBIR 07-26 WC133R-08-CN-0171
Masscal CoAn ElevateDepartmenNational I Phase I SBIR 504-08 SB1341-08-SE-0670
MESA PHOT High PowerDepartmenNational I Phase I SBIR 310-08 SB1341-08-SE-0660
Michigan ADetecting DepartmenNational I Phase I SBIR 909-08 SB1341-08-SE-0676
Micro Magn Optimized D S epartmenNational I Phase I SBIR 501-08 SB1341-08-SE-0669
NAVSYS COSyncEZ: Ti DepartmenNational I Phase I SBIR 208-08 SB1341-08-SE-0658
Ocean Farm Automation Department of CommPhase II SBIR 07-148 WC133R-08-CN-0164
Ocean Farm Wave Energ Department of CommPhase I SBIR 08-9 WC133R-08-CN-0137
Optical Ph Three AxisDepartmenNational I Phase I SBIR 117-08 SB1341-08-SE-0654
Pettit ApplCarbon Nan Department of CommPhase I SBIR 08-55 WC133R-08-CN-0145
Precision Developmen DepartmenNational I Phase I SBIR 426-08 SB1341-08-SE-0667
PROPAGATILightning PDepartment of CommPhase I SBIR 08-30 WC133R-08-CN-0142
PROSENSINLow-Cost I Department of CommPhase II SBIR 07-88 WC133R-08-CN-0159
REMOTE SEA Novel In Department of CommPhase II SBIR 07-110 WC133R-08-CN-0163
Riverside TA Web-base Department of CommPhase I SBIR 08-16 WC133R-08-CN-0135
SouthwestInnovative DepartmenNational I Phase I SBIR 615-08 SB1341-08-SE-0674
TECHSHOT,High Pres Department of CommPhase I SBIR 08-75 WC133R-08-CN-0140
Srico, Inc. Large AreaDepartmenNational I Phase I SBIR 110-08 SB1341-08-SE-0651
STAR CryoeA MicrocalDepartmenNational I Phase I SBIR 103-08 9.02.1-1.TT
SURVICE EDredged ChDepartment of CommPhase I SBIR 08-22 WC133R-08-CN-0147
SYNKERA TA Novel CODepartment of CommPhase I SBIR 08-15 WC133R-08-CN-0138
Tex Tech InDevelopmen DepartmenNational I Phase I SBIR 611-08 SB1341-08-SE-0673
TRANSLUME Low-Loss, FDepartmenNational I Phase I SBIR 118-08 SB1341-08-SE-0655
Virtual GloRBAC-BaseDepartmenNational I Phase I SBIR 901-08 SB1341-08-SE-0686
VOXTEL, INEfficient DepartmenNational I Phase I SBIR 409-08 SB1341-08-SE-0665
CRITICAL I InnovativeDepartmenNational I Phase I SBIR 605-08 SB1341-08-SE-0672
Aerodyne RA Sensitiv Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0015
AGILTRON,Low Cost I Environmental ProtecPhase I SBIR EP-D-080- EP-D-080-017
EcoArray, IMonitoringEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0026
Avatar AlteAdvance Ma Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0018
Biotex, Inc.Sensitive, Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0024
Chip EnergOutdoor BiEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0025
COMPACT SMmall Scal Environmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-052
EERGC CORControllingEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0027
EIC LABORA Security MEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0028
ELTRON REElectrocheEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0029
ELTRON RELow Cost NEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0030
Entropic SyDecontamin Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0031
Eon Corp. Identifyin Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0032
Expansyn TDevelopmen Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0033
Fitz AeromDevelopmen Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0034
Giner, Inc. Wireless E Environmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-060
Intelligent LSPR Nano-Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0036
Johansson Surface
I PlaEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0037
Kse, Inc. TechnologyEnvironmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-061
Lesktech L Minerals REnvironmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-062
Media andAn InnovatEnvironmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-063
ATS-MER, LA New InnoEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0038
REACTIVE InexpensivEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0041
nGimat Co.Nanomateri Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0046
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M Environmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-065
NANOMATE Highly Bri Environmental ProtecPhase II SBIR EP-D-07-0 EP-D-08-064
National RAutomatedEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0039
QuantLogicA Micro-Var Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0040
TDA Researc Process-in Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0043
Rta Systems A Novel ApEnvironmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0042
the Green Green Produ Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0035
Tok WeldinImproving Environmental ProtecPhase I SBIR EP-D-08-0 EP-D-08-0044
Environmen A New InnoEnvironmental ProtecPhase I SBIR B07A1-001EPD08038 March 01, August 31,
EcoArray, IMonitoringEnvironmental ProtecPhase I SBIR B07B1-003EPD08026 March 01, August 31,
Epicentre LSPR Nano-Environmental ProtecPhase I SBIR B07B1-005EPD08036 March 01, August 31,
the Green Green Produ Environmental ProtecPhase I SBIR B07C1-006EPD08035 March 01, August 31,
ELTRON REElectrocheEnvironmental ProtecPhase I SBIR B07D1-010EPD08029 March 01, August 31,
Biotex, Inc.Sensitive, Environmental ProtecPhase I SBIR B07D1-011EPD08024 March 01, August 31,
Eon Corp. Identifyin Environmental ProtecPhase I SBIR B07E1-012EPD08032 March 01, August 31,
EERGC CORControllingEnvironmental ProtecPhase I SBIR B07F1-017EPD08027 March 01, August 31,
Johansson Surface
I PlaEnvironmental ProtecPhase I SBIR B07F1-017EPD08037 March 01, August 31,
nGimat Co.Nanomateri Environmental ProtecPhase I SBIR B07F1-018EPD08046 March 01, August 31,
AGILTRON,Low Cost I Environmental ProtecPhase I SBIR B07G1-021EPD08017 March 03, August 31,
Aerodyne RA Sensitiv Environmental ProtecPhase I SBIR B07G1-021EPD08015 March 01, August 31,
ELTRON RELow Cost NEnvironmental ProtecPhase I SBIR B07H1-024EPD08030 March 01, August 31,
Expansyn TDevelopmen Environmental ProtecPhase I SBIR B07H1-026EPD08033 March 01, August 31,
TDA Researc Process-In Environmental ProtecPhase I SBIR B07H1-026EPD08043 March 01, August 31,
National RAutomatedEnvironmental ProtecPhase I SBIR B07J1-031EPD08039 March 01, August 31,
Tok WeldinImproving Environmental ProtecPhase I SBIR B07M1-03EPD08044 March 01, August 31,
Chip EnergOutdoor BiEnvironmental ProtecPhase I SBIR B07M1-03EPD08025 March 01, August 31,
REACTIVE InexpensivEnvironmental ProtecPhase I SBIR B07M1-03EPD08041 March 01, August 31,
EIC LABORA Water SecuEnvironmental ProtecPhase I SBIR B07N1-035EPD08028 March 01, August 31,
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Arete AssoAutomatic Department Navy Phase I SBIR N081-044-N65538-08July 08, 20January 20
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Arete AssoCounter-SnDepartment Navy Phase I SBIR N073-164-M67854-08June 19, 2 December
Arete AssoBio-Inspir Department Army Phase I SBIR A082-056-W911QX-09 NovemberMay 09, 2
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Arete AssoExtremely Department Navy Phase II SBIR N072-120-N68335-08SeptemberMarch 31,
Arete AssoMicro-Came Department
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Arete AssoAn Expenda Department
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Arete AssoMagnetic NDepartment Navy Phase II SBIR N071-030-N68335-08July 22, 20July 22, 20
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Vcom3D, InPocket Emai Department of EducaPhase I SBIR H133S080039
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Kitware, InCollaboratiDepartment of EnergPhase I SBIR DE-FG02-08ER85143
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PICARRO, IMethane an Department of EnergPhase II SBIR 83083 DE-FG02-07ER84902
Metrolaser,Optical Te DepartmentAir Force Phase I SBIR F073-052- FA8650-08December September
Metrolaser,Hollow-CorDepartment Air Force Phase I SBIR F073-134- FA9101-08May 14, 2 February 1
Metrolaser,Fatigue CraDepartmentDefense AdPhase I SBIR 07SB2-005W31P4Q-08 February 1October 17
Metrolaser,Integratio DepartmentAir Force Phase I SBIR F073-117- FA8501-08January 22October 21
Metrolaser,Adaptive ODepartment Air Force Phase I SBIR F073-002- FA9451-08January 18January 20
Metrolaser,An All ElecNational Aeronautics Phase I SBIR 074247 NNX08CB1January 18July 21, 2008
Metrolaser,Hydroxyl TNational Aeronautics Phase I STTR 070025 NNX08CD5January 25January 23, 2009
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Metrolaser,Adaptive TDepartment Army Phase II STTR A074-019-W911NF-08 SeptemberSeptember 05, 2009
Metrolaser,A Glass-CeDepartment Air Force Phase II SBIR F071-138- FA8650-08March 24, July 24, 20
Metrolaser,A StereoscoDepartmentAir Force Phase II SBIR F061-300- FA9101-08June 02, 2 June 02, 2
Metrolaser,A Galvo MiDepartment Air Force Phase II SBIR F071-338- FA9201-08SeptemberSeptember
Metrolaser,High ResolDepartment Navy Phase II SBIR N072-118-N68335-09NovemberNovember
Metrolaser,An InstrumNational Aeronautics Phase II SBIR 065634 NNX08CA2December December 17, 2009
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Advanced FTechnologyDepartment of EducaPhase II SBIR ED-07-CO-ED-07-CO-0037
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Advanced Pr In-Soil Ha Department of AgricuPhase I SBIR 2007-00352007-33610-17934
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AGRI PROCE Diversion Department of AgricuPhase I SBIR 2009-01102007-33610-17962
Agri-Starts,MicroponicDepartment of AgricuPhase I SBIR 2007-00112007-33610-17963
AnthrotroniMulti-Moda Department of EducaPhase I SBIR H133S070 H133S070050
APPLIED F Species IdeDepartment of AgricuPhase I SBIR 2007-00482007-33610-17942
AQUACULTU Improving DS epartment of AgricuPhase II SBIR 2003-00502007-33610-18427
AQUAMOST, A PhotoeleDepartment of AgricuPhase I SBIR 2007-00402007-33610-18003
Arcadia BioImproving D R epartment of AgricuPhase I SBIR 2007-00162007-33610-17955
CommunityYouth Map:Department of EducaPhase I SBIR ED-07-CO-ED-07-CO-0046
CommunityA softwareDepartment of EducaPhase II SBIR ED-07-CO-ED-07-CO-0046
AtmospheriDecontamin Department of AgricuPhase I SBIR 2007-00132007-33610-18032
BAXTER LAImproving Department of AgricuPhase I SBIR 2007-00402007-33610-17976
BEE ALERTSONOGRAPH Department of AgricuPhase I SBIR 2009-01132007-33610-17968
Bee Power,Associatio Department of AgricuPhase I SBIR 2007-00302007-33610-18024
BinTech, L Early DetecDepartment of AgricuPhase II SBIR 2004-00112007-33610-18616
BIOLINK LISoluble FerDepartment of AgricuPhase I SBIR 2007-00282007-33610-17946
BIOPROCESAn Integra Department of AgricuPhase II SBIR 2006-00282007-33610-18548
BIOPULPINA novel pr Department of AgricuPhase I SBIR 2007-00322007-33610-17930
BiostratagiPlant-basedDepartment of AgricuPhase I SBIR 2007-00172007-33610-17978
BIOTRONICEnhancing Department of AgricuPhase II SBIR 2006-00152007-02402
BLUE SKY Accessible Department of EducaPhase I SBIR H133S070 H133S070021
Central SigAn InnovatiDepartment of AgricuPhase II SBIR 2006-00352007-33610-18611
Ceramem CAn Integra Department of AgricuPhase II SBIR 2006-00482007-33610-18634
Ceramem CFouling-ReDepartment of AgricuPhase I SBIR 2007-00292007-33610-17944
Children's Developmen Department of EducaPhase II SBIR ED-07-CO-ED-07-CO-0039
COMMGRAPH Children&#Department of AgricuPhase I SBIR 2009-01142007-33610-17969
COMPACT EMnhanced PDepartment of AgricuPhase II SBIR 2006-00472007-33610-18553
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CREATEABIL Hearing CoDepartment of EducaPhase I SBIR H133S080075
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Dancing DoLow VisionDepartment of EducaPhase II SBIR H133S070 H133S070089
Danimer Sci Creation o Department of AgricuPhase II SBIR 2006-00092007-33610-18627
Dantec Engi TechnologyDepartment of AgricuPhase II SBIR 2006-00372007-33610-18617
Soil and T Indirect EsDepartment of AgricuPhase I SBIR 2007-00372007-33610-17927
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EERGC CORUse of CowDepartment of AgricuPhase I SBIR 2007-00092007-33610-18008
Ekips TechnLow Cost, Department of AgricuPhase I SBIR 2007-00092007-33610-17980
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INBIOS INTRapid Immu Department of AgricuPhase II SBIR
Industry V AutomatedDepartment of AgricuPhase II SBIR
INHIBITROLIncreasing Department of AgricuPhase I SBIR
HARRISVACAutogenous Department of AgricuPhase I SBIR
Innovative Performance Department of AgricuPhase I SBIR
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MEMBRANE A Novel, L Department of AgricuPhase I SBIR
Microanalyt Improved, Department of AgricuPhase II SBIR
MONTANABuhl M IdahoDepartment of AgricuPhase I SBIR
MOLECULAR Selection Department of AgricuPhase II SBIR
MolySym, I ntelligen Department of EducaPhase I SBIR
MolySym, I ntelligen Department of EducaPhase II SBIR
MOOK SEACost Effec Department of AgricuPhase I SBIR
MOTION CO Wireless Department of EducaPhase II SBIR
Multiform A New Conc Department of AgricuPhase II SBIR
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LIG SCIENCBiocide EnDepartment of AgricuPhase I SBIR
NexTech Mat Bio-EthanoDepartment of AgricuPhase I SBIR
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NutraceuticLow Cost PrDepartment of AgricuPhase I SBIR 2009-01152007-33610-18014
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PHENOTYPPoplar RooDepartment of AgricuPhase II SBIR 2006-00022007-33610-18517
Polestar TeInexpensivDepartment of AgricuPhase I SBIR 2007-00142007-33610-18019
POLYHEDRO Virtual PhyDepartment of EducaPhase II SBIR ED-07-CO-ED-07-CO-0040
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PORTASCIEAn In-Line Department of AgricuPhase II SBIR 2006-00112007-33610-18447
PROVE IT, A Process fDepartment of AgricuPhase I SBIR 2007-00272007-33610-17999
RAPID BIOLow-cost cDepartment of AgricuPhase I SBIR 2007-00052007-33610-17933
TDA Researc Process FoDepartment of AgricuPhase I SBIR 2007-00072007-33610-18016
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S.A.F.E R& ControllingDepartment of AgricuPhase II SBIR 2006-00532007-33610-18590
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SENSOR D A New Nano Department of AgricuPhase I SBIR 2009-01152007-33610-17972
Seward IncThe First 4Department of EducaPhase I SBIR ED-07-CO-ED-07-CO-0043
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smartenergHeating UsDepartment of AgricuPhase I SBIR 2007-00222007-33610-17932
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SONTEK/YSAgricultur Department of AgricuPhase I SBIR 2007-00362007-33610-18015
Southeaster Mechanized Department of AgricuPhase II SBIR 2006-00032007-33610-18416
Spectrum EDevelopingDepartment of EducaPhase I SBIR ED-07-CO-ED-07-CO-0045
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SPIRIT LAKTribal Lea Department of AgricuPhase I SBIR 2007-00232007-33610-17986
Staron, LLCComparison Department of AgricuPhase I SBIR 2007-00422007-33610-17996
SUMMERDAL Safer, Non Department of AgricuPhase I SBIR 2007-00472007-33610-17989
System SciAn AnalysiDepartment of AgricuPhase II SBIR 2006-00402007-33610-18532
T/J TechnolPolymer ElDepartment of AgricuPhase II SBIR 2006-00372007-33610-18543
Tactus Tec Tactus ImmDepartment of EducaPhase II SBIR ED-07-CO-ED-07-CO-0038
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TERRENEW,The Use ofDepartment of AgricuPhase I SBIR 2007-00182007-33610-17994
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Seahawk BiHandheld BDepartment of HomelPhase II SBIR
SECURICS, FASST MultDepartment of HomelPhase I SBIR
STRUCTURE Radiation Department of HomelPhase I SBIR
SONALYSTS, Botnet DetDepartment of HomelPhase II SBIR
SYNKERA TNanorod ArDepartment of HomelPhase I SBIR
Techno-Scie Constructi Department of HomelPhase I SBIR
TOYON RE Secure andDepartment of HomelPhase I SBIR
TransTech Developmen Department of HomelPhase II SBIR
TRIDENT RRealtime GDepartment of HomelPhase I SBIR
Triton Syst EMI Plasti Department of HomelPhase I SBIR
Trojan Def Low PowerDepartment of HomelPhase I SBIR
UTOPIACOSecond Gen Department of HomelPhase I SBIR
WILLIAMSRWireless, Department of HomelPhase I SBIR
ZonTrak IncSmart-TaggDepartment of HomelPhase I SBIR
Energy Re Standoff DDepartment of HomelPhase I SBIR
Infoscitex Tamper ResDepartment of HomelPhase I SBIR
ABIOMED, A Novel PolDepartment of Healt Phase II SBIR
ABIOMED, BIOACTIVEDepartment of Healt Phase I SBIR
ABLELINK WayFinder:Department of Healt Phase I SBIR
ABQMR, INCompact, lDepartment of Healt Phase I STTR
ACADEMICPressure uDepartment of Healt Phase II SBIR
Accacia IntSBIR PHASDepartment of Healt Phase I SBIR
Accacia IntT7 RNA polDepartment of Healt Phase II STTR
ACCESSIBLEDevelopmen Department of Healt Phase I SBIR
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ACES-RESESynthesis Department of Healt Phase I STTR
ACOUSTX ManufacturDepartment of Healt Phase I SBIR
ACUCELA, Identifyin Department of Healt Phase I SBIR
ACUCELA, In Vitro As Department of Healt Phase I SBIR
Aculight C High resoluDepartment of Healt Phase II STTR
Acumen, LCreating MDepartment of Healt Phase I STTR
Acumen, LCreating R Department of Healt Phase I STTR
ADA Techno Conjugation Department of Healt Phase I SBIR
ADA Techno Novel 3-di Department of Healt Phase I SBIR
ADA Techno SBIR PHASDepartment of Healt Phase I SBIR
ADA Techno A Child&#0Department of Healt Phase II SBIR
ADENOSINE AdenosineDepartment of Healt Phase I SBIR
ADVANCEDA Novel Met Department of Healt Phase I SBIR
Innovative Small Molec Department of Healt Phase I SBIR
ADVANCEDThe Neuroco Department of Healt Phase I SBIR
ADVANCEDSleep ApneDepartment of Healt Phase II SBIR
ADVANCEDNovel non-Department of Healt Phase I SBIR
ADVANCEDLab-on-a-cDepartment of Healt Phase I SBIR
ADVANCEDRegulatoryDepartment of Healt Phase II SBIR
ADVANCEDNext GenerDepartment of Healt Phase I SBIR
ADVANCEDPortable E Department of Healt Phase I SBIR
ADVANCEDHome Pediat Department of Healt Phase I SBIR
ADVANCEDUsing an I Department of Healt Phase I SBIR
ADVANCEDA Wirelss Department of Healt Phase II SBIR
ADVANCEDNovel Syst Department of Healt Phase II SBIR
ADVANCEDIndoor MagDepartment of Healt Phase II SBIR
ADVANCEDAmbulatoryDepartment of Healt Phase II SBIR
A&G PHARM Novel TargDepartment of Healt Phase I SBIR
20/20 GENProfiling Department of Healt Phase I SBIR
20/20 GENPeptide ArrDepartment of Healt Phase I SBIR
Advanced M Cerebral P Department of Healt Phase I SBIR
ADVANSTA,SBIR PHASDepartment of Healt Phase I SBIR
ADVANTAGE Improved sDepartment of Healt Phase I SBIR
ADVANTAGE Clinical an Department of Healt Phase I SBIR
ADVANTAGE Clinical st Department of Healt Phase II SBIR
Aerodyne RBreath AnaDepartment of Healt Phase II SBIR
AEROPHASE Lung Drug Department of Healt Phase II SBIR
AEROPHASE Low Cost PDepartment of Healt Phase I SBIR
AESTUS THAccelerateDepartment of Healt Phase I SBIR
AFASCI, IN Developmen Department of Healt Phase I STTR
AFASCI, IN AutomatedDepartment of Healt Phase I SBIR
AFFINERGY,Interfacial Department of Healt Phase I SBIR
AFFINERGY,Point of CaDepartment of Healt Phase I SBIR
AFFINERGY,Bioactive PDepartment of Healt Phase I SBIR
AFFINERGY,Point of CaDepartment of Healt Phase I SBIR
AFrame DigiNon-intrusiDepartment of Healt Phase I SBIR
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AGENNIX, ITreatment Department
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Internatio Molecular Department of Healt Phase II SBIR
AGENTSHEE Mr. Vetro: Department of Healt Phase II SBIR
AGINOVA, NetworkedDepartment of Healt Phase I SBIR
AGORANET,Personaliz Department of Healt Phase II STTR
Aguila TechStudy of C Department of Healt Phase II STTR
AIKO BIOT Novel neutrDepartment of Healt Phase I SBIR
AKAZA RESOpenClinicDepartment of Healt Phase II SBIR
AKINA, INCDelayed HyDepartment of Healt Phase I SBIR
AKONNI BIDiagnostic Department of Healt Phase I SBIR
AKONNI BIIntegrated Department of Healt Phase I SBIR
ALA SCIENTA Scalable Department of Healt Phase I SBIR
Radiation MHigh Sensi Department of Healt Phase I SBIR
Radiation MRapid DeteDepartment of Healt Phase I SBIR
Radiation MBright and Department of Healt Phase I SBIR
Radiation MHIGH PERFDepartment of Healt Phase I SBIR
Radiation MDiffused ODepartment of Healt Phase I STTR
Radiation MInstrumentDepartment of Healt Phase I SBIR
Radiation MHigh-PerfoDepartment of Healt Phase I SBIR
Radiation MSolid-Stat Department of Healt Phase I SBIR
Radiation MHigh-SpeedDepartment of Healt Phase II SBIR
Radiation MHIGH RESODepartment of Healt Phase II SBIR
Radiation MHigh ResolDepartment of Healt Phase II SBIR
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ALLELE BI SBIR PHASDepartment of Healt Phase I SBIR
Allied InnoUltrasoundDepartment of Healt Phase II SBIR
Allied InnoQuantitativDepartment of Healt Phase II SBIR
ALLTRANZ,Transderma Department of Healt Phase I STTR
ALLVIVO VAPeptide BaDepartment of Healt Phase II SBIR
ALMEN LABComputer-a Department of Healt Phase II SBIR
ALPHAMED, Targeting aDepartment of Healt Phase I STTR
ALPHAMED, ProcessingDepartment of Healt Phase I STTR
AlphaSniffeA Real-TimeDepartment of Healt Phase I SBIR
AMBERGEN, Novel ProtDepartment of Healt Phase II SBIR
AMBERGEN, Mass SpectDepartment of Healt Phase II SBIR
AMBERGEN, A Novel NoDepartment of Healt Phase II SBIR
AMBERGEN, Advanced M Department of Healt Phase II SBIR
AMBION DIIntegrated Department of Healt Phase I SBIR
AMBION DIMultiplex Department of Healt Phase I SBIR
American BImproving D c epartment of Healt Phase I STTR
AMES TECHEMG BiofeDepartment of Healt Phase I SBIR
ANATRACE,Novel Memb Department of Healt Phase I SBIR
AMRON CORandom HaDepartment of Healt Phase I SBIR
AMULET PH Treatment Department
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APC BIOTEDevelopmen Department of Healt Phase I SBIR GM0819451R43GM081945-01
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APELIOTUSTopical TreDepartment of Healt Phase I STTR AR055022 1R41AR055022-01
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APOIMMUN ApoVax104- Department of Healt Phase I SBIR AI071618 1R43AI071618-01A1
APOLLO SRIImproving Department of Healt Phase I STTR CA126155 1R41CA126155-01A1
APPALACHIDigitally Department of Healt Phase II SBIR GM0711832R44GM071183-02
APPLIED MCommercial Department of Healt Phase I SBIR GM0789181R43GM078918-01A1
APPLIED MCommerciali Department of Healt Phase II SBIR HL079783 2R44HL079783-02A1
APPLIED MCommercial Department of Healt Phase II SBIR GM0666152R44GM066615-02
APPLIED S Gridless S Department of Healt Phase II SBIR HL078045 9R44RR024300-02A1
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ARCHIE MDAn Interac Department of Healt Phase I STTR HL087488 1R41HL087488-01A1
ARCHIE MDSIMULATIODepartment of Healt Phase I SBIR DA061121N44DA61121
Archimage,Computer-b Department of Healt Phase II SBIR DK066724 4U44DK066724-03
ARCHIVEX,Long Term Department of Healt Phase II SBIR GM0777682R44GM077768-02
ARIADNE GA Toxicolo Department of Healt Phase I SBIR RR023371 1R43RR023371-01
ARIDIS PH Human Monoc Department of Healt Phase I STTR AI072866 1R41AI072866-01A1
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ASH ACCESMethLock vs Department of Healt Phase II SBIR DK071369 4R44DK071369-02
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ASL AnalytiNoninvasivDepartment of Healt Phase I STTR DK077252 1R41DK077252-01
ATERIS TecDevelopmen Department of Healt Phase I SBIR ES016392 1R43ES016392-01
ATHERSYS,Stem Cells Department of Healt Phase II STTR NS055606 2R42NS055606-02A1
ATLANTIC Prolonged Department of Healt Phase I SBIR RR024079 1R43RR024079-01A1
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ATOM SCIEAnalysis o Department of Healt Phase I SBIR AI072841 1R43AI072841-01
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AUREOGENA BacitraciDepartment of Healt Phase I SBIR
Auritec Ph Sustained RDepartment of Healt Phase I SBIR
Auritec Ph Sustained rDepartment of Healt Phase I SBIR
Auritec Ph Sustained Department of Healt Phase II SBIR
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AVID RADI Clinical E Department of Healt Phase I STTR
AVID RADI 18F-FP-DTBDepartment of Healt Phase I SBIR
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AXONA, INCalpain InhDepartment of Healt Phase I SBIR
BACILLIGENImproved BDepartment of Healt Phase I SBIR
BANYAN BIDevelopmen Department of Healt Phase II SBIR
BARRON ASAssessing Department of Healt Phase I SBIR
BARRON ASEarly IdentDepartment of Healt Phase I SBIR
BARRON ASA HandheldDepartment of Healt Phase II SBIR
BARRON ASAn Auto-AdDepartment of Healt Phase I SBIR
BCR DIAGNEngineeredDepartment of Healt Phase I SBIR
Biodetecti In-field DeDepartment of Healt Phase I SBIR
BECS TechnFast Biose Department of Healt Phase II STTR
BEHAVIOR A computer- Department of Healt Phase II SBIR
BEHAVIOR An InterneDepartment of Healt Phase I SBIR
BehavioralHispanic S Department of Healt Phase II SBIR
BEHAVIORA Computer-B Department of Healt Phase I SBIR
BEHAVIORA Computer-B Department of Healt Phase I SBIR
BELLBROOKHTS AssaysDepartment of Healt Phase I SBIR
BELLBROOKA MicrofuDepartment of Healt Phase I SBIR
BELLBROOKArrayed Mic Department of Healt Phase II SBIR
BETASTEMProgenitorDepartment of Healt Phase I STTR
BEXION PHA novel bi Department of Healt Phase I SBIR
BIND BIOSCSBIR TOPI Department of Healt Phase I SBIR
BIO LOGIC A System fDepartment of Healt Phase II SBIR
BioanalyticMovement-R Department of Healt Phase II SBIR
BIOASSAY SBIR TOPI Department of Healt Phase I SBIR
BIOASSAY SBIR TOPI Department of Healt Phase I SBIR
BIOCATALYT Cloning, ovDepartment of Healt Phase I SBIR
BIOELECT DEVELOPME Department of Healt Phase II SBIR
BIOENGINEMRI-GUIDEDepartment of Healt Phase I SBIR
BIOFORTIS,BioscienceDepartment of Healt Phase II STTR
BIOHELIX Pyrophospho Department of Healt Phase I SBIR
BIOHELIX Developmen Department of Healt Phase I SBIR
BIOLINK P Ultrafiltra Department of Healt Phase I SBIR
BIOLOG, INPhenotypeDepartment of Healt Phase II STTR
ELECTROSONon-InvasiDepartment of Healt Phase II SBIR
BIOMEDICAnti-ischem Department of Healt Phase I SBIR
BIOMEDICIntracavit Department of Healt Phase I SBIR
BIO-ANALYT Space-TimeDepartment of Healt Phase I SBIR
BIO-ANALYT GeostatistiDepartment of Healt Phase I SBIR
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BIO-ANALYT AUTOMATED Department of Healt Phase I SBIR PC000061 N43PC00061
BIO-ANALYT Cancer ClusDepartment of Healt Phase II SBIR CA117171 2R44CA117171-02
BIOMEMS,Wireless I Department of Healt Phase II SBIR EY014739 2R44EY014739-02A2
BIONANOMA ContinuousDepartment of Healt Phase I STTR CA128782 1R41CA128782-01
BIOO SCIE EngineeredDepartment of Healt Phase I SBIR AI072858 1R43AI072858-01
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BiopeptideBAIT VACCDepartment of Healt Phase I SBIR AI072810 1R43AI072810-01
BIOPHYSICS GlomerularDepartment of Healt Phase I SBIR DK078404 1R43DK078404-01
BIOPHYSICS Multi-labelDepartment of Healt Phase II SBIR AI063731 2R44AI063731-02
BIOPHYSICS Magnetic rDepartment of Healt Phase II SBIR HL080837 4R44HL080837-02
BIOPOWERDevelopmen Department of Healt Phase I SBIR GM0819641R43GM081964-01
BIOPOWERA novel theDepartment of Healt Phase I SBIR AI072787 1R43AI072787-01A1
BIOPTIGEN,Full Range Department of Healt Phase I SBIR EY018021 1R43EY018021-01
BIOSCALE, Novel ViralDepartment of Healt Phase II SBIR AI067050 2R44AI067050-03
Biosearch TechnologiDepartment of Healt Phase I SBIR GM0777091R43GM077709-01A1
Biosearch AzoreductaDepartment of Healt Phase II SBIR GM0768432R44GM076843-02
BIO-SIGNADigital Wi Department of Healt Phase I SBIR NS057839 1R43NS057839-01
BIOSPEECHUser AdaptDepartment of Healt Phase I STTR DC008712 1R41DC008712-01
BIOSPHEREDevelopmen Department of Healt Phase I SBIR DK074275 1R43DK074275-01A2
Biostatisti Software foDepartment of Healt Phase II SBIR AG0290294R44AG029029-02
Biostatisti Power AnalDepartment of Healt Phase I SBIR DA0227991R44DA022799-01
BIOTECHNIserial rad Department of Healt Phase II SBIR MD0019862R44MD001986-02
BIOTECHPLSUPRAER, H Department of Healt Phase II SBIR HL078281 2R44HL078281-02A1
Biotex, Inc.Rapid MicrDepartment of Healt Phase I SBIR AI066425 1R43AI066425-01A2
Biotex, Inc.FluorescenDepartment of Healt Phase II SBIR DK067754 2R44DK067754-02A2
BIOTIUM, INovel Caspa Department of Healt Phase I SBIR GM0807981R43GM080798-01
BLATZ SCIEMachine LeDepartment of Healt Phase I SBIR EB007148 1R43EB007148-01
The Blinds A Smart TeDepartment of Healt Phase II SBIR EY014487 2R44EY014487-03A2
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Bolder BiotLong ActinDepartment of Healt Phase II SBIR AR051609 2R44AR051609-02A1
BOSTON MLong StrokDepartment of Healt Phase II SBIR EY016295 2R44EY016295-02
BREATHQUA Expired CODepartment of Healt Phase II STTR HL086316 4R42HL086316-02
BRIGHTONAntimicrobDepartment of Healt Phase II SBIR AI063919 2R44AI063919-02A1
C3 JIAN, INTargeted anDepartment of Healt Phase II STTR MD0018312R42MD001831-02
StreamlineBreath Amm Department of Healt Phase I SBIR AG0290861R43AG029086-01A1
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Icagen, IncBiomarkersDepartment of Healt Phase I SBIR ES016395 1R43ES016395-01
Icagen, IncAdherenceDepartment of Healt Phase II SBIR AT004121 2R44AT004121-02
CAMBRIA BNovel TherDepartment of Healt Phase I SBIR NS057849 1R43NS057849-01A1
CAMBRIA BCOMPOUNDS Department of Healt Phase I SBIR NS055601 1R43NS055601-01A2
CAMBRIDGSpectrally Department of Healt Phase I SBIR EB006254 1R44EB006254-01A1
CAMBRIDGCellularly Department of Healt Phase I SBIR CA130026 1R44CA130026-01
CANTIMER,Salivary O Department of Healt Phase I SBIR DE018271 1R43DE018271-01
BRIGHTOUSBIR PHASDepartment of Healt Phase I SBIR PC000055 N43PC00055
BRIGHTOUTITLE: PA Department of Healt Phase I SBIR PC000046 N44PC00046
KARDIA THADULT HUM Department of Healt Phase II STTR HL080888 2R42HL080888-02
Carigent T Long CircuDepartment of Healt Phase I SBIR
CAS MEDICAdult Opti Department of Healt Phase II SBIR
CASCADIA Demonstrati Department of Healt Phase I SBIR
SANERON CHUCBC modu Department of Healt Phase I STTR
Cell & Tiss Commercial Department of Healt Phase I SBIR
CELL PRESELUNGASOL/L Department of Healt Phase I SBIR
CELL PRESEA ResorbabDepartment of Healt Phase I SBIR
CELL PRESEA Novel ApDepartment of Healt Phase I SBIR
CELL SIGN Finding AcDepartment of Healt Phase I SBIR
CELL SIGN SBIR TOPI Department of Healt Phase I SBIR
CELL SIGN PhosphoSitDepartment of Healt Phase II SBIR
CELLASIC MicrofuidiDepartment of Healt Phase II SBIR
Cellecta, I High ThrouDepartment of Healt Phase I SBIR
Cellecta, I FunctionallDepartment of Healt Phase I SBIR
Cellecta, I Algorithm Department of Healt Phase II SBIR
Cellerant TAttenuatioDepartment of Healt Phase I STTR
CELLEX, INAn Affinit Department of Healt Phase I SBIR
CELLEX, INA Reagent D f epartment of Healt Phase I SBIR
CELLULAR Human Embr Department of Healt Phase I SBIR
CENTICE CSpectroscop Department of Healt Phase II SBIR
CENTICE CRapid poinDepartment of Healt Phase II SBIR
TRS CERAMI Micromachi Department of Healt Phase I SBIR
TRS CERAMI Micromachi Department of Healt Phase II SBIR
CENTROSEnovel macro Department of Healt Phase I SBIR
CENTROSEcardiac ne Department of Healt Phase I SBIR
Cell & Tiss New SolutiDepartment of Healt Phase II SBIR
CELL IMAGA New PrepDepartment of Healt Phase II SBIR
CERTICHEM An In VitroDepartment of Healt Phase II SBIR
CharlessonNovel Comb Department of Healt Phase I SBIR
CharlessonNanotechno Department of Healt Phase I SBIR
CharlessonA Novel ThDepartment of Healt Phase II SBIR
CHEMBIO D Rapid Serod Department of Healt Phase I SBIR
Chembionic A RAPID, Department of Healt Phase I SBIR
Chemdiv, IDiscovery Department of Healt Phase I SBIR
CHEMICA TArsenic SelDepartment of Healt Phase I SBIR
CERVIMARK Cervical bi Department of Healt Phase I SBIR
CHI Systems TEACH PH D I epartment of Healt Phase II SBIR
CIENCIA INMicroarrayDepartment of Healt Phase I SBIR
CIENCIA INProtein MiDepartment of Healt Phase I SBIR
CIENCIA INMHC ArrayDepartment of Healt Phase I SBIR
Cleveland BRADIOPROT Department of Healt Phase I SBIR
CLEVELANDNovel Fast Department of Healt Phase I SBIR
CLEVELANDMultivaria Department of Healt Phase I SBIR
CLEVELANDSide-by-si Department of Healt Phase II STTR
CLINICAL TOnline EduDepartment of Healt Phase II SBIR
CLINICAL TMedical StDepartment of Healt Phase I SBIR
CLINICAL TMedical StDepartment of Healt Phase II SBIR
CA130381 1R43CA130381-01
NS045488 2R44NS045488-04A1
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CME DEVELAssessing Department of Healt Phase II STTR
COGNITIVEDevelopmen Department of Healt Phase II SBIR
COGNOSCINovel Inte Department of Healt Phase I STTR
COGNOSCINovel InterDepartment of Healt Phase I STTR
COGNOSCINovel TreaDepartment of Healt Phase I SBIR
COGNOSCINovel TherDepartment of Healt Phase I SBIR
COGNOSCIDevelopmen Department of Healt Phase I SBIR
COGNOSCINovel Thera Department of Healt Phase II SBIR
COHERA ME Design andDepartment of Healt Phase I SBIR
COHERA ME Design andDepartment of Healt Phase I SBIR
LANCELL, LTopical AdjDepartment of Healt Phase I SBIR
COMMUNICA Learn to L Department of Healt Phase I SBIR
COMMUNITY Not avaiabDepartment of Healt Phase I SBIR
COMPACT N Movel PharDepartment of Healt Phase II SBIR
COLUMBUSCommercial Department of Healt Phase II SBIR
COMBINIX,Novel Puera Department of Healt Phase I SBIR
COMMUNITY Not avaiabDepartment of Healt Phase I SBIR
COMPENDIA Developmen Department of Healt Phase I SBIR
COMPREVAL Binaural A Department of Healt Phase II SBIR
CONTEMPO A PERSON Department of Healt Phase I SBIR
CONSULTAN Developmen Department of Healt Phase II SBIR
ContinuumNumerical Department of Healt Phase I SBIR
CONVERSIO Laser Acti Department of Healt Phase II SBIR
Corum Med NoninvasivDepartment of Healt Phase I SBIR
CRANIOTECImproved m Department of Healt Phase I SBIR
CREATV MIStationary Department of Healt Phase I SBIR
CRECare LLInnovativeDepartment of Healt Phase I STTR
Criterion HLifterMate:Department of Healt Phase I SBIR
Culmini IncA PerformaDepartment of Healt Phase I SBIR
CUSTOMKYN Stimulatio Department of Healt Phase I SBIR
CUSTOMKYN Adaptive HiDepartment of Healt Phase I SBIR
CW OPTICS, NoninvasivDepartment of Healt Phase I SBIR
CYKE, INC. AUTISM INDepartment of Healt Phase I SBIR
CYNTELLECT Improved m Department of Healt Phase II SBIR
CYBERLOGIC Ultrasonic Department of Healt Phase I SBIR
Cytex TheraHip Joint Department of Healt Phase I STTR
CYTOCURE,HTS for ag Department of Healt Phase I SBIR
CYTOMETIXDevelopmen Department of Healt Phase I SBIR
CYTORI THAdipose TisDepartment of Healt Phase I SBIR
DAEDALUSApparatus Department of Healt Phase II SBIR
DANYA INTSupportingDepartment of Healt Phase I SBIR
DANYA INTConfict ReDepartment of Healt Phase I SBIR
DANYA INTTrichotill Department of Healt Phase I SBIR
DANYA INTFamily EngDepartment of Healt Phase I SBIR
DANYA INTTOPIC 58-FDepartment of Healt Phase I SBIR
DANYA INTYouth LivinDepartment of Healt Phase II SBIR
DANYA INTINTERNATIDepartment of Healt Phase I SBIR
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DANYA INTINTERNATIDepartment of Healt Phase I SBIR
DATA NUME Analytic MDepartment of Healt Phase II SBIR
DATA NUME SmoothingDepartment of Healt Phase II SBIR
DAWKINS PCFFONE: ADepartment of Healt Phase I SBIR
DAWKINS PLiving WithDepartment of Healt Phase II SBIR
DANYA INTMaking Sma Department of Healt Phase II SBIR
DEKK-TEC, Camptothec Department of Healt Phase I SBIR
DEKK-TEC, SBIR TOPI Department of Healt Phase I SBIR
LIGHTBRIDTranslatin Department of Healt Phase II SBIR
DEMOGRAPH Small AreaDepartment of Healt Phase I SBIR
DENTAL DEA Unified SDepartment of Healt Phase I SBIR
DESCHUTESWeb-basedDepartment of Healt Phase I SBIR
DESCHUTESWeb-BasedDepartment
T of Healt Phase I SBIR
DESIGNMED Designed ADepartment of Healt Phase I STTR
DECISION NEED-PLUS: Department of Healt Phase I SBIR
DIAGNOSTIPreclinical Department of Healt Phase II SBIR
DIFFERENTDifferenti Department of Healt Phase I SBIR
DIFFERENTA Novel TecDepartment of Healt Phase I SBIR
DIMAGI, INARemind: ADepartment of Healt Phase I SBIR
DIMAGI, INSPIMA: SigDepartment of Healt Phase I SBIR
DISCOVER EFC assay tDepartment of Healt Phase I SBIR
DISCOVER Developmen Department of Healt Phase I SBIR
DISCOVERYTargeted TDepartment of Healt Phase I STTR
DISCOVERYTransposonDepartment of Healt Phase II SBIR
DNA SOFTW Database fDepartment of Healt Phase II SBIR
DOSEBUSTE Eradicatio Department of Healt Phase II SBIR
Divergence,FunctionalDepartment of Healt Phase II SBIR
DMetrix, I Liquid Len Department of Healt Phase I SBIR
DNA SOFTW Developmen Department of Healt Phase II SBIR
DOSIMETRIThree DimeDepartment of Healt Phase II SBIR
DOTY SCIEN Double-tunDepartment of Healt Phase I SBIR
DOTY SCIEN AN ULTRA Department of Healt Phase I SBIR
DRAGONFLY Improved SDepartment of Healt Phase I SBIR
DXRAY, INCLow-Dose H Department of Healt Phase I SBIR
DXRAY, INCFast PhotoDepartment of Healt Phase I SBIR
DXRAY, INCA Novel In Department of Healt Phase I SBIR
DYNADX C Dynamical Department of Healt Phase I STTR
EarthGenesEnvironmen Department of Healt Phase I SBIR
Echemics Ultrapreci Department of Healt Phase I SBIR
ECHO MEDIA New QMR- Department of Healt Phase I SBIR
ECI BIOTE Novel MethDepartment of Healt Phase I SBIR
DYNAMIC CTITLE: PL Department of Healt Phase I SBIR
ANDALYZE,Allosteric Department of Healt Phase I STTR
ECI BIOTE Localized DDepartment of Healt Phase I SBIR
EdenspaceProductionDepartment of Healt Phase I SBIR
EDGE BIOSA ChaperonDepartment of Healt Phase I STTR
EDGE ENTER CD VocabulaDepartment of Healt Phase II SBIR
DA071131N43DA71131
GM0768464R44GM076846-02
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AI073096 1R43AI073096-01A1
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HD0540284R44HD054028-02
ELECTRONIC New Method Department of Healt Phase I SBIR
ELECTRONIC NanopatchDepartment of Healt Phase I SBIR
EDVOTEK, Informal BDepartment of Healt Phase II SBIR
EIC LABORA Rapid PestDepartment of Healt Phase I SBIR
EIC LABORA Nanotube D R epartment of Healt Phase I STTR
EIC LABORA SBIR PHASDepartment of Healt Phase I SBIR
ELGAVISH MRI Quantif Department of Healt Phase II STTR
EMERGE ME Novel DataDepartment of Healt Phase II SBIR
EMETAGEN, Antibiotic Department of Healt Phase I SBIR
EMPIRICALContinuousDepartment of Healt Phase I SBIR
EMT ASSOCI Web-basedDepartment of Healt Phase I SBIR
EMT ASSOCI Developmen Department of Healt Phase I SBIR
ENABLEREH Voice GestDepartment of Healt Phase I SBIR
Zenalux BioOptical surDepartment of Healt Phase I STTR
ENDOMEDIPolysacchaDepartment of Healt Phase I SBIR
ENDOMEDIIn Situ Gel Department of Healt Phase I SBIR
ENERGETIQA Water-WiDepartment of Healt Phase II SBIR
ENERGETIQA CompactDepartment of Healt Phase I SBIR
ENERTECHN Detection Department of Healt Phase I SBIR
ELTRON REPortable ADepartment of Healt Phase II SBIR
ELTRON REFormaldehy Department of Healt Phase I SBIR
ELTRON RELow-Cost PDepartment of Healt Phase I SBIR
ENTERTAINDRUGS AND Department of Healt Phase I SBIR
ERYTHROSIT Murine modeDepartment of Healt Phase I SBIR
Ension, IncNot avaiabDepartment of Healt Phase I SBIR
ENGINEERIAPD to Mea Department of Healt Phase II SBIR
EVERGEN BDerivationDepartment of Healt Phase I SBIR
ActiveSite Novel AntiDepartment of Healt Phase I SBIR
EXPERIMEDMultiplexed Department of Healt Phase II SBIR
EXPRESSIONovel Comb Department of Healt Phase I SBIR
EYERX RESStimulationDepartment of Healt Phase II STTR
EPITOME BA standardDepartment of Healt Phase I SBIR
EPITYPE C A lateral f Department of Healt Phase I STTR
EPIVAX, INOptimizatioDepartment of Healt Phase I SBIR
EPIVAX, INEpitope-drDepartment of Healt Phase I SBIR
EXCELLIMSChiral Ion Department of Healt Phase I SBIR
XHALE, INCDetection Department of Healt Phase I SBIR
XHALE, INCA Breath-bDepartment of Healt Phase I SBIR
Luna InnovDevelopmen Department of Healt Phase I SBIR
Luna InnovDevelopmen Department of Healt Phase I SBIR
Luna InnovDelipidatedDepartment of Healt Phase I SBIR
Luna InnovNot avaiabDepartment of Healt Phase I SBIR
FAIRWAY M3D Hybrid Department of Healt Phase I SBIR
FASGEN, INFatty Acid Department of Healt Phase I SBIR
FERMALOGI Industrial Department of Healt Phase I SBIR
FERMALOGI Metabolic Department of Healt Phase I SBIR
FFA SCIENCA FluoresceDepartment of Healt Phase II SBIR
HG0044661R43HG004466-01
EB007100 1R43EB007100-01A1
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GM0767361R43GM076736-01A1
HV000022N43HV00022
HL078055 2R44HL078055-02A1
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DK073535 2R44DK073535-02
FirstString EvaluationDepartment of Healt Phase I SBIR DK080567 1R43DK080567-01
FIREBIRD Dynamic coDepartment of Healt Phase I STTR GM0798971R41GM079897-01
ADARZA BIA Rapid LaDepartment of Healt Phase I SBIR ES016406 1R43ES016406-01
ADARZA BILABEL-FREDepartment of Healt Phase I SBIR CN000042N43CN00042
SEHDA, INCImproving D P epartment of Healt Phase II SBIR NR0100724R44NR010072-02
FluorescenNew ExperiDepartment of Healt Phase I SBIR EB007866 1R43EB007866-01
FLUOROUSFluorous SDepartment of Healt Phase II STTR GM0754362R42GM075436-02
Fluxion BioHigh ThrouDepartment of Healt Phase II SBIR GM0755092R44GM075509-02
FLYING BR Phase II D Department of Healt Phase II SBIR DA0202172R44DA020217-02
FORSYTHE An implantDepartment of Healt Phase I SBIR EY014284 1R43EY014284-01A2
FUNCTIONA Discovery oDepartment of Healt Phase I SBIR AI074484 1R43AI074484-01A1
QUALITY EMiniature Department of Healt Phase I SBIR EB007094 1R43EB007094-01A2
G AND H MA DIAGNOSDepartment of Healt Phase I STTR AG0303001R41AG030300-01
GABRIEL PSBIR TripleDepartment of Healt Phase I SBIR MH0813651R43MH081365-01
Solicita SolicitatTopic CoAward YAward ADUNS HubzoneSocially Woman Number
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2008.1 2008 AF081-0412008 100000 088156708N N N 8
2007.2 2007 A07-165 2008 729993 012925504N N N 10
2008.2 2008 N08-177 2008 69953 N N N 22
2006.3 2006 MDA06-022008 998574 159048698N Y Y 7
2008.A 2008 A08-T009 2008 99996 012925504N N N 10
2008.A 2008 N08-T011 2008 69978 004627316N N N 60
2007.3 2007 N07-163 2008 69992 004627316N N N 60
July 10, 2010 2007 A07-T029 2008 749931 004627316N N N 60
2008.A 2008 N08-T013 2008 69971 004627316N N N 60
2007.2 2007 A07-155 2008 712718 004627316N N N 60
2008.1 2008 N08-031 2008 79982 004627316N N N 60
2007.3 2007 N07-165 2008 69912 004627316N N N 60
2008.A 2008 A08-T035 2008 99995 004627316N N N 60
2007.3 2007 AF073-0352008 99763 004627316N N N 60
2007.2 2007 A07-099 2008 69738 004627316N N N 52
2008.1 2008 AF081C-012008 99992 004627316N N N 60
2008.1 2008 AF081-0052008 99835 004627316N N N 60
2007.3 2007 AF073-0952008 99949 004627316N N N 60
October 10, 2009 2006 AF06-T0042008 742459 175898175N N N 5
2007.3 2007 AF073-0692008 100000 800116324N N N 2
2007.3 2007 MDA07-012008 99961 004627316N N N 60
 2007.1 2007 AF071-0452008 749974 004627316N N N 60
2007.1 2007 N07-001 2008 746105 004627316N N N 60
2007.2 2007 A07-115 2008 120000 800116324N N N 4
September 10, 2009 2007 A07-T026 2008 750000 073688926N N N 2
2006.2 2006 N06-112 2008 749682 787229546N N N 0
2006.3 2006 OSD06-H0 2008 749992 004627316N N N 52
2006.3 2006 OSD06-H0 2008 749972 004627316N N N 60
2005.3 2005 OSD05-A0 2008 749890 004627316N N N 52
2008.1 2008 N08-012 2008 149983 004627316N N N 60
2006.2 2006 A06-082 2008 729986 004627316N N N 60
2007.1 2007 N07-074 2008 450027 004627316N N N 60
2007.1 2007 AF071-0202008 749682 004627316N N N 60
2008.1 2008 OSD08-CR 2008 96000 105448711N N N 78
2007.2 2007 SB072-0412008 98916 038154956N N N 8
2008.1 2008 AF081-0922008 99962 004627316N N N 60
2008.1 2008 AF081-0112008 99975 004627316N N N 60
2007.3 2007 N07-206 2008 69952 809106383N N N 31
2007.3 2007 MDA07-032008 99999 809106383N N N 31
2007.2 2007 A07-142 2008 729992 140243572N N N 6
2007.3 2007 AF073-0372008 99445 150393569Y N N 10
2007.2 2007 A07-121 2008 119997 127760085Y N N 110
2008.1 2008 OSD08-EP42008 99333 787243398N N N 130
2007.2 2007 A07-121 2008 364967 127760085N N N 125
2007.2 2007 SB072-0242008 98873 601990778N N N 1
July 26, 2008 2007 AF07-T0072008 98000 141952098N N Y 6
2008.1 2008 AF081-0532008 99997 097858836N N N 60
2008.2 2008 SB082-0122008 98820 191088892N N N 14
2008.1 2008 AF081-0552008 99983 097858836N N N 60
November 02, 2009 2006 AF06-T0012008 750000 044381445N N N 9
2008.1 2008 AF081-0082008 99990 601990778N N N 4
2007.1 2007 AF071-0282008 2624650 186002226N N N 20
2007.3 2007 MDA07-042008 99939 096845169N N N 40
2007.3 2007 AF073-1352008 99809 097858836N N N 60
2007.2 2007 A07-089 2008 68071 118514855N N N 32
2007.1 2007 AF071-1352008 749728 959735713N N N 225
2008.A 2008 A08-T001 2008 100000 809423762N N N 3
2007.3 2007 MDA07-022008 100000 122900918N Y N 5
2007.3 2007 MDA07-022008 100000 605513048N N N 6
2006. 2006 N06-T026 2008 3091750 156110996N N N 1
2006. 2006 N06-T018 2008 2228240 868140278N N N 16
2006. 2006 N06-T007 2008 2115090 161183322N N N 29
2006. 2006 N06-T007 2008 1586010 608472374N N N 6
2007. 2007 N07-T012 2008 734479 190717025N N N 35
2007. 2007 N07-T024 2008 732217 807380951N N N 455
2006.2 2006 A06-049 2008 2077350 010230287N N N 8
2007.2 2007 A07-169 2008 2993700 148040447N N N 11
2005.2 2005 A05-113 2008 1279160 161911532N N Y 90
2007.2 2007 A07-043 2008 1856690 073800062N N N 150
2007.2 2007 A07-145 2008 1985230 011130023N N N 7
2007.2 2007 A07-159 2008 1550630 140767224N N Y 30
2007.2 2007 A07-144 2008 1379950 148953123N N N 8
2004.1 2004 MDA04-022008 1497060 032691763N Y N 4
2006.3 2006 OSD06-PR 2008 764025 052244290N N N 4
2006.1 2006 06-1-S1.012008 1166930 N N N 200
2087.1 2087 A87-323 2008 923694 N N N 3
2005.2 2005 A05-107 2008 779913 N N N 31
2007.0 2007 A07-T013 2008 769708 000000000N N N 450
2007.2 2007 A07-125 2008 472973 000000000N N N 300
2007.2 2007 A07-035 2008 1229700.9010230287N N N 8
2007.2 2007 A07-011 2008 1800727.1131199445N N N 13
2007.2 2007 A07-152 2008 1445783.8181947730N N N 75
2005.1 2005 SOCOM05-2008 2213991 020910951N N N 38
PHS2007-22008 2008 95768 808354401Y Y Y 0
2008 350000 019089007N N N 1
2008 90000 N N N 0
2008 89974 N N N 0
NOAA-20082008 8.4.3 2008 94969 N N N 4
NOAA-20082008 8.1.9 2008 95000 N N N 7
2008 89709 N N N 0
2008 89995 N N N 0
2008 84480 N N N 0
NOAA-20082008 8.2.2 2008 94987 N N N 29
NOAA-20072007 8.1.3 2008 392039 N N N 10
2008 90000 N N N 0
2008 89974 N N N 0
2008 90000 N N N 0
2008 90000 N N N 0
NOAA-20082008 8.1.9S 2008 94997 066594979N Y N 46
NOAA-20072007 8.1.4 2008 356527 N N N 1
NOAA-20082008 8.1.9 2008 94948 N N N 10
2008 89977 N N N 0
NOAA-20082008 8.1.3 2008 94996 N N N 34
NOAA-20072007 8.1.8 2008 259000 N N N 45
2008 90000 N N N 0
2008 90000 N N N 0
2008 89608 N N N 0
2008 89978 N N N 0
2008 89974 N N N 0
NOAA-20072007 8.1.14 2008 300000 N N N 3
NOAA-20082008 8.1.13 2008 94651 N N N 3
2008 89976 N N N 0
NOAA-20082008 8.1.7 2008 94928 N N N 4
2008 90000 N N N 0
NOAA-20082008 8.4.1 2008 95000 N N N 18
NOAA-20072007 8.3.7 2008 400000 N N N 16
NOAA-20072007 8.3.5 2008 399954 N N N 7
NOAA-20082008 8.2.3 2008 94902 N N N 79
2008 90000 N N N 0
NOAA-20082008 8.1.4 2008 94985 N N N 30
2008 89991 N N N 0
2008 89997 N N N 0
NOAA-20082008 8.4.4 2008 94975 N N Y 180
NOAA-20082008 8.1.9S 2008 95000 N N N 12
2008 87292 N N N 0
2008 89993 N N N 0
2008 82598 N N N 0
2008 90000 N N N 0
2008 89613 N N N 0
2008 70000 N N N 0
2008 69952 N N N 0
2008 69501 N N N 0
2008 70000 N N N 0
2008 69961 N N N 0
2008 70000 N N N 0
2008 225000 808898894N N N 0
2008 70000 N N N 0
2008 70000 N N N 0
2008 70000 N N N 0
2008 70000 N N N 0
2008 70000 N N N 0
2008 70000 N N N 0
2008 69668 N N N 0
2008 66885 N N N 0
2008 224997 066594979N N N 0
2008 69998 N N N 0
2008 70000 N N N 0
2008 225000 025207911N N N 0
2008 224999 189394633N N N 0
2008 225000 802071662N N N 0
2008 70000 N N N 0
2008 69990 N N N 0
2008 69999 N N N 0
2008 225000 946856804N N N 0
2008 224997 030498609N N N 0
2008 70000 N N N 0
2008 69980 N N N 0
2008 70000 N N N 0
2008 69956 N N N 0
2008 69556 N N N 0
2008 70000 N N N 0
PR-NC-07- 2008 07-NCER-A2008 70000 147518286N N N
PR-NC-07- 2008 07-NCER-B2008 69501 153891804N N N
PR-NC-07- 2008 07-NCER-B2008 69998 033449757N N N
PR-NC-07- 2008 07-NCER-C2008 69641 362507886N N N
PR-NC-07- 2008 07-NCER-D2008 70000 029303690N N N
PR-NC-07- 2008 07-NCER-D2008 69960.5 969792050N N N
PR-NC-07- 2008 07-NCER-E2008 70000 783679074N N N
PR-NC-07- 2008 07-NCER-F2008 70000 076922793N N N
PR-NC-07- 2008 07-NCER-F2008 70000 129667585N N N
PR-NC-07- 2008 07-NCER-F2008 69999 806337762N N N
PR-NC-07- 2008 07-NCER-G2008 69951.64 004841644N N N
PR-NC-07- 2008 07-NCER-G2008 70000 030817290N N N
PR-NC-07- 2008 07-NCER-H2008 70000 029303690N N N
PR-NC-07- 2008 07-NCER-H2008 69668 787250351N N N
PR-NC-07- 2008 07-NCER-H2008 70000 181947730N N N
PR-NC-07- 2008 07-NCER-J 2008 70000 107070567N N N
PR-NC-07- 2008 07-NCER- 2008 70000 122815710N N N
PR-NC-07- 2008 07-NCER- 2008 70000 787015148N N N
PR-NC-07- 2008 07-NCER- 2008 69989.73 101061500N N N
PR-NC-07- 2008 07-NCER-N2008 70000 076603836N N N
PR-NC-07- 2008 07-NCER-N2008 70000 796511202N N N
PR-NC-07- 2008 07-NCER-N2008 69956 143049117N N N
PR-NC-07- 2008 07-NCER-P2008 225000 946856804N N N
PR-NC-07- 2008 07-NCER-P2008 224996.77030498609N N N
PR-NC-07- 2008 07-NCER-P2008 224999.2 189394633N N N
PR-NC-07- 2008 07-NCER-P2008 225000 808898894N N N
PR-NC-07- 2008 07-NCER-P2008 225000 025207911N N N
PR-NC-07- 2008 07-NCER-P2008 224997 066594979N Y N
PR-NC-07- 2008 07-NCER-P2008 225000 802071662N Y N
2007.3 2007 AF073-1302008 99996 094142122N N Y 14
2007.3 2007 AF073-1352008 99995 094142122N N Y 14
2007.3 2007 MDA07-042008 99993 094142122N N Y 14
2008.2 2008 N08-115 2008 149941 101719735N N N 5
2007.1 2007 N07-025 2008 749935 101719735N N N 4
2007.2 2007 A07-111 2008 69998 082191198N N N 236
2008.1 2008 AF081-0472008 99986 082191198N N N 275
2008 89888 N N N 0
2008.2 2008 N08-152 2008 79956 082191198N N N 300
2008.1 2008 N08-044 2008 99991 082191198N N N 275
2008.2 2008 N08-138 2008 79995 082191198N N N 305
2008.1 2008 N08-009 2008 79833 082191198N N N 275
2007.3 2007 N07-164 2008 69982 082191198N N N 259
2008.2 2008 A08-056 2008 119892 082191198N N N 308
2008.2 2008 A08-099 2008 69996 082191198N N N 270
2008.2 2008 A08-041 2008 69995 082191198N N N 307
2007.2 2007 SB072-0092008 98994 082191198N N N 236
2007.1 2007 AF071-2362008 749979 082191198N N N 300
2005.2 2005 A05-153 2008 729994 082191198N N N 259
 2007.2 2007 N07-120 2008 999943 082191198N N N 320
2006.1 2006 N06-091 2008 1125000 082191198N N N 280
2007.1 2007 N07-079 2008 737643 082191198N N N 300
2007.1 2007 N07-030 2008 748099 082191198N N N 302
NOAA-20082008 8.4.4 2008 95000 N N N 313
2008 74973 N N N 0
2006.3 2006 OSD06-CR 2008 749617 799834254N N Y 17
2008 500000 N N N 0
NSF 07-551 AM 2008 150000 780418369N N N 1
PHS2007-22008 2008 749421 154870455Y Y Y 0
2007.2 2007 A07-010 2008 904679 N N N 42
DE-PS02-02008 40 a 2008 100000 010926207N N N 51
DE-PS02-02008 16 b 2008 99759 046635632N N N 23
DE-PS02-02007 47 2008 749845 046635632N N N 17
2007.3 2007 AF073-0522008 99967 188465819N N N 23
2007.3 2007 AF073-1342008 99917 188465819N N N 23
2007.2 2007 SB072-0032008 98946 188465819N N N 28
2007.3 2007 AF073-1172008 99936 188465819N N N 23
2007.3 2007 AF073-0022008 99981 188465819N N N 23
July 21, 2008 2007 A2.08 2008 99949 188465819N Y N 23
January 23, 2009 2007 T9.01 2008 100000 188465819N N N 23
December 02, 2010 2007 MDA07-T02008 749943 188465819N N N 24
September 05, 2009 2007 A07-T019 2008 749954 188465819N N N 22
2007.1 2007 AF071-1382008 749988 188465819N N N 23
2006.1 2006 AF06-300 2008 749957 188465819N N N 28
2007.1 2007 AF071-3382008 846619 188465819N N N 24
2007.2 2007 N07-118 2008 749980 188465819N N N 22
December 17, 2009 2006 S4.04 2008 599971 188465819N N N 26
PHS2007-22008 2008 87700 803095178Y Y Y 0
2008.2 2008 N08-149 2008 145798 616284969N N Y 3
2007.1 2007 AF071-0872008 741457 616284969N N Y 3
2008.2 2008 SB082-0252008 98995 786666508N N N 1
PHS2007-22008 2008 383625 167580682Y Y Y 0
2008.1 2008 AF081-0212008 99999 036593457N N N 160
2007.3 2007 AF073-0802008 98329 036593457N N N 145
2006.3 2006 MDA06-002008 1435200 036593457N N N 145
2006.3 2006 MDA06-012008 999998 036593457N N N 145
January 06, 2010 2005 T4.02 2008 600000 036593457N N N 151
2007.3 2007 MDA07-042008 99537 036593457N N N 145
2008.2 2008 A08-039 2008 70000 036593457N N N 154
2008.A 2008 ST081-0042008 98999 036593457N N N 145
2007.3 2007 MDA07-042008 99537 036593457N N N 145
2006.2 2006 A06-112 2008 728647 036593457N N N 150
2008 100000 N N N 0
2005.1 2005 AF05-265 2008 749954 024384633Y Y N 13
2006.1 2006 AF06-330 2008 749957 024384633Y Y N 13
84.133S 2007 2007 74998 Y Y Y 0
84.133S 2007 2007 74998 Y Y Y 0
84.133S 2007 2007 75000 Y Y Y 0
84.133S 2007 2007 75000 Y Y Y 0
errd080002007 2007 749952 021804661N N N 0
84.133S 2007 2007 75000 Y Y Y 0
84.133S 2007 2007 75000 Y Y Y 0
2007 79929 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 79219 N N N 0
2007 64570 N N N 0
84.133S 2007 2007 74982 Y Y Y 0
2007 79737 N N N 0
2007 311018 N N N 0
2007 80000 N N N 0
2007 79914 N N N 0
errd080002007 2007 100000 011115248Y Y Y 0
2007 750000 011115248N N N 0
2007 79999 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 346000 N N N 0
2007 79590 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 79962 N N N 0
2007 346000 N N N 0
84.133S 2007 2007 74997 Y Y Y 0
2007 346000 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
errd080002007 2007 750000 154161660N N N 0
2007 79581 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 199456 N N N 0
2007 75000 N N N 0
2007 346000 N N N 0
84.133S 2007 2007 500000 Y Y Y 0
2007 346000 N N N 0
2007 328085 N N N 0
2007 48959 N N N 0
2007 80000 N N N 0
2007 79988 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
 2007 346000 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 78171 N N N 0
2007 317525 N N N 0
2007 80000 N N N 0
2007 79689 N N N 0
2007 342826 N N N 0
2007 69000 N N N 0
2007 79964 N N N 0
2007 80000 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 79720 N N N 0
2007 80000 N N N 0
84.133S 2007 2007 74990 Y Y Y 0
2007 346000 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 79920 N N N 0
2007 62534 N N N 0
2007 346000 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 25000 N N N 0
2007 346000 N N N 0
84.133S 2007 2007 75000 Y Y Y 0
84.133S 2007 2007 497716 Y Y Y 0
2007 346000 N N N 0
2007 46787 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 346000 N N N 0
2007 79998 N N N 0
2007 346000 N N N 0
2007 79884 N N N 0
2007 346000 N N N 0
errd080002007 2007 99438 143412471Y Y Y 0
2007 745750 143412471N N N 0
2007 80000 N N N 0
84.133S 2007 2007 500000 Y Y Y 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
 2007 346000 N N N 0
2007 80000 N N N 0
84.133S 2007 2007 496159 Y Y Y 0
2007 346000 N N N 0
2007 718878 145944166N N N 0
2007 80000 N N N 0
84.133S 2007 2007 75000 Y Y Y 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 79191 N N N 0
2007 80000 N N N 0
2007 346000 N N N 0
2007 79892 N N N 0
errd080002007 2007 750000 556059728N N Y 0
2007 346000 N N N 0
2007 346000 N N N 0
2007 80000 N N N 0
2007 79941 N N N 0
2007 80000 N N N 0
84.133S 2007 2007 75000 Y Y Y 0
84.133S 2007 2007 74925 Y Y Y 0
2007 80000 N N N 0
2007 79999 N N N 0
2007 346000 N N N 0
2007 499948 116749289N N N 0
2007 346000 N N N 0
2007 76670 N N N 0
errd080002007 2007 100000 927570515Y Y Y 0
2007 750000 927570515N N N 0
2007 79618 N N N 0
2007 80000 N N N 0
2007 80000 N N N 0
2007 79336 N N N 0
2007 346000 N N N 0
errd080002007 2007 100000 129853073Y Y Y 0
2007 749977 129853073N N N 0
2007 79816 N N N 0
2007 79826 N N N 0
2007 45700 N N N 0
2007 346000 N N N 0
2007 346000 N N N 0
2007 750000 102377582N N N 0
2007 80000 N N N 0
2007 79716 N N N 0
84.133S 2007 2007 74793 014447945Y Y Y 0
2007 76300 N N N 0
2007 80000 N N N 0
 2007 79994 N N N 0
2007 720000 136250151N N N 0
2007 79629 N N N 0
2007 80000 N N N 0
2007 79179 N N N 0
2007 79971 N N N 0
2007 80000 N N N 0
2007 150000 836439968N N N 10
H-SB07.1- 2007 99775.42999999999 N N N 72
July 31, 2008 2007 H-SB07.2- 2007 99909 801518747N N N 87
2007 150000 103403523N N N 6
July 03, 2009 2005 H-SB05.2- 2007 749996 606421105N N N 200
2007 98020 N N N 25
2007 149627 021804661N N N 14
May 07, 2008 2007 H-SB07.1- 2007 100000 927303412N N N 8
2007 100000 N N N 55
H-SB05.2- 2007 750000 N N N 4
2007 99606 N N N 4
May 07, 2008 2007 H-SB07.1- 2007 99909 004841644N N N 110
March 24, 2008 2007 H-SB07.1- 2007 150000 957992522N N Y 9
2007 100000 N N N 6
2005 H-SB05.1- 2007 749999 N N N 78
H-SB07.1- 2007 149999 073804411N N N 94
2007 150000 073804411N N N 94
H-SB07.2- 2007 149955.77013475129N N N 40
H-SB06.1- 2007 996973 013475129N N N 30
July 26, 2009 2006 H-SB06.1- 2007 749791 052062833N N N 77
2007 100000 N N N 8
April 24, 2010 2005 H-SB05.2- 2007 749956 197187602N N Y 47
2007 97916 N N N 82
H-SB07.1- 2007 100000 N N N 22
March 19, 2009 2006 H-SB06.1- 2007 749990 N N N 100
March 10, 2010 2006 H-SB06.1- 2007 749996.1 118229819N Y Y 25
H-SB05.2- 2007 750000 N N N 8
2007 148976 074569385N N N 5
2007 99967 N N N 214
June 28, 2008 2007 H-SB07.2- 2007 149868 106540458Y N N 10
2007 149990 101711786N N N 8
2007 99901 N N N 83
2007 100000 N N N 100
H-SB07.2- 2007 99998.09 N N N 103
2007 100000 N N N 103
2007 100000 N N N 103
May 07, 2008 2007 H-SB07.1- 2007 99911 877452664N N N 8
2007 99500 N N N 30
July 14, 2009 2005 H-SB05.2- 2007 744728.0600000001 N N N 4
March 09, 2008 2005 H-SB05.2- 2007 745488 N N N 7
 2007 150000 791029551N N N 3
2007 99990 623594038N N N 5
October 31, 2009 2005 H-SB05.1- 2007 925999.3 184758308N N N 135
2007 100000 N N N 117
2007 100000 N N N 117
H-SB05.1- 2007 953017 N N N 20
September 30, 2010 2006 H-SB06.1- 2007 800000 N N N 14
2007 150000 148828010N N N 4
2007 100000 N N N 2
2007 100000 N N N 2
2007 150000 825520562N N N 0
2007 99998 N N N 4
2007 98688 N N N 33
2007 100000 N N N 130
2007 150000 134291322N N N 18
H-SB05.2- 2007 749988 N N N 198
2007 100000 N N N 229
2007 99996 N N N 229
2007 99996 N N N 229
2007 99996 N N N 229
September 17, 2009 2006 H-SB06.1- 2007 999991.9 788133387N N N 158
2007 99983 N N N 17
2007 100000 N N N 14
June 30, 2009 2005 H-SB05.2- 2007 750000 149335536N N N 2
2007 100000 N N N 6
2007 149999 787144807N N N 16
October 31, 2009 2006 H-SB06.1- 2007 750000 077317766N N N 411
2007 150000 130993384N N N 12
2007 100000 N N N 55
2007 100000 N N N 87
December 30, 2008 2006 H-SB06.1- 2007 999829.4 N N N 44
2007 99309 N N N 9
2007 99982 N N N 62
2007 149998 150716244N N N 2
2007 99999 N N N 15
2007 100000 N N N 94
2007 149978 626133073N N N 5
2007 100000 N N N 6
May 07, 2008 2007 H-SB07.1- 2007 99969 004627316N N N 120
2007 2007 483048 050636737N Y Y 0
PHS 2007- 2007 2007 99312 N N N 0
2007 100000 008546678N N N 0
2007 2007 167183 362518149N Y Y 0
2007 2007 329882 157743451N Y Y 0
PHS 2007- 2007 2007 149944 N N Y 0
2007 2007 672066 084994735N Y Y 0
2007 2007 99992 847286739Y Y Y 0
 2007 2007 223300 784692001Y Y Y 0
2007 2007 99986 141050547N Y Y 0
2007 2007 162281 110352742Y Y Y 0
2007 2007 99295 176412612Y Y Y 0
2007 2007 100000 176412612N Y Y 0
2007 2007 326439 801518747Y Y Y 0
2007 2007 99717 083778964N Y Y 0
2007 2007 99227 083778964N Y Y 0
2007 2007 99933 148034408Y Y Y 0
2007 2007 101824 148034408N Y Y 0
PHS 2007- 2007 2007 145229 148034408N N N 0
2007 2007 451928 148034408N Y Y 0
2007 2007 104783 001016760N Y Y 0
2007 2007 181195 193305252N N Y 0
2007 2007 99097 169174146N Y Y 0
2007 2007 200000 969842715N Y Y 0
2007 2007 566307 969842715N Y Y 0
2007 2007 177040 140320396Y Y Y 0
2007 2007 188364 140695474Y Y Y 0
2007 2007 511733 927303412N Y Y 0
2007 2007 121314 927303412N Y Y 0
2007 2007 100000 927303412N Y Y 0
2007 2007 100029 927303412Y Y Y 0
2007 2007 100000 927303412Y Y Y 0
2007 2007 775674 927303412Y Y Y 0
2007 2007 387218 927303412N Y Y 0
2007 2007 386674 927303412Y Y Y 0
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Company
AddressAddressCity State Zip Contact Contact CTontact Contact
http://wwwBuilding B,5266 Holli Santa BarbCA 93111 Richard A VP, Market(805) 696- kemm@webw
http://ww 375 Hudson St FL 12 New York NY 10014 Susan HamContracts (202) 822- hamner@w
http://ww 375 Hudson St FL 12 New York NY 10014 Howard LevPrincipal (650) 230- levine@wa
http://ww 375 Hudson St FL 12 New York NY 10014 Howard LevPrincipal (650) 230- levine@wa
http://ww 375 Hudson St FL 12 New York NY 10014 Susan HamContracts (202) 822- hamner@w
www.welki102 S. Tejon Suite 20 Colorado SCO 80903 Dennis A WVice Presi (719) 520- dennis.wa
http://ww 375 Hudson St FL 12 New York NY 10014 Howard LevPrincipal (650) 230- levine@wa
www.welki102 S. Tejon Suite 20 Colorado SCO - Dennis A WVice Presi (719) 520- dennis.wa
http://ww 959 Bassett Westlake OH 44145 Ray Yoder CFO (440) 835- ray@weste
http://ww 5072 West Chester PiEdgmont PA 19028 Lavern D President (610) 356- vwedeven
www.wetla620 ApplegPO Box 51 Philomath OR 97370 Debra HamController (541) 929- debra@wet
www.wetla620 ApplegPO Box 51 Philomath OR 97370 Ian Walsh Chief of O (541) 929- ian@wetla
www.willi 200 Greenleaf St. Fort WorthTX 76107 Brent WilliVice Presi (817) 872- brent.will
2015 Nelson Ave #B Redondo BCA 90278 Prachee ShFounder &(310) 372- prsharma@
www.winte220 Eglin Suite 4 Fort WaltoFL 32548 Claude ConPresident/(850) 664- claude_con
http://ww 1020 Glen Arbor DrivEncinitas CA 92024 John R ConPresident (408) 234- jconkle@w
www.wirele10 Technology Drive Setauket NY 11733 Hoon Ahn President (631) 689- hoonahn@w
www.wirer100 Maynard Street WilliamspoPA 17701 Virgil R Pr Exec. Vice (570) 327- v.probasc
www.wetst20 ThornwSuite 105 Ithaca NY 14850 John MorriDirector o (607) 266- john@wets
2421 Glyndon Ave Venice CA 90291 William P PProprieter (310) 306- peschelwl@
www.willi 200 Greenleaf St. Fort WorthTX 76107 Brent WilliVice Presi (817) 872- brent.will
www.willi 200 Greenleaf St. Fort WorthTX 76107 Brent WilliVice Presi (817) 872- brent.will
www.willi 200 Greenleaf St. Fort WorthTX 76107 Brent WilliVice Presi (817) 872- brent.will
www.willi 200 Greenleaf St. Fort WorthTX 76107 Brent WilliVice Presi (817) 872- brent.will
www.wizd 1300 IroquSuite 140 Naperville IL 60563 Steven KrolVice Presi (630) 357- skroll@wi
www.wolft6836 Hawthorn Park IndianapoliIN 46220 Mark LewisBusiness (317) 842- mlewis@wo
4438 Chippewa Dr JacksonvillFL 32210 John T GallPresident (904) 389- jgallo@xad
www.xcoms 12345-B Sunrise ValleReston VA 20191 Todd SmithCEO (703) 868- sbir@xcom
www.xcor. 1314 FlightP.O. Box 1 Mojave CA 93502 Jeff GreasoPresident (661) 824- jgreason@
www.xcor. 1314 FlightP.O. Box 1 Mojave CA 93502 Jeff GreasoPresident (661) 824- jgreason@
www.Xdot124 Commonwealth CCharlottesvVA 22901 Erik E Swa President/(434) 296- erik@xdot
http://ww 513 ProgreSuite M Linthicum MD 21090 Ronald GodVP, Busine (410) 636- RGodlewsk
www.xcor. 1314 FlightP.O. Box 1 Mojave CA 93502 Jeff GreasoPresident (661) 824- jgreason@
4750 Rusina Rd, STE Colorado SCO 80907 Yuan Ma Chief Techn(719) 260- mary@xima
www.wwtec 4519 Mustering Dru Ellicott Cit MD 21042 Chris J WalPrincipal I (410) 418- cwalter@w
www.wwtec 4519 Mustering Dru Ellicott Cit MD - Chris J WalPresident (410) 418- cwalter@w
www.wwtec 4519 Mustering Dru Ellicott Cit MD 21042 Chris J WalPresident (410) 418- cwalter@w
www.xiom1317 Skyway Drive Ypsilanti MI 48197 John GreenCo-Owner (734) 646- johngreen
615 HOPE ROAD, BUIEATONTO NJ 07724 John McNaVP Strategi(732) 542- jmcnamara
615 HOPE ROAD, BUIEATONTO NJ 07724 John McNaSenior VP (732) 542- jmcnamara
www.yesin101 Industrial Blvd. Turners FalMA 01376 Nancy TurgFinance (413) 863- nlt@yesin
www.yesin101 Industrial Blvd. Turners FalMA 01376 Nancy TurgFinance (413) 863- nlt@yesin
615 HOPE ROAD, BUIEATONTO NJ 07724 John McNaVP Strategi(732) 542- jmcnamara
www.yardn82 Mechanic Street PawcatuckCT 06379 Vincent A YePresident (860) 599- vyevoli@li
http://www3365 Mauricia AvenuSanta Clar CA 95051 Joseph SchSBIR PM (408) 930- joe.schles
http://www3365 Mauricia AvenuSanta Clar CA 95051 Joseph SchProduct M(408) 930- joe.schles
http://ww 6302 FairvSuite 600 Charlotte NC 28210 Mary RichaExecutive V(704) 358- mrichards
www.erols1112 Clark Road Glenside PA 19038 Andrew E ZPresident (215) 233- azeger@rc
77 Wopowog Road East HampCT 06424 Ray ZatorskVP Enginee(860) 267- Zatorskico
www.erols1112 Clark Road Glenside PA 19038 Andrew E ZPresident (215) 233- azeger@rc
www.erols1112 Clark Road Glenside PA 19038 Andrew E ZPresident (215) 233- azeger@rc
www.yardn82 Mechanic Street PawcatuckCT 06379 Vincent YevPresident, (860) 599- vyevoli@li
www.erols1112 Clark Road Glenside PA 19038 Andrew E ZPresident (215) 233- azeger@rc
www.yardn82 Mechanic Street PawcatuckCT 06379 Vince YevolChief Opera(860) 599- vyevoli@li
www.zelte54 Old Hampton LaneHampton VA 23669-366Susan HughDirector, C(757) 722- susan.hug
www.yardn82 Mechanic Street PawcatuckCT 06379 Vincent YevPresident, (860) 599- vyevoli@li
www.zivko502 Airport Road, HaGuthrie OK 73044 Daniel BierTechnical (405) 282- d.bierly@z
http://www1223 Peoples Ave Troy NY 12180 Thomas ToCEO (518) 833- ttongue@z
WWW.ZIVA6160 Lusk C-206 San Diego CA 92121 Marianne KOfficie Ma (858) 550- mknight@z
www.zonat9489 E. Ironwood SquScottsdale AZ 85258 Jennifer ScProject Ma(480) 945- jennifer@
www.zonat9489 E. Ir Suite 100 Scottsdale AZ 85258 Jennifer ScAssistant (480) 945- jennifer@
www.zybro3915 Germany Lane BeavercreeOH 45431 Ron L FletcVP (937) 427- rfetcher@
zyberwear2114 New Victor RoaOcoee FL 34761 Oliver EdwPresident (407) 295- oliver@zy
935 Bailey Court UnitSan MarcoCA 92069 Robert SpotMember (925) 895- rspotnitz@
935 Bailey Court UnitSan MarcoCA 92069 Robert SpotMember (925) 895- rspotnitz@
www.ameri30 South PSuite 201 Marietta GA 30060 Tony MorriPresident (678) 784- tmorris@a
www.ameth Southern O2610 Sam Ardmore OK 73401 Sallie ReddPresident (405) 227- accounts@
www.aerog30 Forbes Building B NorthboroMA 01532 Kevin SchmVP, Operat(508) 691- contracts
www.Gryp6301 Ivy L Suite 300 Greenbelt MD 20770 Marti D'AnExecutive V(240) 387- mdangelo@
www.critic2306 Bleecker Street Utica NY 13501 Richard Ev Managing (315) 732- devans@cri
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www.optid1645 Hicks Road, SuitRolling M IL 60008 Selim ShahrPresident (847) 358- optidot@a
www.er-co2571-A Arthur Kill RoStaten Isla NY 10309 Robert De President (718) 608- rdesaro@e
186 CEDAR HILL STREMARLBOR MA 01752 Kang Lee President (508) 481- klee@aspe
www.angle7406 AlbanSuite A112SpringfieldVA 22150 Nia Strei CFO (703) 866- nstrei@ang
www.ameth Southern O2610 Sam Ardmore OK 73401 Sallie ReddPresident (405) 227- accounts@
186 CEDAR HILL STREMARLBOR MA 01752 Kang P LeePresident (508) 481- klee@aspe
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.geos2041 Rosecrans Ave., El SegundoCA 90245 Scott Batt CFO (310) 414- sbattenbu
24085 Garnier St Torrance CA 90505 John Kirk VP (310) 891- jckirkjr@a
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
24085 Garnier St Torrance CA 90505 John Kirk VP (310) 320- jckirkjr@a
PO Box 276 WynnewooPA 19096 Eric KrotkoPresident (610) 649- ekrotkov@i
200 Canal Suite 300 Rochester NY 14623 Mark L RedMember (585) 424- Mark.Redd
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William T Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.euras475 Fifth Avenue, 14tNew York NY 10017 Andrew PaAssociate (202) 903- page@eura
www.excel263 Decatur Street Atlanta GA 30312 Dmitriy MaAccountan(404) 584- dmatveyen
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
www.infosc303 Bear Hill Road Waltham MA 02451 William F Contracts (781) 890- bthompson
101 ClematUnit #1 Waltham MA 02453 Adam RoseCEO (215) 375- a.rosen@k
101 ClematUnit #1 Waltham MA 02453 Adam RoseCEO (215) 375- a.rosen@k
www.plxph8285 EL RIO, SUITE 1 HOUSTON TX 77054 Ronald R President (713) 842- ron.zimme
P.O. Box 356 Midway UT 84049 George HaPresident (435) 654- gchansen@
www.nanod 901 Fuhrmann Blvd. Buffalo NY 14203 Keith BlakeCEO (716) 853- kblakely@
www.nanod 901 Fuhrmann Blvd. Buffalo NY 14203 Glenn SpacCTO (631) 271- gspacht@n
www.nanod 901 Fuhrmann Blvd. Buffalo NY 14203 Keith BlakeCEO (716) 853- kblakely@
NA 5507 N. Paseo ventosTucson AZ 85750 James T FoDirector, C(520) 250- fountain@t
www.photo283 Great Valley Par Malvern PA 19355 Aydin yeniaDirector (484) 888- ayeniay@p
www.iac-o13029 DaniSuite 200 Poway CA 92064 Laura GoodVP, Contra (858) 679- laura.good
www.Micro600 SE AssBldg. 55 SuVancouverWA 98661 Joseph Bir President (360) 694- joseph.bi
www.iac-o13029 DaniSuite 200 Poway CA 92064 Laura GoodVP Contrac(858) 679- laura.good
16436 SE 39th Place Bellevue WA 98008 John SlougPresident (425) 319- sloughj@c
NA 9030 S. Rita Road, St Tucson AZ 85747 Jim FountaBusiness (520) 250- fountain@t
gosage.co One IvybroSuite 190 WarminstePA 18974 Julius OlitaPresident (215) 658- olitaj@gos
www.scite100 Wall Street Princeton NJ 08540 David CarriController (609) 921- dcarrick@s
www.iac-o13029 DaniSuite 200 Poway CA 92064 Laura E GoVP Contrac(858) 679- laura.good
www.coher1120 SouthBuilding 3,Austin TX 78746 Donald R GVice Presi (512) 382- gorsuch@c
www.beyon 2500 Louisiana NE, SuAlbuquerqNM 87110 Erin MathiContracts (505) 872- emathie@t
www.miru805 Gibbon St AlexandriaVA 22314 Joseph ChiPresident (703) 683- joechiara
www.tesla.2711 Jeffe Airport PlaArlington VA 22202 George StejPresident (414) 807- gstejic@tes
www.vista 1500 1st ASuite B117Birmingha AL 35203 Raymond TManager (205) 307- rthompson
lightningp 401 School House La Strafford PA 19087-908Lawrence Chief Scient(610) 331- lrome@lig
www.techn11180 Reed HartmanCincinnati OH - Narayan R Business (513) 985- nari.rama
http://ww 3000 Kent Avenue, SuWest LafayIN - Eric WalterVice Presi (765) 464- walters@p
www.gssllc12801 WorlSuite 500 Herndon VA 20170-017Larry Bach Director o (703) 871- larry@gssll
www.mo-sc4040 HypoiPO BOX 2 Rolla MO 65402-000Thomas E DPresident (573) 364- tday@mo-s
www.irobo8 Crosby Drive Bedford MA 01730-173Judith BlinDirector of(781) 430- contracts@
85 Airpark Unit #3 Ronkonko NY 11779-920Jahangir RaVice Presi (631) 645- rastegar1
www.geop605 Mercury Street Raleigh NC - Lynda RednAccountan(919) 839- redner@ge
www.i-a-i. 15400 Calhsuite 400 Rockville MD - Mark JameDirector, C(301) 294- mjames@i-
http://www 20 New England BusinAndover MA - B.David GrPresident, (978) 689- green@psi
www.verdaSuite 300e, 3000 CaboLanghornePA - Reuben VaCEO (847) 265- Reuben.Va
http://ww 209 West CSuite 107 Natick MA - Dean TanneContracts (508) 655- dean.tann
www.eigen10 Cindy Lane Holmdel NJ - Robert WarPresident (732) 673- rwarner@e
www.magno 52-B CummSuite 314 Woburn MA - Yash R.PuriExecutive (781) 503- yrpuri@mag
680 S. Ayon Ave. Azusa CA - Kurt BaumPresident (626) 334- fuoroche
http://www 1250 Lincoln Avenue,Pasadena CA 91103-2466 (626) 296- ssouthard
http:// 11424 Palatine Drive Potomac MD 20854-1451 (301) 983- RobertFin
http://ww 175 Clearbrook Road Elmsford NY 10523-1109 (914) 592- ekulinski@
www.irobo63 South Avenue BurlingtonMA 01803 Ms. Judith Blinn (781) 418- contracts@
digitalfus 5030 Bradford DriveBu Huntsville AL 35805 Mr. Mit Merritt (256) 327- mmerritt@d
111 West Main StreetBay Shore NY 11706 Jahangir RaDr. (631) 665- j_rastegar
www.prime1750 Kraft Dr Ste 100BlacksburgVA 24060 Dan KominDr. (540) 961- dkominsky
http://ww 12345 W. 52nd Ave. Wheat RidCO 80033-191Mr. John WVice Presi (303) 940- jdwright@
www.assett11220 ASSESuite 101 Manassas VA 20109-399Mr. Galen PPresident (703) 365- galen.plun
3487 W. 21Suite 100 SALT LAKE UT 84119 (801) 484- jorr@abl.med.utah.edu
P.O. Box 373 Canaan ME 04924 John WhalManager/ (207) 474- harmonbro
3500 Westgate Dr., SuDurham NC 27707 () -
2310 University Way, Bozeman MT 59715 () -
4338 N. Gunfint TrailWassilla AK 99654 Timothy S President (907) 357- tveenstra@
1622 RouteP.O. Box 6 Gales Ferr CT 06335 William J President (860) 464- wjb@appl
450 Courtney Way, UnLafayette CO 80026 () -
7547 Mentor Ave. Mentor OH 44060 () -
926 N St., NW REAR, WashingtoDC 20001 () -
5710 Flatiron ParkwayBoulder CO 80301 Curt JacksoCFO (303) 440- cfo@dropl
3261 Imjin Road Marina CA 93933 Andrew GolCFO (401) 441- ag@desert
119 Silvia St. Ewing NJ 08628 () -
5754 Pacific Center BlSan Diego CA 92121 () -
354 East 66th St., Sui New York NY 10065 () -
43670 Trade Center PlDulles VA 20166 () -
89 Rumford Avenue Newton MA 02466-131Anthony J President (781) 529- avaccaro@
28034 Holly Road Easton MD 21601 Vincent M DKirector (410) 829- vince@ges
3366 N. Torrey Pines CLaJolla CA 92037 Ahmad T ADirector a (858) 457- ahmad.aba
1668 Valtec Lane, SuiBoulder CO 80301 () -
2520 W. 237th StreetTorrance CA 90505 Lothar Ke Vice Presi (424) 263- randdoffic
P.O. Box 4239 Kailua KonHI 96745 Matt ConfeCFO (808) 331- mconfer@k
PO Box 137491 Clermont FL 34713 () -
174 Galisteo Lane Santa Fe NM 87505 () -
1777 Highland Dr., SuAnn Arbor MI 48108 () -
421 Currant Rd. Fall River MA 02720 () -
14960 Woodcarver RdColorado SCO 80921 () -
114 Higgins Road N. SearsmontME 04973 Glenn FlanCFO (207) 666- gfanders
114 Higgins Road N. SearsmontME 04973 Glenn FlanCFO (207) 666- gfanders
26610 Agoura Rd., SuCalabasas CA 91302 () -
34 Cessna Court GaithersbuMD 20879 John W PettPresident (301) 926- pettit_tec
3180 Sterling Circle Boulder CO 80301 () -
1275 Kenne Suite 100 Marietta GA 30066 Susan F DuVice Presi (678) 384- contracts
107 Sunderland RoadAmherst MA 01002 James MeaPresident (413) 549- mead@pros
3179 MainUnit 3, PO BarnstableMA 02630 James D CaCFO (508) 362- canniff2rm
2290 East Prospect RoFort Collin CO 80525 Gerald N DDirector (970) 484- jay.day@ri
1570 Pacheco St., SuiSanta Fe NM 87505 () -
7200 Highway 150 Greenville IN 47124 Mark Deuse President (812) 923- mdeuser@t
2724 Sawbury Blvd. Columbus OH 43235 () -
25-A Bisbee Court Santa Fe NM 87508 () -
4695 Millennium DrivBelcamp MD 21017 Jeff Foulk President (410) 273- jeff.foulk
2021 Miller Drive, SuiLongmont CO 80501 Stephen S President (720) 494- swilliams
105 N. Main St. North Mo ME 04351 () -
655 Phoenix Dr. Ann Arbor MI 48108 () -
3939 Glenwood Ave. Raleigh NC 27612 () -
12725 SW Millikan Wa Beaverton OR 97005 () -
2306 Bleecker St. Utica NY 13510 () -
45 Manning Road Billerica MA 01821 Charles E KPresident (978) 663- kolb@aero
15 Cabot Road Woburn MA 01801 Geoffrey BDirector o (781) 935- GBurnham@
12085 Research DriveAlachua FL 32615 John B RogPresident (386) 418- Johnro@bio
1981 North Broadway,Walnut Cr CA 94596 Steve WamC.E.O. (800) 210- info@avat
8058 El Street Houston TX 77054 Ashok GowPresident (713) 741- ashok@bio
401 West Martin DrivGoodfield IL 61742 Paul S AndVice Presi (309) 452- psanders@i
325 Water St. WilmingtoDE 19804 John BowsePresident (302) 999- jbowser@
18A Mason Irvine CA 92618 Wayne ClarPresident (949) 768- wclark@ee
111 Downey Street Norwood MA 02062 R D Rauh President (781) 769- drauh@eic
4600 Nautilus Court Boulder CO 80301 James S BeVice Presid(303) 530- contracts@
4600 Nautilus Court Boulder CO 80301 James S BeVice Presid(303) 530- contracts@
34c Holton Street Woburn MA 01801 MadeleineVice-Presi (781) 938- mkaiser@e
707 4th Street, Suite Davis CA 95616 Owen HughPresident (530) 756- owen@eonr
200 Innovation BoulevState CollePA 16803 Timonthy BPresident (814) 571- tbhurley@
39910 Jeffrey Height Temecula CA 92591 Dennis FitzOwner (951) 676- drfitz48@a
89 Rumford Ave. Newton MA 02466 Anthony B Chief Execu(781) 529- alaconti@g
2520 W. 237th StreetTorrance CA 90505 Lothar Ke Vice Presi (424) 263- randdoffic
6 Yankee Way Beverly MA 01915 Jeffrey C APresident (781) 888- alexander.
P.O. Box 368 Amherst MA 01004 J R Kittrell President (413) 549- kseinc@ao
P.O. Box 262 Negaunee MI 49866 Domenic PPresident (906) 475- popkodc@a
1155 Wiliam Pitt WayPittsburgh PA 15238 Paul K Liu President (412) 826- pliu@medi
7960 S. Kolb Road Tucson AZ 85706 Raouf O LoPresident (520) 574- rloutfy@m
410 Great Road, SuiteLittleton MA 01460 () -
5315 Peachtree IndusAtlanta GA 30341 David A SmChief Finan(678) 287- dsmith@ng
1310 Research Park DManhattanKS 66502 () -
P.O. Box 2168 Fayettevill AR 72702 Yongchen LVice Presid(479) 575- ycliu@nn-l
566 Mainstream DrivNashville TN 37228 Edward J SPresident/(615) 734- ejsommer@
511 Avondale Drive Sugar LandTX 77479 Deyang HoDirector o (281) 980- dalianqlc
12345 W. 52nd Ave. Wheat RidCO 80033 John D WriVice Presi (303) 940- jdwright@
8120 Mid America BlvOklahoma OK 73135 Bill JohnsoPresident (405) 388- bjohnson@
136 East 18th Street Tulsa OK 74119 () -
HC63 Box 1313ATok AK 99780 Martin C MOwner (907) 883- christokma
7960 S. Kolb Road Tucson AZ 85706 Raouf O LoPresident (520) 574- rloutfy@m
 12085 Research DriveAlachua FL 32615 John B RogPresident (386) 418- Johnro@bio
2520 W. 237th StreetTorrance CA 90505-521Lothar Ke Vice Presi (424) 263- randdoffic
136 East 18th Street Tulsa OK 74119 David Reis Professiona(918) 295- dreisdorp
www.eltro4600 Nautilus Court Boulder CO 80301-324James S BeVice Presid(303) 530- contracts@
8058 El Rio Street Houston TX 77054 Ashok GowPresident (713) 741- ashok@bio
707 4th Street, Suite Davis CA 95616 Owen HughPresident (530) 756- owen@eonr
18A Mason Irvine CA 92618 Wayne ClarPresident (949) 768- wclark@ee
6 Yankee Way Beverly MA 01915 Jeffrey C APresident (781) 888- alexander.
5315 Peachtree IndusAtlanta GA 30341 David A SmChief Finan(678) 287- dsmith@ng
15 Cabot Road Woburn MA 01801 Geoffrey BDirector o (781) 935- GBurnham@
45 Manning Road Billerica MA 01821 Charles E KPresident (978) 663- kolb@aero
www.eltro4600 Nautilus Court Boulder CO 80301-324James S BeVice Presid(303) 530- contracts@
200 Innovation BoulevState CollePA 16803 Timonthy BPresident (814) 571- tbhurley@
http://ww 12345 W. 52nd AvenWheat RidCO 80033-191John D WriVice Presi (303) 940- jdwright@
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HC
c/o 63 Box
Paul 1313A
Wever Tok
Construction AK 99780 Martin C MOwner (907) 883- christokma
401 West Martin Drive Goodfield IL 61742 Paul S AndVice Presi (309) 452- psanders@i
410 Great Road, SuiteLittleton MA 01460 Michael KiPresident (978) 952- mkimble@r
111 Downey Street Norwood MA 02062 R D Rauh President (781) 769- drauh@eic
34c Holton Street Woburn MA 01801 MadeleineVice-Presi (781) 938- mkaiser@e
8120 Mid America Bou Oklahoma OK 73135 Bill JohnsoPresident (405) 388- bjohnson@
1310 Research Park DManhattanKS 66502 Slawomir W Senior Scie(785) 537- slawek@na
P.O. BOX 2168 FAYETTEVI AR 72702 Yongchen LVice Presid(479) 575- ycliu@nn-l
P.O. Box 262 Negaunee MI 49866 Domenic PPresident (906) 475- popkodc@a
335 Water Street Newport DE 19804 John BowsePresident (302) 999- jbowser@
P.O. Box 368 Amherst MA 01004 J R Kittrell President (413) 549- kseinc@ao
89 Rumford Avenue Newton MA 02466-131Anthony B Chief Execu(781) 529- alaconti@g
http://ww 1155 William Pitt WaPittsburgh PA 15238 Paul K Liu President (412) 826- pliu@medi
www.mgtsc6022 Constitution Av AlbuquerqNM 87110 Marlene K President (505) 255- kay_bleme
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www.linde270 Littleton Road, UWestford MA 01886 Amaresh MPresident (978) 392- am@linden
270 Littleton Road, UWestford MA 01886 Amaresh MPresident (978) 392- am_linden
www.areteP.O. Box 6024 Sherman OCA 91413 David KaneVice Presi (520) 571- dkane@are
www.areteP.O. Box 2607 Winnetka CA 91306 David KaneVP Optical (520) 571- dkane@are
PO Box 2607 Winnetka CA 91306 () -
www.areteP.O. Box 2607 Winnetka CA 91396 David KaneVice Persid(520) 571- dkane@are
www.areteP.O. Box 2607 Winnetka CA 91306 Curt HarkleVice Presi (818) 885- charkless
www.areteP.O. Box 2607 Winnetka CA 91396 David KaneVice Presi (520) 571- dkane@are
www.areteP.O. Box 2607 Winnetka CA 91306 Curt HarkleVice Presi (818) 885- charkless
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www.areteP.O. Box 2607 Winnetka CA 91396 David KaneVice Presid(520) 570- dkane@are
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www.areteP.O. Box 2607 Winnetka CA 91396 Curt HarkleVice Presi (818) 885- charkless
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P.O. box 2607 Winnetka CA 91306 Steven E RVice-Presi (703) 413- sramberg@
3452 Lake Lynda Dr Orlando FL 32817 () -
www.vcom3452 Lake Lynda Dr., Orlando FL 32817 Carol J Wi Chief Execu(407) 737- carolw@v
3452 Lake Lynda Dr Orlando FL 32817 () -
1431 Oakcrest Ln. Provo UT 84604 Lynn Astle PhD (801) 367- LynnAstle
INTELLIGE 6860 SW 81 MIAMI FL 33143 (305) 668- emiskiel@ihsys.com
http://ww 28 Corporate Drive Clifton Par NY 12065 William J President (518) 371- will.schro
28 Corporate Drive Clifton Par NY 12065 Kenneth MDr. (518) 371- ken.marti
480 Oakmead ParkwaSunnyvale CA 94085 Eric CrossoDr. (408) 962- ecrosson@
480 Oakmead ParkwaSunnyvale CA 94085 Phillip G A Dr (408) 962- pamaya@pi
http://www2572 White Road Irvine CA 92614 Cecil F HesPresident (949) 553- cecilh@met
http://www2572 White Road Irvine CA 92614 Cecil Hess President (949) 553- cecilh@met
http://www2572 White Road Irvine CA 92614 Cecil F HesPresident (949) 553- cecilh@met
http://www2572 White Road Irvine CA 92614 Cecil Hess President (949) 553- cecilh@met
http://www2572 White Road Irvine CA 92614 Cecil F HesPresident (949) 553- cecilh@met
www.metro 2572 White Road Irvine CA 92614-623Christina LDirector of(949) 553- carnold@m
2572 White Road Irvine CA 92614-623Christina LDirector of(949) 553- carnold@m
http://www8 Chrysler Irvine CA 92618 Cecil F HesPresident (949) 553- cecilh@met
http://www8 Chrysler Irvine CA 92618 Cecil Hess President (949) 553- cecilh@met
http://www2572 White Road Irvine CA 92614 Cecil F HesPresident (949) 553- cecilh@met
http://www2572 White Road Irvine CA 92614 Cecil F HesPresident (949) 553- cecilh@met
http://www8 Chrysler Irvine CA 92618 Cecil F HesPresident (949) 553- cecilh@met
http://www8 Chrysler Irvine CA 92618 Cecil F HesPresident (949) 553- cecilh@met
www.metro 2572 White Road Irvine CA 92614-623Christina LDirector of(949) 553- carnold@m
13240 EvenSuite 311 SAN DIEGOCA 92128 (858) 384- rbilhorn@directelectron.com
3 Whitehouse Way Ringoes NJ 08551 Minkyu LeeChief Scien(908) 240- minkyul@h
3 Whitehouse Way Ringoes NJ 08551 Minkyu Leechief scient(908) 240- minkyul@h
http://www1414 Walden Oaks PlPlant City FL 33563 Roger Cha President (215) 528- roger.cha
720 BROADWAY, STE SEATTLE WA 98122 (206) 860- ebolotin@
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, C(703) 414- kelly.mccl
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, (703) 414- kelly.mccl
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, C(703) 414- kelly.mccl
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, C(703) 414- kelly.mccl
1235 South Clark StreArlington VA 22202-436Caitlin MacBusiness Of(703) 414- caitlin.ma
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, (703) 414- kelly.mccl
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, C(703) 414- kelly.mccl
http://www1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, C(703) 414- kelly.mccl
www.dac.u1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, (703) 414- kelly.mccl
www.dac.u1235 SouthSuite 400 Arlington VA 22202 Kelly McCleDirector, C(703) 414- kelly.mccl
25 South Oklahoma AOklahoma OK 73104 () -
http://www25 South Suite 300 Oklahoma OK 73104 Dee WilsonComptrolle(405) 228- dwilson@a
http://www25 South Suite 300 Oklahoma OK 73104 Dee WilsonComptrolle(405) 228- dwilson@a
528 N Tejon St Colorado SCO 80903 (719) 592- dan@ablel
528 N Tejon St Colorado SCO 80903 (719) 592- steve@able
528 N Tejon St Colodado SCO 80903 (719) 592- dan@ablel
528 N Tejon St Colorado SCO 80903 (719) 592- dan@ablel
87 Church Street East HartfoCT 01608 Peter Solomon (860) 528- peter.r.so
6901 East Fish Lake RMaple GroMN 55369 (763) 463- gseifert@
6901 East Fish Lake RMaple GroMN 55369 (763) 463- dhedin@am
1011 N. Church StreeGibson Cit IL 60936 Roland GarBusiness (217) 355- roland.gar
1015 NW Clifford Pullman WA 99163 Craig S FreManager (208) 413- csfrear@y
220 Chester Street Menlo Par CA 94025 Susan C DuCEO (650) 328- susancdun
1436 E. Beacon Way Carmel IN 46032 Timothy MPresident (765) 860- aps1436@a
1728 Kelly Park Rd Apopka FL 32712 Richard L Director (407) 468- rick@agris
8737 Colesville Road Silver Spri MD 20910 (301) 495- clathan@a
3610 NW 42nd TerracGainesvilleFL 32606 LeeAnn App Chief Execu(352) 376- aplsci@bel
108 Industrial Avenu Jefferson LA 70121 Douglas G Managing (504) 837- douglas@be
1202 Ann St. Madison WI 53713 Terrence P President (608) 843- tpbarry@ch
410 West Harrison St,Columbia WA 98119 Eric Rey President (530) 750- eric.rey@a
4145 North Downer MilwaukeeWI 53211 Lew Friedland (414) 736- lfriedla@g
4145 North Downer MilwaukeeWI 53211 Lew Friedland (414) 736- lew.fried
924 Corridor Park BlvKnoxville TN 37932 Robert BrigProject Ma(865) 777- rbriggs@a
114 E. Speedway Dermott AR 71638 Andrew WaBusiness A(870) 866- awargoiii@
1620 Rodgers St, SuitMissoula MT 59802 Robert Se CFO - Info (406) 541- rseccomb@b
16481 CR 319 Lynn GNavasota TX 77868 Daniel B WCEO and M(936) 825- beebuzzbo
790 Orchard Drive Louisville CO 80027 Guy FrommGeneral M(303) 939- gfromme@b
250 QUADE DRIVE CARY NC 27513 Deanna Nelson (919) 678- dnelson@bi
4734 Bridle Path Ct. Dublin OH 43017 I-Ching TanPresident (614) 761- bictang@sb
2912 Syene Road Madison WI 53713 Eric G HornResearch Sc(608) 332- ehorn@bio
PO Box 2428 State UniveAR 72467 David N RaManaging D (870) 972- dradin@as
1606 Golden Aspen Dr Ames IA 50010 Doyle E WiPresident (515) 296- dewilson@b
2637 27th Avenue SoMinneapoliMN 55406 (612) 724- dianne@blu
2919 Syene Road Madison WI 53713 David Baldwin (608) 237- dbaldwin@
12 clematis Avenue Waltham MA 02453 Richard J HSenior Vice(781) 899- higgins@c
12 Clematis Avenue Waltham MA 02453 Richard J HSenior Vice(781) 899- higgins@c
41 East 11th Street New York NY 10003 Chris Camacho (212) 905- chrisc@chi
P. O. Box 5708 Lincoln NE 68505 Bryan C RicPresident (402) 484- brickerts
325 Water St. null WilmingtoDE 19804 Nadine CraGrants & F(302) 999- nlester@c
335 Water St. Newport DE 19804 Louis DiNetBusiness (302) 999- ldinetta@
1144 E. Johnson Stre Madison WI 53703 Robert Sahaghian (608) 215- robert_sa
5610 Crawfordsville IndianapoliIN 46224 () -
11609 Lake Potomac Potomac MD 20854 Peixuan Zhu (240) 453- pzhu@crea
1754 Quarry Lane Valley ForgPA 19482 (610) 783- info@danc
P.O. Box 7965 BainbridgeGA 39819 Daniel Car Founder a (229) 248- dcarraway
605 Thornhill Road Danville CA 94526 Leo D PedePresident (925) 820- dantec@att
2453 Atwood AvenueMadison WI 53704 Dan RoonePresident (608) 442- dan.roone
3810 Concorde Parkwa Chantilly VA 20151 Bruce FergPresident (785) 539- ferguson@
18A Mason Irvine CA 92618 Wyman ClaPresident (949) 768- wclark@ee
710 Asp Ave., Suite 5 Norman OK 73116 Chad B RollVP Researc(405) 307- cbroller@e
710 Asp Avenue, SuitNorman OK 73069 Chad B RollVP Researc(405) 307- cbroller@e
4600 Nautilus Court Boulder CO 80301 Eileen E S Vice Presid(303) 530- esammells
4211 24th Ave West Seattle WA 98199 Steve J DidProject D (206) 634- steve@com
23575 Cabot Blvd. SteHayward CA 94545 Keith KeplePresident (510) 732- kkepler@fa
2601 Maguire Blvd Columbia MO 65201 Henry Liu President (573) 442- fpc_liuh@
PO Box 636, 324 NorfEast CanaaCT 06018 Matthew FPresident (860) 824- benjamin.
2521 Elwood Drive, SAmes IA 50010 John P ReaResearch (515) 292- jreardon@f
200 Innovation Blvd. State CollePA 16803 Stephanie President &(814) 237- stephanie
78-6772 Makenawai SKailua-KonHI 96740 Pamela Cooper (808) 322- info@origi
153 Junction Road MocksvilleNC 27028 Scott A CalManaging P(336) 406- sac@gtcall
1313 West Ashley RivCharlestonSC 29407 Robert L FrProgram M(614) 760- bobfreebur
141 washington StreeEast WalpoMA 02032 Kushal TaluDir. of Res (508) 850- kushal@har
325 Jefferson St., Sui Jefferson CMO 65101 Danny LewiDirector (573) 324-5186
76 Quarry Rd. Wolcott VT 05680 Jodi Lew-S Director o (802) 472- jodi@high
2048 Analysis Drive SBozeman MT 59718 Robert CraPresident, (406) 556- crabtree@h
2502 Corona Road Columbia MO 65203 Jason CaferCEO (573) 445- painfully
11323 Amherst Aven Wheaton MD 20902 (301) 942- corinne@i
562 1st Ave. South, S Seattle WA 98104 Raymond Houghton (206) 344- raymond@i
14227 Reed Farm WaGaithersbuMD 20878 Tom SullivaCFO (301) 279- tdsullivan
19332 Richroy Court Parkton MD 21120 Johathon APresident (410) 357- javf@comc
2310 150th St Ames IA 50014 Delbert HarCTO (515) 294- hharris@ia
2600 Dorr Street Toledo OH 43607 Alan McMaPresident (419) 724- amcmaster
425 River Rd. Athens GA 30602 Clifton A BaCEO (706) 542- cbaile@ug
P.O. Box 5266 Riverside CA 92517 Agenor Mafra-Neto (951) 686- agenor1@i
2060 Chicago Ave, #CRiverside CA 92507 Agenor Maf CEO (951) 686- president@
2060 Chicago Ave, #CRiverside CA 92507 Agenor Maf CEO (951) 686- president@
Post Office Box 2224 Guayama PR 00785 James Ruhlman (787) 866- casitadri
3465 Waialae AvenueHonolulu HI 96816 Brian GoldsCEO (808) 732- bgoldstei
PO Box 11306 Eugene OR 97440 (541) 346- rik@coglin
PO Box 11306 Eugene OR 97440 (503) 725- foxl@ohsu
47 Ocean Drive Maricopa ME 04011 Lilliana Jo President (207) 721- lillianagw
1014 Industrial AccesWest PointMS 39773 Edward TodOwner (662) 494- etodd@cpj
7610 Eastmark Drive College StaTX 77840 G. D HitcheVice Presi (979) 693- duncan.hi
7610 Eastmark Drive College StaTX 77840 G. D HitcheVice Presi (979) 693- duncan.hi
7610 Eastmark Drive,College StaTX 77840 G. D HitcheVice Presi (979) 693- duncan.hi
7607 Eastmark Drive,College StaTX 77840 Mark J Flu Research A(979) 693- mark.fus
1360 Willow Road, # Menlo Par CA 94025 Elizabeth WGovernment (650) 543- egweiss@m
2011A Lamar Drive Round RocTX 78664 Donald Wright (512) 218- don.wrigh
510 E. Kent Ave. Missoula MT 59801 Clifford Br Partner (406) 544- cbradley@
882 S. Matlack StreetWest ChestPA 19382 Koon Pak President (610) 738- cpak@mtar
411 Massachusetts ACambridgeMA 21390 Keith Donaldson (617) 576- karl@moly
411 Massachusetts ACambridgeMA 21390 Keith Donaldson (617) 576- keith.don
321 State Route 129 Walpole ME 04573 William MoPresident (207) 563- mooksea@t
115 North Wright BroSalt Lake CUT 84116 (801) 326- harold@ut
3109 South FrontenacSeattle WA 98108 Keith E Bowers (206) 725- keithbowe
457Tremont Drive Ruston LA 71270 Yuri Lvov President (318) 257- ylvov@late
100 Technology Dr. SuPittsburgh PA 15219 LacramioarChief Scien(412) 770- lschulte@
404 Enterprise Drive Lewis CentOH 43035 Andrew R PContracts &(614) 842- patton@ne
334 Hecla Street Lake LindeMI 49945 Ellen R Ca Vice Presi (906) 296- ellenr@nit
535 W. Research Ctr. Fayettevill AZ 72701 Mark Wagst Vice Presi (479) 571- mwagstaff@
3130 Summit Sky BouEugene OR 97405 (541) 505- obslap.res
19712 South SouthenOregon CitOR 97045 Dan Holco President (503) 557- oresoil@a
15 Lenape Avenue Rockaway NJ 07866 Lawrence M President (973) 983-0813
7126 180th Ave NE SuRedmond WA 98052 David Put Director (425) 497- putnam@ph
111 Woodmere Boulev WoodmereNY 11598 (516) 668- schipper@
RR 1 Box 38 Portland ND 58274 Paul StocktOwner (701) 786- sensit@po
7 Peaceful Drive Ithaca NY 14850 Debra A Scu President (518) 366- dscullary
PO Box 302 WaldoboroME 04572 ChristopherDirector o (207) 832- cdavis@mi
5 Radnor Corporate CRadnor PA 19087 Mark SwanVice Presi (610) 964- swanson@
10233 Chapman HighSeymour TN 37865 Daniel W President (865) 385- mcdonaldd
220 Reservoir Street Needham H ME 02494 Karen K CaPresident (781) 449- kcarpente
105 Carmel Road Wheeling WV 26003 Jeanne Finstein (304) 242- jfinstein@
200 Boston Avenue, SMedford MA 02155 Benjamin BPresident (781) 391- Bbikson@p
337 Tom Brown RoadMooresto NJ 08057 Wai T Law President (856) 231- wailaw@po
14514 Creek CrossingOrland ParIL 60463 George D SCheif Techn(708) 403- sadler@pr
7073 Dexter-Ann ArbDexter MI 48130 John CunnPresident (734) 786- jcu@rapid
12345 W. 52nd Ave. Wheat RidCO 80033 John D WriVice Presi (303) 940- jdwright@
4319 South 36th StreArlington VA 22206 (703) 820- contact_u
2510 Wilmette Ave Wilmette IL 60091 (847) 853- hyungsoon
1212 Fourier Drive SuMadison WI 53717 William L PManaging (608) 229- williamljp
11 Twin Rivers Drive Wiscasset ME 04578 James DetePresident (207) 882- detert@ry
2526 E. Blacklidge DrTucson AZ 85716 Gordon War President (520) 670- gordyaw@a
5032 S. As suite 101 Tempe AZ 85282 Stanley P Desjardins (480) 820-2032
22 Monument Square, Portland ME 04101 Patricia PinPresident (207) 321- ppinto@ma
12900 Snow Road Parma OH 44130 Nicholas J President (216) 676- nicksmila
2200 E Franklin Aven MinneapoliMN 55404 Greg Sales (612) 721- gsales@se
2200 E Franklin Aven MinneapoliMN 55404 Greg Sales (612) 721- gsales@se
17950 E. Dorado DrivCentennialCO 80015 Ron CravenPresident (913) 681- ron.craven
3221 N Sheridan Rd Peoria IL 61604 Heather H Co-Founde(309) 682- hgrichnik@
5477 Gene Sarazen DrBillings MT 59106 Michael G Owner (406) 690- mike@smkp
9940 Summers RidgeSan Diego CA 92121 Peter DieraVP Technol(937) 767- pdierauer
606 Ball Street Perry GA 31069 Walker L T President (478) 988- sei@alltel.
1770 N Research Par North LogaUT 84341 Shawn Edmondson (435) 753- sedmonds
1770 N Research Par North LogaUT 84341 Shawn Edmondson (435) 753- sedmonds
314 Circle Dr. P. O. B Fort TottenND 58335 AnnMaria Vice-presi (310) 717- annmaria@s
P. O. Box 1352 WellingtonCO 80549 JOAN SNYDCEO (518) 758- SNYDER@F
7723 Kempfer Lane Verona WI 53593 Robert D CPresident (608) 826- colema95
3 Trovita Irvine CA 92620 Dale A KiefPresident (310) 678- kiefer@ru
3850 Research Park DAnn Arbor MI 48108 Maria A T President (734) 213- mthompson
2350 North Forest RoGetsville NY 14068 Kevin Chugh (716) 830- chugh@tac
892 Westpark Ave N Huron SD 57350 Ardon T Mo President (605) 352- tmorse@cl
500 Technology FarmGeneva NY 14456 Terry SpittlResearch D(315) 787- tds2@corne
273 Granite Street Ashland OR 97520- (617) 407- nitzberg@b
PO Box 1290 Sumner WA 98390 Jim BarfootPresident (253) 863- jbarfoot1
162 Collins Road NE Cedar RapiIA 52402 Paul StamaPresident/(319) 622- pstaman@tr
200 East 135 South ProvidenceUT
626 MassacSuite 5 CambridgeMA
1300 Old Plank Road Mayfield PA
455 W. 23rd, 14F New York NY
1700 Brannum Lane Yellow Spr OH
1602 Animas Place Loveland CO
2353 Sapphire Lane East Lansi MI
626 Whitney St San LeandrCA
384 South Suite 200 Lindon UT
22121 20th Avenue SBothell WA
981-B Industrial RoadSan CarlosCA
425 Oser Avenue Hauppaug NY
P.O. Box 1 126 Ridge Lansing NY
87 Church Street East HartfoCT
6901 East Suite #190Maple GroMN
45 Manning Road Billerica MA
200 Finn Ct FarmingdalNY
895 Dove Street, 3rd Newport BCA
15 Cabot Road Woburn MA
310 Via Vera Cruz, SuSan MarcoCA
7822 Whistling Pines Ellicott Cit MD
44 Hunt Street WatertownMA
44 Hunt Street WatertownMA
44 Hunt Street WatertownMA
3006 LonghSte. 107 Austin TX
3006 LonghSte. 107 Austin TX
9977 Valley View RoaEden PrairiMN
5094 Victoria Hill Dri Riverside CA
727 Airport Boulevar Ann Arbor MI
14900 ConfSuite 225 Chantilly VA
100 MatawSuite 350 Matawan NJ
474 Phoenix Drive Rome NY
1420 Spring Hill RoadMclean VA
6105 S. As Suite A3 Tempe AZ
396 FentonSuite 601 West ChicaIL
1703 SouthSuite 400 Roanoke VA
2501 Monarch StreetAlameda CA
104 Centre Court Radford VA
200 Canal View Blvd Rochester NY
107 Audubon Road # Wakefield MA
15400 CalhSuite 400 Rockville MD
15400 CalhSuite 400 Rockville MD
15400 CalhSuite 400 Rockville MD
CA Santa Clar CA
One Battery Park PlazNew York NY
209 Dartmouth DriveAlbuquerqNM
9601 Baltimore Ave, SCollege Pa MD
84332 Carl S Han Vice Presid(435) 760- cshansen@
02139 John FallonVP Enginee(617) 491-0407
18433 Paul GrewaChief Opera (570) 281- pgrewal@v
59715 Will SwearVice Presi (406) 640- wds@mont
45387 Michael DzSenior Scie(937) 767- mdziewatk
80538 David B AnPresident (970) 663- andersond
48823 John F FossPresident (517) 355- foss@egr.
94577 Mahadevan President (510) 483- krishnan@
84042 Diana HadlBusiness (801) 377- dhadlock@
98021-440Robert AfzaVice Presi (425) 482- rob.afzal@
94070 Charles K GVice Presi (650) 598- cgary@ade
11788- Joe F LucasContracts (631) 273- kcleary@li
14882 Alex DeyhiPresident (607) 533- alex.deyh
06108 Karin Dutt Manager, C(860) 528- karin@AFR
55369- Thomas E HV.P. / Bus (763) 463- thendrick
01821 Charles E KPresident (978) 663- kolb@aero
11735 Godfrey Vas Chief Techn(631) 424- rmcquilla
92660 Ben BavariPresident (949) 644- ben.bavari
01801-100Sharon TanAccountin (781) 935- stan@agilt
92078- Bill CardosPresident (760) 752- bcardoso@
21043 Tia Gao President (650) 799- grants@ai
02472 Gerald EntiPresident (617) 668- jgladston
02472 Gerald EntiPresident (617) 668- GEntine@R
02472 Gerald EntiPresident (617) 668- GEntine@R
78758 Richard L FVP, Engine (512) 339- dfink@appl
78758 Richard L FVP, Engine (512) 339- dfink@appl
55344-355Rick Edin Contracts (952) 829- redin@atc
92506 Elena B BeCEO (951) 682- bekyarova
48108-163Daniel K JarContracts (734) 668- proposals
20151 Mike Fox Director o (703) 961- mfox@cruci
07747 Dana S AlePresident (732) 203- dana@daxt
13441 Gloria J Kl Vice Presi (315) 838- gloria@do
22102-300Jiemin Jor President (703) 728- jiemin@en
85283 Martin A MPresident (480) 460- Martin.Ma
60185 Robert M KPresident (630) 293- bobk@epsi
24016 Michael E Director of(540) 769- pruzanm@l
94501-931Roger D O Director o (510) 523- hescohq@a
24141 Robert C HSecretary- (540) 639- bhazelton
14623 Carol E MaContracts (585) 424- carol.mar
01880 Diane J RyaChief Finan(781) 246- dryan@imp
20855 Mark C JamDirector, C(301) 294- mjames@i-
20855 Mark C JamDirector, C(301) 294- mjames@i-
20855 Mark C JamDirector, C(301) 294- mjames@i-
95054-100Behzad Mos CEO/CTO (408) 565- bm@ifos.c
10004 Michael ThDirector of(212) 809- mthieme@b
87102 Rick Dove Vice Presi (505) 586- rkdove@ear
20740 William A President (443) 283- waa@komo
4155 W Lum Wash CtTucson AZ 85745 Jason M DoPresident (520) 743- jason.doug
1020 Corporation Way Palo Alto CA 94303 SoenkyungOperation (650) 325- pak@linea
2501 Earl Rudder Fre College StaTX - Cynthia BarProposal C(979) 693- cindy.barn
7610 Eastmark Drive College StaTX 77840 Cynthia BarProposal C(979) 393- cindy.barn
7610 Eastmark Drive College StaTX 77840 Cynthia BarProposal C(979) 393- cindy.barn
200 Boston Avenue SuMedford MA 02155 Petra BothChief Finan(781) 306- pbotha@m
1050 Winter Street S Waltham MA 02451 Alper K Ca President (781) 839- acaglayan
115 N Delaware Ave ManhattanKS 66502 Jeffrey Bla President (785) 537- jcblackwel
517 South Raymond Pasadena CA 91105 William RoPresident (626) 578- royea@nex
517 South Raymond Pasadena CA 91105 William RoPresident (626) 578- royea@nex
Sturbridge10 Picker SturbridgeMA 01566 Paul L WhitPresident (508) 347- pwhite@nov
Suite 2108,PO Box 46 Vestal NY 13851 Jin Luo (607) 233- jluo@NSCT
4850 Hahns Suite 200 Loveland CO 80538 Stephanie Contract (970) 461- smueller@
828 Fort Street Mall Honolulu HI 96813 Robert J RiProposal (808) 531- rrivero@oc
15 Craig Road Acton MA 01720 Paul JohnsVP Contrac(978) 263- johnson@p
20600 Gramercy PlaceTorrance CA 90501 Gordon DrChief Finan(310) 320- gdrew@po
20600 Gramercy PlaceTorrance CA 90501 Gordon DrChief Finan(310) 320- gedrew@p
20600 Gramercy PlaceTorrance CA 90501 Gordon DrChief Finan(310) 320- gdrew@po
20600 Gramercy PlaceTorrance CA 90501 Gordon DrChief Finan(310) 320- gedrew@p
20600 Gramercy PlaceTorrance CA 90501 Gordon DrChief Finan(310) 320- gedrew@p
2925 Boardwalk Ann Arbor MI 48104 Robin R RisCFO (734) 864- rrisser@pi
5764 PacifiSuite 107 San Diego CA 92121 Gayle A GuProposal (858) 348- gayle@qua
2151 Las PSuite C Carlsbad CA 92011 Louis HaerlVP Operati(858) 449- louis@seac
3000 Bryker Drive Austin TX 78703-183Curt Bilby President (512) 459- curt.bilb
2595 Rossmere StreeColorado SCO 80919 James R WiPresident (719) 265- jwittenbur
201 Circle Unit 102/1PiscatawayNJ 08854 Gary S TomPresident (732) 302- gstompa@s
215 Parkway North Waterford CT 06385-120Jane GoldsProposals (860) 442- goldjane@
2021 Miller Drive, SuiLongmont CO 80501 Stephen S President (720) 494- swilliams
11750 Belts3rd Floor Beltsville MD 20705 Amy HizouVP, Financ (240) 790- aph@techn
6800 Cortona Drive Goleta CA 93117 Marcella RDirector of(805) 968- mlindbery
1594 State Street Schenecta NY 12304 Donald D CGeneral M(518) 370- dcolosimo
2100 KramSuite 250 Austin TX 78758 Miguel A CPresident (512) 589- smarr@tri
200 Turnpike Road Chelmsfor MA 01824 Bonnie S HContracts (978) 250- contracts@
2417 Mill Heights DriHerndon VA 20171 Matthew SChief Execu(703) 742- mschor@al
11150 W. OSuite 1020Los AngeleCA 90064 Jacob YadeCEO (310) 473- jacob@uto
200 Greenleaf Street Fort WorthTX 76107 James A GrController (817) 872- james.grov
2415 San RSte 4-163 San RamonCA 94583 Adel GhanPresident (925) 736- adel@zont
2571-A Arthur Kill RoStaten Isla NY 10309 Robert De President (718) 608- rdesaro@e
303 Bear Hill Road Waltham MA - William F Contracts (781) 890- bthompson
ABIOMED, 22 CHERRYDANVERS MA 01923 ROBERT T KUNG (978) 777- rkung@ab
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ABQMR, IN2301 YALE ALBUQUERNM 87106 EIICHI FUKUSHIMA (505) 244- eiichi@ab
ACADEMIC108 E. 14thBLOOMINGIN 47408 RICHARD GOLDSWOR(812) 333- rick@acad
2113 WELLS BRANCHAUSTIN TX 78728 (512) 784-1861
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ACELOT, IN5385 Holli SANTA BA CA 93111 AMBUJ K SINGH (805) 680- ambuj@cs.
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ACUCELA I21720 23rdBothell WA 98021 DAVID W LEUNG (425) 527- dwleung@a
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AGENNIX, I8 GREENWA HOUSTON TX 77046 MINNETTE S SMITH () - msmith@ag
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AGENTSHEE 6560 GUNPBOULDER CO 80301 NADIA REPENNING (303) 530- nadia@age
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AIKO BIOT 2 Union StPORTLANDME 04101 (207) 329- jwrona@su
AKAZA RES1 KENDALLCAMBRIDGMA 02139 CAL COLLINS (617) 621- ccollins@a
AKINA, INC1291 CUMB WEST LAFAIN 47906 KINAM PARK (765) 464- kp@akinai
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44 Hunt Street WatertownMA 02472 GERALD ENTINE (617) 668- GEntine@
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44 Hunt Street WatertownMA 02472 GERALD ENTINE (617) 668- nmarshall
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44 Hunt Street WatertownMA 02472 GERALD ENTINE (617) 668- GEntine@R
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PI NamePI Title PI PhonePI EmailRI NameRI POC RI POC Researc Abstract
Fredrik ValCTO (805) 696- fredrik@webwisesecurity.com
Jeffrey L CiAssociate (212) 367- cipolla@wai.com
David VaugPrincipal (650) 230- vaughan@wai.com
Paul ReynoAssociate (650) 230- reynolds@wai.com
Paul ReynoPrincipal I (650) 230- reynolds@wai.com
J. T Todd RPrincipal I (719) 520- todd.reinking@welkinsciences.com
Darren TenPrincipal (505) 872- tennant@wai.com
Blair E SawPrincipal I (719) 520- blair.sawyer@welkinsciences.com
James DeFrVice Presid(440) 835- jd@western-data.com
Lavern D President (610) 356- vwedeven@wedeven.com
Cristina M Sr. Researc(541) 929- cris@wetlabs.com
Michael TwVice Presi (401) 783- mtwardo@wetlabs2.com
Chris StimeElectrical (817) 872- chris.stimek@williams-pyro.com
Prachee ShProgram M(310) 372- prsharma@att.net
Fred BenedVP, System(850) 664- fred_benedick@wintec-inc.com
John R ConPresident (408) 234- jconkle@wisen-tech.com
Hoon Ahn President (631) 689- hoonahn@wireless-technology.net
Michael F Supt. Plant(570) 327- m.catino@wireropeworks.com
Chester D Sr Vice Pre(607) 266- chet@wetsNORWICH EUric W Bra (802) 485-2140
William P PProprieter (310) 306- peschelwl@earthlink.net
Andy Stell Electrical (817) 872- andy.stell@williams-pyro.com
Nithya Ra Electrical (817) 872- nithya.ramaswami@williams-pyro.com
Peter GardEngineer (817) 872- peter.gardner@williams-pyro.com
Chris StimeEngineer (817) 872- chris.stimek@williams-pyro.com
Steven KrolVice Presi (630) 357- skroll@wizdom.com
Michael PePrincipal I (317) 842- mpepe@wolftechnical.com
John T GallPresident (904) 389- jgallo@xadairtech.com
David Eris CTO (703) 390- sbir@xcomsystems.com
Dan DeLonChief Engi (661) 824- ddelong@xcor.com
Doug JonesChief Test (661) 824- djones@xcor.com
Erik E Swa President/(434) 296- erik@xdotea.com
Kevin PageChief Tech (410) 636- KPage@Xenotran.com
Dan DeLonVice Presi (661) 824- ddelong@xcor.com
Xiqun Zhu Principal E(719) 260- xiqun@ximax-tech.com
Chris J J WaPresident (410) 418- cwalter@wwtechnology.com
Chris J J WaPrincipal I (410) 418- cwalter@wwtechnology.com
Chris J J WaPrincipal I (410) 418- cwalter@wwtechnology.com
John GreenCo-Owner (734) 646- johngreen@xiomas.com
Junghoon LScientist (732) 460- jlee@xprtsol.com
Junghoon LPrincipal I (732) 460- jlee@dsci.com
Mark C BeaSr. Enginee(413) 863- mcb@yesinc.com
Mark C BeaSr. Enginee(413) 863- mcb@yesinc.com
George ElmPresident (732) 460- gelmasry@xprtsol.com
Joseph GnaMaterial Sc(860) 599- joeg@lithion.com
William DeCTO (408) 242- william.deninger@yottanav.com
William DeCTO (408) 242- william.deninger@yottanav.com
Cyber networks have evolved into a ubiqu
New metamaterials promise to improve ra
In Phase I of this effort we analyzed the st
WAI will develop a suite of User Toolkits f
Weidlinger Associates Inc (WAI) will devel
Welkin Sciences proposes to develop the
Predicting the response of building compo
Welkin Sciences proposes to formulate a c
Under the Phase I , Western DataCom dev
Test methods for scuffing and fatigue are
The objective of the proposed work is to d
An inherently scalable solution for determ
Williams-Pyro is developing an AccuTag M
MANETs are highly susceptible to fuctuati
Current methodologies for integration of
This program will develop a thin film pass
A novel, cost-effective Digital Beamforme
A design evaluation of possible IWRC type
The proliferation and sophistication of ma
Development of an existing microwave ge
Effective fire suppression is a key contribu
The DMEA needs a fexible, miniature, rec
The same power-hungry electronics that g
Current surveillance systems often use mo
The objective of this research is to develo
Innovative energy absorbing systems and
This proposal describes XTI’s plan for eval
X-COM Systems' proposed solution is a co
XCOR proposes to develop a family of sma
XCOR is proposing to study the combinati
The efficiency of electric motors and gene
The Xenotran Corporation and PrismTech
XCOR’s Air Force-funded work under the P
This Small Business Innovation Research P
In Phase I WWTG will develop enabling to
MILS,Infor Certification of systems with Information
Modern nuclear submarines deploy many
A low power, lightweight hyperspectral im
This proposal is to develop an Ultra High F
This proposal is to develop a SATCOM too
DoD is required to comply with EPA accep
The need for atmospheric pressure, temp
This proposal is to investigate IntServ sign
Yardney Technical Products, (YTP) propose
Yotta Navigation proposes to develop the
Yotta Navigation proposes to develop the
Jason ShifPrincipal I (704) 358- jshifet@zapeng.com
Burton S AExecutive V(215) 576- zeger@rcn.com
Ray ZatorskVP Enginee(860) 267- Zatorskico@comcast.net
Burton S AExecutive V(215) 576- zeger@rcn.com
Burton S AExecutive V(215) 576- zeger@rcn.com
Joseph GnaResearch Sc(860) 599- joeg@lithion.com
Burton S AExecutive V(215) 576- zeger@rcn.com
Arthur DobResearch Sc(860) 599- adobley@lithion.com
Oleg GodinSenior Res(303) 497- oleg.godi THE UNIV. Randall D (303) 492- ELECTROMA
Arthur DobResearch Sc(860) 599- adobley@lithion.com
ChristopheVP Enginee(405) 282- c.t.morse@zivko.com
Jianming DSenior Eng(518) 833- jianming.dai@zomega-terahertz.com
Anis HusaiCEO (858) 735- ahusain@ziva-corp.com
Ping C Chi Principal I (480) 945- pc@zonatech.com
Danny Liu President (480) 945- danny@zon ARIZONA SCindy Have(480) 965-7381
Evan ZhangResearch D(937) 427- evanzy@ameritech.net
Oliver EdwPrincipal E(407) 295- oliver@zyberwear.com
Jiang Fan President (858) 679- jfan@americanlithiumenergy.com
Jiang Fan President (760) 591- jfan@americanlithiumenergy.com
Richard CoEngineeri (404) 894- rick.cowa GEORGIA IRichard Co(404) 894-3270
Wayne HollSenior Rese(405) 227- admin@amethystresearch.com
Roxana TrifSenior Res(508) 466- rtrifu@aerogel.com
James Bru Project Ma(301) 866- jbrueggemann@gryphonlc.com
Jonathan PTechnical D(315) 732- jknauth@criticalimaging.net
Stephan AtChief Engi (727) 548- sathan01@tampabay.rr.com
Shih TsengStaff Scient(847) 358- stseng7@aol.com
Arel WeisbProgram M(718) 608- aweisberg@er-co.com
Craig ThomSenior Eng(508) 481- cthompson@aspensystems.com
William R CEO (703) 866- wschmidt@angleinc.com
Wayne HollSenior Rese(405) 227- holland@amethystresearch.com
Neng Ye Materials S(508) 481- neng@aspe UNIV. OF Richard F (617) 287-5377
Anna GaleaDirector o (781) 890- agalea@infMAYO CLINMarilyn M (480) 301-6057
Robert MulProject En (781) 890- rmulligan@infoscitex.com
Kristen LeRGroup Lead(781) 890- kleroy@infMAYO CLINLaura Bruz(507) 538-1292
Robert KovPrincipal S (781) 890- bkovar@infTEXAS STATGary Beall (512) 245-2156 The titanium sheath that currently protec
Jeremiah SManager, E(781) 890- jslade@infoscitex.com
Kristen LeRGroup Lead(781) 890- kleroy@infoscitex.com
Andrew HoStaff Engin(781) 890- ahoude@infoscitex.com
Vladimir GSenior Eng(781) 890- vgilman@in COLORADOChris Getz (970) 491-0439
Heather KaProject En (781) 890- hkauth@infoscitex.com
Rob Gillen Project En (937) 429- rgillen@infoscitex.com
Kristen LeRProject En (781) 890- kleroy@infoscitex.com
Zhiqing ChPrincipal (937) 255- zcheng@infoscitex.com
James BelcManager, A(781) 890- jbelcher@infoscitex.com
Jason ChenDirector o (310) 414- jchen@geoUNIV. OF Elizabeth H(213) 821-1106
Mehrdad SPI (301) 263- msoum@eng.buffalo.edu
John PlayerManager, M (781) 890- jplayer@infoscitex.com
ZAPATAENGINEERING will determine the s
This proposal examines several methods f
The printing of nano-structured particles
This proposal presents a novel method fo
Zeger-Abrams Incorporated (ZA) proposes
The objective of this proposal is to demon
This proposal examines a combination of
One of the major challenges of developin
Detection of weak oceanic currents by rem
This Small Business Innovation Research P
ZAI proposes to investigate advancing the
We will develop a compact THz system wi
Ziva with team member UCSD propose a
The ZONA Team proposes to develop a no
ZONA Team proposes in Phase II to develo
During the Phase-I research we only spen
This SBIR Phase I project will develop a ha
This proposal exploits nano-materials to a
This proposal describes a superior high-en
American Maglev Technology, Inc. (AMT)
The yield and operability of high performa
A diver's ability to perform dexterity work
The contractor shall work in concert with
This proposal addresses the need for a fe
This proposal describes an innovative rad
Under the Phase I project, we have develo
Energy Research Company (ERCo) propos
A fameless personal water heater will be
The proposed task creates the design for
High-performance infrared detectors are
A supported metal hydride with high grav
Simulator sickness prevents the use of sim
The noise signature of the USMC Expediti
Modern prosthetics have improved signifi
Vector borne diseases have posed a signifi
Unites States Navy, United States Air Forc
Sanitation and disinfection of food produc
All forms of transmissible spongiform enc
Tracking of nuclear materials, military ord
Advanced Network Centric Warfare (NCW
Hearing protection which targets the airb
Infoscitex proposes an innovative seating
This proposal addresses the space optic c
Maps are an incredibly rich source of info
Goleta Star LLC with support from academ
IST is proposing to integrate electrical con
Vladimir GSenior Eng(781) 890- vgilman@infoscitex.com DNA aptamers are promising highly-speci
Robert MulProject En (781) 890- rmulligan@infoscitex.com The Expeditionary Fighting Vehicle (EFV) h
Cheng PaoPI (310) 320- CPao@quinstar.com Goleta Star LLC with support from Academ
Eric KrotkoPresident (610) 649- ekrotkov@iUNIV. OF TCourtney D(512) 471-2336 The proposed work addresses the problem
Andreas voMember (541) 387- Andy@hoodtech.com In this proposed work, goal of Hood-Impa
Lynn BardsManager, S(518) 869- lbardsley@infoscitex.com Since the start of U.S. involvement in the
Gordon Hi Vice Presid(518) 869- ghirschman@infoscitex.com Dehydration has considerable negative eff
Robert KovPrincipal S (781) 890- bkovar@infoscitex.com The sophisticated technology of U.S. milit
Anna GaleaDirector o (781) 890- agalea@infoscitex.com Improving the ability of ground-based sim
James BelcAdvanced M (781) 890- jbelcher@infoscitex.com Sand ingestion into aircraft engines, includ
Jeremiah SManager, E(781) 890- jslade@infoscitex.com To provide the Navy with a successful me
Anna GaleaDirector, (781) 890- agalea@infoscitex.com Accurate orientation and position tracking
Geoff PorteProgram Di(212) 213- porter@eurasiagroup.net This project proposes to develop a rapid e
Prabhakar Sr. Scientis(404) 584- ptamirisa@excellatron.com The Lithium-oxygen electrochemical coup
Robert WoSenior Eng(781) 890- rwoodman@infoscitex.com Currently deployed defense space system
Jonathan PGroup Lead(781) 890- jportny@infoscitex.com The current fight helmet provides impact
Larry RoderPresident (215) 375- roderick@k-technology.com A new metal matrix composite material co
James CornCTO (781) 893- jcornie@mmccinc.com A new metal matrix composite material co
Upendra KSenior Vice(713) 842- marathi@plxpharma.com We have developed a novel class of phosp
George HaPresident (435) 654- gchansen@xmission.com A class of conformal coatings, composites
Gregory MMaterials (716) 853- gberube@nanodynamics.com Infrared obscurants are commonly used t
Caine FinneVP Fuel Cel(716) 880- cfinnerty@ndenergy.com Technology is rapidly advancing both in th
Andrew P Project Ma(716) 880- ahope@nanodynamics.com Infrared obscurants are commonly used t
Robert A Optical En (520) 626- rnorwood@optics.arizona.edu A waveguide optical isolator is proposed b
Yongming CCEO/Direct(484) 888- ycai@photo UNIV. OF PENNSYLVA(215) 898-9645 Photon-X, University of Pennsylvania (UP
Thomas Bro Chief Techn(858) 679- tom.brotherton@iac-online.com Safety incidents due to failure of rolling el
Joseph Bir Chief Techn(360) 694- joseph.birmingham@microsti.com DARPA is seeking an universal sample pre
Joel Bock Scientist (858) 679- joel.bock@iac-online.com Propulsion Health Management (PHM) of
John SlougDirector o (425) 319- sloughj@cUNIV. OF Catherine A(206) 616-0636 The Electrodeless Lorentz Force (ELF) Thru
Arkady Ba Optical En (520) 465- abablumian@yahoo.com The overall goal of the program is to deve
Wesley SheVP Produc (215) 658- sheridanw@gosage.com The proposed system is a wide field of vie
Ted SlusarcScientist II (609) 921- tslusarchyk@scitec.com A critical need for the ballistic missile defe
David PoppSenior Eng(858) 679- david.popp@iac-online.com Several long term vibration problems have
Michael B Chief Tech (512) 382- doerr@coherentlogix.com Coherent Logix, Incorporated (CLX) propo
Mark J ColaDirector o (505) 660- cola@beyond6-sigma.com Integrally Bladed Rotors – IBRs – are an im
Joseph ChiProject Ma(703) 683- joechiara UNIV. OF Eduardo Sa(407) 882-1325 The intent of the proposed research effor
Patrick JamVice Presi (608) 334- pijames@tesla.net Existing Core simulation models used for
John Cassi Metallurgi (205) 307- jcassimus@vistaeng.com It is proposed that a Phase I SBIR be cond
Heath Hof Associate P(814) 865- hofmann@e THE PENNSHelen Tyso(814) 863- ELECTRICI Combat units operating on foot in remote
Adel Chemaly (513) 985- adel.chemSANDIA NALynn J Was(505) 845- FSST ALTE Although numerical analysis applications
Eric Walters (765) 464- walters@pPURDUE UN Steven Pek(765) 494- power elecCatastrophic failures in aircraft electrical p
Luis Hernandez (703) 871- luis@gssllcGEORGIA IPaul Hart (404) 894- Prognosti Based on the research and analysis condu
Mariano Velez (573) 364- mvelez@mo TE K. Krishna (573) 341- OPTICAL T Mo-Sci Corporation and the Missouri Univ
Carol Cheung (781) 430- ccheung@iGEORGIA TJim Rehg (404) 894- AutomaticThe iRobot team proposes to develop a d
Richard MuProject Ma(631) 665- rmurrayopStub IGNITERS, The primary objective of this project is to
I.J. Won Chief Scien(919) 839- ijwon@geoStub ELECTROMA The goal of this project is to design, build,
Hongjun ( (Sr. Researc(301) 294- jli@i-a-i.c Stub handoff,ArThe multiplicity of existent wireless netwo
 Francesca Principal S (978) 689- fscire@psi Stub Antenna a In this Phase II SBIR Army Program, Physic
Reuben VaCEO (847) 265- Reuben.VaStub RADIO FREA compact, rugged, mobile, integrated au
Alicia Bor Director o (508) 655- alicia.borgman@tseboston.com ENCUMBRAN A wealth of studies involving the effects o
Robert WarProgram M(732) 673- rwarner@eStub RFID,SENS At the present time there is no system to
Ashok SoodPrincipal I (781) 503- aksood@ma Stub Infrared I Next generation EO/IR Nanosensors are n
Kurrt BaumPrincipal I (626) 334- fuoroche Stub CHEMICALImproved solid performance is needed to
Roy Nakagawa (626) 296- rnakagawa@alliancespacesystems.com Current science for Mars and lunar explor
Robert Finkelstein (301) 983- RobertFinkelstein@compuserve.com The purpose of the proposed project is to
Oleg Mukhanov (914) 592- mukhanov@hypres.com HYPRES is pleased to propose the develop
Bryan Ada Dr. (781) 418- badams@irMIT CSAIL Laureen Ho(617) 253- machine l The NOSTRA system monitors battery hea
Chris PersoMr. (256) 327- cpersons@digitalfusion.com MillimeterA full Stokes, passive MMW imaging polar
Richard MuMr. (631) 665- r_murray@omnitekpartners.com IGNITERS,IThe primary objective of this project is to
Dan KominDr. (540) 961- dkominsky@primephotonics.com Sensors,bl Prime Research, LC, in proposes to transiti
Brady ClapDr. (303) 261- bclapsaddle@tda.com Vector sur Civilian and military organizations through
Robert McCMr. (703) 365- robert.mccaig@assett.net LATER Later
the overall cost of each of the 20 million
jorr@abl.med.utah.edu () - ritical events by 60%.
John WhalManager/ (207) 474- harmonbrookfarm@hughes.net Commercial wild harvest of rainbow smel
Stefan Jeglinski (919) 489- jeglin@4pi.com The recent emergence of the Silicon Drift
Mark Munro (406) 522- munro@advr-inc.com This NIST Phase 1 SBIR effort will demons
Timothy S President (907) 357- tveenstra@atiak.com Airborne Technologies, Inc. Phase I effort
Thomas E Computer (S860) 464- tew@applmath.com People who work in the marine sciences fi
Jay Stockley (303) 604- jstockley@bnonlinear.com The proposed effort is to build a high reso
Robert Miles (440) 951- bobm@circuitequipment.com This SBIR deals with developing a comme
Evren Sirin (202) 408- evren@clarkparsia.com We propose to evaluate tree dominant se
Bruce GandScientist (303) 440- gandrud@dropletmeasurement.com Two, complementary techniques are prop
Marco FlagChief Engi (831) 384- mf@desertstar.com The SeaTagTM project proceeds in Phase
Shubo Datta (609) 434- sdatta@chipsat.com Conversion of highly stable optical clocks
Geoffrey Barrall (858) 228- gbarrall@electronicbio.com In order to realize robust, inexpensive and
Andrew Chepaitis (212) 327- ajc@elialife.com New innovative technology for the visuall
Siddarth Sundaresan (703) 996- sid@genesicsemi.com A novel chemical vapor deposition (CVD)
John A KosDirector, (781) 529- jkosek@ginerinc.com NOAA supports over 25,000 underwater d
Vincent M Director
K (410) 829- vince@gescience.com In our Phase I test, Green Eyes successfull
T. Martin SPrincipal S (858) 457- mikeporter@hlsresearch.com In recent years, there has been increasing
Charlie Danaher (303) 447- cdanaher@hpd-online.com Identify and study candidate architecture
Indu SaxenSenior Sci (424) 263- sbirproposals@intopsys.com Underwater monitoring systems are prese
Ian McComResearcher(808) 331- imccomas@kona-blue.com Further research is needed to define the c
Allan Smith (863) 588- allan.smith@masscal.com The work proposed will provide a demons
Daniel Kane (505) 401- djkane@mesaphotonics.com Modern supercontinuum (SC) light source
John Trenkle (510) 525- jmtrenkle@yahoo.com This proposal introduces the Detecting Int
Benaiah Schrag (508) 672- schrag@micromagnetics.com This SBIR project aims to develop a new c
Alison Brown (719) 481- abrown@navsys.com The 1588 Precision Time Protocol (PTP) pr
Stephen H CEO (207) 322- spage@oceanfarmtech.com Open-ocean finfish aquaculture presents
Stephen H CEO (207) 322- spage@oceanfarmtech.com Ocean Farm Technologies (OFT) proposes
Richard Hutchin (818) 880- rahutchin@opci.com Optical Physics Company is proposing a th
Jerome P FScientific (240) 320- jf-appltech@comcast.net Identification of particular fish species ba
Kurt Vogel (303) 444- kvogel@precisionphotonics.com VIPA etalons are simple, compact devices
James J StagSenior Scie(678) 384- jim.stagliano@pra-corp.com There is a strong correlation between clou
Ivan PopSteVice-Presi (413) 549- popstefanija@prosensing.com
James R CaPresident (508) 362- carswell@rmss.us
Graeme R A Senior Pro (970) 484- graeme.aggett@riverside.com
David Bromse (505) 984- dbomse@swsciences.com
Paul Todd Chief Scien(812) 923- ptodd@techshot.com
S. Sriram (614) 578- sri@srico.com
Robin Cantor (505) 424- rcantor@starcryo.com
W. Keith Manager, I(410) 273- keith.bowman@survice.com
Clayton J KSenior Eng(720) 494- ckostelecky@synkera.com
Stan Farrell (207) 933- sfarrell@textech.us
Philippe Bado (734) 528- pbado@translume.com
Cary Landis (304) 276- clandis@virtualglobal.com
Andrew Huntington (971) 233- andrewh@voxtel-inc.com
Justin Weller (315) 732- jweller@criticalimaging.net
Joanne H SPrincipal S (978) 663- shorter@aerodyne.com
LawrrenceDirector P (781) 935- Ldomash@agiltron.com
Barbara J CResearch Sc(386) 462- bcarter@biotech.uf.org
T G RobertChief Scient(802) 651- guy.avatar@verizon.net
George W JResearch Sc(713) 741- bill@biotexmedical.com
Paul W Wev President (309) 965- pwever@chipenergy.com
Sudipto M Director, (302) 999- smaiumdar@compactmenbrane.com
Lakshman B Senior Eng(949) 768- lbenedict@eerge.com
Kevin M SpSenior Scie(781) 769- spencer@eiclabs.com
Jason M Sto Senior Scie(303) 530- eltron@eltronresearch.com
James H Wh Catalysis (303) 530- eltron@eltronresearch.com
Robert KaisPresident (781) 938- rkaiser@entropicshstems.com
Owen HughPresident (530) 756- owen@eonresearch.com
Nuwan U Se Research Sc(814) 571- nus102@psu.edu
Dennis FitzOwner (951) 676- drfitz48@aol.com
Mourad Ma Project Ma(781) 529- mmanoukian@ginerinc.com
Glen J BastSenior Sci (424) 263- sbirproposals@intopsys.com
Jeffrey C APresident (781) 888- alexander.jeff@comcast.net
J R Kittrell President (413) 549- kseinc@aol.com
Domenic PPresident (906) 475- popkodc@aol.com
Paul K Liu President (412) 826- pliu@mediaandprocess.com
James C WiChief Execu(520) 574- jcwithers@mercorp.com
Michael C President (978) 952- mkimble@reactive-innovations.com
Andrew T HChief Execu(678) 287- dsmith@ngimat.com
Slawomir W Senior Scie(785) 537- slawek@nanmatinc.com
David GoorResearch Sc(479) 575- dgoorskey@nn-labs.com
Edward J SPresident/(615) 734- ejsommer@nrt-inc.com
Deyang HoDirector o (281) 980- dalianqlc@aol.com
Brian ElliotSenior Che(303) 940- belliott@tda.com
Lyle D BurnVP, R&D (918) 331- lburns@rtasys.com
David H ReProfessiona(918) 295- dreisdorph@thegreenteaminc.com
Martin C MOwner (907) 883- christokmarshall@hotmail.com
James C WiChief Execu(520) 574- jcwithers@mercorp.com
This proposal describes the development
The NOAA strategic vision is to help realiz
Water managers are increasingly recogniz
Southwest Sciences proposes developme
Even today as a highly technical and adva
This SBIR technology transfer program off
A key factor of international efforts to ide
The proposed Phase I SBIR research effort
A new, solid-state, carbon dioxide (CO2) s
New fire barrier methods are necessary to
Most commercial filters have significant lo
Under this proposal, Virtual Global, Inc. p
Voxtel proposes to develop fiber-coupled
The most practical arrangement for investi
The development of a sensitive, affordabl
American industry faces a costly problem
The overall goals of this Phase I grant are
This proposed project is for the experime
The focus of this research project is to de
New technologies require convincing evid
Phase II will build and evaluate pilot syste
This project describes a new technology i
This program will demonstrate the capabi
Eltron has a long history of developing ele
At the conclusion of Phase I, Eltron will ha
Successful completion of the program wil
The current U.S. Environmental Protection
Fuels derived from cellulosic biomass offe
The development of a no-maintenance, e
An accurate, portable and reliable ClO2 m
One innovative aspect of the proposed de
The design of the SP electrodes lends itse
The program entails the development of n
In our Phase II study Lesktech will design
Although water recycle and reuse is consi
All titanium is produced by the Kroll proce
The immediate application of this electro
Coal power accounts for 50 percent of the
NanoScale is uniquely qualified for the pr
The market for HB LEDs was $4.2 billion in
National Recovery Technologies is a majo
Preliminary experiment results show that
The commercial application is a new chem
It is recognized that the primary applicatio
The Green Team, Inc. (tGT) will conduct P
Thus, this project seeks to improve the em
All titanium is produced by the Kroll proce
Barbara J CResearch Sc(386) 418- bcarter@biotech.uf.org
Glenn J BasSenior Sci (424) 263- sbirproposals@intopsys.com
David H ReProfessiona(918) 295- dreisdorph@thegreenteaminc.com
Jason M Sto Senior Scie(303) 530- eltron@eltronresearch.com
George W JResearch Sc(713) 741- bill@biotexmedical.com
Owen HughPresident (530) 756- owen@eonresearch.com
Lakshman B Senior Eng(949) 768- lbenedict@eergc.com
Jeffrey C APresident (781) 888- alexander.jeff@comcast.net
Richard BreChief Execu(678) 287- rbreitkopf@ngimat.com
Lawrence Director P (781) 935- Ldomash@agiltron.com
Joanne H SPrincipal S (978) 663- shorter@aerodyne.com
James H Wh Catalysis (303) 530- eltron@eltronresearch.com
Nuwan U Se Research Sc(814) 571- nus102@psu.edu
Brian ElliotSenior Che(303) 940- belliott@tda.com
Edward J SPresident/(615) 734- ejsommer@nrt-inc.com
Martin C MOwner (907) 883- christokmarshall@hotmail.com
Paul W Wev President (309) 965- pwever@chipenergy.com
Michael C President (978) 952- mkimble@reactive-innovations.com
Kevin M SpSenior Scie(781) 769- spencer@eiclabs.com
Robert KaisPresident (781) 938- rkaiser@entropicsystems.com
Lyle D BurnVP, R&D (918) 331- 1burns@rtasys.com
Slawomir W Senior Scie(785) 537- slawek@nanmatinc.com
David GoorResearch Sc(479) 575- hchen@nn-labs.com
Domenic PPresident (906) 475- popkodc@aol.com
Sudipto M Director, (302) 999- smajumdar@compactmembrane.com
J. R KittrellPresident (413) 549- kseinc@aol.com
Mourad Ma Project Ma(781) 529- mmanoukian@ginerinc.com
Paul K Liu President (412) 826- pliu@mediaandprocess.com
Kenneth G Vice-Presi (505) 255- kenneth_blemel@mgtsciences.com
Carl Stern Senior Rese(505) 255- carl_stern@mgtsciences.com
Kenneth G Vice Presi (505) 255- kenneth_blemel@mgtsciences.com
Amaresh MPresident (978) 392- am@lindenphotonics.com
Amaresh MPresident (978) 392- am_lindenphotonics@msn.com
ChristopheControlls (520) 571- chornberg@arete.com
John DenniDirector, (707) 320- jdennison@arete.com
Ryan Epstein (303) 651- repstein@arete.com
Joseph TrisSenior Scie(520) 770- jtriscari@arete.com
Nicholas FlProgram M(818) 885- nfacco@arete.com
James MurrCorporate S(303) 651- jmurray@arete.com
John DerdePrincipal I (818) 885- jderderian@arete.com
Andrew Pau Advanced (520) 571- apaul@arete.com
Brad WallsSeniro Scie(520) 571- bwalls@arete.com
Andrew N Staff Scient(818) 885- ahock@arete.com
John DenniDirector, (707) 546- jdennison@arete.com
John EngelSenior Scie(520) 571- jengel@arete.com
James MurrCorporate S(303) 651- jmurray@arete.com
John R Enge Senior Scie(520) 571- jengel@arete.com
The overall goals of this Phase I grant are
One innovative aspect of the proposed de
The Green Team, Inc. (tGT) will conduct P
Eltron has a long history of developing ele
The focus of this research project is to de
The current U.S. Environmental Protection
This project describes a new technology i
The design of the SP electrodes lends itse
Coal power accounts for 50 percent of the
American industry faces a costly problem
The development of a sensitive, affordabl
At the conclusion of Phase I, Eltron will ha
Fuels derived from cellulosic biomass offe
The commercial application is a new chem
National Recovery Technologies is a majo
Thus, this project seeks to improve the em
New technologies require convincing evid
The immediate application of this electro
This program will demonstrate the capabi
Successful completion of the program wil
It is recognized that the primary applicatio
NanoScale is uniquely qualified for the pr
The market for HB LEDs was $4.2 billion in
In our Phase II study Lesktech will design
Phase II will build and evaluate pilot syste
The program entails the development of n
An accurate, portable and reliable ClO2 m
Although water recycle and reuse is consi
MSI develops and commercializes intellige
Management Sciences has developed a la
MSI manufactures multi-processor instrum
Optical fibers are extensively used in milit
Currently used wire harness technology c
Detection and countermeasure of Laser A
This project develops an innovative, enab
Technology research and development in
Areté Associates (Areté) proposes to deve
Areté proposes to create the software app
One of the major technical challenges of m
A principal limiter of airborne MAD system
The problem of sniper detection and neut
In recent years the number, capabilities, a
There is a demonstrated need for improve
Missile systems such as Hellfire provide o
Predetermined, hard-wired processing arc
Rapid and reliable identification or discrim
Areté Associates has created a software a
 Nicholas FlProject Ma(818) 885- nfacco@arete.com
John DuganCorporate (703) 413- jdugan@arete.com
Guy J J Far Corporate (703) 413- gfarruggia@arete.com
Paul W CarCorporate S(818) 885- carter@arete.com
J. Zandy WiSenior Scie(703) 413- zwilliams@arete.com
() -
Edward M Chief Tech (407) 737- eds@vcom3d.com
() -
Lynn Astle PhD (801) 367- LynnAstle Brigham YoJuliana Bo (801) 225-4823
emiskiel@ihsys.com () -
Berk GevecProject Le (518) 371- berk.geveci@kitware.com
William J Dr. (518) 371- will.schroeder@kitware.com
Eric CrossoDr. (408) 962- ecrosson@picarro.com
Eric R CrosDr (408) 962- ecrosson@picarro.com
Bauke HeeSenior Scie(503) 659- bheeg@metrolaserinc.com
Drew L'EspSenior Scie(949) 553- dlesperance@metrolaserinc.com
Vladimir B VP & Dir. o(949) 553- vmarkov@metrolaserinc.com
James KilpaSenior Scie(949) 553- jkilpatrick@metrolaserinc.com
Vladimir MV.P. & Dir (949) 553- vmarkov@metrolaserinc.com
Drew L'EspPrincipal I (949) 553- dlesperance@metrolaserinc.com
Thomas P JPrincipal I (949) 553- tjenkins@m Vanderbilt Not Availab(615) 322- Chemical; FTo address the need for non-intrusive sen
James D Tro Vice Presi (949) 553- jtrolinger WORCESTER Francois D(508) 831-5359
Vladimir MDirector of(949) 553- vmarkov@m UNIV. OF Evan Crieri(301) 405-6273
Bauke HeeSenior Scie(503) 659- bheeg@metrolaserinc.com
Drew L'EspSenior Scie(949) 553- jtrolinger@metrolaserinc.com
Drew L'EspSenior Scie(949) 553- dlesperance@metrolaserinc.com
Vladimir MDirector of(949) 553- vmarkov@metrolaserinc.com
Christina APrincipal I (949) 553- carnold@metrolaserinc.com
rbilhorn@directelectron.com () -
Sooha P LePresident/(908) 240- soohapark@hotmail.com
Sooha P Lechief softw(908) 240- soohapark@hotmail.com
Roger Cha President (215) 528- roger.chapman@cws-i.com
ELIJAH M BOLOTIN (206) 860- EBOLOTIN@PHARMAIN.COM
Jessica BraManager, I(703) 682- jessica.bradley@dac.us
Mike ColonSenior Eng(703) 414- mike.colony@dac.us
David FiskeMgr of Ba (703) 414- david.fiske@dac.us
Andy DavidSenior Eng(703) 414- andrew.david@dac.us
David FiskePrincipal I () - david.fisk Louisiana SNot Availab(225) 578-3386
Chris SmithSenior Eng(703) 682- chris.smith@dac.us
Dan SchrimSenior Eng(256) 895- dan.schrimpsher@dac.us
Chris SmithSenior Eng(703) 682- chris.smit MASSACHUS Leslie Pack(617) 258-9695
Peter DavidSenior Eng(703) 414- peter.david@dac.us
Mike ColonDeputy Dir(703) 414- mike.colony@dac.us
() -
Michael JoVP/CIO (405) 228- mike.johnson@anautics.com
Billy GastoPresident/(405) 228- billy.gaston@anautics.com
Daniel K Davies (719) 592- dan@ablelinktech.com
As adversarial submarines become quiete
Littoral METOC products are required for
Areté Associates’ is proposing to develop
In Phase II of this SBIR program, Areté Ass
Monitoring bathymetry changes in shippi
This project develops and evaluates a pro
For this Phase II SBIR project, Vcom3D wil
This project develops software for hand h
The Small
cts the Businessintegrity
functional Technology Transfer
of the sacculeR
ealth by developing better VEMP testing s
As numerical simulations have grown in s
Large-scale accelerator modeling is vital t
Scientists have reached a strong consensu
Methane (CH4), water vapor (H2O), and c
Two optical measurement techniques are
This Phase I SBIR proposal addresses an A
Reliable and operationally simple method
This proposal seeks to produce a unique i
Efficient laser beam delivery on a distant e
Testing FaciThis is a proposal to develop an electronic
In this Phase II proposal, MetroLaser and
Efficient laser beam delivery on a remote
This proposal outlines a plan to design, de
We propose to develop a Stereoscopic La
We propose to develop a high-speed digit
This project seeks to develop a unique ins
Optical; PhThis
m (on is the
a Phase
orderII of
SBIR proposal
3.5K to develop
x 4K pixels) and a
eins, enzymes, or viruses to pioneer new
The objective of this proposal is to demon
Voice transformation is altering one perso
The
entsuse of tactile
aren't displays
developed. Thisfor intra-squad
Phase I applic
product will contain an enzyme (lysostap
The asymmetric threat poses perhaps the
Today’s threats tend to maneuver in comm
Decisive Analytics proposes build a execu
Under this Phase II SBIR, the Decisive Ana
Our proposal and the Phase I work compl
A high-quality SIAP is the essential founda
We propose a “model-of-models” approa
Conventional statements of logic (e.g., sim
Despite significant research, engagement
The Global War on Terror (GWOT) has am
The Anautics CourseBook Project will add
The Global War on Terrorism is increasing
Many Department of Defense (DoD) weap
Develops and evaluates the Accessible Te
Steven E Stock (719) 592- steve@ablelinktech.com Demonstrates the technical merit and fea
Daniel K Davies (719) 592- dan@ablelinktech.com Develops and tests the Visual Media Liter
Daniel K Davies (719) 592- dan@ablelinktech.com Investigates the utility of Web-Voyagaer a
Peter Solomon (860) 528- peter.r.solomon@comcast.net There is a troubling decline in the numbe
Greg Seifert (763) 463- gseifert@ame-corp.com A wireless system to alert peope who are
Daniel Hedin (763) 463- dhedin@ame-corp.com A
wedevice whichlonger-term
will initiate performs optimal face reco
experiments
William R Kreitzer (217) 781- billkreitzer@advancedprairie.com meaningful results in Phase
Preliminary work at WSU has shown that II."
Craig S Frear (208) 413- csfrear@yahoo.com A completeddeveloped
capabilities prototypeunderof thethis moving
effortbaffl
w
Susan C Dunlap (650) 328- susancdunlap@hotmail.com respond to, and capitalize, on
utilizing PFC in their effluent treatment new marketsy
Bud G Harmon (636) 273- julydays@aol.com inexpensive feed source
handling efficiencies, andtoa livestock
comparative prods
Richard L Slocum (407) 468- rick@agristarts.com confirm the usefulness of this new techni
Corinna Lathan (301) 495- clathan@atinc.com A multi-modal
"Global demands computer interfacehave
for red snapper devicere
LeeAnn Applewhite (352) 376- aplsci@bellsouth.net Several DNA-based test formats have eme
Douglas G Managing (504) 837- douglas@beadfilters.com Commercial-scale marine aquaculture has
Walter A Zeltner (608) 345- walt@microporousoxides.com Recirculating
have implications systems are expected
for improving to play
abiotic st
Charles Moehs (206) 903- max.moehs@arcadiabio.com wheat and maize.
Friendland Lew (414) 736- lfriedla@gmail.com Service-learning is community service per
Lew Friedland (414) 736- lew.friedland@communityknowledebase.com This project assessment
preliminary is to developofYouth Map a soft
the feasibility o
Kimberly Kelly-Winte (865) 777- kwintenb@atmosphericglow.com bulb harvesting operation."
Jeff Baxter (870) 644- awargoiii@seark.net Profit margins in commercial catfish produ
Robert Seccomb (406) 541- rseccomb@beealert.blackfoot.net This project
and sum is aimed
statistics at helping
to identify protect
those SNPscra
Daniel B Weaver (936) 825- beebuzzboys@aol.com associated with mite resistance."
Millions of dollars are lost worldwide due
Guy Fromme (303) 939- gfromme@ball.com Phase I trials have shown that early detec
DEANNA J NELSON (919) 678- dnelson@biolinkonline.com Iron (Fe) deficiency
conditions on the final is the worldsgum
xanthan most pre
prop
I-Ching TanPresident (614) 761- bictang@sbcglobal.net feasibility of producing
health of forests, createxanthan gum from
a new resource fo
Masood Akhtar (608) 332- makhtar@biopulping.com and still produce a new and improved
benefits to be widely integrated into avian MD
David N Radin (870) 972- dradin@astate.edu populations.
carcasses to niche markets. All segments
Doyle E WiPresident (515) 233- dewilson@biotronics-inc.com benefit to be realized by the consumer.
Dianne Goodwin (612) 724- dianne@blueskydesigns.us Accessible
and enhance andquality
portable watercraft
of rural transfe
life while pro
Ahtasham Ashraf (608) 237- aashraf@centralsig.com crossing system and reducing
Phase II goal is to demonstrate economica community
Robyn A Foti (781) 899- rafoti@ceramem.com hydrophobic
and sum statistics PV membrane
to identifyfor a period
those SNPsoa
Christopher B Hoffma(781) 899- hoffmann@ceramem.com associated with mite resistance."
Christopher Camacho(212) 905- chrisc@childrensprogress.com The proposed
agencies. Phase research builds
I will adapt upon game
a video the w
Bryan C Rickertsen (402) 484- brickertsen@commgraphics.com of the project strategy."
This program introduces a membrane syst
Stuart NemChairman (302) 999- snemser@compactmembrane.com Phase II willCMS
In parallel, integrate commercial
has established membr
strong rel
Stuart Nemser (302) 999- snemser@compactmembrane.com Given platform technology and
evaluate an alternative out-of-season spa industrial
Robert Sahaghian (608) 215- robert_sahaghian@yahoo.com techniques.
() - Based on previous
Anticipated results research,
are fow cells this project
that cand
Peixuan Zhu (240) 453- pzhu@creatvmicrotech.com Further development can expand the num
William McCann (610) 783- info@dancingdots.com Evaluates
" and defines the Lime notation s
Daniel Car Founder &(229) 248- dcarraway@danimer.com Increased
" Achieve rapidsustainability
injectateofrates
farming and pl
to achieve
Leo D Pedersen (925) 820- dantec@att.net that make the process commercial viable
Dan Rooney (608) 442- dan.rooney@soiltopo.com Various methods
could provide newhave beenpotential
income developed foranfa
Michael J Blaylock (703) 961- blaylock@edenspace.com the Conservation Reserve Program."
application can be expanded to include ot
Lakshman Benedict (949) 768- lbenedict@eergc.com wastes)
consultants,in other
and areas of the country
entrepreneurs who arewhep
Chad B Roller (405) 307- cbroller@ekipstech.com and
BRD manure management
is not currently for and
available livestock."
none o
Gina L McMillen (405) 307- gmcmillen@ekipstech.com respiratory disease are capable of early de
 prototype unit will be fabricated and teste
Michael T CSensor/Ch(303) 530- eltron@eltronresearch.com cooperation
2. Commercial with USDAinterested
dairies ARS staff in in partici
Fayett
Frederick T O`Neill (206) 634- tim@compostsystems.com 3. ECS markets compost system to diary a
Ranjini Chatterjee (510) 732- rchatterjee@farasis.com The
Due global
to large issues of increasing
increase in the price petroleum
of oil, pr
Henry Liu (573) 442- fpc_liuh@yahoo.com The
mulches, and weed control disks canwill
success of the Phase I research be es
d
Perry Gardner (860) 824- pgardner06024@comcast.net transfer agreements and product
explore high-pressure steam reforming of licensin
John Reardon (515) 292- jreardon@frontlinebioenergy.com process grade
capabilities hydrogenunder
developed and other biofue
this effort w
Dmitry Varlyguin (814) 237- dmitry@gdacorp.com respond to, and capitalize, on
high-quality, high-value, widely recognize new market
Robert Cooper (808) 322- info@originalhawaiianchocolatefactory.com production.
method in collaboration with the Poultry
Scott A Callison (336) 406- sac@gtcallison.com University
Government of for
Georgia."
the detection and decont
David Schofield (843) 573- dschofield@guildassociates.com and offices.
be available to small farmers for packagin
Kushal Talukdar (508) 850- kushal@harrisacoustic.com farmers
marketing to product.
add valueThe to their
project products
will improan
Russ KremePresident (573) 659- russmfu@earthlink.net systems.
substantial increase in organic production
Jodi Lew-Smith (802) 472- jodi@highmowingseeds.com improved vegetableagricultural
such as monitoring varieties, and a signifi
resources
Robert L Crabtree (406) 556- crabtree@hyperspectives.net sources,
2. Tele-psychiatry portals to serve highcarb
and measuring sequestered ne
Jason Cafer (573) 445- painfullymidwestern@gmail.com mental health services
Corrine Vinopol (301) 942- corrine@idrt.com Develops a fully bioelectric , portable gest
Raymond Houghton (206) 344- raymond@inbios.com Aquaculture of shrimp
lines. Our success is a multi-billion
will enhance the poultr do
Hansong JiDirector o (301) 279- jinghs@ivausa.com poultry
by dyedproducts
road salt to American
that is already consumers.
sold to de
Johathon A von Fraun(410) 357- javf@comcast.net salted."
Matthew M Erdman (515) 294- merdman@iastate.edu There is a clear and
a photo-catalyst immediate need
semiconductor and thefor ima
Alan McMaster (419) 724- amcmaster@itfcoatings.com deposition of the films is integral
toward developing a commercial product to the p
Mohd A Abdullah (706) 542- mamir@uga.edu opportunities for Bt-based
representing savings to STSinsect controlo
(if adopted)
Agenor Mafra-Neto (951) 686- agenor1@iscatech.com previous
knowledge four years. will be widely disse
generated
Agenor Mafra-Neto (951) 686- president@iscatech.com the main grape
significantly, savinggrowing
$206regions
million of in the
fourea ye
Agenor Mafra-Neto (951) 686- president@iscatech.com the targeted 1,715,000 acres
thinner air and denser moisture levels. Troof cotton."
James L Ruhlman (787) 839- casitadriana@yahoo.com commercial
The objectivelevel below
of the Phase 2000 ft. altitude."
II proposal is to
Hai Yuan Principal I (808) 732- hyuan@konabaymarine.com Located in the State of Hawaii, Kona Bay w
Rik Lemoncello (541) 346- rik@coglink.com TV Assistance Program, a form of rehabilit
Lynn Fox (503) 725- foxl@ohsu.edu The Personal Accessresearch
A multidisciplinary Computer teamKey, a mod
will imp
Lilliana Jo President (207) 721- lillianagwi@juno.com Commercial
research will determine if the method is fi
applications are anticipated
Edward F Todd (662) 494- etodd@cpjvaccinator.com with researchers
properties, at the USDA-ARS
and quantify the production Poultryc
Brian Hennings (979) 693- brian.hennings@lynntech.com enhanced biofuel price point."
(Generally Regarded As Safe) by the FDA,
Adrian Denvir (979) 693- adrian.denvir@lynntech.com also environmentally
in groundwater in thebenign.
U.S. During the Pha
Anuncia Gonzalez-Mar (979) 693- anuncia.gonzalez-martin@lynntech.com will be developed
conclusions, Lynntechs and field-tested."
design and engine
Mark J Flu Research A(979) 693- mark.fusche@lynntech.com design, manufacture, and
operating conditions, determine test a fully-opti
process f
Yu Huang (650) 543- ihuang@mtrinc.com development in a Phase II project."
Donald Wright (512) 218- don.wright@mdgc.com Hundreds
MMP will work of volatile
with achemicals
local group have to been
comp
Robert Kearns (406) 599- kearns@3rivers.net Phase 1 research will result in
against rabies. A key concern to be addres an energy e
Jeffrey A MSr. Vice Pre(610) 738- jmattis@mtarget.com recombinant virus in target and non-targe
Sherman B Woody (617) 576- woody@molysym.com Model perception and understanding the
Keith Donaldson (617) 576- keith.donaldson@molysym.com The
otherpurpose of this project
farms, increase sales of is to produce
market-size
William Mook (207) 563- mooksea@tidewater.net microalgae to finfish and shrimp farms.
Harold Sears (801) 326- harold@utaharm.com Develops
farmers. Itaissmall, waterproof,
estimated that 2000 Warless
dairyEM fa
Keith E Bowers (206) 725- keithbowers@yahoo.com characteristics that suit them
commercial use in current pulp preparatio to use of th
George Grozdits (318) 436- grozdits@latech.edu bonding and stronger
biocide release to desiredpaper."levels and meth
Sang Beom Lee (412) 770- sblee@nanodynamics.com into MDF will be developed."
SOFC system would provide a renewable,
Paul Matter (614) 842- p.matter@nextechmaterials.com technology naturally suited to distributed
 community to utilize nitrogenous inputs m
Wilbur H CPresident (906) 296- bill@nitrate.com well
elementas the
of rural environment.total system
a patent-pending
Ronny Horax (479) 571- rhorax@virtual-incubation.com market value products from HDRB.
Susan Palsbo (541) 505- obslap.research@comcast.net A prototype
Objective special
3. An education
assessment of interventio
the practic
Keith E FlePrincipal I (503) 557- oresoil@aol.com This research will involve greenhouse and
Lawrence M Dr. (973) 983-0813 The proposed and
manufacturer buried innerduct/duct
consumer preferences. netw
David L Putnam (425) 497- putnam@photonicsystems.com will find applications in food and pharmac
Irene Schipper (516) 668- schipper@pagefip.com A high-speed, automatic book scanner to
Paul Stockton (701) 786- sensit@polarcomm.com This study will determine the feasibility an
Louis Albright (607) 539- lda1@cornell.edu This project
survival ratesisoftoour
develop
oysters a marketable
and musselen cr
Christopher V Davis (207) 832- cdavis@midcoast.com develop new management techniques.
gilt replacement systems and work to furt
Stephen Webel (217) 236- steve.webel@jbsunited.com applicator.
We propose a Cooperative Research and D
Daniel W President (865) 385- mcdonalddw@phenotypescreening.com There
of the remain
monitorunanswered
would be inscientific
establishing questi
an
James A Kane (781) 449- jkane@polestartech.com degreening of harvested fruits and vegeta
Jeanne Finstein (304) 242- jfinstein@polyhedronlearning.com Polyhedron Learning Media,
biofuel will significantly reduce Inc.,the Wheelin
enviro
Benjamin Bikson (781) 391- bbikson@porogen.com US economy on the foreign
discussion with several dairy equipment moil.
Wai T Law President (856) 231- wailaw@portascience.com market is fortysuperior
competitively million dollars.
silver zeolite activa
George Sadler (708) 403- sadler@proveitpdq.com working procedures for applying
of the field-ready multi-array future ac
prototype d
Finny Mathew (734) 786- finny@rapidbiosense.com adaptable for human diagnostics
continuous operations that can compete using ap
Brian J Elliott (303) 940- belliott@tda.com Nations dependence on foreign oil.
Martin Noretsky (703) 820- contact_us@readysetsign.com A translation software program for hand-h
Hyung Park (847) 853- hyungsoon.park@gmail.com Develops a low-cost and portable rehabili
William L Petersen (608) 229- williamljpt@aol.com The objective
completion ofof this
this proposal
project will isresult
to develo
in a 1
T. S Kennedy (207) 882- kennedy@rynel.com commercial forestry efforts, greenhouses
effectively treat colonies for Varroa infesta
Gordon Wardell (520) 670- gordyaw@aol.com and no new equipment needed.
Stanley P DPresident (480) 820-2032 In
andPhase I of this SBIR
test marketing. Thisproject the propose
is achieved by em
Patricia PinPresident (207) 321- ppinto@maine.rr.com partnership
The first objective in this research is toben
that also offers important ide
Robert Mansfield, Jr. (216) 675-2314 At the conclusion of this project, we expe
Sales C Gregory (612) 721- gsales@sewardinc.com The First 4,000 Words project will develop
Greg Sales (612) 721- gsales@sewardinc.com The First 4000will
formulations Words project will
be evaluated in andevelop
in viv
Bruce Van Der Kamp (303) 256- bvk@comcast.net at various times post-application.
outbuildings and homes, especially in rura
Heather H Grichnik (309) 682- hgrichnik@smartenergyltd.us energy
water we expense
drink. Itandwillalso reducewildlife
improve fossil fue
ha
Sandra M King (406) 652- sandy@smkplants.com species.
Phase I will investigate the feasibility of th
Craig Huhta (858) 546- chuhta@sontek.com The Irrigation
In vivo productionTraining and Research
technology Cente
is a well-su
Walker L Tedders (478) 988- sei@alltel.net This research will lead to development of
Edmondson Shawn (435) 753- sedmondson@spectrumedu.com The purpose of this project is to develop a
Shawn Edmondson (435) 753- sedmondson@spectrumedu.com The purpose
for tribal of this
council, project
board is to develop
member and empa
Erich Longie (701) 351- ericstev@spiritlakeconsulting.com intervention mandated for
The applicant, Staron LLC, has developedboard membe
Richard M Poche (970) 568- richardp@genesislabs.com The superior
interest. Sinceofallthe two products
formulation will be c
ingredients
Robert ColD (608) 826- colema95@msu.edu priority,
ocean farming is growing rapidly. ItEnergy,
Alternate and Renewable will al
Frank J OBrien (714) 730- fjobrien@cox.net shop for mariculture consultation
customers will be edible oil process equip through
Pu Zhang Research Sc(734) 213- pzhang@tjtechnologies.com companies.
Kevin Chugh (716) 830- chugh@tactustech.com The Tactus
security, Immersive Learning
participatory government Environme
comm
Ardon T Morse (605) 352- tmorse@clawsco.com gathering.
Thomas Bourne (585) 202- tbourne@nextekgbl.com Terrenew has discovered that manures, a
Mark Nitzberg (617) 407- nitzberg@blindsight.com Determination
If both objectives of the
are user interface
successful, requi
it will ind
James Parsons (253) 863- parsons@troutlodge.com likely and lead directly to Phase
HIPAA compliant method for transmitting II researc
Paul Staman (319) 622- pstaman@tripletailventures.com existing, often disparate systems.

Mark H Greenwood (435) 881- mhg1983@gmail.com
John FallonVP Enginee(617) 491-0407
Vito G DelVecchio (570) 281- vdelvecchio@vitalprobes.com
David Morris (212) 633- dcmorris@ltgspeed.com
Michael Dziewatkoski(937) 767- mdziewatkoski@ysi.com
David B Anderson (970) 663- andersondavidb@comcast.net
Matthew Norconk (517) 353- norconkm@msu.edu
Brian L BurSenior Scie(510) 483- bures@aasc.net
Rick RusselDirector o (801) 377- rrussell@accessdata.com
Mark S Bow Director o (425) 482- mark.bowers@aculight.com
Melvin A PPresident (650) 598- melpie@adelphitech.com
Sebastian Senior Sys (410) 872- spascarelle@md.aacisd.com
Eric JohnsoVP of Rese(607) 533- eric.johnson@adc9001.com
Eric P RubeSenior Phys(860) 528- ericr@AFRinc.com
Gary D HavPresident (763) 463- ghavey@ame-corp.com
Joda WormPrincipal S (978) 663- jody@aerodyne.com
Godfrey Vas Chief Tech (631) 424- gvassallo@afcosystems.com
Ben BavariPresident (949) 644- ben.bavarian@afisandbiometrics.com
Thomas Cur Sr. Enginee(781) 935- tcurl@agiltron.com
Bill CardosVP of Tech(760) 752- bcardoso@aguilatech.com
Tia Gao President (650) 799- tiagao@gmail.com
GERALD ENPRESIDENT(617) 668- GENTINE@RMDINC.COM
James ChrisGroup Lead(617) 668- JChristian@rmdinc.com
Jaroslav GlSenior Scie(617) 668- JGlodo@RMDInc.com
Richard L FVice Presi (512) 339- dfink@appliednanotech.net
Richard L FVice Presi (512) 339- dfink@appliednanotech.net
John Wu ComputerSc (952) 829- jwu@atcorUniversity of Minnes () -
Elena BekyDr. (951) 682- bekyarova@carbonsolution.com
Charles J J Dr. (734) 668- cjacobus@cybernet.com
Robert F RResearch a(703) 961- rriemenschneider@crucialsecurity.com
Dana S AleVP Systems(732) 203- dana@daxtechnologies.com
Mark WebbStaff Soft (315) 838- mark@dolphtech.com
Christopher Jordan (703) 728- cjordan@endeavorsystems.com
Martin A MPresident (480) 460- Martin.Martinez@ESACORP.com
Robert M KPrincipal I (630) 293- bobk@epsilonlambda.com
Jeffrey M GPrincipal I (540) 769- submissions@lunainnovations.com
Russel G S Technical D(510) 523- hescohq@aol.com
C. ChristopSenior Scie(540) 639- cklepper@hytechresearch.com
James E DzSenior Pro (585) 424- jim.dzakowic@impact-tek.com
Stephen BuDr. (781) 246- sbunker@implantsciences.com
Roger Xu Director (301) 294- hgxu@i-a-i.com
Dan Xiang Research E(301) 294- dxiang@i-a-i.com
Roger Xu Director (301) 294- hgxu@i-a-i.com
Behzad Mos CEO/CTO (408) 565- bm@ifos.com
Michael ThDirector of(212) 809- mthieme@biometricgroup.com
Rick Dove Vice Presi (505) 586- rick.dove@kennentech.com
William A President (443) 283- waa@komoku.com
This small business innovative research pr
The purpose for this proposal is to obtain
In
Thethis Phase IIofwe
objective willproposal
this developisato work
demonzon
In
thethis Phase
Wind Fin,I farms
proposal
andthe feasibility
ranches couldofno p
enough wind energy to sell to utilities,
near a body of environmental water. In la fos
deployment in both fresh and saltwater e
Over the past
successful Phase15 years the incidence
II prototype has been of m in
relatively inexpensive addition to the safe
Alameda Applied Sciences Corp proposes
Increasing complexity of encryption used
Aculight, teamed with Lockheed Martin M
A pulsed neutron generator is proposed fo
A layered approach to Maritime Domain A
The Jaws-Of-Life is a hydraulic rescue tool
Radiological sources are in everyday use i
Lightweight portable biometrics screening
Aerodyne Research, Inc. proposes to desi
The primaryBenefits
Anticipated objectiveand of this project isApp
Commercial to
The
The proposed
objective of middleware
this effort product will ad
is to design, co
Since this Advanced Sample Collection Sy
The improved surveillance of radioactive
The recent wave of mass casualties plagu
Spread of the weapons of mass destructio
The use and applications of radiological so
Proliferation of weapons of mass destructi
The Domestic Nuclear Detection Office (D
The aim of this SBIR program is to develop
The Department of Homeland Security an
We propose to develop a novel class of se
Cybernet Systems is developing a novel, n
This proposal describes a system that wou
The speed at which an attack is detected
This effort proposes to design, develop an
Inline Botnet Extraction And Response, iB
Engineering Science Analysis Corporation
Commercial applications beyond that defi
Luna Innovations Incorporated will develo
We propose to build an Intensity-Modulat
The main objective of this DHS SBIR proje
Impact Technologies, in collaboration with
Trace chemical sampling is most effective
Intelligent Automation, Inc. (IAI) proposes
We envision that the proposed eye-safe L
Industrial control systems (ICSs) are crucia
Fires in tunnels, whether resulting from c
Commercial applications include border s
The primary objective of this project is to
The effectiveness of any critical infrastruc
Jason M DoPresident (520) 743- jason.douglas@latitudeengineering.com Commercial applications include upgrade
Yong Jin LeCTO and G(650) 533- lee@linearesearch.com The sensor system will be designed to be
Brian HennResearch Sc(979) 693- brian.hennings.@lynntech.com Recent trends in law enforcement clearly
Bikas VaidyResearch Sc(979) 693- bikas.vaidya@lynntech.com The transportation system is an attractive
Tony RagucSr. Researc(979) 693- tony.ragucci@lynntech.com Koopman search theory is built on the co
Marthinus CEO (781) 306- tienie@mide.com Midé, along with ballistics and fire
Alper Cagl Principal S (781) 839- acaglayan Sandia NatKevin Robb(505) 844-0747 In Phase II, we propose to develop a full-s
Jeffrey C BPresident (785) 537- jcblackwell@cox.net This proposal is for the design and develo
Michael A Senior Sof (626) 578- gibson@nextdimensiontech.com Reliable identification of chemical hazards
William RoPresident (626) 578- royea@nextdimensiontech.com The release of hazardous chemical vapors
Paul L WhitPresident (508) 347- pwhite@novascientific.com NOVA proposes development of a novel c
Jin Luo Chief Execu(607) 233- jluo@NSCTek.com This proposal
easier addresses
to fabricate sensorthe need
suites hasspecifie
the d
Randy PaffProgram Di(970) 461- rpaffenroth@numerica.us lighter, more robust equipment into the h
David Siu Electrical (808) 531- dsiu@oceanit.com Our vision for this product is that it will be
Stephen KoSr. Project (978) 263- korbly@passportsystems.com Electron accelerators that produce contin
Keehoon KGroup Leade (310) 320- sutama@poc.com To reduce the amount of radioactive mate
Ranjit Pra Vice Presi (310) 320- sutama@poc.com To address the need for combined vapor a
Eric Gans Research Sc(310) 320- sutama@poc.com The development of the NITSEW techolog
Alexander Group Lea (310) 320- sutama@poc.com To address the HSARPA need for remote d
Yunlu Zou Director (310) 320- sutama@poc.com To address the HSARPA need for an innov
David ZimdManager, T(734) 864- dzimdars@picometrix.com We propose a Phase II project to develop
Robert MatPresident (858) 373- robm@quasarusa.com The system will perform real-time ECG mo
Stephen T Principal S (760) 268- STHOBSON@SEACOASTSCIENCE.COM Seacoast Science, Inc. (SCS) proposes the
Curt Bilby President (512) 459- curt.bilby@seahawkbio.com Since 9/11, a distinct probability exists tha
Walter J ScLead Biome(719) 265- wscheirer@securics.com A second important and unique, aspect o
Bruce WillnSenior Eng(732) 302- bwillner@structuredmaterials.com SMI proposes developing a portable conti
Owen McCu Principal I (860) 326- mccusker@University Dr. Aggelos(860) 486-3719 This Phase
In this PhaseII effort
I SBIR will develop
project, a function
Synkera propo
Rikard A WSenior Scie(720) 494- rwind@synkera.com Our solid-state neutron detectors are exp
Pratik GuptPrincipal I (240) 790- guptap@technosci.com Techno-Sciences Inc. plans to develop spe
Richard E CSenior Ana(805) 968- rcagley@toyon.com Just as WiFi has become the de facto stan
Ronald W Technical (518) 370- rgamache@transtechsys.com Orphaned radioactive sources are a world
Miguel A CPresident (512) 215- mcardoza@tridentresearch.com At present, the field of mobile biometric s
John Lock Principal I (978) 250- jlock@tritonsystems.com Triton Systems, Inc. proposes a Secure Wr
Ted HockeyVice Presi (703) 742- mschor@alum.mit.edu This SBIR focuses primarily on monitoring
Jacob YadeCEO & EVP,(310) 473- jacob@utopiacompression.com Phase-I effort demonstrates feasibility of
Nithya Ra Lead Electi(817) 872- nithya.ramaswami@williams-pyro.com Williams-Pyro,
In Phase I of thisInc. proposes
project to develop
we focus on devea
Adel GhanPresident (925) 736- adel@zontrak.com Government agencies and the private sec
Arel WeisbProgram M(718) 608- aweisberg@er-co.com Energy Research Company (ERCo) and the
Jeremiah RSenior Eng(781) 890- jslade@infoscitex.com Stretch wrap film is increasingly being use
SCOTT C CORBETT (978) 646- SCORBETT@ABIOMED.COM DESCRIPTION (provided by applicant): The
B Robert () - N/A
n independent manner. This is relevant to
DANIEL K DAVIES (719) 592- DAN@ABLELINKTECH.COM hers to meet these transportation needs.
DEAN O KUETHE (505) 244- dkuethe@nNEW MEXICO RESONANCE DESCRIPTION (provided by applicant): We
RICHARD C GOLDSWO(812) 333- rick@academicedge.com DESCRIPTION (provided by applicant): Pre
Pothukuchy Arti () - N/A
ANDREW D ELLINGTO(512) 232- andy.ellin UNIVERSITY OF TEXAS AT AUSTIN DESCRIPTION (provided by applicant): Exp
TODD HARGRODER (210) 341- todd@adirides.com DESCRIPTION (provided by applicant): We
WILLIAM M LINDSTR () - DESCRIPTION (provided by applicant): The
LARS VILHUBER (607) 330- LARS.VIL CORNELL UNIVERSITY DESCRIPTION (provided by applicant): The
CHARLES D EMERY (206) 832- cemery@acoustxcorp.com DESCRIPTION (provided by applicant): Pro
DAVID W LEUNG (206) 812- DWLEUNG@ACUCELA.COM DESCRIPTION (provided by applicant): Age
RAYMOND D PRICE (206) 853- raymond.price@acucela.com DESCRIPTION (provided by applicant): The
MARK P BENDETT () - mark.bendNORTHWESTERN UNIVERSITY DESCRIPTION (provided by applicant): Ne
THOMAS E MACURDY(650) 558- tmac@acum SPHERE INSTITUTE DESCRIPTION (provided by applicant): Thi
THOMAS E MACURDY(650) 558- tmac@acum SPHERE INSTITUTE DESCRIPTION (provided by applicant): Thi
XICHUN ZHOU (303) 792- xichunz@adatech.com DESCRIPTION (provided by applicant): Car
XICHUN ZHOU (303) 792- xichunz@adatech.com DESCRIPTION (provided by applicant): Gly
Zhou Xichun () - N/A
BRADLEY D VEATCH (303) 792- BRAD.VEATCH@ADATECH.COM DESCRIPTION (provided by applicant): Co
JAYSON M RIEGER (434) 951- JRIEGER@ADENRX.COM DESCRIPTION (provided by applicant): Sel
JERRY KNOBELOCH () - DESCRIPTION (provided by applicant): The
VLADIMIR A KARGINO(703) 622- vak@innovbio.com DESCRIPTION (provided by applicant): The
CHRIS BERKA (760) 720- chris@b-alert.com DESCRIPTION (provided by applicant): Al
DANIEL J LEVENDOWS(760) 720- dan@b-alert.com DESCRIPTION (provided by applicant): Ob
ANJA K METZGER (651) 226- ametzger@advancedcirculatory.com DESCRIPTION (provided by applicant): Intr
VAMSEE K PAMULA (919) 287- vkp@liquid-logic.com DESCRIPTION (provided by applicant):
KEVIN M KRAMER (763) 463- kkramer@ame-corp.com DESCRIPTION (provided by applicant): Thi
GARY D HAVEY (763) 463- GHAVEY@AME-CORP.COM DESCRIPTION (provided by applicant): As
DANIEL S HEDIN (763) 463- DHEDIN@AME-CORP.COM DESCRIPTION (provided by applicant): Ad
DANIEL S HEDIN (763) 463- DHEDIN@AME-CORP.COM DESCRIPTION (provided by applicant): Ad
GARY D HAVEY (763) 463- GHAVEY@AME-CORP.COM DESCRIPTION (provided by applicant): Thi
PAUL L GIBSON (763) 463- PGIBSON@AME-CORP.COM DESCRIPTION (provided by applicant): Ad
DANIEL S HEDIN (763) 463- DHEDIN@AME-CORP.COM DESCRIPTION (provided by applicant): Ad
GREGORY J SEIFERT (612) 452- GSEIFERT@AME-CORP.COM DESCRIPTION (provided by applicant): Ad
PAUL L GIBSON (763) 463- PGIBSON@AME-CORP.COM DESCRIPTION (provided by applicant): A n
GINETTE SERRERO (410) 884- gserrero@agrx.net DESCRIPTION (provided by applicant): Bre
WILLIAM M JAMES (301) 435- BJAMES@2020GENE.COM DESCRIPTION (provided by applicant): We
NADA H KHATTAR (240) 453- nkhattar@2020gene.com DESCRIPTION
the capability (provided
to performby3Dapplicant):
perfusionApim
DAVID A FEINBERG (707) 829- DAVID.FEINBERG@ADVANCEDMRI.COM ve measures of blood perfusion will be us
Bochkariov Dmitry () - N/A
DOUGLAS J JOLLY (760) 943- djolly@advantagene.com First generationlost
y of treatment, non-replicative
productivityadenovira
and comp
ESTUARDO AGUILAR (617) 916- EAGUILAR@ADVANTAGENE.COM improve the outcome for patients with in
ESTUARDO AGUILAR (617) 916- eaguilar@advantagene.com DESCRIPTION (provided by applicant): Ma
JOANNE H SHORTER (978) 663- SHORTER@AERODYNE.COM DESCRIPTION (provided by applicant): The
BRIAN N HANSEN (303) 651- aerophase@hotmail.com DESCRIPTION (provided by applicant): Ast
BROOKS M HYBERTSO(303) 651- brooks.hybertson@uchsc.edu DESCRIPTION (provided by applicant): Ma
LILLIAN W CHIANG (734) 249- Lillian@AestusTx.com DESCRIPTION (provided by applicant): Mo
JIDONG FANG (717) 531- JFANG@PSPENN STATE UNIV HERSHEY MED CT DESCRIPTION (provided by applicant): 6. P
XINMIN S XIE (650) 784- simonxie@afasci.com DESCRIPTION (provided by applicant): Mil
PAUL T HAMILTON (919) 597- PHAMILTON@AFFINERGY.COM DESCRIPTION (provided by applicant): Ma
PAUL T HAMILTON (919) 597- PHAMILTON@AFFINERGY.COM DESCRIPTION (provided by applicant): Infe
HANNE GRON (919) 597- hgron@affinergy.com DESCRIPTION (provided by applicant): Acc
BENJAMIN M BUEHRE(919) 433- bbuehrer@affinergy.com DESCRIPTION (provided by applicant): Ap
SUNIL SAXENA (540) 882- ssaxena@aframedigital.com DESCRIPTION (provided by applicant): Thi
 to obtain a go-ahead to initiate clinical Ph
ATUL VARADHACHARY(713) 552- AVARADHACHARY@AGENNIX.COM y and straightforward path.
ARTHUR A DECARLO (205) 307- adecarlo@agentabiotechnologies.com DESCRIPTION (provided by applicant): The
ARTHUR A DECARLO (205) 307- adecarlo@agentabiotechnologies.com DESCRIPTION (provided by applicant): The
ALEXANDER REPENNI(303) 530- ALEXANDER@AGENTSHEETS.COM DESCRIPTION (provided by applicant): Sci
BIKASH SABATA (703) 236- bikash@aginova.com DESCRIPTION (provided by applicant): Env
H T BUNNELL (302) 651- bunnell@asA.I. DUPONT HOSPITAL FOR CHILD DESCRIPTION (provided by applicant): Thi
KEVIN CHEN (760) 752- kchen@aguilatech.com Not avaiable.
JANET E YANCEYWRO(207) 329- jwrona@suscom-maine.net DESCRIPTION (provided by applicant): AIK
CAL T COLLINS (617) 621- CCOLLINS@akazaresearch.com DESCRIPTION (provided by applicant): We
YOURONG FU (765) 464- YF@AKINAINC.COM DESCRIPTION (provided by applicant): The
DARRELL P CHANDLER(734) 428- dchandler@akonni.com DESCRIPTION (provided by applicant): The
DARRELL P CHANDLER(734) 428- dchandler@akonni.com DESCRIPTION (provided by applicant): Inf
ALAN M KRIEGSTEIN (516) 997- alank@alascience.com DESCRIPTION (provided by applicant): Hig
WILLIAM LAWRENCE (617) 668- WLawrence@RMDInc.com DESCRIPTION (provided by applicant): Titl
WILLIAM LAWRENCE (617) 668- WLawrence@RMDInc.com DESCRIPTION (provided by applicant): Ov
VIVEK V NAGARKAR (617) 668- VNAGARKAR@RMDINC.COM DESCRIPTION (provided by applicant): Rec
JAROSLAW GLODO (617) 668- JGLODO@RMDINC.COM DESCRIPTION (provided by applicant): Rec
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IRINA SHESTAKOVA (617) 668-6929 DESCRIPTION (provided by applicant): Info
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Wang Jiwu () - N/A
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can identify and remove Thet
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DAVID E SMITH () - DESCRIPTION (provided by applicant): Rh
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Levine Robert () - N/A
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Soscia Anthony () - N/A
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a wide variety(provided by disabilities,
of different applicant): The
inc
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rocedure prior(provided by applicant):
to transport BCR
for slaughter.
XIAOLI SU (479) 571- XIAOLI.SU@BIODETECTION-INSTRUMENTS.COM mutation of pathogenic AI viruses. The de
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Shugui Frank () - N/A
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nningavaiable.
new research. In the field of substa
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DONALD R KIRSCH (781) 938- DKIRSCH@CAMBRIABIO.COM DESCRIPTION (provided
cancer, pulmonary, by and
cardiac applicant):
vascularPar
d
RICHARD M LEVENSO(781) 935- RLEVENSON@CRI-INC.COM ctions.
zed sample handling protocols to retainco
Finally, easy-to-use software for p
RICHARD M LEVENSO(781) 935- RLEVENSON@CRI-INC.COM onitoring of response, and clinical practice
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MEGHAN COULEHAN(919) 960- COULEHAN@CLINICALTOOLS.COM DESCRIPTION
ies of medical (provided by applicant):
students and PRO
prepare them
T B TANNER (919) 960- TANNER@CLINICALTOOLS.COM isorders. The skills learned can also be mo
T B TANNER (919) 960- tanner@clinicaltools.com Not avaiable.
KARL WILKENS (440) 333- kwilkens@CASE WESTERN RESERVE UNIVERSITY DESCRIPTION (provided by applicant): Ov
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ERIC J BECKMAN (412) 231- ebeckman@coheramed.com DESCRIPTION (provided by applicant): The
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Evenson Paul () - N/A
STUART NEMSER (302) 999- stuart.nemser@compactmembrane.com DESCRIPTION (provided
an average 3.21 by applicant):
log10 depletion In P
of conta
ARFAAN RAMPERSAU(614) 485- ARFAAN@COLUMBUSNANOWORKS.COM e to sample.
NICHOLAS CAIRNS (650) 969- nick@combinix.com DESCRIPTION (provided by applicant): In d
Evenson Paul () - N/A
formation about the molecular mechanism
DANIEL R RHODES (734) 904- DRHODES@COMPENDIABIO.COM development companies, with a goal of o
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TIMOTHY MULONE (214) 343- tmulone@sbcglobal.net DESCRIPTION (provided
raphic technique by applicant):
that is superior Eve
to conve
CHAMEI TANG (301) 983- CMTANG@CREATVMICROTECH.COM mography system makers and users. The i
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CONSTANTIA PETROU() - DESCRIPTION (provided by applicant): Thi
ERIC C HARTMAN (859) 879- hartman@customKYnetics.com DESCRIPTION (provided
ublic health through by applicant):
development of anAm
e
ERIC C HARTMAN (859) 879- HARTMAN@CUSTOMKYNETICS.COM adriceps strengthening has been shown to
LEONARD W WINCHES (757) 872- lww@cwoptics.com DESCRIPTION (provided by applicant): Thi
Ho Vincent () - N/A
GARY R BRIGHT (858) 450- gbright@cyntellect.com DESCRIPTION
nsible for more(provided
than 1.5 by applicant):
million Du
fractures
JONATHAN KAUFMAN(212) 260- JJKAUFMAN@CYBERLOGIC.ORG ed research should enable bone testing to
LISA E FREED (617) 253- lfreed@miMASSACHUSETTS INSTITUTE OF TEC DESCRIPTION (provided by applicant): De
TIMOTHY J HAGGERTY(978) 232- thaggerty@cytocure.com DESCRIPTION (provided by applicant): The
LANE R BROSTROM () - DESCRIPTION (provided by applicant): We
JOHN K FRASER (858) 458- JFRASER@MACROPORE.COM DESCRIPTION (provided by applicant): Cel
RONALD W PETERSON(267) 499- rwp.cso@gmail.com DESCRIPTION (provided by applicant): Bio
CYNTHIA D BAKER (301) 565- CBAKER@DANYA.COM DESCRIPTION (provided by applicant): The
SALVATORE V LIBRETT(301) 565- SLIBRETTO@DANYA.COM DESCRIPTION (provided by applicant): The
SALVATORE V LIBRETT(301) 565- SLIBRETTO@DANYA.COM DESCRIPTION (provided by applicant): Tric
KAREN M GAVINEVAN(240) 645- kgavin-evans@danya.com DESCRIPTION (provided by applicant): The
Gavin Karen () - N/A
CYNTHIA D BAKER (301) 565- CBAKER@DANYA.COM DESCRIPTION (provided by applicant): The
Libretto Salvatore () - N/A
Wong Henry () - N/A
EDWARD C CHAO (425) 591- ECHAO@DATANUMERICA.COM DESCRIPTION (provided by applicant): Mu
EDWARD C CHAO (425) 591- ECHAO@DATANUMERICA.COM Not avaiable.
KEVIN F DAWKINS (914) 478- KEVIN@DAWKINS.TV DESCRIPTION (provided by applicant): Ge
KEVIN F DAWKINS (914) 478- KEVIN@DAWKINS.TV DESCRIPTION (provided by applicant): A d
CYNTHIA D BAKER (301) 565- CBAKER@DANYA.COM DESCRIPTION (provided by applicant): In t
LEE R MORGAN (504) 583- lrm1579@aol.com DESCRIPTION (provided by applicant): 7-b
Roy Lee () - N/A
CATHERINE M HARRIS(505) 867- CMHARRIS@UNM.EDU DESCRIPTION (provided by applicant): De
SUSAN P HAYNIE () - shaynie@geodemo.com DESCRIPTION (provided by applicant): Sm
STEPHEN K HARREL (214) 350- skh1@airmail.net DESCRIPTION (provided by applicant): Thi
JACK W DRESSER (541) 484- JDRESSER@ORI.ORG DESCRIPTION (provided by applicant): Res
HERBERT H SEVERSON (541) 345- HERB@DESCHUTESRESEARCH.COM DESCRIPTION (provided by applicant): Ora
DAVID H PEYTON (503) 725- PEYTOND@PORTLAND STATE UNIVERSITY DESCRIPTION (provided by applicant): The
STEPHEN J TORDELLA(703) 931- STORDELLA@DECISION-DEMOGRAPHICS.COM DESCRIPTION (provided by applicant): The
HELEN H LEE (408) 773- hhl207@aol.com DESCRIPTION (provided by applicant): Dia
PAUL STROOBANT (978) 927- differentialproteomics@comcast.net DESCRIPTION (provided by applicant): In t
NICHOLAS WRIGHTON (978) 927- nwrighton@differentialproteomics.com DESCRIPTION (provided by applicant): Diff
VIKRAM KUMAR () - DESCRIPTION (provided by applicant): A p
JONATHAN L JACKSON(617) 621- jon@dimagi.com DESCRIPTION (provided by applicant): SPI
KEITH OLSON (510) 979- kolson@discoverx.com DESCRIPTION (provided by applicant): Kin
KEITH OLSON (510) 979- kolson@discoverx.com DESCRIPTION (provided by applicant): Cel
PERRY B HACKETT (612) 656- PERRYH@DUNIVERSITY OF MINNESOTA DESCRIPTION (provided by applicant): Dis
R S MCIVOR (612) 656- MCIVO001@UMN.EDU DESCRIPTION (provided by applicant): Fan
WILLIAM J KENNELLY (734) 222- bill@dnasoftware.com Not avaiable.
KEVIN L MICHAEL (814) 234- KEVIN@MICHAELASSOCIATES.COM DESCRIPTION (provided by applicant): No
JAMES P MCCARTER (314) 812- mccarter@divergence.com DESCRIPTION (provided by applicant): Par
ARTUR G OLSZAK (520) 722- AOLSZAK@DMETRIX.COM DESCRIPTION (provided by applicant): We
DONALD A HICKS (734) 222- DON@DNA-SOFTWARE.COM DESCRIPTION (provided by applicant): Oli
EDWARD A CHRISTMA(609) 919- eac8@comcast.net DESCRIPTION (provided by applicant): The
FRANCIS D DOTY (803) 788- david@dotynmr.com DESCRIPTION (provided by applicant): Th
FRANCIS D DOTY (803) 788- david@dotynmr.com DESCRIPTION (provided by applicant): Ava
MICHAEL J CAVALUZZI(315) 815- mjcavalu@mailbox.syr.edu DESCRIPTION (provided by applicant): Alt
NEAL E HARTSOUGH (818) 280- neal.hartsough@dxray.com DESCRIPTION (provided by applicant): We
NEAL E HARTSOUGH (818) 280- neal.hartsough@dxray.com DESCRIPTION
d drug delivery(provided by applicant):
studies. We The
are developin
WILLIAM C BARBER (818) 280- WILLIAM.BARBER@DXRAY.COM king capabilities and will benefit preclinica
VERA NOVAK (617) 632- VNOVAK@B BETH ISRAEL DEACONESS MEDICAL CENTEDESCRIPTION (provided by applicant): Cer
LANCE DAVIDOW (617) 726- davidow@earthgenes.com DESCRIPTION (provided by applicant): The
GANG ZHANG (323) 268- gzhang@echemics.com DESCRIPTION (provided by applicant): Ech
GERSH Z TAICHER (281) 492- taicher@echomri.com DESCRIPTION (provided by applicant): Acc
JAMES COMOLLI (617) 258- jcomolli@draper.com DESCRIPTION (provided by applicant): Loc
Weiss John () - N/A
SCOTT K SILVERMAN (217) 333- scott@scs.UNIVERSITY OF ILINOIS AT URBAN DESCRIPTION (provided by applicant): My
DIANE ELLISBUSBY (508) 752- dianeeb@ecibiotech.com DESCRIPTION (provided by applicant): Hu
DAVID A LEE (703) 961- lee@edenspace.com DESCRIPTION (provided by applicant): A N
MARK T FISHER (913) 588- MFISHER1UNIVERSITY OF KANSAS MEDICAL DESCRIPTION (provided by applicant): On
PAULA E LANCASTER (785) 749- SVERNON2@ALLTEL.NET DESCRIPTION (provided by applicant): The
ANDREW D HIBBS (858) 373- ahibbs@electronicbio.com DESCRIPTION (provided by applicant): A n
ANDREW D HIBBS (858) 373- ahibbs@electronicbio.com DESCRIPTION (provided by applicant): Ion
KAREN GRAF (301) 251- edvoteked@aol.com DESCRIPTION (provided by applicant): Prin
KEVIN M SPENCER (781) 769- SPENCER@EICLABS.COM DESCRIPTION (provided by applicant)
MICHAEL S WILSON (781) 769- MWILSON@ UNIVERSITY OF FLORIDA DESCRIPTION (provided by applicant): The
Wilson Michael () - N/A
BALAZS RUZSICS () - UNIVERSITY OF ALABAMA AT BIRMINGHA DESCRIPTION (provided by applicant): Th
RONALD OBERLEITNE(208) 629- admin@talkautism.org DESCRIPTION (provided by applicant): We
ENA URBACH (608) 310- ena.urbach@emetagen.com DESCRIPTION (provided by applicant): The
MARTIN C BARUCH (434) 296- MCBARUCH@comcast.NET DESCRIPTION (provided by applicant): The
JOHN F SPRINGER (916) 983- FRED@EMT.ORG DESCRIPTION (provided by applicant): The
JOHN F SPRINGER (916) 983- FRED@EMT.ORG DESCRIPTION (provided by applicant): De
CORINE A BICKLEY (617) 293- ENABLEREHAB@VERIZON.NET DESCRIPTION (provided by applicant): Voi
NIMMI RAMANUJAM(919) 660- nimmi@duDUKE UNIVERSITY DESCRIPTION (provided by applicant): In
WEILIAM CHEN (631) 632- wchen@endomedix.com DESCRIPTION (provided by applicant): Bra
WEILIAM CHEN (631) 632- wchen@endomedix.com DESCRIPTION (provided by applicant): The
STEPHEN HORNE (781) 939- shorne@energetiq.com DESCRIPTION (provided
ividual cells, and by in
advances applicant): Soft
imaging tech
STEPHEN HORNE (781) 939- SHORNE@ENERGETIQ.COM Microbeam Facility for Small Laboratories
PETER C ARIESSOHN (425) 432- peter.a@enertechnix.com DESCRIPTION (provided by applicant)
MICHAEL T CARTER (303) 530- eltron@eltronresearch.com DESCRIPTION
echnical aims (provided by applicant):
of the project include theThe
sy
CHRISTOPHER L MAR() - the 2 million workers who encounter this
e determined. Phase I results will prove th
JOHN D FAULL (303) 530- ELTRON@ELTRONRESEARCH.COM and accurate monitoring will allow worke
DARION RAPOZA (919) 321- DarionRapoza@entertainmentscience.com DESCRIPTION (provided by applicant): The
DWANE E WYLIE (215) 687- DWYLIE1@UNLNOTES.UNL.EDU DESCRIPTION (provided by applicant): Anti
Gartner Mark () - N/A
JAFAR VOSSOUGHI (301) 570- VOSSOUGHI@VERIZON.NET DESCRIPTION (provided by applicant): Res
JIE XU (860) 486- JXU@EVERGEN.COM DESCRIPTION (provided by applicant): The
TAMIE CHILCOTE (415) 596- tamie.chilcote@activesitepharma.com DESCRIPTION (provided by applicant): Mo
LAWRENCE M KAUVA(415) 567- KAUVARLM@EARTHLINK.NET DESCRIPTION (provided by applicant): In P
JASON G FEWELL (256) 512- JFEWELL@EGENCORP.COM DESCRIPTION (provided by applicant): The
JOHN D SHEPPARD (757) 624- johnsheppEASTERN VIRGINIA MEDICAL SCHOO DESCRIPTION (provided by applicant): De
NEAL F GORDON (781) 891- ngordon@epitomebiosystems.com DESCRIPTION (provided by applicant): The
MICHAEL J LANE (315) 464- LANEM@UP SUNY UPSTATE MEDICAL UNIVERSIT DESCRIPTION (provided by applicant): Th
ANNE S DEGROOT (401) 272- annied@epivax.com DESCRIPTION (provided by applicant): Thi
ANNE S DEGROOT (401) 272- annied@epivax.com DESCRIPTION (provided by applicant): He
CHING WU () - DESCRIPTION (provided by applicant): Ass
MICHELE L MERVES (352) 225- smerves@xhalediagnostics.com DESCRIPTION (provided by applicant): Eth
RICHARD J MELKER (352) 846- RMELK@UFL.EDU DESCRIPTION (provided by applicant): Prin
ROBERT LENK (540) 552- submissions307@lunainnovations.com DESCRIPTION (provided by applicant): Ath
JEFFREY SMITH () - DESCRIPTION (provided by applicant): Acc
PATRICK S COTTLER (434) 972- cottlerp@lunainnovations.com DESCRIPTION (provided by applicant): Ma
Pruzan Michael () - N/A
al translation that simulates 2D array, mod
ALEXANDER A ORAEV(713) 772- AORAEVSKY@FAIRWAYMED.COM ast cancer. Successful accomplishment of
SUSAN MEDGHALCHI(410) 558- susan.medghalchi@fasgen.com DESCRIPTION (provided by applicant): Du
J M WEBER (312) 738- mark.weber@fermalogic.com DESCRIPTION (provided by applicant): A t
J M WEBER (312) 738- mark.weber@fermalogic.com DESCRIPTION (provided by applicant): Fer
J P KAMPF (858) 455- pkampf@tpims.org DESCRIPTION (provided by applicant): Jau
GAUTAM S GHATNEKA(843) 901- ghatnek@musc.edu DESCRIPTION (provided by applicant): Ac
STEVEN A BENNER (352) 271- sbenner@fFOUNDATION FOR APPLIED MOLECUL DESCRIPTION (provided by applicant): The
CHRISTOPHER STRIEM(585) 746- striemer@ece.rochester.edu DESCRIPTION (provided by applicant)
Striemer Christophe () - N/A
FARZAD EHSANI (408) 747- farzad@fuentialinc.com DESCRIPTION (provided by applicant): The
GREGORY D GILLISPIE(701) 237- gillispie@dakotatechnologies.com DESCRIPTION (provided by applicant): Tis
NICOLA L POHL (515) 294- NPOHL@IAIOWA STATE UNIVERSITY DESCRIPTION (provided by applicant): The
CRISTIAN IONESCUZA(510) 816- Cristian.Ionescu-Zanetti@fuxionbio.com DESCRIPTION (provided by applicant): Pha
MICHAEL O KELLY (704) 357- mkelly@fyingbridge.net DESCRIPTION (provided by applicant): In s
THOMAS C DELAHANT (818) 710- TOM@FORSYTHETECHNOLOGIES.COM DESCRIPTION (provided by applicant): Gla
HANWEN MAO (240) 631- hmao@functional-genetics.com DESCRIPTION (provided by applicant): Hu
HIROYUKI FUJITA (440) 248- Hiroyuki.Fujita@case.edu DESCRIPTION (provided by applicant): Min
MEHARVAN SINGH (817) 735- MSINGH@H UNIVERSITY OF NORTH TEXAS HEAL DESCRIPTION (provided by applicant): The
DAVID PICKAR () - DESCRIPTION (provided by investigator):T
tworks have evolved into a ubiquitous infrastructure, and the Internet has become a mission-critical asset for governments, companies, ins
amaterials promise to improve radically the ability of structures to evade sonar detection. The physics of these “acoustic mapped metamat
of this effort we analyzed the structural response of a BLU 109 during typical penetration events. Based on these finite element results, w
develop a suite of User Toolkits for SONAR Transducer Design, to enable rapid and accurate evaluation of new design concepts, allowing qu
er Associates Inc (WAI) will develop a new generation of fuel injectors incorporating single crystal piezoelectric actuators for use in Pulse De
iences proposes to develop the Template Identification Processing System (TIPS), a very-high-speed digital signal processor implemented o
g the response of building components to internal detonations is more complex than the corresponding task for external loads because of t
iences proposes to formulate a class of burst-mode communication waveforms tailored for future MDA interceptor communication system
e Phase I , Western DataCom developed an identity-based security architecture and a fexible key distribution system using identity-based s
hods for scuffing and fatigue are available to assess surface technologies for high power density gears. Five key tribology parameters are id
ctive of the proposed work is to develop a detailed description and methodology for an intuitive, real-time bioluminescence risk detection a
ently scalable solution for determining optical properties important for surfzone mine-countermeasures (MCM) and basic research will be d
Pyro is developing an AccuTag Miniature Surveillance and Tracking System (Accu-MiSTS). Accu-MiSTS employs cluster management techniq
are highly susceptible to fuctuations in wireless link quality due to inherent mobility. Mobility results in frequent changes in the propagatio
methodologies for integration of weapons on unmanned and manned aircraft platforms and the associated control software development/i
ram will develop a thin film passive wireless temperature sensor that will: 1)Measure the surface temperature of the Thermal Barrier Coate
ost-effective Digital Beamformer (DBF) architecture is proposed. The application of COTS components, used in the manufacture of consum
evaluation of possible IWRC type ropes will be completed including suggested parameters to be investigated. The approved designs will be
eration and sophistication of malicious code today is staggering. Within hours of the discovery of a new vulnerability, related exploits appe
ment of an existing microwave generated plasma igniter including a detailed computational modeling effort is proposed. This igniter genera
fire suppression is a key contributor to aircraft survivability in a war zone. Many aircraft lack effective fire suppression in the wings and avio
A needs a fexible, miniature, reconfigurable radio suitable for long-term operation (one year or more) on battery power and capable of be
power-hungry electronics that give the United States’ forces an overwhelming advantage on the battlefield increasingly strain the logistica
urveillance systems often use mounted cameras to capture video imagery and a range of sophisticated sensors and stand-alone security de
ctive of this research is to develop and demonstrate new architecture methodology constructs for information systems to provide effective
e energy absorbing systems and restraint components are proposed as elements of a stowable seat design for troops transported in helicop
osal describes XTI’s plan for evaluating optical technologies and fielded fiber optic RF links (FORL) in airborne ISR platforms to design new F
ystems' proposed solution is a comprehensive system for data acquisition, storage and playback of wideband RF signals. This design utilizes
poses to develop a family of small propulsion systems based on small thrusters (1 to 250 N). We will address the issues such as good thrust
roposing to study the combination of desensitized nitromethane (CH3NO2) and gaseous oxygen (GOX) as a propellant combination. Nitrom
ency of electric motors and generators operating with high rotor surface speeds is reduced due to viscous shear and aerodynamic effects.
tran Corporation and PrismTech Solutions Americas Inc. (PSA) (the “Team”) along with the U.S. Government proposes to design and develo
r Force-funded work under the Phase II contract will focus on augmenting existing commercial vehicle development program to implemen
l Business Innovation Research Phase I project is to develop a compact deployable micro immersive display component for augmented rea
WWTG will develop enabling tools and processes for performing security policy reconciliation and composition. The combination of a prov
on of systems with Information Assurance requirements is challenging and expensive due to the lack of powerful abstractions that permit
nuclear submarines deploy many distributed computing systems that comprise a sophisticated set of functions to deliver dependable soluti
wer, lightweight hyperspectral imaging system with automated image analysis and data optimization for real time target detection and com
osal is to develop an Ultra High Frequency (UHF) reuse tool software product to help maximize the capacity of UHF SATCOM resources. The
osal is to develop a SATCOM toolset to provide the military SATCOM community the ability to examine communications systems’ performa
quired to comply with EPA acceptable opacity levels, whereas training operations often involve smoke plumes and a portable measuremen
for atmospheric pressure, temperature and wind (PTU+wind) vertical profile data over the data sparse open ocean remains a significant pr
osal is to investigate IntServ signaling protocol options suitable to provide reservation-based QoS in an airborne network composed of hete
Technical Products, (YTP) proposes to develop, test and deliver high-performance Li-ion batteries capable of operation at expanded temper
igation proposes to develop the MOUTman, a rugged, handheld, secure, high-precision real-time navigation system suitable for military op
igation proposes to develop the SOCOM divePDA a rugged, secure, high-precision, handheld real-time navigation and communications syst
NGINEERING will determine the sources and approximate percentage of contribution to the co-mingled TCE plume located at the governme
osal examines several methods for preventing shipboard SINCGARS transmitters from overdriving a cosite sensitive signal exploitation rece
ng of nano-structured particles (PNP) process produces powder particles with a nano-structure by using high-speed printing techniques co
osal presents a novel method for implementing a bank of notch filters at the output of a wideband high power amplifier that are each inde
rams Incorporated (ZA) proposes an innovative technique to maintain deep cancellation of cosite JTRS Wideband Networking Waveforms tr
ctive of this proposal is to demonstrate the feasibility of developing advanced battery chemistries that provide batteries operate safely at sp
osal examines a combination of proprietary techniques for preventing shipboard SINCGARS transmitters from overdriving and desensitizing
e major challenges of developing solar power generation systems is the storage of electrical energy. The energy system ideally has a large a
n of weak oceanic currents by remote sensing means is an important task for many applications of significance to the Navy and the society
l Business Innovation Research Phase II project will advance an efficient and lightweight energy storage device for Unmanned Air Vehicles (
oses to investigate advancing the capabilities of our Smart Towed Vehicle to be mounted and operated onto a more diverse range of aircraft
evelop a compact THz system with standoff spectroscopic detection capability, using an intense 1-μm Yb fiber laser with a tilted optic
team member UCSD propose a ground-breaking new micro-scanning technology capable of rapid scanning over a wide Field of Regard wh
A Team proposes to develop a nonlinear aeroelastic/aeroservoelastic methodology for free-play (FP)/LCO analysis and prediction for aircraft
am proposes in Phase II to develop a general nonlinear methodology with a new and expedient reduced-order-modeling-based procedure a
e Phase-I research we only spent 6 months (not 9 months) an air droppable rolling weight defectormeter (ADRWD) was built and a concep
Phase I project will develop a hand-held sensing and alarm system for ultra-trace concentrations of chemical gases, biological aerosols, and
osal exploits nano-materials to achieve exceptionally high energy in an 18650-size cell. The successful development of this cell will provide
osal describes a superior high-energy density and high-rate, rechargeable, 18650-size cell for Army applications based on a novel, ultrasafe
Maglev Technology, Inc. (AMT) is pleased present this Phase II proposal of the Navy’s Advanced Eddy Current Braking Technology STTR to
and operability of high performance infrared detectors, particularly those based on HgCdTe, are severely compromised by materials defect
ability to perform dexterity work is greatly diminished in long duration missions if his hands are cold. Research has demonstrated that prot
actor shall work in concert with the government to research, design, develop, fabricate and evaluate a digital voice technology prototype u
osal addresses the need for a fexible, high performance, multi-parameter test bed for infrared focal plane arrays. An adaptable brass-boar
osal describes an innovative radiation hardened by design approach for improving integrated circuit reliability while minimizing impact on a
e Phase I project, we have developed a Polarimetric Imaging System (PIS), integrated it with the 3-D Flash Ladar (FL), and have demonstrate
esearch Company (ERCo) proposes the development of an instrument that provides novel real-time control of laser decoating processes by
ss personal water heater will be developed that is capable of heating small individual volumes of water for meal preparation, sanitation, or
osed task creates the design for a robotic system (Unmanned Surface Vessel (USV))to control and conduct unmanned and unsupervised ref
ormance infrared detectors are mission-critical components of each layer of the Ballistic Missile Defense System. MDA is investing heavily i
ted metal hydride with high gravimetric hydrogen density and high volumetric hydrogen density has been proposed for application as a hyd
sickness prevents the use of simulators immediately prior to a mission. The main cause for simulator sickness appears to be a mismatch b
signature of the USMC Expeditionary Fighting Vehicle (EFV) is excessively high for human safety factors, and impedes stealthy land operati
prosthetics have improved significantly with regards to control and functionality, but the fit of the residual limb within a prosthetic socket is
um sheath that currently protects most leading edges of rotary wing aircraft is plagued with several issues associated with the thermal dei
rne diseases have posed a significant threat to soldier health in past and present foreign deployments. Currently deployed troops face seve
ates Navy, United States Air Force, and European Air Force have documented neck injury rates of 50% or higher ranging from minor neck st
n and disinfection of food products and food-contact surfaces is a major concern of forward deployed military forces. Current DoD protoco
of transmissible spongiform encephalopathy (TSE) are caused by a unique infectious agent termed “prion”, a proteinaceous pathogen lacki
of nuclear materials, military ordnance, and chemical and biological threat agents presents a significant challenge to the intelligence and m
d Network Centric Warfare (NCW) systems are critical to the successful implementation of the Army’s future force. To achieve accurate, sec
protection which targets the airborne vibrations traditionally associated with hearing has advanced considerably in the last two decades. A
proposes an innovative seating system for helicopter mobile aircrew, which is designed based upon a number of creative ideas. (a) A turni
osal addresses the space optic community’s need for an optical bonding material with superior stability in the harsh space environment. A
an incredibly rich source of information, but the information contained in a map is often locked up in a raster image. Sometimes the origin
ar LLC with support from academia, Quinstar and other supporting businesses proposes to develop advanced capability for feature-aided t
posing to integrate electrical conductors and antennas directly into composite structures using a new Synergistic Composite Conductor (SC
 mers are promising highly-specific, environmentally-stable threat-detecting molecules. Unfortunately, the current method for generating th
ditionary Fighting Vehicle (EFV) has two aft exhaust ports that interface the heat exchangers to the external environment. An innovative so
ar LLC with support from Academia, Quinstar and other supporting businesses proposes to develop a W-Band Circular Electrically Scanned
osed work addresses the problem of determining whether a given small unmanned ground vehicle (SUGV) can traverse a given terrain, whe
oposed work, goal of Hood-Impact Systems (HIS), a joint venture (JV) between Hood Technology Corporation and Impact Technologies, LLC
start of U.S. involvement in the Middle East following 9/11/2001, field missions in these far field theatres have proven to be extremely dan
on has considerable negative effects, and is a constant threat to our troops, who by necessity are physically active, weighed down by nume
isticated technology of U.S. military weapons systems provides battlefield advantages that can save lives and reduce equipment loss. Elect
g the ability of ground-based simulators as a training mechanism for fight will enable faster and potentially more solid training of fight cre
estion into aircraft engines, including diesel platforms for UAVs, can cause severe erosion of components. This erosive wear reduces engine
e the Navy with a successful means of creating configurable underwater sensor networks an acoustic sensor system that can be mobile and
orientation and position tracking is difficult to achieve over extended missions and in varying environments, such as ambient electromagne
ect proposes to develop a rapid ethnographic assessment tool designed specifically to be used by military personnel participating in Securit
um-oxygen electrochemical couple has the potential to form the basis of a very high specific energy, rechargeable battery for the very high
deployed defense space systems are hardened against naturally occurring environmental radiation. Man-made radiation threats such as la
nt fight helmet provides impact protection while enabling communications and serving as a platform to mount helmet mounted devices (H
etal matrix composite material consisting of natural graphite particulates processed into a designed reinforcement architecture that, after p
etal matrix composite material consisting of natural graphite particulates processed into a designed reinforcement architecture that, after p
developed a novel class of phosphatidylcholine (PC)-associated nonsteroidal antiinfammatory drugs (NSAIDs) to treat infammation and pa
conformal coatings, composites and elastomers capable of shielding high power microwaves (HPM) is proposed. Based on nickel nanostra
obscurants are commonly used to screen soldiers and assets from enemy threat. In order to improve this countermeasure, materials super
gy is rapidly advancing both in the area of thermoelectric (TE) modules and solid oxide fuel cells (SOFC). Advanced solid oxide fuel cells are
obscurants are commonly used to screen soldiers and assets from enemy threat. In order to improve this countermeasure, materials superi
ide optical isolator is proposed based on ultrahigh Verdet constant s. Prelminary measurements on these materials indicate Verdet consta
, University of Pennsylvania (UPenn) and University of Washington (UW) are teaming to propose to develop next generation EO modulato
idents due to failure of rolling element bearings in aircraft gas turbine engines are a significant cost to the Department of Defense. Oil deb
seeking an universal sample preparation methods for extraction of nucleic acid capable of being used in many different assay systems for s
n Health Management (PHM) of advanced aircraft propulsion systems refers to a multi-faceted approach of sensitive and precise monitorin
rodeless Lorentz Force (ELF) Thruster is a new propulsion device designed to operate at the highest jet powers, well beyond the currently d
all goal of the program is to develop an optical limiter without a focusing lens that provides sufficient attenuation to prevent eye damage at
osed system is a wide field of view helmet mounted system that will incorporate short wave infrared (SWIR) camera technology with dual im
need for the ballistic missile defense system (BMDS) is the determination of the warhead type contained within the intercepted threat. Kn
ng term vibration problems have cost AEDC thousands of labor hours from maintenance resources. These problems involving compressors
Logix, Incorporated (CLX) proposes the Software Defined Radio Waveform Development Kit (SDR-WDK) program to facilitate the developm
Bladed Rotors – IBRs – are an important part of current and future military aeroengines. The use of IBR allows lower weight rotors with d
t of the proposed research effort is to identify the critical thinking skills that apply particularly to the reasoning and understanding of comp
ore simulation models used for defense development and evaluation fail to accurately model lethality for many standoff engagement optio
osed that a Phase I SBIR be conducted to evaluate the feasibility of developing a POSS-based (Polyhedral Oligomeric Silsesquioxanes) coatin
units operating on foot in remote regions are highly dependent on electrical energy for communications, navigation and sensing. As the us
numerical analysis applications have proven to be effective and reasonably accurate, the effort required to develop the associated analysis
hic failures in aircraft electrical power systems can compromise the readiness, safety, and capabilities of the war-fighter. In this effort, a mu
the research and analysis conducted during Phase I, it was determined that it is feasible to detect, diagnose, predict and manage impendin
orporation and the Missouri University of Science & Technology (MS&T) propose to develop novel high-strength and optically transparent g
ot team proposes to develop a deployable pedestrian detection module that will analyze a monocular video stream and identify all instance
ary objective of this project is to develop a number of classes of novel miniature inertial igniters for thermal batteries that are suitable for g
of this project is to design, build, and test an active electromagnetic induction (EMI) sensor array for detecting and characterizing IEDs. At l
plicity of existent wireless networks and technologies creates the need for techniques that can allow devices to automatically transit betwe
 ase II SBIR Army Program, Physical Sciences Inc. will design, build, and test a novel high-gain, quasi-volumetric, directive antenna array com
ct, rugged, mobile, integrated automated-identification-technology warehouse system will be designed, built and demonstrated for use in m
of studies involving the effects of army materiel on ground soldier task performance exist, but the fow of data from these studies into grou
esent time there is no system to monitor the progress of medical shipments to and within the combat theater other than those pallets that
eration EO/IR Nanosensors are needed for a variety of Military Systems Applications. These include UV, Visible, NIR, SWIR, MWIR and LWIR
solid performance is needed to meet Integrated High Payoff Rocket Propulsion Technology (IHPRPT) Program goals. New hydroxy-terminat
cience for Mars and lunar exploration demands that fairly small diameter intact rock cores be acquired for geologic evaluation. Tools to acq
ose of the proposed project is to develop and demonstrate an autonomous robotic platform able to perform long-range, long-endurance m
s pleased to propose the development of an ultra-low noise amplifier (LNA) based on superconductor quantum interference filter (SQIF) te
TRA system monitors battery health by comparing observed voltage, current, and temperature data to models of both known healthy and k
kes, passive MMW imaging polarimeter has been designed that is capable of being deployed on an unmanned aerial vehicle. The system is
ary objective of this project is to develop a class of novel low-cost programmable miniature electrically initiated inertial igniters that operat
search, LC, in proposes to transition the newly developed photonic blade tip clearance sensor from a low temperature prototype to a full sy
nd military organizations throughout the world perform vector surveillance to identify and control diseases transmitted by arthropods. The
all cost of each of the 20 million general anesthetic procedures performed in the United States each year. Reducing the recover time by 20
nts by 60%.
ial wild harvest of rainbow smelt populations is the principal source for supplying both the live bait and human consumption markets for t
nt emergence of the Silicon Drift detector (SDD), for use in Energy Dispersive x-ray Spectroscopy (EDS), has made possible x-ray event stream
Phase 1 SBIR effort will demonstrate the feasibility of low noise single photon up conversion using KTiOPO4 (KTP) or LiNbO3 (LN) or Stoich
Technologies, Inc. Phase I effort will be to design and demonstrate the feasibility of developing a low-cost, marinized Unmanned Aerial Sys
ho work in the marine sciences field often need to analyze the transmission of sound through the ocean. Today, there are more than 60 di
osed effort is to build a high resolution, high speed spatial light modulator (SLM) to be used in infrared (IR) spectral projectors. An IR spectr
deals with developing a commercial AC Resistance-Ratio Bridge based on research work done by R. D. Cutkosky at NIST during the 1980's.
ose to evaluate tree dominant semantics for description logic integrity constraints, as well as multiple proposals for adding syntax for integr
plementary techniques are proposed that are deployable on dropsondes or mobile measurement platforms and measure the scattering co
agTM project proceeds in Phase II to implement and test a family of micro observation stations that go beyond the concepts of traditional e
on of highly stable optical clocks into electrical clocks through photodetection introduces excess phase noise and degrades the frequency st
o realize robust, inexpensive and routine DNA sequencing for medical, forensic, security and defense applications, new approaches must b
vative technology for the visually impaired has been developed by NIST. If commercialized, it would provide refreshable tactile graphical in
hemical vapor deposition (CVD) based step-fow epitaxy process is proposed for controllable growth of SiC nanowires with high polytype in
pports over 25,000 underwater dive programs per year. To increase the duration and depth of these dives, the use of closed circuit mixed g
ase I test, Green Eyes successfully demonstrated the feasibility of a Coastal Long-Term Automated Self-Calibrating Profiler (CLASP) system c
years, there has been increasing concern about the role of man-made sound on the marine environment. For this effort, we propose deve
nd study candidate architectures for supporting and cooling massive (~5 Kg) arrays of transition edge sensors, achieving hold times for one
ter monitoring systems are presently prohibitively expensive. There is a long-term reliability issue with them as well, as the electronic acou
esearch is needed to define the critical criteria for commercial-scale hatchery culture and growout of this species. Phase II research addres
proposed will provide a demonstration of feasibility and specific design recommendations for building an elevated-temperature resonatin
upercontinuum (SC) light sources are generated by non-linear interactions between ultrashort pulse lasers and optical fibers. Output in ne
osal introduces the Detecting Intrusion from Network Anomalies (DINA) system, which uses data mining tools to automatically detect anom
project aims to develop a new class of low-field magnetic sensors based on magnetic tunnel junctions with magnesium oxide (MgO) tunne
Precision Time Protocol (PTP) protocol has significant advantages for relative time synchronization on wireless networks.
ean finfish aquaculture presents many challenges including net handling, scuba diving in adverse conditions, maintenance, and feeding. In
rm Technologies (OFT) proposes to examine using ocean wave energy to power offshore aquaculture. While developing offshore fish farm
hysics Company is proposing a three axis interferometer instrument which measures the one dimensional linear translation and the two-dim
tion of particular fish species based on specific DNA sequences is not currently time or cost effective, but morphological identification is no
ons are simple, compact devices that offer many times more dispersion than gratings and are finding increasing application where higher sp
strong correlation between cloud-to-ground (CG) lightning and the altitude of the 40-dBZ radar refectivity levels with respect to the heigh
 osal describes the development of compact radiometer receiver modules intended for use in hurricane wind speed imaging radiometers an
A strategic vision is to help realized ¿an informed society that uses a comprehensive understanding of the role of the oceans, coasts, and
anagers are increasingly recognizing climate change as a significant issue and are requesting detailed information about potential hydrologi
st Sciences proposes development of residential fire sensing systems based on low cost optical imaging sensors combined with newly introd
ay as a highly technical and advanced world civilization the physiology of deep sea fish and invertebrates continues to remain mysterious an
technology transfer program offers the opportunity to produce a new generation of advanced large area and monolithic pryoelectric detec
tor of international efforts to identify and suppress the supply of and demand for nuclear materials, and thereby to deter potential trafficke
osed Phase I SBIR research effort will demonstrate the feasibility of collecting GPS position and single-beam sonar water depth data from a
lid-state, carbon dioxide (CO2) sensor for use with closed circuit mixed gas rebreathers is proposed. This novel, polymer composite sensor
barrier methods are necessary to protect furniture and mattresses from fire. Current California (and soon National) regulations require matt
mmercial filters have significant loss even in the passband of the filter. This problem is further exacerbated when the filter must be integrate
s proposal, Virtual Global, Inc. proposes to work with NIST to develop RBAC-BASED WORKFLOW, a workfow system that will use RBAC in a
oposes to develop fiber-coupled near-infrared avalanche photodiode (APD) receivers with photon detection efficiency (PDE) and dark coun
practical arrangement for investigating moving fires within a restricted space is to use a high- resolution stand off technique. One such me
lopment of a sensitive, affordable instrument for ammonia detection has wide benefits for atmospheric and environmental research. This n
industry faces a costly problem in localizing leaks of pollutant gases to meet regulations or limit toxic releases. The proposed technology w
all goals of this Phase I grant are to employ microarrays to identify genes that fuctuate in fathead minnows after acute exposure to nanotub
osed project is for the experimental operation and performance review of a pilot-scale anaerobic digester and effluent treatment system fo
of this research project is to develop a rapid assay kit for cyanobacterial anatoxins using aptamers as the primary molecular recognition el
nologies require convincing evidence to enter strongly in the marketplace. Phase I is our proving-ground to the U.S. Environmental Protecti
will build and evaluate pilot system. Fortunately we have established a number of key relationships with membrane suppliers, ethanol engin
ect describes a new technology in which an adsorbent captures the PM2.5 and VOCs, stores them for a time, and then cleans itself by perio
ram will demonstrate the capabilities of a hand-held sensor that potentially could be used in-line. This sensor is based on the technique of
s a long history of developing electrolytic water treatment systems and has a pilot-scale H2O2 generation system currently under evaluatio
nclusion of Phase I, Eltron will have demonstrated the feasibility of zero ammonia diesel exhaust after-treatment technology for NOx abate
ul completion of the program will result in a simple and practical decontamination technology for first responders, and other handlers of ha
nt U.S. Environmental Protection Agency (EPA) SBIR solicitation states that technology is needed to better identify and monitor sources of
ived from cellulosic biomass offer an alternative to conventional energy sources that supports national economic growth, national energy s
lopment of a no-maintenance, easily constructed, reliable detector for NO2 would greatly facilitate the development of the chromatograph
ate, portable and reliable ClO2 monitoring device capable of wireless data transmission could find a broad commercial use. The proposed h
vative aspect of the proposed detection method is that immunoassays can be performed in a simplified manner where no additional reage
n of the SP electrodes lends itself to use with electrostatic precipitators with very little change to their basic design. If demonstrated at full
ram entails the development of new catalyst compositions for the glycerol conversion reactions: laboratory studies demonstrating the perfo
ase II study Lesktech will design and operate a 1-5 ton per hour pilot plant to process the stampsand material. The G-sand will be sized and
water recycle and reuse is considered good environmental practice, its implementation is highly dependent upon the economics and henc
m is produced by the Kroll process, which is a batch process for the magnesium (Mg) reduction of titanium tetrachloride (TiCl4). Separate o
ediate application of this electrochemical reactor technology is toward an improved chlorination process for small communities in Puerto R
er accounts for 50 percent of the electricity in the United States. The current market is $100 to $200 billion per year and has the potential
e is uniquely qualified for the proposed development since it is a leader in the field of reactive nanocrystalline materials.
et for HB LEDs was $4.2 billion in 2006 and is expected to grown to $9 billion in 2009. Estimations show the LED Phosphor market associate
Recovery Technologies is a major manufacturer of recycling equipment for the post-consumer plastics recycling industry and has received c
ry experiment results show that the MVCO fuel injector is capable of reducing NOx emissions by about 40 percent, and reduces fuel consu
mercial application is a new chemical production process for producing low-cost biodiesel. The main innovation of the product is the ability
nized that the primary applications for TERRACAP¿ CB Detox will include homeland defense, the Department of Defense, first responders
n Team, Inc. (tGT) will conduct Phase I research to determine characteristics of green product-service systems (GPSS) in the building produc
project seeks to improve the emissions performance of the burnbox while maintaining its target community usability. While not measured
m is produced by the Kroll process, which is a batch process for the magnesium (Mg) reduction of titanium tetrachloride (TiCl4). Separate o
all goals of this Phase I grant are to employ microarrays to identify genes that fuctuate in fathead minnows after acute exposure to nanotub
vative aspect of the proposed detection method is that immunoassays can be performed in a simplified manner where no additional reage
n Team, Inc. (tGT) will conduct Phase I research to determine characteristics of green product-service systems (GPSS) in the building produc
s a long history of developing electrolytic water treatment systems and has a pilot-scale H2O2 generation system currently under evaluatio
of this research project is to develop a rapid assay kit for cyanobacterial anatoxins using aptamers as the primary molecular recognition el
nt U.S. Environmental Protection Agency (EPA) SBIR solicitation states that “technology is needed to better identify and monitor sou
ect describes a new technology in which an adsorbent captures the PM2.5 and VOCs, stores them for a time, and then cleans itself by perio
n of the SP electrodes lends itself to use with electrostatic precipitators with very little change to their basic design. If demonstrated at full
er accounts for 50 percent of the electricity in the United States. The current market is $100 to $200 billion per year and has the potential
industry faces a costly problem in localizing leaks of pollutant gases to meet regulations or limit toxic releases. The proposed technology w
lopment of a sensitive, affordable instrument for ammonia detection has wide benefits for atmospheric and environmental research. This n
nclusion of Phase I, Eltron will have demonstrated the feasibility of zero ammonia diesel exhaust after-treatment technology for NOx abate
ived from cellulosic biomass offer an alternative to conventional energy sources that supports national economic growth, national energy s
mercial application is a new chemical production process for producing low-cost biodiesel. The main innovation of the product is the ability
Recovery Technologies is a major manufacturer of recycling equipment for the post-consumer plastics recycling industry and has received c
project seeks to improve the emissions performance of the burnbox while maintaining its target community usability. While not measured
nologies require convincing evidence to enter strongly in the marketplace. Phase I is our proving-ground to the U.S. Environmental Protecti
ediate application of this electrochemical reactor technology is toward an improved chlorination process for small communities in Puerto R
ram will demonstrate the capabilities of a hand-held sensor that potentially could be used in-line. This sensor is based on the technique of
ul completion of the program will result in a simple and practical decontamination technology for first responders, and other handlers of ha
nized that the primary applications for TERRACAP™ CB Detox will include homeland defense, the Department of Defense, first respo
e is uniquely qualified for the proposed development since it is a leader in the field of reactive nanocrystalline materials.
et for HB LEDs was $4.2 billion in 2006 and is expected to grown to $9 billion in 2009. Estimations show the LED Phosphor market associat
ase II study Lesktech will design and operate a 1-5 ton per hour pilot plant to process the stampsand material. The G-sand will be sized and
will build and evaluate pilot system. Fortunately we have established a number of key relationships with membrane suppliers, ethanol engin
ram entails the development of new catalyst compositions for the glycerol conversion reactions: laboratory studies demonstrating the perfo
ate, portable and reliable ClO2 monitoring device capable of wireless data transmission could find a broad commercial use. The proposed h
water recycle and reuse is considered good environmental practice, its implementation is highly dependent upon the economics and henc
lops and commercializes intelligent instrumentation modules. Our product emphasis is on instruments mounted in aircraft wiring connecto
ment Sciences has developed a layered algorithmic framework for high dimensional data analysis and fault detection focusing on multi-sens
ufactures multi-processor instrumentation modules. Our latest product is the Embeddable Programmable Instrumentation Circuit (EPIC). Th
bers are extensively used in military aircraft, both as interconnects in electronic cards and as interconnects in aircraft frames. Fiber ribbons
used wire harness technology consisting of Tefon-Kapton-Tefon (TKT) composite tape has significant performance issues such as hydrolys
n and countermeasure of Laser Activated Devices (LADS) in today’s battlefield is of great importance. Current optics detection technology c
ect develops an innovative, enabling technology for precision attitude control of guided munitions. An imaging sensor system is used to pre
gy research and development in such areas as next-generation atomic clocks, quantum information processing with trapped ions, and atom
sociates (Areté) proposes to develop advanced algorithms for landing area characterization from LADAR data for the purpose of assisting he
poses to create the software application PERICLES (PERIscope CLassification of Ships) capable of automatically recognizing and classifying m
e major technical challenges of modern military and commercial rotary wing aviation is effective instrument aided navigation in brownout
al limiter of airborne MAD systems is geomagnetic noise. The long coherence length of geomagnetic noise recommends the use of correla
em of sniper detection and neutralization proves to be one of the more significant issues facing the troops presently deployed in Iraq and A
years the number, capabilities, and types of Unmanned Aerial Vehicles (UAVs) has grown dramatically, resulting in an increase in the variet
demonstrated need for improved detection of improvised explosive devices in the modern battlefield. Thermal detection of disturbed soi
stems such as Hellfire provide outstanding lethality, but use traditional gimbaled seeker heads that are too expensive and heavy to meet in
mined, hard-wired processing architectures with static resource allocation and task distributions suffer from single points of failure, inefficie
d reliable identification or discrimination of friendly and hostile targets at beyond visual ranges remains a major technical challenge that ma
ociates has created a software architecture to develop a fexible, user-friendly modeling and simulation tool providing a capability for perfo
 arial submarines become quieter and operate in increasingly adverse acoustic environments, the U.S. needs effective non-acoustic detectio
ETOC products are required for planning efficient and safe expeditionary warfare operations in the littorals. Present Navy programs are ad
ociates’ is proposing to develop a hyper-spectral, IOP sensor system that can be deployed by a variety of means in the surfzones of forward
I of this SBIR program, Areté Associates proposes to demonstrate the Inboard Magnetic Quieting System (IMaQS) and develop the Electric
ng bathymetry changes in shipping channels of rivers and estuaries is vital to the US economy. The standard method of sonar depth sound
ect develops and evaluates a prototype signing Science Pictionary (SSP) for bothpersonal computer and handheld applications. The mobile
hase II SBIR project, Vcom3D will develop a distributed interactive simulation in which Soldiers can practice interactions with a local popula
ect develops software for hand held devices for use in elementary and secondarygrades. During Phase I of this project, Vcom3D developed
lnctional
Businessintegrity
Technology Transfer
of the sacculeResearch
and the (STTR)
inferiorPhase I project
vestibular addresses
nerve. The usethe scale-up
of the to kilogram
proposed quantities
VEMP system of a novel
is expected to university laborator
greatly improve the
developing better VEMP testing systems.
ical simulations have grown in size and complexity, it is becoming increasingly difficult to manage the execution of the computational proc
le accelerator modeling is vital to the design and optimization of particle accelerators, and visualization is an indispensable component for
have reached a strong consensus that human emissions of greenhouse gases are causing global warming. The Intergovernmental Panel on
(CH4), water vapor (H2O), and carbon dioxide (CO2) are collectively responsible for the majority of the Earth¿s greenhouse effect. Robus
cal measurement techniques are presented for imaging of strain and temperature of high temperature materials used in turbine engines. Th
e I SBIR proposal addresses an Air Force need for enabling use of Coherent Anti-Stokes Raman Spectroscopy (CARS) for non-intrusive meas
nd operationally simple methods that can be used in the field are needed for observationally-based prognosis of remaining fatigue life. Pre
osal seeks to produce a unique instrument for fight-line NDE and defect detection in aerospace composite structures based on integration
aser beam delivery on a distant extended target remains a key problem for practical implementation of laser systems. Since the convention
proposal to develop an electronic, focusing schlieren system for fight research based on electronic cameras and spatial light modulators as
s the need for non-intrusive sensors for rocket plume properties, we propose a laser-based velocity diagnostic that does not require seedin
ase II proposal, MetroLaser and Worcester Polytechnic Institute plan to develop an extremely versatile optical inspection suite to aid in the
aser beam delivery on a remote target remains a key problem for practical implementation of tactical laser systems. Since the conventiona
osal outlines a plan to design, develop and test a prototype glass-ceramic thermal history sensor for use in extreme environments such as e
ose to develop a Stereoscopic Laser Scanner for measuring the pitch, yaw, position, and velocity of projectiles in aeroballistic test ranges. Th
ose to develop a high-speed digital streak camera to record high-resolution focused schlieren images of rocket sleds and their test articles. S
ect seeks to develop a unique instrument for non-destructive inspection (NDI) and defect detection in aerospace composite structures. The
Phase
e orderII of SBIR proposal
3.5K to develop
x 4K pixels) an extremely
and address issues ofversatile
scaling optical inspection
the technology andtool for aspheric
handling optical
the very largecomponents and optics
amounts of data that are
produced. not easi
If successfu
ymes, or viruses to pioneer new drugs to cure diseases.
ctive of this proposal is to demonstrate the feasibility of developing variable speed speech synthesis technology. We plan to use open sourc
nsformation is altering one person’s voice into another person’s voice in such a way that the source speaker’s words sound like they are the
'tf tactile displays
developed. Thisfor intra-squad
Phase communications
I application offersdeveloping
is aimed toward a number aoflife-saving
advantages: they are
product for non-illuminating and can
use in life threatening be acoustically
emergency causedcovert,
by inva
will contain an enzyme (lysostaphin) to digest bacterial cell walls and a nanocarrier drug delivery system that would make the enzyme stabl
metric threat poses perhaps the most dangerous risk to US forces and assets both overseas and at home. Because of the sheer amount of
hreats tend to maneuver in commercial vehicles through dense, cluttered urban streets where detection and tracking become exceptionally
Analytics proposes build a executive sensor resource management algorithm that (1) extends the algorithm successfully demonstrated in P
s Phase II SBIR, the Decisive Analytics Corporation (DAC) team proposes two advanced capabilities that are not currently supported in the
osal and the Phase I work completed under it addressed these NASA-identified needs by providing software infrastructure that provides ph
ality SIAP is the essential foundation of effective air defense, reliable combat identification and is the key to exploiting advanced offensive
ose a “model-of-models” approach for building a Bayesian Prognostic Failure Model that will meet Army IAMD requirements for the ASoSC2
onal statements of logic (e.g., simple statements of the form “if x then y”) allow individuals and machines to make quick and efficient deter
ignificant research, engagement management algorithms have not matured to the point of deployability - even the most advanced algorith
al War on Terror (GWOT) has amplified the need for rapid response operations, requiring the ability to support the missions through the fo
tics CourseBook Project will address three national critical issues in mathematics education the need to support standards based instructio
al War on Terrorism is increasing pressure for DOD depots to expedite the return of serviceable weapon systems to the warfighter while ma
partment of Defense (DoD) weapon systems are operating beyond their original design specifications, resulting in failures requiring unplann
and evaluates the Accessible Testing Learning and Assessment System (ATLAS), a testing and assessment system which can be used by teac
 rates the technical merit and feabisibility of Geo Talk approach for providing indepndent access to speech output functionality for individua
and tests the Visual Media Literacy System, an accessible software system with a simplifed, picture-based interface design used for accessi
es the utility of Web-Voyagaer as an online, dynamically driven information and service management program, specifically designed to del
troubling decline in the number of US citizens training to become scientists and engineers. There are insufficient numbers of qualified scie
s system to alert peope who are deaf of critical sounds and events in their environment, utilizing a new consumer product called a Bluetoo
which performs optimal
itiate longer-term face recognition
experiments on earthwormin a miniature
propagationunobtrusive device that
to make possible moreis built around a common aperture imaging camera with a
ul results in Phase II."
ry work at WSU has shown that a moving baffle can lead to enhancements in velocities and solids removal. The preliminary work, though,
ted prototypeunder
es developed of thethis moving
effortbaffle will remove
will enhance the solid
abilitywaste
of USfrom the racewaystowith
agro-businesses minimal breakage and phosphorous leaching via the inc
rapidly
o, and capitalize, on new market opportunities both nationally
FC in their effluent treatment systems while also establishing a new and relatively and globally.
ve feed source
efficiencies, andtoa livestock
comparative producers.
study of conventional controls vs microponic results to
he usefulness of this new technique."
modal
emands computer interfacehave
for red snapper device and authoring
resulted toolkit for therise
in an unprecedented development
in mislabeling of age-appropriate
and substitutioncomputer learning
of the legally for children
designated and adolesce
red snapper speci
NA-based test formats have emerged to counter this situation in the red snapper industry however these tests are laborious, costly and no
ial-scale marine aquaculture has the potential to balance the increasing demand for high-quality seafood products with the limited harves
ting systems
lications are expected
for improving to play
abiotic a key
stress role in the
tolerance expansion
in other monocotof US aquaculture
crops such as production. Recirculating systems allow year-around produ
d maize.
earning is community service performed through schools that is integrated with curriculum-based instruction and individual refection. In 2
ect is to developofYouth
ry assessment Map a software
the feasibility package and
of implementing curriculum that
an atmospheric enables
plasma highinschool
system a students to create network models of community
esting operation."
rgins in commercial catfish production continue to shrink due to increased production costs, economic infation, and increased foreign com
ect is aimed
statistics at helping
to identify protect
those SNPscrop
andproductivity
haplotypes that by providing
are mostaclosely
means of rapidly assessing the health of bee colonies used for pollination. W
d with mite resistance."
of dollars are lost worldwide due to insect and fungi caused spoilage in stored grain. We propose to develop new technology for early detec
ials have shown that early detection is feasible long before a human can smell it, or a temperature cable can sense it. Phase II is required to
deficiency
s on the final is the worldsgum
xanthan most prevalent(viscosity,
properties nutrient deficiency
molecular and causes
weight, etc.)both
will significant
be studiedadverse health
to evaluate theeffects and enormous economic loss
of producing
forests, createxanthan gum from
a new resource forglucose and galactose.
fermentation to bio-based fuels and chemicals,
roduce a new and improved MDF product."
o be widely integrated into avian infuenza vaccine strategies for both domestic and wild bird
ns.
to niche markets. All segments of the pork industry will benefit, with the ultimate
o be realized by the consumer.
enceandquality
portable watercraft
of rural transfer
life while devices
promoting that interest
public provide bysafedeveloping
access to boats
a vital,for individuals who have difficulty boarding boats, such as peop
lowcost
ystem
oal is toand reducing community
demonstrate economically spending.
attractive operation of an ethanol-extracting
bic PV membrane for a period of
statistics to identify those SNPs and haplotypesat least 500 hours.that are most closely
d with mite resistance."
osed
Phase research builds
I will adapt upon game
a video the work
from onathe Children’s
previous SBIR Progress
project toAcademic Assessment (CPAA), a computer dynamic assessment in language
test feasibility
oject strategy."
ram introduces a membrane system to remove water and stabilize BHF. The inert membrane withstands harsh thermal and chemical enviro
will integrate
l, CMS commercial
has established membrane
strong modules
relationships into
with hydraulicpartners.
industrial systems These
in laboratory
partners followed
will aid by full scale
in both field program
this SBIR tests to demonstrate a fieldcom
and downstream sys
tform
an technology
alternative and industrial
out-of-season partners,
spawning this program
method, and testshould successfully
different mid-summer enhance synthesis of natural products. This will provide value fo
fry production
es.
ed previous
results research,
are fow cells this project
that candevelops and demonstrates
process water sample for DNA the testing
HearingCompanionwhich:
of pathogenic E. coli(1) automatically
O157:H7 recognizesinspecific
and Salmonella sounds in th
1-2 hours.
evelopment can expand the number of waterborne pathogens and expand the application to testing of food, drinking water, recreational w
and defines the Lime notation software, a self-contained music reading and writing system that allows low vision musicians to accomplish
d rapid
sustainability
injectateofrates
farming and plasticulture
to achieve productionpractices
rates
e the process commercial viable
methods
vide newhave beenpotential
income developed forand testedparticularly
farmers, to estimatethosesoil water retention
participating in curves (WRC) indirectly. These methods do not always provide re
ervation Reserve Program."
on can be expanded to include other types of animal wastes (such as poultry and hog
n other
nts, and areas of the country
entrepreneurs who arewhere CAFOsnew
pursuing are patentable
in close proximity
methods to in
cement kilns.
nutrition
ure management
t currently for and
available livestock."
none of the currently used methods of evaluating for
ry disease are capable of early detection or mass screenings."
e unit will be fabricated and tested in the lab and under live CAFO conditions in
on with
ercial USDAinterested
dairies ARS staff in
in participating
Fayetteville, AR.
in Phase II
arkets compost system to diary and CAFO industries
al
rgeissues of increasing
increase petroleum
in the price prices, and
of oil, propane, the gas
natural impact
and of fossil fuelthe
electricity, consumption on climate-change,
nations farmers are paying highhave
costsrenewed national
for heating priorities
buildings. to d
The prob
ess of the Phase I research will establish the feasibility of producing, and
and weed control disks can be developed. Long-term opportunities include technology convenient use of, biomass logs on farms for heating buildings. It w
greements and
igh-pressure product
steam licensing.
reforming of the WSF to make syngas useful for making
es developed under this effort willsynthesis
rade hydrogen and other biofuel enhanceliquids."
the ability of US agro-businesses to rapidly
o, and capitalize, on new market opportunities
ity, high-value, widely recognized market that can both nationally
support localand globally."
orchard
on.
n collaboration with the Poultry Diagnostic and Research Center at The
yentof for
Georgia."
the detection and decontamination of anthrax-contaminated buildings
es.
ble to small farmers for packaging milk effectively. This will allow the small dairy
go product.
add valueThe to their products
project and help
will improve thethem to remain
viability of smallafarm
part production
of their communities."
al increase in organic production with its attendant environmental benefits,
vegetableagricultural
monitoring varieties, and a significant
resources, opportunity
combating for organic
bioterrorism, seed producers"
monitoring energy
and measuring sequestered carbon in vegetation.
ychiatry portals to serve high need communities that currently lack quality
ealth services
a fully bioelectric , portable gesturing device that translates American Sign Language into English text and audio through two different vers
ure of shrimp
success is a multi-billion
will enhance dollar
the poultry business
industrys worldwide.
ability Infection
to deliver quality,ofsafe,
shrimp
andgrown by aquaculture with the organism leading to Necrotizin
costeffective
roducts
oad salt to American
that consumers.
is already sold to demonstrate to residents that their streets have been

clear and
atalyst immediate need
semiconductor and thefor improved PRRSV
anti-refective vaccines.ofPRRS
composed is estimated
transparent to cost pork producers
semiconductors. Work on the in the U.S. nearly $600 million annually
n of the films
eveloping is integral product.
a commercial to the project."
We envision that it will broaden the
ities for Bt-based insect
ting savings to STS (if adopted) controlofbyapproximately
overcoming limitations
$40/ha orin Bt million
$50 biopesticides.
if used over the
four years.
ge generated will be widely disseminated widely across
grape
tly, growing
saving $206regions
million ofin the
foureastern
years ofUS."
eradication of PBW in
ted 1,715,000 acres of cotton."
ir and denser moisture levels. Tropical fruits normally propagate and prosper at a
ial level
ctive below
of the Phase2000 ft. altitude."
II proposal is to identify the best strategy for transferring TSV resistance from the TSV-R line to the Hybrid line, and the be
n the State of Hawaii, Kona Bay was founded in 1996 and is the worlds leading producer of specific pathogen free (SPF) and specific pathog
ance Program, a form of rehabilitation service delivery that allows for consumers with cognitive impairments (e.g., traumatic brain injury, st
onal Accessresearch
sciplinary Computer teamKey, a modified
will implement Universal Serial Bus Phase
Global Wellnesss designed to accommodate
II Pilot adaptive
Study: (1) continue softwarethe
to develop capable of being
software launched
and planning on publa
services
ial applications
will determine ifare theanticipated in the career
method is feasible centers
and will (seasonedinworkforces),
be performed collaboration military (base closures and transitioning), private companies (e
archers at the USDA-ARS
s, and quantify the productionPoultry Research
costs. PhaseUnit in scale-up
II will MississippiandState,
justifyMS."
the production costs versus the
dy biofuel price point."
Regarded As Safe) by the FDA, with a new class of antimicrobial pH modifying compounds that are
onmentally
water in thebenign.
U.S. During the Phase II project, a compact, automated monitoring system
veloped
ns, and field-tested."
Lynntechs design and engineering team, in collaboration with academic/industry experts, will
anufacture, and test a fully-optimized,
conditions, determine process feasibility,integrated
and set continuous ozone treatment system in Phase II.
targets for pilot-scale
ment in a Phase II project."
s work
of volatile
with achemicals
local group haveto been reported
complete as emissions
5 specific from local
tasks: assess confined animalresources;
feedstock feeding operations
design the(CAFOs). These
process for emissions
hydrolysis andare environmeno
fermentation
esearch
bies. A keywillconcern
result into anbeenergy efficient
addressed process
in this projectforisutilizing mixed
the safety starch feedstocks. Reduced operating costs for feedstock and energy an
of the
ant virus in target and non-target animals.
rception and understanding the spatial structure of organic molecules have historically been a source of difficulty for high school chemistry
ose increase
ms, of this project
sales ofis to produce an
market-size intelligent
oysters, and to molecular modeling kit and
supply concentrated, low software
cost, suite for advanced placement chemistry classes for real
ae to finfish and shrimp farms.
taissmall, waterproof,
estimated that 2000Warless
dairyEMG
farmsPreamp
that aresensor for myoelectric
over-applying arm prostheses
phosphorus have that transmits a digital signal via a wireless link, eliminati
istics that suit them to use of the new technology.
ial use in current pulp preparations to improve fiber surface properties for better
and
elease stronger paper."
to desired levels and methodology for incorporating NanoCide
will be developed."
em would provide a renewable, high efficiency, low emissions power
gy naturally suited to distributed generation in rural and remote locations.
 ty to utilize nitrogenous inputs more effectively, benefiting farm economics as
e rural
of environment.total system approach to produce a wide range of potential high
a patent-pending
alue products from HDRB.
pe special
3. An education
assessment of intervention
the practical called My Scrivener,
and applied aspects based
of the on emergingshelf-life,
production, research methods,
demonstrating
dosesthat
andcomputer-assisted motion
rates of application, training
and the econo
arch will involve greenhouse and field experiments taking horticultural crops to yields, studies of a much wider range of plant pathogens, p
osed buried
urer and innerduct/duct
consumer preferences.network (BIN) comprises
Successful developmentan integrated system to facilitate future upgrades of buried communications (telepho
of this technology
pplications in food and pharmaceuticals packaging.
eed, automatic book scanner to digitize large libraries of bound printed matter
y will determine the feasibility and effectiveness of the new sensors design by comparative analysis of laboratory wind tunnel and field salt
ect
atesisoftoour
develop
oystersa marketable
and musselenvironmental controller towill
crops. Other aquafarmers improve the productivity,
also benefit as we energy-efficiency and cost-effectiveness of locally prod
new
cement management
systems and techniques.
work to further improve the OvuGelTM intravaginal dosing
r.
ose a Cooperative Research and Development Agreement between Phenotype Screening Corporation, (PSC), and the USDAs Forest Services
main
onitorunanswered
would be inscientific
establishing questions as tolevel
an optimal the applicability of the device
of ethylene during for long-term tree research. The Northern Research Station, (NRS)
controlled
ng of harvested fruits and vegetables.
on Learning Media,
ill significantly reduce Inc.,
theWheeling, WV, will
environmental create aand
pollution prototype
decrease ofthe
a Virtual Physics of
dependence Laboratory
the - an online, virtual physics lab experience for
nmy on several
with the foreign
dairyoil.
equipment manufacturers. We believe potential annual
forty million dollars.
vely superior silver zeolite activated-polymer. This effort will establish
procedures for applying
d-ready multi-array future active
prototype factors
diagnostic to polymers.
device. The technology is also easily
eusfor human diagnostics using appropriate
operations that can compete against petroleum-based antibodies and diesel,
samplethus
processing
helpingprotocols.
to reduce the
ependence on foreign oil.
tion software program for hand-held computers or PDAs for deaf signers to create simple, unambigous English sentences
a low-cost and portable rehabilitation device with intelligent control to stretch spastic joints safely and repeatedly througout the range of m
ctive
on ofof this
this proposal
project will isresult
to develop
in a 100a rapid,
percent simple, and efficient
biodegradable method
stabilized to perform
media for use targeted
in homologous recombination in plants. We will p
yialtreat
forestry efforts,
colonies for greenhouses
Varroa infestation and nurseries at a competitive
with a minimum price.
cost in labor expense
ew equipment needed.
of this SBIR
marketing. project
This the proposed
is achieved commuter
by employing railcar loading
an innovative concept
business modelwas
anddeveloped
unique in detail and its operation was simulated in order to de
hip that also
objective offers
in this important
research is tobenefits
identify to lobster and
a catalyst harvesters.
operating condition, which allow these unique volatiles to be selectively detected in cr
nclusion of this project, we expect to have demonstrated proof of principle for a sensor capable of selectively determining concentrations o
4,000 Words project will develop and test a multimedia system for ensuring that students in Grades 1-4 know the meanings of the 4,000 m
4000
ons will Words project will
be evaluated develop
in an in vivoand test a multimedia
experiment system for
using histological ensuring of
evaluation that
thestudents
teat in Grades 1 to 4 know the meanings of the 4000 m
sngstimes
andpost-application.
homes, especially in rural areas. Users of the product will lower their
xpense
drink. It willalso
and reducewildlife
improve fossil fuel demand
habitat, and emissions
and benefit in their communities.
threatened/endangered
ill investigate the feasibility of this concept in conjunction with researchers at
tion Training
oduction and Research
technology Center at approach
is a well-suited Californiafor
Polytechnic University.
small businesses to produce quality nematode products. The costs of producing in vivo h
arch will lead to development of a powerful biocontrol technology for suppression of arthropod pests. Nematode production costs will dec
ose of this project is to develop a portable, affordable, classroom observation system that makes observation practical for a variety of appli
ose of this
council, project
board is to develop
member a portable
and employee affordable
orientation andclassroom observation system that makes observation practical for a variety of applic
as an educational
on mandated for board members or employees for minor
cant, Staron LLC, has developed a unique approach to rat control that ethical infractions.
focuses on species selectivity. Accordingly, the Companys approach d
Since all formulation ingredients can be obtained from renewables, a USDAfor usage in domestic agriculture and in other markets.
rior of the two products will be commercialized as a rat-selective toxicant
Alternate and Renewable
ming is growing rapidly. ItEnergy, could
will also servebenotice
met. that we are ready to open
mariculture consultation
s will be edible oil process throughout
equipmentthe andU.S. and overseas.
catalyst manufacturers, and food processing
es.
s Immersive Learning
participatory government Environment TILE is acontrol
communications, cost effective virtual
of remote reality
objects platform
and remotethat
datawill enable students to participate in simulations tied
.
has discovered that manures, and barks as well, make highly efficient oil absorption products. The oil absorption marketplace is dominate
ation of the
bjectives are user interface
successful, requirements
it will indicate that-response
autosomal time,
sexaccuracy,
reversal isand function set - needed for the Handsight cell phone service to impro
lead directly
mpliant methodto Phase II research.sharing, and entering data into
for transmitting,
often disparate systems.
 l business innovative research proposal is directed to methods for generating hydrogen using anaerobic digestion. This patent pending syst
ose for this proposal is to obtain funds to replicate the successful production of pure hydrogen in the lab where synthetic manure was used
ase IIofwe
ctive willproposal
this developisato work zone collision
demonstrate system consisting
the feasibility of "smart
of utilizing barrels"
bacterial ghostsand
(BG)a as
central
novelcommunications computer.Current
vaccines for aquaculture. The "smart barre
vaccination
ase
Fin,I farms
proposal
andthe feasibility
ranches couldofnot producing a BGtheir
only supply based vaccine
own energy forneeds
use inbut
thealso
aquaculture
harvest industry will be assessed. To determine whether th
wind energy to sell to utilities, fostering rural development.
dy of environmental water. In later phases, the unit will be developed for submersible
ent in both fresh and saltwater environments.
past
l Phase15 years the incidence
II prototype has been of made.
in-transit
Thelosses
MLM in swine
units willduring transportation
be a robust as well astoa slaughter has tripled. These losses (non-ambulatory and d
inexpensive addition to the safety equipment at the nations grain mills.
Applied Sciences Corp proposes to develop a fast pulse, portable, fast neutron source to detect SNM in the field. Our source offers a 20ns n
g complexity of encryption used by criminals presents an ongoing challenge to law enforcement agencies. Effective code breaking attack m
teamed with Lockheed Martin Missiles and Fire Control (LMMFC), will deliver a system for remote capture of biometrics for screening proc
neutron generator is proposed for the detection of special nuclear material. A recently developed RF-excited plasma neutron generator wil
approach to Maritime Domain Awareness begins with surveillance of vessel traffic as far offshore as possible to allow the advantage of tim
-Of-Life is a hydraulic rescue tool used to rip cars apart. They consist of a pair of metal claws that are used to spread/cut/rip automobiles or
cal sources are in everyday use in numerous industries. Illicit removal of this material from storage could result in construction of a Radiolo
ht portable biometrics screening tools are needed to accurately and rapidly screen and manage the identities of individuals at the scene of
e Research, Inc. proposes to design, build and test a non-contact sampling wand intended for the detection of energetic materials which wi
aryBenefits
ed objectiveand of this project isApplications:
Commercial to design and Thedevelop a rootkit
proposed detection
framework will system
providethat
the also has the capability
methodology and bestto protecttechniques
practice itself. AFCOtoSystems
capture D
osed of
ctive middleware
this effort product will address
is to design, construct,this market
and need anda future
demonstrate market growth
highly efficient and will beand
trace particulate thevapor
basis sample
for our planned
collectionPhase III private
system. Used infuc
Advanced Sample Collection System is to be designed as a universal front-end to the different trace detection technologies, it has broad co
oved surveillance of radioactive sources used in hospitals, research centers, food irradiations plants and other fully legal and sanctioned ind
nt wave of mass casualties plaguing the public safety community showed that the incident commander s situational awareness of the first r
the weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Prevention of the spread of radioactive m
nd applications of radiological sources, for power, medical, and defense applications, continuously increases with time. Illicit nuclear mater
tion of weapons of mass destruction such as nuclear weapons is a serious threat in the world today. Preventing the spread of nuclear weap
estic Nuclear Detection Office (DNDO) requires non-intrusive radiation detection equipment to identify special nuclear materials (SNM). Pr
of this SBIR program is to develop a CNT based gas ionization source to replace radioactive 63Ni beta emitter sources used in ion detection
rtment of Homeland Security and other government law enforcement agencies have identified the need for a technological capability for g
ose to develop a novel class of sensor materials based on chemically functionalized single-walled carbon nanotubes (SWNTs). The proposed
Systems is developing a novel, nonlethal method for disabling an uncooperative vehicle called the MVS, or Microwave Vehicle Stopper. Ou
osal describes a system that would expedite the lawful decryption of encrypted containers by leveraging the computational speed of field-
d at which an attack is detected is a critical trigger for all responses to follow. The accurate determination of the type of attack will determi
t proposes to design, develop and productize the Secure Inter-organizational Network Boundary Assurance Device (SINBAD). SINBAD will le
net Extraction And Response, iBEAR is a holistic solution of addressing botnets with collection, analysis, and prevention capability. The iBEA
ng Science Analysis Corporation (ESA) has developed a new stopping technology that is compact, scalable, and easily deployable. None of
ial applications beyond that defined by the topic include hidden weapon and bomb detection.
ovations Incorporated will develop the Distributed Project Safe-Cracker Network, a distributed computing environment for the existing Proj
ose to build an Intensity-Modulated Advanced X-ray Source (IMAXS) for cargo inspection systems that allows such systems to achieve 1 to 2
objective of this DHS SBIR project is to enable large-scale and economical production of high-sensitivity, solid-state, thermal neutron detec
echnologies, in collaboration with the University of Rochester s Center for Future Health, propose to develop and demonstrate a truly integ
mical sampling is most effective when both particles and vapor are collected due to the enhanced mass obtained. While vapor sampling is
t Automation, Inc. (IAI) proposes a novel peak detection and data fusion methodology for multidimensional chemical analysis. The propose
on that the proposed eye-safe LIBS system could have a significant impact in many applications such as the remote sensing of the improvis
control systems (ICSs) are crucial to the operation of the U.S. critical infrastructures, which are often highly interconnected and mutually d
unnels, whether resulting from collisions, bombs, or other sources, are extremely hazardous. Authorities need immediate notification of the
ial applications include border security and management, critical infrastructure protection, ID management systems, and global war on ter
ary objective of this project is to design and develop a rootkit detection system that also has the capability to protect itself. AFCO Systems D
tiveness of any critical infrastructure relies on its resilience to malicious modification and service disruption, as well as its ability to reconsti
 ial applications include upgraded capability replacements for common air-tube and magnetic vehicle counters. By providing detailed inform
or system will be designed to be robust enough to operate in the presence of various sources of noise such has direct sunlight, loud sounds
ends in law enforcement clearly illustrate the effectiveness of the taser to debilitate even the toughest targets, without causing permanent
portation system is an attractive target for terrorists because it could allow them to cause immediate harm to large numbers of people and
search theory is built on the concept of sweep width to determine the probability of detection (POD) for a target in a defined area. Turret-
ute;, along with ballistics and firearms expert Ed Hartwell, proposes development of the “Piezer” (pee-ay’-zer) &ndas
I, we propose to develop a full-scale prototype of a Botnet Analytics Appliance, BNA, that leverages botnet intelligence contextual knowled
osal is for the design and development of advanced high-efficiency semiconductor thermal neutron detectors in both silicon and silicon ca
dentification of chemical hazards in multidimensional datasets is a key challenge for the deployment of effective chemical vapor detection
se of hazardous chemical vapors has the potential for severe casualties, and the detection of such chemicals is therefore critically importan
oposes development of a novel combined solid-state neutron and gamma detector achieved by integrating 10B/Gd loaded neutron-sensitiv
osal addresses
fabricate sensorthe need
suites hasspecified in DHS
the direct SBIR
effect FY07.1 under the Topic Number H-SB07.1-007 Improved Chemiresistor Sensing Arrays for De
of placing
ore robust equipment into the hands of first responders.
n for this product is that it will become a standard requirement for emergency first responders. We intend the system to have an open inter
accelerators that produce continuous (DC) or continuous wave (CW) electron beams at very high repetition rates are essential for use in rap
e the amount of radioactive material in common use for commercial applications and thus improve public security, the DNDO is seeking rep
s the need for combined vapor and particulate trace explosives sampling and collection, Physical Optics Corporation (POC) proposes to dev
lopment of the NITSEW techology will increase the security of international shipping. As the shipping of palletized goods is a universal proc
s the HSARPA need for remote detection of vehicle-borne improvised explosive devices (VBIED) and suicide-bomber threats, Physical Optic
s the HSARPA need for an innovative prototype system for real-time detection of human targets in seawater, Physical Optics Corporation (P
ose a Phase II project to develop and prototype a fexible time-domain terahertz (TD-THz) instrument that can be marketed to customers cu
m will perform real-time ECG monitoring and communicate wirelessly with the Command Post on the cardiac status of the firefighter. Alert
Science, Inc. (SCS) proposes the research and development of polymers and materials for the rapid and sensitive detection of low molecula
1, a distinct probability exists that terrorist will attempt another attack with chemical or biowarfare agents. Consequently, the Department
important and unique, aspect of our work has been the development of formal metrics for comparison of biometric reliability measures an
oses developing a portable continuous monitoring system including a radiation sensor, positioning hardware, and wireless communication
e II effort
ase I SBIR will develop
project, a functional
Synkera proposesprototype
to developof and
DMnet, a distributed
commercialize botnet detection
solid-state and mitigation
neutron detectors system.architecture
of a unique Our Team will
thatdevelop and in
will enable s
-state neutron detectors are expected to have much larger neutron sensitivity and lower power requirements than conventional detectors.
ciences Inc. plans to develop specific standards for security related applications for control systems and intelligent electronic devices, which
iFi has become the de facto standard for wireless home networking, IEEE 802.15.4 is quickly becoming the standard of choice for machiner
d radioactive sources are a worldwide problem. DHS DNDO is seeking replacement technologies for non-medical orphaned nuclear devices
t, the field of mobile biometric screening devices is limited to either strictly data capture devices or devices with limited data processing an
tems, Inc. proposes a Secure Wrap technology for the containerized shipping supply chain that detects intrusion into cargo at the unit (box
focuses primarily on monitoring intermodal sea containers. The proposed solid-state detector is also suitable for other deployments, includ
ffort demonstrates feasibility of a second-generation Medical-Emergency-Vest that is low-cost, fexible, reconfigurable, smart, based on ext
Pyro, Inc.
of this proposes
project to develop
we focus a modular
on developing wireless body area
a proof-of-concept network that can
state-of-the-art forward
radiation real-time
sensor information
network about aof
for the purpose specific first zonal-bas
providing responde
ent agencies and the private sector have growing requirements to protect the general public against accidental or deliberate nuclear conta
esearch Company (ERCo) and the University of Texas, Dallas (UTD) propose the development of a novel and highly sensitive eye-safe laser-b
rap film is increasingly being used to secure palletized cargo for shipment due to its low cost and ease of use with irregular loads. IST is pro
ION (provided by applicant): The goal of this proposal is to produce a fully characterized polyurethane heart valve prosthesis that will be re
ndent manner. This is relevant to the public health by enabling greater access to medical, therapeutic, wellness, recreation and other comm
eet these transportation needs.
ION (provided by applicant): We propose to develop compact magnetic resonance imaging (MRI) systems for imaging lungs as well as othe
ION (provided by applicant): Pressure ulcers are a significant problem in long-term health care. Estimates of prevalence in the long-term an

ION (provided by applicant): Expanding use of microarray systems for global gene expression profiling is leading biological research, provid
ION (provided by applicant): We have designed a prototype lightweight, sturdy, user adjustable ergonomically designed backrest support f
 ION (provided by applicant): The generation, manipulation, storage and retrieval of chemical structures and subsequent calculation of vari
ION (provided by applicant): The Health and Retirement Study is one of the world's most important data resources for the study of aging. T
ION (provided by applicant): Proposed is the development of manufacturing processes for electrostrictive arrays allowing for real-time ultr
ION (provided by applicant): Age-related macular degeneration (AMD) is the major cause of irreversible loss of vision in the adult populatio
ION (provided by applicant): The average person in the U.S. contains detectable levels of more than 100 industrial compounds, pollutants,
ION (provided by applicant): Neural prosthetic devices are artificial extensions to the body that restore or supplement nervous system func
ION (provided by applicant): This STTR proposal to the National Institute on Aging (NIA) requests funding to expand the capabilities of the
ION (provided by applicant): This STTR proposal to the National Institute on Aging (NIA) requests funding to expand the capabilities of the
ION (provided by applicant): Carbohydrate functionalized nanoparticles, i.e., the glyco-nanoparticles, have wide application ranging from s
ION (provided by applicant): Glycomics is an emerging field that focuses on studying the interactions of carbohydrates with other biopolym

ION (provided by applicant): Conventional body-powered assistive appliances intended to help children having upper limb deficiencies hav
ION (provided by applicant): Selective antagonists of A2A adenosine receptors (A2AR) are thought to have potential for the treatment of a
ION (provided by applicant): The goals for this Phase I proposal are: 1) construction and bench testing of a novel device to dissociate tissue
ION (provided by applicant): The overall goal of this SBIR Phase I proposal is to find compounds that inhibit C. perfringens epsilon-toxin acti
ION (provided by applicant): Alterations in neurocognitive function play a major role in numerous sleeps, neurological and psychiatric diso
ION (provided by applicant): Obstructive Sleep Apnea (OSA), a highly prevalent, under-diagnosed disorder affecting over 18 million Americ
ION (provided by applicant): Intradialytic hypotension (IDH) is associated with increased morbidity and mortality and causes delays in patie
ION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending t
ION (provided by applicant): This competing continuation SBIR application proposes to complete a regulatory approvals program on a set o
ION (provided by applicant): As the population ages, chronic care becomes increasingly important. The contrast to acute care is significant
ION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a miniature portable electroencephalo
ION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a tool for pulmonologists and respirato
ION (provided by applicant): This phase I SBIR seeks to establish the feasibility of using quantitative thermography to identify the clinical eff
ION (provided by applicant): Advanced Medical Electronics Corporation proposes to develop a wireless wearable system to assess adheren
ION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a 16 node wireless surface electro-myo
ION (provided by applicant): Advanced Medical Electronics (AME) proposes the development of an indoor way-finding device utilizing the
ION (provided by applicant): A new wireless network standard called Ultra-Wideband (UWB) makes possible the creation of an ambulatory
ION (provided by applicant): Breast cancer remains one of the top three cancers to affect and cause mortality in women. Major shortcomin
ION (provided by applicant): We propose to develop a novel method and kit for profiling the expression and activation of signal transductio
ION (provided
bility to performby3Dapplicant):
perfusionApproximately
imaging of the135,000 newat
whole brain cases of non-small
conventional highcell lung cancer
resolution 256 (NSCLC) are diagnosed
x 256 matrix each
images and year in the
to perform USA,
time avey
res of blood perfusion will be useful for studies of neurodegenerative diseases, drug trials and identifying perfusion abnormalities in stroke

eration non-replicative
ment, lost productivityadenoviral vectors show
and compromised promise
quality as anti-cancer
of life due agents
to recurrence are and as problem,
a huge prophylactic vaccines.
which needs Current methodswith
to be addressed for manufact
new mor
the outcome for patients with intermediate-risk prostate cancer. This grant will enable evaluation of ProstAtak(tm), a product aimed at imp
ION (provided by applicant): Malignant gliomas have a very poor prognosis with median survival measured in months rather than years. I
ION (provided by applicant): The analysis of components in human breath is a powerful non-invasive technique for the diagnosis and mon
ION (provided by applicant): Asthma is one of the most common and costly illnesses in the US, with over 20 million Americans suffering fro
ION (provided by applicant): Malaria sickens over 100 million people each year. The vast majority of the victims live in endemic, tropical co
ION (provided by applicant): More than 25 million people in the United States suffer from neuropathic pain. Currently available drugs inclu
ION (provided by applicant): 6. Project Summary-Abstract Modern societies face a mounting epidemic that cuts across all age groups: daily
ION (provided by applicant): Millions of people suffer chronic neurodegeneration, leading to Alzheimer's disease and other dementias. Mil
ION (provided by applicant): Many human diseases can theoretically be treated by injection of healthy or engineered cells into damaged ti
ION (provided by applicant): Infection surrounding metal implants is a common and sometimes devastating cause of implant failure in a nu
ION (provided by applicant): According to the National Institute of Dental and Craniofacial Research, 86% of adults over 70 years have at le
ION (provided by applicant): Approximately 500,000 bone-grafting procedures are performed each year in the United States (Boden, 2002)
ION (provided by applicant): This proposal is for SBIR Phase I research to determine the design and feasibility of an innovative, new device
 a go-ahead to initiate clinical Phase 3 studies in cancer. The development of talactoferrin is therefore at a stage that a demonstration of its
aightforward path.
ION (provided by applicant): The role of proteoglycans and carbohydrate polymers such as heparan sulfate in biological processes are beco
ION (provided by applicant): The role of proteoglycans and carbohydrate polymers such as heparan sulfate in biological processes are beco
ION (provided by applicant): Science apathy is growing at the K-12 education level, and represents an alarming development with potentia
ION (provided by applicant): Environmental factors such as toxins and pollutants are known to have a strong correlation to the incidence o
ION (provided by applicant): This project encompasses development and testing of a concatenative text-to-speech (TTS) synthesis system k

ION (provided by applicant): AIKO Biotechnology, Inc. is a start-up biotechnology company focused on developing safe and effective therap
ION (provided by applicant): We believe a key barrier to transforming clinical research is the lack of open, integrated, transparent technolo
ION (provided by applicant): The objective of this Phase I study is to develop novel hydrogel-based tissue expanders that have delayed exp
ION (provided by applicant): The objective of this project is to transition Argonne-developed intellectual property into the commercial mar
ION (provided by applicant): Infuenza viruses are highly contagious, segmented negative-sense RNA viruses that belong to the family Orth
ION (provided by applicant): Highly-integrated and complex tissue and organ culture-based assays, such as organotypic brain slices and dis
ION (provided by applicant): Title: High throughput and high sensitivity multi-well plate reader Project Summary/Abstract: The multi-well o
ION (provided by applicant): Over 370,000 people in the US are hospitalized for traumatic brain injury (TBI) each year. In the US, the cost a
ION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful re
ION (provided by applicant): Recently, with the increase in number of new neutron sources, stationary as well as portable, there has been
ION (provided by applicant): Molecule specific targeting and improving image contrast have been recognized as important research areas i
ION (provided by applicant): Summary Lead and its compounds have been rated as one of the leading chemicals posing the greatest threat
ION (provided by applicant): LSO is generally recognized as the ideal scintillator for PET. It has high stopping power for 511 keV gamma rays
ION (provided by applicant): Positron Emission Tomography (PET) is a functional imaging technique with potential to quantify the rates of b
ION (provided by applicant): Dedicated high-resolution small animal imaging systems have recently emerged as important new tools for ca
ION (provided by applicant): Nuclear medicine imaging modalities such as single photon emission computed tomography (SPECT) and pos
ION (provided by applicant): The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimen
ION (provided by applicant): Information on the structure and function of proteins is important for unveiling biological processes taking pla
ION (provided by applicant): The "Big Idea" driving this project is that human memory is small, the body of scientific knowledge is vast and

ION (provided by applicant): The long-term goal of the proposed research is to develop a novel quantitative particle agglutination technol
ION (provided by applicant): The long-term goal of the proposed research is to develop sensitive, specific and quantitative enzyme-linked i
ION (provided by applicant): Treatment of alcohol use disorders (AUDs), commonly referred to as alcoholism, has been hampered by alcoh
ION (provided by applicant): The objective of this work is to develop dual function antibacterial coatings that prevent biofilm formation an
ION (provided by applicant): In current medical practice, breast biopsy serves as the gold standard for determining if a breast mass is benig
ION (provided by applicant): This proposal outlines a body of research to evaluate the cytotoxicity and therapeutic efficacy of radiolabeled
ION (provided by applicant): NIH sponsored cancer researchers have been obtaining promising results using molecules radiolabeled with le
ION (provided by applicant): The ultimate goal of the proposed work is to develop a compact, label free, sensitive and real-time platform c
ION (provided by applicant): Progress in sequencing the human genome has led to a new goal - expressing and characterizing the human p
ION (provided by applicant): There are an estimated one million people in the U.S. infected with HIV-1, with 40,000 new cases reported ea
ION (provided by applicant): There exists an urgent need to develop an effective, non-invasive method of detecting colorectal cancer (CRC)
ION (provided by applicant): Advanced Molecular Diagnostic Test for Neurofibromatosis ABSTRACT Neurofibromatosis type 1 (NF1) is an au
ION (provided by applicant): The goal of this phase I application is to establish feasibility for a quantitative molecular diagnostics technolog
ION (provided
scopy by applicant):
can identify and remove The overall
these objective
polyps for this preventing
thus actually project is tocolon
develop a diagnostic
cancer. However,assay forarapid
at least detection
quarter of major
of all polyps aremutations
missed oninc
ose to test a novel biomedical optics technology that could both greatly decrease polyp miss rate and also help speed-up the procedures. T
ION (provided by applicant): The long-range goal of this project is to be able to treat effectively plegic stroke victims using a novel therape
ION (provided by applicant): The importance of brain-derived G protein-coupled receptors (GPCRs) in mental function and health can hard
ION (provided by applicant): The objective of the proposed research is to develop and demonstrate Random Hand Hygiene Prompts (RHHP
ION (provided by applicant): This proposal will establish proof of concept for the use of nitric oxide (NO) as an effective treatment for diabe
ION (provided by applicant): Acute liver failure (ALF) constitutes a challenge to clinicians and scientists alike. Commonly associated with th
ION (provided by applicant): Progressive renal disease remains an unsolved challenge for the nephrologist, as it almost inevitably leads to e
ION (provided by applicant): Lung transplantation has become the mainstay of therapy for most end stage lung diseases including pulmona
ION (provided by applicant): Malignant glioma is the most commonly diagnosed primary brain cancer. Despite advances in diagnosis and th
ION (provided by applicant): Scleroderma or fibrosis of skin caused by a surplus of extracellular matrix protein (collagen) is localized in the
ION (provided by applicant): Rheumatoid arthritis (RA) is a chronic disease, characterized mainly by infammation of the lining, or synovium
ION (provided by applicant): It is estimated that the annual incidence of spinal cord injury (SCI), not including persons who die at the scene
ION (provided by applicant): This Small Business Innovation Research Phase II project is to develop robot-based content to target upper ex
ION (provided by applicant): The goal of this application is to develop imageable tumor-targeting bacteria that can cure tumors without pr
ION (provided by applicant): Hepatitis C virus (HCV) infection is a major cause of liver disease throughout the world. Existing therapies are
ION (provided by applicant): A novel bioprocess platform, involving synthesis of peptide and protein biopharmaceutical products as fusion
ION (provided by applicant): This is an SBIR Phase II proposal directed at the continued development of a diagnostic for the early detection
ION (provided by applicant): This STTR Phase I proposal is directed at the development of a topical treatment for mild psoriasis. It is based
ION (provided by applicant): Prostate cancer is the most prevalent cancer among men; and the second leading cause of cancer death amo
ION (provided by applicant): Sleep-related breathing disorders (SRBDs), such as sleep apnea, take a heavy public health toll, especially on c
ION (provided by applicant): The goal of this program is to develop novel inhibitors of human sphingosine kinase (SK) that are effective as t
ION (provided by applicant): Type 1 Diabetes (T1D) is an autoimmune disease that targets insulin secreting pancreatic beta cells for destru
ION (provided by applicant): The main objective of this proposal is to develop a novel cancer vaccine, ApoVax-SVN(tm) based on the use of
ION (provided by applicant): Various cancer vaccines based on tumor associated antigens (TAAs) or tumor specific antigens (TSAs) have sh
ION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siR
ION (provided by applicant): We propose to investigate, design and manufacture a sophisticated, pre-production protein crystal detection m
ION (provided by applicant): Applied Medical Visualizations (Medvis) proposes to create an interactive, World Wide Web based application
ION (provided by applicant): The objective of this project is to develop and test information visualization display technology that will aid cli
ION (provided by applicant): Applied Medical Visualizations L.L.C. has developed a pharmacokinetic-pharmacodynamic display (PkPd Displ
ION (provided by applicant): The objective of this project is to develop a CFD software for the grid-free simulation and analysis of the comp
ION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of de
ION (provided by applicant): Human apyrase represents a highly promising therapy to reduce ischemia/reperfusion injury which occurs in1
ION (provided by applicant): Arthropod vector control programs are dependent on timely information about mosquito activity, phenology
ION (provided by applicant): Microarrays are a powerful way to measure the impact of contaminants in the environment, and sheepshead
ION (provided by applicant): Airways can be obstructed by a variety of diseases resulting in breathing difficulties and compromised quality
ION (provided by applicant): Informed consent has become an essential component of the doctor-patient interaction. The informed conse

ION (provided by applicant): Precious liquid samples such as aqueous genomic DNA are the bedrock for immense efforts currently underw
ION (provided by applicant): An efficient drug research and development process requires the in-depth understanding of the molecular, ce
ION (provided by applicant): Cystic Fibrosis (CF) is an autosomal recessive disorder, which leads to the abnormal composition and physical
ION (provided by applicant): Zhang, Yun Abstract There are over 40 lysosomal storage disorders, and most of these diseases affect adverse
ION (provided by applicant): The aim of this project is to develop a novel 'liquid array' platform, based on Encoded Sortable Particle (ESP) t
ION (provided by applicant): The goal of this project is to develop a Colonoscopy Force Monitor (CFM), a handheld attachment mounted o
ION (provided by applicant): The clinical significance of ocular angiogenesis is enormous, due to the fact that in the western hemisphere, r

ION (provided by applicant): Monitoring the effects of pharmaceutical or radiation intervention in cancer patients is an important tool in th
ION (provided by applicant): A collaborative effort between ASL Analytical, Inc. and a research team at the University of Iowa is proposed
ION (provided by applicant) This SBIR project is in response to the call for the development of field-deployable or wearable personal se
ION: The specific objective of this STTR Phase II research and development project is to provide an optimized cellular therapy regimen for
ION (provided by applicant): Laboratory animals are often subjected to various painful surgical procedures as well as non-surgical procedur

ION (provided by applicant): The aim of this research is to develop a locus-specific DNA amplification process suitable for highly multiplexe
 ION (provided by applicant): This project seeks to develop an earphone for diagnostic audiometry with features that will significantly incre
ION (provided by applicant): The number of patients treated for antibiotics-resistant infections has increased drastically in recent years. W
ION (provided by applicant): The long term goal of this research is to reduce or eliminate deafness due to certain diseases of the inner ear
ION (provided by applicant): The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the ca
ION (provided by applicant): The broad long term goal of this work is to develop sustained release subcutaneous drug delivery systems in o
ION (provided by applicant): Pulmonary fibrosis, a group of incurable lung diseases with high mortality rates, is characterized by infammat
ION (provided by applicant): Alzheimer's disease (AD) is the most common cause of dementia in the elderly, with more than 4.5 million Am
ION (provided by applicant): Both Type I (T1D) and Type 2 (T2D) diabetes share a common pathophysiology - insufficient beta cell mass (BC
ION (provided by applicant): Every year in the US, several million people suffer serious peripheral nerve injury. Injuries to the peripheral ne
ION (provided by applicant): Principal Investigator/Program Director: Glass, Jonathan D. Project Summary/Abstract Axona, Inc. is a new sm
ION (provided by applicant): The long-term goal of this product development plan is to develop a recombinant bacille Calmette-Gu rin (rB
ION (provided by applicant): Each year in the United States at least 1.4 million people seek medical attention for a traumatic brain injury (T
ION (provided by applicant): The overall goal of the proposed R&D program is to develop and demonstrate a new approach for objectively
ION (provided by applicant): Due to improvements in obstetrical and neonatal care, and an associated decrease in perinatal mortality, as w
ION (provided
ariety by disabilities,
of different applicant): The overallmanifestations
including goal of this multi-phase SBIR
of spasticity, research
dystonia, effort
and is toas
rigidity, create a PDA-based
well as spinal cordinstrument for the comprehe
injury and muscular weakne
Adapting the BAJA for an individual user, as well as quantifocation of the performance improvement realized with its use, is achieved throu
ION (provided
prior by applicant):
to transport BCRThe
for slaughter. Diagnostics, Inc.the(BCR)
portability of has recently
complete developed
system would and patented
allow both commercial a and
technology platform
family focks for engineerin
of domestic birds to
of pathogenic AI viruses. The development of this device would allow poultry production managers to rapidly comply with OIE (World Org
ION (provided by applicant): Databases of biological sequences have proven valuable for understanding the organization of human and oth
ION (provided by applicant): The goals of this project are to develop, evaluate, and disseminate a suite of software programs that provide b
ION (provided by applicant): The goals of this proposed research project are to develop, evaluate and disseminate an Internet based (web)
ION (provided by applicant): Hispanic adolescents are at elevated risk for mental health and related behavioral problems. Culturally specifi
ION (provided by applicant): This is a Phase I Small Business Technology Transfer Research (STTR) grant application to support the developm
ION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR; R43/44) grant application to NIMH to support the d
ION (provided by applicant): More than 50% of drugs on the market target G protein-coupled receptors (GPCRs). Among the most importa
ION (provided by applicant): Neutrophil recruitment is a central component of infammation, and there is intense focus on inhibiting the p
ION (provided by applicant): There is a strong need in drug discovery for cellular assays that better predict human responses to drugs. A ke
ION (provided by applicant): Human embryonic stem cells (HuES) have the potential to generate an unlimited source of beta/islet cells for
ION (provided by applicant): The American Cancer Society estimated a total of 1,372,910 new cancer cases and 570,280 cancer deaths in t

ION (provided by applicant): Introduction: Skeletal muscle atrophy and weakness affect older adults and often lead to frailty, falls, fracture
ION (provided by applicant): The proposed project will support 'translational medicine', defined as "a basic laboratory discovery that becom

ION (provided by applicant): Reduction of carbon-carbon double bonds (C=C) is a fundamental reaction in synthetic organic chemistry. The
ION (provided by applicant): RPN Research has developed a new medical device, the Bioelectric Field Imager (BFI) which can measure the
ION (provided by applicant): The objective of this research is to demonstrate the feasibility of, and point the way toward, MRI-guided brea
ION (provided by applicant): The need to investigate and understand all elements of biological information pertinent to disease is more c
ION (provided by applicant): Aside for a vast minority of asymptomatic patients diagnosed incidentally, virtually all lung cancer patient
ION (provided by applicant): BioHelix is the exclusive licensee for the commercialization of a novel, primase- based Whole Genome Amplifi
ION (provided by applicant): The goal of this project is to develop advanced ultrafiltration (UF) devices for sample preparation that are fast
ION (provided by applicant): Mycobacterium tuberculosis and other Mycobacterium species are major pathogens around the world. They
ION (provided by applicant): Pneumothorax is an accumulation of air in the pleural cavity, often as the result of a blunt trauma causing a p
ION (provided by applicant): Infammation after ischemia and reperfusion (I/R) injury secondary to hemorrhagic shock is responsible for sig
ION (provided by applicant): Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause o
ION (provided by applicant): Space-Time Technology for Reconstructing Exposure in Cancer Epidemiology Studies. The overall objective of
ION (provided by applicant): The overall objective of this project is to develop the first GIS-based software to offer tools that are specificall
 ION (provided by applicant): Cancer Clustering for Residential Histories Abstract: This project will develop a new, comprehensive approach
ION (provided by applicant): This research will assess the technical feasibility of developing a new and unique miniature ophthalmic intrao
ION (provided by applicant): Single molecule analysis of long, genomic DNA will provide greater knowledge of genomic structural aber
ION (provided by applicant): The overall goal of this proposal is to develop a new cost-effective method for the production of high-purity p
ION (provided by applicant): We propose to develop a more sensitive, specific serologic assay for detection of Lyme disease especially earl
ION (provided by applicant): Lyme disease is caused by the spirochete Borrelia burgdorferi. This zoonosis is the most prevalent vector born
ION (provided by applicant): Kidney disease in the United States has been described as an epidemic. More than 20 million patients have ch
ION (provided by applicant): Cell-based therapies are rapidly gaining acceptance for use in treating a variety of diseases. The development
ION (provided by applicant): Arteriosclerosis is the major cause of human death and a primary concern for healthcare providers worldwid
ION (provided by applicant): The tumor necrosis factor (TNF) family cytokines (ligands) mediate diverse immune responses via the activatio
on: (Provided by Applicant) Sepsis a serious life-threatening condition resulting from a harmful infammatory reaction of the body due to ba
ION (provided by applicant): In this Phase I Small Business Innovative Research application, Bioptigen Inc. proposes to prototype a portable
ION (provided by applicant): The lack of affordable and practical HIV diagnostics, including assays to monitor HIV RNA levels ("viral load") h
ION (provided by applicant): The long term goal of the project is to develop enabling technology for the synthesis of long DNA sequences a
ION (provided by applicant): / Abstract Reporter genes are essential for accurate and sensitive gene activity measurements. Linked to DNA
ION (provided by applicant): Bio-Signal Group Corp. developed a miniature, low-power, wireless digital recording technology called digital t
ION (provided by applicant): A wide range of individuals cannot communicate by voice. Voice enabled Augmentative and Alternative Comm
ION (provided by applicant): Infammatory Bowel Diseases (IBDs), namely ulcerative colitis (UC) and Crohn's disease (CD), are chronic, lifelo
w research. In the field of substance abuse prevention, for example, meta-analyses have been used to determine the relative impact of com
program would be used to plan a new systematic review and to understand the implications of a completed review.
ION (provided by applicant): African Americans suffer a disproportionate health burden from chronic diseases and conditions such as obes
ION (provided by applicant): It has been estimated that 16% of new drugs will be delivered via the respiratory tract for the treatment of bo
ION (provided by applicant): The World Health Organization estimates that over 1,600 people die each hour from an infectious disease, ha
ION (provided by applicant): There is an urgent need for a long-term in vivo glucose-monitoring device for diabetes therapy. Diabetes is cu
ION (provided by applicant): As both initiators and executioners of apoptosis, caspases serve as important drug targets for many major dis
ION (provided by applicant): The introduction of automated planar patch clamp instruments over the past two years has increased the thro
ION (provided by applicant): This is a proposal to build and test a "Smart Telescope," a device for persons with low vision that uses comput
ION (provided by applicant): About 4 million people in the U.S. seek medical care each year for shoulder problems, with shoulder arthritis
ION (provided by applicant): Interferon-gamma is a T cell-derived cytokine that exhibits anti-viral and immunomodulatory effects on many
ION (provided by applicant): Rheumatoid arthritis (RA) is a chronic infammatory disease that causes progressive joint destruction, deform
ION (provided by applicant): This proposal describes a plan to develop long stroke MEMS deformable mirrors suitable for use in commercia
ION (provided by applicant): A rapid, noninvasive, and accurate, point-of-care device to diagnose and exclude pulmonary embolism (PE) re
ION (provided by applicant): Nosocomial (hospital acquired) infections represent one of the most severe problems facing the health care in
ION (provided by applicant): Extensive research in the past 50 years has demonstrated that Dental caries is a microbial infection caused by

ION (provided by applicant): Caldera Pharmaceutical's aim is to develop a broadly applicable, quantitative research tool which addresses c
ION (provided by applicant) Caldera Pharmaceutical's will use their unique, R&D100-award-winning Reagentless Pharmacoproteomic M
ION (provided by applicant): Caldera Pharmaceuticals uses protein fractionation techniques and XRpro technology to determine protein C
ION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss o
ION (provided
ulmonary, by applicant):
cardiac Parkinson's
and vascular Disease,
disease will the second
be studied and themost common of
performance neurodegenerative disorder, istoacompeting
the Maestro-3D compared complex multifactorial diseas
optical and non-op
nally, easy-to-use software for control, display, quantitation and integration into laboratory information systems will be developed.
le handling protocols to retain pathway proteins and advanced image analysis will enable the unambiguous detection of active signaling pa
of response, and clinical practice for diagnosis, therapy selection, and monitoring response (i.e., theranostics).
ION (provided by applicant): Dehydration poses a significant and costly problem in medical care. As an example, literature estimates that 3

ION (provided by applicant): This proposal is the Phase II renewal of an STTR award to Kardia Therapeutics undertaken in collaboration wit
ION (provided by applicant): The long-term objectives of this proposal "Long-Circulating Targeted Nanoparticles for Non-Hodgkin's Lympho
ION (provided by applicant): Cerebral oximetry is an optical method that measures cerebral tissue oxygen saturation (SctO2) continuously
ION (provided by applicant): The growing prevalence of heavy drinking and associated alcohol-related negative consequences among colle
ION (provided by applicant): Modulation of the infammatory cascade by several diverse strategies including A immunization, non-steroida
ION (provided by applicant): The ability of islet transplantation to reproducibly reverse diabetes for extended periods has been demonstra
ION (provided by applicant): Cell Preservation Services, Inc. (CPSI) is dedicated to the development of novel processes and devices in the a
ION (provided by applicant): Cell Preservation Services Inc. (CPSI) is a biotechnology corporation focused on developing new and innovativ
ION (provided by applicant): Cell Preservation Services Inc. (CPSI) is a biotechnology corporation focused on developing new and innovativ
ION (provided by applicant): Recent studies indicate acetylated-lysine is an under-appreciated post-translational modification with a poten

ION (provided by applicant): PhosphoSite(r) and the Phosphoproteome of Cancer Protein kinases and their substrates are important regula
ION (provided by applicant): The main objective of the Phase II proposal is to further develop the microfuidic cell culture array for high qu
ION (provided by applicant): Despite the recent completion of the human genome project, an ostensibly more difficult post-genomic chall
ION (provided by applicant): Despite the recent completion of the human genome project, an ostensibly more difficult post-genomic challe
ION (provided by applicant): Despite the recent completion of the human genome project, an ostensibly more difficult post-genomic chall
ION (provided by applicant): Our long term goal is to develop a universal cell-based therapy containing human myeloid progenitor cells to
ION (provided by applicant): We have found a polymer that specifically and efficiently binds to infuenza viruses. When coupled to a solid s
ION (provided by applicant): Current global efforts to confront the HIV/AIDS epidemic focus on the prevention of new infections and the c
ION (provided by applicant): Drug-induced QT prolongation is a common cardiac disorder associated with an increased risk for the ventricu
ION (provided by applicant): Prescription dispensing errors at a pharmacy are a problem on a national level, at a rate of about 4 errors per
ION (provided by applicant): Centice Corporation has developed a powerful, integrated approach to portable, yet sensitive, spectroscopic d
ION (provided by applicant): Three dimensional ultrasound imaging is one of the most significant challenges, and potentially rewarding eff
ION (provided by applicant): Atherosclerosis and coronary artery disease affect a large number of people in the United States, and is a lead
ION (provided by applicant): Although it has long been known that macrolide glycosylation is absolutely essential for antibacterial activity,
ION (provided by applicant): Epidemiological evidence points to the value of cardiac glycosides like digoxin and digitoxin for treatment of b
ION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of in
ION (provided by applicant): The Complete Blood Count (CBC) is the most commonly performed clinical laboratory test in the United State
ION (provided by applicant): Recent scientific investigations have shown that many chemicals used in plastics, pharmaceuticals, pesticides,
ION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes mellitus and a leading cause of blindness in d
ION (provided by applicant): Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness in the wor
ION (provided by applicant): Retinal vascular leakage or breakdown of the blood-retina barrier (BRB) is an early feature of diabetic retinop
ION (provided by applicant): Leptospirosis is considered to be the most widespread zoonotic disease in the world. Human disease is acqui
ION (provided by applicant): Current methods of cancer classification and diagnosis utilize mostly histological and morphological propertie
ION (provided by applicant): Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism required for the addition of CO2 to ace
ION (provided by applicant): Today, arsenic (As) poisoning is one of the major environmental threats worldwide as millions of human being
ION (provided by applicant): Preterm labor, and subsequent delivery and care of premature infants, remains a major cause of infant morta
ION (provided by applicant): This Phase II application seeks to develop TEACH (Training to Enable & Achieve Culturally Sensitive Healthcare
ION (provided by applicant): The long-term objective of the proposed effort is to develop an autonomous clinical diagnostics system for mo
ION (provided by applicant): The diagnosis of rheumatoid arthritis (RA) and other autoimmune disease is a complex challenge that combin
ION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States and is usually diagnosed in ch

ION (provided by applicant): This proposal aims to develop a new class of EEG electrodes that will significantly reduce technologist time an
ION (provided by applicant): The objective is to develop a multivariate system capable of recording, quantifying, analyzing, and presenting
ION (provided by applicant): The blood-brain barrier (BBB) is crucial for complex issues such as drug delivery, pathogenesis of chronic neur
ION (provided
dical by applicant):
students and PROBLEM:
prepare them for the There are currently
challenges they willover
face seven million physicians.
as practicing Americans Upon
living with dementia
completion andmodules,
of our most of them arestude
medical cared
The skills learned can also be more broadly applied to the treatment of all patients with substance abuse problems.
 ION (provided by applicant): Over the past twenty-five years, there has been a sharp rise in the number of children and adolescents presen
ION (provided by applicant): The overall goal of the proposed research is to develop selective muscarinic agonists for the treatment of psyc
ION (provided by applicant): Novel Intervention for Amyloid-Induced Neuroinfammation Extracellular deposition of the amyloid a-protein
ION (provided by applicant): Novel Intervention for Colitis The scope of the current proposal is to determine whether administration of an
ION (provided by applicant): Parkinson's Disease (PD) is a devastating neurodegenerative disorder that affects approximately 500,000 peop
ION (provided by applicant): Sepsis remains an important medical problem that results in over 200,000 deaths each year in the United Stat
ION (provided by applicant): Multiple sclerosis (MS) is one of the devastating neurological diseases in young adults that is pathologically ch
ION (provided by applicant): Multiple sclerosis (MS) is a devastating infammatory and neurodegenerative disorder of the central nervous s
ION (provided by applicant): The orthopedic small bone and joint device market is 1.8 billion with an 8.9% growth. Small bone and joint pr
ION (provided by applicant): The long-term goal of this project is to create a sprayable surgical adhesive which would satisfy the surgical ne
ION (provided by applicant): An adequate medical response to the threat of pandemic infuenza includes surveillance and isolation, a suffic
ION (provided by applicant): This project will develop a multimedia speech perception assessment and training system for learners of Engl

ION
ge (provided
3.21 by applicant):
log10 depletion In Phase I wecells
of contaminating exceeded
as wellall
askey objectives.
an average We demonstrated
recovery in bothcells
of 74.1% of tumor pervaporation and
from control vapor separation
samples. We believethe
thac
ple.
ION (provided by applicant): In diabetics, hyperglycemia is most pronounced following a meal due to the absorption of glucose from the G
n about the molecular mechanisms underlying cancer by revealing specific aberrations in genes, proteins, and signaling pathways. This prop
ment companies, with a goal of optimizing the clinical usefulness of cancer genomic data for drug discovery and development.
ION (Provided by applicant): The practice of evidence-based medicine requires efficient, easy to use, standardized outcome assessment pr
ION (provided by applicant) It is proposed to develop (during phase I and II) a person portable, highly sensitive and selective, broad ba
ION (provided by applicant): Pain accounts for almost 80% of all of the office visits to physicians each year (National Center for Health Stati
ION (provided by applicant): By combining several innovative numerical methods, solutions to the modified Poisson-Boltzmann equation (m
ION (provided by applicant): The significance of this project is the development of a laser assisted tissue welding technique to close cornea
ION (provided by applicant): As a rapid screening technique for anemia, physicians can pull down the lower eyelid and examine the color o
ION (provided
chnique by applicant):
that is superior Every year,x-ray
to conventional aboutand
thirty
UV thousand
methods, cases
and a of oral cancer
proprietary are diagnosed
replication in thesuitable
technique United for
States;
highfor whichproduction
volume the basic
y system makers and users. The improvement in image quality will allow radiologists and computer-aided software to make more correct in
ION (provided by applicant): The objective of this proposed project is to transform the data collection technology used to assess function a
ION (provided by applicant): People who use wheelchairs (clients), caregivers, and professional staff have identified the need for a lift devic
ION (provided by applicant): This proposal addresses the need for objective hospital quality/ cost ranking tools that are relevant to patient
ION (provided
th through by applicant):
development of anAmong thestimulation
electrical most significant goals
exercise of therapeutic
device exercise
indicated for following
quadriceps stroke are maintaining
strengthening strengthimmobiliza
during post-surgical and endur
strengthening has been shown to improve gait and improve performance of activities of daily living (ADLs). There are approximately 100,00
ION (provided by applicant): This research is designed to meet a critical need for a noninvasive, reliable, and cost-effective methemoglobin

ION
more(provided
than 1.5 by applicant):
million Dueannually,
fractures to the rapidly increasing
including numberhip
over 300,000 offractures
therapeutic
andhumanized monoclonal
approximately 700,000antibodies being developed
vertebral fractures and
and 250,000
ch should enable bone testing to be done conveniently and safely in a primary care setting. This should lead to earlier detection and treatm
ION (provided by applicant): Degenerative joint disease accounts for substantial human suffering at tremendous social and economic cost.
ION (provided by applicant): The ultimate aim of this proposal is to design improved therapies for malignant melanoma. This proposal will
ION (provided by applicant): We have cloned and sequenced a novel cytochrome P450 (CYP) designated CYP4X1. The CYP4X1 mRNA and p
ION (provided by applicant): Cell therapy using cells capable of generating or repairing functional blood vessels has the potential to treat a
ION (provided by applicant): Biomedical research continues to expand the use of detailed atomic-scale structure in developing a detailed u
ION (provided by applicant): The purpose of this Phase I Small Business Innovation Research (SBIR) proposal is to develop Supporting Trans
ION (provided by applicant): The purpose of this Small Business Innovation Research Phase I proposal is to develop Confict Resolution for
ION (provided by applicant): Trichotillomania (compulsive hair pulling), or TTM, is characterized by the recurrent pulling out of one's own h
ION (provided by applicant): The purpose of this Phase I Small Business Technology Transfer (STTR) proposal is to develop and evaluate the

ION (provided by applicant): The purpose of this Phase II Small Business Innovation Research (SBIR) proposal is to continue the developme
ION (provided by applicant): Multilevel data are very common in sociological, behavioral and biomedical researches. The data could come

ION (provided by applicant): Generations of patients with cystic fibrosis (CF) have spent their childhoods fighting for breath and losing. Unti
ION (provided by applicant): A diagnosis of Borderline Personality Disorder (BPD) in one person impacts the entire family. Disruption of fam
ION (provided by applicant): In this Phase II SBIR grant, Danya International, Inc., continues the development and evaluation of Making Sm
ION (provided by applicant): 7-butyl-10-aminocamptothecin (BACPT) and its water-soluble dipeptide pro-drug, are novel camptothecins th

ION (provided by applicant): Develop and evaluate an evidence-based, user friendly, and culturally sensitive training module, "Dementia C
ION (provided by applicant): Small Area Demographic Estimates for China with Remote Sensing, GIS and Spatial Modeling China is experien
ION (provided by applicant): This effort is aimed at developing an effective, easily utilized, and unified system for performing periodontal m
ION (provided by applicant): Responsible beverage service (RBS) training originated some quarter century ago to prevent driving under the
ION (provided by applicant): Oral health is viewed as an early warning system of potential systemic and mental health issues, such as oral m
ION (provided by applicant): The intent of the work presented in this proposal is to counter the worldwide health problem brought on by t
ION (provided by applicant): The proposed project will develop a data system to assess the health and other characteristics of local 60 plus
ION (provided by applicant): Diagnostics for the Real World, Ltd. (DRW) aims to market a high-performance rapid test for hepatitis B virus (
ION (provided by applicant): In the United States in 2002, over 20 million people had diabetes, which contributed to over 224,000 deaths a
ION (provided by applicant): Differential Proteomics, Inc., is developing a new proteomics technology for comparing the protein compositi
ION (provided by applicant): A practical system to remind and assess medication adherence of patients with HIV/AIDS will be designed. The
ION (provided by applicant): SPIMA: Signal Processing for Individual Mood Assessment The phase I objective of SPIMA is to create a phone
ION (provided by applicant): Kinases mediate the biological actions of neurotransmitters, hormones and growth factors and because of the
ION (provided by applicant): Cell surface receptors mediate the biological actions of growth factors. Most growth factor receptors are activ
ION (provided by applicant): Discovery Genomics, Inc. is focused on development of the Sleeping Beauty (SB) transposon system as a non-
ION (provided by applicant): Fanconi anemia (FA) is a rare, autosomal recessive inherited disease caused by the absence of any of eight diff

ION (provided by applicant): Noise-induced hearing loss remains one of the most common industrial diseases in U.S. The monetary cost of
ION (provided by applicant): Parasitic filarial nematodes causing lymphatic filariasis and river blindness (onchocerciasis), infect over 140 m
ION (provided by applicant): We propose to develop a next-generation, highly fexible optical system for use in a whole- slide scanner to ra
ION (provided by applicant): Oligonucleotide probes and primers are a crucial component of most diagnostic assays used for detection and
ION (provided by applicant): The broad, long-term objective is to develop and market a system of three- dimensional radiation dosimetry f
ION (provided by applicant): The goal of this project is to develop a series of ultra-high-performance, double-tuned, cryogenic, cost-effecti
ION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclea
ION (provided by applicant): Alternative polymeric materials will be applied toward new products compatible with 5, 3, and 1-mm tubes u
ION (provided by applicant): We are developing a high-resolution, low-dose, direct-conversion x-ray detector for intraoral Dental radiograp
ION (provided
livery by applicant):
studies. We The goal
are developing novelofin-vivo
the project is to develop
combined the nexttomography
x-ray computed generation CT detector
(XCT) modules fortomography
and fuorescence x-ray CT scanners based on
(FT) system. Thi
bilities and will benefit preclinical studies of cellular therapies.
ION (provided by applicant): Cerebral autoregulation that maintains perfusion in response to fuctuations of systemic blood pressure (BP) i
ION (provided by applicant): The broad objective of the proposal is to test whether E. coli hosts genetically altered to support complex nat
ION (provided by applicant): Echemics proposes to explore the feasibility of an innovative technology for the diamond machining of the m
ION (provided by applicant): Accurate assessment and tracking of infant body composition is useful for evaluating the amount and quality
ION (provided by applicant): Localized infection is a frequent complication of chronic wounds that interferes with the healing process and c

ION (provided by applicant): Mycotoxins are toxic compounds produced by fungi that contaminate crops during growth, transportation, or
ION (provided by applicant): Human periodontal disease is a chronic condition that results from bacterial infection of the gingival and the a
ION (provided by applicant): A New, Low-Cost Production Method for a Human Anti-HIV Protein SUMMARY: The human secretory leukocy
ION (provided by applicant): One of the largest bottlenecks in high-throughput protein structure determination (structural genomics) and i
ION (provided by applicant): The purposes of these Phase I and II projects are to test the feasibility and efficacy of using an interactive mul
ION (provided by applicant): A new method is proposed for sequencing a single DNA molecule via direct electronic measurement of individ
ION (provided by applicant): Ion channels are the control mechanisms of an enormous range of biological functions. Medical researchers a
ION (provided by applicant): Principal Investigator: Graf, Karen Abstract Home schools represent an underserved market that is rapidly exp
ION (provided by applicant) An inexpensive disposable sensing element that is worn as a vapor exposure monitor or used for urinalysis
ION (provided by applicant): The development of a new technology for reagentless multiplexed determination of protein concentrations in

ION (provided by applicant): The overall goal of this Phase II project is to develop a novel R1-based method for MRI quantification of posti
ION (provided by applicant): We will develop and evaluate a tool designed to support the collection of rich data for performing a Functiona
ION (provided by applicant): The objective of the proposed research is to identify new antibiotic lead compounds with high potential for d
ION (provided by applicant): The need for the continuous monitoring of blood pressure in patients undergoing dialysis is steadily increasing
ION (provided by applicant): The proposed Web-based Training on Core Skills for Evidence-based Prevention Practice project addresses an
ION (provided by applicant): Development of a Web-based Analytic Tool for Strategic Prevention Planning This Phase I SBIR proposal focus
ION (provided by applicant): Voice Gestures (VG) is an application that gives AAC users the ability to say what they want to say in a way the
ION (provided by applicant): In 2005, 72,000 women that underwent breast surgery had to have a second re-excision surgery due to incom
ION (provided by applicant): Brain and spinal cord arteriovenous malformations (AVM) are defects of the circulatory system consisting of a
ION (provided by applicant): The prevalence of intracranial aneurysms is about 1.6% in the general population; with a rupture rate of appro
IONand
lls, (provided by in
advances applicant): Soft x-ray microscopy
imaging technology such as theshows
abilityenormous promise as
to study individual a technique
damaged DNA for imaging
strands, cellulartostructures
combine provide a at resolutions
uniquely powerw
m Facility for Small Laboratories.
ION (provided by applicant) The proposed project will develop and demonstrate a personal exposure monitor which combines a novel
ION (provided
aims by applicant):
of the project include theThe goal of and
synthesis this characterization
Phase II programofis the
develop, testsorbent
polymer and produce a prototype
layer in addition tofield
the analytical instrument
characterization for elect
of sensor per
ion workers who encounter this gas on a regular basis in the chemical industry. Furthermore, the sensor platform can be readily
ined. Phase I results will prove the feasibility of developing a stand-alone personal exposure monitor during Phase II. The personal monitor adapted fo
rate monitoring will allow workers to identify and avoid dangerous situations. Integrated data-logging capabilities will provide employers, r
ION (provided by applicant): The Entertainment Science & Virtual Heroes Joint Venture seeks to develop a touring museum exhibit featurin
ION (provided by applicant): Antibodies that distinguish common Rh specificities cannot be induced in normal mice. Our hypothesis is that

ION (provided by applicant): Respiratory screening and diagnosis are important in today's health care. Asthma and chronic obstructive pulm
ION (provided by applicant): The rabbit is a good animal model for the study of many human diseases because of its anatomical, genetic an
ION (provided by applicant): More than 850,000 myocardial infarctions (MI) occur in the US annually, 300,000 of which are recurrences, ca
ION (provided by applicant): In Phase I of this project, Trellis Bioscience, Inc. has validated a proprietary screening technology for multiplex
ION (provided by applicant): The overall goal of this project is to evaluate the effectiveness of using a novel, highly concentrated, immunog
ION (provided by applicant): Description Dry eye is a ubiquitous, often overlooked, under diagnosed and poorly understood affliction of th
ION (provided by applicant): The genesis of cancer involves several genetic changes that culminate in uncontrolled cellular proliferation. Im
ION (provided by applicant): The current need for routine measurement CD4+ cell counts of HIV-infected individual's is immense. Currentl
ION (provided by applicant): This new Phase I SBIR proposal addresses the continuing worldwide need for a tuberculosis (TB) vaccine. We
ION (provided by applicant): Hemophilia A patients are prone to develop inhibitory immune responses to the very therapy they require: Fa
ION (provided by applicant): Assembly of proteins, drug interactions, and substrate recognition are a few of the vital physiological interacti
ION (provided by applicant): Ethanol is one of the most widely consumed drugs with resultant profound consequences to individuals and
ION (provided by applicant): Principal Investigator/Program Director (Last, First, Middle): Abstract We propose to design and deploy a hand
ION (provided by applicant): Atherosclerotic cardiovascular disease results in close to 20 million deaths annually. The hallmark of the disea
ION (provided by applicant): According to the Drug and Market Development Report (2003) 30% of research spending in drug developmen
ION (provided by applicant): Many reconstructive craniofacial challenges are characterized by a lack of soft tissue 'fill' and/or symmetry. Sp
tion that simulates 2D array, modify firmware and software of the present system to enable dual modality operation and correlation of the
r. Successful accomplishment of the proposed project will motivate our investors to engage in the commercial development and the proces
ION (provided by applicant): During the last decade, increasing interest has developed in fatty acid synthase (FAS) as a potential diagnostic
ION (provided by applicant): A type of metabolic engineering described in this proposal, and referred to as "industrial" metabolic engineer
ION (provided by applicant): Fermalogic recently discovered that the key erythromycin precursor, methylmalonyl- CoA, is the limiting facto
ION (provided by applicant): Jaundice occurs in approximately 60% of newborns. When severe, the elevated blood levels of bilirubin (hype
ION (provided by applicant): According to the American Diabetes Association, there are more than 16 million people in the United States w
ION (provided by applicant): The proposed research will develop dynamic combinatorial chemistry as a new and innovative strategy to allo
ION (provided by applicant) Airborne particulate matter (PM) derived from a variety of natural sources (volcanic activity, forest fires) is

ION (provided by applicant): The goal of this project is to demonstrate that speech translation technology can be used to remove language
ION (provided by applicant): Tissue engineering aims to create functional biologic prostheses by suspending dissociated cells into a biodeg
ION (provided by applicant): The long-term goal of the project is to develop new methods for (1) preparative scale syntheses of high purity
ION (provided by applicant): Phase 2 Application: 1 R43 GM075509-01 Principle Investigator: Khine, Michelle High Throughput Intracellula
ION (provided by applicant): In spite of many seemingly positive trends in U.S. educational settings, many children are still not succeeding
ION (provided by applicant): Glaucoma, a widespread, chronic disease, is a leading cause of blindness. In the most prevalent form of glauc
ION (provided by applicant): Human Immunodeficiency Virus (HIV-1) represents a global threat to public heath and an unprecedented cha
ION (provided by applicant): Miniature Low-Noise High-Quality MRI Preamplifiers Abstract As a start-up high-RF-technology company with
ION (provided by applicant): The indications for androgen therapy has expanded such that today, androgens are used in both men and wo
ION (provided by investigator):This is a Phase I Small Business Technology Transfer (STTR) grant application in response to Pharmacologic A
 or governments, companies, institutions. Therefore, there is a need for tools and techniques that will provide situation awareness of the c
hese “acoustic mapped metamaterials” (AMM) is novel: by careful design of their elastic properties, a coating made of AMM materials guid
n these finite element results, we proposed and demsonstrated a simple robust concept for a passive penetrator sensor that identifies the
ew design concepts, allowing quick selection of appropriate candidate designs for further evaluation. This will reduce overall design costs a
tric actuators for use in Pulse Detonation Engines (PDE). PDEs offer the potential of fuel efficient high thrust engines for Naval use, yet have
signal processor implemented on the company's DataFlowDSP(TM) hardware platform, an interconnected network of FPGAs and embedde
sk for external loads because of the more complex loading waveforms which include multiple refections in the shock phase followed by a l
erceptor communication systems: Advanced Interceptor Data Link (AIDL). The waveform signaling format will support four critical receiver
on system using identity-based security that can meet NSA approval. The system uses an in-band key distribution design enabling secure u
key tribology parameters are identified to link mechanistic failure processes with engineering design parameters. The evaluation of advan
bioluminescence risk detection aid (BRDA) for underwater vehicle navigation and mission planning. The purpose of the BRDA is to provide
CM) and basic research will be developed. Our approach is to develop a nominally expendable SWAN (Surfzone Water Attenuation Node)
oys cluster management techniques and ad-hoc networking to provide a readily scalable architecture with which to perform comprehensiv
quent changes in the propagation environment. Periods of connectivity interspersed with periods of link outages occur with durations bein
control software development/integration typically result in a lengthy and expensive integration process. Problems are frequently discove
ure of the Thermal Barrier Coated (TBC) turbine blades in the hot section of the gas turbine engine 2)Measure temperature at specific loca
d in the manufacture of consumer wireless communications devices, offers a major cost reduction methodology that should lead to the re
ed. The approved designs will be used to produce test lengths of sample ropes. The sample ropes will be tested to evaluate the performa
lnerability, related exploits appear. Furthering the problem, virus protection methods are becoming less effective in detecting or respondin
is proposed. This igniter generates a continuous high temperature oxygen plasma and offers a non-toxic approach to rocket ignition using
uppression in the wings and avionics bays because of cost and weight. Williams-Pyro will combine its expertise in fire detection, wireless te
battery power and capable of being embedded in data collector nodes for deployed sensor arrays, sensors, and other applications where ve
d increasingly strain the logistical support system and put soldiers at risk by running fuel convoys to meet the resulting increased electrical
sors and stand-alone security devices. These current surveillance systems are often point solutions based on a centralized architecture for
tion systems to provide effective translation of structure architectures into object oriented architectures.
for troops transported in helicopters. A low-profile retractable energy absorber concept will be developed. The crash performance of troo
ne ISR platforms to design new FORL systems capable of meeting RF performance requirements of systems on a next generation airborne I
nd RF signals. This design utilizes advancements in FGPA technology, A/D, D/A, and storage circuitry to create a Wideband RF recorder with
ss the issues such as good thrust/weight ratio at small size, low toxicity propellants, and will demonstrate an increase in performance and m
a propellant combination. Nitromethane has a density of 1.14 and the amount of low density oxygen needed for stable combustion is very
shear and aerodynamic effects. These losses are generally referred to as “windage loss.” In some specific, high speed machines of particul
nt proposes to design and develop a comprehensive Software Defined Radio (SDR) tool suite to aid in the development, porting, integration
elopment program to implement AFRL/VA Operationally Responsive Space (ORS) technologies including ground demonstrations and other
y component for augmented reality (AR) and virtual reality (VR) based simulation, training, exercises or mission rehearsal applications. The
sition. The combination of a proven, multi-formalism modeling tool offers a unique opportunity to improve upon the state of the art of sec
werful abstractions that permit separation of concerns. Current methods consider systems in total at the implementation level and the res
ons to deliver dependable solutions for mission critical capabilities. When considering the application domain, safety, dependability and sy
al time target detection and compression of the hyperspectral data is proposed. The system is designed to fit within the size, weight, and p
y of UHF SATCOM resources. The technical objectives of the Phase I efforts are: • to investigate analysis methodologies concerning UHF SA
mmunications systems’ performance with respect to achieving maximum data rates for a given set of SATCOM terminals. The toolset will acc
mes and a portable measurement tool is needed for regulatory compliance. Passive imaging techniques for opacity measurements unfortun
en ocean remains a significant problem. Ship-based upper air stations provide synoptic observations but also act as homing beacons for the
borne network composed of heterogeneous waveforms. The technical objectives of Phase I are: • to investigating potential IntServ signalin
f operation at expanded temperature range to meet the demanding requirements of naval aircraft. YTP, in collaboration with the Universit
n system suitable for military operations. This system will take advantage of Yotta's existing expertise in several areas: inertial and differenti
igation and communications system suitable for military operations. This system will take advantage of Yotta’s existing expertise in several
E plume located at the government-designated site. This Phase II process specifically will allow our project team to refine and complete de
sensitive signal exploitation receiver. ZA proposes to pursue development of a novel proprietary multiplexer technology to achieve that ob
gh-speed printing techniques combined with classical powder metallurgy processes. The particles produced are the feedstock for high kin
wer amplifier that are each independently agilely adjustable in bandwidth and center frequency from VHF to L band. The technique offers
eband Networking Waveforms transmitted at UHF as well as legacy waveforms transmitted at VHF and UHF. The technique has minimal im
ide batteries operate safely at specific energies higher than 100 Wh/kg, energy densities over 600 Wh/l. The olivine-type phosphate catho
om overdriving and desensitizing a cosite sensitive signal exploitation receiver. ZA proposes to pursue further development and integration
nergy system ideally has a large amount of energy with a very low weight. This equates to a high specific energy (Wh/kg). Lithium-air batter
nce to the Navy and the society at large. A promising way to remotely detect the currents is through variations of backscattering strength o
vice for Unmanned Air Vehicles (UAV) by developing a high energy density lithium-air battery with the new radically designed cell develope
o a more diverse range of aircraft and applications. Currently the STV has been fully tested and operated on a Twin Otter. During Phase I ZA
m Yb fiber laser with a tilted optical pulse wave-front to excite a nonlinear optical crystal (such as, LiNbO3) as the THz emitter, and a balance
g over a wide Field of Regard while reducing the size, weight, and power by 10 – 100x compared to conventional scanning technologies, ma
nalysis and prediction for aircraft control surfaces at various trim conditions and subjected to gust/pilot commend excitations. In phase I, a
der-modeling-based procedure as well as direct numerical simulation capability for nonlinear aeroelastic design/analysis of air-vehicles and
(ADRWD) was built and a conceptual demo at a small airport was successfully conducted. The Phase-II main objective is to refine the Phase
cal gases, biological aerosols, and explosive vapors. Unprecedented sensitivity will be achieved by differential intracavity laser absorption s
elopment of this cell will provide the Army with the highest energy density commercially available for years to come. This advancement in
tions based on a novel, ultrasafe, high-energy, low cost nano-cathode material that is capable of fast recharges and high-rate discharging. T
ent Braking Technology STTR to develop a replacement for the Navy’s high maintenance water brake. During Phase I, AMT and the Univers
ompromised by materials defects. Recently, ARI has demonstrated during its UV hydrogenation process that deuterium effectively ‘decora
arch has demonstrated that protecting a diver’s torso, arms, and legs in cold water diving without simultaneously providing adequate therm
tal voice technology prototype using an industry standard Voice over Internet Protocol (VoIP) architecture. In addition, the contractor shal
arrays. An adaptable brass-board system that is readily reconfigurable to operate advanced FPAs is proposed. This rugged system permits
lity while minimizing impact on area overhead, power consumption, and electrical performance degradation over indigenous libraries. The
adar (FL), and have demonstrated operation of the integrated device: a PLADAR (Polarimetric Ladar). Furthermore, we have performed a d
of laser decoating processes by detecting the coating as it is being removed. The technology allows for precise and selective removal of th
meal preparation, sanitation, or hygiene. The heater will react air and JP-8 in an enclosed fow path and transfer the heat generated to wa
unmanned and unsupervised refueling of another USV. The concept uses an optimized boat design, light-weight low profile crane, boom en
ystem. MDA is investing heavily in technologies that enhance producibility/operability of LWIR/VLWIR infrared focal plane arrays (FPAs), an
proposed for application as a hydrogen generating material for Army soldier-portable fuel cell generator requirements. The hydride is therm
ness appears to be a mismatch between ocular cues and vestibular cues. This is especially apparent in simulators that do not utilize a moti
nd impedes stealthy land operation which places military personnel at high risk of detection by adversaries. A dominant contributor of the
imb within a prosthetic socket is a primary concern for many amputees. A poor fit can lead to skin irritation, tissue breakdown, and pain. T
associated with the thermal deicing system. Of greatest concern is the overheating damage. An elastomeric boot offers lower weight, fexi
rently deployed troops face several severe illnesses such as Leishmaniasis and Sand Fly Fever Virus that are transmitted by insects. There a
gher ranging from minor neck strain to cervical vertebral fracture. Lighter helmets were developed and implemented in hopes of reducing
ary forces. Current DoD protocols call for the use of oxidizing agents such as sodium hypochlorite and other mixed oxidants to neutralize p
, a proteinaceous pathogen lacking nucleic acid. Prions are actually a misfolded variant of the normal mammalian prion protein, PrPc. Norm
allenge to the intelligence and military communities. The proliferation of non-tracked, illegally trafficked nuclear materials in particular has
e force. To achieve accurate, secure, and reliable wireless communications in such systems, the information fow between any two commu
rably in the last two decades. Airborne noise can be blocked or reduced to the point where the limiting factor in the intensity of sound exp
mber of creative ideas. (a) A turning table, as the base of the entire structure, allows the seat to turn around by any degree. (b) A retractable
the harsh space environment. Adhesives used in space must exhibit near-zero degassing, tolerate drastic temperature changes and be har
ter image. Sometimes the original source data used to create the map is available, but more often than not this information has either bee
ed capability for feature-aided tracking, detection and ID of Moving Targets using SAR. This effort is concerned with single or dual receiver
rgistic Composite Conductor (SCC). IST's novel SCC technology enables small cross section electrical conductors that can be printed on or e
 current method for generating these materials yields a product frought with a high concentration of ballast aptamers. A laborious, yet auto
l environment. An innovative solution is required to address the competing requirements of ballistic protection, airfow performance, and
and Circular Electrically Scanned Array (CESA). There are a number of alternative solutions which will be traded off in Phase I. The baseline
can traverse a given terrain, when the state of both the SUGV and the terrain are not known exactly. In Phase I, we developed Monte Carlo
on and Impact Technologies, LLC, is to simplify and accelerate the analysis process which creates information from the data generated by st
have proven to be extremely dangerous, from IED incidents at the top of the list of potential threats, to RPG and mortar attacks, small arms
y active, weighed down by numerous pieces of armor and equipment, and serve in warm, dry climates. While each carry a supply of liquid
nd reduce equipment loss. Electronics subsystems are critical components of modern weapons systems and are extensively employed thro
y more solid training of fight crew. With an eye to the requirements of the newest aircraft, which provide fight sensations and maneuvers
his erosive wear reduces engine efficiency and thrust. Repair/replacement of these components is costly, both in terms of mission readines
or system that can be mobile and self sufficient is required. IST’s Phase I findings indicate that our energy harvesting approach is viable and
s, such as ambient electromagnetic (EM) noise and inconsistent access to satellites or reference stations (such as vehicle mounted locators
ersonnel participating in Security, Stabilization, Transition, and Reconstruction (SSTR) missions who are untrained in social science research
geable battery for the very high altitude, very long endurance solar aircraft. Recent progress in the application of non-aqueous electrolyte
made radiation threats such as lasers and other directed energy weapons pose a different danger entirely. Solar cell arrays can be disabled
ount helmet mounted devices (HMD) such as night vision goggles (NVG). However, aircrew fying air mobility and air refueling aircraft do
cement architecture that, after pressure infiltration casting with molten Al alloy, results in materials with thermal conductivity (TC) controll
cement architecture that, after pressure infiltration casting with molten Al alloy, results in materials with thermal conductivity (TC) controll
Ds) to treat infammation and pain with reduced GI side-effects. In Phase I studies using a number of in vitro systems monitoring the activit
posed. Based on nickel nanostrand technology, these coatings, composites and elastomers will extend both the frequency breadth and dec
ountermeasure, materials superior to currently used brass and graphite fakes are required. Nano-thick metallic fakes have recently been
dvanced solid oxide fuel cells are theoretically capable of converting over 60% of the energy available in the fuel (based on the fuels lower
ountermeasure, materials superior to currently used brass and graphite fakes are required. Nano-thick metallic fakes have recently been d
materials indicate Verdet constants with magnitudes ranging from that of YIG to that of BIG. Verdet constant measurements and waveguid
op next generation EO modulators based on photonic crystal (PhC) waveguides and stable functional polymeric materials that would provid
Department of Defense. Oil debris monitoring (ODM) has been shown to be effective as an early indicator of engine bearing faults. On a co
any different assay systems for subsequent detection. The method needs to produce nucleic acids from spores, viruses, bacteria (or vegeta
f sensitive and precise monitoring of gradual subsystems degradation. The objective is to first ensure mission reliability, while extending th
wers, well beyond the currently developed electric propulsion thrusters. Based on recent laboratory results on the formation and accelerati
uation to prevent eye damage at incident radiation levels that would otherwise cause retinal injury. High transmission (>15%), high on-stat
) camera technology with dual imaging lenses placed just above the operator’s eyes, and fused with a thermal long wave infrared sensor (L
within the intercepted threat. Knowledge of warhead type is essential for effective consequence mitigation and determining the National C
problems involving compressors, synchronous motors, and turbine engines continue to threaten testing operations and maintenance budg
ogram to facilitate the development of a SDR development kit based on the Hyper64 processor with an accompanying software developme
llows lower weight rotors with decreased drag and improved compressor efficiency. Repair of these parts however is currently problemati
ning and understanding of complex social contexts. The skills set defining this critical thinking capacity would allow soldiers to respond eff
many standoff engagement options such as the use of multiple projectiles and thus cannot validly drive new defense technology developm
ligomeric Silsesquioxanes) coating that performs the multifunctional needs of a conformal coating that actively mitigates tin whisker growt
avigation and sensing. As the use of electronic devices on the battlefield increases, so will the need for electrical energy independence. At
o develop the associated analysis models remains a challenging and time consuming task. While many meshing tools are currently available
e war-fighter. In this effort, a multi-physics suite of tools will be developed based upon the successful Phase I research to provide a compre
e, predict and manage impending failures in a rotating electrical machine (e.g., aircraft generator) using a real-time, sensory-updating resid
ength and optically transparent glass ribbon reinforced polymer matrix composites as light-weight structural components, by layering and p
o stream and identify all instances of visible pedestrians. To address the problem of pedestrian detection, we will employ data-driven appro
al batteries that are suitable for gun-fired munitions and mortars. As part of the Phase I efforts, systematic methods have been developed fo
ting and characterizing IEDs. At low frequencies (below a few kHz), an EMI sensor is a magnetometer that primarily responds to susceptibil
es to automatically transit between the network landscapes. In Phase I, we have shown that our approach can deliver low packet loss, low
 tric, directive antenna array comprising advanced single radiating elements that were demonstrated in Phase I. These single quasi-volume
ilt and demonstrated for use in military environments. The system will be scalable and able to provide management and visibility in local, r
data from these studies into ground soldier simulations is slow. Modeling these effects in a ground soldier simulation is important, because
ter other than those pallets that are tagged with Radio Frequency Identification (RFID) tags in compliance with the current DoD mandate fo
ble, NIR, SWIR, MWIR and LWIR bands. Magnolia as part of the proposed Phase II SBIR Program plans to design, model and develop carbo
am goals. New hydroxy-terminated oligomers for use in polyurethane binders have been synthesized under Phase I that provide performan
geologic evaluation. Tools to acquire these cores must be light weight, draw minimal power, and induce low loads on their robotic platform
m long-range, long-endurance missions. The system, known as the Energetically Autonomous Tactical Robot (EATR) ™, obtains its energy b
ntum interference filter (SQIF) technology which will lead to a significant reduction of SATCOM antenna cost, size, weight, and power (SWaP
els of both known healthy and known unhealthy battery packs. In Phase I of the NOSTRA program, we demonstrated that this model-base
ned aerial vehicle. The system is a linear phased array, pushbroom system operating in the W band. In full Stokes mode, the predicted NED
ated inertial igniters that operate without any external power for miniature thermal batteries that are suitable for gun-fired munitions, mo
emperature prototype to a full system which can operate at temperatures in excess of 2500 degrees Fahrenheit. This project will fill a dram
transmitted by arthropods. The arthropod traps used for vector surveillance perform better when baited with carbon dioxide gas (CO2) in
educing the recover time by 20 min might decrease the cost of a patient's stay in the PACU by 110 and reduce the risk of post anesthesia c

man consumption markets for this species. Unfortunately, populations of smelt have been in decline in the Northeast for decades and in 2
made possible x-ray event streams with input count rates in the range of 1-10 Mcps. Modern digital pulse processors are therefore require
4 (KTP) or LiNbO3 (LN) or Stoichiometric LiTaO3 (SLT) periodically poled waveguides and an 1800nm pump for a high efficiency single photo
marinized Unmanned Aerial System (UAS) that can be operated easily from small or large vessels and is capable of reliable and repeatable
Today, there are more than 60 different propagation loss models available; no single model is the best in all cases. Choosing the appropriat
spectral projectors. An IR spectral projector produces programmable spectra by dispersing light onto a programmable array, currently digit
kosky at NIST during the 1980's. His initial work will be extended by this Phase 1 project to allow for a new state-of-the-art product design a
osals for adding syntax for integrity constraint axioms, to the Web Ontology Language standard, OWL. Further, we propose to implement a
ms and measure the scattering coefficient of atmosphere aerosols. The Phase I activity will be a proof of concept study that evaluates the re
ond the concepts of traditional electronic data logging animal tags. These will include functions such as communication between SeaTagT
e and degrades the frequency stability by two to three orders of magnitude.
cations, new approaches must be pursued. One approach is the rapid readout of individual nucleotides as a single strand of DNA is drawn t
e refreshable tactile graphical information to the visually impaired, enabling them to compete on a more equal footing in the workplace an
nanowires with high polytype integrity. SiC nanowires will be grown in a modified commercial high-temperature CVD reactor, used by indu
the use of closed circuit mixed gas rebreathers (CCRs) is being considered. As there currently are no sensors to detect CO2 levels in the br
brating Profiler (CLASP) system capable of autonomous operation for one year. The feasibility prototype also incorporated two-way teleme
For this effort, we propose developing an intuitive software interface for sound propagation modeling. This will be based on software dev
ors, achieving hold times for one week at temperatures below 100mK.
m as well, as the electronic acoustic sensor are intrinsically prone to degradation from salt water, as metallic conduits are necessary. These
pecies. Phase II research addressed this need. Broodstock manipulation will strive to extend the natural spawning season and, increase sp
elevated-temperature resonating crystal balance with nanogram sensitivity. The approach will build upon existing technology commercializ
and optical fibers. Output in near-ultraviolet to near-infrared wavelength ranges has been demonstrated. These light sources have high br
ools to automatically detect anomalous behaviors that can be related to undesired intrusion and/or attacks upon computer networks, as we
h magnesium oxide (MgO) tunnel barriers. The phase 1 effort aims to maximize the high-frequency sensitivity of the MgO-MTJ sensor devic
less networks.
s, maintenance, and feeding. In Phase I, Ocean Farm Technologies, Inc. successfully demonstrated the feasibility of pen rotation, which is e
ile developing offshore fish farming systems, OFT has recognized a pressing need for non-polluting, low-cost sources of power for system o
inear translation and the two-dimensional angular defection in pitch and yaw of a 7 mm mirror 18-23 cm away. The design is simple and c
morphological identification is not always possible during early development stages. The project proposed seeks to develop a microfuidic b
asing application where higher spectral resolution is needed. Current VIPA fabrication methods limit efficiency, spectral resolution, filter res
y levels with respect to the height of the -100C level. T he proposed Phase I effort will develop an algorithm for lightning probability based
 nd speed imaging radiometers and low cost single beam ocean wind speed sensors. The Hurricane Imaging Radiometer (HIRad), currently
role of the oceans, coasts, and atmosphere in the global ecosystem to make the best social and economic decisions.¿ Never is this vision
mation about potential hydrologic impacts suitable for inclusion in planning. Available studies, however, are most often academic in nature
sors combined with newly introduced highly miniaturized, low power CO sensors. Sensor modules will also include temperature sensors. T
ontinues to remain mysterious and poorly known. Past specimen containers fail to either have the size or volume needed or lack the robust
nd monolithic pryoelectric detector arrays that fully exploit the benefits of domain engineering and "smart-cut" technologies. SRICO will In
ereby to deter potential traffickers, is the ability to accurately identify contradicted material and ultimately to trace it back to its origin. Alph
m sonar water depth data from a large quantity of mobile marine platforms, then harvesting and processing the data to dynamically mainta
ovel, polymer composite sensor will be small, low power, and low cost. This sensor will be incorporated with closed circuit rebreathers, all
National) regulations require mattresses to be able to pass the mattress fire burn test. Typical barrier fabrics use self extinguishing fibers wi
when the filter must be integrated or inserted within an optical fiber. Translume has developed over the last few years means and expertise
w system that will use RBAC in a web services model as a form of middleware that can be "packaged" accessed, configured, and reused by
n efficiency (PDE) and dark count rate (DCR) with more than two orders of magnitude faster maximum count rate (MCR) than Geiger-mode
and off technique. One such method that fits this description is the use of a staring infrared (IR) sensing device (i.e. imager).
d environmental research. This novel compact QCL instrument will have extensive commercial applications in areas such as air pollution an
ases. The proposed technology will save millions of dollars per year in industrial maintenance costs, permit much wider deployment of IR im
after acute exposure to nanotubes. The data will be analyzed to determine what, if any, pathways are affected in the fathead minnow. This
and effluent treatment system for small dairy farms. This would be one of the first digesters built on a dairy farm with a herd size of 50-100
primary molecular recognition element. The developed sensor chemistries will result in a detectable signal in 20 minutes or less and will re
o the U.S. Environmental Protection Agency (EPA). Phase II will establish our credentials for delivering an increasingly vital necessity: reliabl
embrane suppliers, ethanol engineering design firms and the EPA test sites. This positions CMS well for both Phase II success and subseque
e, and then cleans itself by periodically oxidizing them. While the chemistry and physics of this self-cleaning adsorbent are quite different f
sor is based on the technique of Surface-Enhanced Raman Spectroscopy (SERS); the ability of SERS to detect chemical warfare agents was d
ystem currently under evaluation by a possible partner. Eltron also has developed a background patent position in electrolytic water treatm
tment technology for NOx abatement. The technology also will be applicable to exhausts from lean burn gasoline engines, natural gas-fired
onders, and other handlers of hazardous materials.
identify and monitor sources of pollution and protect water quality. Microarrays may be particularly well suited to identifying environment
nomic growth, national energy security, and environmental goals. In the 2007 State of the Union address, President Bush called for 35 billio
velopment of the chromatographic approach as a more accurate commercial analyzer to measure NO2 in the atmosphere. As an added ben
commercial use. The proposed handheld and inexpensive ($100 to manufacture in quantities greater than 10,000 units) electrochemical Cl
anner where no additional reagents or labeled molecules are required. The assays can be performed using inexpensive, disposable fow cel
ic design. If demonstrated at full scale and technically successful, the SP electrode could become standard equipment in electrostatic preci
studies demonstrating the performance of the technology, including catalyst activity and selectivity: and economic analyses and life cycle
ial. The G-sand will be sized and stored to keep the material dry: shingle manufacturer specifications require granules to not exceed 1% mo
nt upon the economics and hence can be challenging to implement. An example is the recovery of low quality heat as water condensate fro
m tetrachloride (TiCl4). Separate operations are required to produce the toxic and very corrosive TiCl4, which must be stored and transporte
r small communities in Puerto Rico. The modular design of the reactor technology will allow us to scale it to medium and large water disin
n per year and has the potential to grow significantly over the next 5 years if a cleaner technology can be realized. Additionally, a clean syng
line materials.
e LED Phosphor market associated with HB white LEDs was $180 million in 2006 and should reach $2.3 billion by 2015. NN-Labs predicts re
cling industry and has received considerable interest in the development of a sorting system for sorting brominated plastics in e-waste plas
percent, and reduces fuel consumption between 8 and 10 percent at low to medium loads. The potential application of the MVCO fuel inje
ation of the product is the ability to use much less expensive feedstock. The United States produced 250 million gallons of biodiesel in 2006
ment of Defense, first responders, state emergency response agencies, and approved foreign countries. In, addition, because of the inheren
ms (GPSS) in the building products industry that effectively improve human health and the environment (e.g., improve sustainability). Know
ity usability. While not measured in situ, burnboxes are thought to operate at temperatures between 600°F and 1200°F. Conventional in
m tetrachloride (TiCl4). Separate operations are required to produce the toxic and very corrosive TiCl4, which must be stored and transporte
 after acute exposure to nanotubes. The data will be analyzed to determine what, if any, pathways are affected in the fathead minnow. This
anner where no additional reagents or labeled molecules are required. The assays can be performed using inexpensive, disposable fow cel
ms (GPSS) in the building products industry that effectively improve human health and the environment (e.g., improve sustainability). Know
ystem currently under evaluation by a possible partner. Eltron also has developed a background patent position in electrolytic water treatm
primary molecular recognition element. The developed sensor chemistries will result in a detectable signal in 20 minutes or less and will re
o better identify and monitor sources of pollution and protect water quality.” Microarrays may be particularly well suited to identify
e, and then cleans itself by periodically oxidizing them. While the chemistry and physics of this self-cleaning adsorbent are quite different f
ic design. If demonstrated at full scale and technically successful, the SP electrode could become standard equipment in electrostatic preci
n per year and has the potential to grow significantly over the next 5 years if a cleaner technology can be realized. Additionally, a clean syng
ases. The proposed technology will save millions of dollars per year in industrial maintenance costs, permit much wider deployment of IR im
d environmental research. This novel compact QCL instrument will have extensive commercial applications in areas such as air pollution an
tment technology for NOx abatement. The technology also will be applicable to exhausts from lean burn gasoline engines, natural gas-fired
nomic growth, national energy security, and environmental goals. In the 2007 State of the Union address, President Bush called for 35 billio
ation of the product is the ability to use much less expensive feedstock. The United States produced 250 million gallons of biodiesel in 2006
cling industry and has received considerable interest in the development of a sorting system for sorting brominated plastics in e-waste plas
ity usability. While not measured in situ, burnboxes are thought to operate at temperatures between 600°F and 1200°F. Conventional incin
o the U.S. Environmental Protection Agency (EPA). Phase II will establish our credentials for delivering an increasingly vital necessity: reliabl
r small communities in Puerto Rico. The modular design of the reactor technology will allow us to scale it to medium and large water disin
sor is based on the technique of Surface-Enhanced Raman Spectroscopy (SERS); the ability of SERS to detect chemical warfare agents was d
onders, and other handlers of hazardous materials.
partment of Defense, first responders, state emergency response agencies, and approved foreign countries. In, addition, because of the inh
line materials.
e LED Phosphor market associated with HB white LEDs was $180 million in 2006 and should reach $2.3 billion by 2015. NN-Labs predicts r
ial. The G-sand will be sized and stored to keep the material dry: shingle manufacturer specifications require granules to not exceed 1% mo
embrane suppliers, ethanol engineering design firms and the EPA test sites. This positions CMS well for both Phase II success and subseque
studies demonstrating the performance of the technology, including catalyst activity and selectivity: and economic analyses and life cycle
commercial use. The proposed handheld and inexpensive ($100 to manufacture in quantities greater than 10,000 units) electrochemical Cl
nt upon the economics and hence can be challenging to implement. An example is the recovery of low quality heat as water condensate fro
unted in aircraft wiring connector. Their purpose is to provide real time situation awareness for component and system health monitoring.
detection focusing on multi-sensor vibration data. Processing modes include signal processing, factor analysis, source separation, feature e
nstrumentation Circuit (EPIC). The army has funded the EPIC for embedded diagnostics, prognostics and intelligent control of electrical sys
in aircraft frames. Fiber ribbons used in computer cards suffer significant breakage failures, usually close to the connectors and at points w
ormance issues such as hydrolysis and inadequate abrasion resistance. Engineers at V-22 primes have said one issue with kapton composit
nt optics detection technology can be extended to the LADS detection mission, but often suffer from several operational challenges. Areté
ging sensor system is used to precisely measure airframe attitude relative to the velocity vector, eliminating the time dependent heading an
sing with trapped ions, and atomic spectroscopy is impeded by the lack of commercially available laser sources that meet the required spe
ta for the purpose of assisting helicopter landing during brownout. Our algorithms will discriminate ground from non-ground objects; rem
ally recognizing and classifying marine targets viewed in submarine imaging systems.
nt aided navigation in brownout or whiteout conditions that can occur during landing or maneuvering in sandy, dusty, snowy or marine env
recommends the use of correlation processing against a reference sensor outside the search area for noise mitigation, and an air-deployed
presently deployed in Iraq and Afghanistan today. This unfortunate reality has spurred both industry and the DoD to press for immediate
ulting in an increase in the variety and complexity of mission scenarios for these vehicles. The successful proliferation of UAV assets into m
ermal detection of disturbed soils associated with IED burial offers a robust signature, but the signature strength in the presence of natura
o expensive and heavy to meet increasing missile loadout requirements. The reduced weight and lower cost of Strapdown Semi-Active Lase
m single points of failure, inefficient performance or failure in dynamic situations and have little to no run-time decision making ability conc
major technical challenge that may be best served by advances in ladar technology. Next-generation intelligence, surveillance and reconnais
ol providing a capability for performance evaluation of direct detection LADAR systems operating in a battlefield environment. The Phase I
 ds effective non-acoustic detection capability deployed from maritime patrol aircraft. Air-dropped buoys exploiting submarine ELF emmissio
s. Present Navy programs are addressing long- and medium-term solutions for acquiring these products, but these solutions require mode
means in the surfzones of forward areas. It will measure, record and report IOPs that are vital to naval MCM operations. The sensor system
MaQS) and develop the Electric Magnetic Matched Field Tracker (EMMFT) as two complementary aspects of a next-generation magnetic a
d method of sonar depth sounding from survey ships, though accurate, is slow to perform. Thus, we propose a new and innovative approa
ndheld applications. The mobile version of the dictionary provides mobilityand independence that leads to opportunity-based learning in c
e interactions with a local populace with different culture and language. This simulation will immerse Soldiers, live role-players, and compu
this project, Vcom3D developed and tested a prototype Mobile LanguageReference for students in the middle grades that included Americ
esexpected
of a novel
to university laboratory
greatly improve solid-state
the clinical method
utility of synthesizing
and data metal
quality of VEMP oxide As
testing. andsuch,
metal
thenanoparticles
proposed workby mixing common
will greatly chemical
impact public hstar

ution of the computational process and the resulting output data. Kitware proposes a co-processing analysis and visualization framework t
an indispensable component for capturing all relevant effects from the huge amount of simulation data. Yet, most visualization tools are lim
The Intergovernmental Panel on Climate Change warns of many possible consequences, including increased risk of infectious disease epide
th¿s greenhouse effect. Robust instrumentation that can measure these gases with both high accuracy and precision and with sufficient s
erials used in turbine engines. The proposed strain measurement capability is provided by a variant of electronic speckle pattern interferom
py (CARS) for non-intrusive measurements of gas species and temperature in high enthalpy gas fows that are currently inaccessible or impr
osis of remaining fatigue life. Previous work in the fatigue literature and at MetroLaser has shown that surface roughness can be a key indic
structures based on integration of a new high speed laser Doppler imaging vibrometer with an automated software data processing suite.
er systems. Since the conventional target-in-the-loop (TIL) adaptive optic concept is generally not effective in many operational environmen
s and spatial light modulators as dynamic programmable masks. Schlieren methods are widely used to visualize turbulence and shock phen
ostic that does not require seeding, works in high or low temperature fows, and can be used over a broad range of velocities. Hydroxyl tagg
tical inspection suite to aid in the manufacture, assembly, and inspection of freeform optical components that are not easily inspected with
systems. Since the conventional target-in-the-loop (TIL) concept is generally not effective in such operational environments, new solutions
extreme environments such as encountered in a gas turbine. The proposed sensor is wireless and provides more information than merely
es in aeroballistic test ranges. The scanner uses a digital streak camera to track an object moving through a pair of laser sheets projected b
ket sleds and their test articles. Streak images will be recorded by using a Galvo motor to rotate a relay mirror that sweeps an image of the
space composite structures. The instrument architecture is based on integration of a new 2D Matrix Laser Vibrometer (MLV) with an autom
ents
ts and optics
of data that are
produced. not easilythis
If successful, inspected
projectwith conventional
will greatly benefitinterferometry. Modern
the biotechnology optical design
companies focusedand
on manufacturing procedures
the use of 3D structures of have
prot

ology. We plan to use open source TTS systems because they often provide fexibility and interoperability, which is essential for research ori
r’s words sound like they are the target speaker’s. In Phase I, we have studied various algorithms for voice transformation. The project has
and can
ening be acoustically
emergency causedcovert, the stimuli
by invasive cannot staphylococcal
and systemic be overlooked,infections
and they can
withalleviate sensory
the eventual bottlenecks.
goal of FDA filingImplementing an effective
of an IND application. Theta
at would make the enzyme stable to clear infections in blood and tissue of the patients.
Because of the sheer amount of data available, building dynamic, complex social networks to represent terrorist activities can be very diffic
nd tracking become exceptionally difficult. First, the high volume of background traffic makes it difficult to maintain tracks within the clutte
m successfully demonstrated in Phase I to globally task sensors to meet system tracking and discrimination needs; (2) is tailored to work wit
e not currently supported in the Ballistic Missile Defense System (BMDS). Employing ground-breaking techniques developed under Phase I o
e infrastructure that provides physical scientists a "plug-and-play" architecture in which they can insert their "physics kernels" and exploit v
o exploiting advanced offensive capabilities. To develop an effective SIAP, the tracking and fusion algorithms must overcome real-world cha
MD requirements for the ASoSC2. The model-of-models approach closely parallels the system-of-systems approach pursued by the Army f
o make quick and efficient determinations of the state of the world through the rules of deduction. This type of reasoning, however, does n
even the most advanced algorithms are still considered developmental. One reason for the absence of global engagement management al
port the missions through the formation of ad-hoc joint Intelligence, Surveillance and Reconnaissance (ISR) teams from assets that are on s
pport standards based instruction, the need to raise student achievement scores through effective teaching, the need for instruction mana
stems to the warfighter while maintaining or decreasing maintenance costs. Each military service has responded to this challenge by under
lting in failures requiring unplanned parts, materials and sustainment procedures. Such U.S. Air Force weapon systems are collectively den
ystem which can be used by teachers and evaluators to create independently accessible, self-paced tests and evaluations for students and
output functionality for individuals with intellectual disabilities with speech impairments
interface design used for accessing electronic media resources on a standard desktop and/or portable palmtop computer
ram, specifically designed to deliver personalized content from the Internet to individuals with intellectual disabilities thereby fostering sel
fficient numbers of qualified science teachers in the middle schools, where interest in science must be kindled. Technology enhanced learn
nsumer product called a Bluetooth wristwatch, a wireless, wrist worn computer interface and display
aperture imaging camera with a convenient visible light camera.
. The preliminary work, though, has also shown areas where design improvements are needed. The proposal objectives are aimed at resolv
phosphorous leaching via the increased fow velocities resulting from the baffles movement under hydraulic head pressure and as a result

earning for children

lly designated and adolescents
red snapper with developmental
species, Lutjanus campechanus, delays
with lesser-valued, related snapper species. Due to the immense popularity and
ests are laborious, costly and not well-suited for the testing market of food commodities. Therefore, we propose to develop a streamlined,
products with the limited harvest capacity of our nations oceans. However, water reuse in recirculating aquaculture systems (RAS) is limited
ystems allow year-around production of aquatic organisms under controlled conditions, require very little water and land, have minimal effl

on and individual refection. In 2004, 28 percent of all K-12 public institutions were involved in some type of service-learning, affecting app
network models of community issues and institutions in order to increase cognitive skills and learn content related to science the environm

ation, and increased foreign competition. In order to compete, catfish producers must become more efficient. Research has shown that pro
e colonies used for pollination. We propose research leading to the design of a hand-held device that could scan a honey bee colony, and q
p new technology for early detection that takes advantage of the fact that small amounts of spoilage cause significant increases in CO2 con
an sense it. Phase II is required to complete the R and D of the sensor hardware, software, and method for delivering the data. Phase II will
ts and enormous economic losses globally. Several groups, including infants, children, young women, the elderly, and those with chronic d

ulty boarding boats, such as people with mobility impairments, balance issues, or lower extremity injuries

dynamic assessment in language arts and mathematics for children in pre-kindergarten through second grade. The goal of this project is to
arsh thermal and chemical environments and in-line systems remove water in real time. Phase I was very successful both technically and co
Rd program
tests to demonstrate a fieldcommercialization.
and downstream system with costs less than $1,000 and payback times less than one year. Previous results in combination wit
oducts. This will provide value for low cost high quality foods. This will enhance populations potential for low cost quality food alternatives

yalmonella
recognizes
inspecific sounds in the environment on a pocket-sized device; and(2) alerts the user on their mobile device via vibration, image
1-2 hours.
od, drinking water, recreational water, reclaimed water, and to potential bioterrorism agents.
w vision musicians to accomplish typical tasks important to performers and composers with normal vision

ethods do not always provide reliable results. Their accuracy typically depends on the datasets these methods are derived from or the assu
tsrenewed national
for heating priorities
buildings. to develop
The problem replacements
can be mitigatedfor
by petroleum-based fuels that
using biomass materials thatare non-polluting
exist, and renewable.
and are currently Microbe-based
underutilized, pro
on farms. This
n farms for heating buildings. It will result in the development of a commercial machine for cost-effective production, and a commercial sto

audio through two different versions wired (Phase I) and wireless (Phase II)
he organism leading to Necrotizing HepatoPancreatitis (NHP) is frequently encountered in North, Central and South America and can lead to

U.S. nearly $600 million annually and with a national eradication effort being proposed, the need for a second generation vaccine tool that

ne to the Hybrid line, and the best strategy to ensure continued improvement in growth, pond survival, and TSV resistance. Two alternative
en free (SPF) and specific pathogen resistant (SPR) shrimp broodstock and disease-free clam seed.
ts (e.g., traumatic brain injury, stroke, brain tumor) and their caregivers to sustain therapuetic support through assistive technology withou
pable
softwareof being launched
and planning on publicly
services accessible,
and tests updated
them with threecomputers
distinct market segments among Maines adult population, (2) develop a thoroug
nsitioning), private companies (elder benefits packages), financial service industry (client relations and retention), as well as direct sales to

These
for emissions
hydrolysis andare environmental
fermentation concerns
of mixed as a result
feedstocks; of their
assess impact
markets; on odor
assess cost and general
benefits air quality.
to Buhl Volatilesand
infrastructure; emission monitoring
estimate economicof fea
CA
osts for feedstock and energy and reduced capital cost from eliminating mash cooking will enable ethanol production at a scale that fits loc

fficulty for high school chemistry students. The classic ball-and-stick model, developed in 1865, is still used today to convey the fundamen
ement chemistry classes for real time communication between the hand held physical model and the virtual software model to enable use

gnal via a wireless link, eliminating many of the wires and connectors associated with arm prostheses, and allowing connection to modern
mputer-assisted motion
tes of application, training
and the can stimulate
economics the growthtea
of vermicomposts of production
neural connections
and use in the greenhouse and field.
ider range of plant pathogens, parasitic nematodes and arthropod pests an assessment of the shelf-life of vermicompost teas, identificatio
buried communications (telephony, CATV) and power lines. The objective of the project is to provide improved, cost-effective hardware and

ratory wind tunnel and field saltation data to that of existingvertically oriented sensors.The wind erosion sensor provides high resolution da
cost-effectiveness of locally produced fresh vegetables and other crops in greenhouses. Plant growth requires light but, in many regions of

), and the USDAs Forest Services Northern Research Station to investigate the suitability of PSCs recent innovation, Plant Root Characteriza
Northern Research Station, (NRS), has a long research history into tree root dynamics and has evaluated and used most state-of-the-art app

irtual physics lab experience for college level and/or advanced placement high school physics classes. Each online lab will be comprehensi

lish sentences
eatedly througout the range of motion to reduce spasticity/contracture and increase functional performance
ecombination in plants. We will produce a specialized vector that carries the desired mutant locus, then use controlled DNA replication to p

tion was simulated in order to demonstrate feasibility and to quantify the reduction in station dwell time compared to other railcar loading
s to be selectively detected in crop enclosures containing both the unique volatiles and potential identified interferants. Our second objecti
ely determining concentrations of unique mold related volatiles as low as 1 ppb in the presence of other typical crop related volatiles.
ow the meanings of the 4,000 most frequently used English words when they hear them and see them in print and can pronounce them. T
know the meanings of the 4000 most frequently used English words when they hear them and see them in print and can pronounce them.

The costs of producing in vivo however, are high relative to in vitro approaches due to the expense of insect hosts and labor. In response, w
matode production costs will decrease and product utility will be expanded in various crops. Once proven successful, the system can be ada
on practical for a variety of applications in education, including: preservice education, induction, supervision, inservice education, educatio
n practical for a variety of applications in education including preservice education induction supervision inservice education educational re
dingly, the Companys approach diminishes the risk of non-target impact and of cumulative environmental harm occasioned by usage of oth
and in other markets.

to participate in simulations tied to core National Science Education Standards. TILE is for use as a supplement to K 12 science curricula for

orption marketplace is dominated by loose granular clay materials, e.g., the kitty litter type products, that are sold in large volumes. The com
sight cell phone service to improve independence
gestion. This patent pending system differs in three ways form other anaerobic systems now being tried: First the substrate to control PH in
here synthetic manure was used; to using agricultural waste products that have little or no value. This innovative process would utilize a ne
ons computer.Current
aquaculture. The "smart barrels"
vaccination will incorporate
strategies magnetic sensors,
for the prevention an LED display
of aquaculture diseasesand wireless
utilize communications
traditional resulting
technologies in achemical
including unit thatoc
sessed. To determine whether this is feasible, BG will be created from a known important aquaculture pathogen, Flavobacterium psychrop

e losses (non-ambulatory and dead animals) are associated with the rapid accumulation of lactic acid in blood and the development of me

e field. Our source offers a 20ns neutron pulse with a repetition rate up to 1kHz. The goal is to develop a source with 1000hrs of continuous
Effective code breaking attack methods have been developed for attacking many of the cryptosystems used by criminals, however, frequen
of biometrics for screening processes in the Phase II of this proposed work. This system will have a range in excess of 100 meters, if neede
ed plasma neutron generator will be pulsed to produce the activating neutrons whose pulse length is 100 microseconds with a fall time of l
ble to allow the advantage of time and space to identify and intercept threats before they can get close enough to affect the Homeland. Th
o spread/cut/rip automobiles or other metal constructions apart in order to save persons who may be trapped inside. The Jaws of Life wer
esult in construction of a Radiological Dispersal Device or Dirty Bomb. A pervasive means of securing radiological materials and identifying b
ties of individuals at the scene of an incident. Such tools are preferably not dependant on local infrastructure, which may be compromised,
of energetic materials which will involve collection and subsequent concentration of particles, and real-time coupling to a hand-held ion m
to protecttechniques
practice itself. AFCOtoSystems
capture Development
and integrate (ASD) proposes
multimodal to advance
biometrics the state
for various of system
identity security
screening monitoringThese
applications. technology and business
collective meet its or
our planned
mple collectionPhase III private
system. Used infunding and commercial
conjunction with any ofoffering success. trace explosive detection technologies, this will create a viable real
the commercial
tion technologies, it has broad commercial opportunity. Depending on the detection technology used, this would be applicable to inspectio
her fully legal and sanctioned industries is paramount to interrupt the terrorism value chain. This value chain relies on stealing radioactive s
tuational awareness of the first responders can be quickly and easily overwhelmed. At emergency scenes, with the overburdened first resp
on of the spread of radioactive materials and nuclear weapons has reached a state of heightened urgency in recent years, especially since t
es with time. Illicit nuclear materials represent a threat for the safety of the American citizens and the detection and interdiction of a nucle
ting the spread of nuclear weapons has reached a state of heightened urgency in recent years, especially since the events on September 11
ecial nuclear materials (SNM). Preferred neutron sources for the detection of SNM should have narrow pulse width, low source neutron ene
er sources used in ion detection instruments, cost effectively and without performance offsets. In Phase I, ANI worked with development p
or a technological capability for getting mission critical and time-sensitive information to people who need it in a secure and timely fashion
notubes (SWNTs). The proposed materials will be utilized in chemiresistor microarrays for improved detection of small molecule gases with
Microwave Vehicle Stopper. Our system transmits modulated microwave energy to the target vehicle that is tailored to disrupt the compu
he computational speed of field-programmable gate arrays (FPGAs). The proposed system, which is partially hardware-based, will provide d
f the type of attack will determine the type of emergency personnel and response needed. The location will determine by proximity which
e Device (SINBAD). SINBAD will leverage capabilities and leverage lessons from guard technology to yield an enhanced boundary control an
d prevention capability. The iBEAR is built on the success of our phase I research of botnet collection. Collection of malware is done throug
and easily deployable. None of the current mechanical vehicle stopping technologies meet the requirements for small, portable highly effe

nvironment for the existing Project Safe-Cracker project, which will allow a massively parallel effort to decrypt files intercepted by Departm
s such systems to achieve 1 to 2 inches greater penetration for dense cargo (steel or equivalent) while, on average, producing the same am
olid-state, thermal neutron detectors for use in radiological inspection. This will be done by testing a novel, high-density, energetic ion depo
p and demonstrate a truly integrated wireless physiological sensor suite and associated health monitoring software system capable of asse
btained. While vapor sampling is limited by the available vapor pressure of the target substance, particles are limited only by the three step
al chemical analysis. The proposed peak detection technique is based on Continuous Wavelet Transform (CWT). Its distinction from other p
e remote sensing of the improvison explosive device (IED) in the battle field, biological and chemical agent dection in countering terrorism,
y interconnected and mutually dependent systems. With recent technological advances in wireless mesh networking technology, seamless
eed immediate notification of the problem to provide quick assistance to passengers and prevent additional collisions. One solution is to pla
nt systems, and global war on terror (GWOT) applications.
to protect itself. AFCO Systems Development (ASD) proposes to advance the state of system security monitoring technology and meet its o
n, as well as its ability to reconstitute itself after and during attacks. The successful completion of the work proposed here will provide a hig
 ters. By providing detailed information over and above a simple count of traffic, the organizations responsible for road and portal managem
has direct sunlight, loud sounds, and vibration.
ets, without causing permanent injury or lingering aftereffects. Current electric stun technology is either hand-held or short-range and teth
to large numbers of people and create anxiety for many more. The detection and mitigation of attacks on transportation are made more d
a target in a defined area. Turret-mounted forward-looking infrared (FLIR) imagers have a high POD for targets within a narrow field of view
quo; (pee-ay’-zer) – an untethered electro-muscular disruption non-lethal stun weapon based on piezoelectric technology fo
t intelligence contextual knowledge and integrates with Security Event Management platforms, and transition this technology to commerci
ors in both silicon and silicon carbide. These detectors will provide detectors with neutron conversion efficiency exceeding 40%, depending
ective chemical vapor detection systems. Much of the work to date has focused on, and is applicable only to, individual technologies. As ne
ls is therefore critically important for homeland security. Despite this threat, there exists no commercially available, portable gas detection
10B/Gd loaded neutron-sensitive microchannel plates with high performance scintillators and readout to provide both neutron and gamm
emiresistor Sensing Arrays for Detection of Small Molecules Gases. The proposed work focuses on demonstration of the feasibility of devel

the system to have an open interface so that new and existing sensors and devices can easily be designed to use the network. Our goal is to
rates are essential for use in rapid Nuclear Resonance Fluorescence and EZ-3DTM imaging technologies. While isotopic identification of sh
ecurity, the DNDO is seeking replacements for devices that commonly incorporate such material. Physical Optics Corporation (POC) propos
orporation (POC) proposes to develop a new Versatile Trace Explosives Sampling and CollecTion (V-TEST) system. This noncontact system wi
lletized goods is a universal procedure, POCs novel secure wrap can be applied worldwide. Additionally, as this plastic sheeting is also used
e-bomber threats, Physical Optics Corporation (POC) proposes to develop a new Explosive Substance Detection Spectroscopic Standoff Sys
er, Physical Optics Corporation (POC) proposes to develop a new automated High Probability Weatherproof Remote Search and Rescue See
can be marketed to customers currently utilizing nuclear source gauges. While nuclear gauges are an established technology, their radiolog
iac status of the firefighter. Alerts are generated according to the level of cardiac strain for a firefighter or the presence of dangerous arrhyt
nsitive detection of low molecular weight toxic industrial compounds (TICs) and other compounds of interest. These sensitive materials wil
. Consequently, the Department of Homeland Security requires a network of sensor technologies to defend against this threat. As part of th
biometric reliability measures and fusion. While multiple papers develop quality-based measures and fusion techniques, there has been n
re, and wireless communication with a base station for reporting in order to strengthen the nation s ability to monitor and safely utilize rad
em. Our Team will
ue architecture thatdevelop and integrate
will enable state-of-the-art
sensor modules research
for a variety in ontology,
of operating data fusion,
environment. Thedata mining,
neutron and data
detectors arewarehousing
based aroundinto DMnet
nanoporou
nts than conventional detectors. These features will enable hand held neutron detectors for customs inspection and other fissile-material d
elligent electronic devices, which can be incorporated into existing systems without interfering with control functions and disturbing their r
standard of choice for machinery control, building monitoring, and a host of other industrial, commercial, and government control system
edical orphaned nuclear devices. One such device is the Nuclear Density Gauge (NDG), which is used as a portable test instrument on cons
s with limited data processing and communication capability, because of reliance on Personal Digital Assistant technologies. PDA based arc
rusion into cargo at the unit (box) or pallet level in the event of tampering, fraud, or damage. The detection system integrates wireless com
ble for other deployments, including embed in cell phones for a widely dispersed distributed detection network, or in planned devices such
onfigurable, smart, based on extension/enhancement of LEAP low-energy modular embedded-sensor-architecture developed at UCLA. A ro
on about aof
e purpose specific first zonal-based
providing responder from a fexible
radiation array of We
monitoring. multiple sensors
will also to aalgorithms
identify receiver. Our
thatsolution combines
minimize short-range,
the number low-bandwidth
of sensors required to
ental or deliberate nuclear contaminations. This creates a number of attractive commercial opportunities for our proposed system. ZonTrak
d highly sensitive eye-safe laser-based standoff sensor technology for detecting films and residues of explosive materials. This sensor detect
se with irregular loads. IST is proposing to develop a stretch wrap material that provides a visible means of tamper indication. This will be a
rt valve prosthesis that will be ready for clinical evaluation. Existing replacement valves suffer from several shortcomings. Specifically, biolo
ness, recreation and other community based health interventions for a segment of the American population that is currently dependent up

for imaging lungs as well as other soft tissue in live laboratory animals based on permanent magnets that are reasonably priced and easy to
of prevalence in the long-term and extended care environments cluster around 8% and appear stable over the past decade. An estimated 3

ading biological research, providing diagnostic and prognostic value to physicians and facilitating target discovery during drug and vaccine d
cally designed backrest support for ultralight weight wheelchairs that will provide necessary postural support and provide a variety of positi
d subsequent calculation of various properties, often related to their biological activity, have become extremely important for drug discove
esources for the study of aging. The basic longitudinal survey instrument has been supplemented with data from a variety of other sources
arrays allowing for real-time ultrasound volumetric imaging. To date, the commercial development of 2D transducer arrays having thousan
ss of vision in the adult population. AMD can be classified into the "dry" form and the "wet" form. The dry form involves apoptotic changes
dustrial compounds, pollutants, and chemicals, but predicting the relative risk of this exposure, especially over time, is challenging (US CDC
supplement nervous system function that was lost during disease or injury. Particular success has been realized in the cochlear prostheses
o expand the capabilities of the Medicare Research Information Center (MedRIC) recently established by Acumen LLC with earlier support
o expand the capabilities of the Medicare Research Information Center (MedRIC) recently established by Acumen LLC with earlier support
wide application ranging from studies of carbohydrate-protein interactions, in vivo cell imaging, biolabeling, cancer diagnostics, and to vac
rbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles of carbohydrates in biological process

aving upper limb deficiencies have proven inadequate for some activities, most notably play. The critical component in these systems that c
potential for the treatment of addictive disorders, including cocaine addiction. This proposal is a phase I STTR to investigate proprietary no
novel device to dissociate tissue from donor pancreas using ultrasound for the recovery of pancreatic islet cells for transplantation, and 2)
t C. perfringens epsilon-toxin action using a novel approach for the inactivation of pore-forming toxins developed at Innovative Biologics, In
neurological and psychiatric disorders and can have a significant impact on quality of life, treatment efficacy, rehabilitation and ability to fu
affecting over 18 million Americans, is responsible for more mortality and morbidity than any other sleep disorder. Dentists are increasingl
ortality and causes delays in patient care during and immediately after dialysis. It remains one of the most vexing problems associated with
s from infants and then sending them to a lab for analysis. There is an increasing necessity to screen for a number of disease conditions for
ory approvals program on a set of next-generation sleep disorder monitoring sensors. Advanced Medical Electronics (AME) completed in Ju
ntrast to acute care is significant: a physician can often address acute problems with prescriptions and/or procedures, but this is often not t
ature portable electroencephalograph (EEG) recorder that can be easily used in the home to collect data for longitudinal surveys of the eld
for pulmonologists and respiratory therapists specifically designed for the care of home ventilator-dependant pediatric patients. Following
ography to identify the clinical effects of spinal unloading in patients with radicular symptoms. Unloading therapy will be performed in pati
arable system to assess adherence to study protocols in complementary and alternative medicine (CAM) mind-body interventions. The pro
ode wireless surface electro-myography (EMG) system, including a custom integrated circuit (IC), for research and clinical applications. The
way-finding device utilizing the unique magnetic anomaly patterns that exist in modern, man-made structures. The proposed system will r
le the creation of an ambulatory electroencephalograph (EEG) instrument that can transmit 160 full-bandwidth (DC to 7.5 kHz) channels o
lity in women. Major shortcomings with current treatment are the high level of side effects and insufficient efficacy, particularly for patient
nd activation of signal transduction proteins in breast tumors. The goal is to create new "companion" diagnostics to better select patients lik
iagnosed
images each
and year in the
to perform USA,
time yet only
averaged 20%-25% of
sub-second 3Dthose patients
perfusion mapswill be diagnosed
which at adifferent
differentiate sufficiently early stage
vascular to be The
territories. cured by surgical
resulting or
quanti
perfusion abnormalities in stroke and cerebrovascular disease.

s.s Current methodswith

to be addressed for manufacturing theseand
new more effective vectors use either
less toxic the 293
therapies. Thecell
mainline or the PER.C6
objective of this cell
SBIRline. These
project producer
is to developcells
a newprovide comple
therapeutic
Atak(tm), a product aimed at improving t
d in months rather than years. It is a disease with great need of novel therapeutic approaches. Within cancer gene therapy the use of ade
nique for the diagnosis and monitoring of asthma, cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The presence of e
0 million Americans suffering from asthma with an annual societal cost of over $18 billion. Sadly, about 5000 Americans die every year from
ctims live in endemic, tropical countries. Aggressive mosquito eradication programs in the 1940s essentially ended the incidence of locally-
n. Currently available drugs include opioids, anti-epileptics, topicals such as lidocaine, NMDA antagonists, and tricyclic antidepressants, no
t cuts across all age groups: daily sleep loss. Cumulative sleep loss induces excessive daytime sleepiness and impairs cognitive performance
isease and other dementias. Millions more suffer acute cognitive impairment from sleep deprivation, stress, circadian disturbances, and ps
engineered cells into damaged tissue, where ideally they will engraft and remodel the damaged tissue into healthy tissue. However, numer
g cause of implant failure in a number of fields including oral, craniomaxillofacial (CMF), orthopedic, and cardiovascular surgery. These infe
of adults over 70 years have at least moderate periodontitis and over a quarter have lost their teeth, which has serious repercussion on hea
the United States (Boden, 2002). Autologous iliac crest bone graft continues to be the gold standard because it provides the three essentia
ity of an innovative, new device for advanced locomotion analysis including: ambulation assessment and fall prevention, postural perturba
 stage that a demonstration of its clinical efficacy in sepsis would put the generation of a product to treat sepsis on a relatively eas

in biological processes are becoming better understood, but this new frontier has only begun to be explored. Tissue regeneration is also a
in biological processes are becoming better understood, but this new frontier has only begun to be explored. Tissue regeneration is also a
ming development with potentially devastating consequences at individual, societal and economic levels. Surprisingly, this student apathy i
ng correlation to the incidence of various common human diseases. However, a critical shortcoming in quantitative studies of the correlatio
-speech (TTS) synthesis system known as ModelTalker and software called InvTool which guides individuals in creating personal synthetic v

eloping safe and effective therapeutics for the management of pain and addiction. Opioid drugs are the standard of care in the treatment o
ntegrated, transparent technology solutions that address bottlenecks in information integration and business process management. Our vi
expanders that have delayed expansion with the capacity to be reshaped by the surgeon. Currently, plastic surgery routinely uses silicone b
roperty into the commercial marketplace, and develop a protein array for clinical surveillance and diagnosis of common respiratory infectio
es that belong to the family Orthomyxoviridae, causing approximately 114,000 hospitalizations and 20,000 deaths annually. Several drugs a
organotypic brain slices and dissociated cortical cultures, have great potential to contribute to the understanding of basic CNS processes, d
mmary/Abstract: The multi-well or microwell plate has become ubiquitous in research and clinical laboratories for processing multiple samp
) each year. In the US, the cost associated with the treatment, hospitalization and rehabilitation of TBI are estimated to be $48.3 billion ann
abled the growth of powerful research techniques such as time-resolved X-ray diffraction studies for understanding dynamic biological phe
well as portable, there has been growing utilization of neutrons in a similar manner. Contrary to X- and ?-rays, the probability of interaction
ed as important research areas in cancer imaging. Goal of cancer diagnosis and prognosis research is to develop new imaging techniques to
micals posing the greatest threat to human health. Significant amounts of lead are found in a multitude of consumer goods, ranging from e
g power for 511 keV gamma rays, high light yield of over 20000 photons/MeV, and rapid decay of 32 ns. It achieves high coincidence timing
otential to quantify the rates of biological processes in vivo. The availability of short lived positron-emitting isotopes of carbon, nitrogen, ox
ed as important new tools for cancer research. Of these systems, x-ray microcomputed tomography (microCT) shows promise as a cost-effe
ed tomography (SPECT) and positron emission tomography (PET) are powerful, non-invasive medical imaging techniques that provide an im
on, high-sensitivity, three-dimensional (3D) functional and anatomic images of living systems. Positron Emission Tomography (PET) offers h
ng biological processes taking place on a molecular level. X-ray crystallography has been successful in determining protein structure, howev
f scientific knowledge is vast and that breakthroughs are possible if software can do a better job of connecting researchers with knowledge

ve particle agglutination technology for improving the performance of detection of human immunodeficiency virus (HIV) antibody in body
and quantitative enzyme-linked immunosorbent assays (ELISA) for (1) measuring anti-RhD (anti-D) antibodies in patients at risk for Hemolyti
m, has been hampered by alcohol's promiscuous pharmacological effects and the complex etiology of addiction. People drink in excess for
hat prevent biofilm formation and thrombus. A key feature of this technology is that it will prevent biofilm formation without an associated
ermining if a breast mass is benign or malignant. Mammography is the main imaging procedure (screening) for detecting suspicious finding
rapeutic efficacy of radiolabeled alpha-melanocyte stimulating hormone (a-MSH) peptide analogs that target a-particle emitting radioisoto
ng molecules radiolabeled with lead-212 in treatment for metastatic melanoma and disseminated colon and pancreatic cancers. Another is
ensitive and real-time platform capable of multiplex detection of biomarkers and pathogens using glycan microarrays. Glycans, which are p
and characterizing the human proteome. A promising area where proteomics can have a major impact is autoimmune disease. Proteome-
h 40,000 new cases reported each year. While most of these patients greatly benefit from highly active anti-retroviral therapy (HAART), the
detecting colorectal cancer (CRC), the second leading cause of cancer deaths in the U.S. Such non-invasive testing, if instituted for a large se
fibromatosis type 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene. In children, NF1 causes learning disabili
molecular diagnostics technology based on the detection of microRNA (miRNA) using readily available clinical samples. Molecular diagnos
detection
rter of major
of all polyps aremutations
missed onincolonoscopy
patients with acuteto
leading myeloid
cancerleukemia (AML),
deaths and non-BCR/ABL
the need to performchronic
moremyelogenous leukemia (CML)
frequent colonoscopies. In ourand mye
applica
help speed-up the procedures. This could have major importance for colon cancer prevention efforts in the United States.
ke victims using a novel therapeutic regimen and robotic device called "AMES," an acronym for Assisted Movement with Enhanced Sensati
ntal function and health can hardly be overstated. However, our knowledge of the molecular biophysical basis for how GPCRs bind to their
m Hand Hygiene Prompts (RHHP). RHHP will deliver voice messages at random times on a hospital foor, reminding listeners to perform ha
s an effective treatment for diabetic gastroparesis. The NO will be delivered using Amulet's NORTECH nitric oxide releasing technology. NOR
e. Commonly associated with the alcohol-acetaminophen syndrome, its clinical course is unpredictable and polarizing, with death as the ou
 , as it almost inevitably leads to end-stage renal failure, a life-threatening condition that necessitates renal replacement therapy. Few, if any
lung diseases including pulmonary emphysema, cystic fibrosis, and idiopathic pulmonary fibrosis. However, increasing demand for suitable
pite advances in diagnosis and therapy, these tumors show a high incidence of recurrence, have a poor prognosis and lack effective therap
tein (collagen) is localized in the skin, or excess collagen may be collected in the kidneys, lungs, gastrointestinal tract, and heart. Scleroderm
mmation of the lining, or synovium, of the joints. It can lead to long-term joint damage, resulting in chronic pain, loss of function and disabil
ing persons who die at the scene of the accident, is approximately 11,000 cases per year. The number of patients currently affected by SCI
based content to target upper extremity movement therapy goals and evaluate the clinical efficacy of the CosmoBot Robotics System as a th
that can cure tumors without progressive infection of the host. Previous experiments by others employed anaerobic microorganisms for ca
he world. Existing therapies are suboptimal and the search for alternative therapies is imperative. Recent years have seen a tremendous in
armaceutical products as fusions with a synthetic "anchor" protein in bacteria, and subsequent proteolytic cleavage, will be developed. Th
diagnostic for the early detection of age-related macular degeneration (AMD). It relies on a functional test of dark adaptation kinetics (the t
ent for mild psoriasis. It is based on the recent discovery of a cell signaling module important for the regulation of keratinocyte proliferation
ding cause of cancer death among men in the US. There are currently no approved therapies for hormone-refractory prostate cancer. Epide
public health toll, especially on children. Mounting evidence suggests that these disorders can impact physical and mental development. D
kinase (SK) that are effective as therapeutic agents for retinal and choroidal vascular diseases. Because of its critical role in sphingolipid me
g pancreatic beta cells for destruction and remains a major cause of morbidity and mortality in over 1% of the population worldwide. Altho
Vax-SVN(tm) based on the use of a proprietary costimulatory chimeric ligand, 4-1BBL, designed to specifically deliver survivin, a tumor asso
specific antigens (TSAs) have shown efficacy in preclinical models. However, their therapeutic efficacies have been rather limited in clinica
APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesotheliom
uction protein crystal detection microscope, the Crystal Finder(tm) microscope workstation, incorporating extinction polarization and quan
orld Wide Web based application for training providers of moderate sedation. The creation of a Web based training tool will allow providers
isplay technology that will aid clinicians in diagnosing and treating unexpected events in critical care environments. Unexpected events occ
macodynamic display (PkPd Display) intended for anesthesia care providers. In Phase I, we designed a display that was based on a two drug
mulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (M
ke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet
perfusion injury which occurs in10-20% of lung transplant recipients as the consequence of unavoidable processes of procurement, preserv
ut mosquito activity, phenology and distribution that informs integrated pest management decision making. Vector control programs curre
e environment, and sheepshead minnows (Cyprinodon variegatus) are the most commonly used species in salt water environmental testing
ulties and compromised quality of life for the patients. Lung cancer is one of the major diseases causing airway obstruction. According to t
interaction. The informed consent process requires that patients not only be given information about proposed medical treatment, but th

mmense efforts currently underway to better understand associations between disease phenotype and genotype. These efforts promise to p
derstanding of the molecular, cellular and toxicological properties and mechanisms of a drug candidate. Relevant pieces of information are
ormal composition and physical properties of airway secretions in CF patients. Additionally, the lungs of CF patients are particularly suscepti
of these diseases affect adversely the central nervous system (CNS). The mainstay of treatment is enzyme replacement therapy (ERT). How
Encoded Sortable Particle (ESP) technology. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic fo
andheld attachment mounted on the colonoscope shaft which provides a physician with real-time feedback on the force and torque applie
hat in the western hemisphere, retinal neovascularization resulting from diabetic retinopathy is the most common cause of new blindness i

patients is an important tool in the management of disease. Current methods for monitoring tumor response to therapy using imaging inclu
he University of Iowa is proposed to development a noninvasive nocturnal hypoglycemic alarm. The goal for the alarm system is to provide
ployable or wearable personal sensors for monitoring point-of-contact exposures to airborne chemicals through biosample testing. The bro
ed cellular therapy regimen for treating hypoxic-ischemic (HI) injury and its related outcomes in neonates. Pre- clinical studies performed i
as well as non-surgical procedures. It is the ethical obligation of all research personnel involved with the care and use of laboratory animal

ess suitable for highly multiplexed detection of pathogenic mycobacteria in environmental samples. Specifically, this project aims to develo
 tures that will significantly increase the efficiency and decrease the cost of routine hearing testing. The most-often used earphones employ
ed drastically in recent years. What started as a problem primarily associated with hospital-acquired Enterococcus infections, has not only
certain diseases of the inner ear by developing sustained release formulations for anti-infammatory drugs which can be implanted directly
e to dosing problems with the calcineurin inhibitors by developing sustained release subcutaneous injectable formulations for the drugs ta
neous drug delivery systems in order to achieve a more continuous dopaminergic stimulation in the treatment of Parkinson's Disease (PD).
es, is characterized by infammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins in lung
ly, with more than 4.5 million Americans currently suffering from the disease. Clinical management of AD is complicated by lack of effectiv
y - insufficient beta cell mass (BCM) to meet metabolic demands. Unfortunately, advances in diabetes are slowed by a lack of reliable meth
ury. Injuries to the peripheral nervous system (PNS) are a major source of disability, impairing the ability to move muscles or to feel norma
Abstract Axona, Inc. is a new small-business engaged in the early stages of developing small molecules for the prevention of axonal degene
nant bacille Calmette-Gu rin (rBCG) strain that displays reduced toxicity and improved cancer immunotherapeutic properties. We believe t
on for a traumatic brain injury (TBI). Between 75% and 90% of these are mild or moderate injuries. These can infict profound and persisten
e a new approach for objectively measuring the functional impact of pain, and changes thereto, during the course of a patient's treatment.
rease in perinatal mortality, as well as increased risks associated with in vitro fertilization procedures, the number of preterm (< 37 weeks p
sed instrument
cord for the comprehensive
injury and muscular assessment
weakness. Adaptability of chronic pain
is particularly (i.e., the
important location,
because noquality, intensity,works
single solution distress,
wellinterference, and
for all types of dibeliefs dim
ed with its use, is achieved through a novel method that captures the information processing capacity of the human motor system.
nology platform
amily focks for engineering
of domestic fuorogenic
birds to be monitoredfunctionality into living
in remote locations Bacillusrevolutionize
and would spores. Fluorogenic
the abilityspores (F-spores)
to monitor produced
and control theat BCR ap
spread a
idly comply with OIE (World Organization for Animal Health) standards regarding the identification of AI in commercial poultry operations.
e organization of human and other genomes, for unraveling the etiology of genetic disorders, and for studying medically important pathog
software programs that provide brief interventions for heavy drinking college students: The College Drinker's Check-up (CDCU). The CDCU w
eminate an Internet based (web) application called Overcoming Addictions (OA). OA will be based on the cognitive-behavioral change proto
ioral problems. Culturally specific stress is associated with the risk for these problems. The objective of the proposed research is to develop
plication to support the development of an innovative, online training program to aid in the dissemination of Behavioral Activation, a thera
ication to NIMH to support the development of an innovative, online training program in Panic Control Treatment for Adolescents (PCT-A).
PCRs). Among the most important of these are drugs used to treat neurological disorders, such as pain relievers, antidepressants and anti-
ntense focus on inhibiting the process both for chronic infammatory disorders and for conditions where infammation plays a contributory
human responses to drugs. A key technical hurdle has been the difficulty of incorporating complex tissue architecture and cellular microen
ted source of beta/islet cells for transplantation, however the biologic factors required for this process have been difficult to ascertain part
s and 570,280 cancer deaths in the U. S. in 2005. The National Cancer Institute solicits research proposals to develop cancer treatments via

ften lead to frailty, falls, fractures, immobility and institutionalization. At any age this decline can be ameliorated by progressive resistance t
c laboratory discovery that becomes applicable to the diagnosis, treatment or prevention of a specific disease". Our goal is to improve the p

synthetic organic chemistry. The ability to control the regio-, and stereo-, and chemo selectivity of reduction is of particular importance wh
ger (BFI) which can measure the electric field in human skin non-invasively. The hand-held BFI scans a vibrating sensor over the skin withou
he way toward, MRI-guided breast cancer diagnosis and therapy. This effort will address several pressing needs in MRI-based breast cancer
on pertinent to disease is more clearly evident now than ever before. However, the avalanche of non-integrated data produced by today's t
y, virtually all lung cancer patients are symptomatic at presentation. As a result only 30-35% of patients have sufficiently localized tumors to
se- based Whole Genome Amplification (pWGA) technology invented by Drs. Stanley Tabor and Charles Richardson at Harvard Medical Scho
sample preparation that are faster and easier to use than existing devices. New technology based on proprietary concepts enables ultrafilt
hogens around the world. They are part of a larger group of so-called fastidious pathogens that are difficult to study because, for a wide ra
ult of a blunt trauma causing a partial collapse of the lung. While a pneumothorax is easily treatable, it can become life threatening if not d
rhagic shock is responsible for significant mortality and morbidity in the United States. Available intravenous fuids administered at the incid
idents, and the primary cause of death on the battlefield. Early and effective hemorrhage control can save more lives than any other meas
Studies. The overall objective of this project is to develop the first software tools for exposure reconstruction using space-time datasets. De
to offer tools that are specifically designed for the geostatistical analysis of both aggregated and individual-level health data, providing: des
a new, comprehensive approach for evaluating clustering in case-control data that accounts for residential histories, risk factors, covariates
que miniature ophthalmic intraocular pressure (IOP) sensor, to be retrofitted into the cannula of a conventional Glaucoma Drainage Device
edge of genomic structural aberrations/variations and improved understanding of their association with cancer. The long-term goal of this
r the production of high-purity polyclonal antibodies. Polyclonal antibodies are important reagents used worldwide for antigen detection an
n of Lyme disease especially early disease. Lyme disease is the most common vector borne infectious disease in the United States and Euro
s the most prevalent vector borne infectious disease in the United States and Europe and it continues to grow geographically. The enzootic
than 20 million patients have chronic kidney disease (CKD) and these numbers are increasing annually. As a result, the number of patients
ty of diseases. The development of labels to non-radioactively track therapeutic cells in vivo is needed to measure the efficacy of delivery s
r healthcare providers worldwide. Currently, the gold standard for many manifestations of vascular disease, especially arterial occlusive dis
mune responses via the activation of their cognate receptors expressed on the cell surface. Dysregulation and genetic defects of these cyto
ry reaction of the body due to bacterial infection. The mortality rate of sepsis remains high in intensive care units around the world but the
proposes to prototype a portable, handheld cornea and anterior segment optical coherence tomography (CAS-OCT) scanner for use in clini
or HIV RNA levels ("viral load") has been identified as a major barrier to HIV care worldwide. An inexpensive, rugged and easy-to- use diagn
nthesis of long DNA sequences and for their insertion into bacterial chromosomes with concomitant replacement or deletion of unwanted
y measurements. Linked to DNA response elements they provide a means to screen compounds that alter specific signaling pathways. Effic
ording technology called digital telemetry (DT) for recording wideband neural signals in rats. DT is wireless, allowing the subject to move fr
mentative and Alternative Communication (AAC) devices are often the only channel available by which these individuals can communicate
's disease (CD), are chronic, lifelong, relapsing illnesses, affecting close to 1 million Americans and costing approximately 2 billion dollars/ye
rmine the relative impact of competing treatments for addiction. The goal of this project is to develop software to compute power for met
d review.
ases and conditions such as obesity, cancer, hypertension and stroke, diabetes, asthma and cardiovascular disease. Additionally, African Am
ory tract for the treatment of both respiratory and non-respiratory diseases. These agents include surfactant, antibiotics, mucokinetics, pe
ur from an infectious disease, half of whom are children under 5 years of age. Infectious diseases account for 26 percent of total global mor
diabetes therapy. Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In t
drug targets for many major diseases such as neurological diseases, cardiovascular diseases, cancer, autoimmune diseases and diabetes. T
two years has increased the throughput of voltage clamp ion channel assays by a factor of at least ten. This is possible because the automa
with low vision that uses computer vision algorithms to search for, detect and enhance targets such as text and faces to aid in everyday task
roblems, with shoulder arthritis as one of the most common. Shoulder replacement surgery, also called total shoulder arthroplasty or "TSA
unomodulatory effects on many cell types. Recombinant human interferon-gamma is approved for the treatment of chronic granulomatou
essive joint destruction, deformities and disability. One of the earliest observed features of RA is the development of a new vascular netwo
ors suitable for use in commercial ophthalmic adaptive optics. They will be designed to permit diffraction-limited retinal imaging through d
ude pulmonary embolism (PE) remains an unmet need, especially for patients with conditions that activate infammatory and coagulation p
roblems facing the health care industry. Of the approximately two million hospital acquired infections reported annually in this country, ab
s a microbial infection caused by a limited number of cariogenic bacteria (i.e., Streptococcus mutans) that co-reside with over 400 other no

research tool which addresses core technical challenges in the field of proteomics, including protein-drug interactions, protein-protein inte
eagentless Pharmacoproteomic Measurement (RPM) high-throughput technology to identify biomarkers of response to environmental stre
chnology to determine protein CAM/metabolite binding as a means to determine adherence to CAM regimens in NCCAM clinical trials. Cald
cterized by the progressive loss of motor neurons. The worldwide prevalence of ALS is estimated at ~87,000 patients, in part due to the low
soacompeting
complex multifactorial disease with
optical and non-optical no known
imaging disease-modifying
modalities. In addition,therapeutic treatments.
CRI will work on methodsDJ-1
to is one of the
accelerate most
time frequently
consuming mutated ge
tomographic
ems will be developed.
s detection of active signaling pathways, benefiting pharmaceutical research in the selection of patients for better targeted trials and in the
tics).
mple, literature estimates that 30-50% of all skilled nursing facility residents are chronically dehydrated, with resulting cost to the medical s

undertaken in collaboration with Baylor College of Medicine (the home to Kardia's founding scientists). The project will accelerate the dev
 ticles for Non-Hodgkin's Lymphoma Treatment" are to (1) develop a novel, surface-modified PLGA nanoparticle system for the targeted del
saturation (SctO2) continuously and non-invasively at the bedside. Complimentary to pulse oximetry, which only measures arterial oxygen
ative consequences among college students indicates a pressing need for evidence-based alcohol abuse prevention programs with adequa
ng A immunization, non-steroidal anti-infammatory drug (NSAID) administration, and manipulation of microglial activation states have all b
ed periods has been demonstrated in recent clinical studies. However the need for 2-3 donor organs per transplant means that less than 1
el processes and devices in the area of biotechnology and medicine. CPSI research strategy focuses on understanding and manipulating the
n developing new and innovative approaches to the use of chilling and freezing temperatures in support of the cell therapy and cancer are
n developing new and innovative approaches to the use of chilling and freezing temperatures in support of the cell therapy and cancer are
ational modification with a potentially prominent role in cancer biology. However, despite advances in proteomics, it is still difficult to find l

r substrates are important regulators of signal transduction pathways during normal growth and development as well as during oncogenes
idic cell culture array for high quality cell-based life science applications in the pharmaceutical and biotechnology industry. This will focus o
more difficult post-genomic challenge will be the functional annotation of all human genes and integration of this information into a rationa
more difficult post-genomic challenge will be the functional annotation of all human genes and integration of this information into an opera
more difficult post-genomic challenge will be the functional annotation of all human genes and integration of this information into an opera
man myeloid progenitor cells to attenuate radiation-induced gastrointestinal or hematopoietic injury. Radiation (XRT) remains an important
ruses. When coupled to a solid support such as magnetic particles or agarose, the polymer could be used to isolate and concentrate fu vir
tion of new infections and the care for those who are living with HIV. Highly active antiretroviral therapy (HAART) which has dramatically im
an increased risk for the ventricular arrhythmia torsades de pointes and sudden death. Recognition of this condition has led to increased fo
l, at a rate of about 4 errors per day in a pharmacy filling 250 prescriptions daily. This translates to a gigantic amount of 51 million prescripti
ble, yet sensitive, spectroscopic detection. Combined with novel optical detection tags based on surface enhanced Raman scattering (SERS)
es, and potentially rewarding efforts, in medical imaging. To retain the traditional benefit of ultrasound, visualization of dynamic biological
n the United States, and is a leading cause of death. Intravascular ultrasound (IVUS) has begun to make a significant impact in diagnosis an
sential for antibacterial activity, the megalomicins (which differ from erythromycins solely via an additional sugar attached at C6 of the ma
and digitoxin for treatment of breast cancer and recent reports suggest they may be especially useful to treat non-small cell lung cancer. T
betes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of dono
boratory test in the United States and the world. A new technology for the CBC is proposed, which produces a monolayer of whole blood a
tics, pharmaceuticals, pesticides, cosmetics, food additives, etc., are endocrine disruptors (EDs). EDs interfere in various ways with hormone
a leading cause of blindness in developed countries. Abnormal angiogenesis in the retina or retinal neovascularization (NV) is one of the m
ng cause of blindness in the world. Diabetic macular edema (DME) and retinal neovascularization (NV) are the two major pathological alter
early feature of diabetic retinopathy (DR) and can lead to diabetic macular edema (DME), which is the single greatest cause of vision loss in
e world. Human disease is acquired primarily through contact with water contaminated with the urine of infected wild or domestic animals
ical and morphological properties of the tumor, leading to generic and often unsuitable treatments for patients. Recent genomic advancem
ed for the addition of CO2 to acetyl-CoA to make malonyl-CoA. In mammals, malonyl-CoA serves as a precursor for the synthesis of fatty ac
wide as millions of human beings have been exposed to excessive arsenic through contaminated drinking water. The serious toxicity of ars
ns a major cause of infant mortality and morbidity. It is also a significant economic burden on society costing several billions of dollars a yea
e Culturally Sensitive Healthcare), a low-cost desktop-computer-based product for training culturally sensitive healthcare delivery. TEACH w
clinical diagnostics system for monitoring normal and diseased immune function that occurs in the context of infection, infammation, asth
a complex challenge that combines the interpretation of a range of physiological cues and molecular assays. Traditionally, radiography has b
es and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention for T1D is o

ntly reduce technologist time and speed EEG procedures. This electrode will make EEG more practical in emergency situations and reduce
fying, analyzing, and presenting multiple symptoms related to the diagnosis of Parkinson's disease (PD). The clinical system will aid in early
ry, pathogenesis of chronic neurological diseases involving BBB dysfunction (e.g., brain tumors, ischemia, hypoxia, brain edema, multiple sc
nntia andmodules,
of our most of them arestudents
medical cared forwill
at home byto
be able a loved one. interview,
effectively The negative impact
assess, andofprovide
caregiving for treatment
proper someone with dementia
to patients has
with been well
alcohol use dd
roblems.
 children and adolescents presenting to emergency departments (EDs) for psychiatric issues. Given that youth mental health issues accoun
gonists for the treatment of psychosis and cognitive dysfunction associated with schizophrenia. Cognitive deficits, including impaired mem
osition of the amyloid a-protein (Aa) in brain is a prominent pathological feature of Alzheimer's disease (AD) and related disorders. Fibrillar
ne whether administration of an apoE mimetic peptide, COG112, improves clinical, histological and infammatory outcomes in clinically rele
ects approximately 500,000 people in the US and an additional 50,000 are diagnosed each year. This disease is characterized by tremors in
aths each year in the United States. Sepsis syndrome results in multisystem organ failure due to a systemic infammatory response and acti
ng adults that is pathologically characterized by infammation and demyelination in the brain and spinal cord. More than half of MS patient
disorder of the central nervous system (CNS). Currently, there are no effective treatments for Primary Progressive forms of MS (PP-MS) and
growth. Small bone and joint problems account for 51% of office visits to orthopedic surgeons and 24% of surgical procedures. Fixation of
hich would satisfy the surgical need for a strong, easy-to-use adhesive to adhere planar faps of tissue. This novel adhesive will reduce fuid
urveillance and isolation, a sufficient supply of antiviral drugs, and rapid development of a protective vaccine. Under optimal circumstance
ining system for learners of English as a second/foreign language (ESL). It is well known that interference between a learner's native langua

ation and
control vapor separation
samples. We believethe combination
that of high
CNW's custom membrane
reagent kits for permeation and high
the QMS system membrane
will provide separation
more when
predictable, evaluating results
reproducible isopropyl alco
from s

bsorption of glucose from the GI tract. Inhibiting glucose uptake in the intestines and/or promoting glucose disposal in the tissues may be
nd signaling pathways. This proposal seeks funding to provide a platform for aggregating, analyzing, and presenting this genomic data to d
and development.
dardized outcome assessment protocols and instruments with known reliability and validity. At present, there exist no protocols and instrum
sensitive and selective, broad band, real time data acquisition, GPS enabled and remotely accessible by wireless or by internet a "Personal E
(National Center for Health Statistics, 1986; Stucky, Gold, & Zhang, 2001; Winterowd, Beck, & Greuner, 2003) and is a major source of disab
d Poisson-Boltzmann equation (mPBE) will be computed an order of magnitude faster than currently possible. The effort builds upon a pre
elding technique to close corneal wounds, provide a foundation for innovative treatment of eye disease and demonstrate the unique prop
r eyelid and examine the color of the inside lining of the eyelid, called the palpebral conjunctiva. While a qualitative inspection of the palp
nited for
table States;
highfor whichproduction
volume the basic treatment is surgical excision
of metal microstructures. Theofgrid
hardcanand
besoft tissues of the
manufactured at face. Tumor excision
competitive cost andmay
madebebroadly
combined with rat
available
oftware to make more correct interpretation of the images, leading to a reduced number of false positives and false negatives and saving li
nology used to assess function and disability in older adults. The proposal responds to NIA's stated priority listed in PA-04-064 to "develop
dentified the need for a lift device to help people in wheelchairs, who cannot or have difficulty transferring independently, transfer from a
ools that are relevant to patients' experiences and customizable to their individual conditions. This need is created by market changes whe
gmaintaining strengthimmobilization
during post-surgical and endurancefollowing
of pareticsurgical
musclesrepair
and aiding
of the in restoration
anterior of functional
cruciate use of the
ligament (ACLR) affected
or total kneelimbs. One relatively
arthroplasty new
(TKA). Qu
There are approximately 100,000 ACLR and 400,000 TKA surgeries per year in the United States.
nd cost-effective methemoglobin sensor. The long-term objective is to develop a commercial-grade sensor that provides realtime, point-of-

antibodies being developed

vertebral fractures and FDA-approved,
and 250,000 wrist fractures. there is a clear need
Notwithstanding forfacts,
these improved cell line development
osteoporosis to support
is under-recognized recombinant therapeuti
and under-treated. The prop
d to earlier detection and treatment and ultimately to reductions in the number of fractures.
ndous social and economic cost. While prosthetic joint replacement is a well-established procedure, a finite life span makes this treatment
nt melanoma. This proposal will promote the development of a High Throughout Screening (HTS) system for assessing cell mediated cytoto
CYP4X1. The CYP4X1 mRNA and protein are highly expressed in neurons of the CNS and is ~80% homologous between mouse, rat and hum
ssels has the potential to treat a wide variety of disorders including acute and chronic myocardial ischemia, peripheral limb ischemia, and t
ucture in developing a detailed understanding of the molecular basis for life and for disease. Tools for the identification of means for interv
al is to develop Supporting Transition In Vocation and Education (STRIVE) postsecondary transitional support training materials for use in sp
develop Confict Resolution for Recovery and Relapse Prevention, a 12-session, multimedia psychoeducational curriculum for adult substa
urrent pulling out of one's own hair resulting in noticeable hair loss. This impulse-control disorder includes an increasing sense of tension i
al is to develop and evaluate the Family Engagement Training Program (FETP)-a Web-based innovative, comprehensive training resource fo

sal is to continue the development and evaluation of Youth Living in Balance (Youth LIB), an innovative, comprehensive psychoeducational
esearches. The data could come from longitudinal community surveys, genetic family studies or spatial-temporal studies to investigate som

ghting for breath and losing. Until recently, CF patients succumbed to this fatal, inherited lung disease as infants, young children or adolesc
e entire family. Disruption of family, work and personal life, and the burden of worrying about the well-being of the person with BPD, are a
ent and evaluation of Making Smart Choices (MSC), an alcohol prevention curriculum designed to educate adolescents in grades 7 and 8 ab
drug, are novel camptothecins that were designed to be used in the treatment of childhood neuroblastoma. These CPT analogs are lactone

ve training module, "Dementia Care: Sleep Behavior Disorders" targeting formal caregivers in nursing homes and assisted living facilities as
patial Modeling China is experiencing a rapid transition from a central planning economy to a marketing economy. Tremendous changes are
em for performing periodontal minimally invasive surgery. Periodontal minimally invasive surgery (MIS) is a method for regenerating lost bo
ago to prevent driving under the infuence among patrons of public drinking establishments, from which half of DUI arrests and alcohol-rel
ental health issues, such as oral manifestations of eating disorders. Anorexia nervosa, bulimia nervosa, and partial syndrome eating disorde
health problem brought on by the spread of chloroquine-resistant malaria. To address the need for an orally available and inexpensive rep
er characteristics of local 60 plus populations in greater detail than is currently possible. The NEED-PLUS project ("Neighborhood Estimates
e rapid test for hepatitis B virus (DRW HBsAg Rapid Test) that will be useful as a diagnostic test in the United States and Europe, and as a pr
ributed to over 224,000 deaths and the total cost of diabetes was $132 billion. A worldwide epidemic of diabetes is now projected which w
omparing the protein composition of biological samples. The technology, Differential Capture Proteomics (DCP), is designed to circumvent
th HIV/AIDS will be designed. The long-term goal is to expand the system to motivate adherence across multiple chronic conditions. Phase
ve of SPIMA is to create a phone-based system that longitudinally and remotely assesses the mood of patients suffering from major depres
rowth factors and because of their role in disease, they have been a major target for the development of novel therapeutics to treat cancer
growth factor receptors are activated by ligand induced homo or heterodimerization. Because of their role in regulating cellular functions a
SB) transposon system as a non-viral means of integrating new gene sequences in cells and tissues for therapeutic purposes. Here we prop
y the absence of any of eight different proteins that regulate DNA repair. Affected individuals suffer from bone marrow failure early in life.

ses in U.S. The monetary cost of occupational hearing loss is staggering; for example, the cost to the military for compensation for hearing
nchocerciasis), infect over 140 million people with up to one billion at risk in at least 80 countries and territories. Lymphatic filariasis (cause
se in a whole- slide scanner to rapidly generate virtual slides in pathology and cytology. The primary use of this optical system is to enable u
tic assays used for detection and quantification of genomic material. For a genomic assay to be effective, it must be both highly sensitive a
mensional radiation dosimetry for radiation therapy treatment quality control. Radiation therapy requires that radiation dose be applied to
ble-tuned, cryogenic, cost-effective, MRI rf coil platforms, especially for improved MR spectroscopy (MRS) in pre-clinical studies in small an
x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had limited success on the insoluble proteins that a
ble with 5, 3, and 1-mm tubes used in liquid-state Nuclear Magnetic Resonance (NMR) spectroscopy. Each aim in phase I is directed toward
or for intraoral Dental radiography. The detector will improve intraoral Dental imaging with reduced dose, high resolution, and low detecto
snce
fortomography
x-ray CT scanners based on
(FT) system. Thishigh-throughput
new technologyphoton-counting
will create a newcadmium zinc telluride molecular
type of dual-modality (CZT) detectors combined
imaging. with CMOS
This project readout
will create newarc

of systemic blood pressure (BP) is lost post-stroke and traumatic brain injury (TBI). Noninvasive bedside methods are urgently needed to ide
y altered to support complex natural product biosynthesis improve the success of screening environmental DNA libraries for novel and usef
he diamond machining of the materials that are not conventionally considered to be diamond machinable. Ultraprecision diamond machin
aluating the amount and quality of weight gain, which can provide key information in both clinical and research settings. Thus, body compo
es with the healing process and can lead to systemic infection, limb amputation, or death. Compounding the problem is an inability of the c

uring growth, transportation, or storage. Contamination of food and feed by mycotoxigenic fungi is an important agricultural and national s
nfection of the gingival and the associated infammatory response. Recent studies estimate that between 35 to 45% of adults in the US hav
RY: The human secretory leukocyte protease inhibitor (SLPI) is an 11.7 kDa mucosal protein well known for its anti-microbial (including anti-
ation (structural genomics) and in subsequent drug targeting (pharmocogenomics) is the acquisition of soluble correctly folded functional p
fficacy of using an interactive multimedia (IM) format for providing comprehensive vocabulary instruction to students with high incidence di
 ectronic measurement of individual bases. The method utilizes a protein pore in a newly discovered suspended lipid bilayer configuration
functions. Medical researchers are discovering tens or hundreds of new channelopathies per year as many diseases are being recognized t
erved market that is rapidly expanding in the United States, and there are currently only a limited number of products for middle school lif
ure monitor or used for urinalysis is proposed for real-time monitoring of pesticide exposure. This sensor, coupled to a battery operated rea
tion of protein concentrations in clinical and biological samples is proposed. The proposed approach employs nanotubes with molecular si

d for MRI quantification of postinfarct myocardial viability using a commercially available contrast agent Gd(DTPA). The commercial embod
data for performing a Functional Behavior Assessment (FBA) in schools focusing specifically on children with autism. The proposed archivi
pounds with high potential for drug development for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). The starting ma
oing dialysis is steadily increasing. While the population undergoing dialysis, presently at about 400k in the US, is growing along with the gl
on Practice project addresses an important but little discussed weakness in the current technology of transferring research-based findings t
This Phase I SBIR proposal focuses on important practical issues that currently inhibit the development of data-based decision systems that
hat they want to say in a way they choose to say it. VG gives AAC users the means to control how their voice sounds to others, thereby esta
re-excision surgery due to incomplete removal of the cancer during the first surgery. Needing a second surgery means increased cancer re
irculatory system consisting of abnormal and direct connections of arteries to veins. Endovascular embolization, as a recently emerged clas
tion; with a rupture rate of approximately 1% per year. This translates into approximately 30,000 cases per year in the U.S. It is estimated th
llulartostructures
bine provide a at resolutions
uniquely well beyond
powerful what can
(but typically largebeand
achieved in optical
expensive) microscopes,
research and with
tool. Our goal much simpler
is to develop sampleA preparation
and market Compact Softthan
X-R

monitor which combines a novel aerosol concentrator, a micro-particle collector, and a microfuidic sample processing and detection platfor
ld analytical
he instrument
characterization for electrochemical
of sensor performance inmonitoring
the presenceof arsenic in drinkingvapor.
of formaldehyde water.The
This programapproach
proposed seeks to provide a newdesigned
is specifically avenue totolaborat
protec
atform can be readily adapted for indoor air quality or environmental monitoring applications as well.
g Phase II. The personal monitor developed under this program will provide real-time detection of organophosphate pesticides. Cost-effecti
abilities will provide employers, regulators, and researchers with reliable exposure records.
touring museum exhibit featuring a virtual reality (VR) environment for teaching about the impact of drug abuse on the brain. The exhibit
mal mice. Our hypothesis is that this is most likely due to the shaping of their immune repertoires by the murine Rh homologue, and that t

hma and chronic obstructive pulmonary disease (COPD) constitute major health problems in the US. Mechanical ventilators are used increa
ause of its anatomical, genetic and biochemical similarities to the human. It is also used for drug screening, production of antibody and pro
000 of which are recurrences, carrying with them a two-fold increased risk of death. Recurrent MI take place owing to the high rates of reo
reening technology for multiplexed characterization of the secreted protein from individual live cells, enabling detection and propagation o
l, highly concentrated, immunogene therapy against brain tumors. The therapy incorporates a specialized polymeric delivery system (PPC)
oorly understood affliction of the ocular surface. As a multifactorial disease, dry eye has hyposecretory, auto-immune, infammatory, horm
ntrolled cellular proliferation. Importantly, there is evidence that splice variants of certain genes, and their respective ratios are significantl
ndividual's is immense. Currently, the cost of CD4+ counting is a major issue (especially) in resource-poor environments, where the infectio
a tuberculosis (TB) vaccine. We detail a novel multivalent strategy that aims to elicit immunity to prevent reactivation of latent TB. This epi
the very therapy they require: Factor VIII protein replacement. Up to 30% of all hemophiliacs and greater than 50% of severe hemophiliacs
of the vital physiological interactions that depend on the chiral orientation of molecules. Preliminary results clearly demonstrate that by mo
onsequences to individuals and society. The current methodology used to measure ethanol concentration in breath relies on decades old t
ose to design and deploy a handheld breath-based "personal" medication adherence monitoring system (MAMS) which will meet the crite
nually. The hallmark of the disease is the accumulation of plaques in the arterial wall. These plaques form when macrophages are subjecte
ch spending in drug development was focused on kinases. Kinase inhibitors are being sought as targeted therapeutics for diseases from can
ft tissue 'fill' and/or symmetry. Specific examples include congenital malformations (e.g., hemifacial microsomia and Romberg's progressive
operation and correlation of the two types of images, and test the system in phantoms followed by clinical evaluation in 12 patients with br
cial development and the process of FDA approval.
se (FAS) as a potential diagnostic and therapeutic target for human cancer. These notions are based on two fundamental observations: [1] F
"industrial" metabolic engineering, is a method for performing strain improvement in industrial microorganisms by harnessing the power
malonyl- CoA, is the limiting factor for improved erythromycin production. As such, the methylmalonyl-CoA metabolic node has become a fo
ed blood levels of bilirubin (hyperbilirubinemia) associated with jaundice pose a significant risk for neurological damage. Current diagnostic
ion people in the United States with known diabetes. Diabetic patients commonly demonstrate impaired wound healing. Approximately 20
w and innovative strategy to allow a DNA or RNA target in a biological sample to assemble its own template under conditions of dynamic e
(volcanic activity, forest fires) is omnipresent. However, human activity since the industrial revolution and the advent of the internal comb

can be used to remove language barriers between nurses and non-English-speaking patients in a hospital setting. In Phase I, the hypothesi
ng dissociated cells into a biodegradable polymer scaffold upon which new tissue forms. Better means are urgently needed to compare eng
ve scale syntheses of high purity peptides and oligosaccharides utilizing some of Fluorous Technologies' (FTI) proprietary techniques - fuor
lle High Throughput Intracellular Drug Screening Platform Rapid well-controlled intracellular delivery of compounds into a cell - without pe
children are still not succeeding in school (Powers, 2005), and school failure is strongly associated with race/ethnicity and SES. School succe
he most prevalent form of glaucoma, primary open-angle glaucoma (POAG), increased intraocular pressure (IOP) is the most common risk
heath and an unprecedented challenge to drug development. Most HIV-1 drug development has focused on viral targets. Unfortunately, giv
gh-RF-technology company with an outstanding core of technical personnel, Future Instruments LLC has the mission to be the first industri
ns are used in both men and women, and in addition to their use in treating primary (or secondary) hypogonadism the potential benefit of
n in response to Pharmacologic Agents and Drugs for Mental Disorders (STTR [R41/R42]). The goal of this proposal of 1 year's length is to id
vide situation awareness of the current defense status of large-scale networks during 24/7 operations. This includes assessing the impact o
ng made of AMM materials guides waves around and away from a “cloaked” internal region, rendering the object inside undetectable by a
trator sensor that identifies the material being penetrated and also correlates strongly with its underground trajectory. Such a sensor woul
will reduce overall design costs and time from concept to market. The Toolkits will be heavily infuenced by devices incorporating single cry
st engines for Naval use, yet have specific roadblocks to development such as precise delivery of fuel, in location, droplet size, and quantity
network of FPGAs and embedded general-purpose CPU blades. The TIPS works in tandem with a cryogenic RSFQ-based sub-system to form
the shock phase followed by a long duration pseudostatic loading that depends upon room venting. Add the possibility of additional impu
will support four critical receiver functions: 1) very rapid carrier acquisition and time synchronization; 2) adaptive signal processing to mitiga
ibution design enabling secure unicast and multicast operations at the network layer; re-keying both layer-2 and layer-3 multicast groups, a
meters. The evaluation of advanced gear material processes, surface finishing and surface treatments, like laser peening, are proposed. Th
urpose of the BRDA is to provide real-time information as to the probability of above water visual detection of platform-induced (e.g. an Au
fzone Water Attenuation Node) drifter that will measure beam attenuation, log GPS, and wirelessly telemeter this data using inexpensive w
which to perform comprehensive surveillance. A cluster comprises one supernode and up to 65,536 nodes, all of which are within the com
utages occur with durations being a function of mobility patterns and suitability of protocols in handling such topological changes. Establish
Problems are frequently discovered in the hardware/software prototyping or fight test program phases, when they are difficult and expens
sure temperature at specific locations in the fow path and on the surface of the combustor liner to determine both radial and circumferen
dology that should lead to the realization of an affordable DBF for a large phased array (thousands of elements). Compared to analog beam
tested to evaluate the performance improvment and the factors affecting that improvement. The best improvements will be used in Phas
ffective in detecting or responding to even known exploits due to the polymorphic and metaphoric nature of advanced malicious code. In
pproach to rocket ignition using LOX oxidixer with either kerosene, methane and hydrogen fuels. The proposed development effort will focu
tise in fire detection, wireless technology, and low-power systems to solve all of the fire suppression issues in aircraft. These advances will
and other applications where very low power consumption combined with fexibility is desired. To address fexibility in radios, Williams-Py
he resulting increased electrical demand placed by all of the command and control, intelligence, communications, surveillance and reconn
on a centralized architecture for surveillance applications. Point solution systems use a single control agent to coordinate the actions of the

d. The crash performance of troops in seats based on the novel design will be simulated.
on a next generation airborne ISR aircraft. XTI will evaluate FORL systems using conventional and advanced techniques employing state-o
te a Wideband RF recorder with well-defined communication interfaces for three major subsystems - acquisition, storage and playback. Sca
n increase in performance and maneuverability for microthruster technology compared to cold gas or monopropellants. The proposed pro
ed for stable combustion is very low. Compared to nitrous oxide and ethane, this combination has higher density, and a greater range of sto
high speed machines of particular interest to the aircraft community, it has been suggested that the losses could be as high as 10% to 15%
evelopment, porting, integration, debugging and analysis of waveform software. This tool suite is comprised of two tools, a Core Framewor
ound demonstrations and other activities. This will include the insertion of specific AFRL ORS technologies and vehicle design features into
sion rehearsal applications. The proposed display component is an eye protection goggle type wearable high resolution stereo display. Wit
e upon the state of the art of security policy analysis and composition of large systems. This will advance the state of the art beyond devisi
mplementation level and the resulting complexity leads to expensive an inaccurate system characterizations. A need exists to provide repr
main, safety, dependability and system certification activities represent what can become a formidable task in each development spiral. As
fit within the size, weight, and power envelope of a small UAS, is robust and includes several onboard real time target detection and data
ethodologies concerning UHF SATCOM frequency Reuse, • to establish the Reuse methodologies and the analysis approaches, • to demon
OM terminals. The toolset will accurately model the end-to-end performance characteristics of SATCOM systems including the Navy’s Comm
opacity measurements unfortunately are constrained by two limits: First, the observer must be located between the sun and the target plu
so act as homing beacons for the feet. Few air-deployed dropsondes are deployed—usually only in hurricanes by specially-equipped WP3
tigating potential IntServ signaling protocols &#61607; Aggregate RSVP with pre-emption &#61607; RSVP Proxy &#61607; Measurement-Ba
collaboration with the University of Rhode Island, has been working on the development of innovative technologies that should result in d
veral areas: inertial and differential GPS-assisted navigation, user interface design, efficient integration of components from mainstream su
tta’s existing expertise in several areas: network security, inertial (INS) and differential GPS-assisted navigation, user interface design, above
 team to refine and complete development of the Comparative Isotope Fractionation Methodology (CIFM), a process by which stable isotop
er technology to achieve that objective which offers interference suppression greater than 30 dB, insertion loss less than 5 dB for signals of
ed are the feedstock for high kinetic energy coating processes in the range of 5 to greater than 100 micrometers. Commercially obtained c
to L band. The technique offers the capability of achieving notch bandwidths as narrow as a single legacy communications channel with e
F. The technique has minimal impact on the size and weight of ZA’s existing adaptive RFI canceller. ZA presents a second proprietary techn
he olivine-type phosphate cathodes are attractive. The stable nature of the olivine-type structure having a PO43&#8722; polyanion with a s
her development and integration of these techniques, which in combination offer interference suppression greater than 50 dB, low impact
nergy (Wh/kg). Lithium-air batteries offer the greatest theoretical specific energy for batteries at 11 kWh/kg. Yardney has extensive experien
ons of backscattering strength of electromagnetic waves scattered from ocean surface roughness modulated by the currents. In Phase 1 of
radically designed cell developed in the Phase I. Specifically, the project advances high energy density cells by focusing on increasing the e
n a Twin Otter. During Phase I ZAI will look at mounted options for other possible aircraft. This investigation will include both centerline fu
as the THz emitter, and a balanced electric-optic (EO) crystal incorporated with a quartz lens as the detector. The proposed unit will have TH
tional scanning technologies, making it ideally suited to micro-vehicle applications, unattended ground sensors, and man-portable applicati
mmend excitations. In phase I, a CartEuler-based FP/LCO methodology (CEFM) will be established with a ZONA-developed Cartesian Euler s
esign/analysis of air-vehicles and MAVs under continuous dynamic morphing The proposed methodology, called NANSI.AE, has significant
n objective is to refine the Phase-I design and build a lightweight working ADRWD prototype that can accurately measure the runway defe
tial intracavity laser absorption spectroscopy (ICLAS) which provides up to kilometer effective optical path lengths in a device with centimet
s to come. This advancement in the cell capacity will lift military batteries to the next level and will have a significant impact to the outcom
rges and high-rate discharging. The cell also incorporates a new nano-anode material to increase the energy density for both high rates dis
ng Phase I, AMT and the University of Texas CEM proposed a unique, passive, reliable, efficient eddy current brake to accomplish the same
at deuterium effectively ‘decorates’ defects in materials such as ZnCdTe and HgCdTe. In essence, the distribution of deuterium in the samp
eously providing adequate thermal protection to the hands proves futile in maintaining an adequate core body temperature in long duratio
In addition, the contractor shall work with the government selected vendor for Voice Recognition and Voice Synthesis and evaluate the in
ed. This rugged system permits user controlled tuning of key optical, electronic and thermal/mechanical parameters which are necessary t
on over indigenous libraries. The approach is based on an innovative built in current sensor (BICS) technique designed to provide portabilit
hermore, we have performed a detailed study of the ability of the PLADAR system to see parts of a scene that are not visible under intensit
ecise and selective removal of the desired coating layer while preserving any underlying coatings and the base material. The instrument’s
ansfer the heat generated to water. The device will be packaged into an immersion-style heater. The heater will come with a matching cup
eight low profile crane, boom end mounted robotic effector, novel hose end connection and receiver port design, and hierarchical comman
red focal plane arrays (FPAs), and reduce BMDS life cycle costs. HgCdTe is clearly the material of choice for these IRFPAs, but presents num
quirements. The hydride is thermodynamically capable of releasing pure hydrogen at less than 80C. Quantitative demonstration of increas
ulators that do not utilize a motion base, and logistically it is largely not feasible to maintain a simulator with a motion base in a deployed s
. A dominant contributor of the noise is due to the air-cooled heat exchanging system that draws a large volume of air through a compact s
n, tissue breakdown, and pain. The volume of the residual limb of an amputee changes throughout the course of a day and throughout the
ic boot offers lower weight, fexibility, abrasion-resistance and field repairability. To date, these have failed due to sand and rain droplet im
e transmitted by insects. There are no prophylactic vaccines available for these diseases. Soldiers must integrate multiple personal protectiv
plemented in hopes of reducing injuries, but the modern trend has been to mount all the critical information and symbology on the helme
er mixed oxidants to neutralize potentially harmful biological compounds. Although oxidizers such as sodium hypochlorite are readily-availa
malian prion protein, PrPc. Normal disease transmission occurs when prions are ingested by a naive animal. The current test for TSE is a po
clear materials in particular has sparked considerable debate and is a cause for concern on the international stage. An effective system mu
n fow between any two communicating entities should be protected properly against various malicious attacks, specifically the exploitable
ctor in the intensity of sound experienced by a subject is now in large part determined by the sound conducted through bone in the anato
d by any degree. (b) A retractable sliding track, mounted on the turning table, allows the seat to move in any direction by as far as 4 ft. (c) A
emperature changes and be hardened to ionizing sources of radiation. The tolerance for these properties are restricted even further when
ot this information has either been lost or is not available. In this project, we plan to develop the technology that will make it possible to ex
ned with single or dual receiver channel SAR data processing to detect, track and image moving targets in real time. For this purpose, we p
ctors that can be printed on or embedded into composites without degrading their structural performance. The benefits of this approach in
 t aptamers. A laborious, yet automated process is required to isolate the desired molecules, thereby precluding their widespread use. Infos
ction, airfow performance, and thermal signature. In this Phase II program, Infoscitex (IST) will continue the development a novel composi
aded off in Phase I. The baseline proposed approach balances front end innovation and advanced back end processing techniques to evolv
ase I, we developed Monte Carlo-based methods to predict the mobility of the PackBot on steps, and we experimentally validated those m
on from the data generated by strain-gages and blade-tip sensors in turbo-machinery tests, either on test stands or in spit cells. This goal is
G and mortar attacks, small arms fire, and vehicle rollover incidents. The use of an effective decision-support mission planning tool that pro
hile each carry a supply of liquid and are trained to stay hydrated, it is difficult for soldiers to gauge how much liquid they have left, leading
d are extensively employed throughout the DoD. It is therefore critical to protect these technologies and avoid their exploitation in such a
fight sensations and maneuvers previously impossible, we propose to improve centrifuge training. Specifically, we will tackle the issues of
oth in terms of mission readiness, and labor and materials cost. Infoscitex has developed a combination functionally graded, multilayer coa
harvesting approach is viable and could potentially be expanded to harvest energy from both low frequency kinetic sources such as ocean c
uch as vehicle mounted locators). Manufacturers of orientation and tracking monitoring sensors utilize redundancy and complex algorithm
trained in social science research methods. Within the Department of the Navy, potential users include Naval Special Warfare, Marine Spe
tion of non-aqueous electrolytes to realize the benefits of this chemistry has resulted in limited success in terms of providing a long endura
Solar cell arrays can be disabled or damaged during a high power directed energy attack. In the proposed Phase I program, Infoscitex will
ility and air refueling aircraft do not wear fight helmets although they must be able to use these HMDs during their missions. Similarly, gro
hermal conductivity (TC) controllable over a range of 600 to 750 W/mK and thermal expansion controllable over the range of 7 to 3 ppm/K.
hermal conductivity (TC) controllable over a range of 600 to 750 W/mK and thermal expansion controllable over the range of 7 to 3 ppm/K.
ro systems monitoring the activity and threshold of nociceptive fibers under basal conditions and after exposure to infammatory mediator
h the frequency breadth and decibel depth of protection against HPM and other electromagnetic interference phenomena.
etallic fakes have recently been demonstrated to achieve superior performance in terms of mass extinction, which likely will lead to a high
e fuel (based on the fuels lower heating value) to electricity at operating temperatures around 800 degrees C. The remaining 40% of the e
tallic fakes have recently been demonstrated to achieve superior performance in terms of mass extinction, which likely will lead to a highe
ant measurements and waveguide loss measurements on the magneto-optic polymers will be performed to confirm feasibility for both high
meric materials that would provide revolutionary performance for broad range of applications. We will design and analyze PhC modulators b
of engine bearing faults. On a complex engine with multiple components that produce wear debris, the addition of vibration monitoring ca
ores, viruses, bacteria (or vegetative cells) that are ready for a wide variety of diagnostic equipment. MicroStructure Technologies (MicroST
on reliability, while extending the useful lifetime of the high-value asset. In applied propulsion engineering research, PHM diagnostics and
on the formation and acceleration of magnetized plasmoids, the goal of the proposed research is to build and test a prototype that has the
ransmission (>15%), high on-state optical density (>4) and rapid response (nsec) are desired. Several new laser eye protection device desig
mal long wave infrared sensor (LWIR). The Sage Team will take a component approach (sensor, processor, and display) that offers the best
and determining the National Command Authority response to the threat. Since missile defense threat scenarios include attacks on theate
perations and maintenance budgets. The IAC-1044 has been designed to apply advanced signal processing techniques to identify resonance
companying software development fow to support rapid development and fielding of this technology to the Warfighter. The HyperX Techn
however is currently problematic. The overarching objective of the Phase II work is to build upon the successful proof of principle conduct
uld allow soldiers to respond effectively across an array of complex social and interpersonal contexts that increasingly characterize their mi
w defense technology development. This program will develop new physics-based computer models for incorporation into existing Core Le
tively mitigates tin whisker growth. New conformal coating materials are needed to mitigate the risk of tin whisker caused short circuits on
ctrical energy independence. At present, power is provided by carrying a large weight of batteries (as much as 20 lbs), which when added t
hing tools are currently available, decomposing and manipulating the design geometry and enhancing the topology for mesh construction
e I research to provide a comprehensive prognostics and health management system (PHM) for aircraft generators and associated electrica
real-time, sensory-updating residual life distribution estimation technique. Furthermore, the methodology allows us to develop a prognosti
al components, by layering and processing a polymer matrix reinforced with glass ribbons (micron-size glass fibers with rectangular cross se
we will employ data-driven approaches that help recognize specific appearance and motion patterns generated by moving humans. We wil
methods have been developed for determining the performance of miniature inertial igniter concepts to all no-fire acceleration profiles, in
primarily responds to susceptibility targets (i.e., ferrous objects). The main difference is that, while a magnetometer uses the earth’s field a
can deliver low packet loss, low latency, and smooth handoff solutions with minimum packet overhead. Further, our approach is resistant
ase I. These single quasi-volumetric elements provide more directive pattern, greater bandwidth, and higher gain than conventional dipole
nagement and visibility in local, regional and global environments. The system will employ a variety of technologies including active and p
simulation is important, because it takes into account factors that directly impact the ground soldier. Through continuing research, the Tas
with the current DoD mandate for tagging pallets and cases. Full implementation of the DoD mandate to tag all pallets and cases of Class V
design, model and develop carbon nanostructures based detector array for next generation multicolor IR imaging applications. The key com
r Phase I that provide performance advantages compared to currently used propellant components and have good low-temperature and h
w loads on their robotic platforms. Unfortunately no tools have yet been produced that meet these requirements and produce a viable core
ot (EATR) ™, obtains its energy by foraging – engaging in biologically-inspired, organism-like, energy-harvesting behavior which is the equiva
t, size, weight, and power (SWaP) while preserving the same G/T. Furthermore, we plan to integrate the SQIF-based LNA with HYPRES all-d
monstrated that this model-based approach can generate accurate estimates of battery age. During Phase II, we will use this approach to e
Stokes mode, the predicted NEDT is 0.13 K, resulting in a polarimetric noise level of 0.1%; polarimetric noise of this order is shown to be re
able for gun-fired munitions, mortars and small missiles. A systematic method is developed for determining the performance of each minia
nheit. This project will fill a dramatic shortfall in the current measurement capabilities for turbine engines. Existing blade tip clearance mea
with carbon dioxide gas (CO2) in addition to using light as an attractant. However, since many vector surveillance locations of importance t
duce the risk of post anesthesia c

e Northeast for decades and in 2004, NOAA National Marine Fisheries Service listed rainbow smelt as a species of concern in the Gulf of M
processors are therefore required to run at fast time constants to achieve reasonable throughput; however, this causes significant coinciden
for a high efficiency single photon detector. The key innovation is using low noise periodically poled waveguides with a long wavelength (1
pable of reliable and repeatable operations in an ocean environment. The UAS will be utilized for the detecting and tracking of marine deb
cases. Choosing the appropriate model, as well as the necessary input data to the model can be a daunting task. In this proposal, we disc
grammable array, currently digital micromirror devices (DMDs), which either transmit or block selected components of the light. the light i
state-of-the-art product design and development. The product, the Model 8686 Precision Resistance-Ratio Bridge, will have an operating c
her, we propose to implement a semantics, in the form of a syntax compiler and data set validator, in order to establish the feasibility and u
ncept study that evaluates the relative strengths and weaknesses of the two measurement systems and combines a detailed analysis of the
ommunication between SeaTagTM devices to obtain data from many animals when one tag is recovered or transmits. Deployment method

a single strand of DNA is drawn through a nanometer scale aperture. Although progress has been made with nanopore sequencing, some f
qual footing in the workplace and the education system.
rature CVD reactor, used by industry for growing high-quality SiC epitaxial thin films. Different polytypes of SiC nanowires will be grown by
ors to detect CO2 levels in the breathing gas, Giner, Inc. proposes to develop an electrochemical CO2 sensor for CCR use. The technical inno
so incorporated two-way telemetry and near real-time display of processed data. CLASP uses a profiling pump to deliver water to a fow-th
is will be based on software developed at HLS Research, Inc. for similar applications. The software will use existing propagation modeling c

ic conduits are necessary. These sensors cannot offer long term reliability. In Phase I, IOS will demonstrate the feasibility of developing a c
pawning season and, increase spawn viability. Larval rearing trials will evaluate stocking densities and feeding regimes, and improve overal
existing technology commercialized by Masscal for operating a QCM in a temperature-controlled calorimeter. Precise temperature control a
These light sources have high brightness and are spatially coherent. Recently, output to 4.5 µm was achieved using fuoride glass fibers; op
upon computer networks, as well as other use patterns which may indicate behaviors which are non-hostile but still problematic. The appl
ity of the MgO-MTJ sensor devices by optimizing the magnetic characteristics of the free electrode. By using new and novel combinations

ibility of pen rotation, which is essential to maintaining a fish pen offshore. Phase II will develop a prototype automated operations system
st sources of power for system operations and diver support. The greatest need for power is in the form of pressurized air. OFT¿s AquaPo
away. The design is simple and compact, fitting within a 5x5x7.5 cm volume. An initial lab demonstration has already been completed show
seeks to develop a microfuidic based approach using DNA hybridization, coupled with a sensitive detection method based on the use of ca
ncy, spectral resolution, filter response, and spectral bandwidth. Precision Photonics proposes to use its enhanced optical fabrication capab
m for lightning probability based upon these studies, perform basic assessment, prototype a web page for dissemination of the lightning pro
g Radiometer (HIRad), currently under development by a team of government, university and industrial partners, will require ten high perfo
decisions.¿ Never is this vision more applicable as it is to tropical cyclones (TCs). These systems pose one of the largest natural threats to
e most often academic in nature and have the added limitation of being incompatible with agency specific water management models or th
o include temperature sensors. The modules will be part of a low power wireless network. Each module will be about ½ the size of a busin
olume needed or lack the robustness for high pressure containment or in many cases, lack the repeatability necessary to ensure a reasona
t-cut" technologies. SRICO will Investigate domain-engineering patterns to reduce acoustic noise as well as techniques to optimize a thin fil
to trace it back to its origin. Alpha particle spectroscopy is widely used in nuclear forensics to assay trace quantities of sensitive nuclear ma
g the data to dynamically maintain waterway nautical charts.
ith closed circuit rebreathers, allowing the NOAA Advanced Diving Program to perform longer, deeper dives. The use of closed circuit rebre
s use self extinguishing fibers with high limiting oxygen index (LOI) to create a barrier that the fame cannot pass. A second approach create
t few years means and expertise to micromachine single-mode fiber using a combination of femtosecond laser pulses and highly anisotrop
ssed, configured, and reused by integrating with existing trusted RBAC implementations.
nt rate (MCR) than Geiger-mode APDs, which are constrained by a fundamental tradeoff between DCR and MCR: if the APD is cooled to red
vice (i.e. imager).
s in areas such as air pollution and air toxics monitoring, breath analysis for medical diagnostics, combustion exhaust research, and plasma
much wider deployment of IR imaging for leak detection, and enable more efficient compliance with U.S. Environmental Protection (EPA) a
cted in the fathead minnow. This information should enable EcoArray to identify genetic fingerprints and to use the database as a tool for i
y farm with a herd size of 50-100 heads. Although digesters are considered to be a valuable addition to a farms manure management strate
in 20 minutes or less and will require a very inexpensive, portable solid state detector system for quantitative test interpretation (readout).
creasingly vital necessity: reliable modern home heating with biomass. Subject to national and international politics, policies, and prices fo
h Phase II success and subsequent commercialization.
g adsorbent are quite different from those involved in catalytic oxidation, the hardware used is virtually identical. Thus, controlling emissio
ct chemical warfare agents was demonstrated at EIC Laboratories during the Joint Services Agent Water Monitor program. In addition, bact
sition in electrolytic water treatment systems. The team assembled by Eltron for this project has experience in electrochemistry and, specifi
asoline engines, natural gas-fired boilers and turbines, and coal-fired combustion sources. At the conclusion of Phase II, Eltron anticipates t

uited to identifying environmental toxicity because of their ability to determine both specific and global effects of toxicity. So far, however, m
President Bush called for 35 billion gallons of alternative fuel use in the United States by 2017, which would replace 20 percent of the natio
he atmosphere. As an added benefit, it could simultaneously measure PAN in the atmosphere using a method that requires neither a radio
10,000 units) electrochemical ClO2 monitor that is capable of monitoring ClO2 levels in real-time with a detection limit of 2 ppb could be u
inexpensive, disposable fow cell cartridges that can be chosen for the assays of interest. Thus, it will be possible to obtain near real-time r
equipment in electrostatic precipitators installed on small industrial boilers. The improved performance they afford would decrease particu
economic analyses and life cycle assessments to demonstrate economic performance. Based on Phase I results. technology can be develope
re granules to not exceed 1% moisture so as to assure the asphalt is capable of adhering to the mineral. Industrial sized testing trials will be
lity heat as water condensate from industrial fue gases. In this case, tremendous quantities of energy and water are lost out the stack in th
h must be stored and transported. Magnesium also is produced separately in liquid form via the electrolysis of magnesium chloride (MgCl2
o medium and large water disinfection systems as well as scale it to produce higher levels of sodium hypochlorite for wastewater cleanup.
alized. Additionally, a clean syngas produced inexpensively and efficiently from coal has the potential to compete with diesel in the autom

on by 2015. NN-Labs predicts revenue from sales of D-dots ¿ to reach $383 million by 2015.
ominated plastics in e-waste plastics. Because of this interest, the proposed technology is expected to have a strong market in the e-waste r
application of the MVCO fuel injector includes off-road diesel equipment and on-highway diesel engines. The MVCO injector is potentially a
llion gallons of biodiesel in 2006, and industry experts estimate the total production could be 2 billion gallons per year by 2015. However, e
addition, because of the inherent capability of the system, potential exists for application by industry for cleanup of toxic industrial chemica
.g., improve sustainability). Knowledge of effective GPSS characteristics will be used to develop preliminary protocols for commercial GPSS
°F and 1200°F. Conventional incinerators operate at temperatures in excess of 1600°F (typically higher). The burn temperature of burnb
h must be stored and transported. Magnesium also is produced separately in liquid form via the electrolysis of magnesium chloride (MgCl2
cted in the fathead minnow. This information should enable EcoArray to identify &ldquo;genetic fingerprints&rdquo; and to use the databa
inexpensive, disposable fow cell cartridges that can be chosen for the assays of interest. Thus, it will be possible to obtain near real-time r
.g., improve sustainability). Knowledge of effective GPSS characteristics will be used to develop preliminary protocols for commercial GPSS
sition in electrolytic water treatment systems. The team assembled by Eltron for this project has experience in electrochemistry and, specifi
in 20 minutes or less and will require a very inexpensive, portable solid state detector system for quantitative test interpretation (readout).
articularly well suited to identifying environmental toxicity because of their ability to determine both specific and global effects of toxicity.
g adsorbent are quite different from those involved in catalytic oxidation, the hardware used is virtually identical. Thus, controlling emissio
equipment in electrostatic precipitators installed on small industrial boilers. The improved performance they afford would decrease particu
alized. Additionally, a clean syngas produced inexpensively and efficiently from coal has the potential to compete with diesel in the autom
much wider deployment of IR imaging for leak detection, and enable more efficient compliance with U.S. Environmental Protection (EPA) a
s in areas such as air pollution and air toxics monitoring, breath analysis for medical diagnostics, combustion exhaust research, and plasma
asoline engines, natural gas-fired boilers and turbines, and coal-fired combustion sources. At the conclusion of Phase II, Eltron anticipates t
President Bush called for 35 billion gallons of alternative fuel use in the United States by 2017, which would replace 20 percent of the natio
llion gallons of biodiesel in 2006, and industry experts estimate the total production could be 2 billion gallons per year by 2015. However, e
ominated plastics in e-waste plastics. Because of this interest, the proposed technology is expected to have a strong market in the e-waste r
F and 1200°F. Conventional incinerators operate at temperatures in excess of 1600°F (typically higher). The burn temperature of burnboxes
creasingly vital necessity: reliable modern home heating with biomass. Subject to national and international politics, policies, and prices fo
o medium and large water disinfection systems as well as scale it to produce higher levels of sodium hypochlorite for wastewater cleanup.
ct chemical warfare agents was demonstrated at EIC Laboratories during the Joint Services Agent Water Monitor program. In addition, bact

s. In, addition, because of the inherent capability of the system, potential exists for application by industry for cleanup of toxic industrial ch

ion by 2015. NN-Labs predicts revenue from sales of D-dots &trade; to reach $383 million by 2015.
re granules to not exceed 1% moisture so as to assure the asphalt is capable of adhering to the mineral. Industrial sized testing trials will be
h Phase II success and subsequent commercialization.
economic analyses and life cycle assessments to demonstrate economic performance. Based on Phase I results. technology can be develope
10,000 units) electrochemical ClO2 monitor that is capable of monitoring ClO2 levels in real-time with a detection limit of 2 ppb could be u
lity heat as water condensate from industrial fue gases. In this case, tremendous quantities of energy and water are lost out the stack in th
t and system health monitoring. This topic fits perfectly with our current projects that are developing “smart” instrument systems for comp
ysis, source separation, feature extraction, classification, and Bayesian contextualization. These are applied dynamically to support online h
telligent control of electrical systems in combat vehicles. A new Phase II NAVAIR contract funds transition to a radiation-hard ASIC chip inst
o the connectors and at points where they have been tacked to prevent movement. Fiber cables suffer “maintenance induced breaks” whe
one issue with kapton composite is centering – it starts to unravel and kapton becomes susceptible to hydrolysis. When pulled through co
al operational challenges. Areté Associates approach can provide rapid optics detection over a wide field of regard (FOR).
g the time dependent heading angle inaccuracies common to all GPS/INS based attitude measurements. During the downward fight of a g
rces that meet the required specifications of wavelength tuning range, output power, frequency-stability and reliability. Arete Associates is
d from non-ground objects; remove outlier data; identify fat areas/pits/trenches; and characterize level, uncluttered areas suitable for a he

ndy, dusty, snowy or marine environments. Helicopter prop-wash churns up dense clouds of airborne particles that impede visibility. These
e mitigation, and an air-deployed buoy-mounted geomagnetic reference sensor system (GRSS) is a convenient operational configuration. T
the DoD to press for immediate and effective solutions to the detection and neutralization of the sniper threat. In the case of sniper detec
roliferation of UAV assets into missions, such as convoy protection, reconnaissance, surveillance, and targeting, has established an undenia
rength in the presence of natural clutter (including effects due to topography and meteorology) is difficult to predict. Additionally, relativel
st of Strapdown Semi-Active Laser seekers enable missile loadouts that provide greater stowed kill capabilities and/or time on station. Aret
me decision making ability concerning task redistribution and optimization. By using unique multi-agent system methodologies and levera
ence, surveillance and reconnaissance (ISR) ladar systems will tackle the difficult problem of detecting, identifying and imaging targets at g
efield environment. The Phase I model requirements analysis, software design and user interface elements will be used in Phase II to devel
 ploiting submarine ELF emmissions offer unique advantages over MAD and other non-acoustic methods. Teamed with USSI, Arete Associat
ut these solutions require modest-size or larger theater or national systems to collect the data that are a necessary input to the algorithms
M operations. The sensor system will be inexpensive enough to be expendable, but survivable enough to be deployed for a period of up to a
of a next-generation magnetic anomaly detection (MAD) system that will enable anti-submarine warfare (ASW) aircraft to search, localize,
ose a new and innovative approach for rapid assessment of shipping channel morphology from the kinematics associated with remote sens
opportunity-based learning in classrooms, on field trips, or whilereading a book anytime, anywhere.
ers, live role-players, and computer-generated characters into experiential learning situations that enable Soldiers and junior offices to lear
dle grades that included American Sign Language and Signed Englishdefinitions selected from the Signing Science Dictionary, developed by
by
rk mixing common
will greatly chemical
impact public hstarting materials and baking the resulting precursor material at modest temperatures; and the dispersment o

is and visualization framework that greatly improves the ability to monitor and control simulation and data acquisition systems. Concurren
t, most visualization tools are limited to one computer of a single platform in one location with one display. Sharing visualizations largely co
ed risk of infectious disease epidemics, increased foods, landslides, avalanches, and mudslides, decreased crop yields, decreased quality an
nd precision and with sufficient speed would reduce the uncertainty in the determination of terrestrial sources and sinks of these dominan
tronic speckle pattern interferometry (ESPI), whereas temperature imaging is achieved with thermographic phosphors. The proposed meth
re currently inaccessible or impractical with conventional CARS configurations. We propose to determine the feasibility of employing hollo
ace roughness can be a key indicator of the fatigue state of a component and that light scattering measurement is a convenient method fo
d software data processing suite. The principle of the method and technical feasibility of the proposed instrument has already been establis
in many operational environments, new solutions are needed. MetroLaser has developed an innovative approach for a TIL method to be a
alize turbulence and shock phenomena. Focusing schlieren systems are ideal for applications requiring a large field of view, and are the pre
range of velocities. Hydroxyl tagging velocimetry (HTV) "writes" a line of OH molecules into the fow and interrogates them after a short de
hat are not easily inspected with conventional interferometry. After examining the critical manufacturing problems and associated inspectio
nal environments, new solutions are needed. MetroLaser has developed an innovative approach for effective compensation of laser beam
s more information than merely the maximum exposure temperature as in the case of a thermal fuse. The sensor will be developed for use
a pair of laser sheets projected by two continuous wave lasers. The scanner is modular with compact components for easy mounting at mu
ror that sweeps an image of the entrance slit across the face of a large format CCD camera. The Galvo mirror system can be triggered exter
Vibrometer (MLV) with an automated data processing and software suite. The principle of the method and technical feasibility of the propo
manufacturing procedures
the use of 3D structures of have
prot begun using such components more and more in routine applications to improve optical system capability

which is essential for research oriented work. To modify speaking speed, we plan to focus on time domain time-scale modification algorithm
transformation. The project has come to grips with the feasible methods for glottal source and vocal tract conversion algorithms; thus layin
ks. Implementing
filing an effective
of an IND application. Thetactile display for receiving standard intra-squad communications is therefore useful, but we additionally pro

rorist activities can be very difficult. To overcome this problem, we must identify and utilize advanced techniques to automatically build soc
maintain tracks within the clutter of large numbers of confusing targets. Second, urban structures present obscuration problems that crea
needs; (2) is tailored to work with discrimination fusion engine algorithms currently being deployed to be BMDS; and (3) is compatible with
niques developed under Phase I of this effort for describing and solving the problems of tracking and discrimination within a single Bayesian
eir "physics kernels" and exploit very large existing code bases for the computer science aspects of the problem. In particular, our STTR pro
ms must overcome real-world challenges such as high target density, heterogeneous data sources, and communication bandwidth requirem
approach pursued by the Army for fielding its weapon, sensor, and C2 systems. It is highly modular and will allow warfighters in the field to
pe of reasoning, however, does not naturally accommodate a fundamental and irreducible aspect of our knowledge about the world: we a
bal engagement management algorithms in the deployed system is that providing good solutions to the weapon/target allocation problem
teams from assets that are on station and available. To provide this fexibility, the United States Military has been undergoing a transition
g, the need for instruction management through electronic curriculum guidance, assessment and collaboration.
onded to this challenge by undertaking enterprise-wide logistics modernization programs. Efficient data capture and programmatic data in
pon systems are collectively denoted as aging aircraft. A large number of aging aircraft in conjunction with newer weapon systems are ove
nd evaluations for students and adults with intellectual disabilities
mtop computer
disabilities thereby fostering self-determination and independence.
dled. Technology enhanced learning environments (TELEs), which could improve science education, are not being widely deployed. This Pha

sal objectives are aimed at resolving identified barriers and moving the concept towards commercialization. Specific objectives are to: (1) im
ic head pressure and as a result aid considerably in the management and practices at fow-through commercial fisheries and hatcheries.

e to the immense popularity and high value of red snapper, economic fraud related to species substitution causes consumers to lose faith
opose to develop a streamlined, reliable and scalable DNA-based diagnostic test that simply yet definitively identifies red snapper from rela
uaculture systems (RAS) is limited by the accumulation of nitrate, which can be toxic to many species, especially marine species. Thus, nitra
water and land, have minimal effluent discharge, and can be set up almost anywhere, including in cities close to major markets. These syste

of service-learning, affecting approximately 4.7 million K-12 students in 23,000 public schools. The goals of service learning generally are th
nt related to science the environment and civic engagement.

ent. Research has shown that progeny resulting from the hybridization of channel catfish eggs and blue catfish sperm exhibit faster growth,
d scan a honey bee colony, and quickly indicate the condition of that colony. The increase in efficiency of examining colonies for pollination,
significant increases in CO2 concentration throughout the grain mass and storage structure. The new sensor will be designed for placemen
delivering the data. Phase II will also include pilot field tests of the prototype sensor concurrent with data collection for the software mode
elderly, and those with chronic diseases remain vulnerable to Fe deficiency, despite Fe fortification of foods. All currently available iron supp

de. The goal of this project is to develop new assessment technologies that will allow for real-time error analysis of children’s responses th
uccessful both technically and commercially. Using commercial products, we demonstrated rapid 90% removal of water (program goal of 50
vious results in combination with key industrial partners and our commercial manufacturing infrastructure positions the program for Phase
ow cost quality food alternatives. Program will provide the agricultural industry with low cost way of making value added products.

obile device via vibration, images, and captions that identify these recognizedsounds. This efficient, wearable system utilizes existing and d

ods are derived from or the assumptions they use to characterize the soil pore structure. We propose obtaining the soil pore structure info
dntly
renewable. Microbe-based
underutilized, processes
on farms. This for seeks
research the production
to developofafuels
new from biomass
technology to represent sustainable
compact and technological
burn biomass options.
for heating In order
buildings usingtoasu
fa
roduction, and a commercial stove for automatic combustion, of biomass logs on farms. With such equipment being commercially availabl

nd South America and can lead to devastating economic consequences if not detected early. Current methods for testing require shipping s

nd generation vaccine tool that is effective and safe is crucial. The use of a vector such as replicon particles (RP) merges subunit and modifi

d TSV resistance. Two alternative approaches will be evaluated and the preferred strategy will be used to produce postlarvae to conduct on

ough assistive technology without the complexity of computer technology, difficulties with restricted/reduced funding, and the lack of prox
opulation, (2) develop a thorough understanding of institutional customer needs in reference to their employees, clients and customers, (3
ention), as well as direct sales to individuals.

atilesand
ture; emission monitoring
estimate economic of feasibility.
CAFOs is largely performed
Process utilizing
development anddownwind air samples
market assessment willcaptured in Tedlar
also include sampling
analysis bags. grains
of distillers Published studi
for poten
production at a scale that fits locally available resources and local capacity to finance and own the ethanol plant."

d today to convey the fundamental characteristics of a molecular system. This model is an inadequate representation of a dynamic system,
al software model to enable users to view changes in properties as they manipulate the molecular model in their hands.

allowing connection to modern roll-on gel type liners

 d.
vermicompost teas, identification of optimal doses and timings of applications of vermicompost teas and a thorough review of the econom
oved, cost-effective hardware and practices relative to present buried construction procedures, which do not otherwise allow for future upg

ensor provides high resolution data of saltatingparticles allowingthe determination of threshold of movement i.e.,the wind energy required
res light but, in many regions of the U.S., winter cloudiness (or a more northerly latitude) limits greenhouse productivity. Supplementing ca

ovation, Plant Root Characterization System, for use in tree research. The Plant Root Characterization System, (PRCS), employs low energy
d used most state-of-the-art approaches to root measurement and characterization. NRS staff researchers are interested in characterizing t

h online lab will be comprehensive – containing everything students need to conduct a physics laboratory experiment, including animations

e controlled DNA replication to produce hundreds of circular DNA copies of that vector in meiotic cells. Since homologous recombination is

ompared to other railcar loading operations. Feasibility was demonstrated. The boarding system will enable the loading of all passengers,
d interferants. Our second objective is to provide baseline information, under biologically relevant conditions to substantiate the use of parti
pical crop related volatiles.
print and can pronounce them. The target population is English language learners, struggling readers, or children of poverty who have smal
print and can pronounce them.

ct hosts and labor. In response, we propose developing a completely automated processes including production of improved insect host m
uccessful, the system can be adapted to use with other insect hosts or production of other microbial or arthropod biocontrol agents, the po
on, inservice education, educational research. The system will also enable immediate performance feedback and web-based data collection
nservice education educational research. The system will also enable immediate performance feedback and webbased data collection of ob
harm occasioned by usage of other rodenticides. Staron LLC now seeks to compare two potential species-selective rodenticide products to

ent to K 12 science curricula for primary instruction of concepts or for review for individual or small group practice. An example of how TIL

re sold in large volumes. The company will begin to sell products for this purpose, beginning in the autumn, 2006. However, for more soph
 st the substrate to control PH in the digester for hydrogen production will be a waste product: second the digestion and hydrogen producti
vative process would utilize a new patented anaerobic digester (patent # 6,911,149) called the induced blanket reactor (IBR). The technolo
nications resulting
chnologies in achemical
including unit thatorcan accurately
heat measure
inactivation the speed
of cultured of passing
pathogens vehicles
or live and relay
attenuated thisofinformation
strains pathogens.toWhile
adjacent
somebarrels andvacc
of these the
hogen, Flavobacterium psychrophilum. F. psychrophilum is the etiologic agent of cold water disease which affects commercial aquaculture s

ood and the development of metabolic acidosis in transport-stressed swine. Modification of dietary electrolyte balance prior to handling in

urce with 1000hrs of continuous operation at 1E8 n/s. The Ph I program will demonstrate the critical features of the source including pulse
d by criminals, however, frequently attacking these files requires mammoth amounts of CPU power achieved only through the coordinated
n excess of 100 meters, if needed, and supply facial depth resolution of < 2 mm. This aggressive goal is enabled by the DOD investment in 3
microseconds with a fall time of less than 1 microsecond. High pulse repetition rates and high peak neutron yields can be otained dependin
ough to affect the Homeland. The team of Advanced Acoustic Concepts (AAC) and Sparton Electronics has provided a solution to this deepw
pped inside. The Jaws of Life were originally designed for race track use but have since become a tool of rescue crews everywhere. Hale Pro
ogical materials and identifying breaches in security is required. Ideally, existing passive surveillance technology would be used, thereby en
re, which may be compromised, and should operate in both land (e.g. border security) and maritime (e.g. coast guard) environments. A de
me coupling to a hand-held ion mobility spectrometer-based detector. This non-contact sampler will be easily retrofitted to commercially av
toringThese
tions. technology and business
collective meet its objective
rules will by
be developing a PCIfor
the foundation card thatmiddleware
a new combines coprocessor based firmware,
product to optimally deploy reconfigurable computing
multimodal biometrics. an
The
gies, this will create a viable real-time non-contact screening technology for explosive materials of unprecedented performance. We have a
would be applicable to inspections for explosives, narcotics, biohazards, accelerants, and industrial toxins.
in relies on stealing radioactive sources from the legitimate before mentioned institutions to build radiological dispersal devices (RRD). Now
with the overburdened first responders and unreliable communication infrastructure, the lack of accurate and timely information creates a
in recent years, especially since the events of September 11, 2001 and its aftermath. Gamma ray spectrometers are an important tool in ho
ction and interdiction of a nuclear weapon is a national problem that has not been yet solved. This represents an enormous challenge to c
ince the events on September 11, 2001 and its aftermath. One way to passively determine the presence of nuclear weapons is to detect an
se width, low source neutron energy, high yield and be based on non-radioactive materials. Applied Nanotech, Inc. (ANI) proposes to devel
ANI worked with development partner Sionex, Inc. to establish proof of concept for basic functionality of the CNT ion source technology, de
it in a secure and timely fashion. The traditional approach to implementing secure boundary controls across networks relies on strict physi
tion of small molecule gases with reduced signal drift and extended lifetime. In addition, through chemical functionalization of the SWNTs t
is tailored to disrupt the computation functions of the vehicle engine controller, safely slowing and stopping the vehicle. Inducing a car to s
y hardware-based, will provide dramatic increases in speed when compared to purely software-based solutions. In addition to being able to
ill determine by proximity which of the responders that are available can be first on the scene. Therefore, a system that can do that based
n enhanced boundary control and inspection capability suitable for Homeland Security organizations exchanging inter-organizational email
ection of malware is done through decoy and inline network prevention system to capture target malware and scanning malware without r
nts for small, portable highly effective vehiclestopping devices. Mechanical stopping technologies must consider the kinetic energy of the v

ypt files intercepted by Department of Homeland Security Law Enforcement Agencies. Luna s unique combination of experience in securit
average, producing the same amount, or less, radiation. Alternatively, cargo inspection systems using the new design may opt to have the s
high-density, energetic ion deposition technique for depositing the active material, boron-10, onto the patterned silicon, which forms the
software system capable of assessing first responders health status during emergency operations. Real-time human health diagnostics and
re limited only by the three steps of 1) release from the surface, 2) transport to a collector/concentrator, and 3) collection efficiency for sm
WT). Its distinction from other peak detection methods is that it does not require any baseline removal or smoothing algorithms and is rob
dection in countering terrorism, and hazardous material identification in envioriemnt protection. IAI is well positioned to introduce this new
etworking technology, seamlessly integrating wireless sensors into existing plant infrastructures can enable wide monitoring and control ap
l collisions. One solution is to place temperature sensors along the length of the tunnel; these sensors can be used to detect blasts and issu

toring technology and meet its objective by developing a PCI card that combines coprocessor based firmware, reconfigurable computing an
proposed here will provide a high assurance attack detection and reconstitution capability that is based on hardware, but without the dep
 ble for road and portal management can make more informed decisions.

and-held or short-range and tethered to the launch platform. The law enforcement agencies would greatly benefit from a longer range (6 t
transportation are made more difficult by the transient nature of the passengers and the fact that passengers often carry a lot of luggage.
ets within a narrow field of view but these devices, if used alone, severely limit effective sweep width. Lynntech proposes an infrared imag
ed on piezoelectric technology for civil law enforcement officers and the military. The innovative new device would provide individual threa
tion this technology to commercialize use. The development of our Phase II prototype will not only leverage contextual knowledge obtained
iency exceeding 40%, depending on detector configuration. The use of annular ring design features eliminates neutron streaming and othe
o, individual technologies. As new techniques are developed, many of the same data processing challenges recur. In Phase I of this project,
available, portable gas detection product that can quickly and cost-effectively sense most hazardous gases. In this Phase I project, we will d
provide both neutron and gamma detection within a single unit. NOVA will team with St. Gobain Crystals for expertise in high speed scintill
tration of the feasibility of developing an improved chemiresistor sensor array with nanostructured sensing materials for the detection of s

o use the network. Our goal is to develop and market a practical product that will save lives.
While isotopic identification of shielded materials is now possible, accelerator portability and reasonable cost of ownership are lacking for c
Optics Corporation (POC) proposes to develop a new Dielectric Relaxation Analyzing Gauge (DRAG) that will replace isotope-based gauges f
stem. This noncontact system will agitate and sample air near the test object, and then condense vapor and particulate trace explosives on
this plastic sheeting is also used in food wrap, a sanitized tamper-evident version of NITSEW can be adopted by the food industry.
ction Spectroscopic Standoff System (ESD3S) based on integration of infrared (IR) structure resonance modulation spectroscopy (SRMS) and
f Remote Search and Rescue Seeker (HiProWSer). This proposed system is based on a high-repetition-rate, pulsed, eye-safe laser, and will o
ished technology, their radiological sources present on-going safety, security, regulation, and disposal concerns. A primary goal of this proj
he presence of dangerous arrhythmias, indicating increasing levels of risk of an immediate cardiovascular incident.
est. These sensitive materials will be selected from a broad class of linear, hyperbranched, and network materials. The relative response of
d against this threat. As part of the solution for DHS, Seahawk Biosystems is developing the handheld Talon Biosensor for rapid, lowcost mu
on techniques, there has been no paradigm or framework for quantitative comparison. This Phase I SBIR presents a unique opportunity to
to monitor and safely utilize radiation sources in legal manners. The local hardware, at the radiation source, will measure the radiation spe
dors
data
arewarehousing
based around into DMnet nodes.
nanoporous These
anodic nodes will
aluminum be and
oxide, distributed throughoutusing
will be fabricated a network and will of
a combination work togetherand
gas-phase in asolution-based
trusted grid todep
pro
ction and other fissile-material detection applications. The low power requirements will also enable wireless neutron detectors for contain
l functions and disturbing their real-time nature. The proposed effort will also establish metrics to guide events to log in a control systems n
and government control system functions. However, along with increasing popularity of this standard comes new risks in terms of cyber se
portable test instrument on construction sites where is susceptible to being lost, stolen or damaged. According to the NRC, there are about
ant technologies. PDA based architectures have provided a means for quick development of biometric field devices, but they also significan
n system integrates wireless communication abilities for real-time monitoring of tampering or damage to cargo at any time during the shipp
work, or in planned devices such as the Intelligent Personal Radiation Locator. Furthermore other conveyances such as passenger and cargo
itecture developed at UCLA. A router enables Peer-to-Peer communications with other teammates for emergency assistance, or for reach-
eines short-range,
number low-bandwidth
of sensors wireless
required to police networking
a given with
zone and energy-efficient
to extract routing
signatures protocols.
of removal We will
or misuse uniquely
activity givenintegrate
the lowertwo wireless netw
sensitivities of c
or our proposed system. ZonTrak will apply its concurrent development and commercialization process to shorten the time to commercial p
sive materials. This sensor detects improvised explosive devices (IEDs), car bombs, and other weapons increasingly being used around the w
tamper indication. This will be accomplished by impregnating the wrapping material with liquid tagging agents. These agents will remain c
shortcomings. Specifically, biological tissue fixation and methods used to mount the tissue to the supporting stent of bioprostheses cause
n that is currently dependent upon ot

are reasonably priced and easy to maintain. Such imagers will benefit public health by improving laboratory animal research. Unlike other s
the past decade. An estimated 30% of new entrants to homebound care are at risk for developing pressure ulcers. Yet it has been forcefully

covery during drug and vaccine development. There is strong interest in extending this microarray capability to more RNA-limited material
ort and provide a variety of positions to ease dressing, propulsion, and seated comfort. The backrest will improve user comfort, function, an
 mely important for drug discovery. The resulting field of Cheminformatics has blossomed in recent years and has been a hotbed for the ap
a from a variety of other sources including Social Security Administration records containing the detailed earnings history of the responden
ransducer arrays having thousands of array elements has been significantly limited due to manufacturing inefficiencies, transducer element
form involves apoptotic changes in the photoreceptor cells or the retinal pigment epithelium (RPE) cells underlying the central retina (mac
over time, is challenging (US CDC, 2003). Successful development and commercialization of next-generation, low-cost, high-performance te
lized in the cochlear prostheses development. In contemporary cochlear implants, however, the injected electric current is spread widely a
cumen LLC with earlier support from NIA. The purpose of MedRIC is to facilitate the acquisition and linking of administrative data from the
cumen LLC with earlier support from NIA. The purpose of MedRIC is to facilitate the acquisition and linking of administrative data from the
g, cancer diagnostics, and to vaccine discovery. However, in comparison with DNA and protein functionalized nanoparticles, the developme
rbohydrates in biological processes. Carbohydrate microarray technologies represent a new development at the frontier of glycomics. Micr

mponent in these systems that contributes grasp functionality, called a prehensor or terminal device, must strike a balance between functi
TTR to investigate proprietary novel, potent, selective and bioavailable A2AR blockers for the treatment of cocaine addiction. It is collabora
cells for transplantation, and 2) marked improvement in yields and viability of islets recovered using this approach as compared to the exis
eloped at Innovative Biologics, Inc. It is based on the blocking of the target pore with molecules having the same symmetry as the pore itse
cy, rehabilitation and ability to function at work and in normal daily activities. The methods currently available for neurocognitive investigati
disorder. Dentists are increasingly involved with the treatment of OSA with oral appliances, an accepted treatment of OSA for patients with
vexing problems associated with dialysis therapy, occurring in approximately 25% of all dialysis treatments, affecting 75,000 patients and tw
umber of disease conditions for which therapies are becoming available. Lysosomal storage diseases alone number greater than 40. There
ectronics (AME) completed in June of 2005 a phase II NIMH SBIR developing sleep sensors with embedded wireless links. AME completed
rocedures, but this is often not the case for chronic problems that persist day after day, hour after hour. Since it is impractical for most peo
or longitudinal surveys of the elderly. The device will be capable of using new dry electrode technology that promises to greatly simplify the
ant pediatric patients. Following a critical illness, children require specialized care to facilitate recovery and rehabilitation that does not imp
herapy will be performed in patients with radicular symptoms and associated back pain while concurrently recording using infared (IR) ima
mind-body interventions. The proposed system will utilize a suite of miniature wearable motion sensors to characterize limb and torso motio
ch and clinical applications. The study of muscular activation patterns has been widely used for clinical purposes and has proven to be a us
ures. The proposed system will record the magnitude of magnetic field strength from sensors in three orthogonal axes. The time history of
width (DC to 7.5 kHz) channels or 256 clinical bandwidth channels in real time. It will be designed with modular amplifiers that allow either
t efficacy, particularly for patients with metastatic disease. Targeted cancer therapy is designed to treat only the cancer cells and minimize
ostics to better select patients likely to respond to targeted therapies, including Herceptin(r) and novel tyrosine kinase inhibitors. 20/20 wil
stage to be The
territories. cured by surgical
resulting or other procedures. When used in concert with radiographic imaging, a sensitive and specific blood test for
quantitati

se producer
is to developcells
a newprovide complementary
therapeutic to E1a and E1b viral function in the cell for disabled adenoviral vectors. The 293 cell line has been v

ncer gene therapy the use of adenoviral vectors to deliver HSV-tk (AdV-tk) has been one of the most widely studied and promising approach
sease (COPD). The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), carbonyl sulfide (OCS), and ethane (C2H6) in the
00 Americans die every year from asthma, even though most asthma death is preventable with proper treatment, and the rates are especi
y ended the incidence of locally-acquired malaria in the US, but resurgence remains a risk, so surveillance and research remain vital to US p
and tricyclic antidepressants, none of which achieve clinical significance greater than 50%. To address this problem of significant clinical ne
d impairs cognitive performance. Among its many financial and physical consequences: sinking job productivity and rising auto accident ra
s, circadian disturbances, and psychiatric disorders. Many medication side effects impair cognition, for example diazepam causing amnesia
healthy tissue. However, numerous obstacles stand in the way of this regenerative technology becoming reality. Perhaps the greatest obsta
ardiovascular surgery. These infections, which arise from the establishment of biofilms on device surfaces, not only necessitate new surgeri
has serious repercussion on health and quality of life. Because of bone loss caused by this disease, bone grafting is routinely necessary pri
use it provides the three essential elements for bone formation: osteoprogenitor cells, an osteoconductive matrix, and osteoinductive mole
all prevention, postural perturbation assessment and activity assessment. It is fully responsive to topic areas identified as high-priority by t
epsis on a relatively eas

ed. Tissue regeneration is also an emerging frontier. This proposed research, when completed, will make an important contribution to both
ed. Tissue regeneration is also an emerging frontier. This proposed research, when completed, will make an important contribution to both
urprisingly, this student apathy is increasing while the general public reads record numbers of popular science books and watches increasin
ntitative studies of the correlation is the lack of robust, reliable, and inexpensive devices to measure the personal exposure to pollutants. F
s in creating personal synthetic voices for use with ModelTalker. The overall system is intended to be of particular interest to Augmentative

andard of care in the treatment of pain. However, opioids produce a spectrum of adverse effects, including opioid-induced bowel dysfuncti
ess process management. Our viewpoint is supported by a recent Forrester Research study that identifies proprietary software as "one of t
surgery routinely uses silicone balloon-type tissue expanders or self-infating expanders. Balloon-type tissue expanders require multiple vis
s of common respiratory infections, including infuenza A, infuenza B, parainfuenza (types 1-3), human respiratory syncitial virus (RSV), ad
deaths annually. Several drugs are approved by the US Food and Drug Administration (FDA) for treating infuenza infections, but successful
tanding of basic CNS processes, disease states, pharmacological and toxicological properties of drugs. The information-dense analyses of th
ies for processing multiple samples with high speed and reproducibility. These plates have a standard size (86 x 128 mm) and are available
estimated to be $48.3 billion annually. A fast, easy, accurate and effective test for brain injury is required to identify head trauma and monit
standing dynamic biological phenomena and recovering phase information in X-ray crystallography. To make the most effective use of thes
ys, the probability of interaction of neutrons with matter does not depend on the atomic number but is rather irregular across the periodic
velop new imaging techniques to detect lesions with certainty in early stages so that they can be treated. Developing biomarkers, which w
consumer goods, ranging from electronics, household goods, to toys. In 1997, the Consumer Product Safety Commission reported identify
achieves high coincidence timing resolution and energy resolution. But single crystals of LSO are difficult and expensive to grow, reproducib
isotopes of carbon, nitrogen, oxygen and especially fuorine allows virtually any compound of biological interest to be labeled in trace amo
CT) shows promise as a cost-effective means for detecting and characterizing soft tissue structures, skeletal abnormalities, and tumors in li
ng techniques that provide an image of the three dimensional distribution of a radionuclide in any slice through an organ under study in th
ssion Tomography (PET) offers high sensitivity to a range of biological processes through the use of targeted radiolabeled probes. Unfortun
mining protein structure, however, it is not well suited for analyzing hydrogen atoms and water molecules. It has been shown that the ther
ting researchers with knowledge in text and databases. The first step is to stop looking for words (as a search engine does) in data but inste

ncy virus (HIV) antibody in body fuids. The conventional particle agglutination assays have serious drawbacks such as limited sensitivity, lon
es in patients at risk for Hemolytic Disease of the Newborn (HDN), (2) screening individuals who receive anti-D for prophylaxis of HDN, (3) q
iction. People drink in excess for a variety of reasons, and an approach that targets more of these reasons will have greater commercial suc
ormation without an associated risk of creating antibiotic resistant bacteria. The coating combines a novel protein resistant polymer with a
for detecting suspicious findings with its high sensitivity but its lower specificity (false positives) is well documented. With increased emph
get a-particle emitting radioisotopes to the nuclei of melanoma cells. The selective targeting of alpha-particle emitting radioisotopes for can
d pancreatic cancers. Another isotope, radium-223 is being used in clinical trials in treatment of skeletal metastases. There is no effective th
microarrays. Glycans, which are predominant surface components of immune cells and microorganisms, give rise to high levels of anti-glycan
autoimmune disease. Proteome-wide screening against sera from patients with particular autoimmune diseases can enable the discovery o
ti-retroviral therapy (HAART), they often develop multi-drug resistance associated with mutations in viral genes which cause problems for lo
testing, if instituted for a large segment of the population, could result in a dramatic reduction in the approximately 56,000 annual deaths c
ren, NF1 causes learning disabilities, coordination problems and benign tumors later in life that grow on nerve tissue. Currently more than
ical samples. Molecular diagnostics assays offer the potential for more sensitive, more accurate, and more objective clinical judgments. For
genous
ent leukemia (CML)
colonoscopies. In ourand myeloproliferative disorders (MPDs). We propose to develop a single tube multiplex assay which uses high fide
application,
United States.
ovement with Enhanced Sensation. In AMES, the patient assists the motion of the robotic device using biofeedback of voluntary joint torqu
asis for how GPCRs bind to their cognate agonists and antagonists to elicit function is limited by the lack of high resolution 3-D structural in
eminding listeners to perform hand hygiene. Preliminary results suggest that listeners, who include nurses, physicians, visitors and patients
oxide releasing technology. NORTECH delivers NO in a predictable and controllable manner, and without the possibility of forming carcino
d polarizing, with death as the outcome in a large percentage of cases. Given the lack of specific therapy, organ transplantation is the only c
 replacement therapy. Few, if any, of the currently practiced therapeutic strategies oppose the molecular and cellular programs of apoptosi
r, increasing demand for suitable donor lungs far exceeds the number of available organs, in part because the lung is exquisitely sensitive to
ognosis and lack effective therapies. Recent advances in tumor molecular biology have led to renewed interest and heightened optimism fo
tinal tract, and heart. Scleroderma affects approximately 400,000 persons in the United States every year and according to research studies
pain, loss of function and disability. Approximately 2.1 million people in the United States, or 1% of the population, have RA. It can affect a
atients currently affected by SCI in the United States has been estimated at 250-300,000. Currently patients with SCI face a life-long sentenc
osmoBot Robotics System as a therapy intervention for children diagnosed with cerebral palsy, brain injury, and stroke. Cerebral palsy is the
anaerobic microorganisms for cancer therapy. Target specificity appeared largely due to the anaerobic requirements met principally in necr
years have seen a tremendous increase in efforts to identify more effective therapies against HCV. These efforts have been greatly facilitated
cleavage, will be developed. The unique features of the system allow for the economical production of large quantities of simple linear pe
of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect
ation of keratinocyte proliferation and differentiation. This signaling module is centered on the enzyme phospholipase D2 (PLD2). PLD2 norm
refractory prostate cancer. Epidemiological studies have demonstrated a strong relationship between incidence of and mortality from vario
ical and mental development. Diagnosing and understanding these disorders are major challenges. Polysomnography, an imperfect gold st
ts critical role in sphingolipid metabolism, we have focused on SK as an innovative molecular target for the development of new drugs for t
he population worldwide. Although insulin therapy and islet transplantation are currently the most effective treatments, both of these app
lly deliver survivin, a tumor associated antigen (TAA) to professional antigen-presenting cells (APCs) and activate them for the generation o
ave been rather limited in clinical trial settings. Although the reason for clinical inefficacy for these vaccines is not known, the lack of an adj
of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research su
extinction polarization and quantitative birefringence imaging for digitally enhanced display of crystal bulk contrast (referred to herein as D
training tool will allow providers of moderate sedation access to a continuously available and comprehensive source of reference material
nments. Unexpected events occur frequently in the ICU and many are related to missing, inaccurate or misinterpreted information. In a on
ay that was based on a two drug interaction model, which was previously developed for an opioid (remifentanil) and a sedative hypnotic (pr
anical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile fow. The final product will be the fi
enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have succ
ocesses of procurement, preservation and restoring blood fow. This clinical condition, recently termed primary graft dysfunction, remains
g. Vector control programs currently utilize trapping technology that targets adult host seeking behaviour (CO2, octenol, lactic acid etc. bait
salt water environmental testing. In this proposal, we explain how we will develop and validate a large microarray (5,000+ genes) in sheep
rway obstruction. According to the American Cancer Society it is the single largest cause of cancer deaths in the United States (173,000 esti
posed medical treatment, but that it be presented in an understandable way so the patient can make meaningful choices about medica

otype. These efforts promise to pave the way to better prevention and treatment of human disease. Many laboratories maintain archives o
elevant pieces of information are scattered among thousands of scientific publications, and bringing them together is becoming a bottlenec
patients are particularly susceptible to chronic bacterial infections with >80% of CF patients becoming chronically infected by 18 years of l
replacement therapy (ERT). However, ERT is not effective for the brain, because the enzymes do not cross the brain capillary wall, which fo
e manipulated using magnetic force. They are manufactured on commercially available photolithographic equipment using efficient and ro
k on the force and torque applied during colonoscopy. The CFM is designed to improve the training of endoscopists, establish best practice
ommon cause of new blindness in young patients, and choroidal neovascularization (CNV) resulting from AMD is the chief cause of severe a

se to therapy using imaging include CT and PET scanning. Emerging methods include functional and molecular imaging. In addition to the u
r the alarm system is to provide continuous noninvasive measurements during the sleep period of an individual with diabetes, sounding an
ough biosample testing. The broad objective of this proposal is to develop an extremely sensitive and selective biosensor device capable o
Pre- clinical studies performed in a rat pup model of HI injury as part of the funded Phase I STTR grant, point to benefit when Multipotent
are and use of laboratory animals to reduce or preferably eliminate pain and distress by using analgesics, provided these analgesics do not

fically, this project aims to develop an assay to identify the presence of Mycobacterium ulcerans (MU) in environmental samples to determi
ost-often used earphones employ a supra-aural design that has several undesirable characteristics, including 1) an "occlusion effect", an arti
ococcus infections, has not only moved into the general community, but also grown to include a number of widespread and serious pathog
which can be implanted directly into the inner ear. The initial project will be to develop an inner ear delivery system for corticosteroids. Th
ble formulations for the drugs tacrolimus and cyclosporine. Substantial inter-and intra-patient variability means that even frequent drug mo
ment of Parkinson's Disease (PD). The immediate goal of this project is to develop an injectable sustained release formulation for the recent
racellular matrix proteins in lung parenchyma. Globally, five million people are affected by pulmonary fibrosis. In the U.S. alone, 200,000 su
s complicated by lack of effective methods for early and accurate diagnosis of the disease. Thus, there is a significant unmet need for Alzhe
slowed by a lack of reliable methods to measure BCM in vivo. The ability to accurately track BCM would facilitate development and clinical
o move muscles or to feel normal sensations. To treat these problems, more than one million procedures were performed in the US in 2002
the prevention of axonal degeneration and peripheral neuropathy. Axonal degeneration (or degeneration of axons) is a common pathologic
apeutic properties. We believe that we can achieve this goal by altering both the tissue-binding and proinfammatory properties of BCG. Th
an infict profound and persistent impairment of physical, cognitive, and psychosocial functioning. The physical, social and economic seque
course of a patient's treatment. The approach is intended to be a supplement to existing methods for assessing patient functioning, which
number of preterm (< 37 weeks postmenstrual age) very low birth weight (< 1,500 g) infants born is growing [2]. Of the approximately 50,00
ess,
wellinterference, and
for all types of dibeliefs dimensions) that offers improved accuracy and efficiency over conventional approaches. The KnowPain asses
he human motor system.
es (F-spores)
monitor produced
and control theat BCR appear
spread and to be physiologically identical to normal spores except for performing as self-reporters of initial
commercial poultry operations.
ying medically important pathogens. Unfortunately, these databases are growing at an exponential rate, posing a severe problem for bio-se
's Check-up (CDCU). The CDCU will be a revision of the Drinker's Check-up (DCU), a Windows program and a web application developed for
ognitive-behavioral change protocol of SMART Recovery (www.smartrecovery.org). The goal of OA is to help users learn cognitive and beha
proposed research is to develop a stress assessment inventory for Hispanic adolescents. This Phase II study builds upon the results of the P
of Behavioral Activation, a therapy for depression (BA). The current application represents a cooperative partnership between the PI, who
atment for Adolescents (PCT-A). The current application represents a cooperative partnership between the PI's small business concern, Beh
evers, antidepressants and anti-psychotics, as well drugs used for neurodegenerative diseases such as Parkinson's disease and Alzheimer's
nfammation plays a contributory role, such as atherosclerosis. Chemotaxis - the movement of cells aligned with a chemical gradient - is the
architecture and cellular microenvironments into an assay format that is compatible with the high throughput approaches used for early dr
e been difficult to ascertain partly due to the lack of stage specific in vitro cell assays. Recently, we have developed a murine in vitro pancre
o develop cancer treatments via the Small Business Innovation Research funding mechanism. The long-term objective of Bexion Pharmace

rated by progressive resistance training (PRT). During traditional PRT with weights, the agonist (target) muscles lift a weight with a shorten
ase". Our goal is to improve the probability of a laboratory discovery that impacts human health by providing a better research tool for stud

on is of particular importance when designing new hydrogenation catalysts. For example, the chemo-selective reduction of C=C bonds that
ting sensor over the skin without making contact with it and plots the surface potential distribution over a 1 cm distance in about 1 minute
eds in MRI-based breast cancer interventions by integrating real-time magnetic resonance imaging and precision placement/monitoring of
rated data produced by today's technologies prevents scientists from effectively reducing these data to meaningful discoveries. As a result,
e sufficiently localized tumors to allow for surgical resection of the tumor. Cancers over expressing the epidermal growth factor receptor (E
hardson at Harvard Medical School. This pWGA system utilizes multiple replication proteins including a primase/helicase, a DNA polymeras
ietary concepts enables ultrafiltration to be practiced at low pressure, and without the need of centrifuges or other complex apparatus, re
t to study because, for a wide range of reasons, they are difficult to culture. Phenotype MicroArrayTM (PM) technology is a tool that can ai
become life threatening if not detected at an early stage. Current methods for diagnosing pneumothorax (chest x-ray, chest CT scan) are no
us fuids administered at the incident scene to treat hypovolemic shock do not completely prevent ischemia and reperfusion injury. Re- initi
more lives than any other measure. Tissue adhesives and sealants have been developed to control bleeding; but, currently, all existing hae
on using space-time datasets. Despite the increased use of Geographic Information Systems (GIS) in exposure assessment research, spatio-
-level health data, providing: description of spatial patterns of cancer incidence and mortality rates and identification of scales of variability
 histories, risk factors, covariates and cancer induction and latency periods. To date, two of the major deficiencies of geographic studies of c
onal Glaucoma Drainage Device (GDD) and surgically implanted under the sclera for the purpose of continuous measurement and transmis
ncer. The long-term goal of this project is to develop a fully integrated chip and reader capable of single molecule analysis of large native s
orldwide for antigen detection and purification in basic research as well as the detection of disease states. Increased availability of quality a
se in the United States and Europe and as such it is a significant public health concern. The disease affects multiple organ systems including
ow geographically. The enzootic cycle of this pathogen requires that Ixodes spp. acquire B. burgdorferi from infected wildlife reservoirs and
a result, the number of patients with end-stage renal disease (ESRD) is expected to double between 1999 and 2010. These increases in CK
measure the efficacy of delivery systems, bio-distribution and effective dose. In Vivo Survey Technology" (IVST) is a label material designed t
, especially arterial occlusive disease, is x-ray angiography, an invasive, costly, and potentially hazardous procedure. In the United States alo
and genetic defects of these cytokines are known to be involved in various immune diseases. Adversary effects of increased TNF expression
e units around the world but therapeutic interventions have been largely unsuccessful. Clearly, there is a great need for inventing efficaciou
CAS-OCT) scanner for use in clinical and applied research applications. OCT is a relatively new technology for ophthalmic imaging, which us
ve, rugged and easy-to- use diagnostic able to measure viral load with rapid time-to-result would revolutionize HIV monitoring and infant di
cement or deletion of unwanted or unneeded host DNA. Our initial studies will concentrate on developing the technology for the rapid me
specific signaling pathways. Efficient reporter genes encode enzymes that act on pro- fuorescent and pro-chemiluminescent substrates to
allowing the subject to move freely within 10 m of a receiver. DT digitizes neural signals at the electrode connector to avoid inductive nois
ese individuals can communicate. While many voice enabled AAC devices are currently available, they lack the important ability to generate
approximately 2 billion dollars/year to the US healthcare system. IBDs are of unknown cause, have no cure and are increasing in incidence.
ware to compute power for meta-anal

disease. Additionally, African Americans experience significantly more premature morbidity and mortality compared to white Americans. Tr
nt, antibiotics, mucokinetics, peptides, anticancer agents, and biologics. Whereas there are excellent nebulizers for the delivery of microgra
or 26 percent of total global mortality and are the third leading cause of death in the United States. In addition to microbial identification f
million in the United States. In the U.S. this disorder, along with its associated complications, is ranked as the seventh leading cause of dea
mmune diseases and diabetes. To date, apoptosis research highly desires cell permeable and sensitive caspase substrates for detecting casp
s is possible because the automated systems can perform assays in parallel using16 and 384-well plates. While the drug discovery industry
and faces to aid in everyday tasks such as travel, navigation and social interactions. The practical, cosmetically acceptable packaging will co
tal shoulder arthroplasty or "TSA", is often the only effective treatment for the severe, unrelenting pain that affects these patients. TSA is a
atment of chronic granulomatous disease and severe malignant osteopetrosis. Other indications currently being investigated in human clini
opment of a new vascular network within the synovium that allows for the delivery of cells and nutrients to the invading pannus. This form
imited retinal imaging through dilated pupils in at least 90% of the human population. Electrostatic actuator design and manufacturing pro
infammatory and coagulation pathways and therefore predispose to PE. These conditions include surgery, cancer, age >70 years, prolonge
orted annually in this country, about half are associated with catheters, ureteral stents, central lines and other percutaneous devices that pr
co-reside with over 400 other non-harmful/commensal microbial species in the Dental plaque. The current anti-microbial strategies used to

nteractions, protein-protein interactions, and post-translational modifications. We propose to create a new proteomics technology involvin
response to environmental stressors (BRES). Caldera developed RPM in collaboration with Los Alamos National Laboratory. RPM allows th
ens in NCCAM clinical trials. Caldera will use their high-throughput proteomics technology to identify CAM Adherence Biomarkers (CABs) u
0 patients, in part due to the low median survival of 3 to 5 years post diagnosis. Riluzole is the sole drug currently approved for the treatme
the
te most
time frequently
consuming mutated genes
tomographic in patients with early-onset familial parkinsonism, and a number of findings from our studies and othe
reconstru
r better targeted trials and in the m

th resulting cost to the medical system exceeding $1 billion dollars annually. In the pediatric realm, it is estimated that over 2,000,000 deat

e project will accelerate the development and commercialization of human heart-derived cardiac progenitor cells (CPCs), to promote more
rticle system for the targeted delivery of therapeutic compounds and (2) use this technology to improve doxorubicin safety and efficacy in n
h only measures arterial oxygen saturation (SaO2), cerebral oximetry measures parameters that mostly refect regional metabolism and the
evention programs with adequate training aids to support their effective delivery and implementation. The Brief Alcohol Screening and Int
oglial activation states have all been shown to reduce Alzheimer disease (AD)-like pathology, and cognitive deficits in AD transgenic mouse
ransplant means that less than 1% of the insulin-dependent diabetes (IDDM) population could be treated with this protocol. The ultimate o
erstanding and manipulating the cell survival and cell death pathways activated in response to various stressors. Recently, we have recogni
f the cell therapy and cancer arenas. In the former, CPSI studies stress pathways activated during hypothermic storage (4C) and cryopreserv
f the cell therapy and cancer arenas. In the former, CPSI studies stress pathways activated during hypothermic storage (4C) and cryopreserv
eomics, it is still difficult to find lysine acetylation sites in proteins. Although IMAC can be used to isolate phosphorylated peptides in bulk, t

ent as well as during oncogenesis. PhosphoSite is a bioinformatics resource that systematically has collected information from thousands o
nology industry. This will focus on predictive hepatotoxicity screening, which has been included as one of the Critical Path Initiatives by the
of this information into a rational drug discovery process. Unfortunately, this is at present challenging, primarily due to the limited choice o
of this information into an operational cell-based model. Unfortunately, this is at present challenging, primarily due to the absence of suita
of this information into an operational cell-based model. Unfortunately, this is at present challenging, primarily due to the absence of relia
tion (XRT) remains an important therapeutic modality in the treatment of malignancies. Injury to the gastrointestinal tract (GI) and hemato
o isolate and concentrate fu virus from a large volume sample. One application for the solid support coupled with this polymer is its use fo
HAART) which has dramatically improved the outlook of HIV/AIDS patients is expensive although it is gradually being made available to deve
condition has led to increased focus on cardiac toxicity in drug development. The FDA now requires cardiac safety studies prior to drug app
tic amount of 51 million prescription errors per year with about 3 billion prescriptions being filled. There are as many as 7,000 deaths repor
hanced Raman scattering (SERS), these two components can be synergized to create a highly multiplexed, handheld, diagnostic immunoas
ualization of dynamic biological processes such as heart motion, it is necessary to establish scanning as a purely electronic process. Two dim
ignificant impact in diagnosis and treatment of these conditions. It has been used in lesion visualization, stent placement and stent monito
l sugar attached at C6 of the macrolide) were the first macrolides to display notable antiviral and antiparasitic activities. These new activitie
reat non-small cell lung cancer. These and other findings underlie our belief that a cancer drug could be developed from such natural produ
this time, procurement of donor pancreases for islet isolation and transplantation is in its infancy. Most pancreases at more remote donor
es a monolayer of whole blood and uses computer image analysis. The system will be compact and much less expensive than current CBC in
re in various ways with hormones such as estrogens to have significant adverse effects on many behavioral and physiological processes. ED
cularization (NV) is one of the major pathological changes in DR. Retinal NV can ultimately result in severe vitreous cavity hemorrhage and
the two major pathological alternations leading to vision loss in patients with DR. Over-expression of vascular endothelial growth factor (V
le greatest cause of vision loss in diabetic patients. Currently, there is no effective drug treatment for DME. Although the pathogenesis of D
nfected wild or domestic animals. Leptospirosis is recognized as an emerging infectious disease in the US, where it has caused extensive ou
tients. Recent genomic advancements in oncology have established the ability to perform gene expression profiling of cancers, which can gu
ursor for the synthesis of fatty acids but it also regulates fatty acid oxidation in mitochondria. There are two ACC isozymes in humans, with
water. The serious toxicity of arsenic has been well documented. Worldwide, communities demand novel separation technologies for the r
ng several billions of dollars a year, for the care of high-risk pregnant mothers, and the short- and long-term care of the prematurely deliver
tive healthcare delivery. TEACH will serve patients from the African-American (and later other ethnic) communities confronting malignancy
of infection, infammation, asthma, autoimmune disease, and neoplasia. This system will be a microarray-based bioassay platform that spe
. Traditionally, radiography has been used to measure RA progression. In vitro diagnostic tests for RA and related diseases consist almost ex
focus of intervention for T1D is on the detection and characterization of autoreactive T cells, which play a central role in the attack on insu

mergency situations and reduce time needed for hookup and clean up of each patient. The new electrode is based on a simple idea but req
he clinical system will aid in early screening by objectively quantifying several key PD symptoms including motor features, sense of smell, sle
hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense. Since the BBB selectively (by specific transport m
ne
entwith dementia
to patients has
with been well
alcohol use ddocumented; caregivers' physical and mental health often declines as they struggle to care for their loved o
uth mental health issues account for 1.6% - 5.0% of all ED visits, and that Emergency Medicine physicians are the first to interact with these
deficits, including impaired memory function, are strongly linked to the long- term disabilities found in patients with schizophrenia. Amelior
D) and related disorders. Fibrillar Aa deposition in the cerebral vasculature, a condition known as cerebral amyloid angiopathy (CAA), is also
matory outcomes in clinically relevant paradigms of colitis. Specifically, we will employ the acute Citrobacter rodentium (C. rodentium) mod
e is characterized by tremors in the limbs, bradykinesia, akinesia, rigid limbs, and a shuffling gait. The symptoms of PD are caused by the de
infammatory response and activation of the blood clotting cascade. Efforts to develop effective therapeutics to treat sepsis have been disa
d. More than half of MS patients do not respond well to the current FDA-approved disease-modifying treatments. This lack of response ma
ressive forms of MS (PP-MS) and more than half of Relapsing Remitting forms of MS (RR-MS) fail to respond to existing therapies generatin
surgical procedures. Fixation of small bones (i.e., distal radial fractures) is complicated by the difficulty in using screws and pins, and comp
novel adhesive will reduce fuid accumulation after surgery by eliminating dead space in the wound and maintaining tissues in position for
ne. Under optimal circumstances, production of enough vaccine to protect the US population would take 6 months. A lag time of 6 months
etween a learner's native language and English negatively impacts their ability to understand fuent speech and therefore reduces their edu

n when
able, evaluating results
reproducible isopropyl alcohol
from sampl(IPA)-Water separation. Membrane stability, which had been concern of reviewers, was shown to be e

e disposal in the tissues may be beneficial for diabetic patients to control the blood glucose level in the postprandial state. We have recentl
resenting this genomic data to drug

re exist no protocols and instruments that are practical for clinical use on a daily basis to assess the benefit of cochlear implants (CIs). The
eless or by internet a "Personal Exposure Monitor" for the detection of trace amounts of harmful chemical species present in the exhaled b
03) and is a major source of disability, accounting for upwards of 700 million lost work days and $100 billion in health care costs per year (R
ble. The effort builds upon a previously developed efficient Poisson-Boltzmann solver and extends it to tackle the computationally more de
nd demonstrate the unique properties of a laser cured collagen adhesive to repair ophthalmic tissue with superior strength and stability. M
ualitative inspection of the palpebral conjunctiva has been shown to be inaccurate in diagnosing anemia, the palpebral conjunctiva is an ex
xcision
ost andmaymadebebroadly
combined with radiotherapy,
available to mam which compromises the vascularity of the remaining tissues. Benign tumors of the mandible m
and false negatives and saving lives.
y listed in PA-04-064 to "develop new products that improve data collection, data analysis, and data dissemination of gerontological researc
g independently, transfer from a wheelchair into and out of a bathtub. LifterMate is an assistive transfer device that will help clients and car
created by market changes where patients are increasingly being made aware of differences in quality between providers and pay higher p
ffected
tal kneelimbs. One relatively
arthroplasty new and promising device that may address these aims is the NuStep TRS4000 recumbent cross trainer, which
(TKA). Qu

that provides realtime, point-of-care measurement of methemoglobin fraction in patients. High fractions of methemoglobin lead to tissue

support
ized recombinant therapeutic
and under-treated. The proposprotein manufacturing. There is a current and projected shortage of worldwide GMP manufacturing cap

e life span makes this treatment unacceptable for younger or active individuals who often require progressively complicated revision surger
or assessing cell mediated cytotoxicity against human tumor cells, which is a critical component of tumor immune therapy. We specifically
us between mouse, rat and human. Recently, we found abundant expression of CYP4X1 in the dorsal root ganglia (DRG). We have identified
, peripheral limb ischemia, and to effect local and systemic repair of atherosclerotic vessels However, as with many forms of cell therapy, o
dentification of means for intervention at the molecular level are of paramount importance. Modern nuclear magnetic resonance (NMR) sp
ort training materials for use in special education or advocacy settings for individuals with Asperger Syndrome and/or High-Functioning Auti
onal curriculum for adult substance abusers, facilitated by counselors and other treatment professionals in diverse treatment settings. The
an increasing sense of tension immediately prior to pulling hair out or when attempting to resist the behavior; pleasure, gratification, or re
mprehensive training resource for mental health professionals to help them engage and retain underserved children and their families in tre

mprehensive psychoeducational program for counselors to use with adolescents ages 13 to 18 with problems related to alcohol or other su
mporal studies to investigate some health outcomes. Typically, the interest focuses on the impact of some treatment intervention. Such data

fants, young children or adolescents. With cutting-edge research spurring medical advances, each decade has shown improved survival, fr
ng of the person with BPD, are a few of many difficult issues for family members. The Living with Borderline Personality Disorder education
adolescents in grades 7 and 8 about the health risks associated with the consumption of alcohol and provide them with information to mak
. These CPT analogs are lactones that have increased activity in acidic hypoxia tissues, characteristic of fast growing cancers that characteri

s and assisted living facilities as well as informal (family) caregivers providing care in the home, using DVD/Web DVD technology. AIMS: Tra
onomy. Tremendous changes are occurring in the patterns of urbanization, migration, and regional development. Great challenges and opp
method for regenerating lost bone and tooth support resulting from periodontal disease.2-6 MIS utilizes much smaller incisions than tradi
alf of DUI arrests and alcohol-related crashes originate. These programs train licensed sellers and servers of alcohol regarding the medical a
partial syndrome eating disorders are among the most prevalent mental health issues affecting adolescent girls and young women. Twenty
lly available and inexpensive replacement drug, we have developed a novel class of molecules called "reversed chloroquines" (RCQs) which
oject ("Neighborhood Estimates of Expected Demand - Planning and Utilization System") uses data from the National Health and Retireme
d States and Europe, and as a pre- and post-donation screening test in blood banks in developing countries especially those that process le
abetes is now projected which will have serious healthcare and economic consequences. The discovery of new biomarkers will be very imp
DCP), is designed to circumvent serious limitations in the current capabilities of current proteomics technology, notably DCP can identify th
ltiple chronic conditions. Phase I of this project will involve running a feasibility study to determine whether the system can engage a user
ents suffering from major depression. The ultimate objective of this SBIR is to automate the assessment of depression and deliver that auto
ovel therapeutics to treat cancer, autoimmune disorders, diabetes, and brain diseases. In this grant, we propose to develop a novel techno
in regulating cellular functions and the diseases caused by their disregulation, much interest exists in the pharmaceutical industry to devel
apeutic purposes. Here we propose to develop a method for improved targeting of the SB system to specific cell types following systemic in
one marrow failure early in life. FA can be effectively treated by allogeneic hematopoietic stem cell transplant. However, most patients lack

ry for compensation for hearing loss as a primary disability only is currently over $630 million per year. The non-monetary costs, in terms o
ories. Lymphatic filariasis (caused by Wuchereria and Brugia species) creates an enormous health and economic burden within affected are
this optical system is to enable ultra-rapid and accurate imaging of tissue, frozen-tissue, tissue-microarray (TMA), and cytology glass slides
must be both highly sensitive and simultaneously produce a low false positive rate. To meet this stringent requirement, probes and prime
that radiation dose be applied to target sites in the body, while sparing adjacent, healthy tissue. To accomplish this, therapists make use of
n pre-clinical studies in small animals at high-fields. Substantial gains in S/N appear likely for a wide range of pre-clinical, single- organ, MRS
on the insoluble proteins that are critical to bio- logical function. Various recent developments have enhanced the effectiveness of solids N
aim in phase I is directed towards developing viable prototypes to upgrade current experimental methodologies. Proposed devices used fo
high resolution, and low detector cost. It can be incorporated into existing Dental radiography equipment, replacing film-based or scintillato
combined with CMOS
ng. This project readout
will create newarrays. This new technology will deliver significant improvements in diagnostic capabilities. We will develop a
cell trac

thods are urgently needed to identify people with impaired autoregulation who may be at increased risk for stroke and adverse outcomes.
DNA libraries for novel and useful antibiotics and consists of the following Specific Aims: (1) To further modify both the E. coli strains engin
Ultraprecision diamond machining such as diamond turning and milling has been widely used to produce optical-quality surfaces, ultra- p
arch settings. Thus, body composition analysis (BCA) results can be used to monitor and evaluate infant growth patterns, efficacy of nutritio
he problem is an inability of the clinician to accurately detect localized infection by clinical observation, which is still the primary diagnostic

ortant agricultural and national security concern. For example, thousands of people are sickened annually by mycotoxicoses related to crop
35 to 45% of adults in the US have chronic periodontitis, with up to 90% having some form of periodontal disease. In addition to pain, disco
ts anti-microbial (including anti-HIV), wound healing and anti-infammatory (including anti- arthritis) activities. SLPI protein is found natura
uble correctly folded functional protein products. Unfortunately, a large amount of the protein expression systems that are commonly used
o students with high incidence disabilities (HID). To evaluate the feasibility of this type of instruction software programs will be designed to
nded lipid bilayer configuration that simple electronic models and calculations show offers a factor of ten sensitivity improvement in meas
diseases are being recognized that arise from channel malfunction. In addition, the adverse side effects of some drugs on ion channels ha
of products for middle school life science specifically tailored for this segment of the student population. EDVOTEK, the applicant organiza
oupled to a battery operated reader, is a direct need for the NIH Exposure Biology Program and has the potential for detect other exposure
oys nanotubes with molecular sized openings embedded within a mechanical and chemically robust polymeric membrane. We propose tha

d(DTPA). The commercial embodiment of this method will be a software package that will convert a set of 2D cardiac MRI images to a 3D m
ith autism. The proposed archiving system will permit educators to record only those data or behaviors judged to be important for later ret
aureus (MRSA). The starting materials are natural product mixtures produced by hit clones previously identified in eMetagen Corporation's
US, is growing along with the global growth in chronic kidney disease (CKD) patients, the general health of the dialysis population is declin
ferring research-based findings to practice in substance abuse prevention and related fields. There is widespread consensus that it is impor
data-based decision systems that are feasible and useful for local planning, intervention design, and resource allocation. Although states, co
e sounds to others, thereby establishing themselves as people with distinct personalities as perceived through their speech, in the manner
rgery means increased cancer recurrence, patient anxiety, complications, and cost. Currently, surgeons have no readily available, cost efficie
ation, as a recently emerged class of therapy for treating AVMs, generally involves catheter infusion and subsequent precipitation of an org
year in the U.S. It is estimated that an equal number of unruptured aneurysms, usually discovered incidentally, are also treated. Endovascu
mpler sampleApreparation
and market Compact Soft than is required for electron microscopy. In addition, the lower radiation dose required (compared to electron m
X-Ray

processing and detection platform customized to perform a broad range of assays, coupled to automated data recording and/or transmittin
provide a newdesigned
is specifically avenue totolaboratory-quality
protect arsenic detection and quantification in a field-portable device at reasonable cost. The long term
phosphate pesticides. Cost-effective

abuse on the brain. The exhibit will feature detailed, 3-D graphical models of the brain, animated to depict its activity as it functions natura
murine Rh homologue, and that these specificities would be produced by mice whose repertoires are shaped in the presence of human Rh

anical ventilators are used increasingly for life support in patients with serious respiratory illness. Traditional pulmonary function tests (spir
, production of antibody and production of therapeutic proteins. The rabbit is large enough to provide adequate quantities of tissue for exp
ce owing to the high rates of reocclusion of cardiac arteries observed following initially successful fibrinolytic therapy with t-PA or streptoki
ing detection and propagation of rare favorable cells. The technology was applied to murine splenocytes and hybridomas, achieving a spec
polymeric delivery system (PPC) formulated with the Interleukin-12 (IL-12) gene and lyophilized to produce highly concentrated nanopolypl
to-immune, infammatory, hormonal, neurogenic, and iatrogenic components. Common to all etiologies is a decrease of both volume and q
respective ratios are significantly changed in the cancerous state. However, one of the major obstacles in elucidating the significance of ca
environments, where the infection rates are highest. Cost of obtaining an accurate CD4+ count is not the only barrier to routine CD4+ moni
eactivation of latent TB. This epitope-driven, DNA-prime, protein-boost TB vaccine has been in development since 1997, when our immuno
han 50% of severe hemophiliacs produce antibodies (inhibitors) in response to treatment. Immunogenicity to Factor VIII (FVIII) is its most s
s clearly demonstrate that by modifying the drift gas with chiral molecules, ion mobility spectrometry can provide a novel and rapid separati
in breath relies on decades old technology and may limit development of breath analysis to detect not only ethanol with great specificity, b
MAMS) which will meet the criteria of the solicitation from the National Institute of Mental Health (NIMH) for "Development of information
when macrophages are subjected to lipid-rich environments which lead to their transformation into lipid-rich foam cells that can form arte
herapeutics for diseases from cancer and infammation to diabetes. Determining efficacy and specificity of the novel compounds in cell-bas
omia and Romberg's progressive facial hemiatrophy), traumatic defects (e.g. avulsions, complex wounds) and cancer-related defects (e.g. m
evaluation in 12 patients with bre

fundamental observations: [1] FAS is highly expressed in most common human cancers, and [2] pharmacological inhibition of FAS leads to
anisms by harnessing the power of in vitro transposition mutagenesis. The industrial microorganisms of interest to this study are the actino
metabolic node has become a focal point for strain improvement strategies. The main goals of this study are to identify key enzymes and m
gical damage. Current diagnostic tests for severe neonatal hyperbilirubinemia do not correlate well with bilirubin encephalopathy in newbo
wound healing. Approximately 20 percent of patients with diabetes will develop foot ulceration in their lifetime. Diabetic foot ulceration (DF
e under conditions of dynamic equilibrium. This chemistry incorporates element that allows the template-created primer to primes the syn
the advent of the internal combustion engine has substantially increased the concentration of PM, particularly in urban areas. Human deri

etting. In Phase I, the hypothesis is that speech translation technology that has been developed for the U.S. military can be adapted for use
urgently needed to compare engineered tissues, particularly cartilage and other soft tissues, with normal tissue. Histology is slow, cumbers
TI) proprietary techniques - fuorous tagging and automated fuorous solid phase extraction, and for (2) direct arraying of fuorous-tagged c
mpounds into a cell - without permanent damage to the cell - is a pervasive challenge in basic cell biology research as well as in drug disco
e/ethnicity and SES. School success is a vital protective factor against health risk behaviors in adolescence. Addressing threats to school suc
e (IOP) is the most common risk factor. Results from large clinical trials indicate that decreasing IOP in glaucoma patients delays the develop
n viral targets. Unfortunately, given the rapid generation of viral resistance, there have been many failures employing this strategy. It is imp
e mission to be the first industrial group to design, prototype, test, and manufacture new "miniature" preamplifiers in RoHS compliance fo
onadism the potential benefit of increasing bone mineral density, inducing greater muscle mass and strength, enhancing sexual function, an
roposal of 1 year's length is to identify a potential antidepressant with a novel mechanism of action. This novel mechanism of action is the
 includes assessing the impact of attacks and predicting future adversary intentions. The product of the proposed program is an environme
object inside undetectable by active sonar. Like all technologies, AMM will require considerable effort before it becomes a practical reality
d trajectory. Such a sensor would obviously provide valuable information to be used for fuzing and for assessing whether or not the weapo
devices incorporating single crystal piezoelectric materials. The technology for the simulation used in the Toolkits will be based on PZFlex,
ation, droplet size, and quantity. These new fuel injectors would meet all the needs of the PDEs, allowing for effective continued developm
c RSFQ-based sub-system to form a complete signal identification and discovery capability. The RSFQ components digitize a wideband RF in
he possibility of additional impulsive loading from primary debris. We propose to generate a fast running model capable of predicting dam
aptive signal processing to mitigate received signal distortion arising from frequency-selective fading; 3) adaptive signal processing to suppr
2 and layer-3 multicast groups, as well as re-keying unicast keys. The design utilizes network infrastructure that will be common in future a
laser peening, are proposed. The purpose is to selectively use certain treatments to enhance scuffing and fatigue in the precise areas whe
n of platform-induced (e.g. an Autonomous Underwater Vehicle, SEAL Delivery Vehicle, or diver) bioluminescence based on local environme
ter this data using inexpensive wi-fi technology. An extended version, the SWAN-M drifter, will also be equipped with a 17-angle volume sc
s, all of which are within the communication range of at least one other node. The Accu-MiSTS solution incorporates a modular approach t
ch topological changes. Establishment of reliable routes between multiple MANET networks becomes a challenging problem that the tradi
hen they are difficult and expensive to fix and likely to result in significant program perturbations. Potential safety issues that were not for
mine both radial and circumferential temperature variations. Thin film passive wireless sensors will be arrayed with other like temperature s
ents). Compared to analog beamforming methods, a DBF offers significant improvement for satellite tracking, aperture resource managem
provements will be used in Phase II full scale testing.
of advanced malicious code. In many cases these exploits already exist and go undetected in already infective hosts, are opportunistically
osed development effort will focus on experimentally demonstrating the highly operable, highly reusable, and highly reliable features alrea
in aircraft. These advances will make fire suppression feasible even for small aircraft such as UAVs. We will use commercial-off-the-shelf IE
fexibility in radios, Williams-Pyro has designed a highly innovative software-defined radio system. We propose to optimize our existing so
cations, surveillance and reconnaissance systems, weapons systems, computers, and other battlefield support equipment. In order to mini
to coordinate the actions of the independent sensors. The manpower needed to monitor these systems is exorbitant, requiring expensive

ed techniques employing state-of-the-art (SOTA) components. RF performance will be modeled and predicted over broadband and narrow
sition, storage and playback. Scalability is emphasized throughout the design to ensure that subsequent components derived from technol
nopropellants. The proposed propulsion system uses self-pressurizing nitrous oxide and ethane with specific impulse approximately 265 sec
ensity, and a greater range of storage temperatures. What is innovative about this approach is the combination of using desensitized nitro
could be as high as 10% to 15% of rated power. For the case of liquid cooled machinery in modern tactical aircraft, heat input at these lev
d of two tools, a Core Framework (CF) Analysis Tool and a SDR Diagnostic Tool. The purpose of the CF Analysis Tool is to assist SDR wavefo
and vehicle design features into XCOR's Minimal Supersonic Vehicle (MSV). XCOR Aerospace proposes a partnership to enable reliable, rap
gh resolution stereo display. With head tracking and registration, it enables wearers to view a 360 º immersive virtual environment and mu
he state of the art beyond devising formal processes and practices but will enable application of these concepts to specific implementation
ns. A need exists to provide representations of diverse, yet coordinated, behaviors affecting MILS policies and certification as executable m
in each development spiral. As the system evolves and is maintained, the need to repeat the certification process represents a significant
time target detection and data optimization algorithms. The system uses an efficient combination of DSP/FPGA, low power ARM processo
analysis approaches, • to demonstrate a prototype model assessing the feasibility for use in an integrated Reuse Planning Tool, and • to pr
tems including the Navy’s Commercial Broadband Satellite Program. The tool will analyze the amount of generated traffic and the transmis
tween the sun and the target plume of interest and second, the scene must be bright enough to ensure images have sufficient contrast rati
nes by specially-equipped WP3 and C-130 aircraft. Future advances in the accuracy and capability of Numerical Weather Prediction (NWP)
roxy &#61607; Measurement-Based Admission Control • to establish a simulation environment for analyzing potential algorithms • to dem
hnologies that should result in durable, lightweight, Li-Ion batteries with significantly increased life performance at elevated temperatures.
omponents from mainstream suppliers, and our deep knowledge of real-time systems. The primary tracking device will maximize the use o
on, user interface design, above- and sub-surface communications, efficient integration of components from mainstream suppliers, and ou
 a process by which stable isotopic signatures are combined with traditional hydrogeologic parameters and utilized within a three-dimensio
loss less than 5 dB for signals of interest anywhere in the 30-88 MHz frequency range, and compact size to meet the 18 inch x 18 inch x 4 in
meters. Commercially obtained cylindrical printing rolls have cavities originally designed to hold ink for commercial printing. These cavities
communications channel with extremely low RF passband insertion loss and very low refection in both the passband and the stopband.
sents a second proprietary technique to further mitigate cosite RFI by filtering out spurious transmitter products that fall in cosite receiver c
PO43&#8722; polyanion with a strong P–O covalent bond provides not only excellent cycle-life but also a safe system. Further, olivines are
greater than 50 dB, low impact on receiver noise figure, and fit in less than a 7 U high rack mount unit for each direction-finding receiver c
g. Yardney has extensive experience in requirements for battery power and metal-air cells. We specialize in lightweight batteries used in aer
ed by the currents. In Phase 1 of this STTR project we demonstrated that, despite natural variability of sea surface roughness, large-scale o
s by focusing on increasing the energy density of these cells. Our high-energy air cathodes, with an increased oxygen diffusion rate, are inc
n will include both centerline fuselage applications as well as designing a pod based system.
r. The proposed unit will have THz average power greater than 1 mW and signal-to-noise ratio with real-time detection at 10 meters better
sors, and man-portable applications. The proposed meso-hydraulic-based technology is unique because it: • Represents a breakthrough in
ONA-developed Cartesian Euler solver fully integrated with a ZONA nonlinear futter/LCO module (NLFLTR). The Cartesian grid/ boundary c
called NANSI.AE, has significant novelty and merits in that it integrates multidisciplinary domains including nonlinear structures, computati
rately measure the runway defection and correctly evaluate the load carrying capacity of any runway to give a go or not go answer for a cl
engths in a device with centimeter dimensions. Innovations include the use of semiconductor quantum cascade lasers (QCL) that operate
significant impact to the outcome of the future battlefield since the battery is one of the key factors in the digital battlefield. The higher ce
gy density for both high rates discharging and charging. The unique combination of nano-cathode and nano-anode materials provides exce
nt brake to accomplish the same result as the water brake and fit in the existing allocated water brake spaces. A unique combination of mat
bution of deuterium in the sample directly ‘maps’ defects in the material. This finding provides a revolutionary tool for materials assessme
body temperature in long duration cold water dives. In extremely cold water diving conventional foam neoprene glove are inadequate for p
ce Synthesis and evaluate the integration of that technology into the contractor's assembly design.
arameters which are necessary to evaluate new FPA and readout designs in an efficient manner. This brass board test set enables a new te
e designed to provide portability across alternative foundries, newly developed processes, and diverse combinational and sequential digita
hat are not visible under intensity-only imaging. We have also shown how the PLADAR system can distinguish between parts of a scene tha
base material. The instrument’s real-time operation allows the coating removal rate to be unimpeded and to proceed at its optimum speed
r will come with a matching cup, but it will fit any generic insulated cup. The key innovations required for the development of the heater a
design, and hierarchical command and control program based on the NIST Real-Time Control System RCS. The proposed work will detail th
these IRFPAs, but presents numerous challenges, including trap-assisted tunneling which results in excessive dark currents. Such defects in
titative demonstration of increased hydrogen production rate, reduced operating temperature, and increased reactant conversion relative t
th a motion base in a deployed setting, compounding the problem. In a natural setting, our bodies sense motion through the visual, propri
olume of air through a compact space in a short period of time. For this Phase I project, Infoscitex proposes to develop new broadband noi
urse of a day and throughout the year. Volume fuctuation within the socket can lead to issues for the amputee, including decreased comfo
due to sand and rain droplet impact damage and have also not been capable of thermal deicing. Infoscitex has already demonstrated its n
grate multiple personal protective equipment (PPE) measures to minimize likelihood of infection; however 100% compliance is often not a
on and symbology on the helmet. The neck load limits under operational conditions are unknown, so the Infoscitex team is developing a m
m hypochlorite are readily-available in large quantities, their hazardous nature places significant burdens on military operations in terms o
l. The current test for TSE is a post mortem diagnosis looking for protease-resistant PrPSc in brain tissue by immunohistochemistry. The an
al stage. An effective system must be covert and ubiquitous; while encoding complex interaction information and supplying distinct identifi
acks, specifically the exploitable denial of service attacks (DoS) in wireless environments. In this research, we propose a novel scheme that
ucted through bone in the anatomy of the head and face. Air Force fight personnel and other military personnel are in considerable need o
y direction by as far as 4 ft. (c) A robot seat frame, using four pneumatic control rods to control seat frame motion, provides adaptable sup
are restricted even further when applied to adhesives in the optical path, as is the case for solar cell coverglass adhesives. As the power sy
gy that will make it possible to exploit the huge number of raster maps available and use them for imagery analysis. In particular, we will d
real time. For this purpose, we propose a subaperture-based method via which a Moving Target Indicator (MTI) is generated based on a ra
. The benefits of this approach include better resistance to vibration and shock related wear, and inherent EMI shielding. There are also sec
 ding their widespread use. Infoscitex (IST) is developing a rapid aptamer production process to make selection of high affinity and selective
e development a novel composite armor material system that demonstrates excellent ballistic performance at a low areal density, while en
d processing techniques to evolve a cost-effective product for relatively small size UAV or OAV applications, with a weight goal of < 10-lbs. T
experimentally validated those methods with experiments with a real robot on real terrain with varying coefficient of friction and step heig
ands or in spit cells. This goal is motivated by the observation that significant differences currently exist between promptness of results fro
ort mission planning tool that provides an interface for mission planners as to the risk associated with particular mission profiles would be i
uch liquid they have left, leading to hoarding or running out, both of which can lead to dehydration and the concomitant physical impairme
avoid their exploitation in such a way that may reduce a weapon system’s effectiveness. In this Phase II SBIR program, Infoscitex Corporatio
cally, we will tackle the issues of aberrant vestibular signals and of G-LOC training. Aberrant vestibular signals are caused whenever a subjec
nctionally graded, multilayer coating with precisely controlled material nanostructure and composition ratios. This coating protects metal e
y kinetic sources such as ocean currents and waves, and high frequency sources such as ambient vibrations. Initial projections indicate tha
undancy and complex algorithms to achieve the highest accuracy they can. Infoscitex has developed a novel biomimetic sensor that can b
val Special Warfare, Marine Special Operations Command (MARSOC), and the Maritime Civil Affairs Group (MCAG) within Naval Expedition
terms of providing a long endurance, regenerative system. We propose to investigate a variety of approaches to improve the cycle life, reli
Phase I program, Infoscitex will characterize the damage mechanism to advanced solar cell arrays and evaluate active responsive thin film
ring their missions. Similarly, ground crews, such as regulars, maintainers, bomb loaders, and aeromedical evacuation personnel operating
over the range of 7 to 3 ppm/K. This material is proposed as a spreader and as a natural circulation cooled heat sink to be integrated with
over the range of 7 to 3 ppm/K. This material, with strategically located high TC “z” inserts is proposed as base plate heat sinks for advanc
osure to infammatory mediators, we demonstrated that a number of PC-NSAIDs were more effective than the unmodified drugs in reducin
nce phenomena.
n, which likely will lead to a higher Figure of Merit defined by the U.S. Army. Similar metallic fakes are made at tonnage scales for demand
s C. The remaining 40% of the energy is converted to heat. With the development of high performance thermoelectric materials, it now a
which likely will lead to a higher Figure of Merit defined by the US Army. Similar metallic fakes are made at tonnage scales for demanding
o confirm feasibility for both high isolation (>30 dB) and low loss (
gn and analyze PhC modulators based on highly stable advanced NLO polymers and demonstrate the feasibility of achieving low voltage (e.
dition of vibration monitoring can provide a localized prediction of exactly which component is degrading or failing. Data fusion of vibration
Structure Technologies (MicroST) in conjunction with Oregon Health and Science University (OHSU) has demonstrated a two-step nucleic a
research, PHM diagnostics and prognostics have been shown to be feasible in tracking day-to-day engine health; it is expected that real-tim
and test a prototype that has the potential to surpass all current electric propulsion systems in efficiency, power, and thrust. The thrust is p
aser eye protection device designs are proposed and will be examined in detail in the course of the Phase I program. Each device exploits a
and display) that offers the best leverage of commercial technology. The Sage team will take advantage of recent developments in SWIR dig
enarios include attacks on theater assets and our allies, the BMDS architecture must address the perceived risks of harmful fallout from inte
techniques to identify resonances, distinguish acoustically and mechanically driven vibrations, and discern electrical faults from mechanica
he Warfighter. The HyperX Technology is viewed by JPEO JTRS HMS as a risk reduction technology that is slated for insertion into the JTRS H
essful proof of principle conducted in Phase I and to build, test and validate a prototype for Titanium Gas Metal Arc Welding (GMAW) for I
ncreasingly characterize their missions. A second intent of this proposal is to design a comprehensive training strategy that targets particul
corporation into existing Core Lethality Models to increase simulation functionality and better predict missile defense strategy effectivenes
whisker caused short circuits on electronic assemblies. Development of a new conformal coating that successfully prevents tin whisker pen
h as 20 lbs), which when added to their usual 80-lb packs, represents a crushing burden resulting in reduced performance and back/joint in
topology for mesh construction are manual processes and place the heaviest demands on time in the analysis process. The need to gener
nerators and associated electrical systems. The PHM will be based upon a set of recently developed tools that include a novel sensor to me
allows us to develop a prognostic capability for the electrical power system components without the great expense of running component
s fibers with rectangular cross section) of matching refractive index. The objective of this proposal is to use this technology to produce nea
ated by moving humans. We will also develop detection algorithms that can leverage the decentralized use of multiple mobile sensor platfo
l no-fire acceleration profiles, including those due to accidental drops, transportation and handling, as well as acceleration profiles defined
etometer uses the earth’s field as the illuminating source, an EMI sensor emits its own time-varying magnetic field and, thus, has the name
urther, our approach is resistant to node mobility thanks to the intelligent link management scheme. Our research on IEEE 802.21 shows th
 er gain than conventional dipole antennas in less than half the linear dimension. The proposed array provides superior performance desira
hnologies including active and passive RFID tags; agile scanners able to read barcodes, and a variety of RFID tags; innovative RFID shelving;
ugh continuing research, the Task-related Effects of Encumbrance Methodology (TEEM) project plans to continue creating methodologies a
ag all pallets and cases of Class VIII (Medical) materiel is not expected to occur before the end of 2008. The DoD mandate not withstanding
maging applications. The key components of the Program will include evaluating new and innovative device design, modeling, growth, fabri
ve good low-temperature and high-temperature properties. The objective of Phase II is to extend the technology to enable commercializa
ments and produce a viable core. Alliance Spacesystems, LLC produced a rotary percussive drill designed for space use under a NASA-fund
ting behavior which is the equivalent of eating. It can find, ingest, and extract energy from biomass in the environment (and other organic
QIF-based LNA with HYPRES all-digital receiver, similar to that recently demonstrated at TRL-6 with an Army JSEC X-band terminal. In this P
II, we will use this approach to estimate battery capacity and internal impedance, the key factors in determining battery health. We will al
e of this order is shown to be required to distinguish various materials. Fewer Stokes parameters can be collected to reduce the noise level
g the performance of each miniature electrically initiated inertial igniter concept to all no-fire acceleration profiles, including those due to a
Existing blade tip clearance measurements are generally limited to much lower temperature operation. The small and robust single crysta
illance locations of importance to the military are remote, it is hard or impossible to find a reliable, field-deployable supply of CO2. Current

ecies of concern in the Gulf of Maine. It is inevitable that commercial and recreational smelt harvesting will be further restricted or halted a
, this causes significant coincidence artifacts to appear in the spectrum, thus complicating analysis. Phase I will design and demonstrate an
guides with a long wavelength (1800nm) pump leading to higher efficiency single photon detectors when used with Silicon-based avalanche
cting and tracking of marine debris, sea-life or other objects in the open ocean. Using anomaly detection software, the UAS will be able to
ng task. In this proposal, we discuss an approach to designing a computer program that would solve this problem by allowing multiple prop
mponents of the light. the light is then recombined to form complex spectral signatures. Due to small pixel sizes and binary operation per p
Bridge, will have an operating current range from 0.1mA to 10mA user selectable. It will have two measurement ranges: a 40-ohm range (
to establish the feasibility and utility of such work for the validation of supply chain management messages, as well as for other, related fo
mbines a detailed analysis of the optical and electronic systems with a laboratory validation of the optical designs.
transmits. Deployment methods are extended to mounting on predators to monitor interaction with prey, static mounting on the sea-foo

th nanopore sequencing, some fundamental instrumental and system problems have so far kept the method from realizing its potential. Th

SiC nanowires will be grown by choosing appropriate substrate materials as well as tuning the Si/C molar ratio in the precursor species. Th
r for CCR use. The technical innovation will be to develop a reversible rechargeable sensing electrode in a solid-polymer electrolyte configu
ump to deliver water to a fow-through multi probe sensor and additional instruments such as nutrient monitors. It provides for environme
existing propagation modeling codes that have a long history in the underwater acoustics community. Due to the complex nature of the o

e the feasibility of developing a cost-effective, battery operated hydrophone offering a SNR > 5.
ing regimes, and improve overall survival to metamorphosis. Refined diets and passive larval grading mechanisms will be tested to reduce
er. Precise temperature control and new types of crystal sensors will be used to greatly extend the temperature range of operation, reduce
ed using fuoride glass fibers; optical absorption by the fiber prevents longer wavelength output. Challenges to extending SC sources to the
le but still problematic. The application will make use of Ensembles of Decision Trees (EDTs) to mine the data and detect those anomalous
ng new and novel combinations of magnetic materials, in conjunction with proper post-deposition thermal magnetic treatments, the free la

pe automated operations system for marine finfish net pens. Automated manipulation of the AquapodTM net pen will allow remote morta
f pressurized air. OFT¿s AquaPodTM containment system utilizes air for positioning in the water column and for rotation to support cleani
as already been completed showing performance parameters better than NIST requirements. The linear displacement precision was shown
n method based on the use of carbon nanotubes to rapidly identify fish from very small tissue samples. The Phase I part of this project wil
hanced optical fabrication capabilities to build advanced VIPA prototypes that improve upon each of these areas. A photolithographic mas
dissemination of the lightning probability or threat risk, and assess the feasibility of nowcasting lightning risk using current storm track featu
rtners, will require ten high performance receiver channels, which must be compact and low cost. During Phase I, ProSensing developed a
e of the largest natural threats to our society and economy. The NOAA research aircraft carry several NOAA and other radar systems design
water management models or the streamfow period of interest. Commission of system focused studies, are prohibitively expensive for m
l be about ½ the size of a business card, a few mm thick, and will operate for at least a year using a lithium battery. Volume production w
y necessary to ensure a reasonable lifetime of continuous use. The Techshot solution for a High Pressure Specimen Chamber is a solid desi
techniques to optimize a thin film absorber to enhance the detector absorptivity without substantially increasing thermal mass. Also, a me
quantities of sensitive nuclear materials, but the limited spectral resolution of conventional alpha spectrometers limits their effectiveness to

s. The use of closed circuit rebreathers provide many advantages over diving using traditional open circuit SCUBA, the major one being inc
t pass. A second approach creates a carbon barrier that is formed during the fire. The carbon barrier is formed through the carbonization o
aser pulses and highly anisotropic hydrofuoric acid etching. We propose to use this unique knowledge to fabricate in-fiber Fabry-Perot filte

MCR: if the APD is cooled to reduce DCR, then its dead time must increase to avoid afterpulsing, which reduces MCR.

n exhaust research, and plasma diagnostics for semiconductor fabrication.

Environmental Protection (EPA) and state regulations.
o use the database as a tool for identifying contaminants in unknown situations (class prediction), which may lead to an interpretation of hu
rms manure management strategy, several sources have stated that farms of this size are incapable of feasibly maintaining anaerobic diges
tive test interpretation (readout). BioTex will first develop aptamers for highly sensitive and specific binding to anatoxins and then optimize
al politics, policies, and prices for energy from all sources, the availability of our technology could impact the future of biomass fuels in Am

entical. Thus, controlling emissions from commercial cooking by this approach will, like catalytic oxidation, enjoy modest costs. The one imp
onitor program. In addition, bacteria, toxins, pesticides, cyanotoxins and explosives have been effectively detected in water. The ability to m
e in electrochemistry and, specifically, in electrolytic water treatment systems. The existing technology and experience will help to speed d
n of Phase II, Eltron anticipates that, working with a catalyst manufacturer, a prototype system for field application will be completed.

ects of toxicity. So far, however, microarrays have been employed mainly to identify the mechanisms of toxicity. The aim of this work is to s
d replace 20 percent of the nation¿s petroleum consumption. Cellulosic biomass is an attractive energy feedstock because supplies are abu
hod that requires neither a radioactive source nor purified PAN for calibration. Finally, the general approach may be adaptable to other type
tection limit of 2 ppb could be used for applications intended to control microbiological growth in a number different industries, such as th
ossible to obtain near real-time results in a portable, field use format. The objectives of the proposed study are to demonstrate the use of t
ey afford would decrease particulate emissions to the atmosphere and/or decrease the cost of precipitator installations. This would represe
ults. technology can be developed which converts glycerol into green propane at uniquely high yields, producing a high valued biofuels pro
dustrial sized testing trials will be negotiated with companies such as Johns Manville to process the required amount of G-sand in order 10
water are lost out the stack in the US today, since no conventional condensing technology is economically viable. In this proposal, we prese
s of magnesium chloride (MgCl2), which requires storage and transport of liquid Mg as well as handling the chloride gas produced. The Kro
chlorite for wastewater cleanup.
ompete with diesel in the automotive arena, should oil prices continue to rise.

a strong market in the e-waste recycling industry.

he MVCO injector is potentially an effective low-cost solution for new engines and engine retrofits for NOx reductions.
ons per year by 2015. However, existing feedstock shortages are increasing soybean oil prices and alternative and less expensive feedstocks
eanup of toxic industrial chemicals and materials.
y protocols for commercial GPSS authentication and the registry service. In Phase II, preliminary protocols, along with Web-based tools, wil
The burn temperature of burnboxes is thus considered to be a primary factor in their poorer emissions. In Phase I, Tok Welding and Fabric
s of magnesium chloride (MgCl2), which requires storage and transport of liquid Mg as well as handling the chloride gas produced. The Kro
 ts&rdquo; and to use the database as a tool for identifying contaminants in unknown situations (class prediction), which may lead to an int
ossible to obtain near real-time results in a portable, field use format. The objectives of the proposed study are to demonstrate the use of t
y protocols for commercial GPSS authentication and the registry service. In Phase II, preliminary protocols, along with Web-based tools, wil
e in electrochemistry and, specifically, in electrolytic water treatment systems. The existing technology and experience will help to speed d
tive test interpretation (readout). BioTex will first develop aptamers for highly sensitive and specific binding to anatoxins and then optimize
fic and global effects of toxicity. So far, however, microarrays have been employed mainly to identify the mechanisms of toxicity. The aim of
entical. Thus, controlling emissions from commercial cooking by this approach will, like catalytic oxidation, enjoy modest costs. The one imp
ey afford would decrease particulate emissions to the atmosphere and/or decrease the cost of precipitator installations. This would represe
ompete with diesel in the automotive arena, should oil prices continue to rise.
Environmental Protection (EPA) and state regulations.
n exhaust research, and plasma diagnostics for semiconductor fabrication.
n of Phase II, Eltron anticipates that, working with a catalyst manufacturer, a prototype system for field application will be completed.
d replace 20 percent of the nation&rsquo;s petroleum consumption. Cellulosic biomass is an attractive energy feedstock because supplies a
ons per year by 2015. However, existing feedstock shortages are increasing soybean oil prices and alternative and less expensive feedstocks
a strong market in the e-waste recycling industry.
burn temperature of burnboxes is thus considered to be a primary factor in their poorer emissions. In Phase I, Tok Welding and Fabrication
al politics, policies, and prices for energy from all sources, the availability of our technology could impact the future of biomass fuels in Am
chlorite for wastewater cleanup.
onitor program. In addition, bacteria, toxins, pesticides, cyanotoxins and explosives have been effectively detected in water. The ability to m

for cleanup of toxic industrial chemicals and materials.

dustrial sized testing trials will be negotiated with companies such as Johns Manville to process the required amount of G-sand in order 10

ults. technology can be developed which converts glycerol into "green" propane at uniquely high yields, producing a high valued biofuels p
etection limit of 2 ppb could be used for applications intended to control microbiological growth in a number different industries, such as th
water are lost out the stack in the US today, since no conventional condensing technology is economically viable. In this proposal, we prese
rt” instrument systems for component diagnostics and prognostics, aircraft engine health monitoring, and aircraft health management. We
dynamically to support online health monitoring and prognostic health management. Our existing approach, called “Data Driven Diagnosti
to a radiation-hard ASIC chip installed in either connectors or LRU. The EPIC module is small enough to reside in the backshell of a M38999
intenance induced breaks” when, for example, a heavy object falls on them or they are bent sharply at an anchor point. Both these situatio
rolysis. When pulled through conduits or been installed tape insulation edges tend to catch on even small protrusions. This can be solved w
of regard (FOR).
uring the downward fight of a guided munition, a body-fixed, boresighted imaging sensor detects the expansion of the scene as the muniti
nd reliability. Arete Associates is developing frequency-stable Optically Pumped Semiconductor Lasers (OPSLs) to meet these specifications
ncluttered areas suitable for a helicopter landing zone. These processed data can then be distributed to a feet of helicopters to plan a safe

ticles that impede visibility. These conditions can escalate into crashing descents, lateral drift rollovers and collisions with ground features o
ent operational configuration. This requires small, light, expendable vector magnetometers with sensitivity comparable to the larger, more
reat. In the case of sniper detection the urgency and importance is exemplified by the existence of no less than fourteen different systems
ting, has established an undeniable value that UAVs contribute to the war fighter in the combat arena. With micro-UAVs among the newes
o predict. Additionally, relatively little empirical data is available on the thermal properties of disturbed soils that can be used to paramete
ties and/or time on station. Areté Associates has developed a set of innovative concept designs that mitigate the performance limitations o
ystem methodologies and leveraging core capabilities, Areté proposes to design a self-aware, agent-based system for development, paralle
ntifying and imaging targets at great range. Ladar based ISR systems may also serve a critical role in detecting underground facilities by sen
s will be used in Phase II to develop a standalone C++ application running on standard PC platforms. It will feature a modular, extensible ar
eamed with USSI, Arete Associates will design the hardware and detection algorithms, predict performance, and conduct testing in realistic
ecessary input to the algorithms that are used to generate the requisite environmental products. There is a need for data collection system
deployed for a period of up to a few days without failure. Communications between sensors and their base station will be via satellite link
ASW) aircraft to search, localize, detect, and track submerged targets more effectively. IMaQS will eliminate the need for a towed sensor by
tics associated with remote sensing of the interaction of Kelvin wakes from boats with river bottoms. This program will develop a passive r

Soldiers and junior offices to learn key aspects of culturally-infuenced behaviors that can impact their ability to successfully communicate a
Science Dictionary, developed by TERC and Vcom3D, aswell as explanations of multi-sense words and English idioms. Initial testing of the M
eratures; and the dispersment of the loosely agglomerated particles for commercial applications. The synthetic method will be, low cost, e

a acquisition systems. Concurrent analysis enables fine temporal information to be extracted without the need to save data at a high temp
Sharing visualizations largely consists of a single knowledge worker exploring and transforming the data, choosing a single view or a small
crop yields, decreased quality and quantity of water resources, and increased risk of forest fire. A better understanding of the climate syste
rces and sinks of these dominant greenhouse gases. Such knowledge is needed to improve predictive models that lead to a better underst
c phosphors. The proposed methods are suited for use on both coated and uncoated specimens, and will be designed around thermo-mec
he feasibility of employing hollow core optical fibers to deliver pulses capable of generating CARS signals. This all-fiber-optical CARS system
ment is a convenient method for characterizing this roughness. However, there still exists a significant gap in the modeling capability due t
ument has already been established with solutions to the major technical hurdles having been demonstrated. This proposal lays out a path
proach for a TIL method to be applied for effective compensation of deep, turbulence-induced laser beam aberrations. The effect of comp
rge field of view, and are the preferred methods for outdoor schlieren systems. One schlieren technique for large field studies is the use of
terrogates them after a short delay to determine the velocity. Since the markers are molecules, the method measures the gas velocity direc
roblems and associated inspection needs for such components, including manufacturing, assembly and complete optical characterization, a
ve compensation of laser beam aberrations in TIL systems. It is based on a recently devised technique that combines optical phase conjuga
sensor will be developed for use in the range of 700 – 1200 degrees centigrade, with a temperature resolution on the order of 30 degrees
onents for easy mounting at multiple locations along the test range. It features digital imaging and automated data reduction software tha
or system can be triggered externally by the rocket sled as it travels down the track. This gives it an advantage over other rotating systems
technical feasibility of the proposed instrument has already been established, with solutions to the major technical hurdles having been d
mprove optical system capability. Since the optical tolerances achieved in the manufacture of such components have an important bearing

time-scale modification algorithms, which provide good quality with less computational complexity compared to other approaches such as
onversion algorithms; thus laying a good foundation upon which this Phase II project can be successfully implemented. The objective of th
re useful, but we additionally propose supporting fexible and natural multimodal transmission of intra-squad communications, and utilizati

niques to automatically build social networks while also understanding the context they represent. The Decisive Analytics Corporation (DAC
obscuration problems that create gaps in coverage. Both of these problems cause frequent track losses, motivating the need for two spec
BMDS; and (3) is compatible with future system requirements for which there are no current algorithms in the system. Our approach is roo
mination within a single Bayesian network model, we propose the development of a high fidelity, multi sensor fusion framework for integra
blem. In particular, our STTR product provides cutting-edge adaptive mesh refinement (AMR) capabilities, and our Phase I results demonstr
munication bandwidth requirements. The DECISIVE ANALYTICS Corporation (DAC) team proposes to overcome these real-world problems t
ll allow warfighters in the field to easily reconfigure the prognostic tool when “plug and fight” hardware is reconfigured on the battlefield.
nowledge about the world: we are more often than not uncertain about our knowledge to some degree or another. Dealing with uncertain
eapon/target allocation problem is not sufficient. An automated engagement management tool must be able to process and respect the gu
as been undergoing a transition from a traditional “platform-centric” force to a Net-Enabled Command Capability (NECC) based upon a Ser

apture and programmatic data input is a primary obstacle in the production deployment of these systems, often delaying critical productivi
newer weapon systems are overhauled, repaired and reused directly or indirectly to aid the war-fighter in the existing Global War on Terro
 being widely deployed. This Phase I project will customize a TELE to a) provide science lessons for middle school students while increasing

. Specific objectives are to: (1) improve the design of the baffle so that it can travel freely as well as address issues with fish movement, cro
ercial fisheries and hatcheries.

causes consumers to lose faith in the seafood products they purchase, which in turn has a tremendous negative impact on the U.S. seafoo
y identifies red snapper from related, commonly substituted snapper species. Our diagnostic design strategy leverages the power of PCR an
cially marine species. Thus, nitrate removal by denitrification presents a pressing need for the continued expansion of intensive recirculatin
se to major markets. These systems can also be operated in a biosecure manner unlike other forms of aquaculture. Recirculation aquacultu

service learning generally are theorized to include improved citizenship, and applied learning in areas such as math, science, and social stu

ish sperm exhibit faster growth, improved feed conversion efficiency and improved disease resistance and yield as compared to traditional
amining colonies for pollination, for honey production, for queen rearing or for overwintering assessment can not be overstated. Project o
or will be designed for placement in stored grain structures to continuously monitor CO2. The readings will be processed intelligently to giv
collection for the software modeling. Commercialization of this device will allow new protection of the US grain yield during post-harvest s
. All currently available iron supplements have limitations related to side effects and poor bioavailability, particularly in these vulnerable in

nalysis of children’s responses that will compliment the CPAA. The error analysis will target errors associated with the child’s understanding
oval of water (program goal of 50%) and showed water removal dramatically reduced deleterious acid formation. Systems showed excellent
positions the program for Phase II and commercial success.
g value added products.

ble system utilizes existing and developing technology, improvingthe ability of a person who is deaf to function more naturally in a work or

ining the soil pore structure information necessary to estimate soil WRC directly from soil images. The proposed approach minimizes the r
hnological options.
s for heating In order
buildings usingtoasuccessfully
farm tractortransition
to convertthe
theU.S. to a predominantly
biomass biofuels-based
into a dense solid manufacturing
fuel called biomass andusing
logs, and transportation econom
a fully-automated
ment being commercially available, this new technology will gain widespread acceptance by American farmers. Because biomass is a renewa

ods for testing require shipping samples to centralized laboratories to perform PCR or histology that is time consuming, expensive and requ

s (RP) merges subunit and modified live technologies to safely induce protective immunity by mimicking natural infection. The PD and colla

roduce postlarvae to conduct on-farm trials at two commercial shrimp farms in the U.S., one in Texas and one in Hawaii.

ed funding, and the lack of proximity to service providers

oyees, clients and customers, (3) develop business processes and support materials for delivering the software and planning services, and

rlysis
sampling bags. grains
of distillers Published studies have
for potential indicated
use in thatfeed
local dairy thismarkets.
approach is not appropriate for this application due to the rapid loss of critical s
plant."

esentation of a dynamic system, which fails to accurately represent the true relationship between the model and physical properties of the
n their hands.
 thorough review of the economics of vermicompost tea production and marketing. This will provide a major innovative boost to OSC busin
ot otherwise allow for future upgrades or replacement of initially installed utility distribution lines. The BIN would therefore support and e

ent i.e.,the wind energy required to cause particle movement.Existingsaltation sensors are positioned vertically above the surface at some
e productivity. Supplementing carbon dioxide makes light more effective and less is required. However, ventilation for temperature control

em, (PRCS), employs low energy digital x-ray radiography together with specially formulated artificial substrate and container materials in or
are interested in characterizing the PRCS performance and limitations for tree root research. In Phase I, NCRS and PSC compared Poplar tre

experiment, including animations, brief video clips, and simulated laboratory equipment and data collection tools that allow the students to

ce homologous recombination is a normal occurrence in meiotic cells, the vector is expected to serve as a recombination substrate, resultin

le the loading of all passengers, regardless of mobility, from a wide range platform configurations. In Phase II of this SBIR program, Safe pro
ns to substantiate the use of particular volatiles as markers of afatoxin contamination.

ildren of poverty who have small vocabularies relative to their peers.

uction of improved insect host media, host inoculation, nematode harvest and packaging. The project is focused on producing nematodes i
hropod biocontrol agents, the potential is vast.
k and web-based data collection of observation notes and other observation instrumentation.
d webbased data collection of observation notes and other observation instrumentation.
elective rodenticide products to assess their scientific merit as well as their target efficacy and their non-target safety. Further, we intend to

practice. An example of how TILE might be used when learning about forces and motions might involve students driving race cars and then

n, 2006. However, for more sophisticated markets, such as oil removal from water, melt blown polypropylene is the material of choice. The
 digestion and hydrogen production will be high rate and third the process will involve a continuous fow through system rather than a sequ
nket reactor (IBR). The technology for the IBR was developed and patented by Carl and Conly Hansen. If successful the total energy produc
ogens.toWhile
ation adjacent
somebarrels andvaccines
of these the central
havecommunications computer.others
proved to be efficacious, The other
have key componentsub-par
demonstrated of the system, the central
immunogenicity andcommunications
protection. BG
affects commercial aquaculture species such as rainbow trout and salmon. To date, there is no effective vaccine against this pathogen and d

olyte balance prior to handling in a laboratory trial significantly reduced the number of non-ambulatory fatigued animals. In this trial, incre

res of the source including pulse width, reproducibility and neutron yield. The commercial goal is to develop a replacement to existing neu
ed only through the coordinated effort of hundreds or thousands of computers. AccessData has developed such distributed code breaking s
bled by the DOD investment in 3D LIDAR at LMMFC and in eye-safe fiber laser sources at Aculight. The combination of these two technolog
n yields can be otained depending upon the RF generator used. Using the T-T nuclear reaction, a novel emission geometry and an ideal acce
provided a solution to this deepwater surveillance problem with a lowcost distributed buoy vessel detection and tracking system based on
scue crews everywhere. Hale Products presently own the trademark Jaws-Of-Life though now a generically named rescue spreaders. The p
ology would be used, thereby enabling rapid and cost effective deployment. Advanced Fuel Research (AFR) and Vidiation LLC developed an
coast guard) environments. A device that is portable, lightweight, secure, accurate, inexpensive, easy-to-use, and has a long battery life is d
ily retrofitted to commercially available detectors and require minimal electric power as well. We estimate that its use will increase detecti
ploy reconfigurable
are, computing
multimodal biometrics. Theand hostbased software
development to provide
and testing a comprehensive
of the new and extensible
multimodal middleware platform
application against
with such
remote attacks.
sensing willThe
bepropo
comp
dented performance. We have already internally developed a proprietary and demonstrated trace explosive detection technology, and wh

ical dispersal devices (RRD). Nowadays, radioactive sources are supervised using video cameras and sensor networks that signal the presen
and timely information creates an organizational nightmare for incident commanders responsible for the wellbeing of their team. Experien
eters are an important tool in homeland defense and monitoring to check the spread of special nuclear materials (such as highly enriched
ents an enormous challenge to current detection methods and monitoring technologies that have to be substantially improved to demonst
nuclear weapons is to detect and identify characteristic signatures of highly enriched uranium and weapons grade plutonium. Neutrons an
ech, Inc. (ANI) proposes to develop a novel field ionization technology to produce the deuterium ion (D+) current for a neutron source, ena
he CNT ion source technology, demonstrating an ionic current at atmospheric pressure exceeding the capacity of a 10 mCurie 63Ni beta sou
ss networks relies on strict physical separation of networks. The approach of using trusted operating system platforms and automated guar
functionalization of the SWNTs their sensor properties can be tailored for enhanced sensitivity against small gas molecules. This concept e
ng the vehicle. Inducing a car to stall without permanent damage generally termed &ldquo;vehicle upset&rdquo;. Our goal is to defuse a po
tions. In addition to being able to increase speed, the solution is also highly scalable, as up to 28 of the recommended FPGAs can be used i
a system that can do that based on a multitude of input feeds such as sensors is of outmost importance. While sensor put out information,
nging inter-organizational email with attachments. It will 1) prevent improper disclosure of an organization¿s sensitive information, and 2) p
and scanning malware without risking the end systems. A hybrid analysis approach uses both Pattern Recognition and Control Flow Graphs
nsider the kinetic energy of the vehicle being stopped. This means a large large truck can potentially exhibit more than 10 times the energy

bination of experience in security, web-enabled applications, and high performance computing will ensure that we will successfully comple
ew design may opt to have the same penetration as with conventional sources, but to produce about a factor of 3 less radiation. Another o
tterned silicon, which forms the substrate for these devices. In particular, this process will be applied to the highly efficient neutron detecto
me human health diagnostics and decision support software will be developed while leveraging existing COTS sensors, wireless communicati
nd 3) collection efficiency for small particles. In addition, the real world problem of collecting unwanted contaminants must also be addres
smoothing algorithms and is robust to noise. It can differentiate the signal from the spike and colored noise and the signal-to-noise ratio ca
l positioned to introduce this new technology into a wide variety of military and commercial applications.
e wide monitoring and control applications, such as oil and gas, cold chain, and machine health monitoring. The fexibility and adaptability o
be used to detect blasts and issue an alarm. Placing sensors in a tunnel is challenging, however. Long tunnels require many sensors, which

are, reconfigurable computing and hostbased software to provide a comprehensive and extensible platform against such attacks. The propo
hardware, but without the deployment and cost of a custom addin board. The end result will be a significantly better protected infrastruc
 benefit from a longer range (6 to 40 meters), non-tethered electric stun projectile. The introduction of tasers caused sharp decreases in in
ers often carry a lot of luggage. X-ray machines and computer tomography-based systems currently deployed by TSA operators provide onl
ntech proposes an infrared imager with a wide field of view which is designed to complement FLIR to increase the probability of detection
e would provide individual threat control at increased range (40 50 meters) over existing weapons and compatibility with 12 gauge shotgun
e contextual knowledge obtained from real-time aggregated botnet intelligence data and cybersecurity infrastructures but also contribute t
ates neutron streaming and other undesirable effects of previous perforated coated-diode type detectors.
s recur. In Phase I of this project, we will conduct a feasibility study and develop a proof-of-concept software system that is applicable to m
In this Phase I project, we will develop a new generation of stable chemisorptive sensor materials that are highly sensitive towards reactiv
or expertise in high speed scintillators and coupled light-sensitive readouts; and the Remote Sensing Laboratory operated by National Secur
g materials for the detection of small molecules gases. The Phase I goal is to develop the feasibility of an improved chemiresistor sensor arr

st of ownership are lacking for critical special nuclear material (SNM) interrogation and verification processes. With the availability of new
ll replace isotope-based gauges for thickness, level, and velocity measurements in materials such as polymers, glasses, and ceramics. The d
d particulate trace explosives on/in a highly functional nanostructured porous membrane. It features a throughput of at least six individual
ed by the food industry.
ulation spectroscopy (SRMS) and wavelength modulation spectroscopy (WMS). The key element of the ESD3S is an ultralarge aperture nar
pulsed, eye-safe laser, and will offer the capability to detect human targets on the sea surface with at least 90% probability, even during ha
erns. A primary goal of this project is to establish that; when all technical capabilities of the proposed TD-THz gauge system and all aspects
ncident.
terials. The relative response of the materials will be used in a Quantitative Structure Property Relationship (QSPR) study and the first gene
Biosensor for rapid, lowcost multiplexed detection of proteins and nucleic acids. The Talon Biosensor performs quantitative, immunodiagn
esents a unique opportunity to advance the state of the art both in multi-modal biometric data quality by developing a toolset in which diff
e, will measure the radiation spectrum and intensity at its current location and as it is moved transported/relocated. This data will be repor
k togetherand
as-phase in asolution-based
trusted grid todeposition
provide increased
methods.cyber
The awareness for incorporate
detectors will botnet detection and mitigation.
a p-n junction This system
surrounding boron will
as abe sensor-neutral fac
neutron-conversion
ss neutron detectors for container monitoring applications. In addition, we anticipate that large detector areas can be manufactured at cos
ents to log in a control systems network. The architecture will use emerging wireless technologies which demonstrate superior performanc
es new risks in terms of cyber security. Indeed, as the wireless physical and medium access control (MAC) layers are now standard for man
ding to the NRC, there are about 25,000 of these units in the US. Of these, the GAO reports that 300 are reported as lost or stolen each yea
d devices, but they also significantly limit data processing and communications capability. The development of a global biometrics screenin
argo at any time during the shipping cycle. Triton technology addresses a critical security gap by detecting intrusions in cargo while it is in tr
nces such as passenger and cargo planes, over-the-road trailers and rail cars can also be monitored with the proposed detector. This detect
ergency assistance, or for reach-back from areas without Internet or cellular-network. Low-energy consumption strategy can be designed fo
uely
givenintegrate
the lower two wireless networks:
sensitivities an detectors
of compact on-body static network
and the of sensors
presence thatbackground
of varying collect the physiological measurements
interference in and an off-body
these environments. ad
This resear
horten the time to commercial products and production.
easingly being used around the world against civilian and military personnel and infrastructure. The technique uses ERCo s patent pending
ents. These agents will remain clear while in the film in order to disguise their presence and permit visual inspection of the cargo. If the film
ng stent of bioprostheses cause time dependent structural changes such as calcification and leafet wear, which lead to valve failure. The f

y animal research. Unlike other soft tissues, lungs are difficult to image with MRI because the signal decays rapidly. However, good MRI will
e ulcers. Yet it has been forcefully argued that pressure ulcers are largely preventable regardless of a patient's Braden Risk profile when prop

ty to more RNA-limited material to the point that a single cell can be profiled with confidence. The most widely used method for preparing
mprove user comfort, function, and posture during multiple activities of daily living. The innovative design will enable the user to adjust the
 nd has been a hotbed for the application of data mining and database principles to collections of chemical compounds. The wide adoption
arnings history of the respondent. Under current HRS protocols, the use of the SSA data is restricted. Investigators must make special secur
nefficiencies, transducer element sensitivity; the complexity associated with the driving circuitry and interconnect density. The proposed re
nderlying the central retina (macula). The dry form can progress to the wet form of AMD, which is characterized by the proliferation of abno
n, low-cost, high-performance technology for predicting compound toxicity would help assess safe levels of environmental exposure-thereb
ectric current is spread widely along the scala tympani and across turns limiting the number of effective hearing channels. In the Phase 1,
g of administrative data from the Centers for Medicare and Medicaid Services (CMS) to participants of surveys and registries sponsored by N
g of administrative data from the Centers for Medicare and Medicaid Services (CMS) to participants of surveys and registries sponsored by N
ed nanoparticles, the development of glyco-nanoparticle has been left far behind. Currently the very few reported glyconanoparticles were
at the frontier of glycomics. Microarrays of carbohydrates (glycoconjugates, polysaccharides, oligosaccharides and monosaccharides) allow

t strike a balance between functionality for activities children wish to accomplish and cosmesis for parents who desire their child have a no
cocaine addiction. It is collaboration between Adenosine Therapeutics, LLC, where medicinal chemistry and compound characterization are
pproach as compared to the existing, standard method. Pancreatic islet cell transplantation has received considerable attention as a proced
same symmetry as the pore itself. Previously, we demonstrated that per-substituted derivatives of beta-cyclodextrin (beta-CD) having a se
ble for neurocognitive investigations including traditional neuropsychological assessment (e.g. Halstead-Reitan, Wechsler memory battery)
eatment of OSA for patients with mild to moderate disease severity and for those patients who cannot or will not be treated with Continuo
affecting 75,000 patients and twelve million hemodialysis sessions per year. IDH often causes abdominal pain, nausea, vomiting, muscle cr
number greater than 40. There is a need to minimize the blood collected for screening purposes while maximizing the number of conditio
d wireless links. AME completed on this phase II program the development of a set of production prototype wireless sleep sensors and crea
nce it is impractical for most people to hire a live-in nurse, those that suffer with chronic illness must help manage their conditions. Each da
t promises to greatly simplify the attachment of EEG scalp electrodes. Dry electrode technology will allow a minimally trained person to ma
rehabilitation that does not impede social and psychological development. Technology-dependent, chronically ill children represent a broa
recording using infared (IR) images, surface temperatures and changes in cutaneous blood fow (using Laser Doppler measurements). Thes
characterize limb and torso motion and compare it to stored reference profiles to evaluate adherence to body movement protocols such as
poses and has proven to be a useful tool for investigating neurological pathologies in pediatric and adult populations including ataxia, dysto
ogonal axes. The time history of these magnetic data points can be continuously compared with an electronic map of magnetic anomalies
dular amplifiers that allow either a low noise clinical bandwidth or an enhanced wide bandwidth. It will be comparatively evaluated in hum
y the cancer cells and minimize damage to healthy cells. These targets are critical to the tumor's malignant phenotype but not to the host'
osine kinase inhibitors. 20/20 will utilize its proprietary layered peptide array (LPA) technology. Transfer of antibody probes from a single tis
sitive and specific blood test for NSCLC could be a clinically valuable and cost-effective tool for early diagnosis. The immune system respond

tors. The 293 cell line has been very useful and widely used for making relatively small batches of vector for early stage clinical trials. How

studied and promising approaches. A few dose escalation Phase I studies have shown good safety profiles with encouraging anecdotal res
(OCS), and ethane (C2H6) in the breath have been identified as biomarkers of these diseases, where nitric oxide and carbon monoxide are
atment, and the rates are especially high among the socioeconomically disadvantaged. The metered dose inhaler (MDI) is the most commo
and research remain vital to US public health interests, as well as to global health interests. In the past decade, new, highly-effective antima
problem of significant clinical need and poor clinical significance, new mechanisms of action must be identified for pain therapeutics. Geno
tivity and rising auto accident rates. Clinicians increasingly note the negative effects of sleep loss on cardiovascular, metabolic, endocrine, a
mple diazepam causing amnesia. To develop better therapies and decrease medication side effects, researchers need new testing methods
eality. Perhaps the greatest obstacle is that cells injected into many tissues are rapidly cleared via the lymphatics or vascular drainage. Cells
not only necessitate new surgeries but in themselves present a significant threat to life and limb. The biofilm bacteria that establish themse
rafting is routinely necessary prior to the placement of dental implants. Autograft bone is considered the gold standard because of its osteo
matrix, and osteoinductive molecules. Iliac crest harvest is however associated with a significant number of complications and often provid
as identified as high-priority by the NIA, specifically the Geriatrics and Clinical Gerontology Program, in the 2006 Omnibus Solicitation. The
n important contribution to both the proteoglycan and tissue regenerative fields, with a specific, clinical impact on periodontal regeneratio
n important contribution to both the proteoglycan and tissue regenerative fields, with a specific, clinical impact on periodontal regeneratio
nce books and watches increasing amounts of science TV programming. In spite of the $70 billion investment in technology during the 199
ersonal exposure to pollutants. Further, studies over extended periods of time and over a large population requires the development of a p
ticular interest to Augmentative and Alternative Communication (AAC) device users who depend upon speech synthesis for communication

opioid-induced bowel dysfunction, that limit their clinical utility. Opioid antagonists have shown efficacy in reducing unwanted side-effects
proprietary software as "one of the biggest barriers" to interoperability in the health IT environment, and suggests wider use of open sourc
e expanders require multiple visits and exterior equipment to generate expansion. Current self-infating expanders expand immediately wh
spiratory syncitial virus (RSV), adenovirus (types A-f), SARS coronavirus, group A Streptococcus, group B Streptococcus, Mycobacterium tub
fuenza infections, but successful treatment depends on administering these drugs within the first 48 h of illness. The recent outbreak of av
nformation-dense analyses of these cultures using multiunit extra cellular recordings from microelectrode arrays (MEA) or automated conf
(86 x 128 mm) and are available in 24, 96, 384, or 1536 well configurations. A single experiment or assay is carried out in each well and the
identify head trauma and monitor the progression of the condition. Once the primary impact associated with TBI occurs, rapid response is
ke the most effective use of these advanced synchrotron sources for important protein studies, however, new, efficient, high- throughput d
her irregular across the periodic table and depends on the nuclear structure of the absorber. Unlike X-rays, neutrons can easily penetrate m
Developing biomarkers, which will signal the presence and the type of lesion is a major thrust area in cancer imaging. Special emphasis is o
y Commission reported identifying and taking action to reduce or eliminate the risk of lead poisoning from a number of consumer product
nd expensive to grow, reproducibility is poor, and the material is simply not available for general commercial use. To overcome these drawb
nterest to be labeled in trace amounts and introduced into the body for imaging with PET. The distribution of the tracer is imaged dynamica
l abnormalities, and tumors in live animals. Existing CT systems provide high-resolution images with excellent sensitivity; however, use of th
rough an organ under study in the body. These images allow investigation of metabolism in the region being studied and are a useful tool f
d radiolabeled probes. Unfortunately, precise signal localization can be extremely difficult due to low spatial resolution and the lack of ana
It has been shown that the thermal neutrons are a far better tool for probing interactions between proteins and water, because they inter
ch engine does) in data but instead try to find facts in data. A fact is something claimed in text or a database explicitly. A fact may not be tru

cks such as limited sensitivity, long time of incubation, subjectivity and large amount of reagents. It is in this context that we propose to dev
ti-D for prophylaxis of HDN, (3) qualitative assessment of anti-D preparations, and (4) use in pharmacokinetic studies. Most clinical laborat
will have greater commercial success than an approach that only targets a sole aspect. Excessive consumption of alcohol results in many ch
protein resistant polymer with an antibacterial peptide. The peptide kills bacteria through a multi- tiered mechanism that is fundamentally
cumented. With increased emphasis on early detection of breast cancer, it appears the effort to avoid missing a malignant lesion may have
cle emitting radioisotopes for cancer therapy is emerging as an exciting and potentially powerful new treatment strategy in targeted radioth
etastases. There is no effective therapy for these diseases. Together 199,280 people in the US will be diagnosed this year and 97,070 will di
e rise to high levels of anti-glycan antibodies of all classes that can be used for diagnosis and prognosis. During Phase I of this project, Alpha
eases can enable the discovery of new autoantigens, the development of microarray-based diagnostic assays, and effective treatments for
enes which cause problems for long-term treatment. Knowledge of the spectrum of mutations in HIV-1 genes is extremely important in ord
oximately 56,000 annual deaths caused by CRC. However, current methods for early detection of CRC, which include the fecal occult blood
erve tissue. Currently more than 100,000 Americans suffer from NF1 with the disease having one of the highest prevalence rates for a gene
objective clinical judgments. For prostate cancer (PrCa), the gold standard for pathological diagnosis is cytopathological analysis of biopsy ti
tiplex assay which uses high fidelity PCR for amplification of target mutations and hybridization of Luminex bead-tagged probes for detectio

feedback of voluntary joint torque, while the sensation of motion is enhanced by tendon vibration. In a pre-clinical trial, we showed AMES
high resolution 3-D structural information for these proteins. In this proposal we seek to directly address a formidable general barrier to s
physicians, visitors and patients themselves, respond to these messages by voluntarily increasing their hand hygiene. As a result, nosocom
he possibility of forming carcinogenic nitrosamines. NORTECH is uniquely able to deliver biologically active levels of NO for a sustained per
rgan transplantation is the only clinically effective strategy. Consequently, the field is ripe for translational studies that identify and develop
 nd cellular programs of apoptosis and fibrosis that drive renal disease. Scatter factor/hepatocyte growth factor (SF/HGF), is a renotrophic fa
he lung is exquisitely sensitive to ischemia. Mild to severe ischemia-reperfusion injury is a frequent complication in lung transplant recipien
rest and heightened optimism for the development of new therapeutics for the treatment of human glioma. Receptor tyrosine kinases hav
nd according to research studies, annual direct and indirect costs of scleroderma in the United States are $1.5 billion. Morbidity represents
pulation, have RA. It can affect anyone, including children, but 70% of people with RA are women. Onset usually occurs between 30 and 50
s with SCI face a life-long sentence of extreme morbidity. Hepatocyte growth factor (HGF), also known as Scatter factor (SF), has documente
, and stroke. Cerebral palsy is the most prevalent and one of the three most common physical impairment for children of ages 17 and unde
uirements met principally in necrotic tumor areas. The resulting tumor killing was at best limited since anaerobic bacteria could not grow in
fforts have been greatly facilitated by sub-genomic HCV replicon systems that efficiently replicate in cell culture. However, despite all the be
ge quantities of simple linear peptides, as well as complex, multi-component peptides. Proof of concept will be demonstrated by synthesiz
hown in previous work to detect the onset of AMD at least four years before it is clinically evident. Testing is completely non-invasive and c
spholipase D2 (PLD2). PLD2 normally hydrolyzes cell membrane phospholipids. However, in the presence of a primary alcohol, PLD2 can ca
dence of and mortality from various cancers including prostate cancer, exposure to the sun and cutaneous synthesis of vitamin D. The biolo
mnography, an imperfect gold standard, is not practical to apply on a wide basis. As many as 20% of all children snore, and most sleep labo
development of new drugs for the treatment of ocular diseases associated with excessive angiogenesis. Sphingolipids are being increasing
ve treatments, both of these approaches suffer from major limitations including the inability of insulin therapy to totally prevent diabetes-
tivate them for the generation of an effective anti-tumor immune response with therapeutic efficacy for cancer immunotherapy. Therapeu
is not known, the lack of an adjuvant with potent immunostimulatory capacity, ineffective delivery of TAAs/TSAs into professional antigen
esistance. Our initial research suggests that APMS will be significantly more effective as a vehicle for uptake and delivery of siRNA construc
contrast (referred to herein as Detect-X(tm) technology). Many protein crystallization experiments are of the trial-and-error type, where fre
ive source of reference material and instruction. As part of the online reference material, a drug modeling engine will be available to the u
sinterpreted information. In a one year study of 1024 patients in an ICU, 241 human errors extended the stay in the ICU by 425 patient day
tanil) and a sedative hypnotic (propofol) in human volunteers. The measures for this PkPd interaction model include the probability of loss
w. The final product will be the first commercially available grid-free "virtual MPHV test chamber," which can be used by scientists and hea
ormatics approach, we have successfully engineered a human apyrase, APT102, which exhibits significantly higher enzymatic activity and p
mary graft dysfunction, remains an important problem after lung transplantation, and still represents the single biggest cause of early morb
CO2, octenol, lactic acid etc. baited traps, with or without light) or adult oviposition behaviour (Culex gravid traps, Aedes ovitraps). These t
croarray (5,000+ genes) in sheepshead minnows. We will conduct a number of short and long term exposures on sheepshead minnows usin
n the United States (173,000 estimated new cases diagnosed in 2006) and more than 160,000 people will die of the disease each year mos
eaningful choices about medical alternatives. At the heart of the informed consent doctrine, is the notion that the patient unde

laboratories maintain archives of thousands of such precious samples for years at a time while they pursue better understanding of both c
ogether is becoming a bottleneck in the modern biomedical research and drug discovery process. Efficiency of data search, access, and ana
onically infected by 18 years of life with mucoid forms of Pseudomonas aeruginosa that over-produce the surface polysaccharide alginate.
the brain capillary wall, which forms the blood-brain barrier (BBB) in vivo. Without treatment of the CNS, the young patients are destined t
equipment using efficient and robust techniques borrowed from the semi-conductor industry. They have significant advantages in cost thro
oscopists, establish best practices for performing colonoscopy by quantitative characterization of expert's skill, and enhance colorectal can
MD is the chief cause of severe and irreversible loss of vision in elderly patients. Over the past several years, much progress has been made

ular imaging. In addition to the use of imaging to visually assess tumor growth, a physician may biopsy the tumor to assess the tumor respo
idual with diabetes, sounding an audible alarm to wake the person if an impending hypoglycemic event is detected. The system will be bas
ctive biosensor device capable of detecting and discriminating proteins in human serum samples taken from patients suspected of being ex
nt to benefit when Multipotent Adult Progenitor Cells (MAPC), a pluripotent adult stem cell, are administered intravenously (IV) or intracer
rovided these analgesics do not interfere with the research objectives. Furthermore, the Institutional Animal Care and Use Committee (IAC

nvironmental samples to determine the transmission pathway from the environmental to humans. MU is the causative agent responsible fo
 g 1) an "occlusion effect", an artificial increase in sensitivity to bone-conducted stimuli; 2) poor ambient noise exclusion; 3) high inter-subje
widespread and serious pathogens. Drug-resistant Streptococci, Staphylococci and Pseudomonas strains are quite common. Currently as m
ry system for corticosteroids. The specific aims of this proposal are to: 1, formulate sustained release suspensions of the corticosteroid rim
eans that even frequent drug monitoring cannot eradicate rejection due to sub-therapeutic troughs or toxicity due to higher than necessar
elease formulation for the recently approved anti-Parkinsonian agent apomorphine. Apomorphine is useful in some patients but often requ
osis. In the U.S. alone, 200,000 suffer from this disease. Of these more than 40,000 die annually, equivalent to the number who die from br
significant unmet need for Alzheimer's disease diagnostic tools. The hypothesis of this project is that single photon emission computed tom
ilitate development and clinical evaluation of therapies to preserve or replace beta cells. To date, one of the most exciting emerging techno
ere performed in the US in 2002, totaling more than $10 billion in medical costs. Peripheral nerve injuries are under treated primarily beca
of axons) is a common pathological process that leads to disconnection of neurons from their targets, such as muscles or sensory organs. Pe
fammatory properties of BCG. The central hypothesis of this project is that genetic manipulation of BCG to enhance factors associated with
sical, social and economic sequelae of TBI can persist for the victim's entire life, a burden that is borne by the individual, their family, and b
ssing patient functioning, which are presently based on self-report, clinician observation, patient and family concordance, and "snapshot"
g [2]. Of the approximately 50,000 infants born yearly in the United States with a low birth weight, approximately 85% survive. These infan
pproaches. The KnowPain assessment instrument will be able to provide reliable and valid ratings of pain with significant reduction in both

ing as self-reporters of initial germination events. Considering the unique features of the F- spores in context with existing needs

sing a severe problem for bio-sequence annotation. Specialized hardware implementations of sequence comparison can dramatically acce
a web application developed for older adults. Revisions of the programs are necessary to tailor the programs to a college student populatio
p users learn cognitive and behavioral skills to abstain from drinking, drug use, and other addictive behaviors. SMART Recovery is a non-pro
y builds upon the results of the Phase I feasibility study. The study will further validate and norm immigrant and non-immigrant versions of
artnership between the PI, who with colleagues, developed and evaluated the efficacy of BA, and the small business, Behavioral Tech Resea
e PI's small business concern, Behavioral Tech Research, Inc., a company with an impressive history of developing innovative training progra
inson's disease and Alzheimer's disease. The relatively recent discovery of a family of proteins called "regulator of G protein signaling" (RG
with a chemical gradient - is the fundamental process underlying neutrophil recruitment. Despite its importance, screening tools for high t
put approaches used for early drug discovery. In this proposal we propose to develop and commercialize a Microfuidic Reconstituted Tissu
veloped a murine in vitro pancreatic stem/progenitor colony assay that we are using to identify factors required for beta cell /islet differenti
m objective of Bexion Pharmaceutical Inc's research and development program is to evaluate the clinical benefits of Bexion's proprietary fi

scles lift a weight with a shortening contraction (SC) and then lower the same weight with a lengthening contraction (LC). Recent randomiz
ng a better research tool for studies using pigs. Pigs develop conditions similar to humans (diabetes, cardiovascular disease, hypertension, o

tive reduction of C=C bonds that are conjugated to carbonyl groups has been a particular problem, as over-reduction leading to partial redu
1 cm distance in about 1 minute. Using a table-mounted version of this new imager in Phase I of this project, we have revealed for the first
ecision placement/monitoring of diagnostic/therapeutic probes. Breast MRI, while extremely effective in detecting cancers, has yet to prod
aningful discoveries. As a result, the vast bulk of data collected through bioscience research are not standardized and cannot be integrated
dermal growth factor receptor (EGFR) have been shown to increase resistance to chemotherapy, thus increasing the risk of metastases. Bio
mase/helicase, a DNA polymerase, a single- stranded DNA binding protein, and several other accessory proteins. As such, bringing this nove
s or other complex apparatus, resulting in a single-pass, tangential-fow ultrafiltration method. The specific aims of the project are: 1. Des
) technology is a tool that can aid in understanding the physiological and metabolic properties of fastidious pathogens. It enables a scientis
chest x-ray, chest CT scan) are not possible for emergency squads or battlefield medics and not practical for long-term monitoring of critica
a and reperfusion injury. Re- initiation of blood fow causes activation of several infammatory mediators of the cytokine type, selectins and
ng; but, currently, all existing haemostatic agents for abdominal intracavitary bleeding are designed to be used in the operating room--not in
ure assessment research, spatio-temporally varying datasets, such as daily activity spaces, residential histories, and time-varying maps of en
entification of scales of variability, spatial interpolation of individual-level data to create isopleth maps of relative risk, identification of clust
 encies of geographic studies of cancer are that they lack an appropriate methodology for investigating clusters over the life course and risk
uous measurement and transmission of these IOP readings to a remote receiver. Current technology does not allow for real-time, continuo
olecule analysis of large native state genomic material. The anticipated embodiment will permit direct visualization and analysis of chromo
Increased availability of quality anti-peptide polyclonal antibodies would greatly benefit proteomic research. Unfortunately the production
multiple organ systems including musculoskeletal, skin and nervous system and is included in the differential diagnosis of multiple diseases
m infected wildlife reservoirs and transmit it to other uninfected wildlife. At present, there are no effective measures to control B. burgdorfe
and 2010. These increases in CKD and ESRD are associated with significant morbidity, mortality and healthcare costs. Early detection and tr
ST) is a label material designed to be assayed by a number of measurement technologies and able to be readily taken up by cells. IVST is be
ocedure. In the United States alone, an estimated 3.3 million diagnostic x-ray angiograms are performed annually at a cost to the healthcar
ects of increased TNF expression in infammatory diseases can be readily evidenced by the success of TNF inhibitors to treat diseases inclu
reat need for inventing efficacious therapeutic drugs to treat patients with sepsis associated illnesses. Increasing evidence indicates that ab
or ophthalmic imaging, which uses low-coherence interferometry to obtain cross-sectional images in living tissues with micron-scale resolu
nize HIV monitoring and infant diagnosis in the resource-scarce regions most impacted by HIV disease, helping to narrow the health care qu
the technology for the rapid metabolic engineering of E. coli for the production of pharmaceutically active polyketide natural products. The
chemiluminescent substrates to give highly amplified signals. Certain enzyme / substrate combinations allow detection of gene expression
onnector to avoid inductive noise pickup from movements, other people and signal transmission through changing ambient electrical field
the important ability to generate customized speech that mimics aspects of the user's past or intermittently available speech. Modern "con
and are increasing in incidence. We have found that the diversity of the mucosa associated or luminal wall adherent microbial populations

compared to white Americans. Traditional means of reaching African Americans with health messages has had limited success largely due t
lizers for the delivery of microgram quantities of many small molecules, efficient and effective aerosol delivery of many of the above agent
ition to microbial identification for clinical response, diagnostics are also needed for a wide range of applications including food and water
he seventh leading cause of death. Research indicates that these long-term complications can be minimized in diabetics if blood glucose le
ase substrates for detecting caspase activation in live cells and animals. By utilizing Biotium's patented technology, we created a novel clas
While the drug discovery industry has embraced this new technology, the enthusiasm has been tempered by the modest success rates of the
ally acceptable packaging will consist of a miniature camera and visual display discreetly mounted on spectacles or a hat, and a compact co
t affects these patients. TSA is a difficult surgical procedure, which requires accurate placement of prostheses through a small, deep incisio
being investigated in human clinical trials include idiopathic pulmonary fibrosis, liver fibrosis, hepatitis C and ovarian cancer. Interferon-gam
o the invading pannus. This formation of new blood vessels (also known as angiogenesis) is a highly regulated process under the infuence
or design and manufacturing processes demonstrated in Phase I research will be used as a foundation for these MEMS-DMs, which will be p
, cancer, age >70 years, prolonged hospitalization, hemodialysis, connective tissue and infectious diseases. In patients with these condition
her percutaneous devices that provide a support surface for organisms to track into deeper tissue. A typical infection can cost as much as $
anti-microbial strategies used to treat Dental caries have consisted primarily of mechanical removal of Dental plaque or generalized killing

w proteomics technology involving a novel X- ray translucent fow cell design. If our aims are achieved, more accurate, sensitive, and afforda
tional Laboratory. RPM allows the identification and measurement of BRES consisting of protein-metal adducts and metabolites. We propos
M Adherence Biomarkers (CABs) using our unique, national award winning XRpro technology. Caldera, in collaboration with Los Alamos Nati
rrently approved for the treatment of ALS and only extends the survival of ALS patients by 2-3 months. The lack of therapeutics for ALS tre
ndings from our studies and others indicate that this broadly distributed and highly stable protein may be neuroprotective in response to ce

timated that over 2,000,000 deaths occur worldwide every year due to dehydration-associated causes. Currently, no effective means exist to

or cells (CPCs), to promote more effective regenerative growth in human heart disease. Ultimately, the goal is to improve patient morbidity
 xorubicin safety and efficacy in non-Hodgkin's lymphoma treatment. Doxorubicin (adriamycin) is a proven effective chemotherapeutic age
ect regional metabolism and the balance of local tissue oxygen supply/demand. Therefore, an accurate cerebral oximeter would have a wid
e Brief Alcohol Screening and Intervention for College Students (BASICS) is notable for randomized controlled trials demonstrating its efficac
deficits in AD transgenic mouse models. Our recent study demonstrated amelioration of AD-like pathology in PSAPP (APPswe, PSEN1dE9)
with this protocol. The ultimate objective of this proposal is focused on the identification and expansion of progenitor cells from adult panc
ssors. Recently, we have recognized that it is not adequate to merely address stress response issues during isolated events of cell processin
mic storage (4C) and cryopreservation (-196) so that improved preservation solutions can be formulated. These solutions, sold by CPSI's ma
mic storage (4C) and cryopreservation (-196) so that improved processes can be developed. Similar data on stress pathways are also being
hosphorylated peptides in bulk, there is no bulk purification technology for acetylated peptides. The long-term goal of this project is to dev

ed information from thousands of published reports about specific phosphorylation sites, how they are physiologically regulated, and the b
he Critical Path Initiatives by the FDA to provide additional pre-clinical drug screening tools other than animal models. The value of this pro
marily due to the limited choice of suitable toolsets to rapidly delineate potential drug targets and screen new drugs en masse. Phage displa
arily due to the absence of suitable toolsets to rapidly delineate gene function en masse. RNA interference (RNAi) has proven to be an extr
marily due to the absence of reliable experimental and bioinformatic toolsets to rapidly delineate and describe gene function en masse. RNA
ointestinal tract (GI) and hematopoietic system are serious sequelae of radiation exposure for which there are few effective post-exposure
led with this polymer is its use for purification of fu virus during fu vaccine manufacturing, particularly for fu virus derived from cultured c
ally being made available to developing countries through charitable organizations and pharmaceutical companies. For it to be effective, ho
c safety studies prior to drug approval. Since compound development costs a drug company approximately $45,000 per day, identifying can
e as many as 7,000 deaths reported annually in the United States from incorrect prescriptions. To address this problem, Centice proposes t
handheld, diagnostic immunoassay system. In this grant proposal, as just one illustration of a multiplexed and quantitative rapid test platfo
urely electronic process. Two dimensional arrays are necessary for this achievement, though there are significant challenges to fabrication
ent placement and stent monitoring, and has advantages over other modalities in that it is capable of distinguishing various tissue types. A
itic activities. These new activities, unique to the C6-glycosylated macrolides, are proposed to derive from their ability to cause anomalous
veloped from such natural products. A major need in the development of a cancer drug lead will be to maximize the difference between in
ncreases at more remote donor sites are not procured due to justified concerns about post-mortem ischemia during transport to the islet
ess expensive than current CBC instrumentation, which is based on multi-channel, multi-detector fow systems. A simple glass disposable sl
l and physiological processes. ED effects (e.g. estrogenic or anti-estrogenic) sometimes occur at very low (picomolar to nanomolar) concent
vitreous cavity hemorrhage and/or retinal detachment, leading to severe loss of vision. Vascular endothelial growth factor (VEGF) plays a p
ular endothelial growth factor (VEGF) in the retina is a major causative factor for vascular leakage in DR (2-4). Currently, there is no satisfact
Although the pathogenesis of DR is uncertain, over-expression of vascular endothelial growth factor (VEGF) is believed to play a critical rol
where it has caused extensive outbreaks associated with fooding and fresh water recreation. In less developed countries, leptospirosis is a
profiling of cancers, which can guide health workers towards a more patient-specific, accurate, and more successful treatment. The majorit
o ACC isozymes in humans, with very similar amino acid sequences, differing mainly by a 200-residue N-terminal extension on ACC2 that di
eparation technologies for the removal of arsenic from drinking water. Conventional adsorbent technologies currently in use for remediatio
m care of the prematurely delivered infants. Currently used diagnostic tests cannot accurately screen for the risk of preterm delivery in asym
munities confronting malignancy, as well as the clinicians who treat these patients. TEACH is based on a virtual environment that gives prov
based bioassay platform that specifically captures distinct cell types and soluble macromolecules from a patient's blood sample onto spatia
elated diseases consist almost exclusively of single marker tests. There is a well-recognized but unmet need for improved diagnostics based
central role in the attack on insulin producing islet cells. For medical intervention for T1D to be most effective, the disease should be detect

s based on a simple idea but requires an innovative and unique mechanical structure to make it effective, easy to use and manufacturable.
motor features, sense of smell, sleep parameters, voice modulation, and other relevant neurological signs. The system will aid in PD screenin
electively (by specific transport mechanisms) excludes most blood-borne substances and xenobiotics from entering the brain, protecting it
struggle to care for their loved ones. SOLUTION: In response to the National Institute on Aging PA-06-049 (previously PA-04-064), we propo
 re the first to interact with these youth, the assessment of psychiatric issues in young patients should be a high priority for programs educa
ents with schizophrenia. Amelioration of cognitive deficits associated with schizophrenia represents an important clinical target for drug de
amyloid angiopathy (CAA), is also commonly found in AD. Additionally, several familial monogenic forms of CAA exist that result from mutati
r rodentium (C. rodentium) model, an acute Dextran Sulfate Sodium (DSS) model and a chronic DSS model of colitis. We will also define wh
ptoms of PD are caused by the destruction of dopaminergic neurons in the substantia nigra, leading to a severe reduction in dopamine conc
tics to treat sepsis have been disappointing with only one drug being approved. Recent evidence has implicated apolipoprotein E polymorp
tments. This lack of response may be due, in part, to the current therapeutics being specifically targeted to the infammatory phase of the
d to existing therapies generating a critically unmet medical need. The ultimate goal of this study is to develop a novel therapeutic drug for
using screws and pins, and complication rates due to intra-articular misalignment and non-unions is as high as 62% (Weber 1986). Bone adh
maintaining tissues in position for natural healing to occur. Seroma formation is among the most common post-surgical complications, occur
6 months. A lag time of 6 months between identification of a pandemic strain and an adequate supply of vaccine could result in devastating
h and therefore reduces their educational and job opportunities. ESL learners compensate for their impaired phonetic perceptual skills (bott

of reviewers, was shown to be excellent and far superior to other commercial membranes. CMS membranes were shown to be stable up to

stprandial state. We have recently demonstrated that puerarin, the major isofavone C-glucoside found in kudzu dietary supplements signifi

t of cochlear implants (CIs). The need for such protocols and instruments is increased by the recent advent of bilateral CIs, since the assessm
species present in the exhaled breath of a human being. This instrument will employ a novel atmospheric pressure "supersonic pulsed ion
n in health care costs per year (Report of the Commission on Evaluation of Pain, 1986). In addition to physical morbidity and cost issues, psy
kle the computationally more demanding mPBE. In Phase I, a preliminary version of the mPBE solver will be developed and tested for biom
uperior strength and stability. Millions of ophthalmic procedures are performed annually, most incorporating sutures to close and seal wou
he palpebral conjunctiva is an excellent access point to measure hemoglobin and other blood constituents when analyzed quantitatively u
enign tumors of the mandible may also require segmental bone resection due to high incidence of local recurrence after simple curettage

ination of gerontological research." Traditional, fixed-form outcome instruments present serious measurement and practical requirements
vice that will help clients and caregivers transfer more easily from wheelchair to bed to toilet to bathtub. Currently available commercial lift
ween providers and pay higher portions of the total healthcare bill out of their pocket. Medicare, state governments, insurers and several
0 recumbent cross trainer, which provides a coupled reciprocal leg/arm extension exercise movement against graded loads while the subje

f methemoglobin lead to tissue hypoxia and even death. Methemo-globinemia is commonly caused by environmental or work-related chem

rldwide GMP manufacturing capacity for these therapeutic proteins, and approaches for getting more protein from the available bioreactor

ively complicated revision surgeries. The goal of this Phase I STTR is to develop an implant suitable for complete resurfacing of an osteoarth
mmune therapy. We specifically propose to apply HTS for the identification of agents that enhance cytotoxicity against melanomas, by augm
anglia (DRG). We have identified that CYP4X1 converts arachidonic acid (AA) to the four regioisomers of epoxyeicosatrienoic acids (EETs). M
th many forms of cell therapy, one of the limiting factors is the availability of an accessible source of autologous cells capable of providing
ar magnetic resonance (NMR) spectroscopy continues to be a central technique in the characterization of the structure and dynamics of pr
me and/or High-Functioning Autism (AS/HFA). STRIVE will be an innovative, skill-building resource designed specifically for late adolescents
n diverse treatment settings. The product's overarching goal is to help reduce relapse and sustain recovery by improving client confict resol
vior; pleasure, gratification, or relief when pulling out hair; and clinically significant distress or impairment in social, occupational, or other
d children and their families in treatment. Recent consensus reports conclude that undertreatment of children constitutes a public health c

ms related to alcohol or other substances, and their families. In 2002, only 8.2 percent of the estimated 2.3 million youth who needed addic
reatment intervention. Such data could be very complex when there are multiple levels of data structures. The data might have factors such

has shown improved survival, from a median life expectancy of 5 years in 1960, to 16 years in 1970, to 35 years today. Yet, the disease rem
e Personality Disorder educational video series will provide family members with an overview of BPD, current research on BPD treatments
de them with information to make safe and healthy decisions. The goal of the curriculum is to educate girls and boys about general and gen
growing cancers that characteristically out grow their blood supply. Preliminary in vitro and in vivo studies are presented to support docum

Web DVD technology. AIMS: Translate current evidence based research on sleep disturbances among dementia patients into a comprehen
pment. Great challenges and opportunities exist in characterizing and managing the economic, environmental and human impacts of such
much smaller incisions than traditional periodontal surgery, has a record of clinical regeneration of lost tissue, results in less patient trauma
f alcohol regarding the medical and legal risks of providing and consuming alcohol. This population is accessible through alcoholic beverage
t girls and young women. Twenty percent of people suffering from eating disorders will die prematurely from complications. Early diagnosi
rsed chloroquines" (RCQs) which act against both chloroquine-resistant and chloroquine-sensitive malaria. Herein we describe a new sub-c
he National Health and Retirement Survey (HRS) and ties them to a unique segmentation system that classifies the nation's older populatio
s especially those that process less than 10,000 donations per year and are located in regions of high prevalence for HBV. This simple and in
new biomarkers will be very important for much-needed advances in screening, diagnosis, prognosis, prediction of disease recurrence and
logy, notably DCP can identify the protein differences between two body fuid or tissue samples and simultaneously generate an affinity re
er the system can engage a user and affect adherence over a three month period. The prototype will be designed based on usability testing
depression and deliver that automated assessment remotely over telecommunications or internet infrastructure. The value of the system i
opose to develop a novel technology that will allow for the discovery of highly selective protein kinase drugs targeted to the allosteric regul
harmaceutical industry to develop drugs targeting growth factor receptors. In this grant, we propose to develop a novel technology that ca
fic cell types following systemic injection by coupling a targeting tether to the plasmid carrier of the transposon. This approach will allow 'un
ant. However, most patients lack a matched related donor, and there is a marked increase in morbidity and mortality following transplant u

e non-monetary costs, in terms of social and physical disability and general quality of life, cannot be easily quantified. This proposal describ
nomic burden within affected areas and is ranked as the second leading cause of long-term disability. In 2000, international groups includin
(TMA), and cytology glass slides for clinical and research purposes. This optical system will allow scanning a microscope slide in a single swe
requirement, probes and primers used in an assay must be both highly sensitive and highly specific. That is, they must have a very high pro
plish this, therapists make use of treatment-planning computers to predict the detailed distribution of radiation dose. There is a need for an
of pre-clinical, single- organ, MRS applications, both single-resonance and double-resonance, at fields at least up to 600 MHz, from the use
nced the effectiveness of solids NMR methods incorporating Magic Angle sample Spinning (MAS), and considerable additional progress in s
logies. Proposed devices used for NMR sample preparation and storage will a) improve long-term storage of samples b) alleviate the need
replacing film-based or scintillator-based systems. The dose efficiency of current scintillator-CCD or - CMOS photodiode array x-ray detecto
tic capabilities. We will develop a novel detector module which adds several new important features compared with the basic principles of

or stroke and adverse outcomes. The phase I goals are: 1) To develop and optimize the multimodal pressure fow (MMPF) method, a new a
dify both the E. coli strains engineered to produce polyketides and non-ribosomal peptides, and our BAC vector in which libraries are const
optical-quality surfaces, ultra- precisely remove materials, and fabricate microstructures and microdevices with sub-nanometer level surfa
owth patterns, efficacy of nutritional and medical interventions, progression of chronic disease, and recovery from malnutrition. The collec
ch is still the primary diagnostic method. This is because the usual signs of infection are masked by infammation or the patients' underlyin

by mycotoxicoses related to crops contaminated with fungi, and the safety of the food supply is integral to our national health and security
disease. In addition to pain, discomfort, and tooth and oral bone damage, periodontal disease has been associated with an increased risk o
ties. SLPI protein is found naturally in saliva and elsewhere in the human body. Individuals with high levels of this protein have notably redu
systems that are commonly used yield insoluble or soluble misfolded proteins. We have developed a new folding process that employs a co
re programs will be designed to teach common prefixes, suffixes, and words parts; two research-validated vocabulary learning strategies; a
 ensitivity improvement in measurement of the pore blocking current. A second key innovation is to separate the means used to induce the
some drugs on ion channels have the potential to cause lethal reactions within the body. The entire biology, molecular biology, and bioph
EDVOTEK, the applicant organization believes the opportunity provided by this market is significant and will continue to grow; it affords a un
ential for detect other exposures as well. The sensor is based on Surface-Enhanced Raman Spectroscopy (SERS), which allows precise dete
eric membrane. We propose that a microarray may be constructed using these membranes in which isolated groups of nanotubes are fabr

2D cardiac MRI images to a 3D myocardial viability map, the Percent Infarct Map (PIM) with a voxel-by-voxel resolution. In ultimate human
ged to be important for later retrieval and review. The "experience buffers" described provide an alternative for recording that allows educ
tified in eMetagen Corporation's large-insert soil metagenomic libraries. The project is a collaboration between eMetagen, an innovative b
f the dialysis population is declining as increasingly sicker patients undergo the very invasive procedure. In response ETC proposes to develo
spread consensus that it is important to realize a greater return on our prevention research investment by developing effective ways to use
ce allocation. Although states, counties, and municipalities gather an abundance of data relevant to prevention planners, existing analysis a
ugh their speech, in the manner of people with normal vocal capabilities. VG uses an innovative approach to detect icons in a text string an
e no readily available, cost efficient, intraoperative instruments that ensure that the cancer has been completely excised to prevent re-excis
bsequent precipitation of an organic solvent dissolved polymeric materials injected into a malformed vascular bed leading to its obliteratio
tally, are also treated. Endovascular therapy has recently evolved as a minimally invasive treatment for cerebral aneurysms and is slowly be
equired (compared to electron microscopy) allows tomographic investigation of subcellular structures in three dimensions. Existing synchro

data recording and/or transmitting equipment and a position-monitoring device (such as a GPS unit) to provide time- and space-resolved m
at reasonable cost. The long term vision for this technology is that it will become a key environmental science tool to support the developm

t its activity as it functions naturally or under the infuence of drugs of abuse, and with various color-contrast views to illustrate changes in
ed in the presence of human Rh proteins. The goal of this project is to create strains of mice expressing human RH transgenes and use them

al pulmonary function tests (spirometry) are often not adequate to provide the respiratory functional information required by health care p
quate quantities of tissue for experimental work, produce sufficient amount of antibody or therapeutic proteins, and yet it is small enough
tic therapy with t-PA or streptokinase. Plasmin-induced activation of the intrinsic coagulation system, proceeding via two tightly- linked enz
nd hybridomas, achieving a specificity (quality) threshold that is markedly higher than is feasible for other antibody screening technologies
highly concentrated nanopolyplexes. High grade gliomas represent the most common form of primary malignant tumors of the adult cent
a decrease of both volume and quality of tear secretion. There are currently no approved topical agents for enhancement of tear secretion
elucidating the significance of cancer-associated splice variants is the lack of a systematic technology that can reliably detect and quantitate
nly barrier to routine CD4+ monitoring in resource poor settings. Personnel need to be trained to use relatively complex equipment (cytom
nt since 1997, when our immunoinformatics tools were first applied to identify T cell epitopes from TB proteins. In progress made during th
to Factor VIII (FVIII) is its most significant complication: immunogenicity not only reduces or eliminates the therapeutic efficacy, but also re
provide a novel and rapid separation technique for chiral compounds. Similar to chiral chromatography and capillary electrophoresis, the ab
y ethanol with great specificity, but also a number of other compounds that appear in breath. Therefore, the overall goal of the present gra
for "Development of information, instruments or methodologies to improve and/or track adherence to complex HIV/AIDS drug therapies fo
ch foam cells that can form artery clogging obstructions. In addition, sudden and unexpected rupture of these plaques can lead to sudden
the novel compounds in cell-based assays is essential during preclinical investigation. However, the lack of specific physiological substrates
nd cancer-related defects (e.g. mastectomy, parotidectomy). There are currently many approaches to soft tissue reconstruction, enhancem

logical inhibition of FAS leads to apoptosis of human cancer cells in vitro and in vivo. FAS is the enzyme which catalyzes the de novo synthe
erest to this study are the actinomycetes, a group of soil bacteria that are best known for their ability to produce over two thirds of the wor
re to identify key enzymes and metabolic pathways either known or predicted to affect carbon fow at the methylmalonyl-CoA node and m
irubin encephalopathy in newborns, contributing to the uncertainty in the management of jaundiced infants. To address this problem, a ne
time. Diabetic foot ulceration (DFU) represents a major problem that can significantly impair the patient's quality of life, require prolonged
created primer to primes the synthesis of a strand of DNA complementary to the target. The selectivity of the process is such that a single D
larly in urban areas. Human derived PM tends to be of smaller size, facilitating entry into the body through the respiratory and digestive tra

S. military can be adapted for use by nurses to communicate effectively with their non-English-speaking patients. For Phase I, Sehda will cre
ssue. Histology is slow, cumbersome, and destructive because it requires first sectioning the tissue, then staining it. In addition, the quantit
ect arraying of fuorous-tagged compounds based on technology developed and patented by Iowa State University. Based on the success o
research as well as in drug discovery. The goal for this Phase II project is to continue to further develop a versatile drug-screening bench-to
Addressing threats to school success in adolescence is imperative, as is working with elementary school children to prevent the developme
coma patients delays the development of vision loss (Palmberg, 2002). Even glaucoma patients with IOPs in the normal range benefit from
employing this strategy. It is imperative that new therapeutic modalities be developed. Another approach to take is to develop drugs agains
amplifiers in RoHS compliance for the medical systems industry in MRI. One of the fastest growing clinical applications in this powerful med
th, enhancing sexual function, and improving mood. Androgens are also being considered as a treatment for rheumatoid arthritis, wound h
ovel mechanism of action is the blockade of transporters for the neurotransmitters norepinephrine (NET), serotonin (SERT), and dopamine
oposed program is an environment, called CORSA, that integrates correlation techniques with models of cyber-missions and the associated
ore it becomes a practical reality. AMM theory has only recently been cast in a usable form, by Norris (“Acoustic Cloaking Theory,” Proceed
essing whether or not the weapon reached its target. In Phase II, we propose to refine and validate this concept with a combination of num
Toolkits will be based on PZFlex, a finite element simulation package heavily used in the ultrasound and SONAR communities, leveraging de
or effective continued development of the technology, along with further fuel savings in addition to the economy offered by the PDE techn
onents digitize a wideband RF input signal and the room-temperature TIPS analyzes the digitized signal stream to generate signal signature
model capable of predicting damage from internal detonations incurred by a wide variety structural components, materials and constructio
aptive signal processing to suppress jamming signals and other interference sources; and 4) powerful error correction decoding. The wavef
that will be common in future air, sea and ground combat systems. This system can incorporate a variety of multicast key distribution tech
fatigue in the precise areas where they are needed. New oil formulations are proposed for run-in with lower friction and for emergency o
scence based on local environmental data, in situ measurements, and simple radiative transfer models. Our envisioned BRDA will include 1
ipped with a 17-angle volume scattering function device called the MASCOT, specifically modified for this application. Optical data will be in
orporates a modular approach to the electronics processing and communications, allowing multiple deployment opportunities for unobtru
allenging problem that the traditional inter-domain networking based upon BGP/TCP connectivity cannot address. Of interest in this SBIR i
al safety issues that were not forecast can also be encountered. Recent studies by both U.S. and NATO organizations have identified structu
ed with other like temperature sensors in an annular ring around the combustor to determine pattern factor to sense the uniformity of com
ng, aperture resource management, array calibration, and adaptive pattern control for interference suppression. During the Phase I effort,

tive hosts, are opportunistically leaking information without detection, or they lay dormant awaiting activation. Once activated, these tech
nd highly reliable features already inherent in the fundamental igniter design. Modeling and simulation efforts relating to this igniter will b
use commercial-off-the-shelf IEEE 802.15.4 wireless transceiver modules to demonstrate the wireless feature of our fire detectors. 802.15
pose to optimize our existing software-defined radio architecture and develop an Embeddable, Power Efficient, Robust, and Reconfigurable
port equipment. In order to minimize fuel consumption while providing power for these and future systems, the DoD needs a tactical powe
exorbitant, requiring expensive camera systems and personnel to weed out false alarms. In response to these needs, Williams-Pyro, Inc., p

ted over broadband and narrowband portions of the 10 MHz to 30 GHz frequency range. Consideration will be given to these configuratio
omponents derived from technological advances are easily integrated. For time-critical, real-time functionality, dedicated hardware is recom
c impulse approximately 265 seconds for the smaller sizes and 280 seconds for the larger sizes where the injector geometry is more favora
ation of using desensitized nitromethane for better storage and handling properties, along with a new, small and light spark igniter, and jus
l aircraft, heat input at these levels can result in unacceptable fuel temperature rise, leading to undesirable performance tradeoffs. In this P
lysis Tool is to assist SDR waveform and platform developers (as well as those responsible for certification of SDRs) in the evaluation and qu
artnership to enable reliable, rapid access, low cost demonstrations of ORS technologies. XCOR is developing, using already-secured private
sive virtual environment and multiple users’ view can be synchronized so they are immersed in the same virtual environment. It will be com
cepts to specific implementations. It will provide BMDS the ability to integrate computer systems, components and applications to perform
and certification as executable models to produce high fidelity, repeatable and readily communicated artifacts. We propose an innovative a
process represents a significant contributor to the life cycle cost structure. The WW Technology Group proposes an innovative solution to
/FPGA, low power ARM processors, solid state disk arrays, and proven hyperspectral band reduction software. The hyperspectral imager is
Reuse Planning Tool, and • to provide the preliminary design for the Reuse Planning Tool. As a first step for the development of a compreh
enerated traffic and the transmission capacity of potential SATCOM systems based on the scenarios given by the user. The tool will allow th
ages have sufficient contrast ratios. That is, the sun must be located behind the observer’s camera and it must be daytime. Although the fir
erical Weather Prediction (NWP) models, particularly in littoral regions near large population centers, hinge heavily upon accurate initial co
ng potential algorithms • to demonstrate analysis findings using simulation and provide recommendations The primary analysis simulation
mance at elevated temperatures. YTP proposes to take the innovations and concepts in this proposal (cathode type, stabilized electrolyte, b
g device will maximize the use of recent advances in commercial-off-the-shelf (COTS) Micro-Electro-Mechanical Systems (MEMS) technolo
m mainstream suppliers, and our deep knowledge of real-time systems. Yotta’s modular, extensible approach will bring consistently reliable
d utilized within a three-dimensional fate-and-transport finite-element model to resolve and identify the source(s) of TCE. Initially, ZAPATAE
meet the 18 inch x 18 inch x 4 inch objective.
mercial printing. These cavities are available in size ranges from less than 10 micrometers to over 100 micrometers. A thin sheet of nano-s
e passband and the stopband.
ducts that fall in cosite receiver channels.
afe system. Further, olivines are resistant to overcharge and thermal degradation, and are inherently safer than oxides that may release oxy
each direction-finding receiver channel.
lightweight batteries used in aerospace applications. We also research, develop, and sell high energy density metal-air cells. Yardney will a
surface roughness, large-scale ocean surface currents as weak as a few cm/sec can be detected with existing orbiting scatterometers. Durin
ed oxygen diffusion rate, are incorporated into the cells. Several areas to optimize the cells have been identified and will be investigated. Th

me detection at 10 meters better than 1,000. Explosives and related compounds (ERCs) feature broad spectral signatures that are separable
: • Represents a breakthrough in realization of a robust and precise pump/valve via a new 3D molding process using precision lithographic
The Cartesian grid/ boundary condition features of CartEuler allows it to perform rapid but accurate nonlinear aeroelastic simulation for c
g nonlinear structures, computational aerodynamics, ROM methodology for wings in morphing with large amplitude motions. The promisin
ve a go or not go answer for a class of airplane. In order to realize this goal we have deeply analyzed those big RWDs and found that there
ascade lasers (QCL) that operate in the terahertz region of the electromagnetic spectrum, a region rich in molecular signatures but under-u
digital battlefield. The higher cell capacity simply means the longer running time for some devises or longer range for some weapon, whic
no-anode materials provides exceptionally high-rate capability (>95% of rated capacity at 10 A continuous discharging) and allow conventio
es. A unique combination of material composition and permanent magnet (PM) size and spacing allowed for the peak force per unit length
nary tool for materials assessment during HgCdTe FPA processing and production. In particular, when the ‘deuterium decoration’ process is
prene glove are inadequate for protecting the diver and enabling his mission. These gloves have poor thermal performance, are bulky, buo

board test set enables a new testing paradigm whereby parametric field studies are performed prior to the optics specification and electro
mbinational and sequential digital, analog, and mixed signal design architectures including full custom, semi custom, standard cell, and prog
ish between parts of a scene that appear indistinguishable under intensity-only imaging. Finally, we have illustrated the development of a
to proceed at its optimum speed. The quality of the decoating process will thereby be greatly improved while throughput of the laser deco
he development of the heater are in the areas of catalysis, fuel addition, and mixing. Use of a highly active, stable catalyst will allow clean o
The proposed work will detail the design concepts, establish the Concept of Operations, create a real-time, first person simulation of the ta
ve dark currents. Such defects in HgCdTe FPAs must be addressed for Next Generation detectors to deliver on their promise of better discri
ed reactant conversion relative to the unsupported hydride will be achieved. The low decomposition temperature and high hydrogen gravi
motion through the visual, proprioceptive (‘seat of the pants’) and vestibular systems. Realizing that the large-scale proprioceptive inputs re
s to develop new broadband noise abatement materials that could be retrofitted to the EFV to counteract airfow generated noise. Phase I
putee, including decreased comfort, increased shear forces, increased pressure on bony prominences, as well as a poor gait pattern. An unc
x has already demonstrated its nanocomposite elastomer boot material’s ability to withstand the full battery of sand and rain erosion tests
100% compliance is often not achievable in the battlefield due to several complicating factors. Essential to soldier heath is the rapid deplo
Infoscitex team is developing a methodology for establishing measurement techniques to determine the physical and cognitive effects of lo
on military operations in terms of transportation and storage. In this Phase I SBIR program, Infoscitex Corporation (IST) and Cascade Design
immunohistochemistry. The ante mortem diagnosis of prion disease is complicated due to very low concentration of PrPsc and high prese
on and supplying distinct identification of individual materials and material lots. In this Phase I SBIR proposal, Infoscitex proposes the use o
we propose a novel scheme that addresses the problem of combating DoS attacks by raising an early alert. We employ a simple method tha
onnel are in considerable need of advanced hearing protection, which necessarily would provide protection beyond this bone conduction
motion, provides adaptable support and optimal energy attenuation to each individual occupant. (d) An extensible five-point harness belt
lass adhesives. As the power systems have become more advanced, the limits of Dow Corning’s DC93-500 have been exceeded. Infoscitex
analysis. In particular, we will develop the technology for automatically finding online raster maps, automatically aligning the raster maps
(MTI) is generated based on a rapidly-formed range-azimuth image of the interrogated scene. To improve the system sensitivity to detect s
EMI shielding. There are also secondary weight advantages due to the elimination of electrical wiring clamps and the associated fastener h
 tion of high affinity and selective aptamers after only one round. The ongoing Phase I program has demonstrated the approach to be rapid
e at a low areal density, while enabling designs that are amenable to high volume airfow. The manufacturability of the armor system will le
with a weight goal of < 10-lbs. The target system provides 360-deg Az coverage by 60-deg El coverage, with up to 20-GHz bandwidth in th
efficient of friction and step height. In Phase II we will more fully develop the statistical prediction methodology, including extensions, optim
etween promptness of results from various test groups performing this data analysis, and sometimes even between the values of the inform
cular mission profiles would be invaluable for providing safer mission route planning. In considering this problem, Infoscitex applied the Ph
e concomitant physical impairments. In this Phase II program, Infoscitex will continue to develop the robust and noninvasive volume sensin
R program, Infoscitex Corporation (IST) proposes the continued development of an anti-tamper (AT) solution that promises to bridge capab
als are caused whenever a subject moves their head in a direction other than that of the spinning centrifuge. We have developed a vestibu
tios. This coating protects metal engine components against sand-particle abrasion, corrosion, and thermal fuctuations in extreme conditio
s. Initial projections indicate that a propulsion system based on these materials is also feasible. In the Phase II base program, additional re
vel biomimetic sensor that can be used to calibrate, on the fy, standard sensors to within an accuracy of 1 degree. During the Phase I prog
(MCAG) within Naval Expeditionary Combat Command (NECC). Each of these force elements is uniquely positioned to collect ethnographi
hes to improve the cycle life, reliability, and safety of the Lithium-oxygen battery, both in an oxygen atmosphere and in an “air breathing” m
uate active responsive thin film materials for threat reduction. The active response will reduce damage at the initial attack site and effectiv
evacuation personnel operating at night use a head harness to mount their NVGs in lieu of a helmet, as do ground troops driving or naviga
heat sink to be integrated with a solid state thermoelectric module to generate energy from waste heat sources. This energy can be utilize
base plate heat sinks for advanced GaN based phased array radar systems. The material system will be fully characterized. FEA thermal m
the unmodified drugs in reducing the activity of pain sensory nerves. Interestingly, preliminary analysis of in vitro primary human osteobla

de at tonnage scales for demanding applications such as Electronics. The proposed SBIR project will be executed by experienced metallic f
ermoelectric materials, it now appears that a significant portion of the waste heat produced by an SOFC system can be converted into usea
at tonnage scales for demanding applications such as electronics. Phase I demonstrated metallic fake species with mass extinction coeffici

bility of achieving low voltage (e.g. 100GHz operation at 1550nm. Our proposed approach utilizes 1) PhC waveguides to take advantage of t
or failing. Data fusion of vibration and ODM sensor data has been shown to improve the statistical performance of bearing and gear fault d
monstrated a two-step nucleic acid production method. The first step is the efficient retention and selective concentration of biomaterials
health; it is expected that real-time engine control functions should be possible. Real-time models running on-board to support Full Author
ower, and thrust. The thrust is produced by the rapid acceleration of a compact toroidal plasmoid generated by a non-inductive technique
program. Each device exploits a fundamentally different optical limiting mechanism in organic and polymeric materials, namely nonlinear
ecent developments in SWIR digital FPA technology, and combine that with current LWIR micro-bolometer advances, a programmable ima
risks of harmful fallout from intercepting potential WMD threats near host nations or in allied airspace. This SBIR effort will focus on WMD
electrical faults from mechanical faults. The IAC-1034, the predecessor to the IAC-1044, is already being used to monitor the health of som
ated for insertion into the JTRS HMS SDR program of record upon successful demonstration. It will simultaneously enable order of magnitu
Metal Arc Welding (GMAW) for IBR weld repair. This project will build upon the successful Phase I work by first developing welding param
ing strategy that targets particular high impact critical social thinking skills. The training interventions to be designed as part of this Phase
ile defense strategy effectiveness. This will assist the development of emerging weapon systems tasked to neutralize enemy missile attack
essfully prevents tin whisker penetration would greatly reduce the risk of tin whisker induced failure over the service life of a military system
d performance and back/joint injuries. To address this need, we previously invented and patented a device (the Suspended-load Backpack
lysis process. The need to generate these models for different disciplines, each requiring different modeling abstraction and fidelity levels,
hat include a novel sensor to measure torque-ripple-induced vibration created by electric machinery, a thermal condition monitor that can
expense of running components to failure. That is, the degradation based prognostic technique is an efficient way to develop predictive m
this technology to produce nearly defect-free composites as demonstration samples for marketing structurally strong and impact resistant
e of multiple mobile sensor platforms and improve detection accuracy. To reduce false positives while also maintaining an acceptably high d
as acceleration profiles defined for achieving ignition. Issues related to the integration of the developed novel miniature inertial igniters in
tic field and, thus, has the name electro-magnetometer. During Phase II, we will design and build a new 7-channel GEM-3 array with a 2.4
esearch on IEEE 802.21 shows that MIH (Media Independent Handover) may serve as a component in our integrated architecture, and our r
 des superior performance desirable for directed energy applications using a smaller area than equivalent parabolic antennas and dipole ar
D tags; innovative RFID shelving; graphical, easy-to-configure warehouse management tools; and portable mesh networks.
ntinue creating methodologies and begin implementation in ground soldier simulations. Building off the research gathered in Phase I, Pha
DoD mandate not withstanding, most Class VIII shipments are of less than pallet or case quantity and therefore are not subject to this req
design, modeling, growth, fabrications, characterization and demonstration of carbon nanostructure based detector arrays. Magnolia team
nology to enable commercialization of the materials. The work will include improving the synthesis processes and demonstrating compati
or space use under a NASA-funded Mars Instrument Development Program (MIDP) project ? the Low-force Sample Acquisition System (LSA
environment (and other organically-based energy sources), as well as use conventional and alternative fuels (such as gasoline, heavy fuel, k
y JSEC X-band terminal. In this Phase II project, we will also integrate the SQIF-based LNA with a Ka-band digital receiver being concurrentl
mining battery health. We will also use a dynamic Bayes network to make inferences about future battery health, allowing users to ensure t
llected to reduce the noise level even further. The antenna will view the ground at 45a to collect Stokes imagery, but can collect at nadir fo
profiles, including those due to accidental drops, transportation and handling, as well as to various all-fire acceleration profiles. Issues relat
he small and robust single crystal sapphire transducer is optically excited by a remotely located interrogation system. Using the differential
ployable supply of CO2. Current trapping methods use compressed gas cylinders, which are heavy and considered HAZMATs, or dry-ice sou

be further restricted or halted as wild populations continue to diminish. Opportunities for developing cultured rainbow smelt to suppleme
will design and demonstrate an improved coincidence rejection system based on 4pi's digital pulse processor development, and earlier pu
sed with Silicon-based avalanche single photon detectors (Si-APD). Use of waveguide Sum Frequency Generation (SFG) for 1535nm to 828.
software, the UAS will be able to locate items in the water and either autonomously or thru remote operator input, mark the location of th
roblem by allowing multiple propagation models and databases to coexist for the purposes of analysis, provide a user interface that would
sizes and binary operation per pixel, diffraction from the DMD creates severe problems for many applications. This proposal addresses the
ement ranges: a 40-ohm range (with 0.1uohm sensitivity) and a 400-ohm range. The unit will be able to work from any line voltage worldw
es, as well as for other, related forms of information integration based on ontologies. Being able to selectively manage open world an closed

static mounting on the sea-foor and on land, enabling the observation of both the animals under study but also the environment. ZigBee

od from realizing its potential. The solution is to develop a system with low inherent noise and an ability to improve current sensitivity with

atio in the precursor species. The nanowires will be grown on off-oriented substrates, in an attempt to ensure polytype purity. Various tech
solid-polymer electrolyte configuration. The overall objective of the proposed Phase I program is to develop a sensor to quantify CO2 level
nitors. It provides for environmental control of the sampling and ¿stand by¿ sensor environments via a manifold system that enables autom
e to the complex nature of the ocean environment and the disparate types of sound sources and marine life, the software requires a suite

hanisms will be tested to reduce cannibalism around weaning. Growout feed trials will compare affects of commercial diets on growth rate
ture range of operation, reduce measurement errors at higher temperatures, and increase practical usability of the final product. In Phase
s to extending SC sources to the mid-IR (out to 12µm) are the development of low-loss fiber materials (propagation in conventional glass fi
ta and detect those anomalous behaviors. The system will utilize a Relational Database (RDBMS)/Data Warehouse (DW) Architecture that c
magnetic treatments, the free layer's magnetic anisotropy will be greatly reduced, improving device sensitivity. We will develop improved

net pen will allow remote mortality collection, cleaning, maintenance, inspection and harvesting operations. T his includes hardening of th
nd for rotation to support cleaning, maintenance, sorting, and harvesting. In addition, scuba air is routinely used for many husbandry task
splacement precision was shown to 0.0089 nm (versus the 0.1 nm requirement) covering a working range from 18 cm to 23 cm. The demo
he Phase I part of this project will evaluate two innovative detection methods using single walled carbon nanotubes to provide the sensitivi
areas. A photolithographic mask will lower the incident angle, improving VIPA efficiency. Thin-film coatings will be developed that are ultra
k using current storm track features. Theses three primary tasks will be folded into a prototypical product for delivery at the end of Phase
Phase I, ProSensing developed a prototype compact C-band radiometer (CCR) receiver module that employs inexpensive surface mount co
A and other radar systems designed to extract information critical to forecasters and improving our understanding of TCs, as well as collecti
re prohibitively expensive for most municipalities and agencies. Our goal is thus to develop a web-based system to provide widespread an
m battery. Volume production will keep prices low enough (we aim for $10) that it will be practical to install at least one in each room of a r
pecimen Chamber is a solid design incorporating modern materials, innovative hatch and containment features with a unique adjustable p
easing thermal mass. Also, a method to extend domain engineering to create monolithic broadband position sensors and arrays will be exp
eters limits their effectiveness to perform high-accuracy assays of such materials. STAR Cryoelectronics proposes to develop a high-resoluti

SCUBA, the major one being increased gas efficiency. However, safety related issues limit the use of closed circuit rebreahters, one being t
med through the carbonization of the fibers in the fiber. Tex Tech plans to demonstrate the ability to manufacture lightweight felt barriers th
abricate in-fiber Fabry-Perot filters that meet NIST requirements. Furthermore, our integrated monolithic Fabry-Perot filters will be immun

duces MCR.

ay lead to an interpretation of human health issues. The research undertaken in the Phase I study of nanotubes should help validate the ex
ibly maintaining anaerobic digesters. The principal barrier to implementation of anaerobic digesters is generally considered to be the cost o
to anatoxins and then optimize the composition of a fuorescence resonance energy transfer (FRET)-based sensor employing quantum dot
he future of biomass fuels in America. As the number of users grows, supply of biomass fuels will increase for many years to meet the dem

enjoy modest costs. The one important practical difference between this approach and catalytic oxidation is that catalytic oxidation is not a
etected in water. The ability to mass produce reproducible sensors has recently enabled increased precision and sensitivity. In the Phase I p
experience will help to speed development of the proposed technology to a marketable system.
lication will be completed.

icity. The aim of this work is to show that Ceriodaphnia dubia microarrays can be a practical technology for identifying, characterizing, and
dstock because supplies are abundant domestically and globally. Current methods to break down biomass into simple sugars and convert t
may be adaptable to other types of wet chemical methods to reduce the maintenance and improve the reliability.
er different industries, such as the dairy industry, the beverage industry, the pulp and paper industry, the fruit and vegetable industries, var
are to demonstrate the use of this innovative optical assay for both a toxin and a microorganism present in a fowing stream of water. As p
installations. This would represent a significant advancement for particulate control technology.
ducing a high valued biofuels product with a large and dispersed market. The technology is simple, does not require an external source of h
d amount of G-sand in order 10 accommodate each plants requirement; we foresee test batches of up to 20 tons per plant. The remaining
viable. In this proposal, we present a unique technology/process, the Transport Membrane Condenser (TMC), to recover water with concom
e chloride gas produced. The Kroll-produced titanium sponge is a 50-year-old mature process that is expensive, thus limiting the utilization

reductions.
ve and less expensive feedstocks are needed to supplement the soybean oil that is currently used.

along with Web-based tools, will be developed into the GPSS authentication and registry service. tGT will sell the GPSS authentication and
Phase I, Tok Welding and Fabrication seeks to develop a higher temperature waste combustion unit via the manufacture of a composite ch
e chloride gas produced. The Kroll-produced titanium sponge is a 50-year-old mature process that is expensive, thus limiting the utilization
diction), which may lead to an interpretation of human health issues. The research undertaken in the Phase I study of nanotubes should he
are to demonstrate the use of this innovative optical assay for both a toxin and a microorganism present in a fowing stream of water. As p
along with Web-based tools, will be developed into the GPSS authentication and registry service. tGT will sell the GPSS authentication and
experience will help to speed development of the proposed technology to a marketable system.
to anatoxins and then optimize the composition of a fuorescence resonance energy transfer (FRET)-based sensor employing quantum dot
echanisms of toxicity. The aim of this work is to show that Ceriodaphnia dubia microarrays can be a practical technology for identifying, cha
enjoy modest costs. The one important practical difference between this approach and catalytic oxidation is that catalytic oxidation is not a
installations. This would represent a significant advancement for particulate control technology.

lication will be completed.

rgy feedstock because supplies are abundant domestically and globally. Current methods to break down biomass into simple sugars and co
ve and less expensive feedstocks are needed to supplement the soybean oil that is currently used.

se I, Tok Welding and Fabrication seeks to develop a higher temperature waste combustion unit via the manufacture of a composite chamb
he future of biomass fuels in America. As the number of users grows, supply of biomass fuels will increase for many years to meet the dem

etected in water. The ability to mass produce reproducible sensors has recently enabled increased precision and sensitivity. In the Phase I p

d amount of G-sand in order 10 accommodate each plants requirement; we foresee test batches of up to 20 tons per plant. The remaining

oducing a high valued biofuels product with a large and dispersed market. The technology is simple, does not require an external source of
er different industries, such as the dairy industry, the beverage industry, the pulp and paper industry, the fruit and vegetable industries, va
viable. In this proposal, we present a unique technology/process, the Transport Membrane Condenser (TMC), to recover water with concom
aircraft health management. We propose a new SBIR research program that will adapt and enhance our electronic and artificial intelligence
ch, called “Data Driven Diagnostics and Prognostics”, is based on a physics-free “phenomenological” methodology for characterizing the vib
de in the backshell of a M38999 connector or as a small module built-in or added into electronic systems. We propose new research that w
anchor point. Both these situations would benefit from development of a rugged, durable optical replacement fiber. Ideally it should be a d
protrusions. This can be solved with extruded insulation, but extruded insulations in the past have not met temperature requirements. A si

ansion of the scene as the munition approaches the ground. Innovative Image Processing algorithms are used to determine the Imagery C
SLs) to meet these specifications. OPSL technology exhibits a unique combination of compactness, efficiency, high power, wavelength tuna
feet of helicopters to plan a safe landing for each vehicle.

collisions with ground features or obstacles. According to a recent Aviation Week & Space Technology article, “brownout has been blamed
y comparable to the larger, more expensive intrinsic scalar magnetometers used in airborne MAD detection. Sensitivity will be primarily lim
than fourteen different systems ranging between acoustic, passive IR, and active optical search systems designed to address the problem.
th micro-UAVs among the newest class of UAVs added for deployment at the squadron level the modern war fighter is presented with unpr
ils that can be used to parameterize models. The work proposed here by Areté Associates and David Paige meets those challenges by way
ate the performance limitations of a Strapdown seeker while maintaining all of its advantages. Areté design concepts fit into the following
system for development, parallelization, optimization and execution of code on distributed systems with the ability to adapt and re-optimiz
ng underground facilities by sensing chemical and biological effluents or performing battle damage assessment by sensing changes in the t
feature a modular, extensible architecture that supports a graduated-fidelity model capability from quick-look analyses to high fidelity simu
e, and conduct testing in realistic environments to demonstrate the concept's tactical utility.
a need for data collection systems that can be deployed on small Tactical UAVs. To this end, Areté proposes to design two integrated hardw
e station will be via satellite link. Sensor locations in moored or UUV-borne applications will be determined by outfitting the communicatio
e the need for a towed sensor by utilizing a suite of auxiliary motion and noise sensors to reduce inboard noise on a small platform to level
program will develop a passive remote sensing methodology using imagery from airborne or possibly satellite sensors. In Phase I, we will

ty to successfully communicate and collaborate with local populations and coalition forces. This simulation will integrate Vcom3D’s Virtual
sh idioms. Initial testing of the Mobile LanguageReference indicated a high level of user acceptance and provided evidence that the system
thetic method will be, low cost, environmentally friendly and will yield high quality materials. Commercial applications include coatings for

need to save data at a high temporal resolution. The main component of the proposed system is a library built on top of the open-source Vi
hoosing a single view or a small subset of views that look interesting to him or her, and exporting static images to reports or presentations.
nderstanding of the climate system will improve prediction of the environmental, economic, and human health risks from an enhanced gree
dels that lead to a better understanding of the human contribution to global warming. The Phase I project built one prototype system. The
e designed around thermo-mechanical fatigue test facilities under development elsewhere. One particularly innovative aspect is the prosp
This all-fiber-optical CARS system would enable the use of CARS in more hostile and restrictive environments. Lasers and other delicate equ
in the modeling capability due to the relative novelty of this technique. During Phase I, we will show the feasibility of developing a framew
ted. This proposal lays out a path to practical implementation of a field instrument employing a customized detector/processor unit runnin
aberrations. The effect of compensation is based on building up a point-source beacon on a target and instantaneous detection of the com
r large field studies is the use of focusing schlieren with background grids. Recently, schlieren systems that use the sun as a background sou
d measures the gas velocity directly, avoiding errors due to particle drag associated with seeded techniques. The only requirement is that H
mplete optical characterization, an instrument suite was specified during a phase I study. An experimental and theoretical examination then
combines optical phase conjugation (OPC) with a TIL system for effective hot-spot formation. In Phase I, MetroLaser demonstrated a techn
tion on the order of 30 degrees or better. This is achieved with an array of at least 16 sensor elements with different crystallization rates. Th
ted data reduction software that calculates desired parameters immediately after the test. The scanner can be configured in either direct l
age over other rotating systems such as those with spinning polygonal mirrors. In addition, the number of lines exposed simultaneously ca
technical hurdles having been demonstrated. This project lays out a path to practical implementation of a field deployable instrument, bas
nents have an important bearing on the performance capabilities of the systems that employ them, instrumentation and techniques for pre

red to other approaches such as sinusoidal models or vocoder-based approaches. We will test time domain methods including SOLA, PSOL
mplemented. The objective of this Phase II proposal is threefold; to develop state-of-the-art voice transformation technologies, to develop
ad communications, and utilization of wireless, GPS, and electronic compass technologies to facilitate improving team geospatial situation

cisive Analytics Corporation (DAC) Team proposes an approach termed SOcial Networks In Context (SONIC). SONIC builds on social network
motivating the need for two specific capabilities. First, in order to effectively task sensor assets such that their probability of reacquiring the
the system. Our approach is rooted in rigorous mathematical techniques drawn from probability theory, optimal estimation theory, and op
sor fusion framework for integrating tracking and discrimination. Additionally, we will formalize and automate elements of our innovative M
and our Phase I results demonstrate the ability of our software architecture to run existing physics code with the newly incorporated AMR d
ome these real-world problems through an innovative algorithm that has the potential to vastly improve the quality of measurement assoc
reconfigured on the battlefield. Our approach models mission critical failures by capturing the (possibly many) way that individual compon
another. Dealing with uncertainty requires using a probabilistic representation of reasoning that allows one to express and draw inferences
ble to process and respect the guidance contained in the pre-defined defense plan. Conversely, existing planning tools do little to acknowle
pability (NECC) based upon a Service Oriented Architecture (SOA), where sensors, intelligence sources and battle command systems are im

often delaying critical productivity gains by a factor of years. Significant progress has been made in areas of financial management and ma
the existing Global War on Terrorism. Therefore, reducing the number of aircraft undergoing repair and overhaul at a given time to increa
school students while increasing comprehension; b) that allow less qualified teachers to feel comfortable using the materials; and c) that r

s issues with fish movement, crowding, and mechanical breakage addressed by earlier reviews, (2) develop strategies to retrofit the movin

gative impact on the U.S. seafood industry. Furthermore, mislabeling/substitution of red snapper has negatively impacted the effective ma
gy leverages the power of PCR and the discovery of gene-specific primers to provide a highly reliable yet very simple test readout. The diagn
pansion of intensive recirculating aquaculture. In the waste treatment industry, denitrification has traditionally been achieved by adding m
aculture. Recirculation aquaculture is currently not economically favorable, primarily because of the high costs of building and operating th

h as math, science, and social studies. This project is to develop Youth Map, a software package and curriculum that enables high school st

yield as compared to traditional lines of channel catfish. Production of channel x blue hybrid embryos however, requires much more labor
can not be overstated. Project objectives include research to: 1) verify reliable detection of varroa mites and queenlessness, 2) expand the
l be processed intelligently to give users information about the characteristics and extent of the spoilage for their quality management dec
grain yield during post-harvest storage, help prevent dangerous mycotoxins in the food chain, and avoid financial loss due to the applicatio
articularly in these vulnerable individuals. In related research on Fe sources that are compatible with lipid emulsions, we have identified a n

d with the child’s understanding of the content (e.g., algorithmic errors) as well idiosyncratic differences in the child’s manner of respondin
ation. Systems showed excellent stability. Engineering and economic analysis projected system costs less than $1,000 with payback time of

tion more naturally in a work or school environment. Phase IIproject goals include: (1) enhance the Hearing Companion device and applica

posed approach minimizes the reliance of soil WRC estimates on other soil data sources and utilizes more information obtained in a quick a
uring andusing
gs, and transportation economy,
a fully-automated it will
stove to be critical
burn to diversify
the logs biofuel
for heating. fuelphase
While typesI and sources.
of the projectTowill
address this national
be focused priority,
on feasibility Farasis
study andEnerg
labo
ers. Because biomass is a renewable energy resource abundant on farms, use of this new technology will reduce the nations consumption o

consuming, expensive and requiring specialized equipment. Rapid testing with a low cost immunoassay device would enable early detectio

atural infection. The PD and collaborators have recently demonstrated the effectiveness of using RP vaccines in pigs and the importance of

one in Hawaii.

ware and planning services, and (4) further refine the Global Wellness business model.

due to the rapid loss of critical semi-volatiles to surface adsorption. Phase I efforts resulted in the identification of an improved material fo

del and physical properties of the system. Furthermore, students may unknowingly construct a molecule that simply cannot exist in nature
 or innovative boost to OSC business.
N would therefore support and encourage present trends for placing new utilities below ground, helping avoid future problems with such in

cally above the surface at some height within the saltation layer.This vertical obstruction disturbs the aerodynamic medium by creatingturb
tilation for temperature control wastes CO2 and supplemental lighting becomes the less expensive alternative. Real-time, adaptive, contro

ate and container materials in order to provide high resolution x-ray images of plant root structure. This x-ray imaging can be repeated on t
RS and PSC compared Poplar tree seedling growth and root development in both soils and PSCs artificial substrate and container materials

n tools that allow the students to perform all phases of the experiment (experimental setup and operation; data collection, analysis, and re

recombination substrate, resulting in replacement of the wild-type locus. Seeds will be collected and the desired mutation should appear i

e II of this SBIR program, Safe proposes to continue the detailed design effort and to build and test a prototype of the design to demonstrat

used on producing nematodes in mealworms. In Phase I, we determined the basic requirements for mechanized production and establishe

rget safety. Further, we intend to verify the economic validity of commercialization, both from the perspective of the product producer and

udents driving race cars and then stopping them to learn about inertia students dropping items of various masses on the earth and the mo

ne is the material of choice. The objective of the proposed research is To develop cost-effective pads and sheets that include manure as an
rough system rather than a sequencing batch system. The leftover organics from hydrogen production, mainly volatile fatty acids can be con
uccessful the total energy produced by the digester would be higher and the cost of hydrogen production would be lower than that of othe
em, the central
munogenicity communications
and protection. BG computer, will Gram
are non-living incorporate a microcontroller
negative and wireless
bacterial cell envelopes communications
created after lysis withtothe
relay information
cloned requiredgen
bacteriophage to
ccine against this pathogen and development of such a vaccine is of great importance to the cold water aquaculture industry. F. psychrophi

tigued animals. In this trial, increasing dEB by 400 meq/kg feed did not affect lactic acid production during aggressive handling, but did imp

p a replacement to existing neutron tube sources for applications that benefit from a fast neutron pulse.
such distributed code breaking software called Distributed Network Attack, or DNA. The Distributed Code Breaking Silo is a project in whic
mbination of these two technologies will provide the acquisition characteristics required by the DHS and will operate night or day and in adv
ssion geometry and an ideal acceleration voltage, the expected neutron energy will be less than 8.5 MeV to prevent the emission of interfe
n and tracking system based on the Navy&rsquo;s lowcost passive sonobuoy sensor, manufactured by Sparton Electronics, and sonobuoy p
named rescue spreaders. The problem with current rescue spreader systems range in weight from 60 to 125 lbs and are comprised of sepa
and Vidiation LLC developed and are commercializing a software solution designed to reduce the likelihood of malicious use of radiologica
e, and has a long battery life is desired. AME proposes in phase I to conduct a trade-off analysis based on DHS requirements. The output w
that its use will increase detection sensitivities of such devices by at least an order of magnitude. Furthermore, its simplicity should help re
m against
with remotesuch attacks.
sensing willThe
beproposed
completedsolution
in Phasewill
II. be upgradeable in the field by replacement and/or reconfiguration of its firmware, softwa
ve detection technology, and while doing so we learned a tremendous amount about the key components necessary for a responsive and e

r networks that signal the presence of radioactivity. The complexity of these systems grows exponentially as a function of the number of se
ellbeing of their team. Experience from serious emergency events prompted our team to collaborate with multiple emergency response ju
aterials (such as highly enriched uranium and weapons grade plutonium) and nuclear weapons. An important challenge in homeland secur
bstantially improved to demonstrate accurate radiation identification capabilities. Using neutron signatures represents a promising solution
ns grade plutonium. Neutrons and gamma rays are two signatures of these materials. Gamma ray detection techniques are useful because
urrent for a neutron source, enabling fast switching, high repetition rate and high yields. Carbon nanotubes (CNT) possess two unique char
city of a 10 mCurie 63Ni beta source, with continuous operation for over 300 hours. In Phase II, ANI and Sionex will develop a complete Diff
m platforms and automated guards has proven to be unworkable for multimedia applications and cost prohibitive for most civilian environm
all gas molecules. This concept exploits the unique electronic properties of SWNTs together with the tremendous potential of chemistry to
dquo;. Our goal is to defuse a potentially dangerous carchase by disabling power to the vehicle while leaving braking and steering unaffect
ommended FPGAs can be used in parallel on a single desktop computer. During Phase I, Crucial Security will design and develop a proof of
hile sensor put out information, making sense in quick fashion of the data is paramount. A system such as Optima HLS that can fuse data fr
¿s sensitive information, and 2) protect an organization¿s Information Technology (IT) infrastructure from outside penetration. Instances of
gnition and Control Flow Graphs,CFG, to determine invariant attributes of the malware communications. The system then implements prev
t more than 10 times the energy of a small passenger car and a stopping device must work over this broad range of kinetic energies. Our re

that we will successfully complete and commercialize the efforts of this SBIR.
tor of 3 less radiation. Another objective is to significantly reduce the overall size and weight of the linear accelerator (linac) system. We wi
e highly efficient neutron detectors, now under development at the Lawrence Livermore National Laboratory (LLNL). The substrates for thes
TS sensors, wireless communication devices and data storage specifications. The proposed integrated suite of hardware and software will p
ntaminants must also be addressed. A non-contact handheld collection system is proposed that could readily be scaled to a variety of large
e and the signal-to-noise ratio can be greatly enhanced. This results in significant reduction in false alarm rates. Since the number of the de

. The fexibility and adaptability of wireless lowers the physical and cost limitations posed by wired systems. However, as ICSs are adopting
els require many sensors, which can be prohibitively expensive. After an explosion, the sensor environment is extremely harsh, and the tun

m against such attacks. The proposed solution will be upgradeable in the field by replacement and/or reconfiguration of its firmware, softwa
antly better protected infrastructure. Key Words
 ers caused sharp decreases in injuries to both police officers and suspects. It is expected that a longer range device would provide the sam
ed by TSA operators provide only imagery of the density of items within screened luggage. Detection based on density images is insufficien
ase the probability of detection for human targets in open water. The Wide-Area Infrared Imager (WAIRI) covers broad sweep widths from
mpatibility with 12 gauge shotguns. Piezoelectrics enable efficient high voltage generation in a small package, and can be designed to delive
astructures but also contribute to the botnet community knowledge base enhancing DHS cyber security mission.

re system that is applicable to multiple detection technologies and has the capability to detect low-level signals from generalized inputs. Ou
highly sensitive towards reactive small molecule gases and that can withstand repeated exposures to multiple reactive gases. In addition, w
atory operated by National Security Technologies (Andrews AFB) for calibration and performance of the detector system with 252Cf and gam
mproved chemiresistor sensor array prototype by design and creation of molecularly-mediated thin film assemblies of nanoparticles as sens

es. With the availability of new materials, computing power, and components that were unheard of 50 years ago, an advanced betatron de
ers, glasses, and ceramics. The device implements improved time domain dielectric spectrometry. In addition to a simple capacitive probe,
oughput of at least six individuals/packages per minute, collecting enough sample material to be detected by a commercial trace-explosive

D3S is an ultralarge aperture narrowband light generator (NLG), which emits light at two periodically modulated wavelengths: test and refer
90% probability, even during harsh weather conditions and at night. HiProWSer will not be seriously affected by aircraft speed or altitude.
THz gauge system and all aspects of total life-cycle costs are considered, customers will realize a significant return on investment by replacin

p (QSPR) study and the first generation materials will be modified using the calculated interaction of the analytes with the material surface.
orms quantitative, immunodiagnostic and DNA tests. Advantages of the Talon Biosensor include nonoptical, direct onchip detection; easy t
developing a toolset in which different reliability can be quantitatively combined and compared on real data from real algorithms.
elocated. This data will be reported, wirelessly, to a central command station. The command station will monitor the local hardware and pr
gsystem
boron will
as abe sensor-neutral facilitating
neutron-conversion material.the integration detector
A gamma-ray of currentwill
and beemerging sensor technology.
readily incorporated into theThe
sameprototype willpiece
monolithic incorporate
in ordermultip
to eli
reas can be manufactured at costs below those of conventional neutron detectors for portal screening applications.
emonstrate superior performance in multipath environments with better use of the spectral bandwidth. The various innovations are requir
ayers are now standard for many control systems, it is becoming easier to eavesdrop and spoof these networks. As these wireless control s
ported as lost or stolen each year. These units pose an obvious security risk. They are also an environmental risk due to the improper dispo
t of a global biometrics screening capability will require exploratory development in the areas of biometrics data processing and communic
ntrusions in cargo while it is in transit, where exposure to publicly accessible areas is higher than within the confines of a port facility. A suc
e proposed detector. This detector takes advantage of opportunities for long-term signal detection and integration to detect even low-level
ption strategy can be designed for specific missions. Security implementation prevents penetrating vest through Body-LAN, P2P network an
easurements and an off-body
these environments. ad-hoc
This research network
directly of mobile
benefits fromnodes that transports
prior effort conductedthese measurements
by ZonTrak to the
and leading commander
nuclear researchs institutions.
station. Our soluti

que uses ERCo s patent pending eye-safe laser technology and UDTs advanced signal processing. We have experimentally verified the techn
nspection of the cargo. If the film is cut or punctured the liquid will be released. It will then react with the atmosphere to form a dye that s
which lead to valve failure. The fow disturbances created by mechanical valves include high velocity jets, turbulence and areas of stagnation

rapidly. However, good MRI will allow serial progression studies of diseases and treatment of live animals, eliminating the need to use a lar
t's Braden Risk profile when proper precautionary standards of practice are followed. While reduction to zero may be unrealistic, especially

dely used method for preparing samples for microarray analysis, which uses cDNA synthesis from mRNA followed by T7 RNA polymerase-b
will enable the user to adjust the backrest position while seated in their wheelchair. The benefits of the design are lightweight, high strength
 compounds. The wide adoption of these techniques has led to im- proved methods for representation of chemical structures, similarity-ba
tigators must make special security arrangements to obtain these ?les, which they can not redistribute once they complete their analyses. T
onnect density. The proposed research and development herein will simplify the interconnects and optimize the beam forming capabilities
rized by the proliferation of abnormal blood vessels under the retina, leading to fuid or blood leakage and to eventual blindness. The dry f
f environmental exposure-thereby reducing national healthcare costs and producing safer working/living environments. This exposure to e
earing channels. In the Phase 1, we developed a research cochlear infrared nerve stimulator and identified the need for a small pulse width
eys and registries sponsored by NIH and other federal agencies. Through expanding the capacities of MedRIC, Acumen will establish an infr
eys and registries sponsored by NIH and other federal agencies. Through expanding the capacities of MedRIC, Acumen will establish an infr
eported glyconanoparticles were prepared by conjugating thiol modified carbohydrates onto nanoparticle surfaces. However, the preparati
es and monosaccharides) allow high-throughput, parallel analyses. Parallel analyses greatly facilitate not only surveys of proteins for carbo

who desire their child have a normal appearance. Parents most often select more cosmetic devices designed to mimic the anatomical hand
d compound characterization are conducted, and University of Virginia laboratories of Drs. Wendy Lynch and Jay Hirsh, where compounds a
onsiderable attention as a procedure with the potential to cure patients with diabetes. Allergenic transplantation as a potential cure for typ
clodextrin (beta-CD) having a sevenfold symmetry could block the heptameric pore formed by Bacillus anthracis protective antigen (PA) an
eitan, Wechsler memory battery), neurophysiological measures (e.g. electroencephalogram, Multiple Sleep Latency Test) and behavioral tes
will not be treated with Continuous Positive Airway Pressure (CPAP). Advanced Brain Monitoring (ABM) developed and validated the Apnea
ain, nausea, vomiting, muscle cramps, dizziness and fainting, slows or terminates the dialysis run, reduces the quality of dialysis, and costs
aximizing the number of conditions screened. Also, conventional laboratory analysis of blood samples in a birthing center is impractical.
e wireless sleep sensors and created a polysomnograph recording and analysis software package for use with the developed sensors. This a
manage their conditions. Each day, patients decide what they are going to eat, whether they will exercise, and to what extent they will take
a minimally trained person to make the attachment to a patient and collect a 30 minute segment of data. In phase I, AME will identify the m
cally ill children represent a broad population of patients that are more frequently affected by acute, life-threatening illness than the gener
er Doppler measurements). These tests seek establish the feasibility of using microbolometer based IR imaging to analyze the effectiveness
ody movement protocols such as yoga, meditation postures, and tai chi. Data will be collected in real time from wearable sensors using a lo
opulations including ataxia, dystonia and Parkinson's disease. The current state-of-the-art for wireless EMG applications is a collection of EM
nic map of magnetic anomalies (or, "signature") to determine current position within a building. The phase I developed prototype system t
comparatively evaluated in human tests against a tethered system. The developed UWB wireless system will be suitable for applications su
t phenotype but not to the host's normal tissues, improving outcomes while minimizing systemic side effects. Anti-HER2, Herceptin, leads t
ntibody probes from a single tissue section to numerous bioaffinity membranes permits multiple target antigens (up to 50 if needed) to be
sis. The immune system responds to tumor-associated protein by secreting autoantibodies long before metastasis occurs. Autoantibody pr

or early stage clinical trials. However the frequency with which it generates replication competent adenovirus, which disqualifies from 10 t

s with encouraging anecdotal results. However, its clinical efficacy has not yet been assessed for any tumor type. Thus, clinical Phase Il and
oxide and carbon monoxide are markers of airway infammation and ethane is a marker of lipid peroxidation. In addition, carbonyl sulfide
nhaler (MDI) is the most common form of treatment, with nearly 50 years of patient acceptance, physician confidence, and FDA approval.
ade, new, highly-effective antimalarial therapies have been developed based on the Chinese medicine component Qinghaosu (artemisinin)
tified for pain therapeutics. Genome-scale technologies such as gene expression microarray data have contributed an exponential amount o
vascular, metabolic, endocrine, and mental functions. The nation's increasing "sleep debt" has recently received great attention in the med
chers need new testing methods and instruments. Currently, three of the most commonly used behavioral cognitive tasks, the Morris wate
hatics or vascular drainage. Cells that remain in the tissues face additional challenges related to infammation and survival. Those cells that
m bacteria that establish themselves on implants are essentially impossible to eradicate by any means except explantation. New technolog
old standard because of its osteogenic cells, osteoinductive factors, and osteoconductive properties. However, because of procurement mo
f complications and often provides an inadequate volume of graft (Gupta 2001). To address these limitations, much work has been done to
2006 Omnibus Solicitation. The proposed device will be an unobtrusive, low-power, wireless device that attaches at the wrist (similar to a w
mpact on periodontal regeneration. Perlecan, originally named heparan sulfate proteoglycan-2, is now known to be an important componen
mpact on periodontal regeneration. The objectives of this project are both scientific and developmental in nature. Scientific advancements i
ent in technology during the 1990s, K-12 science education fails to excite students. Technology has become prevalent in science education
requires the development of a personal environmental monitoring device that measures the exposure of the individual to environmental fa
ech synthesis for communication. In addition to improved naturalness and intelligibility, the ModelTalker and InvTool software uniquely offe

n reducing unwanted side-effects, but the antagonists themselves cause serious side effects (e.g., excessive abdominal cramping). Based on
uggests wider use of open source software to address integration challenges. I This project will build on Akaka's OpenClinica platform, the l
panders expand immediately which may damage sutures related to the implantation wound. Neither of these technologies has the capabi
eptococcus, Mycobacterium tuberculosis, Mycoplasma pneumonia, Haemophilus infuenza, and Staphylococcus pneumoniae (12 pathogen
lness. The recent outbreak of avian infuenza H5N1 in East Asia has further fueled concern over another pandemic and emphasizes the nee
arrays (MEA) or automated confocal imaging can provide information on neuronal connectivity and integration, firing patterns, and neuron
carried out in each well and the results of the assay are most often evaluated using an optical detection technique. Typical optical detectio
with TBI occurs, rapid response is critical to limit the impact of the secondary damage due to increased cranial pressure and abnormal chan
ew, efficient, high- throughput detectors are needed. Such detectors will enhance the quality of the molecular model, which is the end pro
, neutrons can easily penetrate many heavy elements, but are readily absorbed or scattered by various light isotopes, like hydrogen, deuter
r imaging. Special emphasis is on developing biomarkers, which will predict the development of invasive and non-invasive cancer after trea
m a number of consumer products in which lead was accessible to children. These products of serious concern include imported crayons, im
al use. To overcome these drawbacks, we have in our previous work developed a translucent LSO optical ceramic, which displays scintillatio
of the tracer is imaged dynamically, allowing the rates of biological processes to be calculated using appropriate mathematical models. PET
ent sensitivity; however, use of this powerful modality for many important functional studies is limited due to their slower speed of operati
g studied and are a useful tool for understanding the functioning of the organs as well as diagnosing symptoms of diseases. Nuclear medic
al resolution and the lack of anatomical information in PET. Magnetic Resonance Imaging (MRI) can provide high spatial resolution and exce
ns and water, because they interact directly with light nuclei, not their electron clouds as in case of x-ray diffraction. However, the use of th
e explicitly. A fact may not be true but we want to develop software that finds those facts. What does a fact look like? Consider the followi

s context that we propose to develop a new technology, which is free from the aforementioned limitations of the conventional particle agg
tic studies. Most clinical laboratories and hospital transfusion services use manual test tube hemagglutination methods to perform anti-D
tion of alcohol results in many changes in the brain that contribute to the development of addiction including progressive neurodegenerati
mechanism that is fundamentally different from that of clinical antibiotics and is therefore unlikely to promote resistance. Coatings will be p
ing a malignant lesion may have led to a low positive biopsy rate for cancer, between 10-31%. Unfortunately, breast biopsy is neither a ben
ment strategy in targeted radiotherapy. Alpha-radiation is so densely ionizing that it forms destructive radicals directly, independent of oxyg
osed this year and 97,070 will die from these diseases (American Cancer Society 2005 Cancer Facts and Figures). This promising cancer res
ring Phase I of this project, AlphaSniffer will develop glycan microarrays for the detection of two plant lectins, Concanavalin A and jacalin as
ays, and effective treatments for autoimmune disease. During Phase I, we developed a novel, low-cost, high throughput approach for prote
nes is extremely important in order to effectively adjust the drug treatment for these patients and also for drug-na ve patients. DNA sequen
h include the fecal occult blood test (FOBT), a non-invasive fecal DNA test (PreGen-Plus) and endoscopic colorectal examination (colonosco
hest prevalence rates for a genetic disorder (~1 out of 4,000 births). Progress has recently been made in identifying possible drugs for this
opathological analysis of biopsy tissue. However, this approach fails to detect ~20% of patients with cancer. Since nearly 1,000,000 prostate
bead-tagged probes for detection of specific sequences. We have successfully developed highly multiplexed DNA- and RNA-based assays u

e-clinical trial, we showed AMES to be effective at restoring functional movement in both upper and lower extremities in a majority of profo
a formidable general barrier to structural determination: the need for membrane mimetic media that are suitable both to confer aqueous
d hygiene. As a result, nosocomial infections will decrease, saving lives and money. The Phase I research will demonstrate RHHP in a hospit
levels of NO for a sustained period at gastric pH (2.0), making it an ideal agent to deliver NO to the stomach. The NORTECH will be tested i
tudies that identify and develop new therapeutic strategies that attenuate hepatocyte death, promote hepatic regeneration and improve o
ctor (SF/HGF), is a renotrophic factor with anti-apoptotic and anti-fibrotic properties. However clinical feasibility of SF/HGF administration a
cation in lung transplant recipients. Current preservation fuids (e.g., low-potassium dextran glucose, LPDG) reliably preserve harvested lun
a. Receptor tyrosine kinases have become major targets for cancer therapy due to their critical roles in tumor growth, invasion, metastasis
$1.5 billion. Morbidity represents the major cost burden, with costs of $819 million (56%) of total costs. The current value of lifetime earnin
sually occurs between 30 and 50 years of age. RA often goes into remission in pregnant women, although symptoms tend to increase in int
catter factor (SF), has documented scattering, proliferating, and protective effects on neurons in the brain, spinal cord, and in peripheral ne
for children of ages 17 and under, with a prevalence of 2.6% and an incidence of 43/100,000 children per year. The incidence of brain injur
erobic bacteria could not grow in viable tumor tissue. Therefore, more effective targeting is necessary, especially in the viable tumor tissue.
ure. However, despite all the benefits of these replicon systems, the lack of an infectious HCV system in cell culture is still an impediment t
ill be demonstrated by synthesizing three peptides of varying sizes; a 12-mer anti-fungal peptide, a 40-mer psalmotoxin, and an 86-mer, pro
is completely non-invasive and can be performed by an unskilled operator with a minimum of patient burden. Our Phase I aim was to dem
of a primary alcohol, PLD2 can catalyze a transphosphatidylation reaction to generate phosphatidylalcohols. In particular, PLD2 acts to conv
synthesis of vitamin D. The biologically active form of vitamin D has been shown to have strong antiproliferative effects in cancer cells, but i
dren snore, and most sleep laboratories do not have experience with children. All parties agree that an in-home assessment system could
phingolipids are being increasingly recognized as key mediators of stress responses, cell differentiation and proliferation, and are known to
apy to totally prevent diabetes- associated complications, the limited availability of human islets for transplantation, and the rejection of is
ancer immunotherapy. Therapeutic vaccines represent an attractive treatment modality for the management of cancer, primarily due to the
s/TSAs into professional antigen presenting cells (APCs), and/or the presence of significant immune evasion mechanisms may contribute to
e and delivery of siRNA constructs into the thoracic cavity than current alternatives. Prior research shows that modified APMS effectively tr
he trial-and-error type, where frequently only one in 1,000 experiments provides a crystal hit. Often these initial hits are difficult to detect b
engine will be available to the user to visually demonstrate the known time course and effect information of the drugs commonly used to i
ay in the ICU by 425 patient days and consumed 15% of the ICU's resources. Critical care clinicians discover critical events earlier and diagn
el include the probability of loss of consciousness and loss of response to various noxious stimuli. The model was evaluated in the operatin
an be used by scientists and heart valve designers, for example, to investigate new hypotheses on the unsteady hemodynamic aspect of ca
higher enzymatic activity and platelet inhibition than the wild-type apyrases. Importantly, APT102 conferred cerebroprotection against exp
ngle biggest cause of early morbidity and mortality for lung recipients. Apyrase strongly inhibits platelet activation and infammation with m
d traps, Aedes ovitraps). These technologies require time consuming identification of adults or rearing of eggs for larval identification to sp
res on sheepshead minnows using several anthropogenic compounds (pyrene, copper, cadmium, and bisphenol A), then use the microarra
die of the disease each year mostly due to delayed diagnosis. Worldwide more than 1.2 million new cases of lung and bronchial cancer are
notion that the patient understands the procedure/therapy as well as its benefits and risks. Unfortunately, this is frequently not the ca

e better understanding of both common and rare diseases. Current methods for managing precious liquid samples are fraught with problem
y of data search, access, and analysis can be greatly facilitated by the development of domain-specific knowledge bases. A knowledge base
surface polysaccharide alginate. The long term goal of this project (which is outside the scope of this application) is to investigate the use o
he young patients are destined to progressive neurodegeneration and death. The limiting factor in the future treatment of these diseases is
gnificant advantages in cost throughput, scalability, and fexibility over existing bead-based liquid array platforms. We will develop a liquid
skill, and enhance colorectal cancer screening procedures by making them safer and more comfortable. Improved training and developmen
s, much progress has been made in the field of angiogenesis research, fueled by the hypothesis that inhibition of angiogenesis would be a

tumor to assess the tumor response via histopathology. Mouse models are increasingly used in the study of possible cancer treatments an
detected. The system will be based on continuous spectral measurements in the combination near infrared region. Through the use of a cu
m patients suspected of being exposed to potentially harmful levels of organophosphate-based pesticides. This represents a novel approac
red intravenously (IV) or intracerebrally (IC) one week post-HI injury. Syngeneic and allogeneic MAPC demonstrated statistically significant e
mal Care and Use Committee (IACUC) must assure that appropriate anesthetics and/or analgesics are used to minimize or eliminate pain and

e causative agent responsible for Buruli ulcer, a devastating skin disease present in several countries. The proposed approach is to create a
oise exclusion; 3) high inter-subject variability in sound pressures delivered to human ears; and 4) poor comfort. The occlusion effect necess
are quite common. Currently as many as 70% of hospital-acquired infections in the US are resistant to at least one antibiotic, and about 40%
ensions of the corticosteroid rimexolone; 2, test the in vitro release characteristics of these formulations into buffer; and 3, test the in vivo p
city due to higher than necessary peak levels. In addition, non-adherence with the daily oral dosing regimen is a major cause of graft failur
in some patients but often requires frequent injections because of its very short half life. We have developed a proprietary subcutaneous
to the number who die from breast cancer, and forty times more than those who die from cystic fibrosis. The effect of pulmonary fibrosis
e photon emission computed tomography (SPECT) imaging with 123 I-IMPY provides a biomarker for detection of amyloid plaques useful fo
e most exciting emerging technologies for measuring BCM is positron emission tomography (PET) imaging using C-DTBZ, a tracer which bin
are under treated primarily because repair options are limited and ineffective. The clinical gold standard for repairing PNS injuries that cann
as muscles or sensory organs. Peripheral neuropathy refers to the disease process of sensory loss, pain, and weakness that occurs in the le
enhance factors associated with antitumor activity will improve the safety and potency of this biologic. To address this hypothesis we prop
he individual, their family, and by society. However, mild and moderate TBI is challenging to diagnose. Conventional methods such as imag
y concordance, and "snapshot" functional assessments by physical therapists and/or occupational therapists. The central objective of the P
mately 85% survive. These infants have an increased risk of long-term developmental disabilities, with approximately 5-15% exhibiting maj
with significant reduction in both the required number of questions and assessment time. Existing multidimensional chronic pain assessme

s in context with existing needs for rapid and reliable biological indicators (BIs) for sterility testing, BCR proposes a Phase I study to evaluat

omparison can dramatically accelerate BLAST and other algorithms used to annotate sequences. However, the utility of these hardware acc
ms to a college student population. The DCU intervention consists of integrated assessment, feedback and decision-making modules. The p
ors. SMART Recovery is a non-profit educational organization with a self-help/mutual aid component. SMART stands for Self-Management A
t and non-immigrant versions of the Hispanic Stress Inventory-Adolescent (HSI- A.). A cross-sectional research design with a nested test-ret
business, Behavioral Tech Research, Inc., a company dedicated to disseminating effective psychosocial treatments. BA is an evidence-base
loping innovative training programs for psychosocial treatments, and the Center for Anxiety and Related Disorders at Boston University, wh
lator of G protein signaling" (RGS), that attenuate GPCR signals by increasing the GTPase activity of associated Ga proteins, has opened up
rtance, screening tools for high throughput analysis of neutrophil recruitment are limited and there are none that allow quantitative measu
Microfuidic Reconstituted Tissue Device (fF-RTD) that will enable more physiologically relevant cellular assays in a high throughput, autom
uired for beta cell /islet differentiation and expansion. Based on this murine assay, we propose in this study to develop a HuES based assay
enefits of Bexion's proprietary first-in-class biotherapeutic agent in treating common primary and metastasized cancers, including prostate

ontraction (LC). Recent randomized controlled trials suggest that eliminating the SC-phase and applying a larger-than-normal load to the ag
vascular disease, hypertension, obesity) and are useful to researchers trying to identify both causes and treatments of these diseases. The

reduction leading to partial reduction of the carbonyl group occurs in most cases. The only promising methods reported this far use microw
ct, we have revealed for the first time that malignant melanomas in mice generate an electric field that can be easily detected by the BFI. T
etecting cancers, has yet to produce an efficient method for either biopsies or localized therapies. By developing a fully MRI-compatible rob
rdized and cannot be integrated between or within laboratories, and relatively few raw data are available from federally-funded research, d
asing the risk of metastases. Biologics targeting the tyrosine kinase (TKI) domain of EGFR are being developed, and are currently at various
teins. As such, bringing this novel technology from the university laboratory to the market place is a challenging task. The overall goal of th
aims of the project are: 1. Design and construct prototypes of single sample tangential fow, hollow fiber, ultrafiltration devices. 2. Chara
s pathogens. It enables a scientist to scan nearly 2,000 phenotypes of a microbial cell line in a single experiment. This technology can now b
r long-term monitoring of critical care patients. It is especially important for first responders to properly diagnose and treat a pneumothora
the cytokine type, selectins and other molecules that rapidly mobilize the infammatory response with subsequent global organ damage. T
sed in the operating room--not in an emergency at the site of accident or in the battlefield. The goal of the proposed project is to develop a
ies, and time-varying maps of environmental contaminants are poorly characterized in the GIS environment. While current state-of-the-art
lative risk, identification of clusters and hotspots of significantly high or low incidence or mortality rates, detection of significant discrepanc
 ters over the life course and risk factors/covariates are not included in the analysis. These limitations are overcome by this project. Local, gl
not allow for real-time, continuous monitoring of IOP (24/7, diurnal and nocturnal readings). The long-term objective of this project is to en
alization and analysis of chromosomal and megabase fragments of DNA extracted directly from a sample (possibly a single cell) with sub-ki
h. Unfortunately the production of polyclonal antibodies to peptide antigens currently requires the chemical synthesis and purification of p
al diagnosis of multiple diseases. In the absence of erythema migrans, the classic skin lesion of early Lyme disease, the diagnosis is establis
measures to control B. burgdorferi; there is no human vaccine available, and, existing vector control measures are generally not acceptable
care costs. Early detection and treatment of kidney disease has been shown to improve outcomes, but kidney disease is often under diagn
adily taken up by cells. IVST is beginning to be used by scientists to determine the quantity and location of cells, such as stem cells, transpla
nnually at a cost to the healthcare system of over 6 billion dollars. Magnetic resonance angiography (MRA) offers a noninvasive and potenti
inhibitors to treat diseases including rheumatoid arthritis and infammatory bowel disease. We have reported the discovery of TL1A, a TNF
asing evidence indicates that aberrant apoptosis (programmed cell death) plays a key role in sepsis-related death but currently no drugs to
tissues with micron-scale resolution noninvasively. OCT systems based on the original time-domain interferometry technology have been s
ing to narrow the health care quality gap between the developed and developing world. In the awarded Phase I, BioScale, Inc. and Dr. Will
polyketide natural products. The chromosome engineering approach that we will pursue will require the development of two technical com
ow detection of gene expression changes over a range of 5-7 orders of magnitude. Few suitable reporter genes limit simultaneous high thro
changing ambient electrical fields. Compared to conventional 12-bit systems, DT digitizes small fast action potentials and large slow brain fi
y available speech. Modern "concatenative" speech synthesis technology can mimic a given speaker's voice, by excising speech fragments
adherent microbial populations is decreased in IBD. We also identified putative peaks in LH-PCR fingerprints that may indicate patterns ass

had limited success largely due to limitations in using culturally appropriate messages and media. Public health needs demand the develop
very of many of the above agents presents new challenges for aerosol delivery systems. In Phase I, we demonstrated the proof of principal
ations including food and water safety, bioreactor analysis, sterility assurance in the pharmaceutical industry, environmental microbiology,
ed in diabetics if blood glucose levels are maintained as near normal levels (60-110 mg/dL) as possible, so called "tight" glucose control. The
hnology, we created a novel class green fuorescent caspse-3 substrate that is capable of detecting caspase activity within individual live ce
y the modest success rates of the assays and by the high cost of the consumable patch substrate. Currently, typical success rates for a stand
tacles or a hat, and a compact computing device and set of controls that fit into a pocket. The Smart Telescope advances today's state of th
ses through a small, deep incision, which offers very little visibility of the affected anatomy. Replacement of the glenoid surface is the most
d ovarian cancer. Interferon-gamma has a short half-life after subcutaneous administration that necessitates frequent administration and r
ted process under the infuence of the host microenvironment and a number of secreted mediators. Many proangiogeneic mediators are e
hese MEMS-DMs, which will be produced using silicon wafer batch-manufacturing. Based on prior research, it is estimated compensation o
In patients with these conditions, the quantitative blood D-dimer assay consistently shows a diagnostic specificity below 25% for PE, thus l
l infection can cost as much as $47,000 per patient to treat. Although invasive medical devices such as stents and catheters are pre-sterilize
ntal plaque or generalized killing of oral bacteria with anti-bacterial compounds. These "remove all, kill-all" approaches have shown limited

e accurate, sensitive, and affordable, high-throughput proteomics methods will be available. Our goals are: 1. recognition of protein interac
ucts and metabolites. We propose to develop BRES to define patterns of response to benefit the Gene Environment Initiative, focusing on x
laboration with Los Alamos National Laboratory, developed XRpro. This technology allows the identification and measurement of CAM adh
e lack of therapeutics for ALS treatment is in part due to poorly described disease etiology. Four hypotheses have been advanced to explain
europrotective in response to cellular stresses. We therefore hypothesize that increasing the level of DJ-1 protein in the brain may represe

ently, no effective means exist to provide accurate, inexpensive, non-invasive point-of-care evaluation of persons at risk for dehydration. In

l is to improve patient morbidity and mortality in acute myocardial infarction and chronic heart failure. The Applicants' research is aim
 effective chemotherapeutic agent used extensively in the treatment of lymphoma. Unfortunately, its clinical efficacy can be inadequate, an
rebral oximeter would have a wide range of applications, both in basic research and clinical settings. However, current cerebral oximeters h
ed trials demonstrating its efficacy in reducing problematic drinking and alcohol-related harm among college students. While a BASICS man
y in PSAPP (APPswe, PSEN1dE9) mice when multiply injected with low dose of Saneron's human umbilical cord blood cells mononuclear fra
progenitor cells from adult pancreas that can be used in the development of cell therapies for multiple patients from a single pancreas don
isolated events of cell processing, as has been the focus in the past, but in fact a more comprehensive and strategy involving process integ
hese solutions, sold by CPSI's marketing partner BioLife Solutions Inc., are used in FDA-approved cell therapy IND'S. These same data on str
n stress pathways are also being used to potentiate cell death in cancer cells during ablative freezing processes - a regime that couples trad
erm goal of this project is to develop and commercialize a proteomic method for isolating, identifying, and quantifying lysine acetylation sit

siologically regulated, and the biological consequences of these phosphorylation events. PhosphoSite(r) was designed primarily to curate a
mal models. The value of this proposition is to improve prediction of drug toxicity during the expensive and time consuming human clinical
ew drugs en masse. Phage display is a unique tool for the discovery of peptide ligands, design of peptidomimetics, and biological validation
(RNAi) has proven to be an extremely potent and versatile tool to specifically reduce expression of targeted genes, allowing for loss-of- fun
be gene function en masse. RNA interference (RNAi) has proven to be an extremely potent and versatile experimental tool to specifically re
are few effective post-exposure therapies. Direct cellular disruption, upregulation of chemokine/cytokine production, microbial invasion in
fu virus derived from cultured cells. We propose to couple the polymer to a resin appropriate for biomanufacturing, which will be used to
mpanies. For it to be effective, however, HAART has to be monitored to avoid the risk of rapid development and transmission of resistant st
$45,000 per day, identifying candidate drugs with the potential for cardiac toxicity early in the development process produces significant s
his problem, Centice proposes to develop a fast, accurate and affordable system for spectroscopically identifying and verifying prescription
and quantitative rapid test platform, we focus on development of a novel lateral-fow based cardiac immunoassay system. Centice Corporati
nificant challenges to fabrication of these devices. A fine pitch must be achieved for quality imaging, though the resulting elements possess
nguishing various tissue types. A number of visualization methods such as elastography and RF analysis have advanced IVUS, though these
their ability to cause anomalous glycosylation of proteins essential to viral/parasite development. Given the role of macrolide glycosylation
ximize the difference between inotropic activity, which could be cardiotoxic, and antitumor activity due to other effects of such glycosides.
mia during transport to the islet isolation and transplant center. Perfusion/preservation technology has been shown to have a major impact
ems. A simple glass disposable slide will be used to prepare and analyze a stained monolayer from a drop of whole blood in seconds, using
icomolar to nanomolar) concentrations, especially on fetal or developing mammals (including humans). The prevalence and actions of EDs
al growth factor (VEGF) plays a pivotal role in the pathogenesis of retinal NV. Targeting VEGF receptor (VEGFR) or disruption of VEGF signali
4). Currently, there is no satisfactory therapy to treat DME and retinal NV but most certainly, a dire need exists. Charlesson, LLC and its wh
F) is believed to play a critical role in DME. Targeting VEGF or the VEGF signaling is believed to be a most promising strategy for pharmacolo
ped countries, leptospirosis is a major public health problem as the cause of substantial morbidity and mortality among subsistence farme
uccessful treatment. The majority of cancer-based gene expression profiling is done using fuorescently labeled nucleic acid microarray tech
minal extension on ACC2 that directs this form of the enzyme to mitochondria. There, ACC2-catalyzed synthesis of malonyl- CoA leads to su
es currently in use for remediation of metal-contaminated water have various limitations in terms of capacity, selectivity and robustness. In
e risk of preterm delivery in asymptomatic pregnant women. Premature softening of the uterine cervix during pregnancy results in prematu
tual environment that gives providers a non-threatening but realistic opportunity to practice cultural skills in a controlled manner, guided b
atient's blood sample onto spatially separate regions on a biosensor chip. Initial capture of macromolecules and cells can be quantified to a
d for improved diagnostics based on biological markers to characterize disease type, status, progression, and response to therapy in autoim
ve, the disease should be detected and treated before the onset of symptoms. Current methods to identify the targets of autoreactive T1D

easy to use and manufacturable. We will call the new electrode SARA (Self Abrading Rapidly Applied electrode). It will reduce three traditio
he system will aid in PD screening and diagnosis, defining diagnostic criteria, and quantifying treatment protocol effects. The objective is to
entering the brain, protecting it from systemic infuences. Unfortunately, bio-defense systems that developed to protect the brain from po
(previously PA-04-064), we propose to further develop and evaluate a unique online intervention for informal (unpaid) caregivers of individ
 high priority for programs educating these physicians. However, based on a survey of the current Emergency Medicine Residency Program
portant clinical target for drug development that has not been addressed by the pharmaceutical industry. Previous studies definitively identi
CAA exist that result from mutations that reside within the Aa peptide sequence of AaPP gene. These include Dutch-type (E22Q) and Iowa
of colitis. We will also define whether there is a dose-dependent response to treatment with COG112 in these models of human disease. T
vere reduction in dopamine concentrations within the brain. PD treatment is currently more like a common cold, with drugs that alleviate s
ated apolipoprotein E polymorphisms in modulating the systemic infammatory response, a response that may play an important role in th
the infammatory phase of the disease, but they do not deliver repair-promoting activity. Therefore, myelin repair may maximize both neu
elop a novel therapeutic drug for MS that interferes with the major infammatory pathways and provides neuroprotection. Our phase I stud
as 62% (Weber 1986). Bone adhesives and cements are currently not used in many of these procedures because they are made from chem
ost-surgical complications, occurring in up to 50% of certain surgical procedures. Traditional wound closure approaches such as sutures pro
accine could result in devastating morbidity, mortality, and economic loss. A dose-sparing adjuvant that enabled a limited supply of vaccine
d phonetic perceptual skills (bottom-up processing) through use of context and general knowledge (top-down processing), even though su

es were shown to be stable up to 130'C and over the whole compositional operating range. Economic evaluations showed the CMS membr

udzu dietary supplements significantly improved glucose tolerance in C57BL/6J-ob/ob mice, an animal model of type 2 diabetes, blunting t

of bilateral CIs, since the assessment of binaural benefits is time consuming and requires special testing facilities. The primary purpose of t
pressure "supersonic pulsed ion beam source, (SPIBS)" recently developed by the principal investigator of this proposal and a miniature fo
cal morbidity and cost issues, psychological symptoms and lowered quality of life are frequent concomitants of chronic pain (Dworkin, Naga
e developed and tested for biomolecular configurations where the Poisson-Boltzmann equation is known to break down, such as highly cha
ng sutures to close and seal wounds. Yet this method can cause severe complications, can weaken the integrity of the eye and may pose a r
when analyzed quantitatively using spectroscopy. Using diffuse refectance spectroscopy, specifically examining the specific visible light ab
currence after simple curettage or intra-lesion excision. Furthermore, segmental bone loss may result from blast injuries, high impact traum

ment and practical requirements to identify, track, and evaluate change in function and disability across older age-groups. To address these
urrently available commercial lift devices become unstable as the client is moved outside the dimensions of the base. LifterMate incorpora
vernments, insurers and several private companies offer information on hospital quality and cost across many conditions and incorporating
nst graded loads while the subject remains seated for safety and comfort. We propose to augment the TRS4000 with functional electrical s

vironmental or work-related chemical exposures, and from pharmaceutical agents such as local anesthetics, acetaminophen, and drugs con

ein from the available bioreactor capacity are deemed critical. Generation of stable high-secreting producer cell lines is a major bottleneck

plete resurfacing of an osteoarthritic femoral head of the human hip joint and proven ability to integrate with bone by using stem cells and
city against melanomas, by augmenting the immune recognition of the melanoma target cells which is essential for lysis to occur. Screenin
poxyeicosatrienoic acids (EETs). Moreover, endogenous EETs injected into the periaqueductal grey area or given intraperitoneally show anti-
ogous cells capable of providing benefit. We have found that human adipose tissue contains cells with properties that suggest potential val
the structure and dynamics of proteins, nucleic acids and their complexes. Nevertheless, a significant fraction of the proteins that are know
d specifically for late adolescents and young adults, ages 16 to 21, with AS/HFA as they transition from high school to post-secondary educa
by improving client confict resolution knowledge, attitudes, and skills. When both Phase I and Phase II are completed, Confict Resolution w
in social, occupational, or other important areas of functioning. Experts believe there are potentially 2.5 million to 11 million people with T
ren constitutes a public health crisis, and access barriers to effective treatments are a major concern (U.S. Department of Health and Huma

million youth who needed addiction treatment received it, leaving an estimated 2.1 million adolescents without assistance (SAMHSA, 200
The data might have factors such as community, family, patient and repeated measures over time nested or crossed in each other. For conti

years today. Yet, the disease remains complex and adolescents with CF experience challenges that can reduce their adherence to treatmen
ent research on BPD treatments, how some families can learn to cope with the disorder and why the outcome for individuals with BPD is m
and boys about general and gender- specific health and safety risks associated with alcohol consumption. This innovative, gender-specific
s are presented to support documenting other tumor models that might be more sensitive. The specific objectives of this Phase I study will

entia patients into a comprehensive training module of all-inclusive strategies aimed at improving sleep for nursing home and assisted livin
ntal and human impacts of such change. In collaboration with the University of Michigan China Data Center and the All China Market Resea
ue, results in less patient trauma, less postoperative pain, better post surgical esthetics, and a more rapid return to normal function. Period
ssible through alcoholic beverage regulatory agency databases. However, the other half of DUI incidents originate in private drinking enviro
om complications. Early diagnosis, referral, and treatment significantly increase the likelihood of recovery. However, only one in ten individu
Herein we describe a new sub-class of RCQ molecules, which we term branched RCQ (bRCQ) molecules. These bRCQ molecules may be ev
fies the nation's older population. This geodemographic approach enables the creation of innovative local area estimates of need, with no
lence for HBV. This simple and inexpensive but highly sensitive rapid test was developed by DRW with funding from the Small Business Inn
iction of disease recurrence and therapeutic monitoring for these devastating diseases. The goal for Phase I of this Project is to optimi
taneously generate an affinity reagent for each identified difference protein. The DCP approach utilizes phage display libraries of peptides f
signed based on usability testing of a cell phone for receiving and sending reminder messages. Adherence assessments will be performed t
ucture. The value of the system is for patients and providers to have an unobtrusive way to gain greater insight into the progression of depr
s targeted to the allosteric regulatory regions of kinases. The technology will measure protein-protein interactions and will employ Discove
velop a novel technology that can be used to discover small molecule growth factor antagonists or agonists. The assay is based on our enzy
oson. This approach will allow 'universal' vectors that could carry any gene and be directed to any cell type without modification of the tran
mortality following transplant using stem cells from an unrelated source. Discovery Genomics, Inc. (DGI) is developing its Sleeping Beauty

quantified. This proposal describes an innovative methodology that has the potential to eradicate noise-induced hearing loss from the work
00, international groups including the World Health Organization launched an initiative to eliminate lymphatic filariasis by conducting mass
a microscope slide in a single sweep at a minimum numerical aperture of NA = 0.65, covering the entire width and length of a glass slide wi
s, they must have a very high probability of binding to the intended sites on the target nucleic acid (e.g., DNA or RNA), but a very low proba
ation dose. There is a need for an independent measurement check on such plans to verify the actual radiation dose delivered by the plan.
ast up to 600 MHz, from the use of cryogenically cooled, circular-polarization RF coils. Examples include mouse and rat-brain H/31P 1 studi
iderable additional progress in such techniques appears likely in the near future. Yet, the fact remains that stationary (non-MAS) high-pow
of samples b) alleviate the need for glovebox preparation manipulations c) allow for in-line sample/solvent delivery. Design enhancements
photodiode array x-ray detectors is compromised by inefficient conversion of x-rays to light, transport of the light to the detector, and con
ared with the basic principles of technology currently used by all major CT manufacturers. The currently commercially-available CT systems

e fow (MMPF) method, a new approach to quantify cerebral autoregulation from nonstationary blood pressure (BP) and cerebral blood fo
ector in which libraries are constructed, to allow screening of large- insert environmental DNA BAC clones in both single and multiple copy
with sub-nanometer level surface finishes and sub-micrometer form accuracies. It is an indispensable machining process for fabricating ult
ry from malnutrition. The collection of infant body composition data can also be used to establish normative databases and help create ge
mation or the patients' underlying conditions or disease. The main objective of the proposed studies is to develop and validate a new assay

our national health and security. All of these issues demand the development of improved toxin sensor technologies. Current mycotoxin d
ociated with an increased risk of systemic complications such as coronary heart disease. The primary etiologic agent of periodontitis, Poryp
of this protein have notably reduced HIV transmission. At present, R&D Systems, Inc. produces this protein in E. coli and sells the product a
olding process that employs a combination of bacterial GroEL and naturally occurring cellular osmolytes. This system is successful at folding
vocabulary learning strategies; and provide multiple opportunities for students to apply their knowledge of word parts and use of learned
 te the means used to induce the ionic current through the pore from the means used to drive DNA translocation through the pore, allowin
gy, molecular biology, and biophysics of ion channels is thus of great medical importance. Channels are also inherently multiscale devices th
continue to grow; it affords a unique business opportunity for the company and is a logical extension of its current business. The proposed
SERS), which allows precise detection of chemicals that adsorb strongly to roughened SERS sensors, like pesticides, into the high ppt range.
ed groups of nanotubes are fabricated as separate wells in the membrane, each group/well derivatized with a different molecular recogniti

el resolution. In ultimate human clinical use, the package would be interfaced with commercial MRI scanners providing physicians with an i
ve for recording that allows educators to get critically needed records without the tedious tasks of manually documenting all of the details
ween eMetagen, an innovative biotechnology company focused on drug discovery and a respected group of natural products chemists at H
response ETC proposes to develop and test a wireless wrist-worn continuous blood pressure monitor that will permit the centralized monit
developing effective ways to use research findings on effective practice in actual policies, strategies and program activities. However, curren
ntion planners, existing analysis and display of these data are typically not useful to the planning process. Available data is collected in non-
to detect icons in a text string and to translate them into control parameters for a formant-type synthesizer, such as the one used in the DE
letely excised to prevent re-excision. To improve care, surgeons are seeking real time information on the tumor margins at the site of excisi
ular bed leading to its obliteration, thereby resolving the neurological symptoms associated. Even though this mode of treatment is genera
ebral aneurysms and is slowly becoming almost the mainstay of care; it generally involves the deployment of metallic microcoils into the an
ree dimensions. Existing synchrotron based microscopes have shown the potential of the soft x-ray microscope as a research tool, but they

vide time- and space-resolved measurements of a wide range of environmental agents. This exposure monitor will significantly improve th
nce tool to support the development of strategies to prevent arsenic-related disease in individuals and population and to help people liver l

ast views to illustrate changes in the neurochemistry and structure of the brain (loss of brain mass) induced by various drugs of abuse. The
man RH transgenes and use them to develop a mouse model of Rh incompatibility, which would have commercial potential in at least three

mation required by health care professionals. The Airfow Perturbation Device (APD) has undergone significant improvements over several
teins, and yet it is small enough to be economical for most laboratories. To date, pronuclear microinjection remains the primary method t
eeding via two tightly- linked enzymes, factor XII (FXII) and plasma kallikrein (PK), may be the mechanism for generation of new thrombin du
antibody screening technologies. The identified clones were too rare for recovery by conventional means lacking the extreme miniaturizati
lignant tumors of the adult central nervous system (CNS). Patients with the disease have a very poor prognosis. Consequently, efforts aime
r enhancement of tear secretion, which would address the primary defect in aqueous deficiency dry eye disease. Compared to current the
an reliably detect and quantitate them at the protein level. Epitome Biosystems has developed a new method for quantitative proteomics
vely complex equipment (cytometers, cell sorters, plate readers) and such equipment needs a controlled environment (machine maintenan
teins. In progress made during the three years of NIH and Sequella/Aeras TB Foundation support, we completed mapping of three sets of T
e therapeutic efficacy, but also requires that FVIII be delivered by invasive routes since less invasive routes are known to further increase th
capillary electrophoresis, the ability of chiral ion mobility spectrometry to examine enantiomeric mixtures is based upon the interaction of
he overall goal of the present grant is to prepare the scientific foundations and an actual prototype of a new generation of breath-analysis e
mplex HIV/AIDS drug therapies for Hispanic and African American populations". MAMS will consistent of a modified miniature battery pow
hese plaques can lead to sudden death through myocardial infarction and stroke. While recent advances in intravascular imaging, including
specific physiological substrates for kinases of interest complicates characterization in intact cells. To overcome this complication, Luna Inno
tissue reconstruction, enhancement, and augmentation; but none is ideal. For this program, the Luna Innovations team proposes to develop

ich catalyzes the de novo synthesis of fatty acids predominantly from dietary carbohydrates. In addition to its expression in human cancers
oduce over two thirds of the worlds naturally derived antibiotics, anticancer agents, and immunosuppressants currently in medical use. Ind
methylmalonyl-CoA node and manipulate these genes and pathways for increased erythromycin production. Many other natural products b
nts. To address this problem, a new bilirubin assay will be developed to determine the plasma concentration of free unconjugated bilirubin
quality of life, require prolonged hospitalization, and may involve infection, gangrene, and amputation. It has been estimated that for each n
he process is such that a single DNA sequence in a genome as complex as the human genome can be targeted. The architecture of the pro
the respiratory and digestive tracts, as well as through the skin. It also tends to have adsorbed chemical species with greater toxicity than

tients. For Phase I, Sehda will create and implement a 2-way speech translation system that will enable nurses at Kaiser Permanente Medic
aining it. In addition, the quantitative reliability of histology is marginal owing to high variability of the stain intensity and color. This Phase
niversity. Based on the success of experiments proposed during the Phase I period, further development of fuorous-based peptide and olig
ersatile drug-screening bench-top electroporation platform to address this ubiquitous need of academic and bio/pharmaceutical researche
ildren to prevent the development of later health risks. The School Success Profile (SSP) for middle and high school students and the Eleme
n the normal range benefit from decreasing their IOP. Currently, numerous pharmacological and surgical approaches are employed to reduc
o take is to develop drugs against host cell gene products that are essential to the productive life cycle of the virus, but not to the host itse
pplications in this powerful medical imaging modality is the so-called parallel imaging method where multiple receive coils are used in sim
or rheumatoid arthritis, wound healing, and male contraception. More than 1.7 million prescriptions for testosterone were written in the U
serotonin (SERT), and dopamine (DAT). Compelling evidence from the clinical literature suggests that remission rates are higher with antide
 ber-missions and the associated cyber-assets. The CORSA environment provides the cyber-mission decision-makers with: a succinct picture
oustic Cloaking Theory,” Proceedings of the Royal Society A, online May 2008, doi: 10.1098/rspa.2008.0076); previous theories based on ex
ncept with a combination of numerical simulations and scaled field tests. We also propose to measure the high frequency ( 1 MHz) acousti
NAR communities, leveraging decades of development effort in that field. The Toolkits will allow for all relevant input parameters (material
onomy offered by the PDE technology itself. Phase I efforts that WAI performed demonstrated that piezoelectric single crystal can meet the
eam to generate signal signature templates for previously unknown signals. The proposed TIPS design is intended to serve three purposes:
nents, materials and construction methods, e.g., steel stud walls, reinforced concrete, concrete masonry units, etc. Step one involves categ
r correction decoding. The waveform class will employ direct sequence pseudo-noise spread spectrum (DS-PNSS) modulation with time-var
of multicast key distribution technologies and will allow the DoD to gain deployment experience with identity-based security, security polic
wer friction and for emergency oil-out lubrication condition. Simulated gear contact testing will be conducted to select potential surface e
ur envisioned BRDA will include 1) a suite of simple, compact, low power sensors, 2) a data acquisition and processing system to integrate m
pplication. Optical data will be inverted to provide compositional information about particle fields.
yment opportunities for unobtrusive surveillance. Accu-MiSTS allows a user to determine the best packaging and enclosure for a given dep
address. Of interest in this SBIR is the development of robust routing strategies to connect MANETs with heterogeneous links. We argue tha
anizations have identified structured modeling technologies and processes (including the evolving Model Driven Architecture®, or MDA®, p
or to sense the uniformity of combustion downstream from the fuel injectors. 3)Measure heat fux through thermal barrier coatings by pair
ssion. During the Phase I effort, a DBF architecture and design trade-off analyses will be conducted and an optimum DBF architecture will b

tion. Once activated, these technologies look for opportunities to steal and leak vital information, and/or disrupt operations at the most c
fforts relating to this igniter will be directed toward predicting ignition and fame spreading characteristics applicable to future Air Force boo
ture of our fire detectors. 802.15.4 is well-suited for our solution as it provides features such as low transmit power (
ient, Robust, and Reconfigurable (Emperor) Radio, a battery-operated radio that can be deployed in wireless sensor network applications.
s, the DoD needs a tactical power distribution architecture that creates a true power grid to: facilitate, automate, and optimize load sharing
ese needs, Williams-Pyro, Inc., proposes to develop an autonomous exterior sensor system triggered exclusively by speech or vehicle noise

ill be given to these configurations’ technical maturity as measured by Technical Readiness Level (TRL), SWAP and cost. XTI will perform a t
lity, dedicated hardware is recommended over processor-intensive solutions with shared-bus architectures, which can diminish performan
njector geometry is more favorable for good mixing. XCOR has developed a 10 N thruster that will be modified with a high expansion vacuu
all and light spark igniter, and just enough gaseous oxygen to permit reliable ignition and stable combustion of the fuel. Nitromethane has l
e performance tradeoffs. In this Phase I SBIR project, Xdot Engineering and Analysis proposes to investigate two innovative approaches for d
of SDRs) in the evaluation and quantification of waveform performance, waveform software porting risks, integration characteristics and ris
ng, using already-secured private funds, a suborbital RLV for commercial applications. This gives AFRL huge potential leverage for ORS tech
rtual environment. It will be compatible and can be integrated with all current visual systems. It provides a new way to solve one of the fun
ents and applications to perform an integrated mission implementing cooperative security policies Specific advancements on the state of t
cts. We propose an innovative approach to address these challenges by introducing abstractions based on a hierarchical set of system secu
oposes an innovative solution to these challenges called Design for Certification. The innovation that lies at the heart of Design for Certific
are. The hyperspectral imager is a compact, low-weight asymmetric anamorphic imaging spectrometer covering the UV through SWIR spec
r the development of a comprehensive tool, this proposal primarily focuses on developing frequency reuse methodologies and the SATCOM
y the user. The tool will allow the users to allocate SATCOM carriers and assess transponder bandwidth for the SATCOM design and evalua
must be daytime. Although the first requirement can be met through careful planning, most military missions necessarily occur under the co
e heavily upon accurate initial condition data. This data can ideally be provided by in-situ dropsonde observations. What is needed is a low
The primary analysis simulation environment will utilize the OPNET Discrete Event Simulator. All three approaches will utilize the same bas
ode type, stabilized electrolyte, binder solubility, stabilized surface coated cathodes, etc) and demonstrate that the combined enhancemen
anical Systems (MEMS) technologies. It will be extensible and allow for future anticipated GPS Modernization improvements, especially the
ch will bring consistently reliable sub-meter dynamic positioning, depth and attitude, full-duplex voice, high-data rate throughput in excess
 urce(s) of TCE. Initially, ZAPATAENGINEERING will offer the methodology as a service to be performed or supervised by ZAPATAENGINEERIN

rometers. A thin sheet of nano-sized powder is spread on a solid surface and the printing roll is rolled over the sheet. The nano-sized pow

than oxides that may release oxygen at inopportune times. The robust covalent bonding of PO43&#8722;, however, reduces the compound

ity metal-air cells. Yardney will advance the Rechargeable Lithium-Air Storage System by creating an advanced rechargeable air cathode wit
ng orbiting scatterometers. During Phase II we propose to develop a model of ocean surface roughness modulation due to interaction of su
tified and will be investigated. These cells produce power by the lithium reacting with the air cathode. This significantly decreases the weig

ral signatures that are separable from narrow water absorption spectral lines using our proposed novel algorithm. Improvements in the em
cess using precision lithographic processes, enabling nL volumes to control mL volumes of liquid in a minute size and at a low cost. • Exploi
inear aeroelastic simulation for complex aircraft configurations. The CEFM solutions will be validated with wind tunnel test data to be obtai
amplitude motions. The promising outcome of Phase I will lead to the success of the proposed Phase II program. Thus, the multi-body-dyn
big RWDs and found that there are 7 serious problems must be overcome: (1) the measurement assumptions and calculating equations ar
molecular signatures but under-utilized for spectral sensing. The Phase I work plan will experimentally demonstrate ICLAS using THz QCLs f
er range for some weapon, which will be vital to our soldier in the battlefield.
discharging) and allow conventional electronic circuits to be used for state-of-charge estimation. These characteristics make the cells espec
or the peak force per unit length to be effective during the entire shuttle deceleration. Both were linearly graded over the length of the edd
deuterium decoration’ process is used in conjunction with Nuclear Resonance analysis it will allow for defect ‘maps’ of ZnCdTe substrates, e
rmal performance, are bulky, buoyant, inhibit dexterity and tactile sensitivity, and are difficult to maintain waterproof. The proposed study

e optics specification and electronics development phases. This increases the probability of successful field acceptance testing and increas
i custom, standard cell, and programmable array integrated circuits. The BICS approach will be characterized and validated against a standa
llustrated the development of a rudimentary database of the polarimetric properties of various surfaces that can be used for surface discri
hile throughput of the laser decoating system will be unaffected. ERCo has demonstrated the technique in its laboratory and has shown th
, stable catalyst will allow clean operation at conditions that favor high efficiency. The method of fuel addition does not require high fuel pr
, first person simulation of the tanker in operation connecting to a customer, and create the functional and architectural definition docume
on their promise of better discrimination of low temperature targets against low temperature backgrounds, and large-format arrays. In Pha
erature and high hydrogen gravimetric density will facilitate the devleopment of a compact, simple and reliable fuel cell generator.
ge-scale proprioceptive inputs require considerable logistics that are extremely difficult in a deployed setting, our team of engineers and cl
airfow generated noise. Phase I activities will involve analyzing the cooling subsystem for noise generation locations, producing novel mate
ell as a poor gait pattern. An uncomfortable or non-performing socket/residual limb interface decreases user compliance with the prostheti
ry of sand and rain erosion tests and is now proposing to develop a boot capable of non-thermal anti-icing/de-icing without requiring elec
soldier heath is the rapid deployment of new technologies that reduce the hindrance of PPE measures and enhance protection against ins
hysical and cognitive effects of long duration wear of the helmets during fight missions, and how that may impact pilot performance. IST h
oration (IST) and Cascade Designs, Inc. (CDI) propose the development of a device capable of providing the USMC and other components o
ntration of PrPsc and high presence of PrPc associated with all blood components and serum even in infectious animals. Any blood diagno
al, Infoscitex proposes the use of a synthetic DNA-based taggant entrapped in a sol-gel material with attributes allowing for covert and secu
We employ a simple method that maintains minimal state information at each router and functions independent of the underlying queuin
on beyond this bone conduction limit. While there remains room for improvement in traditional hearing protection, both active and passiv
xtensible five-point harness belt allows the occupant to rapidly transition from seated to half-standing and to full standing position and pro
0 have been exceeded. Infoscitex proposes to develop a space grade optical bonding technique comprised primarily of a radiation-hardene
matically aligning the raster maps with satellite imagery, and automatically extracting the information contained in a map, such as transporta
the system sensitivity to detect subtle targets (such as dismounts), we propose the use of a nonlinear fight path. A nonlinear fight path al
ps and the associated fastener holes which in turn allows for thinner composite cross sections. Printing or embedding the “wires” in the co
 strated the approach to be rapid, scalable, and economical. The Phase II program is proposed to bring this technology to maturity and tran
ability of the armor system will lead to the generation of lightweight, creative grille designs that would be unattainable with conventional a
th up to 20-GHz bandwidth in the 80-100 GHz band. Radar modes of interest are Micro-Doppler MTI for hovering, SAR resolutions of 10-cm
ology, including extensions, optimization, and continued validation. In Phase II we will also develop a software application integrating the s
between the values of the information produced from the same data. The fact that different groups perform this data-analysis task with va
roblem, Infoscitex applied the Phase I research into evaluating the feasibility of the RAFT (Risk Assessment of Frontline Troops) application,
t and noninvasive volume sensing system designed during the Phase 1 program to determine the volume of water in a collapsible bladder c
n that promises to bridge capability gaps indicative of existing AT solutions. The light-curable anti-tamper coating (LCATC) demonstrated in
e. We have developed a vestibular stimulation protocol that utilizes small amounts of current applied via skin electrodes that can simulate
fuctuations in extreme conditions. By combining a unique coating morphology, rapid deposition process, and substrate-matched thermal
se II base program, additional refinements will be made to the energy harvesting materials and system electronics, thereby increasing its effi
degree. During the Phase I program several iterations of the biomimetic sensor were fabricated and tested, such that the feasibility of the
ositioned to collect ethnographic data prior to large-scale military operations. Because potential or acute political instability is a precursor
here and in an “air breathing” mode. Our work on improving the performance characteristics of the Lithium-oxygen/Lithium-air battery w
the initial attack site and effectively increase survivability of the surrounding cells, dramatically reducing propagation of damage. The mate
o ground troops driving or navigating in a terrain vehicle. The platform needs to fit correctly and accommodate the targeted anthropometri
ources. This energy can be utilized for powering a pump for circulating fuid for cooling a power conversion module. The cold plate for the p
y characterized. FEA thermal models will be developed for a 4 by 4 channel prototype array which will be manufactured for attachment to
in vitro primary human osteoblasts suggest that PC-NSAIDs may have favorable effects on bone remodeling compared with unmodified NS

cuted by experienced metallic fake scientists, Gregory Berube of NanoDynamics and Dr. Dan Goia at Clarkson University. A metallic fake w
stem can be converted into useable electrical energy by thermoelectric devices. An integrated SOFC-TE hybrid, therefore, offers the poten
cies with mass extinction coefficients relative to brass exceeding the target of at least four times that of brass fake. Phase II will demonstra

aveguides to take advantage of their unique fundamental properties of high dispersion and slow group velocity that enable significant enha
ance of bearing and gear fault detection and isolation while simultaneously maintaining or reducing false alarms and missed alarm diagnos
ve concentration of biomaterials from liquid or bioaerosol directly onto coated microstructured arrays. After capture of the biomaterials on
on-board to support Full Authority Digital Engine Control (FADEC) are not only conceivable, but are under active development. Augmentin
ed by a non-inductive technique that employs an externally applied rotating magnetic field (RMF). The RMF directly drives large azimuthal c
eric materials, namely nonlinear absorption, nonlinear refraction and nonlinear scattering. State-of-the-art nonlinear optical (NLO) polyme
advances, a programmable image processor chip, and a high resolution OLED (organic light emitting diode) display. The result will be a sm
is SBIR effort will focus on WMD typing challenges for theater and regional threat scenarios where multiple defensive elements (ABL, SM-3
used to monitor the health of some turbines used at AEDC. IAC proposes to continue to identify key equipment to include in the Industrial M
neously enable order of magnitude improvement in power savings while reducing chipset count, thus size and weight of the radio. The Hy
y first developing welding parameters for smaller diameter wire enabling even finer weld geometry and hence repairs on smaller areas. Th
e designed as part of this Phase I effort will be grounded in best practices for developing critical thinking skills reported in the educational a
neutralize enemy missile attack threats. The proposed models to be developed will allow simulation of impacts by multiple projectiles and
he service life of a military system. POSS, with its nano-SiO molecular structure, has unique properties as a coating that make it environme
e (the Suspended-load Backpack) that not only generates a large amount of electricity, but does so while reducing body forces and reducin
g abstraction and fidelity levels, further restricts the ability to use these analyses in the design process. Coupling these models across disc
rmal condition monitor that can predict the temperatures within an electric machine under healthy and damaged operation, and numerica
ent way to develop predictive models in the absence of a prior sample of degradation signals. This is one of the most significant breakthro
urally strong and impact resistant composites that are optically transparent.
maintaining an acceptably high detection rate, we will explore mechanisms for exploiting scene context. We will also explore methods to o
ovel miniature inertial igniters into thermal battery housing as well as high G hardening are fully addressed. The developed novel miniature
-channel GEM-3 array with a 2.4-m swath; modify the driver electronics for an increased number of channels; increase the sampling rate u
ntegrated architecture, and our research will pioneer Ad-Hoc-MIH specifications. In Phase II, we will develop the proposed approach in a fu
parabolic antennas and dipole arrays.
mesh networks.
esearch gathered in Phase I, Phase II of the TEEM project will create new methodologies, refine previously created methodologies, and crea
efore are not subject to this requirement. Many of these medical shipments are time sensitive and are often subject to damage from rough
d detector arrays. Magnolia team has excellent capability in developing the models for nanostructure based infrared detector arrays, growt
sses and demonstrating compatibility and performance in propellant formulations.
Sample Acquisition System (LSAS) ? that successfully drilled and acquired samples from a variety of rocks and soils including the hardest a
ls (such as gasoline, heavy fuel, kerosene, diesel, propane, coal, cooking oil, and solar) when suitable. The EATR system consists of four ma
igital receiver being concurrently developed under another Army SBIR project.
health, allowing users to ensure that a battery will support a given mission. Finally, we will deploy the NOSTRA system on two real robotic s
agery, but can collect at nadir for higher resolution radiometric imaging. The stringent radiometric and polarimetric calibration procedures
acceleration profiles. Issues related to the integration of the proposed novel miniature electrically initiated inertial igniters into miniature th
on system. Using the differential response of a dual channel system the radial blade tip location is ascertained through two separate pheno
nsidered HAZMATs, or dry-ice sources, which require refrigeration and sublime rapidly. TDA Research, Inc. proposes to fabricate and demon

ured rainbow smelt to supplement and eventually replace wild harvest are increasing. The only obstruction has been developing husbandr
sor development, and earlier pulse-shape analysis and recovery research.
eration (SFG) for 1535nm to 828.5nm up-conversion coupled with inexpensive and very efficient SI-APD technology is expected to significan
or input, mark the location of the anomaly by deploying a small tracking buoy with a satellite modem. The Phase I study will prepare us for
vide a user interface that would guide the user through choosing the appropriate models and data, and provide analysis tools that would a
ons. This proposal addresses these problems through the development of a SLM that is spatially continuous within each spectral line and p
ork from any line voltage worldwide. The Model 8686's intended use is in the standards industry for measuring Platinum Resistance thermo
ely manage open world an closed world reasoning assumptions allows the use of OWL as an expressive schema language for data models. W

ut also the environment. ZigBee RF hot spots placed at known resting or nesting sites for amphibious animals will support unattended read

improve current sensitivity without driving the polynucleotide faster. Electronic Bio Sciences is proposing to develop an alternating curren

ure polytype purity. Various techniques for controlling the diameter, orientation and doping type / concentration of the SiC nanowires will b
op a sensor to quantify CO2 levels in a CCR. The program goal is to demonstrate feasibility of a CO2 specific sensor and demonstrating the a
nifold system that enables automated delivery of standards, cleansers and biocides. Our innovative approaches to profiling, biofouling con
e, the software requires a suite of underwater acoustic source and propagation models. T he interface will embody a seemingly simplistic a

commercial diets on growth rates and feed conversion ratios. Fish from selected cohorts and size class will be tested to determine parenta
ty of the final product. In Phase I, we will (1) demonstrate current capability in gases under 100°C; (2) extend the capability to include aque
pagation in conventional glass fibers is limited by material absorption), the development of new, highly nonlinear materials, and designs th
rehouse (DW) Architecture that can be used to build, manage, deploy, score, and detect anomalies, all within the database. The model and
tivity. We will develop improved annealing procedures to minimize the effects of interlayer magnetic coupling on the new sensor devices, a

ns. T his includes hardening of the rotation hardware, buoyancy chambers and valving, needs identified during our feasibility study. Phase
y used for many husbandry tasks. This project will evaluate a promising way reduce the expense, noise, pollution, and inconvenience of pr
from 18 cm to 23 cm. The demonstrated angular precision is 0.071 arc-seconds (versus the 0.1 arc-second requirement) with a range of +/-
anotubes to provide the sensitivity to detect DNA sequences without the need for PCR amplification of the fish DNA. Comparison of the tw
s will be developed that are ultra-broadband and result in higher finesse values for the VIPA, thus improving spectral bandwidth and resolu
for delivery at the end of Phase I. In addition, the feasibility of integrating the algorithm into the OpenRPG will be examined, as well as int
ys inexpensive surface mount components to implement a standard Stepped Frequency Microwave Radiometer (SFMR) in a small, lightwei
anding of TCs, as well as collecting the necessary information to improve or lead to new satellite-based sensors that can provide observatio
ystem to provide widespread and low-cost access to tools that can be used to generate scenarios of future streamfow. The proposed proj
l at least one in each room of a residence. Sensor modules will be unobtrusive and can be optimized to detect smoldering fires by attaching
tures with a unique adjustable pressure compensator for specimen collection down to 2000 meters. The Techshot High Pressure Specimen
on sensors and arrays will be explored. Smart-cut transfer of domain patterned crystal films on order of a few microns thick to silicon would
oposes to develop a high-resolution alpha spectrometer based on microcalorimeter detectors offering nearly a ten-fold improvement in ene

d circuit rebreahters, one being the lack of a reliable CO2 sensor that can warn the diver when CO2 levels in the loop are becoming too hig
acture lightweight felt barriers that can stop the fame spread, eliminate foam melt through, and be strong enough to handle any water da
Fabry-Perot filters will be immune to the long-term drift and sensitivity to the environment that is plaguing other Fabry-Perot filter designs.

ubes should help validate the expediency and affordability of the high density fathead minnow microarrays for compound screening and u
erally considered to be the cost of project-specific engineering and large-scale construction. The digester in development by Avatar Alterna
sensor employing quantum dot (QD) fuorescence reporters and aptamers labeled with quenching chromophores. Finally, BioTex will dem
for many years to meet the demand. Chip Energy will be a fuels supply company as well as a supplier of gasifier-related technology, hardwa

s that catalytic oxidation is not applicable in most situations, while this approach is.
n and sensitivity. In the Phase I program, the ability to precisely detect an agent degradation product, seven pesticides, and a toxin will be t

identifying, characterizing, and monitoring environmental impact. Specifically, Eon Research hopes to show that microarrays can provide i
into simple sugars and convert them into ethanol are inefficient and constitute the core barrier to producing ethanol at volumes and costs
eliability.
uit and vegetable industries, various canning plants, the poultry industry, the beef processing industry and miscellaneous food processing a
n a fowing stream of water. As part of the proposed studies, a disposable fow cell will be designed and fabricated to implement the innova

t require an external source of hydrogen, and is inexpensive to build and operate. Even with Phase I economics, the KSE technology provid
20 tons per plant. The remaining fines material will have a representative portion removed and submitted to scientists at the Institute of M
MC), to recover water with concomitant energy recovery from these low quality industrial emissions. As a specific example, industrial boilers
sive, thus limiting the utilization of titanium in spite of its most desirable properties of light weight, corrosion resistance, and high mechani

ell the GPSS authentication and registry service. GPSS are business offers that combine product and service aspects of a building product. F
e manufacture of a composite chamber wall of steel-sandwiched Insulfrax, a bio-soluble calcium-magnesium-silicate insulative material des
sive, thus limiting the utilization of titanium in spite of its most desirable properties of light weight, corrosion resistance, and high mechani
e I study of nanotubes should help validate the expediency and affordability of the high density fathead minnow microarrays for compound
n a fowing stream of water. As part of the proposed studies, a disposable fow cell will be designed and fabricated to implement the innova
ell the GPSS authentication and registry service. GPSS are business offers that combine product and service aspects of a building product. F

sensor employing quantum dot (QD) fuorescence reporters and aptamers labeled with quenching chromophores. Finally, BioTex will dem
al technology for identifying, characterizing, and monitoring environmental impact. Specifically, Eon Research hopes to show that microarr
s that catalytic oxidation is not applicable in most situations, while this approach is.

omass into simple sugars and convert them into ethanol are inefficient and constitute the core barrier to producing ethanol at volumes an

nufacture of a composite chamber wall of steel-sandwiched Insulfrax, a bio-soluble calcium-magnesium-silicate insulative material designe
for many years to meet the demand. Chip Energy will be a fuels supply company as well as a supplier of gasifier-related technology, hardwa

n and sensitivity. In the Phase I program, the ability to precisely detect an agent degradation product, seven pesticides, and a toxin will be t

20 tons per plant. The remaining fines material will have a representative portion removed and submitted to scientists at the Institute of M

not require an external source of hydrogen, and is inexpensive to build and operate. Even with Phase I economics, the KSE technology prov
ruit and vegetable industries, various canning plants, the poultry industry, the beef processing industry and miscellaneous food processing
MC), to recover water with concomitant energy recovery from these low quality industrial emissions. As a specific example, industrial boilers
ectronic and artificial intelligence technologies to develop, design, build, and demonstrate a reliable yet rapid wireless fire detector system
dology for characterizing the vibration signatures associated with normal and fault states, for detecting and classifying unknown states thro
We propose new research that will develop and prototype an embedded instrument for aggressive situation security, the CM-Watchdog. T
ment fiber. Ideally it should be a drop-in replacement for currently used fiber. Linden proposes the use of a new class of materials for use as
temperature requirements. A significant worry for engineers at primes is the cost of TKT composite tape and the fact that it has a single su

sed to determine the Imagery Center of Expansion (ICE). Since the scene expands radially away from the velocity vector, the number of ca
cy, high power, wavelength tunability, and excellent beam quality. The objective of this Phase 1 SBIR effort is to assess the feasibility and ro

le, “brownout has been blamed on the loss of more than 20 helicopters and 50 lives since 2001.” This illustrates a compelling need to deve
n. Sensitivity will be primarily limited by vertical surface motion noise and rotations of the vector magnetometer. Areté Associates and Ultr
signed to address the problem. Areté Associates is proud to offer a unique approach to address the detection of sniper optics and neutrali
ar fighter is presented with unprecedented situational awareness capabilities. However, with increased capability come increased demand
e meets those challenges by way of a rigorous 3-D thermal model validated and parameterized with new field experimental data on the the
n concepts fit into the following taxonomical structure: 1) Scanning Seekers, 2) Beam Splitting to Two Sensors, and 3) Focal Plane Arrays of D
he ability to adapt and re-optimize resources and tasks as situations dictate. Through continuous self-modeling and prediction, self-aware,
ment by sensing changes in the target signature (before and after strike) or by measuring a target’s vibration (i.e. engine on or off). Future m
ook analyses to high fidelity simulation. This architecture allows user-selectable control of system models to provide the desired balance b
 s to design two integrated hardware and software systems and demonstrate the feasibility of conducting METOC missions using: 1. a small,
d by outfitting the communications modules with GPS. If deployed on a drifting body the sensor will continuously report its data. Our meth
oise on a small platform to levels equal or superior to current fixed wing MAD systems and have the additional benefit of robust performan
llite sensors. In Phase I, we will determine the expected performance of the methodology by modeling the sensitivity of the Kelvin wave p

n will integrate Vcom3D’s Virtual Human characters and behaviors, as well as Cultural Cognitive Agents developed by Soar Technologies, into
ovided evidence that the system can improvelearning outcomes. For Phase II, Vcom3D creates and evaluates a mobile version of the Signin
applications include coatings for abrasion, ultraviolet radiation and heat protection. Because of their small size, high crystallinity and purit

uilt on top of the open-source Visualization Toolkit (VTK). This library will provide data adapters and analysis routines that run in the same
ages to reports or presentations. While other scientists may gain some insight from these images, they are absent from the process of visua
alth risks from an enhanced greenhouse effect. However, current climate models that couple the physical climate (atmosphere and ocean)
built one prototype system. The prototype monitor met or exceeded all CO2 and CH4 performance targets as defined in the Phase I propos
rly innovative aspect is the prospect of depth resolved lateral strain imaging within and through a ceramic coating. The Phase I work plan co
ts. Lasers and other delicate equipment would be separated from a small measurement head that can be easily protected and manipulated
easibility of developing a framework for interfacing between the sensed data and remaining life prediction, as well as to show the feasibility
d detector/processor unit running dedicated data processing and defect image extraction algorithms developed under this program. The M
tantaneous detection of the complete wavefront formed by the beacon. The proposed approach is based on the analogy between the con
use the sun as a background source have been developed for studying shock waves for aircraft in fight. The application of both schlieren te
s. The only requirement is that H2O molecules must be present in the fow, which is easily met by most rocket plume applications. Because
and theoretical examination then established the feasibility of three separate measurement modules required for inspection. This proposa
MetroLaser demonstrated a technique that enables delivery of enhanced density laser energy to a selected area on a target through a distrib
h different crystallization rates. The particular innovations outlined in this proposal are: (1) the development of new materials that allow sig
n be configured in either direct light or shadowgraph mode. The scanning method is similar to synchroballistic streak photography, and util
lines exposed simultaneously can be controlled by adjusting the entrance slit, which is a necessary feature for focusing schlieren using the
field deployable instrument, based upon integration of customized hardware components and dedicated data processing and handling soft
mentation and techniques for precision metrology are vital for quality assurance. Inspection tools required for these types of optical compo

n methods including SOLA, PSOLA, and WSOLA. We will apply linear scaling factor, which modifies the duration regardless of whether the sp
mation technologies, to develop a voice transformation platform (VTP) and to develop a prototype of a real-time voice transformation syste
roving team geospatial situation awareness via the tactile display. Our solution is grounded by realistic and high-value scenarios and both l

. SONIC builds on social networking capabilities DAC has already built and additionally provides the capability to identify and understand th
eir probability of reacquiring the target is optimal requires the use of algorithms that can fuse all available information into an anticipatory
ptimal estimation theory, and optimal assignment algorithms. Our Phase II emphasis is on obtaining real data for testing and evaluation as
ate elements of our innovative Multiple Hypothesis Bayesian Network framework for discrimination-aided track correlation, making it suita
th the newly incorporated AMR driver. Our innovative solution to the problem delivered significant value to NASA at a relatively small cost
e quality of measurement association, track correlation and fusion of sensor data with large uncertainty (e.g. high-density, passive sensors
any) way that individual component failures can contribute to a system failure. Our models will exploit component reliability data already a
e to express and draw inferences in cases when the facts are uncertain rather than just true or false. The Decisive Analytics Corporation/M
anning tools do little to acknowledge that their plans will be executed by automated engagement managed algorithms. The guidance and
battle command systems are implemented as services that are accessible to the force through the network. With this transformation, how

f financial management and material procurement but no service has effectively addressed depot shop foor automation. While each serv
verhaul at a given time to increase weapon system availability is a challenge DoD has faced increasingly since the launch of the current wa
using the materials; and c) that reduces the barriers to implementation among teachers. To develop, test, and evaluate the product, Advan

p strategies to retrofit the moving baffle to various raceway conditions, and (3) evaluate the performance of the baffle in terms of fish healt

tively impacted the effective management of this important fishery resource. Immediate action is needed for the development of a DNA-b
ry simple test readout. The diagnostic developed will be commercially available for use in Federal, State, public and private laboratories. Th
nally been achieved by adding methanol or a similar chemical to act as the necessary carbon source, which requires sophisticated compute
osts of building and operating the complex systems required for nitrogenous waste removal (biofiltration). We propose to develop and test

ulum that enables high school students to create network models of community issues and institutions in order to increase cognitive skills,

wever, requires much more labor and requires a more regimented production schedule than traditional channel catfish production techniqu
nd queenlessness, 2) expand the concept to discovery of foulbrood, hive beetle, and Africanized bees; and 3) develop algorithms using stati
r their quality management decision making process. This will require the development of inexpensive, easy to install, easy to use, reliable
nancial loss due to the application of timely spoilage mitigation.
emulsions, we have identified a novel iron source, soluble ferric pyrophosphate (SFP), which has promise to overcome the limitations of con

the child’s manner of responding (e.g., response times). The assessment will provide targeted online tutorials that are designed to address
han $1,000 with payback time of seven months. These positive results encouraged industry players to provide key support for Phase II and

g Companion device and application; (2) expand thenumber of mobile communication devices supported; (3) perform an extended usabilit

nformation obtained in a quick and cost-effective manner for the soil in question for improved predictions. In order to test and validate the
his
sednational priority,
on feasibility Farasis
study andEnergy, Inc. tests,
laboratory is proposing
Phase IItowill
develop platform
complete microbial strains
the development capable
by testing ofdemonstrating
and rapidly fermenting the mixed sugars
the technology co
on a farm
educe the nations consumption of fossil fuel, which in turn will reduce the emission of air pollutants, and greenhouse gases that cause glob

evice would enable early detection by farmers at the site of aquaculture by permitting monitoring of brood stock as well as cultured shrimp

s in pigs and the importance of co-expressing PRRSV GP5 and M proteins in protection against PRRS. We have also described a method of p

ation of an improved material for construction of air sampling bags: metalized FEP (Tefon®) films. Utilizing odorous p-cresol as the semi-vo

hat simply cannot exist in nature, often reinforcing incorrect perceptions of molecular systems rather than teaching valid chemical principle
oid future problems with such installations. The shortcomings of conventional direct-buried construction methods can lead to road damag

dynamic medium by creatingturbulence and various other undesirable effects.The proposed saltation sensor is designed as a fat surface em
tive. Real-time, adaptive, control that optimizes the combination, yet provides identical plant productivity, has significant value. Our first go

ay imaging can be repeated on the same plant at different times in its growth cycle to reveal plant root morphology over time in a non-des
ubstrate and container materials. Traditional root system characterization methods, presently used by NCRS, were compared against measu

; data collection, analysis, and reporting; and teacher review and evaluation). Because the students will collect real data, typical measurem

esired mutation should appear in the progeny. The vectors will be derived from a proven geminivirus system in which vector amplification i

type of the design to demonstrate the performance characteristics of the device. The design when completed is anticipated to be ADA-com

anized production and established feasibility of the process. The next steps (in Phase II) will be to refine and further optimize nutritional as

tive of the product producer and from that of the small to medium-sized, agricultural product user.

masses on the earth and the moon to observe the varying effects of gravity or students navigating a freight train to demonstrate resistance

heets that include manure as an absorbent for absorption of liquid oil and aqueous wastes and spills. Bark is an alternative material. The pa
 nly volatile fatty acids can be converted to methane, which is also a fuel. The key advantage of the process is that hydrogen gas can be mad
would be lower than that of other anaerobic systems.
sthtothe
relay information
cloned requiredgene
bacteriophage to set
E. up and maintain
Production of BGthe system.
does VehicleSense
not alter the naturalwill develop
protein a prototype
components low-power,
of the high-resolution
cell, including vehicli
many proteins
uaculture industry. F. psychrophilum BG will be tested for efficacy using a challenge model in trout. The long-term goal of this project is to d

aggressive handling, but did improve buffering capacity in the treated animals, tempering the change in blood pH, resulting in protection ag

Breaking Silo is a project in which universities and law enforcement agencies combine resources in order to create a managed code breakin
ll operate night or day and in adverse weather conditions. The 3D output data will be compatible with commercial software for facial recog
o prevent the emission of interfering gamma-ray lines from other materials. In Phase I an existing neutron generator will be pulsed to produ
rton Electronics, and sonobuoy processing software developed for the Navy by AAC. The Phase I study has indicated that the design will pr
25 lbs and are comprised of separate power units and end effectors connected by a heavy hydraulic line or electrical cable. The complexity
d of malicious use of radiological materials. Analytical software (Patent Pending) evaluates images from security cameras to search for the
DHS requirements. The output will be a recommendation of a phase II device and that can be constructed and tested in the field. The techn
more, its simplicity should help reduce the incidence of sample failure.
figuration of its firmware, software or hardware (VHDL). An immediate benefit of this research will be the availability of tool for the detecti
necessary for a responsive and efficient sample collection system. In this proposal we address two critical areas of a superior collection sys

s a function of the number of sensors in these networks. Moreover, the sensitivity, identification, and localization limitations and the relati
multiple emergency response jurisdictions in the Greater Washington Capital Region to develop a self-organizing wireless body area netwo
ant challenge in homeland security monitoring is not only to detect hidden radioactive materials but also to distinguish them from routinely
represents a promising solution, however, such a detection technique requires capabilities of detecting neutrons while rejecting effectivel
n techniques are useful because the presence of gamma rays of specific energies can confirm the presence of a particular isotope. This tech
s (CNT) possess two unique characteristics suited to this application; they have inherent hydrogen storage capacity and can be used as elec
onex will develop a complete Differential Mobility Spectrometer, DMS, with an integrated CNT ion source. Materials, components and devic
ibitive for most civilian environments. During Phase I of this STTR, Architecture Technology Corporation (ATC) and the University of Minnes
ndous potential of chemistry to modulate their electrical response to specific analytes.
ng braking and steering unaffected. This system will provide law enforcement with a nonlethal tool for stopping vehicles in the safest possi
ll design and develop a proof of concept tool to recover data that has been encrypted with an open source encryption product. The work d
Optima HLS that can fuse data from multiple sources, correlate it, find the root cause, and then automatically notify the required first respo
outside penetration. Instances of SINBAD will be installed between an organization¿s internal network and existing firewall. The SINBAD des
he system then implements prevention rules to deny any botnet communication. While excited about our high quality botnet collections b
range of kinetic energies. Our research has indicated that current vehicle stopping technologies place the user in danger during deploymen

accelerator (linac) system. We will investigate the comparative feasibility and technical merits of S-band (2998 MHz) and X-band (9303 MHz
ry (LLNL). The substrates for these new devices feature a micron-scale topography that is very difficult to coat with existing boron depositio
of hardware and software will provide the DHS with the capability to provide first responders with personal health status monitoring for th
ily be scaled to a variety of larger sampling applications. The system consists of an aerosol spray that is non-contaminating and leaves no re
ates. Since the number of the detected peaks in a multidimensional space may be excessively large, efficient data reduction techniques are

. However, as ICSs are adopting IT solutions to promote corporate connectivity and remote access capabilities, and are being designed and
t is extremely harsh, and the tunnel itself presents challenges to wireless signal transmission. Intelligent Fiber Optics Systems, Corp., IFOS,

figuration of its firmware, software or hardware (VHDL). An immediate benefit of this research will be the availability of tool for the detecti
 e device would provide the same results. Lynntech proposes to design, fabricate, and test a non-lethal, non-tethered, electro-muscular dis
d on density images is insufficient because many non-hazardous items have densities similar to explosive materials. In spite of being highly
overs broad sweep widths from an aircraft at a low resolution and determines potential targets based on a phased averaging algorithm. Th
e, and can be designed to deliver high-energy stun pulses. The Piezer device combines the proven effectiveness, legal and social acceptabi
ission.

gnals from generalized inputs. Our system is novel in that it uses a data fusion framework in which individual features are annotated with st
tiple reactive gases. In addition, we will design and demonstrate methods for improving drift stability through development of sensor fabric
ector system with 252Cf and gamma sources. Together this team can address the difficult challenge of low-fux neutron detection in high g
emblies of nanoparticles as sensing materials. The nanostructure-improved sensing arrays will be capable of addressing some of the existin

ars ago, an advanced betatron design is proposed to provide an affordable, high duty cycle, portable accelerator that would match the requ
on to a simple capacitive probe, it contains a microcontroller-based data acquisition and processing board with digital output. DRAG deter
by a commercial trace-explosives detector. Each complete collection takes approximately 10 s to condense more than 1 L of air. For a trace

lated wavelengths: test and reference. Absorption by explosive particles causes periodical scattering of readout light emitted by LED or inte
ted by aircraft speed or altitude. In Phase I POC will demonstrate the feasibility of HiProWSer with a robust, executable system design and i
return on investment by replacing existing nuclear source gauges with the proposed TD-THz instruments. Nuclear source gauges (such as b

alytes with the material surface. Other metrics to evaluate the materials on the sensor platform are reversibility, baseline stability, and long
l, direct onchip detection; easy to use, compact hardware; minimal sample preparation; < 10 minute assay time; high sensitivity with low fa
ta from real algorithms.
onitor the local hardware and produce an alarm (locally and to any designated entity) if the radiation or the positioning deviates from its b
rototype
e monolithicwillpiece
incorporate
in ordermultiple algorithms
to eliminate for classification
false-positives. As part and correlation,
of this a unique
development effortontology, and an innovative
we will fabricate prototypeuser interface.
detectors. TheWe will
neutro
lications.
he various innovations are required in constructing system architecture and procedures, and to create a standard which is easily and robust
works. As these wireless control systems begin to be used for high-value applications, such as commuter transportation, plant automation, a
al risk due to the improper disposal or damage of these units. Outside the US, there is an estimated additional 25,000 units. TransTech has
s data processing and communications in order to eliminate dependence upon external infrastructure. The envisioned device will support
e confines of a port facility. A successful program will offer increased capability of detecting a terrorist attack on a container enroute, before
egration to detect even low-level or well obscured threat signals. The proposed design uniquely meets the low power consumption, long ba
ough Body-LAN, P2P network and Internet. The proposed second-generation vest will far exceed functionalities of current state-of-the-art
commander
clear researchs institutions.
station. Our solution is easy-to-use (lightweight and small), non-invasive, can be integrated with existing personal protective

experimentally verified the technique on a wide range of explosives and surfaces. The proposed work will combine ERCo s technology with
atmosphere to form a dye that stains the surround of the opening as well as the hands of the perpetrator. Both visible and UV fuorescent
rbulence and areas of stagnation, which cause blood cell damage, lead to thrombus formation and necessitate the use of anticoagulation f

eliminating the need to use a large number of animals. Furthermore, the statistics of the results will be more reliable in serial over parallel
ero may be unrealistic, especially in the near-term as a result of institutional, systemic, and individual factors endemic to the U.S. health car

ollowed by T7 RNA polymerase-based amplification, currently lacks the necessary sensitivity to meet these emerging needs. To overcome th
ign are lightweight, high strength, adjustability and durability. The backrest will be adaptable to most ultralight manual wheelchairs. The ba
chemical structures, similarity-based retrieval of chemical compounds, diversity analysis, and substructure mining. The representation of ch
e they complete their analyses. These protocols are necessary to preserve the confidentiality of the underlying HRS and SSA micro data, wh
ze the beam forming capabilities of the array. AcousTx's experience in novel piezoelectric processing and fabrication techniques will allow f
to eventual blindness. The dry form represents 90% of AMD cases, and there is currently no treatment for it. Although the underlying caus
nvironments. This exposure to environmental toxins plays an important role in aging and oxidation processes, which are key risk factors of
the need for a small pulse width laser pulses when stimulating nerves within the cochlea. In this Phase 2, we propose to develop a compa
RIC, Acumen will establish an infrastructure capable of vastly reducing the costs and burdens that researchers must bear to attain and use C
RIC, Acumen will establish an infrastructure capable of vastly reducing the costs and burdens that researchers must bear to attain and use C
surfaces. However, the preparation of thiol modified carbohydrates required multi-step synthetic manipulations which are difficult and tim
nly surveys of proteins for carbohydrate-binding activities but also elucidation of their ligands. However, there is a lack of technology for th

ed to mimic the anatomical hand, while studies have shown children prefer devices that are more functional. Those who do select more fu
nd Jay Hirsh, where compounds are investigated in rat/mouse models of addiction. The Aims of this proposal entail screening compounds fr
tation as a potential cure for type 1 diabetes has been shown to be a realistic approach with several centers reporting insulin independenc
hracis protective antigen (PA) and were protective against anthrax lethal toxin action in cell-based assays and in animals tests. Since C. perfr
Latency Test) and behavioral tests (e.g. Continuous Performance Test, Psychomotor Vigilance Test) are time-consuming, expensive and ofte
eloped and validated the Apnea Risk Evaluation System (ARES), a convenient, cost-effective alternative to laboratory sleep studies to facilita
the quality of dialysis, and costs significant amount of nursing time and associated resources. Current therapies to prevent or treat symptom
birthing center is impractical. An automated, inexpensive, multi-analyte and multiplexed newborn screening analyzer will help reduce t
th the developed sensors. This application seeks funding to perform FDA required regulatory approvals testing for the developed wire- less
nd to what extent they will take prescribed medications. While computer-based tools allow patients to better manage their chronic conditi
n phase I, AME will identify the most promising dry electrode technology to integrate with the recorder in phase II. The proposed pocket siz
hreatening illness than the general population. Early intervention may mitigate against the development of more severe illness that would li
ging to analyze the effectiveness of the unloading therapy. Image processing software will be used to quantifying of regional changes in cu
rom wearable sensors using a low power standardized digital wireless personal area network technology. The recent commercial availabilit
G applications is a collection of EMG sensors wired to a body-worn amplifier and transmitter device in a star topology. The connecting wires
e I developed prototype system tracked in feasibility experiments with an accuracy of 1 foot (radius). Magnetic anomalies render a magneti
ill be suitable for applications such as high channel count scalp EEG, cortical grid electrodes, multi-contact depth electrodes, and fine wire
ts. Anti-HER2, Herceptin, leads the way for targeted therapy in breast cancer with a definite efficacy in a specific but small subset of patien
tigens (up to 50 if needed) to be assessed in a quantitative manner while preserving the local spatial orientation of the targets relative to t
tastasis occurs. Autoantibody profiling for this important group of circulating tumor markers in peripheral blood has lead us to the identific

irus, which disqualifies from 10 to 50% of batches depending on the vector, means that, as the manufacturing processes are scaled up in l

r type. Thus, clinical Phase Il and Ill studies are needed to evaluate the true potential of AdV-tk. A completed phase I study of AdV4k + pro
on. In addition, carbonyl sulfide has been identified as a possible marker of cystic fibrosis. The simultaneous quantification of these compo
n confidence, and FDA approval. In the near past, MDIs used chlorofuorocarbon (CFC) propellants, but these are in the process of being ph
ponent Qinghaosu (artemisinin) - extracted from sweet wormword (Artemisia annua). The WHO-approved treatment takes the form of a so
ributed an exponential amount of diverse biological information available to the public. The goal of this project is to analyze this data to ge
eived great attention in the media. Yet, while most human sleep loss results from chronic sleep restriction (CSR), most animal studies focus
cognitive tasks, the Morris water maze, the radial-arm and the Barnes mazes in rodents primarily assess spatial memory. Since different be
on and survival. Those cells that survive these challenges will not be fully capable of tissue regeneration unless they integrate appropriatel
ept explantation. New technologies that decrease microbial colonization and infection rates associated with metal implants would clearly b
ever, because of procurement morbidity and constraints on the quantity of autograft, surgeons also use allografts, xenografts, and synthetic
ns, much work has been done to improve alternative grafts with better osteoconductive matrices and exogenous delivery of osteoinductive
ttaches at the wrist (similar to a wrist watch). It will consist of a sensor suite including evaluation and selection of miniaturized gyroscope, a
wn to be an important component of all basement membranes (along with collagen type IV and laminin). There is strong scientific support a
ature. Scientific advancements in the structural and functional understanding of proteoglycans, such as Perlecan, are proposed, along with
e prevalent in science education without fundamentally improving test scores or student attitudes. We claim the core of the problem is how
he individual to environmental factors. Aginova Inc. and Washington University in St. Louis plan to develop a portable personal monitor and
nd InvTool software uniquely offer the capability of rapid development of personal concatenative synthesis voices. With InvTool, individuals

abdominal cramping). Based on a new understanding of opioid receptor pharmacology, AIKO scientists have developed and patented the u
aka's OpenClinica platform, the leading open source clinical research solution, to develop a broad-based open source software infrastructu
ese technologies has the capability to be easily reshaped at the time of surgery. Given the wide range of tissue shapes and sizes encounter
occus pneumoniae (12 pathogens). An array-based approach to respiratory disease diagnosis is recommended because it is difficult to diffe
andemic and emphasizes the need for comprehensive strain sub-typing in surveillance and diagnostic applications. The objective of this Ap
ation, firing patterns, and neuronal secretion in normal, drug-challenged and disease models. Building throughput into highly complex cultu
echnique. Typical optical detection methods include absorbance, fuorescence intensity and polarization, chemiluminescence, fuorescence
nial pressure and abnormal changes in ion transport processes. Neuroproteomic changes in injured patients underlie the complex molecula
ular model, which is the end product of the macromolecular crystallography process. Toward achieving this goal, several novel readouts bas
t isotopes, like hydrogen, deuterium, or lithium. Consequently, neutrons can provide information that would otherwise escape detection b
nd non-invasive cancer after treatment. In this work, we will focus on detecting and imaging hypoxic breast cancer using near-infrared (NIR
ern include imported crayons, imported non-glossy vinyl miniblinds, playground equipment, children's jewelry and clothing. There are regu
ramic, which displays scintillation performance comparable to that of the single crystal, yet is easier to fabricate and could fill the availabili
priate mathematical models. PET imaging can provide diagnosis for symptoms of diseases such as Alzheimer's disease, head trauma, and st
to their slower speed of operation (5 to 30 minutes acquisition time) and limited area coverage. To address these limitations, we propose t
toms of diseases. Nuclear medicine is a very important modality in cardiac imaging, providing both diagnosis as well as prognosis. SPECT is
e high spatial resolution and excellent soft tissue contrast, but suffers from poor signal strength leading to low sensitivity. The overall goal o
ffraction. However, the use of thermal neutrons has been underutilized, partially due to the lack of adequate detectors. Current two-dimen
ct look like? Consider the following sentence from MEDLINE: "Recently, we have found that Htt is an antiapoptotic protein in striatal cells an

of the conventional particle agglutination assays. The proposed immunoassay is a sensitive and rapid method that utilizes inexpensive inst
tion methods to perform anti-D detection and compatibility tests. However, traditional red cell agglutination titering methods have serious
ng progressive neurodegeneration and impaired executive function, and dependence that leads to withdrawal-induced negative affect. Ho
ote resistance. Coatings will be produced by binding the peptide to surfaces in two modes: via a fexible tether and entrapment. A layer of
ly, breast biopsy is neither a benign nor an inexpensive process. Besides affecting patients physically and emotionally, the procedure freque
als directly, independent of oxygen content of the tissue and its cytotoxicity is independent of the dose rate, resulting in potentially power
gures). This promising cancer research must be supported with additional quantities of the isotope if this research is to proceed to later sta
ns, Concanavalin A and jacalin as model analytes to investigate the feasibility of incorporating glycomic tools into its optical platform for mu
h throughput approach for proteomics based on Bead Sorted Libraries of In Vitro Expressed Proteins (BS-LIVE- PRO). These protein libraries
drug-na ve patients. DNA sequencing is the most accurate and comprehensive method currently available for detecting these mutations an
olorectal examination (colonoscopy) either have nominal effectiveness due to low sensitivity (FOBT, PreGen-Plus) or low compliance due to
entifying possible drugs for this disease including the proposed use of statins to alleviate learning disabilities in children with NF1. There is
Since nearly 1,000,000 prostate biopsies are performed each year, nearly 200,000 men each year harbor tumors that escape detection. Th
ed DNA- and RNA-based assays using this technology. The detection of point mutations in a background of wild-type transcripts will provide

extremities in a majority of profoundly disabled chronic stroke patients (>2 yr event). At enrollment, these subjects ranked
suitable both to confer aqueous solubility to GPCRs (as required by solution NMR and X-ray crystallographic methods) and to sustain native
ill demonstrate RHHP in a hospital. RHHP hardware includes sensors to detect soap and gel use and a computer, which both collects and st
h. The NORTECH will be tested in an animal model of diabetic gastroparesis. The proof of concept will constitute studies that include a det
patic regeneration and improve outcome. In a best-case scenario, such therapeutics will accelerate spontaneous regeneration of the liver an
 bility of SF/HGF administration as gene or protein therapy is limited by issues relating to the immune and infammatory responses evoked b
) reliably preserve harvested lungs for 4 to 8hr and do not exploit recent advances in understanding of apoptosis to minimize lung injury du
mor growth, invasion, metastasis and angiogenesis. c-Met, the receptor tyrosine kinase for scatter factor/hepatocyte growth factor (SF/HGF
e current value of lifetime earnings lost $179 million or $300,000 per death. Direct costs are $462 million (32%) or $4,731 per person annua
ymptoms tend to increase in intensity after delivery. RA develops more often than expected the year after giving birth. While women are t
spinal cord, and in peripheral nerves, and has significant potential as a novel therapeutic agent for the treatment of brain and SCI. Adminis
ear. The incidence of brain injury among school aged children has been estimated by the CDC as 90 per 100,000 resulting in the addition o
ecially in the viable tumor tissue. Toward this goal, we have recently developed whole-body imaging systems that enable the visualization o
ll culture is still an impediment to all aspects of HCV studies, particularly the development of HCV anti-viral therapies. The recent developm
psalmotoxin, and an 86-mer, pro-insulin. Preliminary studies and cost projections suggest that peptides ranging from about 8 to 100 amino
en. Our Phase I aim was to demonstrate feasibility by building a preliminary prototype diagnostic that could distinguish AMD patients from
. In particular, PLD2 acts to convert glycerol, which gains intracellular access through the aquaporin transporter channel AQP3, into phosph
ative effects in cancer cells, but it is highly toxic at therapeutic doses. In vitro tests of 1,25-dihydroxyvitamin D3-3-bromoacetate (1,25(OH)2
home assessment system could revolutionize the management of SRBDs, and possibly the management of several other conditions, such a
proliferation, and are known to mediate the effects of vascular endothelial growth factor (VEGF) and tumor necrosis factor-a (TNFa) that ar
lantation, and the rejection of islet allografts irrespective of the use of immunosuppressive drugs. Therefore, the use of islets from a differe
nt of cancer, primarily due to their specificity and ability to induce long lasting immunological memory that may prevent against recurrence
n mechanisms may contribute to this effect. The main objective of this proposal is to develop a novel cancer vaccine for cervical cancer whi
hat modified APMS effectively transfers DNA plasmids to epithelial and mesothelioma cells in vitro. APMS itself is not toxic to cells in vitro
initial hits are difficult to detect because crystals may be small, colorless and disguised by amorphous precipitate material. Most commerci
of the drugs commonly used to induce moderate sedation. The effectiveness of the multimedia training application will be tested using a c
r critical events earlier and diagnose the events more accurately when data is presented in a graphic display. Preliminary studies found that
el was evaluated in the operating room on its ability to predict loss and regain of consciousness and to predict non-responsiveness to noxio
eady hemodynamic aspect of cardiac physiology; to perform parametric studies in order to design new or to improve existing prosthetic va
ed cerebroprotection against experimental stroke without inducing intracerebral hemorrhage. With the Phase I grant support, we will deve
tivation and infammation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered a clot-targetin
ggs for larval identification to species. This application will develop much needed automated vector identification and remote activity mon
henol A), then use the microarrays to measure the gene expression signatures for these compounds. This data, along with a variety of phys
of lung and bronchial cancer are diagnosed each year worldwide, causing approximately 1.1 million deaths annually. Approximately 30% of
ately, this is frequently not the case. Indeed, several studies suggest that many patients do not understand, recall, or even read the consen

amples are fraught with problems, including poor inventory control, poor ability to search inventory without directly accessing samples, co
wledge bases. A knowledge base is a comprehensive database of information, structured in such a manner to optimize data access and ma
ation) is to investigate the use of alginate specific monoclonal antibodies (mAb) as an immunotherapeutic to treat chronic P. aeruginosa lu
re treatment of these diseases is the transport of the enzyme across the BBB. Bypass of the BBB with direct injection into the brain is not e
tforms. We will develop a liquid array system that can accommodate multiplexing levels of 1000-plex or more, and that will be more fexibl
proved training and development of best practices will contribute to the safety and effectiveness of colorectal cancer screening. In addition
tion of angiogenesis would be a useful strategy to a number of ocular diseases in which pathologic angiogenesis plays a role. Retinal neova

of possible cancer treatments and these same imaging/biopsy techniques are often used in mouse models. The ability to biopsy the mouse
d region. Through the use of a customized Fourier transform spectrometer and novel fiber-optic interface, transmission measurements will
This represents a novel approach in biomarker analysis because each organophosphate (OP) pesticide results in a distinct protein "fingerpr
onstrated statistically significant efficacy in the absence or presence of immunosuppression, thereby resolving key clinical issues for using M
o minimize or eliminate pain and distress for animals undergoing painful procedures. The most widely used laboratory animals for various

proposed approach is to create a polymerase chain reaction (PCR) template that contains PCR primer sites that are not present in the targe
mfort. The occlusion effect necessitates that the test ear be uncovered during bone conduction testing. This requires that the tester change
ast one antibiotic, and about 40% of S. aureus infections are multidrug-resistant. Even powerful drugs like Vancomycin and Teicoplanin, whi
to buffer; and 3, test the in vivo pharmacokinetics and the safety of the formulations after implantation into the inner ear of the guinea pig
en is a major cause of graft failure especially in adolescent patients. Pharmacokinetic modeling suggests that periodic subcutaneous dosing
ped a proprietary subcutaneous sustained release platform technology based on suspensions of polymer-coated pure drug particles. High d
The effect of pulmonary fibrosis on quality of life is severe. Currently, there are no effective treatments for pulmonary fibrosis. Hence there
tion of amyloid plaques useful for both 1) Early and definitive diagnosis of AD in the community setting and for 2) Evaluating new therapies
using C-DTBZ, a tracer which binds to the vesicular monoamine transporter (VMAT-2) 11 expressed in beta cells in pancreatic islets. While
r repairing PNS injuries that cannot be repaired by direct coaptation is the use of nerve autograft, however, numerous clinical complication
d weakness that occurs in the legs and hands that is largely due to axonal degeneation in the peripheral nervous system. Peripheral neurop
address this hypothesis we propose to complete the studies in the following specific aims: Specific Aim 1 :- Construction of rBCG that cons
ventional methods such as imaging and neurological examination are often insensitive to mild injury. There is no blood- based diagnostic to
sts. The central objective of the Phase I effort will be to demonstrate the psychometric utility (i.e., validity and reliability) of the proposed n
roximately 5-15% exhibiting major neurodevelopmental disabilities (e.g., cerebral palsy, mental retardation) and an additional 25-50% exhi
mensional chronic pain assessment protocols often require an hour or more to complete. Item response theory (IRT) and computerized ada

poses a Phase I study to evaluate the feasibility of using F-spores to develop a rapid biological indicator for sterility assurance. Critical

the utility of these hardware accelerators is limited by infexible functionality, lack of a clear upgrade path to faster components, and limita
decision-making modules. The programs will use the FRAMES elements common to effective brief interventions. We will also revise the fol
RT stands for Self-Management And Recovery Training. Its web site defines the purpose of the organization as: To support individuals who h
rch design with a nested test-retest component and multisite, multimeasure features will be applied. A stratified sample of middle and hig
atments. BA is an evidence-based practice for major depressive disorder, which may have particular transportability advantages. The propo
sorders at Boston University, where PCT-A was developed and evaluated in a randomized controlled trial (RCT). PCT-A is a cognitive-behavio
ted Ga proteins, has opened up a new avenue for modulating the activity of endogenous and administered GPCR ligands. However, develo
ne that allow quantitative measurement of cell chemotaxis in a defined gradient. Accordingly, the goal of this Phase I proposal is to develo
ays in a high throughput, automated format. The device is a tubeless, automatable array of microfuidic channels for co-culture of mamma
y to develop a HuES based assay that would accelerate the discovery of previously unidentified but required human factors for the generati
sized cancers, including prostate cancer. The incident rate of 232,090 cases of prostate cancer is the highest among all cancers in men, and

rger-than-normal load to the agonist muscles during the LC-phase of the training cycle (LC-only training) can result in greater strength incre
eatments of these diseases. The anatomical similarities between the cardiovascular system of pigs and humans makes them a useful surrog

hods reported this far use microwave irradiation to carry out the reaction, and this method, while usable at the laboratory scale, is not read
n be easily detected by the BFI. These studies found that the electric field can be detected as early as one day after injection of the melano
oping a fully MRI-compatible robotic probe placement system that can be monitored by MRI in real-time, the accuracy and precision of ma
rom federally-funded research, despite a regulation requiring it. In the same vein, researchers often wish to collaborate, but do not becau
ped, and are currently at various stages of clinical testing. Therapeutic inhibition of EGFR has resulted in significant tumor regressions in on
nging task. The overall goal of the Phase I research is to determine the feasibility of commercializing pWGA technology for sale to research
r, ultrafiltration devices. 2. Characterize the operating parameters in terms of the processing time and concentration factor as function of fi
ment. This technology can now be used with most aerobic gram negative/positive species of interest in human health and more than 70 sc
agnose and treat a pneumothorax when an airlift evacuation is considered, as the reduced pressures could result in an expansion of the pn
bsequent global organ damage. The goal of the proposed project is to prevent or reduce the deleterious effects of ischemic damage followi
proposed project is to develop an intracavitary hemostatic agent --Hemostatic Adhesive Foam (HAF) --that promotes hemostasis in cases o
nt. While current state-of-the-art methods allow for integrating datasets that contain spatial or temporal variability, until now datasets exhib
etection of significant discrepancies between health outcomes for different ethnic or racial groups (health disparities), and visualization of
vercome by this project. Local, global and focused tests for residential histories will be developed based on sets of matrices of nearest neig
m objective of this project is to enable physicians to study, diagnose and more clearly understand the response mechanism relating to IOP th
possibly a single cell) with sub-kilobase resolution. Furthermore, the chip will accommodate massively parallel analyses of individual DNA m
al synthesis and purification of peptide antigens, which is expensive and time-consuming. The proposed research will result in the develop
disease, the diagnosis is established by the detection of an antibody response to Borrelia burgdorferi in patients with objective findings su
ures are generally not acceptable to the public. However, if B. burgdorferi could be eliminated from its reservoir hosts and from the ticks tha
ney disease is often under diagnosed resulting in lost opportunities to treat. The importance of early diagnosis and treatment of kidney dis
cells, such as stem cells, transplanted during preclinical research. In Phase I, multi-detection nano- materials were successfully prepared th
offers a noninvasive and potentially less costly alternative. The availability of an effective intravascular contrast agent that can simplify data
ted the discovery of TL1A, a TNF-like cytokine. TL1A mediates cellular effects via its cognate receptor DR3 (death receptor 3). TL1A induces
death but currently no drugs to prevent apoptosis in sepsis are available for clinical use. A soluble decoy receptor, DcR3, has been demons
rometry technology have been successfully demonstrated for human retinal and anterior segment imaging at 830nm and 1300nm wavelen
hase I, BioScale, Inc. and Dr. William Rodriguez of Massachusetts General Hospital (MGH) teamed up to initiate development of an HIV vira
evelopment of two technical components: (A) the high-throughput, economical synthesis of long (30-50 kb) DNAs and (B) the ability to effi
nes limit simultaneous high throughput screening of multiple compounds and signaling pathways. Fluorescence quenched probes are high
potentials and large slow brain field potentials at 24-bit (4096 times greater) resolution making it unnecessary to separately filter the two si
e, by excising speech fragments from a recorded speech data base ("acoustic inventory") and recombining these into output speech using s
ts that may indicate patterns associated with IBD. Furthermore, linkage of our LH-PCR fingerprints to clone sequences show that certain ba

ealth needs demand the development of health communication strategies with increased appeal as well as demonstrated efficacy to reach
onstrated the proof of principal of the components of an aerosol delivery system which addresses the following needs; a) shorter treatmen
ry, environmental microbiology, and homeland security. The focus of this research is to develop and characterize a microbial identification p
alled "tight" glucose control. The integration of continuous glucose monitor readings into an automatic insulin pump control algorithm may
activity within individual live cell in real-time, and also effectively monitoring nucleus morphology of apoptotic cells. This bi-functional cas
, typical success rates for a standard ion channel assay, using, for example, the Q-Patch from Sophion Biosciences, the Port-a-Patch system
ope advances today's state of the art in assistive devices for low vision by automatically searching for, detecting and enhancing target obje
f the glenoid surface is the most difficult part of the procedure, and misalignment of the glenoid implant can lead to implant loosening, acc
es frequent administration and reduces potential efficacy. We propose to create polymer modified interferon-gamma proteins that can be a
proangiogeneic mediators are expressed in RA. One of these mediators in particular, vascular endothelial growth factor (VEGF) appears to
h, it is estimated compensation of aberrations of the eye will require up to 12fm of wavefront compensation (with focus and astigmatism co
ecificity below 25% for PE, thus limiting its usefulness as a rule-out test in the patients who engender the most worry for PE. Although man
nts and catheters are pre-sterilized and inserted or implanted under the most sterile conditions available; biofilm growth, encrustation, and
approaches have shown limited efficacy, since a "cleaned" tooth surface provides an equal opportunity for commensal and pathogenic ba

1. recognition of protein interactions, and 2. characterization of post- translational modifications. Our long-term objective is to solve key a
ronment Initiative, focusing on xenobiotic biotransformation in human disease like Autism. Our BRES will lead to reliable measurements of
n and measurement of CAM adherence by measuring CABs consisting of protein-ligand adducts and protein-metal metabolites with no a p
s have been advanced to explain the basis for ALS: glutamate excitotoxicity, impaired mitochondrial function, oxidative stress and aberrant
protein in the brain may represent a novel approach for treating PD and potentially other related neurodegenerative diseases. Here we pro

ersons at risk for dehydration. In recent years, several researchers have identified salivary osmolality (the concentration of particles in saliv

The Applicants' research is aimed at the further development of CPCs, which were found to exist in humans on the basis of key similaritie
 al efficacy can be inadequate, and more than 20,000 NHL patients die each year, despite treatment. In addition, doxorubicin is limited by d
ver, current cerebral oximeters have yet to achieve their initially expected potential of becoming a routine clinical monitor like pulse oximet
ge students. While a BASICS manual, practitioner training workshop, and demonstration video have been developed to aid program dissem
cord blood cells mononuclear fraction (HUCBC, trademark name "U-CORD-CELLTM"), a well known immunomodulator. This was observed t
tients from a single pancreas donation. The Company has obtained an exclusive license to culture methods developed by Dr. Parenteau (Am
d strategy involving process integration and cellular conditioning is necessary. CPSI intends to apply this novel strategic approach to develop
py IND'S. These same data on stress pathways are also being used to potentiate cell death in cancer cells during ablative freezing processes
sses - a regime that couples traditional cryosurgery with adjuvant (e.g. 5-FU, cisplatin) treatments. This approach has recently led to the ini
quantifying lysine acetylation sites. This method will contribute to the development of drugs that affect protein acetylation levels in cancer

as designed primarily to curate and present information from published literature, which historically focused on one or a few phosphorylati
time consuming human clinical trials. The completion of the Phase II project will enable us to start beta testing with pharmaceutical comp
imetics, and biological validation of specific targets. Despite these successes, application of phage display technology for High Throughput
d genes, allowing for loss-of- function genetic screens in mammalian cells. Despite these successes, high-throughput (HT) RNAi screening i
xperimental tool to specifically reduce expression of targeted genes, allowing for loss-of-function genetic screens in mammalian cells. Desp
production, microbial invasion in the setting of impaired innate immunity and coagulation all contribute to XRT-induced gastrointestinal (GI
ufacturing, which will be used to pack fu virus purification columns. For Phase I study, we will build several 100 mL columns, which will be
and transmission of resistant strains. Monitoring HIV viral load, or the concentration of viral RNA in the plasma, is part of the standard car
nt process produces significant savings for pharmaceutical companies. The market for such screening services is estimated to exceed $113
tifying and verifying prescription medicines at the point of sale (heretofore referred to as the Prescription Verification System, or "PVS"). Cu
oassay system. Centice Corporation's multimodal multiplex Raman spectroscopy engine has successfully been applied to benchtop pharma
h the resulting elements possess a very high electrical impedance and poor matching to electronics. Connection to these elements is difficu
ve advanced IVUS, though these require a large bandwidth transducer. Many existing transducers do not have adequate performance, and
e role of macrolide glycosylation in defining the final antibacterial, antiviral and/or antiparasitic potential of this validated drug scaffold, a si
other effects of such glycosides. We will aim to discover a new drug for cancer treatment by optimizing the novel cardiac neoglycoside lead
en shown to have a major impact in circumventing ischemic injury in kidney transplantation. This proposal seeks to apply this approach to t
f whole blood in seconds, using a novel, new method. The image analysis hardware will use a combination of darkfield and brightfield illum
he prevalence and actions of EDs in our environment warrant the development of valid assay methods. Consequently, various governmenta
FR) or disruption of VEGF signaling is believed to be a most promising strategy for the pharmacological therapy of ocular NV. Therefore, sea
ists. Charlesson, LLC and its wholly-owned subsidiary LifeTrees, LLC are Oklahoma City-based companiesthat are leading the discovery and
omising strategy for pharmacological interventions of DME. Therefore, searching for and developing new drugs to block retinal vascular lea
rtality among subsistence farmers and urban slum dwellers. Because few laboratories are equipped to perform the antiquated microaggluti
eled nucleic acid microarray technologies that are expensive, slow, and sometimes unreliable due to low sensitivity and specificity. Here, a
hesis of malonyl- CoA leads to suppression of fatty acid transport and subsequent oxidation. ACC1- synthesized malonyl-CoA is used for fatt
ity, selectivity and robustness. In this Phase I program, an arsenic selective ligand-anchored fiber adsorbent will be developed as the basis f
ng pregnancy results in premature cervical dilatation (opening) and effacement (thinning), and puts pregnant women at high risk of prema
n a controlled manner, guided by well-validated precepts derived from studies of patients' socio-cultural context and expectations. TEACH
s and cells can be quantified to assess the presence of specific subpopulations of leukocytes, cytokines, antibodies and other immunologica
nd response to therapy in autoimmune diseases. We are proposing to develop an integrated bioanalytical platform and a clinical research p
y the targets of autoreactive T1D-specific T cells are slow, technically demanding, labor- and reagent-intensive, and consume large numbers

ode). It will reduce three traditional steps (skin preparation, electrode preparation and electrode fixation) into a single step. In addition to s
otocol effects. The objective is to develop a multivariate system capable of recording, quantifying, analyzing, and presenting multiple symp
ped to protect the brain from potentially dangerous substances may also contribute to the phenomenon known as multiple drug resistance
mal (unpaid) caregivers of individuals with Alzheimer's disease and other dementias. Research has proven that psychoeducational interventi
ncy Medicine Residency Programs, there is little (28%) or no (67%) training in psychiatric issues (Santucci, Sather & Baker, 2003). To address
revious studies definitively identified CDD-0304 as a lead compound for the treatment of schizophrenia. Continuation of analog synthesis e
ude Dutch-type (E22Q) and Iowa-type (D23N) mutations which cause early and severe cerebral vascular amyloid deposition. Recent studies
hese models of human disease. This course of experiments has the potential to represent a novel therapeutic strategy for a difficult gastroin
n cold, with drugs that alleviate symptoms but do not address the underlying cause of the disease. Unfortunately, this approach does nothi
may play an important role in the outcome of patients with sepsis syndrome where presence of the APOE4 allele is associated with increas
n repair may maximize both neurological and functional restoration, and represents a most attractive strategy for developing a new therap
europrotection. Our phase I study established proof-of-principle with Cognosci's innovative anti- infammatory/neuroprotective ApoE-mime
ecause they are made from chemical compounds that bond bone but do not permit bone regrowth. An ideal adhesive for bone repair shou
e approaches such as sutures provide point-to-point fixation, which is inadequate to fully adhere planar surfaces. What surgeons require is
abled a limited supply of vaccine to protect more people would diminish this problem. We have identified small lipophilic molecules that pe
own processing), even though such strategies cannot guarantee good comprehension. However, popular language training systems focus on

uations showed the CMS membranes to have in excess of 80% capital savings compared to existing drying processes. In addition to work on

del of type 2 diabetes, blunting the rise in blood glucose levels after i.p. or oral administration. Puerarin is rapidly absorbed from the intesti

cilities. The primary purpose of the Phase II research is to complete the development, validation, implementation, and norming of a practic
this proposal and a miniature focusing time-of-fight mass spectrometer (FTOF-MS), also developed by the principal investigator for NASA i
ts of chronic pain (Dworkin, Nagasako, Hetzel, & Farrar, 2001; McBeth, Macfarlane, & Silman, 2002). Precise prevalence figures for clinical p
o break down, such as highly charged biomolecules in multivalent salt environments. In Phase II, this model will be further refined, incorpo
grity of the eye and may pose a risk for ocular rupture in the case of blunt trauma. Other techniques to close wounds, including the use of
mining the specific visible light absorbance at the palpebral conjunctiva, our team has shown that total hemoglobin levels can be measured
blast injuries, high impact trauma, or repeated surgical debridement for treatment of chronic osteomyelitis of the mandible. Surgical excis

er age-groups. To address these deficiencies, the principal aims of Phase I are to: (1) build a prototype computerized adaptive testing (CAT)
of the base. LifterMate incorporates an innovative stabilizing design that allows the movement of the client in three dimensions, which will
any conditions and incorporating a variety of data, process and outcomes quality indicators. However, according to investors, bankers, indus
4000 with functional electrical stimulation (FES), which has the potential to produce the required reciprocal stepping pattern thereby exerc

, acetaminophen, and drugs containing nitrites and/or nitrates. Children, especially those younger than four months of age, are particularl

r cell lines is a major bottleneck, requiring a 4-10 month process with no guarantee of success. Cloning of cells for high expression of a sec

with bone by using stem cells and a cartilage-mimetic scaffold. The two novelties of this work are: (i) accelerated generation of mechanically
ential for lysis to occur. Screening of molecular libraries will be focused on changes in the tumor target cells, but will score all agents which
iven intraperitoneally show anti-nociceptive effects in the tail fick assay with greater potency than morphine. Furthermore, in collaboratio
perties that suggest potential value in autologous vascular cell therapy. However, the identity and mechanism of action of these cells remain
on of the proteins that are known through the analysis of the genomic sequence are inaccessible to standard solution NMR methods. This
school to post-secondary education or work. Individuals with AS/HFA often have difficulty with social interactions, organization, and abstra
completed, Confict Resolution will be a bundled product consisting of the following interrelated components: 1) A facilitator's guide, whic
illion to 11 million people with TTM in the United States (Diefenbach, Reitman, & Williamson, 2000; Tay, Levy, & Metry, 2004). TTM is rarel
Department of Health and Human Services, 2003; U.S. Public Health Service, 2000). The rates of service use tend to be worse for low-incom

ithout assistance (SAMHSA, 2003). Overall, the field lacks research-based, manualized approaches to adolescent substance abuse that can
 r crossed in each other. For continuous response, hierarchical models such as linear mixed-effects models or latent variable models have b

uce their adherence to treatment regimens and undermine their long-term well-being. Poor adherence to complicated life long treatments
ome for individuals with BPD is may be more hopeful than once believed. Using the existing technology of video to address an important an
This innovative, gender-specific approach to alcohol prevention differentiates the MSC curriculum from other alcohol prevention tools for
jectives of this Phase I study will be to: 1. Synthesize 7-butyl-10-aminocamptothecin (BACPT) and its water-soluble dipeptide pro-drug, BAC

r nursing home and assisted living caregivers and home based caregivers in Spanish and English versions. Evaluate the usability, cultural acc
r and the All China Market Research Company, (Beijing, China), the first-ever release of People's Republic of China 2000 Census data at the
eturn to normal function. Periodontal minimally invasive surgery is currently in use but no surgical instrument system exists that allows a su
iginate in private drinking environments, where knowledge of alcohol effects, risks, and legal implications are less well known. In many juri
However, only one in ten individuals receives treatment. Dental professionals play a fundamental role in the secondary prevention (early de
hese bRCQ molecules may be even better than the 'simple' RCQs. The goal of the described project is to understand how to optimize struc
area estimates of need, with no risk to confidentiality. A proprietary, easy-to-use, Internet-based system will make these data available to a
ding from the Small Business Innovation Research (SBIR) program of the National Institutes of Health (NIH). The project is a competing conti
hase I of this Project is to optimize in human plasma a new proteomics technology, Differential Capture Proteomics (DCP), which can identi
age display libraries of peptides from which affinity reagents against the protein components of two samples are isolated. A novel subtracti
assessments will be performed through self-reports from the phone. These self-reports will be validated with a composite adherence meas
ight into the progression of depression, and potential response to therapy. The core technology is the SPIMA index that is calculated based
ractions and will employ DiscoveRx's enzyme fragment complementation (EFC) technology, which consists of a sensitive 2-galactosidase (2-
s. The assay is based on our enzyme fragment complementation (EFC) technology that utilizes two genetically engineered fragments of E. c
without modification of the transposase or transposon for each cellular target. This project will dovetail with DGI's ongoing SBIR project to
s developing its Sleeping Beauty (SB) transposon system as a non- viral vector for gene therapy of FA. The two-component SB system consis

duced hearing loss from the workplace. The doseBusters USA approach to hearing loss prevention involves the continuous monitoring of pe
atic filariasis by conducting mass drug administrations. Although the compounds available for this program (ivermectin, albendazole, diethy
dth and length of a glass slide with 0.23-fm sampling. The optical system is based on an array of miniature microscopes. Each microscope in
NA or RNA), but a very low probability of binding to any other background human or contaminating nucleic acid. While some current tools
tion dose delivered by the plan. The potential technological innovation consists of a translucent, colorless, tissue-equivalent gel that develo
ouse and rat-brain H/31P 1 studies of malignant tumors, brain metabolism in small animals, plaque formations in mouse and rat models of
stationary (non-MAS) high-power methods have been more fruitful thus far in yielding structures of large, complex, helical membrane pro
delivery. Design enhancements should improve ease of use by increasing safety considerations and reducing sample loss risks. Phase II con
he light to the detector, and conversion of the light to electric signal. We have successfully developed a new direct x-ray converter material
mmercially-available CT systems typically use a detector having silicon (Si) (p-n junction) photodiodes that are optically coupled to a scintil

ssure (BP) and cerebral blood fow velocity (BFV) fuctuations using transcranial Doppler ultrasound. The major breakthrough is that the MM
n both single and multiple copy number; (2) To construct an environmental library in the modified BAC vector and to screen for antibiotic a
hining process for fabricating ultraprecision macro- and micro-optics and non-optical components for biomedical products used for biome
ve databases and help create generalized resting energy expenditure prediction formulas for infants. These formulas can then be used to a
evelop and validate a new assay that will enhance the ability of clinicians to detect chronic wound infection earlier and with more accuracy

chnologies. Current mycotoxin detection methods (e.g., those based on antibodies) have practical shortcomings both in the development o
ogic agent of periodontitis, Poryphyromonas gingivalis, is closely associated with the onset of periodontal disease. This bacterium, along wi
in E. coli and sells the product at a cost of approximately $2.5 million per gram, which restricts its use. The high cost associated with SLPI r
his system is successful at folding a number of proteins that cannot fold from either the chaperonin or osmolytes alone. The chaperonin/os
f word parts and use of learned strategies to high frequency academic vocabulary. Validated instructional principles such as detailed descri
 cation through the pore, allowing each to be optimized separately. In Phase I the key questions relating to the second innovation will be in
o inherently multiscale devices that link atomic scale structures to macroscopic fows responding to single molecules with substantial curre
s current business. The proposed products to be researched in this Phase II SBIR are "hands- on" health-related and life science-related exp
sticides, into the high ppt range. The SERS sensors, vapor deposited gold films with subsequent electrochemical roughening, are inexpensiv
th a different molecular recognition agent (MRA), such as an antibody. In operation, an array would be spotted first in each well with MRAs

ers providing physicians with an immediately available diagnostic tool at the end of the scanning session. The main target market for this pa
y documenting all of the details and without 100% video recording. In phase I, we modified our preliminary system for use in a school envir
f natural products chemists at Harvard Medical School led by Prof. Jon Clardy and Dr. Frank C. Schroeder. eMetagen applies patented, cultiv
will permit the centralized monitoring of patients undergoing dialysis. The device is non-occlusive and utilizes a novel physical model of the
ogram activities. However, current reliance on model programs has been fraught with difficulty of application, and by resistance in acceptan
vailable data is collected in non- uniform formats and varying time intervals, and often aggregated at levels too inclusive for local planning
r, such as the one used in the DECtalk Text-To-Speech system. A user enters icons along with text or symbols into an AAC device and the VG
umor margins at the site of excision. Prior intraoperative solutions (frozen section and cytology) to prevent re-excision have not been adopt
his mode of treatment is generally regarded as a better alternative to surgical resection and radiosurgery, there are major limitations and ri
of metallic microcoils into the aneurysm dome through a catheter. Theoretically, aneurysm embolization is achieved via coils that induce ar
cope as a research tool, but they have the disadvantage of being tied to a massive light source at only a few national laboratories. A suitabl

nitor will significantly improve the ability to localize exposure events in space and time and will provide a critical tool for use in resolving un
ulation and to help people liver longer, healthier lives, a key aspect of the mission of NIEHS. We envision this technology also having a role

by various drugs of abuse. The models will be presented on autostereoscopic 3-D displays, which provide the same "virtual reality" visual
mercial potential in at least three areas: 1) Development of alternative therapies for treatment of Rh hemolytic disease of the newborn (HD

cant improvements over several years. APD is simple in concept, employing a rotating wheel in the fow path to change fow by 20-45%, wit
n remains the primary method to produce transgenic rabbits. There are no germline competent rabbit embryonic stem (rbES) cell lines ava
r generation of new thrombin during fibrinolysis. Mice deficient in FXII are highly resistant to the formation of occluding arterial thrombi in
acking the extreme miniaturization of the Trellis approach (100,000 fold reduction). The present Phase II request for funding is to enable ex
nosis. Consequently, efforts aimed at developing new therapies have focused on new treatment strategies that can maximize anti-tumor eff
sease. Compared to current therapy, lacritin, a stable, novel human tear glycoprotein, has a unique mechanism of action based upon its an
hod for quantitative proteomics that utilizes antibodies developed against unique continuous linear peptide sequences (EpiTagTMs) found
nvironment (machine maintenance in high humidity and non-standard temperature environments is problematic). This proposal is aimed a
leted mapping of three sets of TB epitopes including novel epitopes predicted directly from the TB CDC1551 genome. In the next phase of
are known to further increase the immunogenicity of therapeutic proteins. To address this problem, it is necessary to develop a less immun
is based upon the interaction of analytes with neutral chiral modifiers. The ultimate goal of the research proposed is to develop and comm
w generation of breath-analysis equipment and software to address the public health needs of the twenty-first century. This proposal descr
modified miniature battery powered gas chromatograph (mGC) capable of detecting the presence of a "taggant" or a metabolite of the tag
intravascular imaging, including magnetic resonance imaging (MRI), have aided in plaque identification, newer imaging and diagnostic mod
ome this complication, Luna Innovations, the University of Virginia and Harvard Medical School propose to develop cell lines stably express
ations team proposes to develop an innovative approach to effective and reproducible autologous free fat transplantation for use in the re

its expression in human cancers, our collaborators have found that FAS circulates at high levels in the blood of colon, breast, lung, ovarian,
ants currently in medical use. Industrial metabolic engineering also benefits from technical progress made in microfermentation screening.
n. Many other natural products besides erythromycin are made from methylmalonyl-CoA precursors, therefore the information gained from
n of free unconjugated bilirubin (UCB), which is a better indicator of risk for neurological damage. In Phase I of this project, a UCB-specific p
as been estimated that for each new foot ulcer the attributable cost for a middle-aged diabetic man in the first two years is approximately $
eted. The architecture of the process, however, allows it to discriminate against single nucleotide changes with the effectiveness of small du
pecies with greater toxicity than its natural counterparts. The explosive growth of nanotechnology in research and consumer products (sun

ses at Kaiser Permanente Medical Center in San Francisco to communicate with Spanish speaking patients for five common patient-care ac
n intensity and color. This Phase I SBIR application aims for a quantum leap forward in tissue assessment, which will be realized by combini
fuorous-based peptide and oligosaccharide synthesis and microarray formation are proposed for the Phase II period. The specific aims of
d bio/pharmaceutical researchers. Our system - developed solely from the Phase 1 grant -- includes a control interface, with disposable 96
h school students and the Elementary School Success Profile (ESSP) for 3rd, 4th, and 5th graders are designed to help schools respond app
proaches are employed to reduce IOP in glaucoma patients. However, drug treated patients are frequently non- compliant, refractory and/
he virus, but not to the host itself. These antiviral targets are potentially broad spectrum against both the wild type and the mutated drug r
tiple receive coils are used in simultaneous signal processing to speed up imaging. The ability to reduce imaging time by a factor of 4 or mor
stosterone were written in the United States in 2002, representing a 30% increase over that prescribed in 2001 and a 170% increase from t
sion rates are higher with antidepressants that block re-uptake of both norepinephrine and serotonin. While low dopamine has been impli
n-makers with: a succinct picture of the adversarial activity on the cyber-network; the capability to analyze the impact of the adversarial ac
6); previous theories based on extensions of electromagnetics are not physically realizable. Consequently, we propose to conduct extensive
high frequency ( 1 MHz) acoustic environment during the field tests. Quantifying this environment is required to evaluate the potential for
evant input parameters (materials, dimensions etc) to be varied, while calculating and displaying all key output metrics such as electrical im
ectric single crystal can meet the needs of the future fuel injector actuators, displaying greater force output and over twice the stroke of co
tended to serve three purposes: 1) a development platform for real-time template generation algorithms; 2) a fielded first-article template
nits, etc. Step one involves categorizing and simplifying the variety of possible loading wave forms and parametrizing them for use as loadi
PNSS) modulation with time-varying characteristics to inhibit an adversary’s ability to detect, disrupt, intercept or exploit the transmission
tity-based security, security policy distribution, location management, local name servers and certificate management databases in operati
ted to select potential surface enhancement technologies for process development. Surface enhanced gears are a deliverable for Phase III
processing system to integrate measurement streams and apply a simple radiative transfer algorithm to determine bioluminescence detec

ng and enclosure for a given deployment, optimizing the external package towards environmentally inconspicuous arrangement. Williams-
eterogeneous links. We argue that an inter-domain routing framework for MANETs must consider attributes of individual networks to choos
riven Architecture®, or MDA®, process supported by commercial industry) as having a high potential to significantly mitigate the identified
thermal barrier coatings by pairing the proposed wireless temperature sensor (for the surface temperature measurement of TBC’s) with a
optimum DBF architecture will be selected. In addition, the Phase II work plan, which includes the DBF steering of a 4x4 array of horns, wi

disrupt operations at the most critical time. Current solutions fall short in detecting malware information leakage behavior post infection.
pplicable to future Air Force booster and upper stage engines.

ss sensor network applications. Our solution includes implementing innovative power management, developing ultra-low-power software
omate, and optimize load sharing between generators; simplify and standardize tactical power distribution equipment; operate seamlessly
sively by speech or vehicle noise, for alerting security personnel of possible break-in or trespass in military facilities. This network of portab

AP and cost. XTI will perform a trade study to select the best configuration or configurations to meet a minimum spur-free dynamic range
, which can diminish performance. X-COM's knowledge and experience from similar R&D efforts are detailed to demonstrate the effectiven
fied with a high expansion vacuum nozzle and partial radiative cooling for this application. The technical objectives of the Phase I program
n of the fuel. Nitromethane has long been recognized as a high performance monopropellant, but is too sensitive for real-world tactical han
two innovative approaches for directly reducing these windage losses. The first is especially relevant to switched-reluctance machines suc
ntegration characteristics and risk impacts associated with the interaction of waveform software, radio platform services and devices, and C
e potential leverage for ORS technology development and demonstration in several distinct ways. First, some of the final development work
new way to solve one of the fundamental and common problems in VR: users are completely cut-off from real world view; and in AR: com
c advancements on the state of the art are realized through: (a) concepts for a formal process for analysis that is developed with a model-b
a hierarchical set of system security properties that describe the system at the infrastructure, architecture and application levels. The resu
t the heart of Design for Certification is a model-driven engineering approach that integrates the information and analyses required to sup
ering the UV through SWIR spectral regions The proposed system will optimize the hyperspectral data set so that critical information can b
methodologies and the SATCOM analysis. In particular, Navy’s legacy UHF SATCOM operation on MUOS will be analyzed in detail. The pro
r the SATCOM design and evaluation for the acquisition process. To evaluate the network performances, the toolset provides a high-fidelity
ns necessarily occur under the cover of nightfall, where such imaging methods are unusable. We describe a portable passive CCD imager in
ations. What is needed is a low cost and reliable mechanism to enable more routine at-sea soundings. We propose to develop a highly rug
roaches will utilize the same basic framework, where the airborne backbone network is constructed as a medium fidelity representation, so
that the combined enhancements will significantly improve the upper operating temperature. These improvements will also result in an ab
on improvements, especially the evolution of military P(Y) capable devices to support M-Code. Components of the test system will closely
h-data rate throughput in excess of ten (10) hertz, and the ability to track horizontal and vertical position even in the total absence of GPS.
 upervised by ZAPATAENGINEERING personnel. This service dovetails nicely with the other numerous engineering and environmental servic

the sheet. The nano-sized powder is compressed into the cavities and forms a compacted particle the size of the cavity. The compacted p

however, reduces the compounds’ ionic conductivities, and olivines require additional treatment with conductive aids to perform at reason

ced rechargeable air cathode with new catalysts, and testing these cathodes in actual lithium-air cells under various environmental conditio
dulation due to interaction of surface waves with subsurface currents and turbulent wind; to demonstrate the feasibility of detection of su
significantly decreases the weight by consuming oxygen from the air. Yardney’s experience and technologies in oxygen cathodes and powe

orithm. Improvements in the emitter, detector and software will significantly improve the signal/noise ratio of the device by at least two or
e size and at a low cost. • Exploits “muscle wire” actuation technology which brings weight down to < 20g. • Uses a closed system filled wi
wind tunnel test data to be obtained by Duke University with an existing model of typical airfoil section at various FP angle and AoA under g
gram. Thus, the multi-body-dynamics wing modeling will be extended to include distributed and local nonlinearities for morphing wings su
ons and calculating equations are questionable, (2) it is impossible to measure the defection at the same point in the two-step and two-po
monstrate ICLAS using THz QCLs for the first time. This demonstration will utilize the relevant low-vapor pressure explosive TNT. In addition

racteristics make the cells especially well-suited for the smart, lithium-ion, rechargeable BB-2590 battery. The work proposed here will le
raded over the length of the eddy current conducting spear while the PM magnets remained stationary. The geometry of the Eddy Brake is
ct ‘maps’ of ZnCdTe substrates, epilayer/buffer ZnCdTe and HgCdTe films to be obtained non-destructively. The impact that this technology,
waterproof. The proposed study will develop a multifunctional passive thermal protection solution for diver’s hands featuring augmented a

d acceptance testing and increases chances for system deployment without major redesign effort.
ed and validated against a standard set of metrics, including design, area overhead, performance, and power consumption, and will determ
hat can be used for surface discrimination and object recognition using a PLADAR system. Under the Phase II project, we will develop furth
its laboratory and has shown that very accurate coating removal can be obtained. In Phase I, ERCo will demonstrate the device’s ability to
tion does not require high fuel pressure or exotic hardware. The design results in full combustion with clean exhaust. The final packaged de
architectural definition documents for the command and control and integrated health management systems.
s, and large-format arrays. In Phase I, hydrogenation proved effective in passivating defects in MBE-grown HgCdTe/ZnCdTe diodes. Amethys
iable fuel cell generator.
ng, our team of engineers and clinicians has been developing a vestibular display that, combined with visual stimulation, accounts for most
locations, producing novel materials with enhanced absorption capabilities, performing acoustic tests on materials, and developing a desig
er compliance with the prosthetic and therefore decreases the activity level of amputees who want to remain active in their civilian and m
/de-icing without requiring electric power. This is accomplished by incorporating both a non-toxic freezing point depressant additive (
d enhance protection against insects that transmit disease. In this Phase II program, Infoscitex will continue development of a new controll
impact pilot performance. IST has assembled a distinguished team to address this proposal. We are proposing a novel approach to meetin
USMC and other components of the DoD with a disinfecting solution derived from non-hazardous precursors that are air-transportable, sh
tious animals. Any blood diagnostic test would need to discriminate pg/mL concentrations of PrPsc from PrPc. To address the need for ante
utes allowing for covert and secure labeling. This proposed material can be created using a combination of current technologies integrated
endent of the underlying queuing mechanism at the routers. IST has assembled a distinguished team to address this proposal. In conjunctio
otection, both active and passive, a considerably larger gain in nearer terms can be realized by turning our attention to bone-coupled noise
to full standing position and provides security to aircrew while reaching out of the aircraft to perform mission duties. (e) A seat cushion wit
primarily of a radiation-hardened silicate-like network combined with elastomeric linkages. The proposed silicate-elastomer hybrid bond (S
ned in a map, such as transportation networks, hydrographic layers, and the textual labels on the information. The resulting technology w
t path. A nonlinear fight path also improves the system capability to detect targets that move at variety of directions. This in turn provides
embedding the “wires” in the composite also provides support along their entire length which enables wires to be sized solely by current re
 technology to maturity and transfer to end users in the US DOD and civilian industries. The commercialization effort has been started in Ph
nattainable with conventional armor materials in an economical fashion. The Phase II base period will culminate in the validation of the ar
overing, SAR resolutions of 10-cm, 3-cm and 1-cm from hi speed fite, and multibeam communications. The Phase I tradeoff effort will ena
ware application integrating the statistical mobility prediction and visualization methods.
rm this data-analysis task with various levels of success, suggests that advances in this area are possible, even beyond the level currently ac
of Frontline Troops) application, which has at its core a Bayesian Belief Network approach to risk assessment that is based on the input of,
f water in a collapsible bladder canteen, in conjunction with our manufacturing partner. The information calculated by our system is prese
coating (LCATC) demonstrated in Phase I will be refined to ensure protection against a range of reverse engineering techniques. An applica
kin electrodes that can simulate motion in stationary individuals. We will establish the use of this protocol to cancel the unwanted effects
and substrate-matched thermal properties, the ERC system promotes excellent adhesion, prevents stress buildup, and eliminates high-cycle
ctronics, thereby increasing its efficiency and power output. Further development of the propulsion system will be conducted to increase t
d, such that the feasibility of the system was established and a complete sensor package design created. In Phase II complete sensor packa
political instability is a precursor to United States military involvement in foreign countries, the proposed methodology is informed by both
um-oxygen/Lithium-air battery will focus on the implementation of a solid state, Lithium ion electrolyte in the battery to provide a stable int
opagation of damage. The materials-based countermeasures will not require external power, respond almost instantaneously and have m
date the targeted anthropometric range of heads so it is comfortable and stable while NVGs are in use. Factors such as NVG weight, distribu
module. The cold plate for the power conversion module can also be made from this high thermal conductivity material and can be optimi
manufactured for attachment to T/R module emulators and evaluated by a prime contractor partner for thermal performance. The goal is
g compared with unmodified NSAIDs Based upon these studies, we propose to investigate in Phase II the therapeutic actions of the most e

son University. A metallic fake will be developed leading to a Figure of Merit of at least four using a process allowing for easy scalability to
brid, therefore, offers the potential of increased efficiency (lower fuel consumption) than a conventional SOFC. This project proposes a pa
ss fake. Phase II will demonstrate a process that can be used for commercial scale production, as well as address dissemination issues nee

ocity that enable significant enhancement of nonlinear optical effect, and 2) NLO polymeric materials to take advantage of their superior EO
alarms and missed alarm diagnosis in a test rig environment. This type of integrated monitoring system has not been fully demonstrated on
er capture of the biomaterials onto the micropillars, the next step is an ionized gas (or plasma) treatment for about a minute to extract nucl
active development. Augmenting future FADEC systems with real-time PHM sensor integration, data fusion and decision support algorithm
F directly drives large azimuthal currents in the plasma, which together with the radial component of a steady applied magnetic field produ
t nonlinear optical (NLO) polymers will be used as the optical limiting materials in coupled cavity, photonic band gap, and nonlinear photon
) display. The result will be a small binocular device that is expected to provide about 105° by 50° FOV with resolution roughly comparable
e defensive elements (ABL, SM-3, THAAD, PAC-3) may have opportunities for threat engagement. The capability to confidently confirm that
ment to include in the Industrial Monitoring solution. Software improvements and new sensor technologies will also be considered to suppo
and weight of the radio. The HyperX processor technology is fully programmable and reconfigurable on the fy and is supported by industr
nce repairs on smaller areas. Then, a novel monitoring and control methodology known as In – Process quality Assurance – IPQA – will be
ills reported in the educational and training literature.
pacts by multiple projectiles and the effects of Fragment Flood Loading (FFL) during impacts in trial interaction scenarios between new can
a coating that make it environmentally stable, an excellent moisture barrier, and nonvolatile. These unique properties of the POSS feed stoc
educing body forces and reducing metabolic cost. Several major roadblocks were addressed during Phase I, and the primary objective of Ph
oupling these models across disciplines presents additional challenges since they often have different levels of abstraction and may not sha
amaged operation, and numerical simulation tools that enable rapid development and solution of component and system-level models of e
of the most significant breakthroughs of this research effort. The feasibility was demonstrated analytically and through an experimental s

e will also explore methods to obtain useful context. Our primary technical objectives in Phase II include developing a pedestrian detection
. The developed novel miniature igniter concepts are very simple in design and manufacture, occupy very small volume, and are purely me
els; increase the sampling rate up to 750 Hz for higher vehicle speeds; conduct indoor/outdoor tests at Geophex; develop and build, in co-o
op the proposed approach in a full-fedged manner by researching the unique challenges in routing imposed by multi-radio/multi-channel m
created methodologies, and create a strategy for implementation in ground soldier simulation programs.
en subject to damage from rough handling and/or environmental exposure. Very often the timely delivery of these items, in good condition
d infrared detector arrays, growth, fabrication and characterization of oriented carbon nanostructures for IR applications. Magnolia plans to

and soils including the hardest anticipated Martian rock (basalt) and frozen soil not only in ambient conditions but also in a thermal/vacuum
EATR system consists of four main subsystems: (1) an autonomous intelligent control system and sensors; (2) a manipulator system consisti

TRA system on two real robotic systems, the iRobot PackBot 510 and the iRobot Roomba 550, to demonstrate the systems ability to provide
arimetric calibration procedures that are required for polarimetric imaging have been developed, and the associated hardware has been d
inertial igniters into miniature thermal battery housings of various geometries as well as high G hardening are addressed. The project invol
ned through two separate phenomena.
roposes to fabricate and demonstrate the performance of an automated chemical gas generator that will supply CO2 to vector surveillance

n has been developing husbandry methods and processes for this species. Our 2006 Phase I research project proved the feasibility and met

hnology is expected to significantly increase single photon detection efficiency while maintaining long fiber optic transmission distance for
Phase I study will prepare us for a future Phase II program of building and testing the Unmanned Aerial System for operations from a smal
ovide analysis tools that would allow the user to determine the statistical nature of the acoustic problem being analyzed. As part of this pro
s within each spectral line and provides analog intensity modulation using liquid crystal (LC) technology. The SLM will be designed for use in
uring Platinum Resistance thermometers on the International temperature scale 1990 (ITS-90).
ema language for data models. We further propose to consider the applicability of existing description logic explanation and debugging ser

mals will support unattended reading of data from tags while the tag remains on the animal. Solar power supports indefinite endurance an

to develop an alternating current (AC) measurement system with the lowest noise achievable today. With an AC measurement system it is p

ration of the SiC nanowires will be explored. Several strategies for patterning the nanowires on specific locations on the substrates will be i
c sensor and demonstrating the ability to accurately monitor up to 5% CO2 in real time. Our approach to develop the proposed CO2 sensor
aches to profiling, biofouling control, sensor cleaning, and automated calibration are the keys to this device and were successfully demonst
embody a seemingly simplistic and guided approach to enable a user without highly specialized knowledge to select appropriate model in

be tested to determine parentage, leading to better understanding of spawning behavior, larval fitness and genetic diversity of offspring.
nd the capability to include aqueous solutions up to 85°C (3) fabricate new candidate crystal sensors from quartz, gallium phosphate and la
nlinear materials, and designs that allow for mode confinement within the fiber. Mesa Photonics, LLC, and Prof. Fiorenzo Omenetto of Tufts
hin the database. The model and approach described in this proposal will be adopted to build a prototype using the capabilities of a numbe
ng on the new sensor devices, and to linearize the sensor transfer curves. If suitable high-frequency noise characteristics are demonstrated

ring our feasibility study. Phase II funding will also enable OFT to develop custom electronics for the control system and create a versatile g
ollution, and inconvenience of present methods of providing compressed air. A wave-powered system will be designed and tested to evalua
requirement) with a range of +/- 50 arc-seconds. The Phase I work will build and test a prototype interferometer which will confirm the des
fish DNA. Comparison of the two detection methods as part of this work will be used to select the method to be implemented in the Phas
ng spectral bandwidth and resolution. Improvements to the VIPA optical surface geometries will result in more narrow linewidths and bette
G will be examined, as well as integrating lightning detection network data to improve the nowcasting capabilities of the algorithm, using Nu
meter (SFMR) in a small, lightweight package. In Phase II, we plan to develop a single sideband version of the CCR receiver module that is d
nsors that can provide observations of TCs on a global scale. This proposed effort seeks to realize an Internet-based radar digital receiver an
streamfow. The proposed project will determine the feasibility of developing a prototype web-based Climate Change Drought Decision S
ect smoldering fires by attaching directly to furniture particularly for high risk residents including young children, the elderly, and the physi
echshot High Pressure Specimen Chamber is an intuitive, user-friendly system allowing for easy pre and post containment operation by hum
ew microns thick to silicon would enable formation of uniform large area pyroelectric detector arrays that are at the same time ten times m
ly a ten-fold improvement in energy resolution, thereby enabling the detection of minute isotopic compositional difference in sensitive nuc

n the loop are becoming too high. Currently, divers must rely on training and experience to identify when conditions are becoming unsafe.
enough to handle any water damage.
other Fabry-Perot filter designs.

s for compound screening and use in environmental toxicology.

n development by Avatar Alternative Energy addresses these concerns with the following design features: The digester is modular and can b
ophores. Finally, BioTex will demonstrate the sensitivity and specificity of the novel sensing chemistry for field and laboratory use.
sifier-related technology, hardware, and service. Appropriate environmental protection will be a high priority.

n pesticides, and a toxin will be tested in water samples in the presence of various natural interferences. During the Phase II program, the S

w that microarrays can provide information on the degree of environmental impact and the identity and effects of multiple contaminants in
ng ethanol at volumes and costs competitive with gasoline. This project seeks to demonstrate the feasibility of the use of a novel plant prot

miscellaneous food processing applications. In addition to the applications mentioned above, the proposed ClO2 monitor could also be us
bricated to implement the innovative optical immunoassays. These cells will be used to demonstrate the assay of a toxin, microcystin, and E

mics, the KSE technology provides propane at manufacturing costs substantially below market clearing prices for propane. When the deve
o scientists at the Institute of Materials Processing (IMP) Michigan Technological University (MTU) for industrial application testing. The oth
pecific example, industrial boilers account for nearly 35% of US industrial energy consumption. It is estimated that about 70 billion gallons o
on resistance, and high mechanical properties. A wholly new process is proposed to produce titanium powder that utilizes the basic proven

e aspects of a building product. For example, a GPSS may sell the function of a roof (structure, drainage, weather protection, aesthetic func
m-silicate insulative material designed to withstand continuous temperatures of up to 1000°C (1832°F). To evaluate the results, a pilot lo
on resistance, and high mechanical properties. A wholly new process is proposed to produce titanium powder that utilizes the basic proven
nnow microarrays for compound screening and use in environmental toxicology.
bricated to implement the innovative optical immunoassays. These cells will be used to demonstrate the assay of a toxin, microcystin, and E
e aspects of a building product. For example, a GPSS may sell the function of a roof (structure, drainage, weather protection, aesthetic func

ophores. Finally, BioTex will demonstrate the sensitivity and specificity of the novel sensing chemistry for field and laboratory use.
rch hopes to show that microarrays can provide information on the degree of environmental impact and the identity and effects of multiple

roducing ethanol at volumes and costs competitive with gasoline. This project seeks to demonstrate the feasibility of the use of a novel pla

icate insulative material designed to withstand continuous temperatures of up to 1000°C (1832°F). To evaluate the results, a pilot longitud
sifier-related technology, hardware, and service. Appropriate environmental protection will be a high priority.

n pesticides, and a toxin will be tested in water samples in the presence of various natural interferences. During the Phase II program, the S

o scientists at the Institute of Materials Processing (IMP) Michigan Technological University (MTU) for industrial application testing. The oth

nomics, the KSE technology provides propane at manufacturing costs substantially below market clearing prices for propane. When the dev
d miscellaneous food processing applications. In addition to the applications mentioned above, the proposed ClO2 monitor could also be us
pecific example, industrial boilers account for nearly 35% of US industrial energy consumption. It is estimated that about 70 billion gallons o
pid wireless fire detector system compatible with future and legacy aircraft. The wireless modality will send alerts to a receiver in the cockp
d classifying unknown states through their vibration and related sensor signatures, and for tracking progressions to failure. This phenomen
on security, the CM-Watchdog. The product we develop will have an aggressive goal seeking ability that uses the EPIC self checking architec
new class of materials for use as extruded optical fiber buffer. The new materials will have high strength, low cold creep, high fexibility and
nd the fact that it has a single supplier – Dupont. Linden Photonics proposes the use of a new class of high temperature, high strength ma

velocity vector, the number of camera pixels between the ICE and the boresighted munition centerline is a direct measurement of the veloc
is to assess the feasibility and robustness of single-frequency operation of two different OPSL cavity designs. The design that is identified a

trates a compelling need to develop and field in situ situational awareness sensors that can see through dust clouds and generate 3D terrai
meter. Areté Associates and Ultra USSI propose to develop an air-deployable GRSS employing a fuxgate vector magnetometer that will me
tion of sniper optics and neutralization of sniper threats in a compact robust package that will provide the autonomy currently absent in ex
pability come increased demand for time and attention to fy and monitor micro-UAV assets. Areté will provide Force Multiplication of mic
eld experimental data on the thermal behavior of disturbed soils. The resulting model serves as the centerpiece for the development and d
ors, and 3) Focal Plane Arrays of Detectors. The design concepts are then evaluated against: Reliability, Detector Sensitivity (detection range
eling and prediction, self-aware, self-healing systems can enhance current distributed system performance and allow for the deployment of
n (i.e. engine on or off). Future missile defense systems, such as the Airborne Laser (ABL) or next-generation Exoatmospheric Kill Vehicles (
to provide the desired balance between model fidelity and processing speed. The software tool will feature realistic models of battlefield o
 ETOC missions using: 1. a small, lightweight, low power sensor system employing an electronic gimbal concept for use on very small UAV C
nuously report its data. Our method is to develop a compact IOP sensor designed around the novel concept of a hyper-spectral modulation
onal benefit of robust performance during maneuvers. EMMFT will use the IMaQS-compensated magnetic field data to detect and continu
e sensitivity of the Kelvin wave pattern to a non-uniform shipping channel. The inverse model incorporating wave dynamics associating the

eloped by Soar Technologies, into Forterra Systems’ Online Interactive Virtual Environment (OLIVE). In addition to the exemplar simulations
es a mobile version of the SigningScience Dictionary with at least 1,300 scientific terms. Like the original dictionary, this mobile versiontarge
l size, high crystallinity and purity, applications as catalysts are being explored. Also, because of their crystallinity, the particles retain the pr

is routines that run in the same process space as the simulation. The open-source visualization application ParaView will be extended to co
absent from the process of visualizing the data, and are unable to work together to extract the most useful insights. This project will develo
climate (atmosphere and ocean) with biosphere models only crudely represent processes in the biosphere and their interaction with climat
as defined in the Phase I proposal, except for rise and fall times. The Phase II project will design, build, and fully test five analyzers able to
coating. The Phase I work plan consists of a demonstration of the measurement capabilities, an analysis of critical components and feasible
asily protected and manipulated in the vicinity of the test gas. We have identified several hollow core fiber types that appear to meet the
as well as to show the feasibility of integrating the sensor with different fatigue monitoring methods. The ultimate result will be a complet
oped under this program. The Matrix Laser Doppler Vibrometer (MXLDV) employs a 2D fiber-optic LDV array which enables high speed ima
on the analogy between the concepts of a TIL system and a laser resonator. Controlling the position and structure of the laser beam on the
e application of both schlieren techniques is restricted by the capabilities of fixed schlieren cut-off masks. Liquid crystal spatial light modula
ket plume applications. Because OH molecules survive at high temperatures for appreciable lifetimes, it is anticipated that the HTV techniq
red for inspection. This proposal provides a roadmap for development of a unique combination of optical diagnostics that enables characte
area on a target through a distributed simulated turbulent atmosphere. Using a model based on the analogy between the TIL system and a
t of new materials that allow significant increase in sensitivity to time at temperature; (2) an accurate optical sensor readout method that i
stic streak photography, and utilizes newly developed digital streak cameras and rugged diode-pumped solid-state lasers. The projectile tra
for focusing schlieren using the scanning method. In Phase 1, we developed an optical model of the system, tested the speed and linearity
ata processing and handling software. The core technology comprises a Matrix Laser Vibrometer (MLV) which enables high-speed capture
for these types of optical components have lagged the capability to manufacture them. The proposed work will build upon a successful Pha

tion regardless of whether the speech segment is a silence, a transient or a sustained vowel. We will also apply different scaling factors to d
l-time voice transformation system (RVTS). Firstly, we will develop various state-of-the-art algorithms, which we identified as candidate tec
d high-value scenarios and both lab and field experiments will be used to evaluate and improve our design.

lity to identify and understand the roles of different nodes, understand the semantic relationships between entities and automatically iden
information into an anticipatory model that exploits traffic trends to predict the likelihood of future locations of vehicles of interest. This ca
ata for testing and evaluation as we move toward an eventual deployment to the BMDS. We enter the proposal aligned with two prime co
track correlation, making it suitable for use in the operational BMDS. Both of these proposed approaches will build on the DAC team’s com
o NASA at a relatively small cost by combining existing open source tools. In Phase I, we built an interface, which we call Parca, between th
.g. high-density, passive sensors, electronic countermeasures, etc.). We propose to perform heterogeneous data fusion via a state-of-the-a
mponent reliability data already available and provides an organized and mathematically principled approach to combining that data. Our t
ecisive Analytics Corporation/MIT (DAC/MIT) team proposes a powerful and elegant method which combines the desired expressive powe
d algorithms. The guidance and strategies contained within defense plans are not expressed in a form that is directly useable by engageme
k. With this transformation, however, come the technical challenges associated with creating and maintaining globally consistent tactical p

or automation. While each service has maintenance execution capabilities on its implementation roadmap, an efficient systematic proces
nce the launch of the current war effort. For these reasons, ensuring optimal feet readiness by creating and adopting new maintenance, re
and evaluate the product, Advanced Fuel Research will use the open source software of the Concord Consortium. The platform will be built

f the baffle in terms of fish health, water quality parameters, and cleaning effectiveness. Objectives will be accomplished through a team c

for the development of a DNA-based diagnostic that will effectively and accurately identify red snapper.
ublic and private laboratories. This work also has potential to serve as the platform technology for developing DNA-based methods for othe
h requires sophisticated computer monitoring and control systems. This project proposal will continue to investigate the potential for using
We propose to develop and test a simple and efficient device that converts ammonia in water directly into nitrogen gas using patented nan

order to increase cognitive skills, and learn content related to science, the environment, and civic engagement.

nnel catfish production techniques. Traditional methods require production of hybrids during the peak of the natural catfish spawn as a lar
3) develop algorithms using statistical or artificial neural network (ANN) methods for rapid sonographic analysis. The proposed work builds
sy to install, easy to use, reliable sensor hardware to withstand the harsh grain facility environment. And software that accounts for dynam

o overcome the limitations of conventional Fe sources. These SBIR Phase I studies are designed to verify the oral availability of SFP using a v

ials that are designed to address particular patterns of errors discovered through the assessment. The online activities will be designed to b
ide key support for Phase II and subsequent commercialization.

(3) perform an extended usability evaluation ofthe device in a range of activities in vocational, public, and daily living scenarios; and (4) pre

In order to test and validate the usefulness of soil images and analysis techniques, we propose to use soil image based pore structure info
ystrating
fermenting the mixed sugars
the technology contained
on a farm. in the hemicellulose
The Applicant fraction
is collaborating of agriculture
with the University residues to produce biofuels,
of Missouri-Columbia biofuel precursors
in this research. and fuh
The University
reenhouse gases that cause global warming.

stock as well as cultured shrimp. This could lead to a more rapid response for controlling the infection by allowing intervention before the

ave also described a method of producing autogenous replicon particle (ARP) vaccines using clinical samples from infected pigs. In this stud

odorous p-cresol as the semi-volatile challenge compound, metalized FEP containers consistently resulted in an approximate 3 fold recover

teaching valid chemical principles. The purpose of this project is to produce an intelligent molecular modeling kit and software suite for adv
methods can lead to road damage or safety problems, including risk of gas or power line hits during reconstruction activities, thereby jeopa

or is designed as a fat surface emulatingthe surface of the ground thus promotingnatural saltation activity, producingzero turbulence,elimin
has significant value. Our first goal is to validate an algorithm to control the daily light integral and CO2 concentration in a greenhouse whe

rphology over time in a non-destructive manner. This innovation has opened new avenues of research for plant scientists interested in roo
S, were compared against measures provided by the PRCS. The NCRS and PSC jointly developed results were used to identify viable applica

lect real data, typical measurement errors will be observed, allowing the students to use standard data analysis techniques to report on the

m in which vector amplification is initiated by the geminivirus Rep protein under control of a regulated promoter. The virus-encoded Rep pr

ted is anticipated to be ADA-compliant.

d further optimize nutritional aspects of insect and nematode production, development of scaled up prototypes for mechanization, and ex

train to demonstrate resistance.

is an alternative material. The pads and sheets are expected to contain about 50 percent manure as the absorbent in a nonwoven fabric th
 is that hydrogen gas can be made from inexpensive organic materials that are renewable and sustainable using inexpensive hydrogen-prod

ow-power,
he high-resolution
cell, including vehicle
many proteins sensor based
important on existing
for interaction electromagnetic
with immune systemsensor
cells technology we havecells
including dendritic already
and deployed in theAdditionally
macrophages. parking ind
g-term goal of this project is to develop safe and effective BG vaccine for commercialization and marketing to the aquaculture community.

ood pH, resulting in protection against the stress. The current proposal will evaluate the effect of increased dEB on total in-transit losses un

o create a managed code breaking hot spot called a silo. These silos are designed to be internet based and use a web front-end to make it e
mercial software for facial recognition and Lockheed Martins WISDOMTM system. In Phase I, Aculight will modify its PerseusTM eyesafe fib
generator will be pulsed to produce the desired neutron-pulse time structure and a high peak yield. The present deuterium generator will b
indicated that the design will provide a system that can be deployed in water up to 4 km deep and detect all noncooperative vessels appro
electrical cable. The complexity and weight of these systems makes them difficult to carry over rough terrain or deploy during airborne res
curity cameras to search for the characteristic small spots that appear in images when a radiological source is nearby. Vidiation Radiation A
and tested in the field. The technical risks of this development will be presented to allow DHS to gauge the likelihood of success of the effor

availability of tool for the detection of rootkits that have been maliciously introduced onto Windows platforms. This is accomplished, not b
areas of a superior collection system design: 1) a non-contact surface excitation technology that dislodges particles and vapors from any sur

ization limitations and the relative ease of tampering of these systems impose a severe risk to the security of radioactive sources used toda
anizing wireless body area network sensor platform, as an antidote to this pernicious situation akin to the fog of war. This Small Business In
o distinguish them from routinely used radiopharmaceuticals as well as naturally radioactive materials. The goal of the proposed effort is to
eutrons while rejecting effectively background gamma rays. Rugged and low-power neutron detectors are highly desirable for large-scale de
of a particular isotope. This technique, however, has one significant drawback: In the presence of dense surrounding material such as lead
capacity and can be used as electron sources for e-beam applications including field emission and field ionization. Phase I will include a pro
Materials, components and device designs will be refined and optimized. The CNT ion source components will then be integrated into DMS
TC) and the University of Minnesota defined an innovative technology called Logical Network Boundary Controller (LNBC) that will cost-effe

pping vehicles in the safest possible manner. Our proposed Phase II effort is an extension of the successful Phase I project. We clearly show
encryption product. The work during this phase will involve comparing the performance of the proposed solution, using a single FPGA, ag
ally notify the required first responders will play a significant role in helping evacuate victims in a timely manner and therefore save lives. D
existing firewall. The SINBAD design will be modular and extensible thus able to leverage software inspection capabilities developed by thir
high quality botnet collections being used in Microsoft MSRT, Live OneCare and Window Defender, Endeavor proposes to develop a robust,
user in danger during deployment. ESA has developed a device that is a significant improvement over current technologies in that it is not a

998 MHz) and X-band (9303 MHz) linac designs for the IMAXS. In Phase I, the optimal design characteristics will be described, essential vari
oat with existing boron deposition techniques. Therefore, the Phase I project will combine the unique expertise at HY-Tech on efficient boro
al health status monitoring for the duration of their crisis involvement. Specifically, the core innovations of the proposed project include: 1)
n-contaminating and leaves no residue, a small vortex attractor transport system capable of sampling up to a foot away, and a long life reus
nt data reduction techniques are needed so that efficient data classification techniques can be applied to a low dimensional data. Our prop

ties, and are being designed and implemented using low-cost sensor nodes, the possibility of cyber security vulnerabilities and incidents in
ber Optics Systems, Corp., IFOS, proposes to meet the demands of this sensing challenge using fiber optic distributed temperature sensors

availability of tool for the detection of rootkits that have been maliciously introduced onto Windows platforms. This is accomplished, not b
n-tethered, electro-muscular disruption (EMD) projectile for a 40mm grenade launcher. A standard 12 gauge shotgun cartridge will be deve
materials. In spite of being highly sensitive, currently used explosives detectors are only as good as the samples they are presented with. Cu
phased averaging algorithm. The locations of these targets are then rapidly relayed to an FLIR which focuses on each potential target in tu
eness, legal and social acceptability of the Taser&reg; with the ease of use, practicality, and extended range of shotgun shells. Utility of the

al features are annotated with statistical measures or probabilities, and the results of various runs are combined statistically. Toward this en
gh development of sensor fabrication techniques and through the application of new drift-compensation algorithms. The technology build
-fux neutron detection in high gamma fields. The successful conclusion of this work will provide a compact prototype system that can be c
of addressing some of the existing problems including sensitivity and stability. Our approach focuses on the advanced nanoparticles and as

rator that would match the requirements of high rate individual photon counting and spectroscopy that would allow identification of SNM
with digital output. DRAG determines the peak value of dielectric losses in the monitored material, which is proportional to the amount of
more than 1 L of air. For a trace level of PPB, this will yield a few nanograms of trace explosives, approximately 3 orders of magnitude mor

dout light emitted by LED or intensity modulation of the test light passing through explosive vapors. Near-trace-level sensitivity is achieved
, executable system design and integration approach, including testing and support plans and simulation results. In Phase II, POC plans to d
Nuclear source gauges (such as beta and gamma) are used in industrial process monitoring and control, often to measure thickness or mass

bility, baseline stability, and long-term The final optimization of these materials will allow the development of a sensor system will allow th
time; high sensitivity with low false positive rates; and low cost. It is a valuable asset for DHS as well as the veterinary, environmental and h

e positioning deviates from its boundary limits. In Phase I we will demonstrate proof of concept with low level laboratory sources and build
nnovative
prototypeuser interface.
detectors. TheWe will create
neutron a threat
detection management
efficiency mechanism
of our best to evaluate
prototypes collected
will be tested events, provide
in collaboration withfor mitigation, and will deve
Battelle.

ndard which is easily and robustly implemented across various control systems making it reference for vendors and users and results in inc
nsportation, plant automation, and traffic control, there is increasing risk of tampering. In this effort, Toyon proposes to develop a wireless
onal 25,000 units. TransTech has developed a spectrographic impedance instrument which uses low energy electromagnetic signals to dete
e envisioned device will support existing and planned commercially available biometrics handheld scanners via IEEE 802.11 or Bluetooth wi
ck on a container enroute, before it arrives on US shores, and give exporting and importing companies more transparency of the conditions
ow power consumption, long battery life commercial requirements for tracking and monitoring of goods transported globally. The detecto
alities of current state-of-the-art with fexibility/reconfigurable, P2P communications, security, embedded intelligent software and low-cost
with existing personal protective equipment, can be used in all forms of structures, not cost prohibitive, and allows responders to competiti

ombine ERCo s technology with UTDs signal processing and optimize the results. The commercial applications are significant and represen
Both visible and UV fuorescent tagging agents are readily available. Which type is used will depend on whether or not it is desired that th
itate the use of anticoagulation for the rest of the patient's life. The trileafet polyurethane valve, originally developed in the design of the A

ore reliable in serial over parallel studies. New Mexico Resonance, the research institution of this proposal, has perfected the technique to m
rs endemic to the U.S. health care system, nonetheless a reduction from the present rates of incidence in long-term and homebound care i

emerging needs. To overcome these methodological limitations, we propose to increase the final amplified RNA yield by 1) improving the e
ight manual wheelchairs. The backrest will be designed with a battery of features that benefit the user including height selection, backrest
mining. The representation of chemical compounds as graphs captures the essential aspects of chemical structures in a natural way that ca
ying HRS and SSA micro data, which is essential to the continued willingness of respondents to participate in the study, but they severely lim
brication techniques will allow for the development of commercially efficient and low cost manufacturing processes. The proposed near te
it. Although the underlying causes leading to "dry" AMD are complex and involve a variety of hereditary and environmental factors, the fin
es, which are key risk factors of macular degeneration, a process that eventually leads to blindness. Importantly, however, there are curren
we propose to develop a compact diode driver and implantable single channel cochlear stimulator. Identification of the optimal fiber place
ers must bear to attain and use CMS administrative data in conjunction with popular federally-supported surveys/registries. To date, MedRI
ers must bear to attain and use CMS administrative data in conjunction with popular federally-funded surveys/registries. To date, MedRIC's
tions which are difficult and time consuming. Currently, there are no conjugation kits that are commercially available for scientific and biom
ere is a lack of technology for the fabrication of high quality carbohydrate microarrays for high-throughput analysis of glycomes because of

al. Those who do select more functional devices often find existing units offer disappointing or inadequate performance for play activities
al entail screening compounds from ATL's library and ongoing synthetic chemistry program on A2AR antagonists to identify two therapeuti
s reporting insulin independence, or substantial improvement in patients who suffered from type I diabetes. In addition, auto-islet transpla
nd in animals tests. Since C. perfringens epsilon -toxin forms a heptameric trans-membrane pore similar to the PA pore, we propose to scre
e-consuming, expensive and often require substantial technical expertise to administer and interpret. The Alertness and Memory Profiling
aboratory sleep studies to facilitate rapid, cost-effective diagnosis of OSA at home. ARES proved effective during the Phase I study in confirm
apies to prevent or treat symptomatic hypotension include: decreasing the ultrafiltration rate, reducing the amount of fuid removed during
ening analyzer will help reduce the blood analysis volume, reduce the time-to-result, and make the analyzer available at the point-of- deliv
ting for the developed wire- less polysomnograph sensors and the associated software package. FDA approval is required prior to the comm
tter manage their chronic conditions, they have inherent limitations. For most people home computers are stationary machines that are oc
phase II. The proposed pocket size EEG recorder will be small enough to be worn relatively unobtrusive during daily activities. This will allow
more severe illness that would likely require inpatient hospital care in a pediatric intensive care unit (PICU). However, intervention strategie
ntifying of regional changes in cutaneous temperature. Spinal unloading will be done using the LTX 3000(tm) Lumbar Rehabilitation System.
he recent commercial availability of low-cost high-precision miniature motion tracking sensors (accelerometers and gyroscopes) and stand
r topology. The connecting wires, which are secured to the body, may (1) restrict body movement, especially with children, and (2) add nois
etic anomalies render a magnetic compass useless for finding a directional bearing. However, these same invisible anomalies represent val
depth electrodes, and fine wire microelectrodes for multi-single-unit recording. The proposed UWB wireless EEG system will make possible
pecific but small subset of patients. There is a clear need for additional therapeutic options including other novel targeted therapies. The 88
tation of the targets relative to the tissue section. The immediate goals are to develop a panel of 7 assays (comprising antigen-coated mem
blood has lead us to the identification of appropriate target peptides. We have developed a panel of 21 short peptides which were formatte

ring processes are scaled up in later stage clinical trials, or for marketing, it becomes less and less acceptable. As scale increases, increasin

ed phase I study of AdV4k + prod rug gene therapy in recurrent malignant gliomas demonstrated a safe dose range for AdV-tk in brain tum
s quantification of these components of breath would be a powerful method to identify and differentiate lung diseases and their severity.
se are in the process of being phased out by the EPA and FDA due to their high ozone depletion potential (ODP). Newer MDI devices are no
treatment takes the form of a so-called artemisinin combination therapy (ACT) in which an artemisinin derivative, most commonly arteme
oject is to analyze this data to generate new understanding of underlying biological mechanisms which can lead directly to a marketable pa
(CSR), most animal studies focus on acute and total sleep deprivation. Technical difficulties in creating CSR animal models have long hinder
patial memory. Since different behavioral assays always require different specialized techniques and apparatuses, researchers rarely conduc
nless they integrate appropriately into the damaged tissue via complex mechanisms that involve proliferation, differentiation, integration an
h metal implants would clearly benefit society. We propose to develop a generalizable peptide coating that will allow a clinician to choose f
ografts, xenografts, and synthetic materials. Allograft and xenograft are favored because they possess some osteoinductive elements especi
enous delivery of osteoinductive agents such as the bone morphogenic proteins (BMP's) (Sykaras and Opperman 2003). In contrast, there
tion of miniaturized gyroscope, accelerometer, piezoelectric and novel electro-mechanical sensor devices and be able to wirelessly transmit
here is strong scientific support and rationale for a role of heparan sulfate-decorated Perlecan in angiogenesis or neovascularization. The he
rlecan, are proposed, along with innovative studies investigating their role as therapeutics in bone healing. Site-directed mutagenesis to th
m the core of the problem is how technology is being used. Our main objective is to deal with the science apathy challenge by creating eng
a portable personal monitor and a data collection infrastructure that will facilitate a high resolution reliable monitoring for individuals over
voices. With InvTool, individuals such as those with ALS who are at risk of losing the ability to speak can record their own speech for conve

ve developed and patented the use of 'neutral' opioid antagonists that block the unwanted actions of opioid drugs, but have significantly lo
pen source software infrastructure that enables interoperability in heterogeneous clinical and translational research, and to develop targete
ssue shapes and sizes encountered in the human body, the ability to reshape the expander by the surgeon with scissors and scalpels is desi
ded because it is difficult to differentiate between viral and bacterial infections based on clinical signs or radiology of the presenting patien
cations. The objective of this Application is therefore to develop an integrated, sample-to-answer PCR array for infuenza diagnostics in clin
ughput into highly complex culture and assays systems such as MEAs will facilitate their wider application discovery, but will require sophis
hemiluminescence, fuorescence resonance energy transfer (FRET) and time resolved fuorescence. Current optical detection systems for th
s underlie the complex molecular events that are indicative of TBI. The high- speed and high-immediacy assessment of these proteomic ch
goal, several novel readouts based on new designs of charge-coupled devices have been developed. However, current X-ray-to- light conve
ld otherwise escape detection by conventional radiography. In biomedical and pharmaceutical research, neutrons are used in macromolec
t cancer using near-infrared (NIR) based diffused optical tomography (DOT) technique. Image contrast will be improved by using contrast ag
elry and clothing. There are regulatory limits to the content of lead used in consumer products. However, many are voluntary and most app
ricate and could fill the availability gap at lower cost. But because LSO is optically anisotropic, it cannot be made fully transparent by conve
r's disease, head trauma, and stroke. PET technology is also playing a prominent and an increasingly visible role in modern cancer research
s these limitations, we propose to develop a high speed, high sensitivity, and large area detector for x-ray microCT. The detector will be bas
sis as well as prognosis. SPECT is more commonly used in localizing coronary artery disease and as many as 90% of myocardial perfusion stu
ow sensitivity. The overall goal of the proposed effort is to combine the best features of PET and MR modalities for small animal studies int
te detectors. Current two-dimensional detectors for neutrons do not provide adequate area coverage, spatial resolution, sensitivity, and ge
optotic protein in striatal cells and acts by preventing caspase-3 activity." It contains the fact that the gene id 6532 (in the Entrez Gene data

hod that utilizes inexpensive instrumentation. Significantly, the method presents a general approach for enhancement and detection of agg
n titering methods have serious limitations. Agglutination reactions are generally detected visually, that is, in these tests, the technician su
awal-induced negative affect. However, of the three drugs currently approved by the FDA for the treatment of excessive alcohol consumptio
ther and entrapment. A layer of the antibacterial peptide prepared in this way should be safe, functional, and long-lasting. This Phase II SBI
motionally, the procedure frequently causes internal scarring, which may obscure the results of future mammograms. With approximately
e, resulting in potentially powerful therapeutic index. The pathlengths of a-particles are short, on the order of 55-80 fm (~4-6 cell diamete
esearch is to proceed to later stage clinical trials and approved drug products. Also, additional amounts of the isotopes are required to supp
ls into its optical platform for multiplex detection. Our long-term vision is to develop a system comprising an instrument and application-sp
VE- PRO). These protein libraries can be expressed inexpensively in a single cell-free translation reaction using a Bead Sorted Library of In V
or detecting these mutations and genotyping mutant viruses. However sequencing is both expensive and most importantly does not easily
-Plus) or low compliance due to rigorous preparative requirements (colonoscopy). The principal objective of this project is to develop a cos
es in children with NF1. There is a critical need for a cost-effective test to screen for mutations in the NF1 gene. However, a significant prob
umors that escape detection. The pathology of cancer is accompanied by numerous changes in the genome and transcriptome. Thus, ther
wild-type transcripts will provide substantial benefits for diagnostic and prognostic testing and clinical management of these diseases. Acc

subjects ranked
c methods) and to sustain native-like receptor structure, function, and stability. In preliminary data for the human kappa opioid receptor (K
puter, which both collects and stores data from the sensors and generates voice messages over speakers on the hospital foor. The research
stitute studies that include a determination of the optimal dosing time (i.e. a range of time points from 30 min before meals to 60 min afte
eous regeneration of the liver and preclude the need for transplantation; in the most severe cases, they will serve as a "hepatic bridge" un
 nfammatory responses evoked by adenoviral proteins, inherent instability of proteins in solution, their limited tissue half-life and exorbitan
ptosis to minimize lung injury during preservation. Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleiotropic growt
patocyte growth factor (SF/HGF) has been shown to be over-expressed or mutated in a variety of solid tumors including gliomas. Binding o
32%) or $4,731 per person annually, indicating that costs are spread over the long disease duration. Currently, there is no known cure and t
giving birth. While women are two to three times more likely to get RA than men, men tend to be more severely affected when afflicted. In
tment of brain and SCI. Administration of an HGF/SF-like compound holds promise as a new approach to the clinical management of SCI. H
0,000 resulting in the addition of 60,000 children with new brain injuries annually. The incidence of stroke in neonatal children (
ms that enable the visualization of green fuorescent protein (GFP)- and red fuorescent protein (RFP)- expressing tumors and bacteria (Natu
therapies. The recent development of an HCV clone that is infectious in cell culture (termed HCVcc) can directly address these shortcomin
nging from about 8 to 100 amino acids can be produced for a few dollars per gram, in contrast to chemical synthetic methods for which cos
d distinguish AMD patients from normal old adults in = 20 minutes. This aim was easily achieved. A range of early to late AMD patients wa
orter channel AQP3, into phosphatidylglycerol (PG). PG appears to be involved in at least two important functions: inhibition of keratinocyt
n D3-3-bromoacetate (1,25(OH)2D3-3-BE), an analog of vitamin D designed to have increased antiproliferative effects while reducing system
several other conditions, such as congestive heart failure. Several in-home assessment devices have been proposed over the years, but no
r necrosis factor-a (TNFa) that are of central importance in eye disease. We hypothesized that sphingosine-1-phosphate (S1P) produced by
re, the use of islets from a different species, such as pigs, and induction of tolerance without the chronic use of immunosuppressive drugs w
t may prevent against recurrences. However, their therapeutic potential remains to be realized partially due to the complex nature of intera
r vaccine for cervical cancer which overcomes these problems. The vaccine, designated ApoVax104-HPV, is based on the use of a proprieta
tself is not toxic to cells in vitro or after injection intranasally or intrathoracically into mice. The external surface of APMS can be modified f
pitate material. Most commercial microscopes used to analyze protein crystallization setups provide crystal edge contrast only, which is no
plication will be tested using a competency pre and posttest and in a high fidelity patient simulator. An iterative design process will be emp
y. Preliminary studies found that when a graphic display of arterial blood gas information was used, the visual ABG display was more effecti
dict non-responsiveness to noxious stimuli in a wide variety of patients. The results were positive. The models adequately predicted clinica
to improve existing prosthetic valves; or to establish criteria for MPHV implantation (e.g. orientation) under which valve performance will b
ase I grant support, we will develop a process for high-yield purification of APT102. We will then utilize clinically relevant embolic model to
ssfully engineered a clot-targeting human apyrase, APT202, which exhibits significantly higher enzymatic activity and platelet inhibition tha
fication and remote activity monitoring tools that deliver real-time species identification of fying mosquitoes. Our labor-saving automated
ata, along with a variety of physiological endpoints, will be the basis for a relational database. We will analyze the data and decipher the pa
annually. Approximately 30% of the symptomatic lung cancer patients will present with an airway obstruction requiring local tumor contro
, recall, or even read the consent form. To ensure understanding of informed consent, didactic alternatives to the current informed proces

ut directly accessing samples, constant sample concentration changes due to evaporation, excessive time required to aliquot samples, and
to optimize data access and make it amenable to sophisticated logical queries, computational analyses, and data mining. However, existin
to treat chronic P. aeruginosa lung infections in CF patients. The major hypothesis to be tested is whether alginate specific mAbs can be us
ct injection into the brain is not effective, because only a small part of the brain is treated with a trans-cranial delivery system. Conversely, v
ore, and that will be more fexible and easier to use than existing systems. Its design will also permit substantially lower capital and running
ctal cancer screening. In addition, the use of CFM could reduce or, under some circumstances, eliminate the use of deep sedation for colon
nesis plays a role. Retinal neovascularization involves the development of sprouts from retinal vessels, which usually penetrates the inner l

. The ability to biopsy the mouse based on an imaging study and to perform repeat biopsies in the same region of the mouse would enable
ransmission measurements will be made through the thin skin on the back of the hand of the sleeping person. The patient will initiate the
ults in a distinct protein "fingerprint" structure that can be identified, distinguished from other agents and their conjugates, and quantified.
ing key clinical issues for using MAPC as an off-the-shelf allogeneic product. After receiving feedback from the FDA following a Type B pre-
d laboratory animals for various types of research involving painful procedures are rodents. A survey of current literature indicates that bup

that are not present in the target genome but contains a specific sequence in the target genome. This is done by creating two site-specific p
 requires that the tester change the transducer arrangement several times during pure tone testing. In manual testing, this requirement ca
Vancomycin and Teicoplanin, which for years represented the "agents of last resort" for treatment of antibiotics-resistant infections, are no
o the inner ear of the guinea pig. In previous work, supported in part through SBIR Phase 1 and 2 funding, we have developed the FDA app
at periodic subcutaneous dosing can reduce or eliminate many of these problems. The potency and the long elimination half life of these d
oated pure drug particles. High drug loading and sustained release kinetics have been achieved with several other drugs and this technolog
pulmonary fibrosis. Hence there is an urgent need to develop therapeutic agents that delay or reverse pulmonary fibrosis. Accumulating ev
d for 2) Evaluating new therapies targeted and reducing plaque burden in large multi-site clinical trials. To test this hypothesis, a novel 123 I
cells in pancreatic islets. While ground-breaking studies have recently demonstrated proof of concept for C-DTBZ imaging of BCM, the app
, numerous clinical complications as well as a limited amount of expendable nerve segments, have necessitated a search for an alternative
ervous system. Peripheral neuropathy is a major side toxic effect of exposure to chemotherapy agents that are used for the treatment of ca
- Construction of rBCG that constitutively expresses a tissue adherence factor - The objective of this aim is to produce an rBCG that constitu
e is no blood- based diagnostic tool to aid clinicians in the diagnosis of mild and moderate TBI. However, such a rapid, reliable, and sensitive
and reliability) of the proposed new approach for assessing the functional impact of pain (FIP) in pain clinic patients with chronic or subacu
n) and an additional 25-50% exhibiting mild to moderate neurodevelopmental disabilities (e.g., school failure) [59, 95]. This SBIR Phase I gra
eory (IRT) and computerized adaptive testing (CAT) are the key technologies that will enable more accurate and efficient administration of p

r sterility assurance. Critical to the application is that sterilization processes are essential to the healthcare industry and are required to

to faster components, and limitations on the rate at which bio-sequence data can be streamed to the comparison logic. This proposal seeks
ntions. We will also revise the follow-up program for the Windows version (Follow-up College Drinker's Program, FCDCU) and integrate follo
as: To support individuals who have chosen to abstain, or are considering abstinence from any type of addictive behaviors (substances or
atified sample of middle and high school students (N=1600) and clinical sample of adolescents with a diagnosed behavioral health problem
ortability advantages. The proposed online training program will substantially aid in the vital training of both community clinicians and clin
RCT). PCT-A is a cognitive-behavioral, evidence-based treatment for panic disorder in adolescence and a developmental modification of the
d GPCR ligands. However, development of inhibitors to RGS proteins has been hampered by the lack of robust assay methods for high throu
his Phase I proposal is to develop a novel microfuidics device - called the Microfuidic Chemotaxis High Throughput System fFCXHTS (Fig. 1
annels for co-culture of mammalian cells in adjacent compartments in a three-dimensional format. The unique liquid fow properties at th
d human factors for the generation of beta cell/islets. The phase I goals are: 1) to translate our well-defined murine pancreatic progenitor c
t among all cancers in men, and it is the second leading cause of death resulting in 30,350 deaths in the U.S. in men in the U.S. in 2005. The

an result in greater strength increases at a lower acute metabolic cost and a lower rate of perceived exertion than traditional SC-LC training
mans makes them a useful surrogate for testing new medical devices such as stents. Pig and human cytochrome P450 enzymes are so homo

the laboratory scale, is not readily scalable for industrial application. A small number of enzyme activities that are capable of performing c
day after injection of the melanoma cells and the electric field strength is proportional to both the size and growth rate of the melanoma. W
he accuracy and precision of many procedures can be considerably improved. In addition, performing the procedure while the patient is in
to collaborate, but do not because they lack a convenient means to do so. Our mission is to improve clinically-oriented basic life science re
nificant tumor regressions in only 10% to 20% of patients. Sensitivity to EGFR inhibitors is largely dependent on the presence of somatic m
A technology for sale to researchers. One of the key aspects we propose to evaluate in the feasibility of commercially producing of all of the
entration factor as function of fiber geometry, device configuration and vacuum levels for protein solutions, using BSA or mixtures of BSA a
man health and more than 70 scientific publications and presentations demonstrate how it can be applied in a wide range of scientific inve
result in an expansion of the pneumothorax and death. A portable handheld pneumothorax detector that is inexpensive, accurate, and no
ffects of ischemic damage following resuscitation by optimizing the anti-infammatory properties of the hypertonic saline (HS) (7.5%) resusc
promotes hemostasis in cases of severe bleeding that would otherwise lead to exsanguination. This approach is based on the physical and
riability, until now datasets exhibiting spatio-temporal variability have been largely unmanageable, and researchers have been forced to sim
disparities), and visualization of changes in disparity through time. This product will allow the investigation of geographic and ethnic variati
 sets of matrices of nearest neighbor relationships that refect the changing space-time geometry of the residential addresses of cases and
nse mechanism relating to IOP that can lead to more effective development and titration of glaucoma medications or other timely therape
allel analyses of individual DNA molecules in a high- throughput manner thus providing statistically relevant data in a timely fashion. As
search will result in the development of new methods to produce purified polyclonal antibodies. These methods will allow the rapid produ
atients with objective findings suggestive of the disease. Prompt diagnosis is important because early treatment of Lyme disease limits or p
rvoir hosts and from the ticks that feed on them, the enzootic cycle would be broken, and the incidence of Lyme disease would decrease. T
osis and treatment of kidney disease has been extensively reviewed and published as a K/DOQI clinical practice guideline by the National K
ls were successfully prepared that combined neutron activation analysis, electron microscopy, fuorescent imaging and magnetic resonanc
trast agent that can simplify data acquistion and image interpretation of MRA procedures could propel wider utilization of this diagnostic to
death receptor 3). TL1A induces both apoptosis and infammatory responses in vivo and in vitro. Tissue localization of TL1A has been repor
eceptor, DcR3, has been demonstrated for its survival effects in animal lethality induced by apoptosis. Moreover, the level of DcR3 was sign
at 830nm and 1300nm wavelengths, respectively, however the slower image acquisition rate and lower signal-to-noise ratio of the older te
tiate development of an HIV viral load diagnostic suited for resource-limited settings, in response to SBIR-AT-NIAID, which called for the adv
b) DNAs and (B) the ability to efficiently and specifically insert these large DNAs into bacterial chromosomes. The specific aims of the propo
cence quenched probes are highly suitable for genomic, biochemical, and immunoassays. Because the fuorescent signal is generated only
ary to separately filter the two signal bands. This allows the phase relations in action (single cell) and field (population) potentials to be cap
these into output speech using sophisticated algorithms. It requires, however, a large amount of recordings and a high degree of consisten
sequences show that certain bacterial groups are present in the mucosal fora of IBD patients. These findings have led us to hypothesize th

demonstrated efficacy to reach the African American community. BioTechnical Communications, Inc. (BTC), the applicant organization, is p
owing needs; a) shorter treatment times, b) elimination or at least reduction of the use of excipients c) delivery of fine respirable aerosols w
terize a microbial identification platform using very rapid MALDI-TOF mass spectrometry of modified ribosomal RNA fragments. By generati
ulin pump control algorithm may substantially increase both the safety and effectiveness of insulin therapy in diabetics. BioTex, Inc. has de
totic cells. This bi-functional caspase substrate allows studying heterogeneity of cell population during apoptosis, early detection of apopto
iences, the Port-a-Patch system from Nanion Biosciences, or the PatchXpress from Molecular Devices Corp., is around 50%. In other words
cting and enhancing target objects even when they fill only a small portion of the device's field of view, without the user having to point th
an lead to implant loosening, accelerated implant wear, and eventual revision surgery. The Overall Aim of this project is to develop a compl
on-gamma proteins that can be administered less frequently, but with greater potency, than existing interferon-gamma products. During Ph
growth factor (VEGF) appears to play a critical role in the differentiation of endothelial cells and the development of the vascular system in
n (with focus and astigmatism compensated before MEMS-DM correction). Because mirror deformation is doubled in the wavefront by ref
most worry for PE. Although many diseases elevate the D-dimer, few diseases besides PE obstruct blood fow to large volumes of alveoli. Th
iofilm growth, encrustation, and subsequent infection are the most common mode of failure. Coatings that could render these devices inhe
r commensal and pathogenic bacteria to re-colonize in the non-sterile environment of the oral cavity. Cariogenic bacteria usually re-domina

g-term objective is to solve key and fundamental problems with proteomic technologies, as described by the world's leading scientists. The
ead to reliable measurements of exposures, which can be correlated with variable susceptibility to metal toxicity in the human population.
n-metal metabolites with no a priori knowledge of which proteins are involved. Therefore, antibodies to specific proteins or specific protein
on, oxidative stress and aberrant protein aggregation. We are focusing our efforts on testing the latter hypothesis because pathology studie
enerative diseases. Here we propose to develop and implement a high-throughput rational target-based screen for compounds that increa

oncentration of particles in saliva) as a powerful marker of human hydration. Cantimer, Inc. has been developing a microelectromechanical

ns on the basis of key similarities to the mouse cardiac cells defined by stem cell antigen-1 (Sca-1). Phase I STTR support enabled the Appli
ition, doxorubicin is limited by dose- dependent and cumulative toxicities, the most serious of these being irreversible cardiomyopathy and
clinical monitor like pulse oximeters. The main challenge for clinical application of cerebral oximeters has been to demonstrate the effecti
eveloped to aid program dissemination; the training tools available to practitioners and institutions are not adequate for widespread clinica
omodulator. This was observed through marked reduction of A?/?-amyloid plaques and associated astrocytosis. In concert with this down-r
developed by Dr. Parenteau (Amaranth Bio, Inc.) and Dr. Rosenberg (McGill University) for obtaining endocrine progenitor cells. This propo
vel strategic approach to develop new methodologies to improve the quality (integrity and function) of human lung cells (hLC) and tissues b
uring ablative freezing processes - a regime that couples traditional cryosurgery with adjuvant (e.g. 5-FU, cisplatin) treatments. This approa
roach has recently led to the initiation of a physician sponsored IND for the treatment of advanced stage prostate cancer. This Phase I proje
otein acetylation levels in cancer by elucidating their mechanisms of action. It will also identify new acetylation sites that could become tar

ed on one or a few phosphorylation sites; curation and organization of this information was relatively simple. Using tandem mass spectrom
sting with pharmaceutical companies on drug compounds that passed animal studies yet still caused liver injuries during clinical trials. If C
echnology for High Throughput Screening (HTS) of biologically active peptides in a disease-relevant cell model has not been developed so f
hroughput (HT) RNAi screening is technically challenging and significant limitations in the technology exist. To address these issues, and to
creens in mammalian cells. Despite these successes, high-throughput (HT) RNAi screening is technically challenging and significant limitatio
XRT-induced gastrointestinal (GI) injury. We postulate that the repletion of the myeloid/megakaryocyte progenitor pools will protect agains
100 mL columns, which will be validated using fu virus propagated in 5-10 L cell culture medium. The column-purified virus will be evalua
asma, is part of the standard care of HIV-infected individuals. Two critical decisions in HIV/AIDS patient care are primarily based on HIV vira
ces is estimated to exceed $113M in 2007 (D&MD Publications, 2005). Current cardiac safety assays using either animal cells or hetero
Verification System, or "PVS"). Currently, verification is performed manually by way of visual inspection. The pharmacist opens the prescripti
een applied to benchtop pharmaceutical QA solutions, offering enhanced spectral resolution with unrivaled sensitivity. Traditional spectrom
ction to these elements is difficult due to the large number and orientation, and dicing of such fine structures often results in missing elem
ave adequate performance, and require acoustic mirrors or are not directed in a way that provides the most clinical significance. In Phase I,
f this validated drug scaffold, a simple, rapid, robust method to 'glycorandomize' macrolides may launch the discovery of a wide range of an
novel cardiac neoglycoside leads found in a cancer drug discovery program at the University of Wisconsin. The necessary IP to pursue this
seeks to apply this approach to the preservation and procurement of viable islets for transplantation. The primary objective of this proposa
of darkfield and brightfield illumination, and spectral analysis. Software will be developed to acquire and analyze multiple images with diff
nsequently, various governmental bodies (e.g., EPA, FDA, and ICCVAM) and proactive corporations have explicitly expressed a desire to have
rapy of ocular NV. Therefore, searching for and developing new drugs to block retinal NV via targeting VEGF signaling or VEGFR have initiate
hat are leading the discovery and development of drug products to treat severe eye disease. The company is developing the first eyedrop-b
drugs to block retinal vascular leakage via targeting VEGF or the VEGF receptor (VEGFR) have become a major incentive and research effort
orm the antiquated microagglutination test upon which diagnosis now depends, it is well recognized that human leptospirosis is an under-
ensitivity and specificity. Here, a completely new gene expression technology is proposed that, while obtaining high sensitivity and reliabilit
sized malonyl-CoA is used for fatty acid synthesis. We propose to screen a small- molecule library to find novel inhibitors of ACC2 as lead co
t will be developed as the basis for an innovative arsenic removal technology for drinking water with higher capacity, good selectivity, and e
ant women at high risk of premature delivery. Studies in animals have lead to the discovery of several cervix-derived candidate biomarkers
ontext and expectations. TEACH is innovative in that it utilizes several lines of research in technologies and methods in the rapidly evolving
tibodies and other immunologically relevant molecules. Subsequent culture of the captured cells under different conditions can be used to
latform and a clinical research program to facilitate comprehensive differential phenotyping of patient samples on the basis of parallel dete
ive, and consume large numbers of T cells to test limited numbers of targets. Sample size is an extremely important consideration in T1D a

nto a single step. In addition to saving time during hookup, the electrode will eliminate the handling of "messy" substances typically used i
g, and presenting multiple symptoms related to the diagnosis of Parkinson's disease (PD). No biological markers currently exist for antemor
nown as multiple drug resistance (MDR) during treatment of several CNS disorders, such as drug refractory epilepsy or intractable brain tum
hat psychoeducational interventions are effective in reducing caregiver stress, depression, and burden; the dynamic nature of the Internet
 ather & Baker, 2003). To address this lack of training we developed and evaluated the first of six web-based one- hour modules on the asse
ontinuation of analog synthesis efforts and the pharmacological evaluation of CDD 0304 derivatives are proposed in this application, with a
myloid deposition. Recent studies have implicated cerebral microvascular Aa deposition in promoting neuroinfammation and dementia in p
tic strategy for a difficult gastrointestinal disease in which adequate treatment strategies do not currently exist. Specific Aim 1: Using a C. ro
nately, this approach does nothing to reduce neurodegeneration of dopaminergic neurons such that the severity of PD increases. Any new
4 allele is associated with increased risk of sepsis following elective surgical procedures and following cardiopulmonary bypass. Cognosci Inc
egy for developing a new therapy for MS to address this critically unmet medical need. Our interest in developing apolipoprotein E-based r
ory/neuroprotective ApoE-mimetic peptides that significantly ameliorated disease severity, promoted functional recovery, decreased histo
eal adhesive for bone repair should promote rather than retard osteoblastic activity (Drobnic 2006), and should resorb in the timeframe of
faces. What surgeons require is a sprayable "glue" that can fully adhere planar faps of tissue without requiring direct contact with the tissu
small lipophilic molecules that penetrate the intact stratum corneum and activate the dendritic cells (DCs) in normal mouse skin. They enab
nguage training systems focus on production skills and do not provide adequate perception training. The proposed project will develop a sy

processes. In addition to work on IPA-water, two other pharmaceutical solvents were successfully evaluated. Leaching studies have shown t

apidly absorbed from the intestine without metabolism and appears to exert its hypoglycemic activity by inhibiting glucose uptake from th

ntation, and norming of a practical assessment protocol and instrument that can quickly provide a standardized outcome assessment of pa
principal investigator for NASA in the past (published in the NASA Tech Brief Journal, 2004). Utilizing this combination, mass spectra of exh
e prevalence figures for clinical pain disorders are not available, as different surveys have yielded estimates varying from 7% (Bowsher, Rigg
el will be further refined, incorporated into an electrostatics modeling software package and used to study biologically significant systems re
se wounds, including the use of tissue glues or grafting, can be even more problematic. Phase I studies were conducted to measure the bio
moglobin levels can be measured noninvasively in a small initial study. The conjunctiva is illuminated with a low power broadband white ligh
tis of the mandible. Surgical excision of hard and soft tissues of the head and neck or high impact trauma can lead to major tissue deficits. R

mputerized adaptive testing (CAT) instrument based on an existing Late-Life Function & Disability Instrument (LL-FDI); (2) compare the accur
in three dimensions, which will allow movement into and out of a bathtub, onto and off the foor, as well as onto and off a bed under whic
rding to investors, bankers, industry analysts and entrepreneurs, comparison tools are still at an embryonic stage. They suffer from limited s
al stepping pattern thereby exercising the lower extremity musculature, providing a cardiorespiratory exercise opportunity, and providing th

ur months of age, are particularly susceptible to methemoglobinemia. Treatment with inhaled nitric oxide for patients with respiratory failu

cells for high expression of a secreted product (e.g., antibody) is a particular challenge because the secreted product does not remain assoc

rated generation of mechanically functional cartilage within a brief period of in vitro culture and (ii) resurfacing of an entire joint instead of
s, but will score all agents which positively modulate any aspect of cytotoxic recognition and effector mechanisms. The identification of add
ne. Furthermore, in collaboration with Dr. JR Falck (University of Texas, Southwestern), we have begun testing synthetic EET mimetics and h
m of action of these cells remains unclear. Further, it has been shown that cells with vascular potential derived from other tissue, such as b
ard solution NMR methods. This is often because they are too large and therefore tumble too slowly for optimal NMR performance. In addi
ractions, organization, and abstract thinking, which makes tasks like interviewing for a job, completing college applications, and searching fo
nts: 1) A facilitator's guide, which will feature talking points, exercises, and role plays, as well as tips for interacting with groups and individ
evy, & Metry, 2004). TTM is rarely screened for in clinical or research settings and often goes unrecognized due to the secretive nature of th
e tend to be worse for low-income and minority children residing in urban areas (Griffin, Cicchetti, & Leaf, 1993; Knitzer, 1996). Unless we c

escent substance abuse that can be replicated, evaluated, disseminated, and easily integrated into existing youth treatment programs (Denn
 or latent variable models have been studied and applied. In the analysis, the major interest is to study the impact of specific cause pathway

complicated life long treatments impacts a patient's health and burdens the medical system. Adolescents are particularly vulnerable to poo
video to address an important and overlooked public health problem-the negative impact of BPD on family members-is an innovative conce
her alcohol prevention tools for adolescents, and provides teachers with classroom implementation techniques, engaging and developmen
soluble dipeptide pro-drug, BACPTDP in 100 g quantities - sufficient for preclinical studies. 2. Verify the anticancer profile in xenograft stud

valuate the usability, cultural acceptability and workplace benefit of both English and Spanish versions of the module. Pilot test the revised
f China 2000 Census data at the township level (including geographic location data) is now available to researchers outside of China. This va
ent system exists that allows a surgeon to easily incorporate MIS into their surgical routine. The development of a unified MIS instrument sy
are less well known. In many jurisdictions, social hosts can also be held liable for actions of their intoxicated guests, and need the same kno
e secondary prevention (early detection, patient-specific oral treatment, and referral) of eating disorders as they are often the first health p
nderstand how to optimize structural features in the bRCQ molecules to yield the best possible, orally available drug against malaria. This w
ll make these data available to a broad audience in the form of reports, charts, maps, spreadsheets, and GIS output. A subset of the HRS da
The project is a competing continuation application that proposes to conduct pre-clinical and clinical studies on the DRW HBsAg rapid test
oteomics (DCP), which can identify the differences in protein composition between two biological samples. This technology also simultaneo
es are isolated. A novel subtraction step removes those affinity reagents against proteins held in common between the two samples, leavin
ith a composite adherence measure through the study. The overall system will be initially tested using data from patient use-case scenario
MA index that is calculated based on performing signal processing of voice acoustics and will correlate to standard clinical depression rating
of a sensitive 2-galactosidase (2-gal) complementation approach utilizing two genetically engineered fragments of E. coli 2-gal termed Enzy
ally engineered fragments of E. coli a-gal. The larger fragment, Enzyme Acceptor (EA), contains a deletion near the amino terminus, while th
th DGI's ongoing SBIR project to deliver Factor VIII and IX genes in appropriate animal model systems. Thus, this project has high-impact po
wo-component SB system consists of a transposon (inverted repeats fanking a therapeutic gene of interest) and a transposase that catalyz

the continuous monitoring of personal protected noise exposure; this metric has previously been unavailable to the hearing conservationis
(ivermectin, albendazole, diethylcarbamazine) are effective at killing larvae (microfilariae), the adult reservoir of parasites (macrofilariae) s
microscopes. Each microscope in the array includes a variable-optical-power, liquid-lens element. The liquid-lens elements are controlled e
acid. While some current tools incorporate advanced methods to design for sensitivity, designing for specificity typically depends on BLAS
tissue-equivalent gel that develops a stable color in response to and in proportion to radiation dose delivered locally. In Phase I we have de
ons in mouse and rat models of Alzheimer's disease, and mouse models of cardiac and liver disease. The S/N gains for many single- resona
complex, helical membrane proteins. Moreover, the major NMR probe manufacturers have not offered significant advances in the needed
ng sample loss risks. Phase II considerations will involve developing interface/adaptation components to fully integrate devices with instrum
w direct x-ray converter material, polycrystalline mercuric iodide, which is a high-Z large-band-gap compound semiconductor with outstand
are optically coupled to a scintillator which is operated in a current-integrating mode where the signals generated from the x-rays are integ

ajor breakthrough is that the MMPF now allows measurement of instantaneous BP and BFV phase relationships over longer time period fro
tor and to screen for antibiotic activity from environmental DNA libraries, in both low and high copy, transferred to native and genetically m
medical products used for biomedicine, biomedical analysis, diagnostics, and treatments. However, one significant drawback of diamond m
formulas can then be used to accurately measure energy expenditure in infants, which has important implications in the determination of
n earlier and with more accuracy. The long-term goal is to incorporate this assay into a simple, inexpensive, point-of-care device to aid in di

mings both in the development of the sensors and in their applications. In this Phase I STTR, we will develop innovative mycotoxin sensors b
disease. This bacterium, along with the other major cohabitants of the "red complex" (Treponema denticola and Tannerella forsythensis), is
e high cost associated with SLPI refects high demand combined with limited supply, given that production of the non-glycosylated cationic
olytes alone. The chaperonin/osmolyte folding system is synergistic and folds proteins to high yields, at high concentrations, and at physiol
principles such as detailed description and multiple levels of practice with feedback will be embedded into each segment of the programs.
 the second innovation will be investigated and the performance of a complete system projected. In Phase II, a preliminary laboratory appa
molecules with substantial current fow. Current patch clamp methods used to study this current fow are limited in two key areas to maxim
ated and life science-related experiments designed to stimulate science interest and self-directed student research. In this Phase II project,
mical roughening, are inexpensive to make, operate in vapor phase under a wide humidity range and in solution. As the sensors are tuned
tted first in each well with MRAs to the proteins of interest, and then exposed to the analyte solution containing one or more of these prot

he main target market for this package will be either the major manufacturers of MRI scanners or an established company that creates and
y system for use in a school environment with the aid of advice from focus groups, identified the potential privacy/legal hurdles, and assess
Metagen applies patented, cultivation-independent methods to obtain natural products from the "metagenome," or collective genome, of
zes a novel physical model of the radial pulse to determine BP via pulse analysis. The compact design of the device makes patient mobility a
on, and by resistance in acceptance at the practitioner level. Problems include the widespread perception of need for adaptation, and persi
s too inclusive for local planning and decision-making. Despite increasing policy expectations that prevention will be driven by local data-ba
s into an AAC device and the VG tool translates each icon into synthesizer parameter strings that control the acoustic characteristics of the
re-excision have not been adopted because they required a pathologist in the O.R., take too long during surgery, and only examine less tha
here are major limitations and risks leading to their lack of universal acceptance as leader in the field. Embolic agents are difficult and dang
achieved via coils that induce arterial stasis within the dome leading to clotting and later fibrosis with ultimately obliteration. The major lim
w national laboratories. A suitably bright, compact, low cost light source is the enabling innovation needed to realize a commercial biologica

itical tool for use in resolving uncertainties about the relationships between exposure and human health impacts. In the proposed pro
is technology also having a role in the international arsenic contamination picture, particularly in countries such as Bangladesh, where ove

the same "virtual reality" visual perception of three dimensionality as "VR goggles," but without the need to wear headset, and viewable o
ytic disease of the newborn (HDN), a severe and potentially fatal syndrome, the prevention of which relies on a diminishing supply of hum

th to change fow by 20-45%, with associated small changes in mouth pressure. From these changes, resistance is calculated. APD is simple
bryonic stem (rbES) cell lines available. Pronuclear microinjection, however, is of low efficiency, results in random integration, and cannot pr
n of occluding arterial thrombi in multiple models of injury-mediated arterial thrombus formation. The extent of PK activation regulates the
quest for funding is to enable extension of the technology from murine hybridomas to two distinctive diversity sources: recombinant antib
hat can maximize anti-tumor effects while minimizing the toxicities associated with treatment. One such modality, immunogene therapy, h
nism of action based upon its anti-infammatory effects and natural ability to stimulate tear fow. A natural component of tears, lacritin not
e sequences (EpiTagTMs) found within every protein. By utilizing a sandwich assay format with the EpiTagTM technology, Epitome has deve
ematic). This proposal is aimed at development of a rapid CD4+ count assay that addresses these concerns. The assay will combine current
51 genome. In the next phase of the research program, building on our own experiences and our collaborations, we seek to develop the op
cessary to develop a less immunogenic FVIII that will provide hemophiliacs with the benefits of prophylactic Factor VIII therapy without th
roposed is to develop and commercialize the rapid chiral separation and characterization instrument: electrospray ionization - chiral ion mo
first century. This proposal describes the current and proposed activities of a multi-disciplinary team of physical and medical scientists who
ggant" or a metabolite of the taggant on the breath of an individual shortly after ingestion of a medication containing it. MAMS will include
wer imaging and diagnostic modalities are required to monitor atherosclerotic plaque buildup in the arteries. Novel and proprietary ga
develop cell lines stably expressing kinase-specific molecular markers for quantifying catalytic activity of specific kinases of interest in cell-b
transplantation for use in the reconstruction of soft tissue defects and contour irregularities associated with craniofacial surgery. The prop

d of colon, breast, lung, ovarian, and prostate cancer patients compared to normal subjects. Recent data have emerged which directly impa
n microfermentation screening. Microfermentations make possible the economical screening of large numbers of mutants in order find im
efore the information gained from this study could be applicable to a broad range of pharmaceutical compounds including other antibiotics
I of this project, a UCB-specific probe able to detect physiologic and pathophysiologic levels of free UCB (UCBf) in neonatal plasma was pro
first two years is approximately $ 30,000. The cost of DFU to the healthcare system is over one billion dollars per year in the United States.
with the effectiveness of small duplexes. Consistent with the basic research/business mission/plan of the Foundation for Applied Molecular
rch and consumer products (sunscreens, cosmetics, paint) is also creating an array of ultrafine materials with largely unknown health effect

for five common patient-care activities, including assessing and managing pain. The goal is to use the system with at least 5 nurses and 25
which will be realized by combining a unique implementation of time-resolved fuorescence spectroscopy with Monte-Carlo code that mode
se II period. The specific aims of the grant are: 1) Development of fuorous-based peptide microarrays. A new fuorous linker (2-chlorotrityl
rol interface, with disposable 96-well microfuidic chips, that enables cells to each be controlled, monitored and manipulated individually. T
ned to help schools respond appropriately and to students whose school success and healthy development are threatened. This Phase II ap
non- compliant, refractory and/or suffer from adverse effects. Current surgical implants are passive devices unable to detect or respond to
wild type and the mutated drug resistant HIV-1 strains. It would be also difficult for the virus to develop resistance against cellular functions
ging time by a factor of 4 or more without a serious compromise of image quality is very important for patient comfort and picture fidelity.
2001 and a 170% increase from that prescribed in 1999. Further, Frost & Sullivan report that that the market for androgens is growing at a 2
ile low dopamine has been implicated in the pathophysiology of depression, particularly the feature of anhedonia, there is currently no anti
 the impact of the adversarial activities; knowledge of what assets have been compromised or are being threatened; the ability to anticipa
we propose to conduct extensive numerical experimentation and development to minimize risk. The AMM theory will be deployed to a wel
ired to evaluate the potential for active acoustic sensors which were also explored in Phase I. Finally, we will integrate the RKPM meshless
put metrics such as electrical impedance profile, TVR, and directivity. WAI, in partnership with Materils systems Inc, will initially develop a T
ut and over twice the stroke of conventional piezoceramic actuators, with faster response times and is an ideal active material for PDE fuel i
2) a fielded first-article template generating processing unit that can be built and delivered within the budget and schedule limitations of an
ametrizing them for use as loading functions in the detonation room as well as adjacent rooms. We propose to use the MAZ computationa
cept or exploit the transmissions. The proposed waveform class also employs turbocodes as its forward error correction mechanism. The c
anagement databases in operational environments. This design can also be adapted to re-key legacy radio systems. During Phase II, Weste
ars are a deliverable for Phase III testing and commercialization. A new rolling/sliding contact fatigue rig for micro-pitting is proposed for m
etermine bioluminescence detection risk, and 3) a simple, graphical user interface to display real-time threat risk. In this Phase I proposal, w

picuous arrangement. Williams-Pyro has alleviated initial programmatic technical risk and proven Accu-MiSTS’ Phase I technical merit thro
s of individual networks to choose routers and routing protocols. We propose a framework BGP-MANET that is able to make router and rou
nificantly mitigate the identified problems, if appropriately adapted and incorporated into the platform avionics and weapon integration de
e measurement of TBC’s) with a similar wireless temperature sensor being developed by Wireless Sensor Technologies. That temperature
eering of a 4x4 array of horns, will be generated.

eakage behavior post infection. An effective solution needs to be scoped correctly to address the information leakage problem. It needs t

oping ultra-low-power software defined radios, and integrating the elements of the sensing, communication, and networking subsystems in
equipment; operate seamlessly with legacy equipment; and provide a modular plug-and-play architecture. Williams-Pyro’s Intelligent Energ
facilities. This network of portable, distributed, intrusion detection sensors discriminates between acoustic sources of interest (speech, veh

nimum spur-free dynamic range (SFDR) performance of 80 dB in a 1 MHz bandwidth. The final design or designs will be documented in a so
ed to demonstrate the effectiveness of this innovative solution.
bjectives of the Phase I program will be to show a complete propulsion system design that masses 5 kg and has a useful propellant mass fra
nsitive for real-world tactical handling. If this fuel is desensitized for safety, it no longer works as a monopropellant because the catalysts no
witched-reluctance machines such as those for aircraft applications. The second is relevant for a wider class of machines. Both can be app
tform services and devices, and CF. The SDR Diagnostic Tool characterizes waveform performance data and standards compliance and prov
me of the final development work planned for the vehicle is directly relevant to Air Force ORS goals and systems. Second, additional work t
real world view; and in AR: combining virtual and real images. It supports both video and optical see-through at dynamically variable blen
hat is developed with a model-based approach, (b) representations of diverse, yet coordinated, behaviors affecting security policies and ce
and application levels. The result is a unified model based design and analysis environment that reduces the cost and risk associated with
on and analyses required to support certification through open and fexible means. This approach enables diverse stakeholders to effective
so that critical information can be transmitted in near real time across the existing data link (which currently handles 30 frames/sec video).
will be analyzed in detail. The proposed tool will be developed on software platforms including MATLAB, STK, and QualNet. Feasibility of the
e toolset provides a high-fidelity network simulation model, which can be integrated with the Navy’s existing converged IP network model.
a portable passive CCD imager integrated with an eye-safe lidar rangefinder to acquire plume backscatter data to support both daytime con
e propose to develop a highly rugged dropsonde technology that is mechanically-compatible with the thousands of ALE-47 electronic count
edium fidelity representation, so that different levels of performance can be established, based on input from the Government sponsors. I
ovements will also result in an ability to operate at higher voltages which, when combined with lightweight aluminum hardware, would resu
nts of the test system will closely match the existing GPS infrastructure already in place to support the warfighter, with a natural transition p
ven in the total absence of GPS. This solution also features innovative security and low probability of detection (LPD) techniques. Because
neering and environmental services we currently offer to our clients, thereby, mitigating potential risks associated with bringing a new prod

e of the cavity. The compacted particles are then used in this state or are sintered at a temperature to add strength to the particle while m

ductive aids to perform at reasonable capacities. Yardney Technical Products proposes to develop a high voltage (5V) olivine-type phosphat

er various environmental conditions. These batteries will provide a lightweight high energy storage device for military applications.
the feasibility of detection of subtle variations of ocean surface roughness by identifying signatures of natural phenomena, such as tsunam
ies in oxygen cathodes and powers sources will be adopted in the design of the lithium-air batteries. Advantages of the proposed lithium-a

o of the device by at least two orders with a bandwidth over 3.0 THz, and consequently, extend the standoff detection distance from ~10 m
• Uses a closed system filled with an incompressible fuid where volume displacement is transmitted at speed of sound, enabling fast sacc
arious FP angle and AoA under gust excitations. Next, using CEFM we will fully investigate various F-16/HT cases, including strained/unstra
linearities for morphing wings subject to structural uncertainty. The gridless-boundary-condition-Cartesian grid (GBCC3D) method will be f
point in the two-step and two-point procedure, (3) the two-step procedure will get large error from the truck vibration and pavement unev
essure explosive TNT. In addition, sensitivity limits will be determined for a range of other customer-identified compounds. The Phase I op

The work proposed here will lead to cells that are a drop-in replacement for cells currently used in the BB-2590 and will lower cost, provid
he geometry of the Eddy Brake is coaxial; hence it is magnetically self centering, which ensures a clean translation during deceleration. Ultim
The impact that this technology, when fully developed, on processing, yield rates, and operability of HgCdTe FPA’s cannot be overstated. In
r’s hands featuring augmented aerogel with impressive thermal performance. Using a new infiltration process, Aspen will transform conve

er consumption, and will determine its efficacy within a system integration recovery (SIR) environment developed by L3, our DEC teammate
II project, we will develop further the PLADAR system for potential integration into Naval platforms such as the Firescout, a Vertical-Takeoff
monstrate the device’s ability to automatically and accurately control the removal of topcoat and/or primer layers while preserving underly
n exhaust. The final packaged device will incorporate features that allow the theater to be used safely, effectively, and easily. It will be suita

HgCdTe/ZnCdTe diodes. Amethyst will team with BAE in Phase II to develop hydrogen passivation technology to improve operability and yie

al stimulation, accounts for most of the sensation of motion present in a real setting. Our oculo-vestibular recoupled fight simulator will th
materials, and developing a design concept that integrates these material into the cooling sub-system.
main active in their civilian and military lives. The Infoscitex team is developing a multilayered socket that takes advantage of a novel braide
g point depressant additive (
e development of a new controlled release technology that will repel insects from lightweight camoufage structural netting such as the UL
sing a novel approach to meeting the requirements called for in the solicitation. At the conclusion of Phase II, we will have demonstrated o
ors that are air-transportable, shelf-stable, and low cost. The Phase I project will focus on the design, fabrication, and evaluation of a labor
rPc. To address the need for ante mortem diagnosis of the prion disease the IST and CSU team will attempt detection of the pg quantities o
current technologies integrated into a novel detection and labeling system that is robust and covert.
dress this proposal. In conjunction with our university research partner, we are proposing a novel and innovative approach to meeting the
attention to bone-coupled noise. Infoscitex is a leading innovative engineering firm and proposes a device that attenuates bone-coupled v
ion duties. (e) A seat cushion with optimized configuration and material provides improved seating comfort. The seat is stowable, and its w
silicate-elastomer hybrid bond (SEHB) will exhibit the following advantages over DC93-500: Enhanced resistance to radiation, optical transm
tion. The resulting technology will allow an analyst to view a satellite image for any place in the world, automatically find and align the ma
directions. This in turn provides a better estimate of the moving target velocity vector for tracking and imaging purposes. The subaperture
es to be sized solely by current requirements and not g-loading. This will lead to thinner gauge wires and further synergistic weight savings.
tion effort has been started in Phase I and will continue during the Phase II and Phase III of the program.
minate in the validation of the armor construction, and the airfow evaluation of a full sized grille. Manufacturing endeavors are scheduled t
e Phase I tradeoff effort will enable the Army to select a preferred approach, from among the candidate options presented, for detailed de

ven beyond the level currently achieved by the most-successful group. Phase I work focused on software tools intended to aid in data anal
nt that is based on the input of, and interaction between, past and recent mission information and incident reports, field intelligence, and
alculated by our system is presented to the soldier as a quantity, as well as delivered to an on-person computing system for further proces
ineering techniques. An application process scalable to meet foreseeable demands from the DoD will be developed. The Phase II program
to cancel the unwanted effects of a centrifuge trainer on the vestibular system. Gravity-Induced Loss of Consciousness (G-LOC) is a seriou
uildup, and eliminates high-cycle fatigue more efficiently than currently available coatings. In Phase I, we prepared uniquely structured coa
m will be conducted to increase the voltage breakdown of the DE and actuation of the EAP MERs fabricated in Phase I. The Option Tasks wi
Phase II complete sensor packages will be fabricated by Infoscitex and tested in collaboration with Dr. Jennie Gallimore. In addition, a com
methodology is informed by both anthropology and political science, the former providing a local level perspective and the latter providing a
he battery to provide a stable interface with both the anode and cathode to control passivation phenomena at the electrodes, promote go
ost instantaneously and have minimal impact on solar cell efficiency. In the Phase II effort, it is envisioned that different generations of op
tors such as NVG weight, distribution of weight, and system center of gravity are important to aircrew fatigue, neck strain, injury due to egr
tivity material and can be optimized for low pressure drop and low power consumption in pumping liquid through the cold plate. The prop
ermal performance. The goal is to enable a two- to three-fold increase in power density in wide bandgap semiconductors and to manufact
herapeutic actions of the most effective PC-NSAID we have identified, Indomethacin-PC (vs. unmodified indomethacin) in rodent models of

ss allowing for easy scalability to manufacturing scale. In design of the fake, consideration will be taken toward not only selecting the right
OFC. This project proposes a parametric investigation of the integration of the application of advanced SOFC and thermoelectric technolog
address dissemination issues needed to further enhance the Figure of Merit. NanoDynamics will deliver several samples to the Army for ch

ke advantage of their superior EO properties as well as ease in fabrication for high density device integration. In the proposed project, relati
not been fully demonstrated on an aircraft engine. This SBIR will integrate the hardware, software, and data from mature, robust, commer
or about a minute to extract nucleic acids. The easy-to-use approach can be automated. The plasma lysates produced have been demonstr
n and decision support algorithms, physics modeling and inlet fow control will require significant computational resources. The U.S. Air For
ady applied magnetic field produce a large axial body force on the plasmoid. The thrust is produced by the action of external fields and the
band gap, and nonlinear photonic crystal device structures. Early in Phase I, potential candidate devices will be down-selected based on c
h resolution roughly comparable to the GEN IV NVGs, while providing visible, NIR, SWIR, and LWIR sensitivity for 24/7 vision enhancement c
bility to confidently confirm that certain WMDs were or were not present in an engaged threat complex will be key to alleviating concerns
will also be considered to support the configuration and analysis of the new equipment. This may include changes to the real-time operati
e fy and is supported by industry standards based [hardware agnostic software development fow and] programming model using ANSI-C
uality Assurance – IPQA – will be implemented to sense and control vital aspects of the welding process not possible with current approach

ction scenarios between new candidate standoff engagement lethality enhancing concepts and attacking missiles. Phase I will develop Sta
properties of the POSS feed stock present an unusual opportunity to the electronics industry; a conformal coating that also actively mitigat
, and the primary objective of Phase II is to ruggedize the backpack for manufacture and military deployment.
s of abstraction and may not share the same geometry. This proposal focuses on the development of an environment for multidisciplinary
ent and system-level models of electric machinery and power electronic systems operated in fault conditions. Validation of the PHM conce
y and through an experimental setup (rotating machine) in order to (a) test the alternative of using only in-service failure time data to evalu

eveloping a pedestrian detection algorithm that performs competitively with other published pedestrian detection algorithms; exploring m
small volume, and are purely mechanical and contain no damping elements to ensure consistent operation and very long shelf life of over 2
ophex; develop and build, in co-operation with the ARDEC staff, sensor-mounting contraptions for a candidate vehicle; conduct demonstrati
d by multi-radio/multi-channel mobile devices, and investigating appropriate routing policies and metrics. During Phase II, we will also eva
of these items, in good condition, is necessary to save human life or limb or to alleviate human suffering. Thus, an RFID system with the abi
R applications. Magnolia plans to demonstrate high performance carbon nanostructure based detectors and arrays for infrared imaging ap

ons but also in a thermal/vacuum chamber replicating Mars pressure and extreme temperatures. Alliance now proposes to adapt the desig
(2) a manipulator system consisting of a robotic arm and end effectors; (3) a hybrid engine system consisting of a biomass combustion cham

ate the systems ability to provide commercial value.

associated hardware has been designed. For Phase II, it is recommended to partially populate the systems feedhorns, amplifiers and detect
are addressed. The project involves extensive dynamics and finite element modeling of the proposed concepts, as well as their various com

upply CO2 to vector surveillance light traps. The gas generator produces CO2 from a chemical reaction between two non-hazardous mater

ct proved the feasibility and methods required for extensive (pond) culture. Our Phase II project will capitalize on those discoveries and dev

r optic transmission distance for quantum communication networks and quantum-key-distribution (QKD) systems.
stem for operations from a small vessel in an ocean environment.
eing analyzed. As part of this project, we propose to develop a prototype system to demonstrate the feasibility of our approach.
e SLM will be designed for use in the 3 - 5 um spectral range, and it will eliminate the intra-spectral diffraction associated with the DMD de

c explanation and debugging services in Pellet, an OWL DL reasoner, to increase the usability and comprehension of integrity constraints fo

upports indefinite endurance and lifelong monitoring of animals. The emphasis on small size and low cost continues to enable tracing of m

an AC measurement system it is possible to drive the polynucleotide through the protein pore at a relatively slow rate while observing the c

ations on the substrates will be investigated. Finally, a prototype gas sensor device will be constructed using the SiC nanowires grown in thi
evelop the proposed CO2 sensor will be to develop a unique sensing electrode that is specific to CO2. Complete sensor cells will be fabrica
e and were successfully demonstrated during Phase I. We now propose to construct the CLASP commercial prototype, and to install it at a
e to select appropriate model inputs in order to attain meaningful received level metrics. GUI-based software tools will be provided to eas

d genetic diversity of offspring.

quartz, gallium phosphate and langasite for operation up to 250°C and then further to 600°C; (4) design and assemble a breadboard instrum
Prof. Fiorenzo Omenetto of Tufts University propose development of mid-infrared supercontinuum sources based on newly available optica
using the capabilities of a number of open-source products. Moreover, the system will provide crucial visualization tools aimed at helping u
characteristics are demonstrated, we will then be in a position to integrate the MgO-MTJ sensors with oscillating MEMS fux concentrators

ol system and create a versatile graphic user interface. The Phase I feasibility study also uncovered the potential to add more features tot t
be designed and tested to evaluate its potential. We will analyze the system costs compared with existing methods. Results will provide th
meter which will confirm the design and prepare for fabrication of a deliverable unit in Phase II.
d to be implemented in the Phase II effort. In addition, the need for DNA extraction from fish tissue as part of an integrated microdevice w
ore narrow linewidths and better filter response. The proposed advances in VIPA design depend critically on core technologies unique to P
bilities of the algorithm, using Numerical Weather Prediction (NWP) to provide 3-6 hour forecasts of lightning threat, and incorporating pol
he CCR receiver module that is designed specifically for installation in the HIRad system. A compact-SFMR system will also be developed in
et-based radar digital receiver and processor system that provides compatibility between the NOAA and other radar systems and AAMPS.
mate Change Drought Decision Support System (C2D2S2) that will enable water managers at various operational- and time-scales to rapidly
ildren, the elderly, and the physically handicapped. Our approach targets the types of residential fires that are difficult to detect using conv
st containment operation by human and remotely operated vehicles alike. Techshot¿s experience developing specimen enclosures for ha
are at the same time ten times more sensitive than state of the art sensors. The proposed domain engineered thin film platform would ena
itional difference in sensitive nuclear materials. The innovative spectrometer requires only electrical power to operate, is completely autom

conditions are becoming unsafe. Use of an electronic sensor to monitor CO2 would offer a substantial improvement in diver safety.

The digester is modular and can be assembled by a small crew utilizing farm equipment. The digester is a moveable asset on the farm, repla
eld and laboratory use.

uring the Phase II program, the SERS database will be extended to include additional pesticides, toxic industrial chemicals, toxins and bacte

ffects of multiple contaminants in complex mixtures. In Phase I, three reference chemicals (diazinon, chlorphyifos, and copper), whose toxic
y of the use of a novel plant protein, HED2, to improve the performance of enzymes in the deconstruction of cellulosic biomass. Preliminar

d ClO2 monitor could also be used with chlorine dioxide generators to accurately control concentration of generated ClO2.
say of a toxin, microcystin, and E. coli bacterial cells. The success of the proposed work will result in the capability to conduct water monito

ces for propane. When the development program is completed, the Phase II technology can he utilized today, with current prices, to produ
strial application testing. The other portion of the tines will be stored for future testing by industrial partners.
ed that about 70 billion gallons of water per year are available in the combustion fue gas generated from these boilers. Our TMC technolog
der that utilizes the basic proven Kroll-type chemistry but is performed in situ, which eliminates the need for external sources of Mg and T

eather protection, aesthetic functions) instead of the roof materials. The roof would be owned by the firm offering the GPSS, and the firm
To evaluate the results, a pilot longitudinal comparative study will be performed, with the single- and composite-wall units operated side-b
der that utilizes the basic proven Kroll-type chemistry but is performed in situ, which eliminates the need for external sources of Mg and T
say of a toxin, microcystin, and E. coli bacterial cells. The success of the proposed work will result in the capability to conduct water monito
eather protection, aesthetic functions) instead of the roof materials. The roof would be owned by the firm offering the GPSS, and the firm

eld and laboratory use.

e identity and effects of multiple contaminants in complex mixtures. In Phase I, three reference chemicals (diazinon, chlorphyifos, and cop

asibility of the use of a novel plant protein, HED2, to improve the performance of enzymes in the deconstruction of cellulosic biomass. Pre

uate the results, a pilot longitudinal comparative study will be performed, with the single- and composite-wall units operated side-by-side

uring the Phase II program, the SERS database will be extended to include additional pesticides, toxic industrial chemicals, toxins and bacte

strial application testing. The other portion of the tines will be stored for future testing by industrial partners.

rices for propane. When the development program is completed, the Phase II technology can he utilized today, with current prices, to prod
ed ClO2 monitor could also be used with chlorine dioxide generators to accurately control concentration of generated ClO2.
ed that about 70 billion gallons of water per year are available in the combustion fue gas generated from these boilers. Our TMC technolog
d alerts to a receiver in the cockpit. The connector mounted format would wireless communications and provide additional fexibility for cre
ssions to failure. This phenomenological approach has been successfully applied and tested on a workbench including power supply, motor
es the EPIC self checking architecture. The CM-Watchdog will extend use of the “Business Rule Engine”, from control and diagnostics to tam
w cold creep, high fexibility and kink resistant. Fibers using the new buffer can be used in both ribbon and cable constructions. The fibers
h temperature, high strength materials for use as extruded wire harness insulation, with the following properties: no thermal degradation

direct measurement of the velocity vector angle. The Phase I program simulates the imaging sensor, develops image processing algorithm
ns. The design that is identified as superior through this Phase 1 effort will be subsequently developed in Phase 2, with the end goal of deliv

st clouds and generate 3D terrain and obstacle maps of the landing zone in near real-time to provide active visual feedback to pilots during
ector magnetometer that will meet or exceed the desired sensitivity of 10 pT per root-Hz over the MAD signal band. Surface motion noise
autonomy currently absent in existing approaches. Areté’s a counter-sniper high-speed autonomous optical system (CHAOS) being propose
ovide Force Multiplication of micro-UAV assets by developing an autonomous sensing and navigation system for micro-UAVs based on the i
piece for the development and demonstration of an innovative and rigorous tactical decision aid to direct the optimal thermal detection of
ector Sensitivity (detection range), Weight, Cost, Size, FOR Coverage Rate, Compatibility with Proportional Navigation Guidance Algorithms
and allow for the deployment of systems in situations never before possible with current fault-tolerant techniques.
on Exoatmospheric Kill Vehicles (EKV), will rely on very long range ladar sensors to detect and track targets and discriminate targets from de
e realistic models of battlefield obscurants and clutter, such as fog, rain, smoke, and foliage. It will provide the capability to conduct trade s
cept for use on very small UAV Class I platforms and 2. a miniature gimbaled imaging system for use on small UAV Class II platforms. The m
t of a hyper-spectral modulation transfer radiometer. This instrument will measure the modulation transfer function (MTF) through a volum
c field data to detect and continually improve localization on the target throughout any maneuvers, exploiting electric dipole signatures in a
g wave dynamics associating the interaction of waves with the channel will be accomplished during Phase II and implemented in vetted alg

tion to the exemplar simulations, Vcom3D will provide a set of tools for adding and editing characters, behaviors, and culturally significant o
ctionary, this mobile versiontargets students in the middle grades.
allinity, the particles retain the properties (e.g., magnetism) of the bulk material which can be useful for applications as diverse as medical i

ParaView will be extended to configure co-processing algorithms/parameters and analyze data extracts. ParaView will provide the capabili
l insights. This project will develop a parallel visualization system to enable effective remote collaborations for complex data analysis in larg
and their interaction with climate. To achieve a better representation of the relevant temporal scales in climate projections, the models mu
d fully test five analyzers able to produce continuous, high accuracy field measurements of ambient levels of atmospheric gases, at very hig
critical components and feasible operating envelope, and a detailed Phase II design and development strategy.
r types that appear to meet the necessary criteria and these will be evaluated as a part of the solution.
ultimate result will be a complete prognosis solution for structural health monitoring. If the basic feasibility of this prognostic paradigm can
y which enables high speed image capture of any arbitrary surface vibration distribution including steady state (modal), random or transien
ucture of the laser beam on the target at the image plane of the system enables essential reduction in the beacon formation time. During
Liquid crystal spatial light modulators afford greater fexibility, as the correct cut-off mask can be programmed and updated electronically. S
anticipated that the HTV technique will work in even the highest temperature rocket plumes. The proposed diagnostic will provide measure
diagnostics that enables characterizing a surface figure and quality in near real time with two different, robust methods while monitoring th
gy between the TIL system and a laser resonator, positioning of the laser beam on the target is performed at the image plane of a receiving
cal sensor readout method that is insensitive to alignment errors and easy to operate; and (3) a data inversion method for reconstruction o
id-state lasers. The projectile tracking software that we will deliver has successfully been deployed at other test ranges. In Phase I, we dem
m, tested the speed and linearity of Galvo motors, and built a breadboard system, which we used to capture an image of moving objects. In
ich enables high-speed capture of spatial vibration patterns including random or transient processes. This feature of the MLV is unparallele
k will build upon a successful Phase I project that demonstrated the feasibility of a novel technique for full aperture precision metrology of

pply different scaling factors to different parts of speech segments. During the optional six months, we will focus on creating multiple voice
h we identified as candidate technologies for Phase II. The VTP is a software application where users can perform the entire process of voic

n entities and automatically identify important clusters of entities within a dynamic social network. Our advanced algorithms developed un
ns of vehicles of interest. This capability can be utilized in concert with sensor resource management (SRM) algorithms to improve the abi
posal aligned with two prime contractors making it extremely likely that this work will be commercialized and deployed in the near-term, w
will build on the DAC team’s computational techniques for performing inference in large-scale network models. These technologies, combi
which we call Parca, between the Paramesh computational libraries, developed at NASA GSFC to support AMR computations in the area c
s data fusion via a state-of-the-art fusion algorithm which will naturally and easily accommodate new and diverse sensor types as well as u
ch to combining that data. Our team consists of staff who have already contributed to the development and testing of candidate compone
nes the desired expressive power of conventional logic with a sound and consistent treatment of uncertainty, resulting in an automated rea
is directly useable by engagement management algorithms. The DAC team proposes to close the gap between planning and execution thro
ning globally consistent tactical pictures across the distributed ad-hoc sensor networks. To meet this challenge, the DECISIVE ANALYTICS Co

p, an efficient systematic process of data capture and programmatic data input has not been adequately addressed. This project proposes
d adopting new maintenance, repair and overhaul (MRO) strategies has become primary initiatives of DoD Air Logistic Centers (ALCs) acros
 rtium. The platform will be built using one of the most advance TELE systems, SAIL, which is currently under development. The product wi

accomplished through a team comprised of AEB Engineering, WSU researchers, and Andgar Corporation, an industrial fabricator.

ng DNA-based methods for other food markets."

vestigate the potential for using Polyhydroxyalkanotes (PHAs), a biodegradable biopolymer produced from sugar fermentation, as an altern
nitrogen gas using patented nanotechnology procedures, and a process called photoelectrocatalytic oxidation (PECO). Several variables ne

he natural catfish spawn as a larger percentage of females have mature oocytes at this time. Because our hatchery space, labor, and water
alysis. The proposed work builds on preliminary evidence that levels of varroa mite infestation in hives and exposures to air-borne toxicants
oftware that accounts for dynamic factors such as grain type, grain quantity, storage structure architecture; to effectively alert the user abou

e oral availability of SFP using a validated in vitro CaCo-2 cell culture method that is a current scientific standard. The research also probes t

ne activities will be designed to be used by children either at home with parents or in the classroom under the supervision of the teacher. A

daily living scenarios; and (4) prepare fortransition into commercialization. The portable handheld system significantly enhances the user¿s

image based pore structure information in three different modeling approaches: pedotransfer functions, physical models and fractal mode
ofuels, biofuel precursors
in this research. and fuel
The University hasadditives. During
prior research in Phase I, a and
this field, genetic
has improvement program
the farm equipment will beinexecuted
needed onIIenteric
the Phase study. microbes to identi

allowing intervention before the population becomes lethargic and anorexic and less susceptible to treatment. Such a low cost test would a

es from infected pigs. In this study, the feasibility of producing ARP vaccines in a timely matter will be studied and compared to the produc

in an approximate 3 fold recovery increase relative to Tedlar equivalents. This Phase II project proposes capitalizing on two key features of

ing kit and software suite for advanced placement chemistry classes for real-time communication between the hand-held physical model a
truction activities, thereby jeopardizing continuation of the desired trends toward universal below ground facilities. The BIN may be deplo

producingzero turbulence,eliminatingreverse direction particle activity from bouncingoff obstructingsensor surfaces and does not allow th
ncentration in a greenhouse where the algorithm will control CO2 concentration and the daily light integral target in the most effective and

plant scientists interested in root systems.

e used to identify viable application domains for the system in forestry research, identify shortcomings in materials and approach that if co

alysis techniques to report on their own unique data, just as if the experiment had been performed using actual laboratory equipment. The

moter. The virus-encoded Rep protein initiates rolling circle replication and, through interactions with host proteins, induces DNA replicatio

types for mechanization, and expanded pest control efficacy testing.

sorbent in a nonwoven fabric that may be composed of natural or synthetic fibers. The first prototypes have already been produced and ar
using inexpensive hydrogen-producing bacteria. Despite its clean and green nature when utilized in fuel cells and other devices, most hydro

seady
and deployed in theAdditionally,
macrophages. parking industry. With
since BG additional
retain modifications
these structures, theybydoannot
experienced
require thetechnical
additionteam, this small,
of adjuvant lightweight
to induce sensorrespo
an immune will
to the aquaculture community.

dEB on total in-transit losses under commercial conditions in approximately 90 truckloads of finisher swine. We predict that increasing dEB

use a web front-end to make it easy for law enforcement agents in the field to submit the headers from encrypted files. The back-end of th
modify its PerseusTM eyesafe fiber laser product to meet DHS needs and LM will design the system changes to interface with the Aculight
esent deuterium generator will be redesigned to support the safe use of tritium. The proposed system will be designed to be low cost, and
all noncooperative vessels approaching US shores while operating autonomously for at least a year. Among the many commercial applicatio
ain or deploy during airborne rescue. The opportunity lies in creating a light weight and powerful system which the rescue spreader can be
e is nearby. Vidiation Radiation Analytics Detection System (V-RADS") software detects these image artifacts. The software s data capture a
likelihood of success of the effort.

rms. This is accomplished, not by searching for the particular &lsquo;signatures&rsquo; known to be carried by this type of malware, but r
particles and vapors from any surface to make them available for collection, and 2) a superior collection/concentration system that rapidly s

of radioactive sources used today in the homeland and in other countries. Our approach, if shown to be practical and effective, will result
og of war. This Small Business Innovation Research Phase I project will prove the feasibility of creating AIDnet, a cost-effective, rapidly depl
goal of the proposed effort is to investigate promising new scintillators for homeland security applications.
highly desirable for large-scale deployment. This research develops a neutron detector that has the potential of replacing pressurized 3He-t
urrounding material such as lead, gamma ray attenuation can be significant. Neutrons, on the other hand, easily penetrate dense, high atom
zation. Phase I will include a proof of concept demonstration of neutron generation capability. The CNT ion source will enhance the perfor
will then be integrated into DMS ion detection device prototypes and field tested in practical applications. Successful completion of the Pha
ntroller (LNBC) that will cost-effectively distribute information to multiple security domain users across multiple physical networks without

Phase I project. We clearly showed feasibility using microwaves to upset vehicles in Phase I, and in Phase II we will refine the modulation sc
solution, using a single FPGA, against a pure software-based system. The work will form the foundation for subsequent development for de
anner and therefore save lives. DAX intends to show a proof of concept prototype of its in house technology Optima HLS used in the identifi
on capabilities developed by third parties within an affordable yet secure network appliance. SINBAD will rely on an SE-Linux Operating Sys
or proposes to develop a robust, automated iBEAR which is capable of handling large volume of botnets. Leveraging the FirstLight infrastru
nt technologies in that it is not as sensitive to the kinetic energy of the entire moving vehicle and is deployable from a safe distance. Our in

will be described, essential variables will be defined, and the IMAXS design will be developed. In Phase II, at least one linac prototype will
rtise at HY-Tech on efficient boron deposition with LLNLs expertise on the development and testing of the devices to move this technology
the proposed project include: 1) application of existing sensors required to measure physiological parameters such as ECG, respiratory rate
a foot away, and a long life reusable collecting trap. The trap uses dynamic motion to enhance collection efficiency without sacrificing a sim
low dimensional data. Our proposed feature extraction method takes advantage of the theoretically well-founded and established data dim

y vulnerabilities and incidents increases dramatically. In this proposal, Intelligent Automation Inc. (IAI) and Dr. Peng Ning from North Carolin
distributed temperature sensors, DTS. In DTS, an optical fiber is used as a distributed sensing element. Fiber-based DTS is extremely robust

rms. This is accomplished, not by searching for the particular &lsquo;signatures&rsquo; known to be carried by this type of malware, but r
ge shotgun cartridge will be developed during the Phase II effort. The projectile will not require modification to the launch platform, will inc
ples they are presented with. Currently trace extraction is done by manual swabbing, which suffers from severe constraints. The process is
es on each potential target in turn to automatically determine if it is human, based on thermal signature. The combined result is a wide sw
e of shotgun shells. Utility of the Piezer is probably best realized in crowd control situations or riots having high levels of aggression. These s

bined statistically. Toward this end, we will translate several algorithms that have been successful in bioinformatic sequence analysis to the
algorithms. The technology builds on previous DHS-sponsored work in which the company demonstrated an initial prototype hand-held che
t prototype system that can be commercialized. A neutron event triggers a large electron pulse which can then be easily registered by puls
e advanced nanoparticles and assemblies as array sensing materials to chemiresistive devices, with additional pattern recognition engine. T

ould allow identification of SNM. Proposed is an advanced electron accelerator that operates at greater than 100X the frequency of existing
is proportional to the amount of this material between the electrodes of the capacitive probe; therefore, the signal is similar to the attenua
ately 3 orders of magnitude more than the state-of-the-art detection limit (a few piecograms). The proposed V-TEST system is operationally

race-level sensitivity is achieved by combining phase-detection electronics with the NLG ultralarge aperture. Detection on several absorptio
esults. In Phase II, POC plans to deliver a working prototype for laboratory testing, followed by airborne testing, to prove the concept. The H
en to measure thickness or mass in paper, plastics, rubber, and food stuffs in manufacturing and packaging. A system based on low power n

t of a sensor system will allow the real-time detection of a range of compounds from low molecular weight TICs to CWAs and explosives.
veterinary, environmental and human clinical markets. During Phase I, Seahawk demonstrated feasibility of packaging the Talon Biosensor

evel laboratory sources and build relationships for Phase II field testing. In Phase II we will optimize the technology and field test units with
nvide
withfor mitigation, and will develop recommended operating policies and procedures for DMnet users. Commercial Application. Current n
Battelle.

dors and users and results in increased security of control systems. With unique set of expertise in the fields of control systems and remote
n proposes to develop a wireless control system that augments existing wireless technology in order to provide both the ease of plug-and-p
electromagnetic signals to determine soil density and moisture. In Phase I, TransTech has demonstrated that its technology can achieve m
via IEEE 802.11 or Bluetooth wireless connectivity, provide sufficient data processing to compress and packetize biometrics data for global
e transparency of the conditions of their goods during shipment.
ransported globally. The detector proposed will meet efficiency and sensitivity goals and be useful for real time monitoring of background n
ntelligent software and low-cost.
d allows responders to competitively select from various vendors with unique specialization in order to be equipped with the most approp

ons are significant and represent a $3 billion potential market. This includes fire, law enforcement, EMS, other first responders, and federa
ether or not it is desired that the perpetrator know that their actions have been detected. By indicating the location of possible tamper sit
developed in the design of the AbioCor replacement heart has demonstrated excellent durability and hemocompatibility in clinical evaluati

has perfected the technique to make high resolution images of in vivo lungs using a large 1.9T superconducting magnet based MRI system
ong-term and homebound care is feasible and would yield human and financial savings through diminution of patient sequelae and co-mo

d RNA yield by 1) improving the efficiency of T7 RNA polymerase using structure-based engineering with directed evolution of function, 2)
uding height selection, backrest angle adjustment, backrest to axle positioning, and lumber support. The purpose of the proposed research
 ructures in a natural way that can be communicated easily. Recent techniques for graph querying and mining have demonstrated great pro
in the study, but they severely limit the usefulness of the SSA data. New statistical disclosure limitation methods have been developed that
processes. The proposed near term product is a row/column (128 elements by 128 elements) electrostrictive array for volumetric imaging
nd environmental factors, the final death pathway leading to AMD is apoptosis of photoreceptors and RPE cells. We need to identify compo
tantly, however, there are currently no accepted or practical tests for measuring the retinal toxicity of compounds directly. In vivo assessme
cation of the optimal fiber placement and chronic studies of implanting the cochlear stimulator in an animal model will also be conducted.
urveys/registries. To date, MedRIC's activities have focused on linking functional research files derived from Medicare data to NIA-supporte
eys/registries. To date, MedRIC's activities have focused on linking functional research files derived from Medicare data to NIA-supported s
y available for scientific and biomedical research communities to simply conjugate carbohydrate probes onto nanoparticle surface. In this N
analysis of glycomes because of the difficulty to reliably immobilize populations of chemically and structurally diverse glycans. ADA propos

performance for play activities as they require too much cable excursion or operate inefficiently and demand too much cable tension to eff
onists to identify two therapeutic candidates for the treatment of cocaine addiction by assessing: 1) the potency and selectivity of compou
es. In addition, auto-islet transplantation for persons undergoing pancreatectomy for chronic pancreatitis has been performed with increasi
the PA pore, we propose to screen our library of per-substituted beta-CD derivatives for inhibitors of epsilon - toxin's activity. The specific a
Alertness and Memory Profiling (AMP) system integrates neurophysiological, behavioral and subjective measures in a platform designed fo
uring the Phase I study in confirming diagnosis of OSA in a dental setting and in evaluating treatment outcome and assessing titration levels
amount of fuid removed during the treatment, treatment with hypertonic saline, administration of fuid boluses or other agents, and plac
er available at the point-of- delivery (birthing centers). Based on Advanced Liquid Logic's previous demonstrations of digital microfuidic ma
oval is required prior to the commercial sale of the device.
stationary machines that are occasionally visited as time permits. People with busy lives may often go many days between using their com
ng daily activities. This will allow the device to be used in ambulatory epilepsy monitoring applications and will create a larger market for t
. However, intervention strategies have been confounded by the need for frequent assessment of the physical exam in a relatively immobil
m) Lumbar Rehabilitation System. In phase II, we will complete the development of the system and test the clinical utility of a portable, low-
eters and gyroscopes) and standardized personal area networking technologies make the proposed project technically feasible at this time
ly with children, and (2) add noise and/or motion artifacts. Sensors based on the proposed integrated circuit will not suffer from these limi
nvisible anomalies represent valuable, unique indoor terrain features measurable by magnetic sensors located inside a small, portable dev
ss EEG system will make possible for the first time recording single neuron extra-cellular action potential (AP) and local field potential (LFP)
novel targeted therapies. The 88 kDa autocrine growth factor PC-Cell Derived Growth Factor (PCDGF), also known as granulin precursor (G
comprising antigen-coated membranes and relevant antibodies), and to demonstrate their use for profiling AKT signaling in cultured breast
ort peptides which were formatted as a protein microarray for use in a simple capture immunoassay. When probed with a blood sample the

ble. As scale increases, increasing numbers of batches exceed the FDA mandated allowable contamination level of 1RCA/3x10e10 viral par

se range for AdV-tk in brain tumors and some encouraging results. Preclinical studies demonstrate improved efficacy without added toxici
ung diseases and their severity. Aerodyne Research, Inc. together with the University of Massachusetts Lowell, School of Health and Enviro
ODP). Newer MDI devices are now pressurized with hydrofuoroalkane (HFA) propellants, which overcome the ODP problem. New problem
rivative, most commonly artemether, is combined with a longer half-life antimalarial such as lumefantrine to eliminate the parasites and de
lead directly to a marketable pain therapeutic. Recently, many researchers have extracted biological pathway information from gene expre
animal models have long hindered efforts to better understand the impact of long-term partial sleep deprivation. To greatly improve this si
tuses, researchers rarely conduct simultaneous assessments of cognition and basic neurobehaviors such as sleep, known to infuence cogn
on, differentiation, integration and communication with native cells and matrix. New technologies that can overcome any or all of these ob
will allow a clinician to choose from more than one class of antibiotics to load onto an implant at point of care. Using phage display techno
osteoinductive elements especially in demineralized forms. However, these natural materials also have limitations including immunogenic
erman 2003). In contrast, there are only a few basic point-of-care devices to isolate osteogenic progenitor cells, which are the third and tru
nd be able to wirelessly transmit the captured data to a remote server for advanced locomotion analysis. Using specific patented and teste
esis or neovascularization. The heparan sulfate of Perlecan is reported to promote cell adhesion, to promote proliferation and/or differentia
Site-directed mutagenesis to the Perlecan core will establish a valuable precedent. One of the major innovations of this technology is the a
apathy challenge by creating engaging discovery-oriented science learning modules uniquely combining social learning pedagogies with dis
e monitoring for individuals over extended periods of time. The project will develop a wireless enabled device that will monitor the particu
cord their own speech for conversion to a personal synthetic voice for the ModelTalker TTS system. This voice banking capability has alread

id drugs, but have significantly lower side effects than currently used opioid antagonists. Results from this project will establish the feasibili
research, and to develop targeted commercially-supported open source solutions from this infrastructure. It will: Integrate research data
with scissors and scalpels is desirable. This study will initially focus on expanders for use in dental surgery; however the same principles can
diology of the presenting patient, and because single-antibody tests are notoriously prone to false positives. A competitive immunoassay is
y for infuenza diagnostics in clinical specimens based on Akonni's gel element array technology. Specific aims in Phase 1 are to develop and
discovery, but will require sophisticated environmental control to limit variability and increase the quality and accuracy of these intricate an
t optical detection systems for these microwell plates are based on detectors that are a compromise between speed and sensitivity. Imagin
sessment of these proteomic changes should permit the specific and sensitive diagnosis of TBI and continued evaluation of the condition.
ever, current X-ray-to- light converters that provide low light conversion efficiency, low X-ray absorption, and a tradeoff between spatial reso
eutrons are used in macromolecular crystallography to investigate the structure of molecules and proteins, which consist mostly of light ele
be improved by using contrast agents targeting specific cancer cells involved with vasculature growth. Persisting hypoxia in a growing tumo
many are voluntary and most apply only to items that are manufactured for use by very young children six years of age or younger. Unfortun
made fully transparent by conventional ceramic technology. Recently, however, a new process has been developed through nanotechnolog
e role in modern cancer research, clinical diagnosis and oncology. While PET is a powerful imaging tool, the performance of current clinical
microCT. The detector will be based on a new high efficiency, low afterglow, structured scintillator coupled to a modified architecture CCD w
90% of myocardial perfusion studies are now performed using SPECT. The role of PET in cardiac imaging is gradually expanding, particularl
lities for small animal studies into a single imaging instrument that will record data in both imaging modalities simultaneously. The most im
tial resolution, sensitivity, and geometry best suited for the given application. To address these issues, we propose to develop a large area d
id 6532 (in the Entrez Gene database) regulates gene id 836. Software can extract such facts from a sentence like this. But the current state

hancement and detection of agglutination of particles of different origin, including latex, silica microparticles, and biological cells. The deve
in these tests, the technician subjectively evaluates the procedure's results and, consequently, antibody detection procedures are slow, lab
of excessive alcohol consumption, none address neurodegeneration, withdrawal or anxiety. Whereas recently success has been seen in a
nd long-lasting. This Phase II SBIR plan focuses on meeting requirements for short term central venous catheters. First, coating constituent
mmograms. With approximately 1,700,000 women undergoing breast biopsy per year in the USA, combined with a cost between $750-500
r of 55-80 fm (~4-6 cell diameters), therefore, the cytotoxic properties of a-particles are highly focused, which minimizes collateral radiatio
he isotopes are required to support increased research on other cancers that will be undertaken as papers are published discussing the the
an instrument and application-specific disposable cartridges that are capable of rapid detection of multiple target pathogens and biomarke
ing a Bead Sorted Library of In Vitro Expressible DNA (BS-LIVE-DNA) as a template. Additional novel technologies developed during Phase I
most importantly does not easily detect subpopulations of drug-resistant strains below 20%. It is also difficult to link specific mutations to in
of this project is to develop a cost-effective, high sensitivity, non-invasive method for scanning protein truncating mutations in the APC gene
ene. However, a significant problem is the wide variety of NF1 mutations which have been found to occur. Most inactivating mutations (>8
me and transcriptome. Thus, there is significant opportunity to develop nucleic acid assays that correlate the presence of biomarker signatu
nagement of these diseases. According to the American Cancer Society, 34,800 new cases of all types of leukemia were reported in the US

human kappa opioid receptor (KOR), we show that the receptor can be highly overexpressed and purified to homogeneity. However, the p
n the hospital foor. The research will include a baseline phase, during which hand hygiene is recorded but no voice messages are played; a
min before meals to 60 min after meals), the establishment of a dose-response relationship and comparison with metoclopramide (a curre
ll serve as a "hepatic bridge" until transplantation. Significant evidence suggests that scatter factor / hepatocyte growth factor, exerts direc
 ited tissue half-life and exorbitant costs. Using a drug-discovery engine comprising 3-dimensional molecular modeling, phage display, ration
factor (SF), is a pleiotropic growth factor that induces the activation and proliferation of diverse cell types, largely through its mitogenic and
mors including gliomas. Binding of SF/HGF to its receptor promotes growth of both tumor cells and endothelial cells lining the tumor's blood
tly, there is no known cure and the exact cause remains unknown for scleroderma. Treatment options include, relieving or controlling sym
verely affected when afflicted. Infammation and angiogenesis are two of the fundamental processes that underlie pathologic disorders. Ti
he clinical management of SCI. However, treatment modalities that employ gene- or protein-based formulations are characteristically expe
in neonatal children (
ssing tumors and bacteria (Nature Reviews Cancer 5, 796-806, 2005; Proc. Natl. Acad. Sci. USA 98, 9814-9818, 2001). With the help of the
rectly address these shortcomings. The focus of this proposal is to develop the HCVcc system as a more useful tool for drug development. T
synthetic methods for which costs dramatically increase with the length of the peptide product. Another major advantage is the rapidity w
of early to late AMD patients was readily discriminated from clinically normal old adults in = 20 minutes. The difference was both substanti
nctions: inhibition of keratinocyte proliferation and promotion of epidermal barrier function. In particular, it has been demonstrated that PG
tive effects while reducing systemic toxicity through alkylation of vitamin D receptor (VDR) in tumor cells, have shown that this compound
proposed over the years, but none has combined all the characteristics necessary for widespread adoption by physicians and acceptance b
-1-phosphate (S1P) produced by SK within retinal endothelial cells in response to VEGF is critical to the cascade of events that results in the
se of immunosuppressive drugs will be important therapeutic advancements required for the efficient treatment of T1D in the clinic. The m
e to the complex nature of interactions taking place between the immune system and cancer cells in the course of tumor progression. Thes
s based on the use of a proprietary formulation of the costimulatory ligand, 4-1BBL, designed to specifically deliver TAAs/TSAs to APCs. This
rface of APMS can be modified for cell specific targeting and maximal uptake. The proposed research as three main goals: (1) engineer APM
l edge contrast only, which is not compatible with efficient screening of colorless membrane protein crystals grown in lipidic cubic phases.
ative design process will be employed that will ensure the information contained in the interactive multimedia Web based application is a m
ual ABG display was more effective in communicating the status of the pH, PaCo2 and HCO3-values to the user, thus significantly increasing
dels adequately predicted clinical endpoints of interest to an anesthetist and is hence, commercially viable. For Phase II, several aspects of t
r which valve performance will be acceptable. The specific research aims are to (1) develop accurate methods for fuid force calculations on
nically relevant embolic model to validate whether APT102 provides significant neuroprotective effect without increased bleeding risk. Hum
ctivity and platelet inhibition than the wild-type apyrase. With the Phase I SBIR grant support, we will optimize the dose regimen of APT20
es. Our labor-saving automated mosquito monitoring system integrates electronic photo-sensors with computer-analysis software to quanti
yze the data and decipher the patterns resulting from the various exposures to identify the unique fingerprints for each compound. Microa
tion requiring local tumor control with endobronchial interventions. Palliative reopening of the affected airways often alleviates symptoms
s to the current informed process need to be applied. ArchieMD Inc. has developed a comprehensive interactive medical simulation e

equired to aliquot samples, and samples becoming lost, mislabeled, or contaminated with significant frequency. The goal of this project is
nd data mining. However, existing data resources in the field of pharmacology and toxicology only partially satisfy these criteria. Being depe
alginate specific mAbs can be used to reduce P. aeruginosa lung infections and result in improvement in lung function. One key observation
ial delivery system. Conversely, virtually all cells of the brain can be treated with a trans-vascular delivery system that enables the enzyme t
ntially lower capital and running costs and similar or better quantitative performance, including precision, limit of detection and dynamic ra
e use of deep sedation for colonoscopy, and lessen the overall cost of the exam. The CFM prototype development performed to date has a
ch usually penetrates the inner limiting membrane (ILM) and grows into the vitreous. Retinal neovascularization is observed in ischemic reti

gion of the mouse would enable more accurate and repeatable mouse studies. Therefore, in the proposal we plan to develop a robotic syst
son. The patient will initiate the monitoring session by performing a conventional finger-stick glucose measurement and acquiring a corres
heir conjugates, and quantified. Using ATERIS Technologies novel sensor thin polymer film technology, reporter domains will be customize
m the FDA following a Type B pre-IND discussion, this Phase II proposal aggressively pursues those preclinical issues required to advance the
rent literature indicates that buprenorphine is the most widely used narcotic analgesic for rodents because of its excellent analgesic activit

ne by creating two site-specific probes, each one containing one of the PCR primer sites or a complement thereof. These probes anneal to
nual testing, this requirement can add several minutes to the test time. For automated testing, the need to reposition transducers several ti
otics-resistant infections, are no longer efficacious against certain strains of bacteria. It is important to realize, that the loss of efficacy of th
we have developed the FDA approved intraocular delivery systems Vitrasert(r), and Retisert(r): an implant that delivers therapeutic doses t
ng elimination half life of these drugs make them suitable for depot formulation. In previous work, supported in part through SBIR Phase 1
al other drugs and this technology has been adapted to apomorphine. The specific aims of the Phase I proposal were: to formulate sustaine
monary fibrosis. Accumulating evidence indicates that transforming growth factor-beta (TGF-a) plays an important role in the pathogenesis
est this hypothesis, a novel 123 I -labeled radiopharmaceutical, 123 I-IMPY, was developed to specifically and sensitively bind Aa (the chief
C-DTBZ imaging of BCM, the applicability for human studies is limited since the 11 short half-life of C (20 min.) means that C-DTBZ clinical s
tated a search for an alternative approach. Promising clinical results with nerve allografts has prompted research into various methods of p
are used for the treatment of cancers, and is termed "chemotherapy-induced peripheral neuropathy" or CIPN. There are currently no treat
to produce an rBCG that constitutively over-expresses fibronectin attachment protein, FapB. This protein and the attachment to fibronectin
ch a rapid, reliable, and sensitive tool would greatly improve diagnosis and triage of TBI patients, would more accurately guide treatment a
patients with chronic or subacute pain. Success for construct validity in Phase I will be designed by demonstrating the accuracy of the new
re) [59, 95]. This SBIR Phase I grant application is concerned with the detection of developmental disorders at a very early age. Assessment
and efficient administration of pain questionnaires. Multivariate IRT (MIRT) will be used to perform a statistical study of questionnaire item

care industry and are required to monitor the effectiveness of equipment and procedures used. Currently, biological indicators of living mic

parison logic. This proposal seeks to construct a novel hardware-based bio-sequence accelerator, the "smart disk" engine that addresses lim
gram, FCDCU) and integrate follow-up components into the web application so that it has the same features and functions as the CDCU /FC
dictive behaviors (substances or activities), by teaching how to change self-defeating thinking, emotions, and actions; and to work towards
nosed behavioral health problem will be selected (N=400) in 4 research sites representing the diversity of the United States Hispanic popula
th community clinicians and clinical students the utilization of this evidence-based practice. Specifically, the initial aims of this Phase I prop
velopmental modification of the "gold standard" treatment for panic disorder in adulthood (Panic Control Treatment; PCT). The proposed o
ust assay methods for high throughput screening (HTS). To overcome this technical hurdle, we propose to use fuorescence based immunod
roughput System fFCXHTS (Fig. 1) - for high throughput assays of neutrophil chemotaxis in a defined, stable chemical gradient. The project
ique liquid fow properties at the microscale enable the construction of a robust, highly reproducible two-compartment tissue model in a h
d murine pancreatic progenitor colony assay to a human assay based on HuES cells, and 2) to create a reporter HuES cell line with insertion
S. in men in the U.S. in 2005. The objective of the proposed research is to conduct pre-clinical proof-of-principle studies to show that the tr

n than traditional SC-LC training. LC-only training, however, tends to be more specific to improving LC strength than SC strength. Even large
ome P450 enzymes are so homologous that pigs should be the preferred model for drug metabolism and pharmacokinetics studies. Yet, pi

that are capable of performing chemo-selective C=C reductions have been reported; however, limited characterization of these enzymes ha
growth rate of the melanoma. We have also completed a Phase I Clinical Trial using the hand-held BFI to measure the electric field in both
procedure while the patient is inside the scanner can provide a drastic reduction in procedure time, providing increasing patient comfort a
ally-oriented basic life science research productivity by completing a prototype software application, LabmatrixTM. LabmatrixTM will provid
nt on the presence of somatic mutations in EGFR, thus indicating the need for a simple diagnostic method to identify patients susceptible to
mmercially producing of all of the protein components used in pWGA. We will also evaluate the performance of pWGA, including reaction ti
s, using BSA or mixtures of BSA and peptides as a model. 3. Evaluate the performance of this device on an ultrafiltration application in life
in a wide range of scientific investigations. However, a number of fastidious genera are currently not amenable to PM analysis. One princip
is inexpensive, accurate, and non-invasive therefore would be a great benefit. Working with Lawrence Livermore National Labs, BIOMEC h
ertonic saline (HS) (7.5%) resuscitation solution. The approach is based on the utilization of the anti-ischemic and anti-infammatory anti-se
ach is based on the physical and coagulation properties of a mixture of Teleostan Gelatin type A, Polyvinylpyrrolidone, Sucrose and Fibrino
earchers have been forced to simplify the complicated nature of their datasets by reducing or eliminating the spatial or temporal dimensio
of geographic and ethnic variations in cancer stage at diagnosis and survival data, and the exploration of relationships between health out
sidential addresses of cases and controls. Exposure traces that account for the latency between exposure and disease manifestation, and t
ications or other timely therapeutic options. Elevated and fuctuating IOP over a 24/7 period is an independent and proven risk factor for e
t data in a timely fashion. As most disease related loci are located on specific chromosomes, it is of great value to be able to pre-sort th
ethods will allow the rapid production of recombinant peptide antigen/immunogen conjugates while eliminating both the need for chemic
ment of Lyme disease limits or prevents serious damage to the systems affected. Current serodiagnostics lack sensitivity in early disease. Th
Lyme disease would decrease. To accomplish this, we developed an OspA-based bait vaccine and demonstrated that, in the Lyme disease m
ctice guideline by the National Kidney Foundation. Monitoring changes in glomerular filtration rate (GFR) provides the best means for early
imaging and magnetic resonance imaging. This Phase II application seeks support to optimize the labeling of cells with IVST materials, to d
er utilization of this diagnostic tool. Our Fast Track SBIR application will evaluate a gadolinium-based contrast reagent that is ideally suited
alization of TL1A has been reported in infammatory bowel diseases and atherosclerotic plaques thus indicating that TL1A might play adver
eover, the level of DcR3 was significantly elevated in human cells in response to bacterial antigens and in sera of patients with bacterial infe
gnal-to-noise ratio of the older technology places severe constraints on the range of subjects which can be successfully imaged. In order to
T-NIAID, which called for the advancement of assays for infectious and immunological disease diagnosis on novel advanced technology platf
s. The specific aims of the proposal are to: (1) Use long synthetic gene gorging (lsGG) to replace a model singe-gene target in E. coli with va
rescent signal is generated only by uncoupling of the fuorophore and quencher, the probes' have nearly undetectable background signals.
population) potentials to be captured without unrecoverable distortions. These (and additional) innovations of DT can overcome the techn
s and a high degree of consistency of pronunciation of the speaker. Many AAC users cannot meet these requirements because they already
ngs have led us to hypothesize that there is a protective biofilm of bacteria adhering to the Ileocolonic wall and an invasion of this protectiv

), the applicant organization, is proposing to use two communications technologies - Black radio and the Internet, to raise awareness and im
very of fine respirable aerosols without shear-stress-induced molecular degradation d) administration of sparcely soluble agents and e) del
omal RNA fragments. By generating base-specific RNA fragments optimized for mass spectrometric characterization, we have shown that "
in diabetics. BioTex, Inc. has developed a superior concept of a minimally invasive fuorescence affinity glucose sensor which is one of the
ptosis, early detection of apoptotic cells and monitoring cellular apoptotic process kinetically. The overall goal of this Phase I SBIR grant ap
., is around 50%. In other words, for every16 channel chip used in these systems, only eight will produce useable data. This effectively doub
thout the user having to point the device directly or accurately at the target as with optical telescopes. The Smart Telescope is small and lig
his project is to develop a complete computer assisted surgical planning and navigation system for total shoulder arthroplasty. This will allo
eron-gamma products. During Phase I we identified sites in interferon-gamma that can be modified with a polyethylene glycol moiety witho
pment of the vascular system in the synovial lining of the joints and therefore, is a reasonable target for therapeutic intervention in RA pati
doubled in the wavefront by refection, this will require a DM with at least 6fm of stroke at each actuator. A second goal will be to demons
w to large volumes of alveoli. The novel diagnostic device, the Carboximeter(r), measures the effect of high-ventilation, low-perfusion mism
t could render these devices inherently resistant to biofilm formation and encrustation could significantly reduce the incidence of infection
genic bacteria usually re-dominate the Dental plaque after the treatment and start another cycle of cariogenesis. This study proposes to de

e world's leading scientists. There is a desperate public health need for proteomics, quantitative chemistry, pharmacogenetics, and others
oxicity in the human population. This provides valuable information involving metabolic pathways for the Gene Environment Initiative (GEI)
ecific proteins or specific protein assays are not required. Caldera Pharmaceuticals has 2000 square feet of lab space and 1800 square feet
thesis because pathology studies consistently indicate that aberrant protein aggregation is a cardinal feature of the clinical disease. The ove
creen for compounds that increase the expression of DJ-1. In preliminary experiments, we have constructed neural cell lines that stably exp

oping a microelectromechanical sensor technology that allows rapid, relatively inexpensive, non-invasive point-of-care evaluation of this p

STTR support enabled the Applicants to begin translation of these findings to humans. The critical first step was successful preparation of
 irreversible cardiomyopathy and congestive heart failure. The controlled, sustained release of chemotherapeutics from biodegradable PLG
een to demonstrate the effectiveness of such monitors. The critical issue that needs to be addressed is the development of algorithms
t adequate for widespread clinical training in the BASICS model. Cascadia Addiction Research and Education, LLC (CARE) is committed to the
osis. In concert with this down-regulation of pro-infammatory signaling, cultured microglia isolated from HUCBC-infused PSAPP mice dem
rine progenitor cells. This proposal is a feasibility study to determine the commercial reality of this technology. The research proposal is div
man lung cells (hLC) and tissues beyond those typically realized today. Investigations conducted under this research project will utilize cDNA
splatin) treatments. This approach has recently led to the initiation of a physician sponsored IND for the treatment of advanced stage pros
rostate cancer. This Phase I project proposes to develop a novel therapeutic device (Neuprosol") for the protection of the neural vascular b
ation sites that could become targets for cancer diagnosis and treatment. During Phase I we will establish the method and its tools, using a

e. Using tandem mass spectrometric methodologies, the CST Cancer Biology Group and others are discovering thousand of new phosphor
injuries during clinical trials. If CellASIC's product is successful, a 10% improvement in predicting these clinical trial failures could reduce th
odel has not been developed so far. To address these issues, we will develop a novel experimental platform for cell-based HTS of peptide dr
To address these issues, and to expand on previous program funding, we have developed a novel experimental platform to construct functi
allenging and significant limitations in the technology exist. To address these issues, and to expand on previous program funding, we have d
ogenitor pools will protect against XRT-induced injury by the replacement of hematopoietic precursors and immunomodulation of the gastr
umn-purified virus will be evaluated in terms of its purity using an array of QC tests, and immunogenicity using animals. The fu virus purific
e are primarily based on HIV viral load measurements: when to initiate drug therapy and when to switch or adjust drug therapy regimen. Si
sing either animal cells or heterologous expression systems have limitations in their predictive capacity, and typically multiple assays are em
e pharmacist opens the prescription vial and examines the appearance of the pills. If the pills in the vial appear to visually match those in a
d sensitivity. Traditional spectrometers sacrifice sensitivity for spectral resolution and are not amenable to miniaturization. However, Centic
res often results in missing elements. To overcome these issues, TRS proposes to make multilayer single crystal 2- D arrays utilizing a new p
t clinical significance. In Phase I, TRS Technologies and Penn State University developed a micromachining method to create composite pie
e discovery of a wide range of anti-infective drug leads. While macrolide semi-synthesis has allowed for the production of a number of seco
The necessary IP to pursue this goal has been exclusively licensed to Centrose by the university. Two leads derived from digitoxigenin have
primary objective of this proposal is to use state-of-the-art perfusion technology and new preservation solutions to test the hypothesis that
analyze multiple images with different combinations of illumination type and color. Analysis of the images will provide all the conventional c
plicitly expressed a desire to have in vitro robotic assays for EDs, such as anti-estrogenic activity (anti-EA). However, no robotic anti-EA assay
F signaling or VEGFR have initiated a major research effort with potential of producing novel, potent, efficacious, and marketable drugs for
is developing the first eyedrop-based therapy for treatment of the aforementioned conditions, and has achieved significant commercial m
or incentive and research effort for the treatment of DME. Thalidomide and some of its existing analogs have displayed anti-angiogenic acti
human leptospirosis is an under-recognized disorder. To date there is no effective prevention for leptospirosis. Leptospiral infections can be
ning high sensitivity and reliability, is designed to make gene expression profiling more accessible even to smaller clinical or hospital labs by
ovel inhibitors of ACC2 as lead compounds for the development of new pharmacotherapies to treat obesity. We have constructed yeast gen
r capacity, good selectivity, and enhanced robustness compared to conventional technologies such as ion exchange, activated alumina, and
x-derived candidate biomarkers of premature cervical softening. Our hypothesis is that these candidate biomarkers will be consistently det
methods in the rapidly evolving domains of social simulation, cognitive modeling, virtual environments, and intelligent tutoring. Those line
erent conditions can be used to measure the production of specific cell products in real time to assess immune cell functional capacities. T
mples on the basis of parallel detection of multiple biomarkers, which when interpreted as a pattern will result in highly predictive and accur
mportant consideration in T1D and is often a limiting factor when testing clinical samples, especially as young children and adolescents are

essy" substances typically used in preparation for the hookup. Surface EEG recording is the standard of care for most non-invasive brain mo
rkers currently exist for antemortem PD diagnosis. Diagnosis relies upon presence and progression of clinical features and confirmation on
epilepsy or intractable brain tumors. Every year millions of dollars are spent by pharmaceutical companies to develop alternative pharmac
dynamic nature of the Internet is an ideal way to deliver such an intervention. This project will utilize our expertise in Internet technology,
d one- hour modules on the assessment of suicidality in youth through an NIMH-funded STTR Phase I award (1 R41 MH073197). Data from
oposed in this application, with an emphasis on identifying a back-up compound. Compounds within the series with particular receptor sele
infammation and dementia in patients with CAA. Cerebral microvascular, but not parenchymal, amyloid deposition is more often correlate
xist. Specific Aim 1: Using a C. rodentium-infectious model of acute colitis, measure the response to treatment with different doses of COG
everity of PD increases. Any new treatment that provides neuroprotection and eliminates neurodegeneration would provide a fundamenta
opulmonary bypass. Cognosci Inc. has discovered an anti-infammatory peptide known as COG133 that was demonstrated to suppress activ
eloping apolipoprotein E-based remyelinating agents is derived from our unique understanding that 1) apoE is the principal apolipoprotein
ctional recovery, decreased histopathological signs of disease, and reduced the relapse rate in two experimental autoimmune encephalomy
ould resorb in the timeframe of naturally healing bone. The long-term goal of this project is to create a resorbable small bone adhesive wh
iring direct contact with the tissue. The hypothesis of the proposed Phase I research project is that Cohera's proprietary biocompatible pol
n normal mouse skin. They enable resident DCs to process antigens injected into the skin without endogenous adjuvants, and cause the D
roposed project will develop a system for comprehensive assessment of perceptual problems and for comprehensive, structured auditory t

d. Leaching studies have shown the CMS membranes to be stable. Based on results and commercialization analysis the CMS system is seen

nhibiting glucose uptake from the intestine by interacting with the glucose transporters SGLT1 and GLUT2. These results warrant further inv

dized outcome assessment of patients with either monolateral or bilateral CIs in the clinician's office, without the need for a sound room o
ombination, mass spectra of exhaled breath, covering the entire mass range of chemicals of present interest, will be obtained by employing
varying from 7% (Bowsher, Rigge, & Sopp, 1991) to 40% (Brattberg, Thorslund, & Wikman, 1989). Estimates vary by type of pain, ranging f
biologically significant systems requiring the mPBE-based level of physics modeling. Distribution of this software will allow researchers and
re conducted to measure the biostability of solder formulations, evaluate tissue bonding strategies and compare wound stability as a functi
low power broadband white light source, the diffusely refected light is collected, and the refectance signal is analyzed to calculate hemog
an lead to major tissue deficits. Reconstruction of the lower jaw typically involves bone, gingiva, and teeth. Current mandibular distraction

t (LL-FDI); (2) compare the accuracy, response burden, and sensitivity to change of the prototype LLFDI-CAT with the full-length LL-FDI instr
as onto and off a bed under which there is no room for the base of current lifters. Current options for tub transfers require major installatio
stage. They suffer from limited specificity, low resolution and conficts of interest which in turn lead to patient confusion and perceptions t
ise opportunity, and providing the spinal cord and brain with targeted afferent feedback that may aid in restoration of function of the affec

for patients with respiratory failure has been shown to lead to increased methemoglobin levels, since the inhaled nitric oxide can combine

d product does not remain associated with the cell. The novel laser-enabled analysis and processing (LEAP(tm)) technology platform for hig

acing of an entire joint instead of a focal defect. We will create a hemispherical layer of cartilage that replicates the load-bearing properties
anisms. The identification of additional agents that enhance immune-recognition is of great potential benefit for immunotherapy, and ther
ting synthetic EET mimetics and have identified a lead compound that we will use in this Phase I application to provide evidence and ration
rived from other tissue, such as blood or marrow, frequently exhibit impaired number and/or function in persons with risk factors for vascu
timal NMR performance. In addition, initial tests of a high through-put strategy for solving structures by X-ray crystallography or by standar
ege applications, and searching for an apartment especially challenging. The Individuals with Disabilities Education Act (IDEA) mandates tra
eracting with groups and individual/family/couple clients around substance abuse confict resolution issues, visual aids, and evaluation form
due to the secretive nature of the disorder. TTM is one of the more obscure, understudied, and undertreated psychiatric disorders. People
1993; Knitzer, 1996). Unless we can improve the involvement of families in mental health services, those families most in need will not be a

youth treatment programs (Dennis, 2002; Riggs, 2003). Youth LIB will serve this purpose by integrating research-based approaches into a re
 mpact of specific cause pathway on health outcome. Since the records in each cluster are often correlated, investigator has to adjust the h

re particularly vulnerable to poor adherence and its high costs. Even teens who experience comparatively mild symptoms of CF must follow
members-is an innovative concept in that there are currently no available video programs specifically designed for family members affecte
ques, engaging and developmentally appropriate content and multimedia tools to ensure effective use of the curriculum in the classroom.
ticancer profile in xenograft studies. 3. Develop the analytical assays required to document purity and stability and develop/validate protoc

he module. Pilot test the revised module as to the ability to increase knowledge in and impact on both formal and informal caregivers. Eval
earchers outside of China. This valuable and unprecedented data source reports more demographics, down to smaller geographic units, tha
nt of a unified MIS instrument system will consist of: (1) The fabrication of an endoscope visualization system that overcomes the clinical d
d guests, and need the same knowledge base provided by RBS training programs to public servers. In addition, special risks to minors and th
they are often the first health professionals to observe overt health effects. Although dental professionals believe they have an ethical obl
able drug against malaria. This will be accomplished by producing a panel of varied bRCQ structures, and then testing them against chloroq
IS output. A subset of the HRS data will be incorporated into a system that generates profiles of a given area's health, retirement, and othe
ies on the DRW HBsAg rapid test, with the ultimate aim of meeting the requirements for pre-market approval (PMA) by the Food and Drug
This technology also simultaneously creates affinity reagents for each of the identified difference proteins. A patent for DCP has been issue
etween the two samples, leaving affinity reagents against the difference proteins. These affinity reagents are used to purify the difference
a from patient use-case scenarios. Innovations in dynamic and personalized content will be implemented through this study. Phase II of this
andard clinical depression rating scales. The phase I will begin with a first user study to give use case scenarios on the design of SPIMA and
ments of E. coli 2-gal termed Enzyme Acceptor (EA) and ProLabel. Individually EA and ProLabel show no enzymatic activity, but when co-exp
ear the amino terminus, while the smaller fragment, ProLabel, contains the amino-terminal sequence missing from EA. Alone, EA is inactiv
s, this project has high-impact potential because the techniques we will develop can be used for treatment of multiple diseases using a 'un
t) and a transposase that catalyzes excision of the transposon at the ends of the IR's and then integration into host cell chromosomal seque

ble to the hearing conservationist, and it is the only quantity that is directly related to the potential of noise-induced hearing loss. Phase 1
voir of parasites (macrofilariae) survive and can remain in the body for a decade. In addition, the extreme selective pressure of mass treatm
d-lens elements are controlled electrically and permit the individual focusing of each miniature microscope during scanning of tissue and c
ificity typically depends on BLAST (Basic Local Alignment Search Tool), which is intended for determining sequence similarity and evolution
red locally. In Phase I we have demonstrated such a gel, and employed our optical scanner to record the color distribution in three dimensi
/N gains for many single- resonance applications are expected to range from 2 to 5, and will often be greater than the gain in going from 4.
nificant advances in the needed probe hardware in more than a decade. Several of the world's most prestigious and successful researchers
lly integrate devices with instrumentation commonly found in chemical laboratories and hospital/clinical-trial environments. Priorities will
nd semiconductor with outstanding charge collection properties. The proposed detector is a thin film of polycrystalline mercuric iodide for
nerated from the x-rays are integrated in each pixel over a time before the integrated charge is read out. The use of these current-mode de

ships over longer time period from spontaneous fuctuations under resting conditions. We will apply the MMPF method to the assessment
erred to native and genetically modified E. coli hosts. In Specific Aim 1, both the E. coli strains currently used for complex natural product p
nificant drawback of diamond machining is that it can only machine very limited materials called diamond machinable materials. It cannot
lications in the determination of optimal energy requirements, especially in preterm infants. Most importantly, because of the significant a
, point-of-care device to aid in diagnosis during a patient visit. This device will help individuals with chronic wounds receive appropriate tre

p innovative mycotoxin sensors based on allosteric DNAzymes, which are catalytic DNA molecules that are activated by binding of an analy
a and Tannerella forsythensis), is sequestered as a biofilm in plaque or tartar during infection. Delivering therapeutic doses of antibiotics or
of the non-glycosylated cationic protein expression in E. coli requires very extensive denaturation and renaturation to refold this disulfide-r
gh concentrations, and at physiological temperatures. Briefy, denatured proteins are captured by the chaperonin as a stable partially folded
each segment of the programs. Segments will include an overview of the strategy, rationale for learning and purpose of using the strategy,
II, a preliminary laboratory apparatus that combines all elements of the system in a basic form will be evaluated. This program is a collabor
mited in two key areas to maximize the information that can be gained from studying these channels. First, current systems cannot achieve
research. In this Phase II project, the company will research twenty stand-alone experiments ("Science Path Accelerators" or "SciPacs(tm)")
ution. As the sensors are tuned to the analytes of interest, interferences from more concentrated chemicals is limited. In this program, the
aining one or more of these protein analytes. The protein analytes in the mixture would form binding partners (e.g., antibody/antigen comp

ished company that creates and markets cardiac MRI software. We already have had interest expressed in our plans by one such major com
privacy/legal hurdles, and assessed feasibility in a small pilot study. Each of these specific aims was met. In phase II, we will evaluate the sy
nome," or collective genome, of a soil microbial population. Traditional drug discovery methods require laboratory cultivation of microbes
e device makes patient mobility and wireless connectivity possible. The device's effectiveness in comparison to gold standards will be teste
of need for adaptation, and persistent issues related to implementation fidelity. The approach in this proposed project and the product bein
on will be driven by local data-based planning (e.g., SAMHSA's SPF initiative), this critical step seldom takes place because the resources and
he acoustic characteristics of the synthesized speech. VG is aimed at an underserved population - individuals who cannot use their biologica
rgery, and only examine less than 1% of the tumor margin. Our long-term objective is to develop a chemically specific and quantitative mu
olic agents are difficult and dangerous to use in inexperienced hands contributing to general skepticism of these agents. An easy-to-apply,
mately obliteration. The major limitation of microcoils was underscored by autopsy reports compiled indicating incomplete obliteration of m
to realize a commercial biological soft x-ray microscope. Energetiq has developed a unique light source technology using an electrodeless, i

mpacts. In the proposed project we will customize our aerodynamic lens aerosol concentrator technology for use in a portable air samp
such as Bangladesh, where over 70% of drinking water wells contain toxic concentrations of arsenic. Specific Aims of the Phase II program

to wear headset, and viewable on the same monitor by multiple people have the same time. A standard controller will allow visitors to nav
on a diminishing supply of human source material with ever-present risks from emerging or surreptitious infectious agents; 2) Production

ance is calculated. APD is simple in operation, requiring only normal breathing for one minute and is useful in children as well as adults. AP
ndom integration, and cannot produce gene targeted transgenic animals. The purpose of this SBIR project is to establish germline compet
ent of PK activation regulates the amount of FXII activity, and thus inhibition of PK would provide a novel anti-thrombotic therapeutic appro
rsity sources: recombinant antibodies, and recombinant small peptides. Each addresses market needs not satisfied by murine hybridomas.
modality, immunogene therapy, has shown promise in the spectrum of agents utilized against brain tumors. A specialized polymer delivery s
component of tears, lacritin not only stimulates the cornea/lacrimal gland axis to increase tear production, but also promotes the growth
M technology, Epitome has developed a systematic methodology that allows for the detection of virtually any splice variant within the pro
. The assay will combine current point-of-care (POC) methodologies ("lateral fow") with a proprietary and inexpensive means of creating a
tions, we seek to develop the optimal vaccination strategy, using HLA transgenic mice as the model for in vivo study. Before the start of the
tic Factor VIII therapy without the interference of neutralizing antibodies. Neutralizing antibody formation, the root cause of FVIII therapy
rospray ionization - chiral ion mobility spectrometer - mass spectrometer (ESI-CIMS-MS). The proposed system can not only separate chira
ysical and medical scientists who are evaluating use of a mini-gas chromatograph (mini-GC) device and exhaled breath condensate (EBC) co
containing it. MAMS will include hardware and software capable of recording the detection of the "taggant", storing the information for lat
es. Novel and proprietary gadolinium (Gd)-containing nanospheres developed by Luna Innovations (Trimetaspheres, TMS) provide a pl
pecific kinases of interest in cell-based kinase assays. For this phase I program, we will develop and validate the reagents for two prototype
th craniofacial surgery. The proposed approach is based upon preliminary work that has shown that 1) viable mature adipocytes can be iso

ave emerged which directly impact FAS as a biomarker for cancer: [1] FAS elevations have been found to occur in the blood of obese subjec
bers of mutants in order find improved strains. Because of the transposon tagging process, these improved mutants can be easily reverse e
ounds including other antibiotics, anti-cancer com- pounds, and immunosuppressants. For the last fifty years strain improvement has been
UCBf) in neonatal plasma was produced from a fuorescently labeled mutant of a fatty acid binding protein (FABP). The specific aims of Phas
rs per year in the United States. A well- established reason as to why diabetic wounds are tough to heal is that they do not progress throug
oundation for Applied Molecular Evolution and Firebird Biomolecular ("We do not make DNA assays. We develop chemistry that makes DN
th largely unknown health effects. Despite numerous studies implicating PM in various disorders including acute respiratory infections, lun

em with at least 5 nurses and 25 patients for a minimum of 50 nurse-patient encounters and establish a baseline of system accuracy. Pha
with Monte-Carlo code that models light propagation in tissue. Using articular cartilage constructs as a model system, our team will demons
ew fuorous linker (2-chlorotrityl) will be prepared, and general procedures to prepare peptides with fuorous tag at either N- or C-terminus
d and manipulated individually. This platform also enables real-time electrical and optical monitoring of each cell's response. Three importa
are threatened. This Phase II application seeks funding to build on the successful tasks of Phase I, in which the SSP and ESSP assessments a
s unable to detect or respond to changes in IOP and frequently fail. With either approach, a patient office visit is required for the physician
istance against cellular functions required for viral production. Functional Genetics proposes here to use its proprietary technology, Random
tient comfort and picture fidelity. Examples are the reduction of blurring for human anatomies in motion, such as the heart and lung, and th
et for androgens is growing at a 25% compound annual growth rate (CAGR). Of specific relevance to this proposal, it should be noted that t
hedonia, there is currently no antidepressant that potently blocks all 3 transporters. It is likely that a drug that blocks all 3 transporters wou
hreatened; the ability to anticipate what is going to happen next; access to alternative responses to counter current and future attacks. In P
theory will be deployed to a well-verified finite element code, PZFlex . This development will enable us to test the AMM theory on submar
will integrate the RKPM meshless method for simulating target materials with the NLFlex finite element code for the penetrator to perform
tems Inc, will initially develop a Toolkit focused on the Langevin (sandwich) class of transducer, for consideration for use in the AN/AQS-20
eal active material for PDE fuel injector actuators. WAI will design, develop and test these new injectors in co-operation with the Departme
et and schedule limitations of an SBIR Phase II program; and 3) a development platform for the algorithms that match (or correlate) the rec
se to use the MAZ computational fuid dynamics code and available experimental data to categorize the appropriate waveforms and then re
ror correction mechanism. The character of the waveform is governed by a set of parameters that will change to compensate for increasing
systems. During Phase II, Western DataCom will implement this design into Internet Protocol Encryptors and demonstrate all critical comp
r micro-pitting is proposed for more relevant testing for high power density gear technology.
at risk. In this Phase I proposal, we provide a description our proposed measurement suite, a bioluminescence contrast model, and a conce

STS’ Phase I technical merit through the Phase I work and final demonstration. The Accu-MiSTS project will provide SOCOM with a small, ro
at is able to make router and routing-protocol decisions and adapt the choices to changes in attributes of participating networks. An approa
onics and weapon integration design approach. To support such a model-based process, fexible modeling algorithms for weapon control s
Technologies. That temperature sensor is designed to be formed directly on a superalloy blade and measure the surface temperature at th

tion leakage problem. It needs to work with both currently available as well as future distributed systems and that it need to be adaptable

n, and networking subsystems in a single System-on-a-Chip (SOC) package. The wireless nodes can also be networked using mesh routing p
Williams-Pyro’s Intelligent Energy Control System (IECS) addresses this need with an innovative power electronics-based system using distr
c sources of interest (speech, vehicle noise) and background noise. When a valid target is detected a sound snippet is sent to security perso

esigns will be documented in a source control drawing (SCD) and individual component specifications will be drawn. A master test plan (MT

has a useful propellant mass fraction. A further objective is to look at the trade between thruster types for a larger, more capable, higher t
opellant because the catalysts no longer work. Adding oxygen to desensitized nitromethane and using spark ignition, making it a true bipro
ss of machines. Both can be applied with minimal or no change to the overall electrical/magnetic design of the machine. Applied individua
standards compliance and provides run-time analysis, monitoring and debugging support for both waveform and platform software execu
tems. Second, additional work that could be carried out during development will augment the baseline development effort and further sup
ugh at dynamically variable blending ratio in one system and can switch back and forth seamlessly to combine their advantages. Additional
affecting security policies and certification as executable models to produce high fidelity, repeatable and readily communicated artifacts an
he cost and risk associated with the design/certification of high assurance computing systems. We are able to represent the properties of c
diverse stakeholders to effectively communicate and share information throughout the system lifecycle and provides tools that enable req
y handles 30 frames/sec video). The complete imaging system will be contained in a 4.75 inch diameter by 12 inch in length cylinder or sm
K, and QualNet. Feasibility of the proposed tool development approaches will be shown by demonstrating the integration of various softwa
ng converged IP network model. The proposed toolset will consist of four major parts: Communications traffic and analysis modeling, SATC
ata to support both daytime contrast CCD imaging opacity measurement and nighttime operation, via the "lidar equation." If in the field it
sands of ALE-47 electronic countermeasure dispensers widely deployed across multiple DoD manned and unmanned aerial vehicles. The m
om the Government sponsors. In higher fidelity, each approach will be modeled and analyzed as separate solutions and together as a total
aluminum hardware, would result in significant increases in energy density and specific energy. While YTP has initially looked at some of th
fighter, with a natural transition path from the legacy PLGR and DAGR units. Yotta's modular, extensible approach will bring consistently relia
ction (LPD) techniques. Because the proposed SBIR solution can be built around an existing Yotta divePDA solution platform and architectu
 ciated with bringing a new product to market.

strength to the particle while maintaining the nano-structure within the particle.

ltage (5V) olivine-type phosphate cathode, and a suitable electrolyte system for high energy Li-ion battery.

or military applications.
ural phenomena, such as tsunamis and surface manifestations of bottom topography, in available satellite imagery; to verify the model thro
ntages of the proposed lithium-air battery include: a safe design, high energy density, a lightweight design, and a high energy density catho

ff detection distance from ~10 m to over 30 m.

eed of sound, enabling fast saccades between targets/views. In Phase I, Ziva/UCSD will conduct a feasibility study for the concept design fo
T cases, including strained/unstrained structures and under gust/pilot-commend excitations for the impacts of nonlinear aerodynamic and n
grid (GBCC3D) method will be further developed to include a viscous option and the separated-fow option adopting the vortex confineme
ck vibration and pavement unevenness, (4) the two-point measurement cannot get the defection basin, (5) the error from support beam b
fied compounds. The Phase I option will produce a detailed design for field-deployable prototype threat sensor to be prototyped in Phase

-2590 and will lower cost, provide improved safety, and increase rate capability so that fewer BB-2590 packs can be used in applications su
slation during deceleration. Ultimately, this design led to a total required braking distance of 11 feet, which fell short of the goal of 9 feet, b
Te FPA’s cannot be overstated. In this SBIR Phase I project, ARI will demonstrate a prototype system for wafer mapping for use by the FPA p
cess, Aspen will transform conventionally engineered liners into augmented aerogel super insulating gloves with outstanding dexterity and

eloped by L3, our DEC teammate. Phase I will include simulation and modeling of feasible designs, process variations, subthreshold leakage
s the Firescout, a Vertical-Takeoff UAV. The specific tasks we would carry out under the Base project include: (a) High-Speed Operation of t
r layers while preserving underlying layers and the substrate material. The technology can also be adapted for controlling other coating re
ctively, and easily. It will be suitable for use indoors with no health hazards or irritants produced. Advances in efficiency over currently avail

gy to improve operability and yields of LWIR/VLWIR FPAs manufactured in LPE-grown HgCdTe/ZnCdTe. The program involves development o

recoupled fight simulator will therefore mitigate or eliminate simulator sickness. We have found in our studies to date that there is a variab

akes advantage of a novel braided material for strength and passive conformability with thin layers dedicated to wearer comfort. This new

structural netting such as the ULCANS and LCSS. A significant amount of testing with relevant vectors will take place to optimize performan
e II, we will have demonstrated our measurement techniques in a ground-based dynamic fight simulator.
cation, and evaluation of a laboratory prototype of the device. In Phase II, the development efforts will be expanded to focus on device de
detection of the pg quantities of PrPsc /mL directly in bodily fuids using uniquely specific and highly affinitive DNA aptamers developed us

vative approach to meeting the requirements called for in the solicitation. At the conclusion of Phase II, we will have a pre-production vers
e that attenuates bone-coupled vibrations. This device is designed to work with traditional hearing protection to result in a complete system
t. The seat is stowable, and its weight is minimized for its sophisticated structure. In phase I, we will further develop our proposed concept
tance to radiation, optical transmittance and charge dissipation. Thermal shock durability and near-zero outgassing will also be demonstra
omatically find and align the maps covering that region, and then overlay selected layers from the map to better understand the informatio
aging purposes. The subaperture processing not only reduces the size of the data for analysis but also is the key for the hardware (RF) impl
rther synergistic weight savings. The Phase I program will demonstrate the feasibility of these new synergistic composite conductors and
 turing endeavors are scheduled to begin in the Phase II Option period.
ptions presented, for detailed design in the Phase I Option and development in Phase II. Limited lab testing and demonstration will be perf

ools intended to aid in data analysis and test execution. Phase II Base efforts will take these modules to the next level where they will inter
t reports, field intelligence, and cultural factors that all play a role in determining the inherent risk to our troops while executing day to day
puting system for further processing. Our system is composed entirely of solid state elements and does not come into contact with the sen
eveloped. The Phase II program will culminate with a round of reverse engineering challenges, which will demonstrate the efficacy and su
Consciousness (G-LOC) is a serious problem affecting even experienced pilots. While a well-performed anti-G straining maneuver (AGSM) c
repared uniquely structured coatings on metal test specimens. Erosion testing revealed superior high-temperature resistance to erosion by
in Phase I. The Option Tasks will focus on the actual integration of the energy harvesting and propulsion systems into a representative sen
nie Gallimore. In addition, a complete tracking and orientation system will be assembled and tested in order to best position our sensors fo
pective and the latter providing a ‘top-down’ approach assessing group relationships with central government(s) and structural/institutiona
a at the electrodes, promote good morphology of redeposited Lithium metal during charging, and protect the anode from chemical reactio
that different generations of optimized systems will be tested on actual solar cell systems to evaluate survivability after a simulated attack.
ue, neck strain, injury due to egress, and the system’s effectiveness. Infoscitex proposes a solution which addresses the most important iss
hrough the cold plate. The proposed scheme can not only maximize the power generated from any given thermoelectric or other solid stat
semiconductors and to manufacture radar arrays with greater than 100 channels within essentially a page sized format. The constituent m
domethacin) in rodent models of joint and nerve infammation, post-operative incisional pain (to both mechanical and thermal stimulation

ward not only selecting the right metal system, but also an organic system that allows for environmental stability of the fake while maximi
FC and thermoelectric technologies to maximize the efficiency of a portable power generator with 250Watts of net output power. A labora
veral samples to the Army for chamber and grenade testing. Teaming will be with Clarkson University, a legacy group in the Obscurants res

n. In the proposed project, relatively low refractive index of the NLO polymer will be increased by TiO2 nanoparticle doping as well as com
ta from mature, robust, commercially available vibration and ODM sensors into a versatile Engine Health Management (EHM) system. IAC h
s produced have been demonstrated to be ready for PCR without any additional processing. The rapid nucleic acid preparation method co
tional resources. The U.S. Air Force recognizes the need for technological breakthroughs to support this high-throughput, compute-intense
action of external fields and thereby the requirement for electrodes is removed. The resultant magnetic field confines the plasmoid propel
will be down-selected based on criteria such as limiting threshold, response time, low intensity transmission, and dynamic range among oth
ty for 24/7 vision enhancement capability. The power consumption of this arrangement is expected to be about 2.5 W. Unit size, weight an
ill be key to alleviating concerns by our deployed forces and allies about the these complex engagement decisions. Due to cost and hazards
changes to the real-time operating system running on the IAC-1044 as well as the windows applications used to configure and monitor the
ogramming model using ANSI-C and MPI (message passing interface) API. This provides reduced life-cycle costs and future proofing of hard
t possible with current approaches. Lastly, this advanced monitoring and control will be integrated with commercial power supplies to pro

missiles. Phase I will develop State-of-the-Art FFL models, validate them against known data, and create a simulation tool for modeling the
coating that also actively mitigates tin whisker nucleation and growth through chemical interaction with the tin oxide surface. Vista Enginee

nvironment for multidisciplinary analysis modeling and mesh generation. It employs an underlying object-oriented architecture with a com
ns. Validation of the PHM concepts and the computer simulations used will be performed with hardware using an F-18 generator as the te
service failure time data to evaluate the distribution of the stochastic parameters of the degradation model and (b) test a hypothesis about

etection algorithms; exploring mechanisms for integrating vehicle telemetry information and other contextual information with the detecti
and very long shelf life of over 20 years. Extensive dynamics modeling and model validation tests have provided the means to optimally de
ate vehicle; conduct demonstration surveys at ARDEC on a moving vehicle.
During Phase II, we will also evaluate the interoperability of our framework with 802.21 MIH, and make technical contributions to the stan
hus, an RFID system with the ability to monitor the condition of the medical shipments in transit is of vital importance. In the Small Busines
nd arrays for infrared imaging applications that will complement any future DARPA efforts.

now proposes to adapt the design approach to rock coring, using the demonstrated performance and advantages of rotary percussive drilli
ng of a biomass combustion chamber, a Stirling (i.e., external combustion) engine, and a multi-cell rechargeable battery; and (4) a platform

feedhorns, amplifiers and detectors, and to demonstrate the system on a manned aircraft that will fy lower than the designed altitude. Th
epts, as well as their various components to determine their dynamic response to various environmental inputs and to satisfy the indicated

ween two non-hazardous materials and is lightweight and small enough to be field-deployable, thus eliminating the concerns of conventio

lize on those discoveries and develop intensive culture methods for indoor grow-out in recirculation systems. The commercialization plan in

bility of our approach.

tion associated with the DMD device without sacrificing speed or resolution.

ension of integrity constraints for ontology developers and users of supply chain messaging validators.

continues to enable tracing of more animals, both in terms of size and economic quantity.

y slow rate while observing the conductance of the protein pore using a high frequency AC drive potential. This proposed system will allow

g the SiC nanowires grown in this project. This gas sensor will allow the detection of greenhouse gasses like Nitrous Oxide and CO2 with ex
mplete sensor cells will be fabricated and evaluated.
l prototype, and to install it at a NOAA tidal station.
are tools will be provided to easily manipulate the results for visual representation or for distillation into text-based parameters for risk ass

d assemble a breadboard instrument and use it to perform preliminary testing of new sensors; (5) develop specific recommendations for a
s based on newly available optical fibers. Our goal is the development of a spatially coherent SC source operable in the 4.5-12 µm spectral r
lization tools aimed at helping users diagnose performance issues and understand communication patterns between nodes.
llating MEMS fux concentrators, currently in development, which will allow greatly improved noise performance (~1 pT/rtHz) at low freque

ential to add more features tot the control hardware and software, which will broaden the automation from the narrow but critical functio
methods. Results will provide the basis for detailed prototype system design to be developed, deployed, and evaluated under a Phase II eff

t of an integrated microdevice will be evaluated.

on core technologies unique to PPC: advanced ion beam sputtered (IBS) thin-film coatings, nanometer-level surface metrology, and state-of
ng threat, and incorporating polarimetric radar data into the algorithm in anticipation of the NWS polarimetric upgrade.
 system will also be developed in Phase II, with a total instrument weight of 3 kg, including the CCR receiver and horn antenna. Two comple
her radar systems and AAMPS. This novel system takes advantage of recent technology advances in FPGAs, a network processors and com
tional- and time-scales to rapidly assess the impact of predicted climate change on natural fows at critical nodes along a river network
are difficult to detect using conventional smoke detectors and carbon monoxide monitors.
ping specimen enclosures for harsh environments permeates this simplistic yet highly innovate High Pressure Specimen Chamber
red thin film platform would enable the production of new, high performance pyroelectric detectors, power meters, energy meters, broadb
r to operate, is completely automated, and will greatly increase the accuracy and throughput of current protocols for alpha spectroscopy.

rovement in diver safety.

oveable asset on the farm, replacing poured concrete vessels for larger-diameter fiberglass pipe sections, which can be disassembled for m

strial chemicals, toxins and bacteria, and a field portable unit, incorporating the SERS library, will be produced and tested at an U.S. Environ

phyifos, and copper), whose toxic effects on C. dubia have been well-defined by conventional testing, will be used to generate expression si
of cellulosic biomass. Preliminary experimentation indicated that HED2 proteins act synergistically with cellulose in the hydrolysis of crysta

generated ClO2.
pability to conduct water monitoring for organic chemicals, toxins, and microorganisms in near real-time using economical instrumentation

ay, with current prices, to produce green propane, and will support more rapid exploitation of biodiesel as a component of the national en
ers.
hese boilers. Our TMC technology can be used to recover the water vapor and energy from this fue gas for boiler feed water makeup. Prio
or external sources of Mg and TiCl4. Because no separately produced Mg or TiCl4 is required, the environmental issues with producing Mg

offering the GPSS, and the firm would retain product stewardship for sustainability, such as product return for recycling. GPSS are expected
posite-wall units operated side-by-side under village field conditions. Ambient weather will be recorded via a Davis field weather station, an
or external sources of Mg and TiCl4. Because no separately produced Mg or TiCl4 is required, the environmental issues with producing Mg
pability to conduct water monitoring for organic chemicals, toxins, and microorganisms in near real-time using economical instrumentation
offering the GPSS, and the firm would retain product stewardship for sustainability, such as product return for recycling. GPSS are expected

(diazinon, chlorphyifos, and copper), whose toxic effects on C. dubia have been well-defined by conventional testing, will be used to gener

uction of cellulosic biomass. Preliminary experimentation indicated that HED2 proteins act synergistically with cellulose in the hydrolysis of

wall units operated side-by-side under village field conditions. Ambient weather will be recorded via a Davis field weather station, and burn

strial chemicals, toxins and bacteria, and a field portable unit, incorporating the SERS library, will be produced and tested at an U.S. Environ

ers.

oday, with current prices, to produce "green" propane, and will support more rapid exploitation of biodiesel as a component of the nationa
generated ClO2.
hese boilers. Our TMC technology can be used to recover the water vapor and energy from this fue gas for boiler feed water makeup. Prio
ovide additional fexibility for crew training and safety by connecting to the aircraft data bus. The Boeing Phantomworks vehicle health ma
h including power supply, motor, drive shaft, gears, couplings, pump, and valves. This proposed research project would develop and exten
om control and diagnostics to tamper protection, configuration status monitoring, and intrusion protection and configuration assurance. Th
cable constructions. The fibers will be a drop in replacement and compatible with MT and 29504 type connector.
perties: no thermal degradation up to 450 deg.C; very high tensile strength; excellent chemical stability; no hydrolysis problems even at elev

ops image processing algorithms, creates an electrical/software architecture concept for real-time operation, and examines ultra-high ban
hase 2, with the end goal of delivering a system that NIST can use in its cutting-edge atomic clock and quantum information processing exp

e visual feedback to pilots during landing in brownout or whiteout conditions. Areté Associates and Vescent Photonics have teamed to prov
nal band. Surface motion noise will be minimized by isolating the magnetometer from surface wave motion with a mid-water drogue desig
al system (CHAOS) being proposed here is based on the physics of optical augmentation (OA), occasionally referred to as the “cats eye” effe
m for micro-UAVs based on the innovative integration of contemporary bio-inspired technologies. Core design components will consist of a
the optimal thermal detection of buried IEDs.
Navigation Guidance Algorithms, and extensions of the Total FOR and IFOV beyond minimum threshold. Initial downselection is made in th

and discriminate targets from decoys. All of these applications require advances in the ladar technology to improve performance, reliability
the capability to conduct trade studies involving target acquisition performance, including the effects due to weather, countermeasures, an
mall UAV Class II platforms. The missions will be directed at retrieving water depths (other Very Shallow Water (VSW) and Surf Zone (SZ) pa
function (MTF) through a volume of water. The modulation transfer function (MTF) is a measure of how light is scattered and absorbed wh
ting electric dipole signatures in addition to the traditional magnetic dipole moment. These breakthroughs will open the possibility of littor
II and implemented in vetted algorithms.

aviors, and culturally significant objects. Key features of the proposed approach include: • Use of open standards, including COLLADA, X3D

plications as diverse as medical imaging contrast agents and electronic memory. Metal oxide or metal nanoparticles can be made of any tr

araView will provide the capability to view results and modify analysis parameters during a simulation run. This will enable analysts the cap
for complex data analysis in large-scale accelerator modeling. Phase I will determine the set of features required to create an effective coll
mate projections, the models must be based on high-quality greenhouse gas measurements made globally over decades. This project will d
of atmospheric gases, at very high data rates, over years of operation in remote locations. Three analyzers will be sent to independent rese

y of this prognostic paradigm can be demonstrated, the Phase I results can be used in a subsequent Phase II effort to refine the sensor desig
tate (modal), random or transient vibrations. This feature of the MXLDV is unparalleled by existing optical methods such as scanning laser D
beacon formation time. During Phase I, we will study the operational performance of the proposed methods. The results will facilitate det
ed and updated electronically. Since the spatial light modulators can be updated at video rates or faster, there is also the possibility of usin
d diagnostic will provide measurements not obtainable by current methods, and will enable experimental data that can be used for validati
ust methods while monitoring the vibrational characteristics of the manufacturing tools to identify sources of degradation.
at the image plane of a receiving telescope. During Phase I, we proved the concept, examined the performance of the proposed method an
ion method for reconstruction of the thermal history from a given sensor readout. Several sensor module considerations will be investigate
r test ranges. In Phase I, we demonstrated the feasibility of the scanning concept by building a breadboard scanner and simulating projecti
e an image of moving objects. In Phase 2, we will seek to improve the optical model and build a full-scale prototype using commercially av
feature of the MLV is unparalleled by existing optical methods, significantly exceeding their operational capabilities in terms of speed, resol
aperture precision metrology of such optical components. In Phase II we will deliver a complete turnkey instrument based on the Phase I re

focus on creating multiple voices by modifying voice types, gender, dialects (accents), and perceived emotion of the speech. Based on the
erform the entire process of voice transformation, including data collection from speakers, automatic training of the conversion functions f

vanced algorithms developed under this effort will be immediately tested on live data from the theater through DAC’s BOBCAT system – a t
M) algorithms to improve the ability to reacquire lost targets. Second, novel techniques are needed to improve track correlation and contin
and deployed in the near-term, while our work plan ensures that we remain forward-looking and plan for future development blocks.
dels. These technologies, combined with DAC’s experience in missile defense will result in algorithms suitable for simulated, end-to-end te
AMR computations in the area computational hydrodynamics, and the Cactus computational toolkit, which is an infrastructure package de
diverse sensor types as well as unanticipated sensor behavior in the face of increasingly difficult scenarios. Application of the proposed algo
d testing of candidate components for the ASoSC2 system as well as mathematicians and computer scientist with extensive experience in B
ty, resulting in an automated reasoning engine that integrates logical relations with probabilistic reasoning about complex, imprecise, and
ween planning and execution through application of a novel class of algorithms that are able to rapidly identify near-optimal allocation sche
nge, the DECISIVE ANALYTICS Corporation team is pursuing two related objectives. First, we are developing a framework, based on the Du

ddressed. This project proposes to develop an effective system of converting current depot shop foor paper-based work instructions into I
Air Logistic Centers (ALCs) across the United States. Some of the previously adopted initiatives that have added value by producing imme
er development. The product will deliver lessons in atomic behavior underlying real world physical and chemical phenomena.

an industrial fabricator.

sugar fermentation, as an alternative carbon source for denitrification in aquaculture systems. Through a series of lab-scale denitrification
tion (PECO). Several variables need to be evaluated and optimized before a commercial-scale device can be used to replace biological filtrati

hatchery space, labor, and water resources must be fully committed to channel catfish production throughout the peak of the channel catfi
exposures to air-borne toxicants can be determined from sounds produced by the colony. We will build a library of sonograms referenced t
to effectively alert the user about developing decay.

dard. The research also probes the effects of uptake enhancers and inhibitors on SFP availability, in anticipation of use of SFP as a dietary s

the supervision of the teacher. Additionally, the project will deliver a “video report” for parents that will provide a virtual simulation of the

ignificantly enhances the user¿s senseof safety, security, and independence by providing a means of sound recognition heretofore unavaila

hysical models and fractal models in combination with percolation theory. These approaches represent the major categories of research do
ted onIIenteric
Phase study. microbes to identify strain variants capable of rapidly fermenting hemicellulose syrups to fuels. These platform strains will b

ent. Such a low cost test would also have applications in monitoring the passage of the infection between wild and cultured shrimp. This Ph

ed and compared to the production time of traditional autogenous vaccines. The effectiveness and safety of the PRRSV ARP vaccine will be

pitalizing on two key features of this material, the relative inertness of the FEP inner surface and outer surface metalization, in the developm

n the hand-held physical model and the virtual software model to enable users to view changes in properties as they manipulate the molec
facilities. The BIN may be deployed in a variety of applications, ranging from residential communities to thoroughfares and major roads. C

r surfaces and does not allow the creation of scouringeffects at the base of protrudingvertical sensors.There is a demand by erosion resear
target in the most effective and efficient way. Previous work, based on computer simulations using the algorithm, predict supplemental lig

materials and approach that if corrected could enable additional applications in forestry research and identify areas of research where the s

ctual laboratory equipment. The lab experiments will be assignable and gradable electronically and will be designed to integrate with existi

proteins, induces DNA replication by the host. Rep protein can be expressed in trans, and it is capable of excising a pro-vector from chromo

ve already been produced and are highly effective but for different uses, a large array of pads and sheets with different properties are nece
 ls and other devices, most hydrogen is currently produced primarily from non-renewable sources, such as natural gas, oil, or coal.

is small,
vant lightweight
to induce sensorresponse
an immune will perform the desired functions of measuring the speed of passing vehicles. The wireless communication wi

e. We predict that increasing dEB 4 days prior to transport will cut in-transit losses in half. If the commercial feeding test is effective, subseq

crypted files. The back-end of the silo is AccessData s DNA distributed code-breaking software which uses distributed computing resources
es to interface with the Aculight source and to meet DHS goals.
be designed to be low cost, and mechanically and electronically robust, to ensure its wide distribution and use at ports throughout the wo
the many commercial applications of the distributed buoy detection system are as a &quot;persistent sonobuoy&quot; system for extend
hich the rescue spreader can be amenable to long term storage, safe handling by trained personnel during operation, safe handling by unt
s. The software s data capture and analysis routine feeds an alert messaging engine. When the software detects radiological sources, it sen

ed by this type of malware, but rather by the examination of operating system internal data structures for any corruption or inconsistency. T
ncentration system that rapidly separates both generic debris and bulk atmospheric gases from those samples of highest relevance, and qu

ractical and effective, will result in a surveillance system with the following benefits: 1) Ability to provide real-time localization of the radioa
net, a cost-effective, rapidly deployable, and reconfigurable wireless first responder monitoring solution to facilitate emergency personnel m

al of replacing pressurized 3He-tubes and current solid-state detectors with an ultra-compact detector based on CMOS-SSPM (Solid State P
easily penetrate dense, high atomic number materials compared to gamma rays. The goal of the proposed effort is to build next generation
n source will enhance the performance of a field emission design for a compact high fux neutron source previously developed by the Lawre
Successful completion of the Phase II effort will result in a compact, non-radioactive CNT ion source suitable for use in DMS and other analy
ltiple physical networks without compromising the security of the data. The technology will facilitate secure cross-domain collaborations fo

we will refine the modulation schemes, validate the modulation patterns on multiple test vehicles, and will develop hardware prototypes.
subsequent development for decryption of multiple common encryption container formats. It will also open the door to using multiple FPG
y Optima HLS used in the identification and response to simulated incidents. To this effect inexpensive COTS sensors will be used to mock fi
ely on an SE-Linux Operating System in order to secure the operating.SINBAD will be packaged as a preinstalled 1U to 2U network device a
everaging the FirstLight infrastructure, the generated signatures from iBEAR can be distributed globally across organizations.
able from a safe distance. Our innovation is a portable, lightweight, inexpensive device that can be readily deployed and remotely activate

at least one linac prototype will be developed and tested with a high-energy X-ray inspection system produced for cargo inspection operati
devices to move this technology to manufacturing readiness. Testing at LLNL will include electron microscopy to verify the effectiveness of
ers such as ECG, respiratory rate, CO exposure and body temperature; 2) sensor and health diagnostic anomaly detection capabilities to en
efficiency without sacrificing a simple cleaning method using brushing and self baking. The method of collection may employ either a defau
ounded and established data dimensionality reduction techniques. Development of efficient data classification and data fusion are two oth

Dr. Peng Ning from North Carolina State University propose a secure network access control system that ensures authorization of commun
r-based DTS is extremely robust and can be used in harsh environments. As a passive optical device, it does not require power, and is immu

ed by this type of malware, but rather by the examination of operating system internal data structures for any corruption or inconsistency. T
 n to the launch platform, will include wireless activated follow-up EMD capability, and will not be enabled until after the projectile has bee
evere constraints. The process is time and labor intensive, and it also lacks consistency of inspection. To address the issues of effective samp
The combined result is a wide sweep width with a high POD. Phase I will concentrate on proof-of-concept using a commercial microbolome
high levels of aggression. These situations meet the requirement that an additional lethal weapon must be trained on an individual or grou

ormatic sequence analysis to the chemical analysis domain, extending them as necessary to handle richer data sets. In a Phase II continuati
n initial prototype hand-held chemical detection system. In a continuing Phase II effort, we will validate an integrated detection system tha
then be easily registered by pulse counting electronics. A fast gamma scintillator provides timing verification of the neutron 10B/Gd reactio
nal pattern recognition engine. The anticipated benefits and potential commercial applications of the sensor array products include a new s

an 100X the frequency of existing betatrons, produces greater than 100X the current of existing betatrons, occupies (including power suppl
he signal is similar to the attenuation of radiation in an isotope gauge. The proposed device will not only replace isotope-based industrial g
ed V-TEST system is operationally safe, will require no consumables, and will draw less than 10 W of battery power. In Phase I POC will asse

e. Detection on several absorption lines (fingerprints) provides high selectivity against commonly encountered materials. The proposed sys
ting, to prove the concept. The HiProWSer is relatively simple, highly effective, reliable, and low cost. Because of its remote control capabil
. A system based on low power non-ionizing TD-THz measurements will be developed which can replace multiple types of nuclear source g

TICs to CWAs and explosives.

of packaging the Talon Biosensor in a portable handheld form factor and discriminating between ricin and SEB in multiplexed assays. System

hnology and field test units with local typical end users. This work will utilize our Frontliner"/Site command hardware and software as a sta
mmercial Application. Current network prevention, intrusion detection, and prevention applications tend to be single scope rather than int

ds of control systems and remote monitoring through wire and wireless technologies along with its university tie-ups TSi will address all the
vide both the ease of plug-and-play sensor installation and operation as well as a high level of security. This will be provided through the us
hat its technology can achieve measurement precision comparable to a NDG and statistically identical readings with a single soil class. The P
ketize biometrics data for global satellite communications connectivity, sufficient on-board data processing and storage to house a significa

time monitoring of background neutron fux.

equipped with the most appropriate sensor grouping for their job.

her first responders, and federal opportunities including DHS and others.
e location of possible tamper sites, as well as potential suspects, ISTs secure wrap technology will greatly improve supply chain security. Th
mocompatibility in clinical evaluation. This type of valve has the potential to address both the blood compatibility problem of mechanical va

cting magnet based MRI system. There are many reasons for wishing to perform small animal lung imaging in animal facilities rather than i
n of patient sequelae and co-morbidity. Improvement in adherence to standard prevention, treatment, and management practices is a reas

rected evolution of function, 2) by optimizing the design of the promoter-template construct for specific amplification needs and 3) by re-s
urpose of the proposed research is to create and test prototypes to identify issues that need to be addressed to develop a practical comme
 ng have demonstrated great promise for scalability as well as an improved quality of results over traditional representation techniques suc
thods have been developed that promise to provide much of the information in confidential micro data in a manner that permits much wid
ve array for volumetric imaging having extensive applications in the fields of radiology, obstetrics and gynecology. Beyond this near term m
cells. We need to identify compounds that inhibit death of photoreceptors or RPE cells so that dry AMD can finally be treated effectively. T
pounds directly. In vivo assessments of retinal toxicity, when performed, require large numbers of animals, are time-consuming and expens
al model will also be conducted. The outcome of this grant will be to identify the optimal stimulation parameters and implantable design fo
m Medicare data to NIA-supported surveys. The aim of this SBIR/STTR project is to expand MedRIC?s efforts to include data sets collected b
edicare data to NIA-supported surveys. The aim of this new SBIR/STTR is to extend this linkage of Medicare data to incorporate informatio
to nanoparticle surface. In this NIH SBIR project ADA Technologies Inc. will use our proprietary glycan surface conjugation chemistry to dev
rally diverse glycans. ADA proposes to develop aminooxy- and hydrazide-functionalized dendrimer monolayer films on solid substrates for c

and too much cable tension to effect grasp. These problems leave many children without an acceptable device at precisely the time they sh
tency and selectivity of compounds based on binding to recombinant human and rat adenosine receptor subtypes; 2) evaluating the perm
as been performed with increasing success. Despite these encouraging reports, several obstacles remain that prevent the widespread adop
n - toxin's activity. The specific aims of this Phase I study are: (1) Establish and validate assays for testing the ability of beta -CD derivatives
asures in a platform designed for quantitative assessment of neurocognitive functions including alertness, attention, learning and memory.
me and assessing titration levels in patients fitted with mandibular-advancing devices (MAD). The primary goals for Phase II will be to: 1) a
oluses or other agents, and placing the patient supine. Most of these countermeasures have a negative impact on the patient and the qua
rations of digital microfuidic manipulation of nanoliter-sized droplets of enzymatic reagents and sample for dispensing from on-chip reserv

ny days between using their computer. Consequently, the impact of personal computers on the self management of chronic problems is sta
d will create a larger market for the portable EEG recorder. Researchers conducting longitudinal EEG surveys will benefit by sharing a marke
ical exam in a relatively immobile patient population. At present, reevaluation frequently requires admission to a PICU or at a minimum, ev
clinical utility of a portable, low-cost quantitative thermography system to be used for serial imaging of a patient receiving spinal unloading
technically feasible at this time. Up to seven small wireless sensor packages may be worn on the body to collect motion and optionally oth
it will not suffer from these limitations since they will locally amplify, digitize, and transmit digital EMG signals without the need for wires,
ated inside a small, portable device. Such a device would be able to provide low-vision users with a valuable indoor low-cost way-finding to
AP) and local field potential (LFP) from freely behaving and seizing humans. It will also remove restrictions imposed on patient movement a
known as granulin precursor (GP88), is a novel and preclinically validated candidate of choice as it plays a critical role in breast cancer cell
g AKT signaling in cultured breast cancer cells and archival tissues. During Phase II, we will demonstrate its tissue applications with animal m
probed with a blood sample the array can identify the presence of tumor-associated antibodies in NSCLC but not in normals with both sen

level of 1RCA/3x10e10 viral particles, and such a manufacturing process cannot be claimed to be ?controlled? by FDA standards if the fai

ed efficacy without added toxicity when AdV-tk gene therapy is combined with radiation therapy. The current study proposed in this appli
well, School of Health and Environment, proposes to develop a fast response, compact, room temperature, dual quantum cascade laser bas
the ODP problem. New problems with formulations and device incompatibility made it time-consuming and expensive for the pharmaceuti
to eliminate the parasites and decrease the risk of them developing drug resistance. The main problem is cost. Malaria victims are usually a
way information from gene expression microarray experiments performed in-house. In order to take advantage of the much more diverse in
vation. To greatly improve this situation and directly respond to the need expressed in PA-06-028, this STTR application represents a joint e
s sleep, known to infuence cognition. Visual discrimination using a touchscreen method, frequently used in clinics, has been adapted recen
overcome any or all of these obstacles have great potential for improving treatment of many diseases including heart disease, diabetes, ca
care. Using phage display technology, Affinergy has identified a series of peptides that bind with high affinity to a number of metals, includ
mitations including immunogenicity, risk of disease transmission, limited availability, and high procurement costs. Many synthetic alternative
cells, which are the third and truly essential element to foster bone healing. A device that could isolate stem cells from a bone marrow asp
Using specific patented and tested algorithms the system will be able to give the user the following information on a monitored individual: 1
e proliferation and/or differentiation, and to bind and deliver growth factors. Expression of a heparan sulfate-decorated recombinant Perle
vations of this technology is the ability to deliver DNA, not protein, to generate natural, endogenous Perlecan expression in the wounds or s
cial learning pedagogies with distributed simulation technology. This combination is part of a new framework that we call Collective Simula
vice that will monitor the particulate matter in air and autonomously transport the data for analysis. In addition the device architecture wil
ice banking capability has already been used successfully by a number of ALS patients. This Phase II STTR application seeks funding to com

project will establish the feasibility of developing a lead drug candidate that is a peripherally-selective, long-acting neutral antagonist expec
It will: Integrate research data across distributed heterogeneous data sources, even data from legacy sources with poor interfaces and da
however the same principles can be utilized for other tissues. The proposed hydrogel- based tissue expander will utilize biodegradable cro
s. A competitive immunoassay is proposed to militate against detector antibody cross-reactivity in a sandwich immunoassay array format;
ms in Phase 1 are to develop and implement an internal standard for on-cartridge infuenza RNA sample preparation and detection; develo
nd accuracy of these intricate analyses. Our alternative to expensive, custom designed integrated culture systems is to provide low cost, sca
en speed and sensitivity. Imaging CCD arrays can evaluate all of the wells in a plate simultaneously, but have low sensitivity and limited tem
ued evaluation of the condition. Radiation Monitoring Devices proposes to develop a compact, disposable microfuidic sensor that will rapi
d a tradeoff between spatial resolution and efficiency significantly limit the performance of these powerful devices. To address these issue
which consist mostly of light elements. Neutron scattering experiments can resolve not only the atomic positions (elastic scattering) but al
sting hypoxia in a growing tumor can cause changes in the cells leading to aggressive cancer phenotype. Hypoxia driven progression often
ears of age or younger. Unfortunately, lead does find it's way into toys. In February 2006, a four year old boy died of lead poisoning after sw
veloped through nanotechnology that is capable of achieving virtually full transparency in ceramics of even optically anisotropic materials.
performance of current clinical PET systems is limited by the available detector technology and there is an urgent need for improvement in
o a modified architecture CCD with a specially designed readout to accommodate high frame rates. By the end of the Phase II research we
gradually expanding, particularly in the areas of detecting coronary artery disease (where it shows ~10 to 15% higher accuracy then SPECT
ties simultaneously. The most immediate benefit of the integrated system will be to provide high-resolution anatomical context for PET stu
propose to develop a large area digital imaging detector for thermal neutrons, which offers a better combination of surface coverage, spatia
nce like this. But the current state-of-the-art is not doing a great job of it. The reason is simple-current systems are focused on not making m

es, and biological cells. The development of this method will allow one to obtain quantitative results, increase the sensitivity of particle agg
etection procedures are slow, labor intensive and error prone. Because of the subjective nature of sample evaluation, results from these te
ntly success has been seen in a class of drugs that are neuroprotective in many neurodegenerative disease models, the cannabinoids. Intri
heters. First, coating constituents will be selected to maximize activity. Activity and mode of action will be characterized with a close look a
d with a cost between $750-5000 per procedure, the cost to the U.S. healthcare system is significant. Ultrasound is widely regarded as the
hich minimizes collateral radiation damage of healthy tissues. Based on microdosimetry studies on a-particle cytotoxicity, it appears that a-p
are published discussing the therapeutic effect achieved in current research. This grant application will increase the amount of these isoto
target pathogens and biomarkers. This system will provide significant advantages over current test methods that take many hours to sever
logies developed during Phase I which augment this approach include: i) solid-phase PCR to produce BS-LIVE-DNA from cDNA libraries, ii) a
ult to link specific mutations to individual viral species. The principal objective of this proposal is to develop a highly sensitive, cost-effective
cating mutations in the APC gene from fecal DNA as part of a large-scale population CRC screening test. Such mutations constitute the earl
Most inactivating mutations (>80%) are chain truncating and distributed throughout the gene. The preferred method to detect such mutati
e presence of biomarker signatures with disease diagnosis, prognosis, or staging. MicroRNAs comprise an exciting new class of small, regula
ukemia were reported in the US in 2005. Leukemia is the number one cause of deaths from cancer in children and young adults under age 2

to homogeneity. However, the preliminary structural data fails to establish the feasibility of conduction high resolution structural studies.
no voice messages are played; and an intervention phase, during which hand hygiene is recorded as before and voice messages are played
on with metoclopramide (a currently used but problematic treatment), and a study of how NO affects the physiological mechanisms of gast
ocyte growth factor, exerts direct hepatoprotective effects and can potentially be used as a therapeutic in ALF. However, the feasibility of u
ar modeling, phage display, rational drug design, targeted proteomics and in vitro biology, Angion Biomedica Corp. has identified two, chem
largely through its mitogenic and anti-apoptotic activities. Addition of recombinant SF/HGF to the preservation solution enhances post-tran
elial cells lining the tumor's blood supply. Antagonism of the c-Met-SF/HGF pathway is thus an attractive multi-faceted approach to targetin
ude, relieving or controlling symptoms. For example, corticosteroids and other immunosuppressive medications are being routinely emplo
underlie pathologic disorders. Tissue injury induces infammation, and infammation triggers angiogenesis, which in turn, initiates tissue re
ations are characteristically expensive and difficult to administer. Therefore, therapeutic approaches that employ small molecule mimetics o

818, 2001). With the help of the imaging technology, we have developed a unique tumor-targeting Salmonella typhimurium strain (Proc. Na
eful tool for drug development. This includes identifying culture methods for increasing HCVcc titer, developing HCVcc genotypes relevant t
major advantage is the rapidity with which each product can be generated and the generic nature of the process for many peptide and prot
he difference was both substantial (~100% dark adaptation impairment for AMD patients relative to normal old adults) and statistically sign
t has been demonstrated that PG normalizes keratinocyte growth in vitro. Psoriasis is characterized by abnormal keratinocyte growth, and
have shown that this compound has strong growth-inhibitory and apoptosis-inducing properties in hormone-sensitive and hormone- refrac
n by physicians and acceptance by patients. These desiderata include: Accuracy, Low cost, Convenience, Simplicity, and Familiarity. The Apn
cade of events that results in the vascular leakiness and neovascularization that are hallmark pathologies in eye disease. Therefore, SK is a
tment of T1D in the clinic. The main objective of this proposal is to establish proof-of-principle for a novel, safe, and practical approach des
ourse of tumor progression. These interactions are primarily regulated by two opposing forces; immune mechanisms that target the tumor
y deliver TAAs/TSAs to APCs. This vaccine formulation also activates APCs for the generation of an effective anti-tumor immune response w
ree main goals: (1) engineer APMS for maximum and selective uptake by human MM cells in vitro; (2) study the kinetics of uptake of shRN
ls grown in lipidic cubic phases. Thus, there is a critical need for more reliable and rapid methods fort the accurate characterization of cryst
edia Web based application is a more effective in training moderate sedation providers than current didactic lectures and seminars. Th
user, thus significantly increasing the situational awareness of the user. In addition, the display significantly increased the accuracy of the d
For Phase II, several aspects of the PkPd Display merit development and further evaluation prior to commercialization: 1. we will evaluate
ods for fuid force calculations on the valves and implement the coupling between the fuid and the valve; (2) implement computational tec
out increased bleeding risk. Human apyrase represents a highly promising therapy for acute ischemic stroke. We will utilize a clinically relev
mize the dose regimen of APT202 that will provide significant benefits while maintaining low bleeding risk in established animal transplanta
puter-analysis software to quantify and classify wing-beat signatures. This amazingly sensitive and rapidly responding novel sensor detects
rints for each compound. Microarrays in sheepshead minnows will round out EcoArray's offering of microarrays for environmentally signific
ways often alleviates symptoms such as dyspnea, cough, or hemoptysis. Endobronchial interventions provide rapid relief of symptoms, imp
teractive medical simulation environment which has the potential to visually convey complex information to patients to improve underst

uency. The goal of this project is to develop and commercialize a system for long term storage of precious liquids that eliminates or significa
satisfy these criteria. Being dependent on human experts, these data resources usually store a very limited amount of information about c
ng function. One key observation of P. aeruginosa infections in CF is that the infection fails to elicit opsonic/protective antibodies in patients
ystem that enables the enzyme to cross the BBB following intravenous administration. A new approach to the BBB delivery of large molecu
imit of detection and dynamic range. The ESP technology will provide a broad platform for many different kinds of assays. It is versatile, an
opment performed to date has advanced beyond the original objectives of Phase I. Three generations of the CFM-a prototypes were design
zation is observed in ischemic retinopathies such as diabetic retinopathy, retinopathy of prematurity, central vein occlusion and branch retin

we plan to develop a robotic system for biopsy and related needle procedures in mice, based on MR images. The robotic system will allow f
surement and acquiring a corresponding reference spectrum. Subsequent spectra will be referenced to this initial spectrum, and a novel pa
orter domains will be customized with specific protein-recognition molecules that detect the OP poisoned proteins. This will make it possib
al issues required to advance the application of MAPC based therapy to treat HI injury in neonates. This Phase II STTR submission has 4 spe
e of its excellent analgesic activity and long duration of action. Moreover, unlike morphine, respiratory depression is not usually a problem w

thereof. These probes anneal to the target DNA at each end of a sequence in the genome that contains only three of the four possible DNA
 reposition transducers several times during the test is counterproductive to the goal of reducing tester intervention. The poor ambient no
ze, that the loss of efficacy of these compounds leaves very few treatment options for patients with multi-drug resistant infections. Clearly
that delivers therapeutic doses to the inside of the eye for 3 years with a single implantation. The team of investigators is expert in polymer
ed in part through SBIR Phase 1 and 2 funding, the PI has developed sustained release formulations approved by the FDA for the treatment
posal were: to formulate sustained release suspensions for the dopaminergic agonist apomorphine; to test the in vitro release characteristic
portant role in the pathogenesis of pulmonary fibrosis. Studies have shown that antagonizing TGF-a appears to ameliorate lung fibrosis. The
nd sensitively bind Aa (the chief constituent of amyloid plaques). Working with our collaborators, we have recently demonstrated the safet
min.) means that C-DTBZ clinical studies are only feasible at a limited number of centers with on-site cyclotrons. Since the PET isotope F has
search into various methods of preparing allografts to enable them to be more viable clinical options. Nerve allografts have been studied in
IPN. There are currently no treatments. CIPN results in significant added morbidity for cancer patients and may require the clinician to redu
nd the attachment to fibronectin were shown to be necessary for BCG-mediated protection against bladder cancer in animal models. Strain
ore accurately guide treatment and management options, and therefore would improve patient outcome while reducing management cost
nstrating the accuracy of the new approach in predicting each of the conventional psychometric instrument scores via Bland- Altman analys
at a very early age. Assessment of the consequences of low birth weight, adverse pregnancies, or complicated births on the structure and
stical study of questionnaire item performance as it relates to the underlying respondent traits. All necessary tests of IRT assumptions, item

biological indicators of living microbial spores are the most accurate and reliable systems for sterility articles but the major disadvantage w

rt disk" engine that addresses limitations of existing accelerators. The proposed engine combines the fexibility of reconfigurable FPGA logic
s and functions as the CDCU /FCDCU Windows application. The target population is heavy drinking college students (5 or more drinks per o
nd actions; and to work towards long-term satisfactions and quality of life. It s protocol for change is based on motivational enhancement a
he United States Hispanic population: LosAngeles, Miami, Dallas and Boston. The 160 items developed in the Phase I study will be self adm
e initial aims of this Phase I proposal are to: 1) Determine content for the prototype utilizing an advisory board of BA experts; 2) Create the
Treatment; PCT). The proposed online training program will substantially aid in the vital training of community mental health clinicians and
use fuorescence based immunodetection of GDP to measure RGS-dependent increases in the steady state GTPase activity of modified Ga p
e chemical gradient. The project is a collaboration between Salus Discovery, a developer of microfuidic technology, and Dr. Anna Huttenloc
compartment tissue model in a highly parallel fashion. This means that potential drug molecules can be tested for their effects on disease p
rter HuES cell line with insertion of enhanced green fuorescent protein (EGFP) that is driven by promoter of neurogenin (Ngn) 3, a marker
nciple studies to show that the treatment agent is efficacious in reducing the size of primary as well as metastasized prostate cancer. In the

ngth than SC strength. Even larger increases in both SC and LC dynamic strength and muscle morphology are achieved by combining lower-
pharmacokinetics studies. Yet, pigs are under-utilized. A device that makes it easier to obtain their biofuids, and also simultaneously acquir

acterization of these enzymes has been reported to date. Based on our experience in the cloning, over-expressing, and characterizing new
measure the electric field in both benign and malignant human skin lesions and have found that malignant basal and squamous cell carcino
ing increasing patient comfort and decreased cost to patients and healthcare providers. The aim of this Phase I proposal is to engineer a co
atrixTM. LabmatrixTM will provide a software-based platform for the collection, manipulation and interrelation of molecular, genomic and
to identify patients susceptible to these drugs. Virtually all patients with EGFR activating mutations who clinically respond to the TKI, gefitin
ce of pWGA, including reaction time, product yield, as well as product quality in terms of amplification bias using a combination of single nu
n ultrafiltration application in life science research and compare this performance with published data on the performance of conventiona
able to PM analysis. One principal goal for this STTR project is to adapt PM technology for these fastidious aerobic, microaerophilic, and an
ermore National Labs, BIOMEC has developed prototype pneumothorax detection devices based on patented Micropower Impulse Radar (M
mic and anti-infammatory anti-selectin compound OC-229 developed by our laboratory, which blocks adhesion molecules such as P-, L-, an
pyrrolidone, Sucrose and Fibrinogen, with a water-soluble foam inducer; the addition of thrombin and P-selectin inmunoglobin chimera, an
the spatial or temporal dimension. BioMedware recently developed Space-Time Information Systems (STIS) technology, a time-enabled geo
elationships between health outcomes and potential factors, such as environmental and occupational exposures, socio-economic condition
and disease manifestation, and that use exposure windows of varying duration will be defined. Several of the methods so derived will be ap
dent and proven risk factor for eye damage in the short term and glaucoma progressions in the long term, which if left unchecked or unma
at value to be able to pre-sort them prior to further single molecule level analysis in nanofuidics. In order to help reach this objective, we p
nating both the need for chemical synthesis of peptide antigens as well as the chemical conjugation of peptide haptens to carrier immunog
ck sensitivity in early disease. There are a number of B. burgdorferi antigens recognized early in human infection such as FlaB, OspC, VlsE,
trated that, in the Lyme disease mouse model, ad libidum feeding induced systemic anti-OspA IgG and protected all vaccinated mice from B
provides the best means for early detection of kidney disease. The test that is most widely used in the US to screen abnormalities in GFR is
of cells with IVST materials, to demonstrate that all measurements can be performed with the newly developed IVST nano-particles and to
ast reagent that is ideally suited for MRA. The formulation of this reagent is based on a novel chemical procedure for the production of stab
ating that TL1A might play adversary roles in these diseases. TL1A is known to be mainly present as a soluble form but so far, there have be
era of patients with bacterial infections thus indicating that the protein might play an important role in the pathogenesis of bacterial infecti
successfully imaged. In order to immobilize patients for long acquisition times, retinal and anterior segment OCT imagers commercialized t
novel advanced technology platforms. We believe that the unique properties of BioScale's sensor system meet the rigorous needs of an H
nge-gene target in E. coli with varying lengths of synthetic DNA (5 to 32 kb) and to measure the efficiency of lsGG- mediated single- gene ta
ndetectable background signals. The signal is typically generated in one of three ways: a change in conformation of a fuorescence-quench
ns of DT can overcome the technical barrier to recording wideband brain signals from moving and seizing epileptic patients. In collaboratio
quirements because they already have lost the capability to speak or they cannot speak with adequate consistency of pronunciation. A new
and an invasion of this protective biofilm by lumen bacteria in IBD (dysbiosis). Our initial results indicate that there is little variation in this

ternet, to raise awareness and improve knowledge and attitudes about chronic diseases and their risk factors experienced by this target po
parcely soluble agents and e) delivery of surfactant. Using this bench model of SUPRAER we generated large aqueous aerosols which follow
terization, we have shown that "organism-pure" samples such as single colonies and clones can be identified in ca. 1.5 hours. The platform
ucose sensor which is one of the most promising long-term glucose-sensing technologies currently being pursued for application in diabete
goal of this Phase I SBIR grant application is develop a far-red fuorescent bi-functional caspase-3 substrate that can be used for multiplex d
seable data. This effectively doubles the price of each data point over what is ideally possible. In order for a planar patch clamp experiment
Smart Telescope is small and lightweight, but large enough for the elderly to handle and control; simple to operate and easy to carry, store
oulder arthroplasty. This will allow a surgeon to execute a patient-optimized plan more quickly and more accurately with fewer risks and co
polyethylene glycol moiety without significantly affecting the protein's in vitro bioactivity. In addition, pharmacokinetic studies were perfor
erapeutic intervention in RA patients. Our overall goals are to create a long acting VEGF inhibitor and test its efficacy in animal models of RA
A second goal will be to demonstrate diffraction-limited retinal imaging in human subjects possessing optical aberrations of the eye that en
h-ventilation, low-perfusion mismatch from PE on the composition of exhaled breaths. The central hypothesis states that the instantaneous
educe the incidence of infections and unnecessary illness, allow better use of health care resources, reduce healthcare costs, and save lives
enesis. This study proposes to develop a targeted antimicrobial therapy against Streptococcus mutans. By selectively killing or inhibiting th

, pharmacogenetics, and others to contribute to reducing the incidence of adverse treatment reactions, discovering diseases earlier, and op
ene Environment Initiative (GEI). We will measure exposure to metal stressors in biospecimens by developing BRES that can identify expos
lab space and 1800 square feet of office space. This area is well equipped for chemical and biological R&D. Equipment available for this w
re of the clinical disease. The overall goal of this project is to identify small molecule compounds that block or reverse SOD1-based protein
d neural cell lines that stably express a human DJ-1 promoter-directed luciferase reporter protein and have validated this cellular assay by i

point-of-care evaluation of this property. By monitoring a readily accessible body fuid, Cantimer proposes to provide a simple tool to the he

p was successful preparation of the most auspicious subset-so-called "side population" cells-from human myocardium, resembling but disti
peutics from biodegradable PLGA nanoparticles has been shown to be effective in increasing drug efficacy due to the ability to better delive
he development of algorithms that are able to quantify the optical signals and therefore derive absolute values of SctO2. More import
n, LLC (CARE) is committed to the dissemination of evidence-based practices in addiction prevention and treatment through educational se
HUCBC-infused PSAPP mice demonstrated increased A? phagocytic activity, thus clearly demonstrating HUCBC's potential immunomodulat
ogy. The research proposal is divided in to three specific aims employing human pancreas-derived cells; 1) Verification that the licensed cu
research project will utilize cDNA microarrays, proteomic profiling, and viability and functional analysis to define the stress response pathw
eatment of advanced stage prostate cancer. This Phase I project proposes to develop a novel therapeutic cryosurgical device (CryoInject(tm
otection of the neural vascular bundles (NVB) and ultimately erectile function during the cryosurgical treatment of prostate cancer. The rea
he method and its tools, using an immunoaffinity approach with an antibody specific for acetylated-lysine. We will first screen several acet

ring thousand of new phosphorylation sites in human cancers which must be processed and uploaded into PhosphoSite(r). We propose to
cal trial failures could reduce the average cost of drug development by nearly $100 million, not to mention saving people's lives in clinical t
for cell-based HTS of peptide drugs as an alternative to HTS of synthetic peptide or chemical small molecule libraries. The long-term goal o
ental platform to construct functionally validated (FV) shRNA libraries. Under Phase I funding, we initially propose to develop a FV human s
ious program funding, we have developed a novel experimental platform to identify functional shRNAs at a genome-wide scale. The ultima
immunomodulation of the gastrointestinal mucosa. These progenitors are well- characterized, short-lived, subpopulations collectively refer
sing animals. The fu virus purification columns, if successfully developed, will likely replace the continuous fow centrifugal system, which i
adjust drug therapy regimen. Similarly, HBV and HCV viral loads have also been used to monitor disease progression and treatment efficac
d typically multiple assays are employed. Human heart cells represent the ideal cell system for determination of cardiac toxicity, but adult h
pear to visually match those in a reference photograph, the medicine is considered to be verified. There are serious adverse consequences
miniaturization. However, Centice's unique spectroscopic engine, which decouples spectral resolution from optical throughput, offers a tec
ystal 2- D arrays utilizing a new photolithography based deep etching method. This method can not only provide lower impedance element
method to create composite piezoelectrics using single crystals. This PMN-PT material has a very high electromechanical coupling coefficie
e production of a number of second and third generation macrolide analogs, there is an astonishing lack of differentially-glycosylated analo
s derived from digitoxigenin have already been found with nanomolar potency and high selectivity in cancer cell cytotoxicity tests, revealing
tions to test the hypothesis that machine perfusion can improve the yield and viability of islets prepared from ischemic pancreases. To this
will provide all the conventional components of the Complete Blood Count (CBC) as well as a differential white blood cell count. An assessm
owever, no robotic anti-EA assay is commercially available. To begin to meet these governmental, scientific and commercial needs, CertiCh
cious, and marketable drugs for the treatment of DR. Combretastatin A4 (CA4) is a natural tubulin-binding molecule, which has received sp
hieved significant commercial milestones in the past 12 months. Charlesson recently added a founder of Atomic Venture Partners to its exe
ave displayed anti-angiogenic activities and have been used for the treatment of several infammatory diseases and cancer. The application
sis. Leptospiral infections can be treated with inexpensive antimicrobial agents. However, timely treatment is considered to be essential to
maller clinical or hospital labs by utilizing a rapid and inexpensive system based on robust, electronic detection technology. The proposed g
. We have constructed yeast gene- replacement strains depending for growth on either human ACC. Our research has already shown that g
exchange, activated alumina, and others. The goals for this Phase I program will be achieved through the following Specific Aims: 1) to func
omarkers will be consistently detected in human cervical secretion during pregnancy, and that quantitation of these candidate biomarkers w
d intelligent tutoring. Those lines of research are connected with emerging but currently manual methods for assessment and treatment, i
mune cell functional capacities. The technology allows for highly parallel measurements that result in the capability to perform hundreds of
ult in highly predictive and accurate assays. The holistic clinical picture obtained from this advanced protein molecular diagnostic approach
ng children and adolescents are unable to give large samples. The objective of this SBIR proposal is to develop an automated T cell analysis

e for most non-invasive brain monitoring across many neurological diseases, affecting some 50 million people of all ages every year, in the U
cal features and confirmation on neuropathology. Clinicopathologic studies have shown significant false- positive and false-negative diagno
to develop alternative pharmaceutical strategies that bypass the shielding of brain parenchyma and to study new therapeutic approaches
expertise in Internet technology, web usability, geriatrics, and health promotion to complete Phase II development of an innovative website
 d (1 R41 MH073197). Data from the evaluation of that first module are highly encouraging. Eighty-two percent of those recruited complete
ries with particular receptor selectivity, CNS penetration, and efficacy in animal models of schizophrenia and cognitive function will be eval
eposition is more often correlated with dementia in individuals afflicted with AD and CAA. Recently, we generated novel transgenic mice th
ment with different doses of COG112 using clinical outcome measures, histological outcome measures and measures of a panel of represen
on would provide a fundamental improvement over current treatments. Recent research indicates that infammation plays a significant role
s demonstrated to suppress activation of and reduce secretion of infammatory mediators. More recently, we have demonstrated that COG
E is the principal apolipoprotein in the CNS modulating lipid and cholesterol metabolism relevant to myelination; and 2) apoE may affect m
ental autoimmune encephalomyelitis (EAE) models of MS, even when administered after the onset of disease. We EXCEEDED our aims by i
orbable small bone adhesive which would satisfy the surgical need for a strong, resorbable adhesive to adhere small bone fragments durin
's proprietary biocompatible polyurethane tissue adhesive can be engineered into a sprayable formulation that will be effective in closure o
nous adjuvants, and cause the DCs to mature and migrate to the draining lymph node where they activate na ve T cells. The speed with wh
prehensive, structured auditory training for ESL learners. Thus training will be closely linked to the perceptual errors determined in pre-train

analysis the CMS system is seen as a platform technology. Significant opportunities exist in pharmaceutical solvent recovery enhancing che

These results warrant further investigation on mechanism of action and structure-activity relationship. The over-all objectives of this propo

out the need for a sound room or other audiological instrumentation. The protocol will be implemented in a prototype, computerized instru
st, will be obtained by employing the charged particle counting technique that is capable of a large dynamic range permitting sensitive dete
es vary by type of pain, ranging from 8% to 45% for low back pain (Girolamo, 1991) and from 2% to 50% for headaches (Stewart, Shechter, &
ftware will allow researchers and biotech business to simulate highly charged biomolecules upon readily available computers. Specific Aims
mpare wound stability as a function of intrachamber pressure in four in vitro models of clinical corneal surgery: radial keratotomy, LASIK fap
l is analyzed to calculate hemoglobin concentration. While our proof of concept studies on the accuracy of this technique used a commerc
Current mandibular distraction devices are used in combination with reconstruction plates, but while the reconstruction plates take the co

T with the full-length LL-FDI instrument (LLFDI-Fixed) from an existing database; and (3) evaluate scoring comparability, respondent burden
ransfers require major installation or permanent renovation. LifterMate is relatively inexpensive, easily maneuvered from room to room, ea
tient confusion and perceptions that information is meaningless for decision making. PickCare(tm) is a hospital comparison tool that will ad
storation of function of the affected limbs. We hypothesize that the FES component may improve both efficacy and availability of TRS4000

nhaled nitric oxide can combine with hemoglobin to form nitrosyl- hemoglobin, which is rapidly oxidized to methemoglobin. In the treatme

(tm)) technology platform for high-throughput cell imaging and in situ laser-mediated cell manipulation has been used to develop the Cell

ates the load-bearing properties of the native tissue by combining adult human stem cells with a biomaterial scaffold made by a new three
efit for immunotherapy, and there is accordingly a need to find as many such molecules as possible to obtain the best candidates for therap
n to provide evidence and rationale for the development in Phase II of commercial products as novel therapeutic strategies to alleviate acut
ersons with risk factors for vascular disease. In these studies described in this Phase I proposal we will perform cell sorting and functional s
ray crystallography or by standard NMR spectroscopy indicate that the vast majority of proteins will simply fail to result in appropriate samp
ucation Act (IDEA) mandates transition planning during high school; however, staff often lack the resources, training, and tools needed to e
s, visual aids, and evaluation forms; 2) A participant workbook that reiterates key concepts, provides visuals that reinforce content, and incl
ed psychiatric disorders. People with TTM often feel shame, poor self-esteem, and feel and become isolated from others. Because of the la
milies most in need will not be able to make use of increasingly available effective treatments (Zahner, Pawelkiewicz, DeFrancesco, & Adno

earch-based approaches into a replicable, manualized psychoeducational program that can be easily integrated into existing treatment cent
 , investigator has to adjust the heterogeneity within a cluster of observations or between clusters. Overdispersion is also very common in s

mild symptoms of CF must follow a 3-hour treatment regimen every day, and medical experts report that their adherence ranges from poo
gned for family members affected by BPD. Our hypothesis is that family members who view the Living with Borderline Personality Disorder
he curriculum in the classroom. Evidence strongly supports implementing alcohol prevention curricula in middle school, in particular, preve
lity and develop/validate protocols for pharmacokinetic studies. Upon completion of these studies a Phase II application will be submitted

mal and informal caregivers. Evaluate the final product with a large and diverse population. INNOVATION: Translation research of existing re
n to smaller geographic units, than ever before. Over 50,000 townships with approximately 1,500 unique data items will be delivered in a ge
em that overcomes the clinical difficulties encountered with current visualization systems and (2) the fabrication of instruments for improve
on, special risks to minors and the risks of fetal alcohol exposure have emerged increasingly in the alcohol research literature but remain in
believe they have an ethical obligation to participate in eating disorder secondary prevention, lack of knowledge of oral and physical mani
hen testing them against chloroquine-sensitive and chloroquine-resistant malaria in red cell culture (an in vitro test), as well as for solubility
a's health, retirement, and other age-related characteristics, using a methodology that protects HRS respondent identity. Following an asse
val (PMA) by the Food and Drug Administration (FDA). The pre-clinical studies will be based on FDA's "Review criteria for assessment of HB
A patent for DCP has been issued to Differential Proteomics Inc. The goal for a subsequent Phase II study is to apply DCP, newly optim
are used to purify the difference proteins, which are then identified using mass spectrometry. DCP will provide a fast, cost-effective process
hrough this study. Phase II of this project will entail the development of an interactive component for patients and providers. A link will be c
rios on the design of SPIMA and collect 150 voice samples from 30 subjects. The voice algorithms will be tested for reliability on these dive
ymatic activity, but when co-expressed they can combine to produce an active 2-gal that generates a highly amplified luminescent readout
sing from EA. Alone, EA is inactive, but in vitro it can spontaneously recombine with ProLabel to form an active enzyme that can catalyze th
of multiple diseases using a 'universal' non-viral vector system whose properties will be applicable to many therapeutic transgenes. The Sp
nto host cell chromosomal sequence. In Phase I studies, DGI demonstrated the successful loading of transposon DNA and RNA into cultured

e-induced hearing loss. Phase 1 of this project involved integrating communication capabilities into the doseBusters hardware. Phase 2 of t
elective pressure of mass treatment has lead to recent signs of parasite drug resistance. Similar challenges face the campaigns to reduce o
e during scanning of tissue and cell specimens. As a result, the array microscope can rapidly and continually reconfigure itself during imagin
equence similarity and evolutionary relatedness. Hybridization, however, is governed by sequence dependent thermodynamics, NOT by seq
lor distribution in three dimensions. We intend to develop this into a marketable product, by addressing the following Specific Aims: A. Fur
er than the gain in going from 4.7 T (200 MHz) to 11.7 T (500 MHz) ? and at a small fraction of the cost. In addition, these gains will be achi
gious and successful researchers in macromolecule structure determination by solids NMR methods have voiced the need for major increa
rial environments. Priorities will focus on providing instrument fexibility using existing equipment to upgrade NMR sample preparation me
olycrystalline mercuric iodide for direct conversion of incident x-rays into charge, coupled to a CMOS readout structure for charge readout. D
he use of these current-mode detectors results in generally poorer image quality than could be achieved by using the technology proposed

MMPF method to the assessment of dynamic autoregulation using the instantaneous BP-BFV phase relationships during supine resting cond
ed for complex natural product production and the vector system used for high-throughput environmental DNA antibiotic screening will be
machinable materials. It cannot machine many important materials such as ferrous alloys, stainless steel, titanium and nickel due to catastr
ntly, because of the significant association between early infant development and childhood obesity and in light of the phenomenal increa
wounds receive appropriate treatment sooner, allow healing to resume, relieve their pain and discomfort, and avoid the spread of infectio

activated by binding of an analyte such as a mycotoxin. The long-term commercial objective of this project is to develop quantitative myco
erapeutic doses of antibiotics or anti-infammatory agents over a sustained period of time is difficult and there are major clinical problems
turation to refold this disulfide-rich protein in its normal biologically active form. While biologically active human SLPI has been successfull
eronin as a stable partially folded intermediate that can be concentrated and immobilized. In this trapped form, the captured folding interm
d purpose of using the strategy, detailed descriptions of each steps, video clips of students using the strategy in real testing situations, prac
uated. This program is a collaboration between Electronic Bio Sciences LLC (EBS), pioneers in the development of new ultra low noise electr
, current systems cannot achieve a low enough noise level to measure many channels with low conductances, such as the Ca channels. Sec
h Accelerators" or "SciPacs(tm)") or five clusters of four experiments related to a single science concept (Sci4Pacs(tm)). The SciPac(tm) prod
ls is limited. In this program, the SERS sensors would be worn as badges to monitor and quantify daily pesticide exposure to a worker by irr
ers (e.g., antibody/antigen complex) with the immobilized MRAs. The array would then be "read out" by a novel development and optical

our plans by one such major company, Medis (see letter from Medis). Assessment of viability is crucial in the monitoring of myocardial infa
phase II, we will evaluate the system in a more rigorous manner, applying it to the study of a larger population of children with special nee
boratory cultivation of microbes to be tested for desired activities, and soil microbes have been one particularly rich source of "druggable"
n to gold standards will be tested in a clinical study involving 95 normotensive subjects as well as dialysis and kidney transplant patients.
sed project and the product being tested for feasibility will produce a tool that changes the focus of applying research to practice from the
place because the resources and expertise necessary to collect the data and do the analysis are not available on a local level. What is need
ls who cannot use their biological voices to communicate easily with family, friends and their community, and instead rely on using an AAC
ally specific and quantitative multi-channel optical assay device for intraoperative assessment of tumor margins in patients undergoing bre
these agents. An easy-to-apply, safer, and more effective agent would increase use and broaden applications. The goal of this project is to d
ting incomplete obliteration of most aneurysms. Attempts to enhance the performance of metallic coils have hitherto shown limited succe
hnology using an electrodeless, inductively coupled plasma to produce light in the soft x-ray range. The Energetiq light source can be used t

ogy for use in a portable air sampler, we will integrate the aerosol concentrator with a capillary aerosol particle collector, and we will interfa
fic Aims of the Phase II program will include design and construction of a prototype field-portable analytical system for detection of arseni

ontroller will allow visitors to navigate through the model of the brain in 3-dimensional space, viewing brain structures from any angle. View
nfectious agents; 2) Production of murine monoclonal Rh serologic reagents with promise for specificity superior to those currently in use;

l in children as well as adults. APD can display resistance changes in real time, and can be modified to measure resistance of ventilated pati
is to establish germline competent rbES cell lines for the production of gene targeted transgenic rabbits. In Phase I we propose to prepare
nti-thrombotic therapeutic approach for the treatment of acute MI, especially as adjunctive therapy to current standard-of- care fibrinolytic
satisfied by murine hybridomas. Successful extension to recombinant antibodies will allow the recovery of human derived antibodies again
A specialized polymer delivery system has been identified that allows therapeutic plasmids to be formulated to very high concentrations (u
n, but also promotes the growth of human lacrimal cells, stimulates expression of MUC16, a protective mucin, by corneal epithelium, binds
any splice variant within the proteome. Once the proteome is denatured and digested, each individual isoform generates a unique signatur
inexpensive means of creating anti-CD4+ "avidity" capture reagents. This assay will be capable of being performed in resource-poor enviro
ivo study. Before the start of the performance period, we will make the final epitope selections. In the course of the SBIR award period, sel
n, the root cause of FVIII therapy failure, is a process dependent on antigen presenting cell signaling to helper T cells. We thus propose to d
stem can not only separate chiral molecules in milliseconds, but also reduce method development time to minutes. Great separation speed
aled breath condensate (EBC) collected using active breath management as alternative matrices for real-time, point-of-use measurement o
t", storing the information for later analysis, and notifying, in real-time by wireless or other communications, a healthcare provider if medic
imetaspheres, TMS) provide a platform for developing superior new MRI contrast agents. Our overall hypothesis is that these atheroscleroti
the reagents for two prototype cell-based kinase assays for monitoring activity of the proto-oncogene, Akt2. These prototype assays will b
le mature adipocytes can be isolated from human adipose tissue, 2) these cells can de-differentiate (delipidate) into fibroblast-like cells tha

ccur in the blood of obese subjects with non-alcoholic steatohepatitis, and [2] FAS derived from tumor cell lines is phosphorylated on threo
d mutants can be easily reverse engineered to reveal the identity of the strain improvement mutation they harbor in their genome. Once th
rs strain improvement has been performed by a random mutate-and-screen process that has not generated any information regarding the
(FABP). The specific aims of Phase II are to (1) confirm the accuracy of the Phase I UCB probe in neonatal plasma using blood samples from
 hat they do not progress through the normal healing phases. Instead, it is thought that diabetic wounds are caught and remain trapped in
evelop chemistry that makes DNA assays better"), this will create a platform technology that meets specifications that are unavailable at th
acute respiratory infections, lung cancer, and chronic respiratory and cardiovascular diseases, the specific biological mechanisms involved a

seline of system accuracy. Phase I will involve five tasks: (1) Sehda will define the scope of the interactions the system will enable by getti
el system, our team will demonstrate quantitative tracking of collagen expression in the chondrocytes, chondrocyte proliferation, and the s
us tag at either N- or C-terminus will be developed. The utility of fuorous-based peptide microarrays in enzyme and protein-peptide bindin
ch cell's response. Three important and widely used applications that our system can uniquely address are: (1) drug safety testing via hERG
h the SSP and ESSP assessments and practice resources were put online and pilot-tested in schools. Three major areas of further developme
visit is required for the physician to manually verify IOP control by tonometry. We propose to create an implant capable of both sensing IOP
s proprietary technology, Random Homozygous Gene Perturbation (RHGP), to discover novel host cell targets that enable cells to become re
uch as the heart and lung, and the time required for certain scanning procedures where the patients must hold their breath. To take full ad
oposal, it should be noted that though the aging population is clearly an important demographic for which androgen therapy may be indica
hat blocks all 3 transporters would be a very efficacious and possibly, a faster-acting antidepressant. This work is made possible by our synth
r current and future attacks. In Phase I of this program we developed prototypes that demonstrated how the integration of advanced intrus
est the AMM theory on submarine-like shapes. In addition, we propose to conduct finite element studies of AMM microstructures, in orde
e for the penetrator to perform high accuracy analyses of penetration events.
ration for use in the AN/AQS-20 Minehunter. Following development and validation of the Toolkit, MSI will design a candidate Forward Loo
co-operation with the Department of Mechanical and Astronautical Engineering at the Naval Postgraduate School in Monterey, CA. This te
that match (or correlate) the received signal with the list of signal signature templates (ideally such algorithms would migrate to the RFSQ
propriate waveforms and then reduce them to simplified loading functions that produce the equivalent structural responses. We will use t
nge to compensate for increasing free space loss over the duration of an interceptor fy-out. Welkin Sciences also proposes to design the Ad
nd demonstrate all critical components of identity-based security and in-band multicast rekeying into a network testbed. In addition, defin

ence contrast model, and a conceptual framework for the user interface. As part of our efforts, we will conduct a series of field experiment

provide SOCOM with a small, robust, compact, and power-efficient platform for performing remote, persistent surveillance.
articipating networks. An approach is included to optimally select inter-networking routers and routing protocols as a function of MANET c
algorithms for weapon control systems and associated weapon employment functionality need to be developed in languages such as the A
re the surface temperature at that point. The combination of that sensor and the one proposed for development under this SBIR program

and that it need to be adaptable as well as extendable to new threats as they emerge. We shall produce a SELF verses OTHER approach to i

networked using mesh routing protocols to increase the area of surveillance and further reduce power consumption and communication f
ctronics-based system using distributed controls to create a scaleable and robust, plug-and-play, tactical power distribution system.
snippet is sent to security personnel for verification, eliminating the need for costly camera systems. Additionally the system will use acous

e drawn. A master test plan (MTP) and test methodology will be prepared to assure adequate exercise of the preliminary design. The testi

r a larger, more capable, higher thrust system in the 10 kg class and do a preliminary design on the larger system by the end of Phase I.
k ignition, making it a true bipropellant system, eliminates these problems at the expense of greater system complexity. Since a very small
the machine. Applied individually, or in synergistic combinations, the aim is to achieve a reduction in windage power loss of at least a fact
rm and platform software executing on a target radio system. Initially, the tool suite targets the Joint Tactical Radio System (JTRS) Software
velopment effort and further support these goals. Third, once the vehicle is fying, it will be able to collect real-world systems operability a
ine their advantages. Additionally, it can overcome sun-light readability problem, which is a major challenge for all outdoors display system
adily communicated artifacts and (c) a common modeling hub that supports the integration of heterogeneous simulation and modeling tec
e to represent the properties of critical system aspects and provide tailored analysis and visualization capabilities to meet system stakeholde
nd provides tools that enable required analyses to be performed efficiently. These improvements result in significant development and life
y 12 inch in length cylinder or smaller package, and is comprised of the hyperspectral camera, processing engine, and mass storage device.
the integration of various software applications on the multiple platforms. The results of this study will be a basis on further development o
affic and analysis modeling, SATCOM resource and link analysis modeling, SATCOM performance assessment modeling, and OPNET simulati
"lidar equation." If in the field it becomes impractical to observe with the sun behind the observer, the lidar beam can also supplant meas
unmanned aerial vehicles. The miniature dropsondes will be preloaded into one or more ALE chambers and automatically activate upon rel
solutions and together as a total end-to-end solution. The results of this study will be used to produce final recommendations and serve as
has initially looked at some of the above areas, they have not yet been evaluated in conjunction with each other, optimized or even tested
roach will bring consistently reliable sub-meter dynamic positioning and attitude, high-data rate throughput in excess of ten (10) hertz, and
solution platform and architecture, a field-testable prototype system is achievable by the end of the Phase I. This Phase I effort will culmina
magery; to verify the model through a quantitative comparison of predicted and observed signatures of natural phenomena; to design alg
and a high energy density cathode.

y study for the concept design for micro-actuated optics which has the capability of 80x80 degree scan angles, with 5X optical zoom and w
s of nonlinear aerodynamic and nonlinear structural effects on each free-play and LCO responses from a 3D system perspective. Computed
n adopting the vortex confinement method. A generalized ROM-ROM procedure will be developed to combine the nonlinear structural mo
5) the error from support beam bending should be simply removed, (6) the error from different sensor heights should be eliminated, (7) the
ensor to be prototyped in Phase II. A feature of the effort is that feasibility will be supported by original terahertz spectroscopic measurem

ks can be used in applications such as Non-Line of Sight (NLOS) which requires very high power during firing the missile.
h fell short of the goal of 9 feet, but was well within the threshold of 15 feet. During Phase II of the project, AMT will continue to grow and
fer mapping for use by the FPA production houses. To this end, ARI has teamed with BAE, Raytheon Vision Systems, Teledyne Imaging Sen
s with outstanding dexterity and durability. Phase II will continue refining the work on the superinsulating fexible glove and will provide de

variations, subthreshold leakage, radiation effects, and reliability monitor. Design portability will be investigated for digital/analog full cust
de: (a) High-Speed Operation of the PLADAR, (b) Automated Source Polarization Control for the PLADAR, (c) Development of Optimization T
d for controlling other coating removal methods.
in efficiency over currently available heaters will benefit the user by requiring the transport of less liquid fuel.

program involves development of tailored hydrogenation and integration schemes targeting passivation of the defects, i.e. traps, responsib

dies to date that there is a variability in the vestibular sensitivity among individuals. Our device and methods lead to a direct assessment o

ed to wearer comfort. This new socket provides ultimate fit for improvement in the performance of the prosthesis. The socket adapts itse

ake place to optimize performance and demonstrate efficacy. This technology is inexpensive and readily applicable to the civilian population

expanded to focus on device design refinement, manufacturing technology, and performance evaluations. As a result of the Phase II prog
tive DNA aptamers developed using our proprietary technology for DNA aptamer production.

e will have a pre-production version of our product ready for immediate deployment in selected applications.
tion to result in a complete system for hearing protection and communication that provides hearing protection beyond the bone conduction
er develop our proposed concept, perform conceptual design, complete and refine the system architecture, and prove our preliminary conc
utgassing will also be demonstrated. Infoscitex is uniquely positioned to insert candidate bonded samples into ongoing radiation resistant c
better understand the information shown in an image.
e key for the hardware (RF) implementation of the algorithm for persistent and staring-mode airborne radar. Each individual subaperture d
rgistic composite conductors and set the stage for electrical systems to be integrated into a larger demonstration article in the Phase II prog
 g and demonstration will be performed during the basic Phase I effort to assist in the tradeoff analysis and option formulation.

e next level where they will interact with one another as well as the new modules planned in the Phase II workscope, in a seamless manne
oops while executing day to day missions. Infoscitex has established a distinguished team to address this problem, and have developed an
t come into contact with the sensed liquid. These factors ensure that our system is robust, with operational parameters that withstand mu
demonstrate the efficacy and superiority of IST’s LCATC.
-G straining maneuver (AGSM) can provide more protection than even a G-suit, there is no formal training metric. We will use our aerome
perature resistance to erosion by abrasive particles, demonstrating the feasibility of the approach. In Phase II, we will refine the coating mo
ystems into a representative sensor platform prototype for evaluation purposes. This will require continued collaboration with Bluefin Rob
er to best position our sensors for market entry.
ent(s) and structural/institutional drivers of stability. The interdisciplinary methodology is differentiated from the US Army Human Terrain S
the anode from chemical reaction with the cathode reactant. Polymer(s) or ceramic/glass electrolytes will be the choice for the solid state
vability after a simulated attack. Qualified DoD platform vendors, coating materials and solar cell arrays will be active participants in both t
addresses the most important issues when using a non-helmet mounted HMD/NVG by adapting a component of a system that has been su
hermoelectric or other solid state technology, but also use that power most efficiently by minimizing the power drop through the channels
sized format. The constituent materials are inexpensive. Hence, the proposed technology, at the proper manufacturing scale will provide m
hanical and thermal stimulation) and bone healing. We also propose to evaluate the GI toxicity of the test NSAIDs in the above in vivo mod

ability of the fake while maximizing fill factor and dissemination yield. Then, the Candidate Flake will be demonstrated at a scale of at leas
tts of net output power. A laboratory test of a thermoelectric device heated by a solid oxide fuel cell is also discussed. A conceptual design
gacy group in the Obscurants research community; as well as IIMAK, a global leader in the manufacturing and development of printing, im

noparticle doping as well as compensated by the geometry of the PhC via increasing the number of degrees of symmetry in the lattice. Adv
Management (EHM) system. IAC has teamed with GasTOPS for development of this system. The results and systems developed on this SBIR
leic acid preparation method consumes few watts for biomaterial collection (from air or liquid) onto the microstructured arrays and plasma
gh-throughput, compute-intense environment. In this proposal, Intelligent Automation Corporation (IAC) outlines a plan to address this criti
eld confines the plasmoid propellant and the external vacuum magnetic field insulates the thruster wall. The thruster can be operated with
n, and dynamic range among other key factors. Unique coupled cavity designs exploit intracavity enhancement without significantly limitin
bout 2.5 W. Unit size, weight and power are major design considerations to achieve user acceptability in a helmet mount configuration.
ecisions. Due to cost and hazards of direct tests with WMD materials, the research will include fusion of data and sensors information from
ed to configure and monitor the results.
costs and future proofing of hardware through fully portable software code. The Hyper64, first in a family of HyperX based chip products,
ommercial power supplies to provide a prototype solution that can be transitioned to production in Phase III. Demonstration weld repairs w

simulation tool for modeling the impact, penetration, debris generation and motion, and sympathetic effects such as component failure, fu
e tin oxide surface. Vista Engineering, working with a Hybrid Plastics’ patented formulation will test a group of the POSS derivatives and ap

oriented architecture with a common mesh infrastructure that facilitates rapid development of analysis model geometry. It integrates geom
sing an F-18 generator as the test platform.
l and (b) test a hypothesis about the functional form that a component’s degradation signal will follow, in the absence of a database of deg

ual information with the detection results; evaluating the ability of our integrated detection solution to approach the detection performan
ovided the means to optimally design inertial igniters for almost any gun-fired munitions environment, while achieving designs that are sign

chnical contributions to the standard community. This Phase II will fully develop all the software managers and simulation platforms for per
importance. In the Small Business Innovation Research (SBIR) Phase I Contract W81XWH-08-C-0014, Eigent conducted a technology feasibi

antages of rotary percussive drilling to solve the problems currently being encountered with the state of the art coring approaches. BENEF
eable battery; and (4) a platform system consisting of a robotically-modified High Mobility Multi-Wheeled Vehicle (HMMWV). The proof-of

r than the designed altitude. This will maintain the ground sampling distance and noise performance of the Phase III system, but with 1/4 t
nputs and to satisfy the indicated safety and activation requirements. The proposed miniature electrically initiated inertial igniters will be m

nating the concerns of conventional CO2 sources. The CO2 generator is capable of producing CO2 at a fow rate of 200 mL/minute over a 12

ms. The commercialization plan included in this Phase II project will integrate intensive and extensive methods and present a cohesive train

This proposed system will allow the current system noise and rapid polymer translocation rate limitations to be overcome to allow for a pr

e Nitrous Oxide and CO2 with extremely high sensitivity.

xt-based parameters for risk assessment.

specific recommendations for a high-temperature instrument up to 600°C; and (6) demonstrate capabilities by measuring oxidation in a na
erable in the 4.5-12 µm spectral region with an output power exceeding 100 mW in a band at least 800 cm-1 wide and a minimum power p
s between nodes.
mance (~1 pT/rtHz) at low frequencies.

m the narrow but critical function of rotation to include environmental and crop monitoring. This latter feature will have commercial poten
nd evaluated under a Phase II effort.

surface metrology, and state-of-the-art adhesive-free contacting.

etric upgrade.
r and horn antenna. Two complete compact-SFMR instruments will be delivered to NOAA, one for deployment on a small UAV, and a secon
s, a network processors and communication schemes and utilizes a unique system architecture to realize a solution that leap frogs over tod
nodes along a river network

ure Specimen Chamber

er meters, energy meters, broadband radiometers, custom OEM detectors, and multi-element imaging sensors.
otocols for alpha spectroscopy.

which can be disassembled for maintenance and/or relocation on the farm or resale. Due to the modular nature of the equipment, the sca

ed and tested at an U.S. Environmental Protection Agency (EPA) defined site.

e used to generate expression signatures using a 10,000-element spotted cDNA array developed in previous work. Each of these chemicals
lulose in the hydrolysis of crystalline cellulose. Expansyn Technologies objective for Phase I will focus on producing gram-scale levels of rec

sing economical instrumentation that can be operated in an unattended fashion. The anticipated commercial applications for this water mo

a component of the national energy balance The Phase I technology is clearly technically feasible and economically viable. It. is anticipated

r boiler feed water makeup. Prior to the Phase I submission, our pilot testing of the proposed TMC demonstrated the technical feasibility fo
mental issues with producing Mg and TiCl4 are eliminated. The new one-step processing that does not require external feeds of Mg and TiC

for recycling. GPSS are expected to significantly improve sustainability by closing the materials loop, and encouraging design for the enviro
a a Davis field weather station, and burnbox temperatures will be measured via high temperature monitoring probes and a hand-held laser
mental issues with producing Mg and TiCl4 are eliminated. The new one-step processing that does not require external feeds of Mg and TiC
sing economical instrumentation that can be operated in an unattended fashion. The anticipated commercial applications for this water mo
for recycling. GPSS are expected to significantly improve sustainability by closing the materials loop, and encouraging design for the enviro

nal testing, will be used to generate expression signatures using a 10,000-element spotted cDNA array developed in previous work. Each of

with cellulose in the hydrolysis of crystalline cellulose. Expansyn Technologies&rsquo; objective for Phase I will focus on producing gram-sca

s field weather station, and burnbox temperatures will be measured via high temperature monitoring probes and a hand-held laser unit as

ed and tested at an U.S. Environmental Protection Agency (EPA) defined site.

el as a component of the national energy balance The Phase I technology is clearly technically feasible and economically viable. It. is anticip

r boiler feed water makeup. Prior to the Phase I submission, our pilot testing of the proposed TMC demonstrated the technical feasibility fo
hantomworks vehicle health management systems (VHMS) group has agreed to be our mentor our engineers by providing aircraft domain
roject would develop and extend this technology in two ways. First, we would integrate our current phenomenological approach with a ph
and configuration assurance. The procedures and algorithms for security situation awareness will be embodied in the “Business Rules”. Th

hydrolysis problems even at elevated temperatures; no known arc tracking problems; extrudes well therefore low cost; Phase 1 results sho

on, and examines ultra-high bandwidth attitude control actuators required for precision airframe control consistent with the accurate angle
tum information processing experiments.

t Photonics have teamed to provide a state-of-the-art dust penetrating laser radar (DUSPEN) technology to see-through brownout/whiteou
n with a mid-water drogue designed to attenuate mid-frequency surface wave motion, and further mitigated by correlation analysis referen
referred to as the “cats eye” effect, and leverages existing Areté program activities in the area Afocal beam steering. Although the physics
sign components will consist of a stereoscopic vision system, an insect-inspired visual processing architecture, an adaptable neural-inspired

nitial downselection is made in the technical proposal. A 40º total Field of Regard and an Instantaneous Field of View of 8º is set as a minim

improve performance, reliability, cost, size, weight and power. In this program, Areté Associates will develop an adaptive multi-waveform la
to weather, countermeasures, and battlefield obscurants and clutter. Performance measures such as the signal-to-noise ratio, maximum de
ater (VSW) and Surf Zone (SZ) parameters can follow subsequently) by using time series imaging of shoaling waves.
ght is scattered and absorbed while propagating through an optical system. The scattering and attenuation coefficients will be directly calcu
will open the possibility of littoral ASW missions carried out by small, highly maneuverable platforms such as the Fire Scout against moder

andards, including COLLADA, X3D, and H-Anim. • Highly detailed virtual human models capable of multi-lingual speech with lip-sync, facial

oparticles can be made of any transition metal, actinide or lanthanide which can also be doped with metals from Groups I and II, and they

This will enable analysts the capability to interactively manipulate simulations. ParaView’s remote visualization capabilities will also allow
quired to create an effective collaborative system and will demonstrate a functional two-person collaborative visualization environment. Co
over decades. This project will develop a new greenhouse gas analyzer capable of recording CO2, CH4, and H2O mixing ratio of outside am
will be sent to independent researchers as part of three performance and validation studies. One analyzer will be retained for long term so

I effort to refine the sensor design and develop remaining life models. Such a complete solution for sensing and prognostics would enable
methods such as scanning laser Doppler vibrometry (SLDV), electronic speckle pattern interferometry (ESPI) or shearography, which have al
ods. The results will facilitate determining the optimal parameters of beacon formation on a scattering surface target for a laser beam propa
ere is also the possibility of using the SLMs to correct for changes in the background. In addition, we will incorporate state of the art electr
data that can be used for validating computer models for rocket engine performance predictions.
s of degradation.
ance of the proposed method and experimentally demonstrated the ability of this to concentrate a laser beam on the selected area of a ta
considerations will be investigated in detail, including sensitivity of crystallization kinetics to moisture in the environment, module assembly
scanner and simulating projectile movement, and identified the components needed for a high-speed system. In Phase II, we will build a p
prototype using commercially available lenses, sensors, and Galvo motors. The proposed camera will be especially suited for scanning focu
pabilities in terms of speed, resolution and sensitivity. The program effort will also focus on implementation of a comprehensive method wh
strument based on the Phase I research. The instrument incorporates an extremely robust, reliable, and accurate wavefront sensor for pre

tion of the speech. Based on the source-filter models, we will investigate algorithms for modifying source and filter characteristics, from wh
ing of the conversion functions for vocal tract and glottal source, and eventually real-time voice transformation. The RVTS is a hardware sys

ough DAC’s BOBCAT system – a tool that is on the GSA schedule and in the hands of the Warfighter performing predictive analysis on Iraq d
ove track correlation and continuity once new sensor observations are provided. The DECISIVE ANALYTICS Corporation will leverage their e
uture development blocks.
ble for simulated, end-to-end testing in Phase II, and integration and deployment to the BMDS via Phase III of this SBIR. The work outlined
h is an infrastructure package developed by Louisiana State University that provides a "plug-and-play" framework for cross-institution and c
Application of the proposed algorithms has been shown to produce fewer mis-associations and better run-time performance than other a
st with extensive experience in Bayesian modeling and reasoning. In addition, Decisive Analytics has a long history of transitioning SBIR te
about complex, imprecise, and uncertain situations. The proposed hybrid inference engine will moreover be capable of hypothesizing new
tify near-optimal allocation schemes while remaining completely decoupled from their objective functions. By defining the defense plan’s
g a framework, based on the Dual Node Network technical architecture that will allow the deployment of an interlaced information fusion

er-based work instructions into ISA-95 standard-based XML files configured for data loading ISA-95 compliant shop foor automation system
added value by producing immediate results, such as reduction in turnaround time and maintenance cost, include Lean Transformations an
mical phenomena.

eries of lab-scale denitrification bioreactor studies, the denitrification capabilities of PHA were quantified at more than 2.0 kg/m3-day usin
used to replace biological filtration in closed-system aquaculture. Phase 1 experiments will optimize PECO reaction kinetics by evaluating t

out the peak of the channel catfish spawn, we can not produce large quantities of hybrids during this time frame. Therefore, our objective i
brary of sonograms referenced to healthy colonies, as well as mite and disease infected colonies. We will develop statistical algorithms for

ation of use of SFP as a dietary supplement for individuals with high, unmet Fe needs. In addition, the data will shed new light on mechani

rovide a virtual simulation of the child’s performance on each screen of the assessment. This project will partner Children’s Progress with p

d recognition heretofore unavailableto these individuals. Moreover, the personal devices provide a convenient and powerful tool formobile

e major categories of research done in the literature to estimate soil WRC indirectly. In Phase I we anticipate determining the best image an
els. These platform strains will be ideally suited for industrial programs aimed at economically converting the currently underutilized hemic

wild and cultured shrimp. This Phase II SBIR will focus on completing the development and field evaluation of a cost effective prototype rap

of the PRRSV ARP vaccine will be determined via comparison to currently available vaccines for PRRS including modified live vaccine (MLV)

ace metalization, in the development of an improved and commercially viable air sampling device. Product development and evaluation go

es as they manipulate the molecular model in their hands.

oroughfares and major roads. Common applications include road-widening projects (allowing replacement of existing overhead lines by n

re is a demand by erosion researchers for an inexpensive sensor of these attributes.Feasibility of this device can be accomplished through t
orithm, predict supplemental lighting cost can be reduced by approximately half in cold and cloudy regions such as upstate NY. The project

tify areas of research where the system should not be applied. Phase II will implement prioritized recommended enhancements and demon

e designed to integrate with existing web-based grade-management systems. Testing of the prototype will be conducted with college-level

xcising a pro-vector from chromosomal DNA and inducing its replication. By integrating a pro-vector harboring a desired mutant locus into

ith different properties are necessary. These will be developed in this project. This research is expected to provide a major market for agric
natural gas, oil, or coal.

The wireless communication within the system will be based on the wireless protocol used in the VehicleSense street parking information

l feeding test is effective, subsequent work will focus on development of a water soluble cation-rich electrolyte that can be administered in

distributed computing resources to attack these difficult encryption problems. Technology does not currently exist to interconnect silo netw

use at ports throughout the world. Unlike penning diode sources the generator is expected to have a long lifetime. The project has a high
obuoy&quot; system for extended surveillance of both friendly and unfriendly waters off foreign shores, as a perimeter protection system
operation, safe handling by untrained personnel when not in operation, and safe transportation in both ground and air vehicles.
etects radiological sources, it sends alert messages using a variety of open protocols. Under the proposed Phase 1 project, V-RADS will be u

ny corruption or inconsistency. This more fexible approach will allow the identification of a much wider class of rootkits than previously att
ples of highest relevance, and quickly consolidates these collected samples for real-time analysis by any commercial trace explosive detecti

al-time localization of the radioactive sources in a laboratory with a spatial resolution of a few centimeters; 2) Ability to simultaneously rej
facilitate emergency personnel monitoring, tracking, and resource coordination. With this grant, we will create a feasibility plan for the follo

ed on CMOS-SSPM (Solid State Photomultipliers) technology. This technology provides a low-power, portable unit that can be mass-produc
effort is to build next generation neutron detectors for SNM monitoring.
eviously developed by the Lawrence Berkeley National Laboratory. The anticipated higher performance relative to existing generators will c
e for use in DMS and other analytical instruments, lowering their cost of ownership. At the end of Phase II, a complete working prototype D
e cross-domain collaborations for both synchronous (e.g. audio/video conference, chat) and asynchronous (e.g. document sharing, email)

ll develop hardware prototypes. Functional Phase II systems will allow us to demonstrate the technology to user groups (law enforcement)
en the door to using multiple FPGAs in parallel to achieve even greater performance gains.
S sensors will be used to mock fire, collision, and explosion events in a subterranean tunnel and show how first responder response time c
alled 1U to 2U network device allowing it to easily be connected to a network, configured and made operational. Essential SINBAD capabili
oss organizations.
deployed and remotely activated by groundbased personnel or from helicopters. Our innovation does rely on stopping the vehicle by comp

uced for cargo inspection operations: the Rapiscan Eagle System.

py to verify the effectiveness of the coating and thermal neutron conversion efficiency measurements to test the quality of the deposited m
maly detection capabilities to ensure accurate, reliable assessment of first responders physiological status and overall health condition; 3) c
ction may employ either a default collection trap supplied with the unit or use adaptors to fit any porous collection traps commonly emplo
tion and data fusion are two other important components in the proposed effort. We propose to develop a Maximal Entropy (ME)-based d

nsures authorization of communications and automatic key management among micro-electronic-mechanical sensors that are deployed in
s not require power, and is immune to electromagnetic interference, EMI. DTS is cost-effective and easy to install, and can quickly identify a

ny corruption or inconsistency. This more fexible approach will allow the identification of a much wider class of rootkits than previously att
until after the projectile has been launched. These features will ensure user safety before, during, and after firing and will allow for adminis
dress the issues of effective sampling Lynntech proposes to develop a highly efficient portable sampling system that will allow captured exp
sing a commercial microbolometer array and image analysis software. A prototype WAIRI will then be constructed and tested in phase II. P
trained on an individual or group before a non-lethal weapon can be used. This rule is common to domestic law enforcement groups.

data sets. In a Phase II continuation, we will develop a full beta version of the software and analyze data from several different technologies
integrated detection system that incorporates the new sensors and drift-correction features into a next-generation prototype using simple,
n of the neutron 10B/Gd reaction. The gamma detector also operates as an independent gamma detector with energy resolution capabiliti
or array products include a new set of design and fabrication parameters of sensitive and robust chemiresistor sensing materials for detecti

occupies (including power supplies) ~70 ft3, and will facilitate integration with current interrogation systems. In Phase I, we will implement
place isotope-based industrial gauging devices that consume ~50 kg of isotopes annually, but will have significant advantages such as the c
y power. In Phase I POC will assemble a proof-of-concept prototype and test it on surrogates. In Phase II we will develop a prototype for lab

ered materials. The proposed system offers real-time, reliable detection of multiple solid or liquid explosive contaminants in variable enviro
use of its remote control capability, it could be designed for use on UAVs. The system can thus be employed not only by the Coast Guard, A
ultiple types of nuclear source gauges in all of these applications. A time of fight THz measurement system will have similar or superior ca

SEB in multiplexed assays. System sensitivity is at 10pM for immunoassays and 10fM for DNA assays with 95% detection confidence, false p

d hardware and software as a starting point for adaptation to the needs of this specific application. We will commercialize the technology th
o be single scope rather than integrated. DMnet represents a convergence technology that will integrate security operations into a single s

ity tie-ups TSi will address all the necessary challenges in an aggressive work plan.
s will be provided through the use of the IEEE 802.15.4 standard operating in the 915 MHz ISM band as well as cognitive radio capability at
ngs with a single soil class. The Phase II objective is to demonstrate that it can be used with other soils and be a replacement for the NDG.
g and storage to house a significant on-board biometric database for realtime query, and a robust communications protocol to reliably utiliz

mprove supply chain security. This will be an invaluable tool for ensuring the safety of cargo coming into the country or going out to our for
tibility problem of mechanical valves and the durability problem of bioprostheses. The changes necessary for adapting the AbioCor trileafe

g in animal facilities rather than in MRI facilities. There are quarantine issues associated with not wanting to take animals out and bring the
management practices is a reasonable and worthwhile objective. The Academic Edge, Inc. (AEI) is developing a suite of educational mater

mplification needs and 3) by re-standardization of cDNA synthesis for lower RNA inputs. The combined improvements are expected to lowe
ed to develop a practical commercial device. The prototypes will be tested to insure that 1) its dimensions fit a wide variety of ultralight wh
al representation techniques such as fingerprints. These techniques include novel ways of graph matching, the organization of graphs in a h
a manner that permits much wider dissemination and use of the protected data. This project is a Phase I feasibility study of applying these
cology. Beyond this near term market, lies the potential to combine efficient 2D electrostrictive arrays with the commercially viable and low
n finally be treated effectively. The use of rodent models has a good track record for evaluating compounds against light-induced stress. Ho
are time-consuming and expensive, and do not provide data on toxicity progression. The ability to prepare stable primary mixed retinal cul
meters and implantable design for future clinical trials after the Phase 2. This project is intended to benefit those that have lost hearing thro
s to include data sets collected by the U.S. Census. In partnership with the U.S. Census Bureau, this STTR project will develop a strategy for
e data to incorporate information from two addition CMS data sources: (i) Medicaid enrollment and claims files, and (ii) the Minimum Data
ace conjugation chemistry to develop a simple and versatile method for one-step, site-specific conjugation of unmodified carbohydrates an
yer films on solid substrates for covalent, site-specific immobilization of unmodified carbohydrate probes. Miniaturized microwave radiation

vice at precisely the time they should be learning lifelong prosthetics usage skills. In Phase I, ADA demonstrated the technical feasibility of
ubtypes; 2) evaluating the permeability of lead compounds in MDR-MDCK cells as a screen of blood-brain barrier permeability; 3) assessin
hat prevent the widespread adoption of the application, including: The high level of skill required by those involved in the donor cell isolati
he ability of beta -CD derivatives to block the pore formed by C. perfringens epsilon -toxin and to inhibit its cytotoxic activity. (2) Test blockin
attention, learning and memory. The AMP employs a multivariate approach, combining EEG, neuropsychological tests and validated self-re
goals for Phase II will be to: 1) acquire a large database of ARES treatment outcome studies from 100 patients treated with MAD, 2) docum
pact on the patient and the quality of the dialysis. In this proposal we will evaluate whether an impedance threshold device (ITD), a novel
or dispensing from on-chip reservoirs, high speed transport, mixing, splitting and dilution, and absorbance, fuorescence, and luminescence

ement of chronic problems is starting to plateau. Fortunately, we are on the verge of a technical revolution in personal computing that shou
s will benefit by sharing a market with ambulatory epilepsy monitoring because of reduced production costs. Alzheimer's disease (AD) is an
on to a PICU or at a minimum, evaluation in an outpatient setting wherein patients are exposed to a wide array of infectious pathogens. Giv
atient receiving spinal unloading therapy. The phase II goal is to apply this approach as a novel and affordable outcome analysis tool. Low b
collect motion and optionally other physiological parameters such as heart rate, respiration rate, and blood oxygen concentration. The acce
nals without the need for wires, which is of particular importance in dynamic EMG measurements where the subject is in motion. Recent a
e indoor low-cost way-finding tool analogous to a Global Positioning System (GPS) device used outdoors. About 3.7 million Americans are v
mposed on patient movement and susceptibilities to artifact from movement caused by a tethered system. Ultra-wideband (UWB) is a fast
critical role in breast cancer cell biology, exemplified by the following: 1) GP88 is an autocrine growth/survival factor for breast cancer cells
tissue applications with animal models, and with human breast tissue sections from clinical trials in breast cancer patients treated with gro
but not in normals with both sensitivity and a specificity exceeding 90% at early and later stages of the disease. As used to measure tumor-

olled? by FDA standards if the failure rate is greater than ~ 10%. PER.C6 cells use a specifically designed matched vector to eliminate seque

rent study proposed in this application seeks to evaluate the combination of AdV-tk + prodrug gene therapy in combination with radiation t
dual quantum cascade laser based system for the quantitative analysis of multiple species in human breath by infrared absorption. In the
d expensive for the pharmaceutical industry to begin to use the new propellant HFA-134a. The new MDIs that use HFA-134a are 3-5 times
ost. Malaria victims are usually among the poorest members of the global community, and artemether is not inexpensive to make by curre
age of the much more diverse information contained in public microarray data, this proposal tests the feasibility of new methods to combi
R application represents a joint effort from Pennsylvania State University (PSU) and Afasci, Inc., to develop a novel noninvasive automatic sl
n clinics, has been adapted recently for mouse cognition assessment in Dr. Rothblat's laboratory (the co-PI). However, no standardized and
uding heart disease, diabetes, cancer, and Parkinson's disease, to name but a few. Affinergy has developed a generalized approach for
ity to a number of metals, including titanium and stainless steel. These metal-binding peptides will serve as the basis for engineering an an
costs. Many synthetic alternatives have been developed, but they are generally not as effective as the natural materials due to the absence
m cells from a bone marrow aspirate (BMA) at point of care would be of significant clinical benefit. In this phase I proposal, we will identify
tion on a monitored individual: 1. Ambulation Assessment and Fall Prevention - the system will be able to determine an individual's baselin
 te-decorated recombinant Perlecan D1 (rD1) in a variety of cell types has since been validated. The rD1 was shown to bind fibroblast growt
an expression in the wounds or surgical sites. With this patented technology, a host-glycosylated Perlecan core will be generated in vivo, int
ork that we call Collective Simulations. This framework will create extraordinary immersive, yet cost effective, learning experiences based o
ition the device architecture will allow easy extensibility to add additional sensors, measurement schemes and access requirements. The m
application seeks funding to complete transfer of the ModelTalker and InvTool technology from the research laboratory in which it was deve

g-acting neutral antagonist expected to block the unwanted peripherally mediated opioid side effects while preserving analgesic actions. Sp
rces with poor interfaces and data documentation. Automate exchange of information with other systems in the healthcare and clinical re
der will utilize biodegradable cross-linkers to delay swelling for 2-3 weeks so that surrounding tissues may heal from implantation prior to e
wich immunoassay array format; the sandwich immunoassay is reserved as a contingency to achieve the Phase 1 milestones. The decision lo
reparation and detection; develop a sample preparation sub-circuit for viral RNA isolation and purification; and assess infuenza sample pre
ystems is to provide low cost, scalable fuidics for perfusion culture using hydraulic/pneumatic technology and computer control. ALA Scien
ve low sensitivity and limited temporal resolution. PMT based detector systems have high sensitivity and fast temporal response, but can o
microfuidic sensor that will rapidly detect a panel of multiple TBI biomarkers from a blood sample. To accomplish this, we will integrate sili
l devices. To address these issues, we propose to develop a novel semiconductor scintillator that promises to produce as much as a three-f
ositions (elastic scattering) but also their dynamics (inelastic scattering). Due to the huge difference in scattering cross-section of hydrogen a
ypoxia driven progression often leads to local invasive growth, perifocal tumor cell spreading and distant cell tumor spreading. Similarly res
oy died of lead poisoning after swallowing a piece of a toy containing lead. This tragedy has resulted in a recall of nearly one million similar
n optically anisotropic materials. The technique involves the consolidation of nanopowders under conditions that limit the ultimate grain si
urgent need for improvement in PET instrumentation in order to exploit the full potential of this promising technique. The goal of the prop
end of the Phase II research we will have developed a fully functional prototype microCT system based on this novel detector. The envisio
15% higher accuracy then SPECT) and assessing myocardial viability. Recent developments in combining nuclear medicine with X-ray CT im
n anatomical context for PET studies. This will lead to better overall understanding of the origin of the PET signals. The 'in-register' MR imag
ation of surface coverage, spatial resolution, detection efficiency and dynamic range than is currently possible. The detector is based on a
ms are focused on not making mistakes which means that they miss a lot of opportunities to find facts. The best reported performance is a

ase the sensitivity of particle agglutination assays for detection of anti-HIV antibodies, and reduce time of analysis without compromising t
evaluation, results from these tests are far from uniform. In recent years, alternatives to manual test tube methods have been developed. S
e models, the cannabinoids. Intriguingly, this class of drugs, and specifically cannabidiol (CBD), also has anticonvulsant (withdrawal) and anx
characterized with a close look at covalently tethered versus physically bound peptides. As a part of this process, structural and functional r
sound is widely regarded as the adjunct (secondary) procedure of choice to mammography, especially for distinguishing cystic from solid m
e cytotoxicity, it appears that a-particles must traverse the cell nucleus to be effective in causing cell death. Designing a biological targeting
rease the amount of these isotopes by processing and purifying actinium-227, an isotope used in the production of neutron generators pro
ds that take many hours to several days to provide results, and typically only yield information about single pathogens. As an analytical inst
VE-DNA from cDNA libraries, ii) a method (PC-PRINT) to rapidly phototransfer the protein on each bead in the BS-LIVE-PRO onto discrete sp
p a highly sensitive, cost-effective and high throughput system for detecting drug-resistant strains of the HIV-1 virus based on mass spectrom
ch mutations constitute the earliest molecular event in CRC tumorigenesis. During Phase I, a new method based on mass spectrometry of i
ed method to detect such mutations is the protein truncation test (PTT). However, because of the many limitations of conventional PTT, it i
exciting new class of small, regulatory biomolecules. Data to date suggests that as many as half of all genes may be regulated by miRNA. Ov
en and young adults under age 20. Although myeloid malignancies have been traditionally classified by their morphological and cytogeneti

h resolution structural studies. We hypothesize that the challenges confronting structural analysis can be overcome through the developm
e and voice messages are played. "Hand hygiene compliance" is defined here as the number of soap and alcohol gel uses per patient day. W
hysiological mechanisms of gastric emptying. Successful completion of the specific aims of the proposal will definitively determine the feas
ALF. However, the feasibility of using this growth factor in the form of gene or protein therapy is compounded by numerous logistical issues
 a Corp. has identified two, chemically distinct, small molecules that activate the SF/HGF receptor c-Met. These drug candidates activate th
ation solution enhances post-transplant organ function. While administration of SF/HGF as protein therapy has potential for the treatment
ulti-faceted approach to targeting the tumor cell that also may reduce the risk of therapy-induced resistance by blocking multiple events in
ations are being routinely employed, but have demonstrated only marginal efficacy. Hence there is a critical need for effective but affordabl
which in turn, initiates tissue repair and tissue growth. Persistent angiogenesis is critical both to maintaining the chronic architectural chan
mploy small molecule mimetics of natural growth and protective factors may be powerful alternatives to such therapies. The primary focus

ella typhimurium strain (Proc. Natl. Acad. Sci USA 102, 755-760, 2005). This strain is an auxotrophic but fully virulent variant of the facultati
ping HCVcc genotypes relevant to the dominant drug development target, and facilitating drug cross-resistance studies by generating muta
ocess for many peptide and protein products, facilitating scale-up. Additionally, the three peptide products have their own inherent comm
old adults) and statistically significant (t = 6.02; p < 0.0001). Diagnostic sensitivity and specificity were 88% and 100%, respectively, with th
ormal keratinocyte growth, and evidence points to a breakdown in the glycerol- AQP3-PLD2-PG signaling module. Direct application of PG
e-sensitive and hormone- refractory prostate cancer cells. In vitro assays have clearly shown its effectiveness, even when compared to 1,25
mplicity, and Familiarity. The Apneos SleepCorder(TM) is a revolutionary medical device in that it (1) is the first method of SRBD diagnosis to
n eye disease. Therefore, SK is a key molecular target for the development of new therapeutic agents. Because of the pivotal role of SK in re
safe, and practical approach designated as ApoFasL to induce transplantation tolerance to xenogeneic pancreatic islets as a therapeutic int
echanisms that target the tumor for destruction and tumor-mediated counter-mechanisms that enable the tumor to evade the immune sys
anti-tumor immune response with therapeutic efficacy. This novel, proprietary molecule consists of 4-1BBL chimeric with core streptavidin
y the kinetics of uptake of shRNA constructs into APMS; and (3) use shRNA-loaded APMS to block ERK1/2 and ERK5 pathways. Assuming th
accurate characterization of crystalline materials. To provide a solution to this problem, research conducted during Phase I of this project de
tic lectures and seminars. This Phase I application contains four specific aims that will demonstrate the efficacy of the Web based traini
increased the accuracy of the diagnosis while reducing cognitive workload. Our research plan is to build upon the successful results in pha
ercialization: 1. we will evaluate the usability of the PkPd Display and ensure it will not interfere with other critical aspects of anesthetic de
2) implement computational techniques to further improve adaptivity, user friendliness and CPU turn around times; and (3) validate the re
e. We will utilize a clinically relevant embolic model to validate whether the protein provides significant neuroprotective effect without incr
n established animal transplantation models. The ultimate goal is to advance APT202 into clinic to improve patient outcome in terms of ox
responding novel sensor detects minute changes in light intensity that wings and other moving body parts of nearby fying insects cause to
rrays for environmentally significant aquatic species. Measurement and analysis of environmental contaminants is very important to the EP
de rapid relief of symptoms, improved quality of life, and may indirectly prolong survival by allowing patients to undergo chemo and/or rad
n to patients to improve understanding of surgical procedures. In Phase I, ArchieMD will use this environment as a basis for developing

quids that eliminates or significantly reduces all of these problems. This system stores liquids in standardized containers with machine-read
d amount of information about certain aspects of the mechanisms and toxicity of well-studied drugs. The bulk of biological, pharmacologica
protective antibodies in patients. This ineffective immune response allows the organism to escape elimination by acquired host immune de
he BBB delivery of large molecules such as enzymes is the molecular Trojan horse technology. A bi-functional fusion protein is produced w
kinds of assays. It is versatile, and has the potential to be used in basic biomedical research, as well as high- throughput discovery and clini
e CFM-a prototypes were designed, built, and validated in phantom testing by experienced endoscopists. The objectives of Phase II of this
al vein occlusion and branch retinal vein occlusion. The inhibition of vessel proliferation is the strategy utilized by current market technolog

s. The robotic system will allow for targeting of the anatomy from our small animal MR scanner, and will include a specialized mouse holde
s initial spectrum, and a novel pattern classification algorithm will be used to detect hypoglycemic events. Both in vitro and in vivo experim
proteins. This will make it possible to develop an inexpensive, yet highly rapid, sensitive, and accurate device to analyze exposure to OP pe
ase II STTR submission has 4 specific aims, which will complete the pre-clinical report package required for IND submission. Aim 1: Determi
ression is not usually a problem with this opioid. However, to provide adequate analgesia, repeated parenteral administration is required fo

ly three of the four possible DNA bases. Polymerase is used to extend one of the probes across this void region so that the complemen
 ervention. The poor ambient noise exclusion requires that testing be performed in expensive sound rooms. The inter-subject variability inc
drug resistant infections. Clearly, there is an immediate unmet need for new antibiotics with novel modes of action. Moreover, the overall m
nvestigators is expert in polymer chemistry, pharmacokinetics, drug development, and clinical otology. We have experience in all aspects o
ved by the FDA for the treatment of CMV retinitis, and for uveitis. We have also developed an intraocular delivery formulation for cyclospor
the in vitro release characteristics of these formulations into buffer; and to test the in vivo pharmacokinetics and the duration of the formu
rs to ameliorate lung fibrosis. Therefore TGF-a antagonists may serve as important therapeutic agents for pulmonary fibrosis. We recently d
recently demonstrated the safety and biodistribution of this radiopharmaceutical in an initial Phase I clinical trial. In other ongoing clinical
ons. Since the PET isotope F has a 110 min. half life and has a well 18 established nationwide distribution network, an F version of DTBZ wo
e allografts have been studied in small animal models (e.g. rat) for grafts ranging in length from 1 to 4cm. A large animal model would allow
may require the clinician to reduce or even stop the dosing of the anti-cancer medications, potentially reducing their effectiveness in killing
r cancer in animal models. Strains that carry a recombinant constitutive FapB expression cassette will be verified genotypically and phenot
while reducing management costs. Banyan Biomarkers Inc. has been recognized as a pioneer in the development of ultra-sensitive brain inju
t scores via Bland- Altman analysis (and corresponding statistical tests for zero bias, equal standard deviations, and significant R2 values) ba
ated births on the structure and function of an infant's central nervous system (CNS) and its development is important for ob- taining valid
ry tests of IRT assumptions, item calibrations, assessments of model fit, and differential item functioning will be performed. The MIRT anal

es but the major disadvantage with these indicators is that seemingly sterilized articles must be stored for prolonged times to ensure sterili

ility of reconfigurable FPGA logic, which can be reprogrammed at will and easily upgraded while running at hardware speeds, with an inno
students (5 or more drinks per occasion for males, 4 or more for females & peak BACs >80mg% in the previous 2 weeks). Phase II goals inc
on motivational enhancement and cognitive-behavioral principles and strategies. The four point program focuses on: 1) building and main
he Phase I study will be self administered to the adolescents along with the criterion measures and analysis will determine the standardize
oard of BA experts; 2) Create the prototype using an iterative process of development and evaluation; and, 3) Conduct a feasibility pilot stu
nity mental health clinicians and other community practitioners in the utilization of this evidence- based treatment with adolescents. Speci
GTPase activity of modified Ga proteins. Based on the approach used previously at BellBrook Labs for development of an ADP detection as
hnology, and Dr. Anna Huttenlocher at the University of Wisconsin - Madison, who brings extensive experience in the molecular analysis of
sted for their effects on disease processes in the context of intact tissue as opposed to non-physiological monolayers of cells. In Phase I, we
of neurogenin (Ngn) 3, a marker for pancreatic endocrine progenitors. Once a HuES based progenitor assay is in place, we will then transitio
astasized prostate cancer. In the specific aims of this project, we propose to evaluate the preclinical benefit of Bexion's treatment agent on

e achieved by combining lower-load SC with higher-load LC training which is particularly attractive for older and energetically impaired adu
, and also simultaneously acquires physiological data from conscious and mobile subjects, could increase the value of pigs to human health

pressing, and characterizing new enzymes for chemical synthesis applications, we have brought to the market more than 150 different enzy
basal and squamous cell carcinomas generate large electric fields in human skin as well. In our Clinical Trial we found that the hand-held BF
ase I proposal is to engineer a comprehensive device and procedure coupling non-invasive MR diagnostics with minimally-invasive MR-guid
ation of molecular, genomic and clinical data that results in increased efficiency in discovering and validating molecular targets. In addition
nically respond to the TKI, gefitinib or erlotinib, develop resistance to these agents. The emergence of a secondary mutation in EGFR (T790
using a combination of single nucleotide polymorphism (SNP) markers and microsatellite markers. Finally, we will evaluate the replication
he performance of conventional devices. Existing UF devices have inherent limitations which result in slow filtration, high variability, and
aerobic, microaerophilic, and anaerobic bacterial species, with special emphasis on those important in human disease and/or biodefense
ed Micropower Impulse Radar (MIR) technology. This device emits very low power radio frequency impulses of a very high frequency and b
sion molecules such as P-, L-, and E-selectins, a1, a2-, and a4 integrins, vascular adhesion molecule-1 (VCAM-1) and intercellular adhesion
lectin inmunoglobin chimera, and on its form of application. The cross- linked compound forms an adhesive matrix over damaged, lacerate
) technology, a time-enabled geographic approach that displays and analyzes spatio-temporal datasets. The specific aims of this project wil
osures, socio-economic conditions, proximity to screening centers, leading to: (1) a better understanding of the causes underlying observed
he methods so derived will be applied to evaluate clustering of residential histories in an ongoing case-control study of bladder cancer in so
which if left unchecked or unmanaged could lead to blindness. This Phase II research is dedicated to developing technologies that assist ph
to help reach this objective, we propose investigating the possibility of integrating microfuidic particle sorting technology developed under
tide haptens to carrier immunogens such as KLH. The new production method will be amenable to high throughput production of high qua
ection such as FlaB, OspC, VlsE, BBK32 and DbpA. None of these antigens is adequate when used alone in serologic assays. However, in com
ected all vaccinated mice from B. burgdorferi infection after tick challenge. In addition, these anti-OspA antibodies cleared B. burgdorferi f
o screen abnormalities in GFR is serum creatinine. However, estimated GFR values using serum creatinine have limited diagnostic value ove
oped IVST nano-particles and to compare a variety of coatings that can target IVST particles to specific cell types. IVST will allow researche
cedure for the production of stable lanthanide oxide colloids. Preliminary data demonstrates that the gadolinium oxide colloid is stable in a
ble form but so far, there have been no reports on the presence of soluble TL1A in the body. This was largely due to the lack of a sensitive a
pathogenesis of bacterial infection and sepsis. Therefore, we propose to accomplish two goals in this Phase-I STTR study. First, we propose
nt OCT imagers commercialized to date have been built into standard tabletop slit-lamp biomicroscope designs. The resulting systems are b
meet the rigorous needs of an HIV viral load diagnostic for point-of- care use in resource-poor settings: rapid, easy-to-use, automatable sam
of lsGG- mediated single- gene target replacement as a function of DNA length. The DNA donor sequence will be comprised of synthetic DN
mation of a fuorescence-quenched probe (e.g. DNA linearization via hybridization), cleavage of the probe (e.g. proteolysis of peptide substr
pileptic patients. In collaboration with the Seizures Disorder Center at UCLA, we will 1) develop a user- interface for remote configuration o
sistency of pronunciation. A new type of technology, voice transformation (VT) technology, is available that can transform speech spoken b
hat there is little variation in this protective biofilm along the colon and ileum. Our initial observations also indicate that the lumen/stool m

ors experienced by this target population. The commercial success of Black radio comes from an ability to address the unique cultural nich
e aqueous aerosols which following evaporation and concentration were delivered as respirable concentrated dry power aerosols at a conc
ed in ca. 1.5 hours. The platform is "open" in that it can identify any bacterial organism that has been previously sequenced without the a p
ursued for application in diabetes research and therapy. The ultimate objective of the proposed research is to advance our fuorescence sen
that can be used for multiplex detection together with existing popular fuorescent biomolecules such as FITC, Alexa 488, Rhodamine, Texa
a planar patch clamp experiment to succeed, several events need to occur (assuming that the cell expresses the appropriate ion channels in
o operate and easy to carry, store, recharge, don and remove. Advanced options are hidden during day-to-day use, but easy to access when
ccurately with fewer risks and costs. Phase I Hypothesis: The combination of image-based planning and surgical navigation will improve the
macokinetic studies were performed in rats to verify that the addition of an inert polymer extends the circulating half-life of interferon gam
s efficacy in animal models of RA. During Phase I, we used the published structural information for soluble VEGF Receptor I (also known as
al aberrations of the eye that encompasses more than 90% of the range found in the population. The long-stroke MEMS deformable mirro
sis states that the instantaneous ratio of the expired partial pressure of CO2/O2 at the end of the alveolar phase of steady- state tidal breat
e healthcare costs, and save lives. Encrustation results from mineral incorporation into biofilms on device surfaces. These deposits inhibit d
selectively killing or inhibiting the cariogenic bacteria within a pathogenic Dental plaque, a non-pathologic, commensal microbial communi

scovering diseases earlier, and optimizing and individualizing treatments. We intend to focus on the development of technologies that will
ing BRES that can identify exposure to particular chemical forms of toxic metals. Protein:metal adducts formed in individual patients may b
D. Equipment available for this work includes: fume hoods, sterilization ovens, reaction glassware, rotary evaporator, vacuum lines for reacti
k or reverse SOD1-based protein mis-folding or the toxic effects thereof, and to evaluate these compounds as potential therapeutic candida
validated this cellular assay by identifying several histone deacetylase (HDAC) inhibitor compounds that transcriptionally activate DJ-1 bot

o provide a simple tool to the healthcare provider and health consumer community for ongoing bedside assessment of hydration status in

myocardium, resembling but distinct from the cells in bone marrow that account for most (if not all) long-term self-renewal and the fullest m
due to the ability to better deliver drug intracellularly and for extended periods of time. Carigent Therapeutics has developed a methodolo
te values of SctO2. More importantly, it is necessary to establish threshold StO2 values that correlate with patients' clinical outcomes for
eatment through educational services and technological innovation. CARE intends to develop two BASICS DVDs that will demonstrate moti
CBC's potential immunomodulatory property. Although a typical reduction in cerebral A? plaque burden has been associated with an impro
Verification that the licensed culture methodology results in the production of islet-like, dithizone positive clusters of progenitor cells from
define the stress response pathways activated in hLC during common pre-transplant manipulation and processing. It is the intent of these s
ryosurgical device (CryoInject(tm)) for treating recurrent prostate cancer. The reasoning behind the development of the system are as follow
ment of prostate cancer. The reasoning behind the development of the device are as follows: (1) NeuprosolTM will be applied directly to th
We will first screen several acetylated-lysine monoclonal antibodies to select the one that performs best as an immunoprecipitation reage

o PhosphoSite(r). We propose to significantly reengineer PhosphoSite(r) to accommodate this abundance of data and to update the interfa
n saving people's lives in clinical trials and reducing the amount of animal studies. The Phase II proposal is to continue the awarded Phase I
le libraries. The long-term goal of the current grant application is the development and commercialization of next- generation HTS technolo
ropose to develop a FV human shRNA library in biosafe lentiviral vectors targeting 5000 pharmaceutically tractable gene families that are a
a genome-wide scale. The ultimate goal of the proposed project is to develop and make available in public domains a genome-wide databa
subpopulations collectively referred to as myeloid progenitors that give rise to granulocytes, macrophages, dendritic cells, erythrocytes and
fow centrifugal system, which is widely used in developed countries but is expensive to set up and operate, and gel filtration method, whi
rogression and treatment efficacy. Improvements of nucleic acid detection technologies such as the introduction of real-time PCR have con
on of cardiac toxicity, but adult human heart cells are not readily available and cannot easily be maintained or propagated in culture. Cellul
e serious adverse consequences with this current practice such as: Excessive cost of manual verification, High false positive rate due to hum
m optical throughput, offers a technology that can be readily reduced to a handheld form factor and is thus adaptable to portable, point-of-
ovide lower impedance elements and a reduction in mechanical stress during fabrication, but also provides inherently better imaging due t
romechanical coupling coefficient (k33 > 90%) which provides ultrasound transducers with an inherently wide bandwidth. In the Phase I pr
differentially-glycosylated analogs - due primarily to the severe limitations imposed by classical glycosylation methodologies. The studies p
er cell cytotoxicity tests, revealing an unexpected but potentially very useful infuence of sugar structure on biological activity. They exhibit a
rom ischemic pancreases. To this end, a prototype pancreas transporter (PTR) has been designed and constructed in a previous study that d
hite blood cell count. An assessment of red blood cell and platelet morphology should also be feasible. The new system could be used in th
c and commercial needs, CertiChem (CCi) has completed a Phase I SBIR grant showing that it is feasible to develop an anti- EA robotic assay
molecule, which has received special attention in the last few years. Combretastatin A4 phosphate (CA4P), a water-soluble prodrug of CA4,
tomic Venture Partners to its executive management team on a part-time basis. AVP is an early-stage VC fund that invests in pharmaceutica
ases and cancer. The application of thalidomide and its existing analogs in the treatment of retinal neovascular disorders is limited due to th
is considered to be essential to prevent disease progression to renal or hepatic failure, and/or massive pulmonary hemorrhage. The major
tion technology. The proposed gene expression profiling system will achieve these characteristics in a new type of microarray. This project
esearch has already shown that growth of such ACC gene-replacement strains is inhibited by compounds targeting foreign ACCs. We have d
llowing Specific Aims: 1) to functionalize fibers with As-selective ligands, 2) to measure As adsorption by the functionalized fibers, and 3) to
of these candidate biomarkers will be useful in predicting premature cervical dilatation and preterm delivery in asymptomatic pregnant w
for assessment and treatment, in the prototype for Phase II, of the African-American breast cancer patient (AABCP). When completed, this
apability to perform hundreds of individual functional cellular assays simultaneously without the use of molecular labels. The system will e
n molecular diagnostic approach will provide the clinician with a powerful tool for early detection, classification, and prognosis, assessmen
elop an automated T cell analysis assay to identify and functionally characterize autoreactive T1D antigen-specific CD4+ and CD8+ T cells ca

ple of all ages every year, in the United States. Little innovation has occurred in decades to make this procedure more convenient for patien
ositive and false-negative diagnosis rates. Several clinical features have been correlated with early PD including motor function, olfaction, he
dy new therapeutic approaches using in vivo or in vitro models of the BBB, many of which end up not working. Rational CNS drug design ca
opment of an innovative website for dementia caregivers. APPROACH: The prototype website was developed in Phase I and is available on
cent of those recruited completed the module. Respondents ranked the clinical applicability of the epidemiology risk factors module very h
nd cognitive function will be evaluated. In addition, pharmacokinetic properties and the safety of CDD-0304 and related compounds will be
nerated novel transgenic mice that express human vasculotropic Dutch/Iowa mutant amyloid a-protein precursor (AaPP) in brain, designate
measures of a panel of representative infammatory mediators. Specific Aim 2: Using a DSS model of acute colitis, measure the response to
ammation plays a significant role in development of PD. In addition, there are a number of reports that characterize genetic factors that inf
we have demonstrated that COG133 improved outcome in a preliminary sepsis study using a murine cecal ligation-perforation model. In or
ation; and 2) apoE may affect myelin-forming cells (oligodendrocyte and its precursor cell) proliferation, differentiation and survival during
ase. We EXCEEDED our aims by identifying a new, more potent analog, COG112, which resulted in nearly 100% remission rate in EAE. This P
here small bone fragments during internal fixation. The hypothesis of the proposed Phase I research project is that Cohera's proprietary bio
that will be effective in closure of planar tissues based on its physical properties, delivery process and adhesive strength. Accommodating t
na ve T cells. The speed with which these topical adjuvants promote protective T cell immunity, their low cost, and physical independence
ual errors determined in pre-training assessment. Training will begin by strengthening the bottom-up processing skills at the syllable level an

solvent recovery enhancing chemical reactions, chemical industry solvent recovery, manufacture of fuel grade ethanol and stabilizing indu

over-all objectives of this proposal are to synthesize novel puerarin analogs and to evaluate the potential of these compounds as hypoglyc

a prototype, computerized instrument to be developed during Phase II. A primary focus will be on binaural assessment of patients with bila
c range permitting sensitive detection of trace species in an air sample where other chemical species may be present in high concentration
headaches (Stewart, Shechter, & Rasmussen, 1994) and differ even according to the definition of pain, ranging from 3% to 37% (e.g., Von
ailable computers. Specific Aims. The Phase I specific aims are as follows. (1) Select the appropriate mPBE theory that both captures the im
ery: radial keratotomy, LASIK faps, penetrating keratoplasty and cataract excision. The results confirmed that the laser solder approach is s
this technique used a commercial grating based spectrometer, liquid crystal (LC) filter technology, one the core competencies of our team
reconstruction plates take the contour of the jaw, the distraction devices have a linear vector. The devices also have a limited distraction dis

omparability, respondent burden and acceptance of parallel versions of the LLFDI-Fixed and LLFDI-CAT in a pilot test with a sample of disa
neuvered from room to room, easily installed for single or multiple transfers, easily removed and relocated to new facilities, and appropriat
pital comparison tool that will address gaps that exist in current hospital ranking systems using advanced statistical and econometric model
cacy and availability of TRS4000 exercise for a significant percentage of potential users. We anticipate that successful implementation woul

methemoglobin. In the treatment of methemoglobinemia, it is necessary to be able to measure the methemoglobin fraction accurately. A

s been used to develop the Cell Xpress(tm) application to address these market needs. Phase I results demonstrate significantly improved s

al scaffold made by a new three-dimensional (3D) weaving technology and a novel, highly scalable cell culture device. Maturation and grow
in the best candidates for therapeutic purposes. The detailed HTS assay for development will use cytotoxic T lymphocytes that recognize th
peutic strategies to alleviate acute/chronic pain. Phase I studies will focus on pharmacological profiling (dosage, route of administration, bio
orm cell sorting and functional studies to identify the population or populations within adipose tissue that possess properties consistent w
fail to result in appropriate samples. Clearly, ancillary approaches are going to be required to fully implement a knowledge-based approach
s, training, and tools needed to effectively teach students with AS/HFA to successfully complete these tasks. Using a modular design, STRIV
s that reinforce content, and includes homework assignments and personal exercise sheets, and 3) A DVD with modules for both counselor
ed from others. Because of the lack of resources for this population, Danya International, Inc., proposes to develop, evaluate, and promote
welkiewicz, DeFrancesco, & Adnopoz, 1992). The proposed FETP, a multimedia training toolkit consisting of a Web-based training program,

ated into existing treatment centers and will specifically meet the developmental needs of adolescents ages 13 to 18 and their families. Thi
persion is also very common in such data. The major interest of this project is to investigate the analytic methods for continuous and discre

heir adherence ranges from poor (50% doing less than prescribed airway clearance regimen) to very poor (30% not doing any prescribed tr
h Borderline Personality Disorder series will experience: (1) an increase in knowledge about BPD; (2) an increase in their sense of empower
middle school, in particular, prevention programs that address the developmental needs of adolescents. MSC will cover the effects of alcoho
e II application will be submitted for completion of preclinical studies required for IND submission. BACPT and BACPTDP are novel camptoth

ranslation research of existing research findings (not anecdotal care information) related to sleep behavior disorders of demented individu
ata items will be delivered in a geodemographic information system, AllocateChina. This Phase I study, Small Area Demographic Estimates f
ation of instruments for improved soft tissue debridement through the small surgical opening used with MIS. The long term goal is to prod
research literature but remain insufficiently recognized by the drinking public. We propose to develop a Web-based RBS training program a
wledge of oral and physical manifestations of eating disorders, and skill training in patient approach and communication with patient's suffe
itro test), as well as for solubility, central nervous system receptor activity, and cytotoxicity. The most promising candidates will then be eva
ndent identity. Following an assessment of a variety of methods for deriving local area estimates from the HRS data, the system will produc
ew criteria for assessment of HBeAg and antibody to HBeAg in vitro diagnostic devices". Results of the pre-clinical studies will be presented
udy is to apply DCP, newly optimized for human plasma, to the discovery of biomarkers of diabetes using appropriate patient plasma samp
vide a fast, cost-effective process for performing differential proteomic analyses. It will accelerate the pace of biomarker discovery and also
nts and providers. A link will be created with the study hospital's electronic medical record to integrate medication details directly from the
ested for reliability on these diverse voice samples. Through a second study of fifteen depressed patients over eight weeks, the SPIMA inde
y amplified luminescent readout. In order to harness EFC to measure allosteric regulation, we will insert the EA and ProLabel fragments into
tive enzyme that can catalyze the formation of a luminescent product that can be detected photometrically. We have begun to adapt EFC t
y therapeutic transgenes. The Specific Aims of the project are to: 1. Construct a Liver- directed Targeting Tether (LTT) vector system to incre
oson DNA and RNA into cultured hematopoietic cells, and then correction of human lymphoblastoid cells deficient in Fanconi anemia comp

seBusters hardware. Phase 2 of the project expands on that concept by integrating a talk-through circuit into the dosimeter, and also strives
face the campaigns to reduce onchocerciasis with ivermectin. The long-term objective of this project is to develop new compounds with '
y reconfigure itself during imaging to produce the most accurate, high-quality images of histology and cytology specimens. The long-term g
ent thermodynamics, NOT by sequence similarity. Thus, BLAST is not appropriate for the task of improving hybridization stringency. For seve
he following Specific Aims: A. Further develop our scanning technology by improving the software for data acquisition, analysis and report p
addition, these gains will be achieved in a platform which permits routine double-resonance, thereby enabling cross-polarization, de- coup
voiced the need for major increases in rf field strength, as required for significantly improved spectral resolution, along with dramatically re
de NMR sample preparation methods. This project seeks to develop sample preparation and storage devices used in Nuclear Magnetic Res
ut structure for charge readout. Dose reduction will be achieved due to the very high sensitivity of mercuric iodide films. We expect to wide
using the technology proposed in the product presented here. Instead of integrating the x-ray current over a time, photon counting is used

ships during supine resting condition, and during the Valsalva maneuver and the sit-to-stand test. The MMPF analysis decomposes comple
DNA antibiotic screening will be modified and made compatible for efforts to integrate these advanced E. coli heterologous hosts into env
tanium and nickel due to catastrophic diamond tool wear. Current technical solutions for extending diamond tool life only achieve limited s
n light of the phenomenal increase in the prevalence of childhood obesity in the United States and worldwide, BCA during infancy has the p
and avoid the spread of infection. The diagnostic device will be based on a novel detection method for pathogenic bacteria that was deve

is to develop quantitative mycotoxin sensors for precise assays and also to develop semi-quantitative mycotoxin sensors for rapid field assa
here are major clinical problems in management of this disease. Destruction of the gingival tissue in periodontitis is mediated in part b
human SLPI has been successfully overexpressed as a 16.4 KDa "polyhistidine-tagged" protein (HisSLPI) under regulation of baculovirus prom
orm, the captured folding intermediates can be released from the chaperonin using osmolyte solutions or mixtures of osmolytes. This syste
gy in real testing situations, practice activities, and checks for understanding. To test the efficacy of the programs, revisions to each program
 ent of new ultra low noise electronic readout architectures for biology, the group of Professor Henry White, the inventors of the new suspe
ces, such as the Ca channels. Secondly, these systems are unable to reach a large enough bandwidth to detect many short duration single c
i4Pacs(tm)). The SciPac(tm) product line will emphasize current biology and technology concepts for middle school and introductory biolog
ticide exposure to a worker by irreversibly binding any pesticide that comes in contact with the SERS sensor. The sensors would also measur
novel development and optical imaging process, to yield the protein concentration in the sample associated with each MRA. The arrays ca

he monitoring of myocardial infarction (MI). A high spatial-resolution method that can distinguish quantitatively between areas of infarct a
tion of children with special needs, engaging 3 centers in the study to demonstrate universality and quantifying outcomes over a period of
ularly rich source of "druggable" natural products. Traditional methods have been used to discover over 7,000 antibiotics, with the result th
nd kidney transplant patients.
ng research to practice from the program to the individual prevention practitioner. It also changes the focus of the research to practice tech
ble on a local level. What is needed is a systematic and fexible analysis template that will guide users in a) extracting and transferring relev
and instead rely on using an AAC device that generates synthetic speech. In devices that are currently available, users have very limited con
rgins in patients undergoing breast conserving surgery (lumpectomy). The optical device will provide non-destructive evaluation of approxi
ns. The goal of this project is to develop a biocompatible and biodegradable in situ gelable carbohydrate hydrogel, without the limitations o
ve hitherto shown limited success. Liquid embolic agents have been developed but their performance characteristics have to be greatly im
ergetiq light source can be used to generate light needed to illuminate and image biological specimens in a soft x-ray microscope. In Phase

ticle collector, and we will interface this particle collection system to a microfuidics card where biological or chemical assays will be carried
al system for detection of arsenic in drinking water at concentrations between sub-ppb and many ppm. The performance of the instrumen

n structures from any angle. Viewers will be able to select brain structures and learn about the specific mental tasks they are thought to pe
uperior to those currently in use; and 3) Future development of reagents to prevent alloimmunization to blood group antigens. HDN has be

sure resistance of ventilated patients and made as portable as a camera. We have used APD it its current implementation to measure avera
n Phase I we propose to prepare rabbit embryonic fibroblasts as feeder layers, synthesize recombinant rabbit leukemia inhibitory (LIF) facto
ent standard-of- care fibrinolytic treatments. We have generated novel small molecule PK inhibitors displaying both high potency for PK inh
human derived antibodies against infectious diseases, extending the benefits of vaccination to diseases for which a mass innoculation cam
ed to very high concentrations (up to 10 mg/ml), not possible with other non-viral gene delivery systems. This technology will allow for the
in, by corneal epithelium, binds to syndecan-1 and is cytoprotective against TNF, which suggest that lacritin may also have beneficial anti-in
orm generates a unique signature that can be quantified based upon novel antibody sandwich pair formation. The specific aims of this app
rformed in resource-poor environments, requires no expensive equipment, is robust with respect to environmental variables, and can be ex
rse of the SBIR award period, selected epitopes will be formulated as DNA and peptide/protein vaccines. By means of a prime-boost vaccin
per T cells. We thus propose to develop a de- immunized version of FVIII by T-cell epitope modification. FVIII contains highly immunogenic T
minutes. Great separation speed and easy method development of ESI-CIMS-MS make it the method of choice for many applications analy
me, point-of-use measurement of ethanol concentration with preservation of samples for later analysis, if necessary. The applicants have co
s, a healthcare provider if medication is not taken as prescribed. We will explore FDA approved "generally recognized as safe" (GRAS) comp
thesis is that these atherosclerotic-targeting endohedrals (ATE or Gd3N@C80-derivatives) can be endocytosed by macrophage foam cells fo
t2. These prototype assays will be used to monitor the intracellular kinase activity of the exogenously expressed Akt2 and activity of the en
date) into fibroblast-like cells that morphologically resemble preadipocytes, and 3) the de-differentiated cells can be culture-expanded and

lines is phosphorylated on threonine residues while FAS from non-transformed cells is not phosphorylated. These findings will enable the d
harbor in their genome. Once the strain improvement target is identified, new genetic and metabolic knowledge is revealed that can lead
d any information regarding the genetics or biochemistry of strain improvement. This study will pro- vide important information and techn
lasma using blood samples from 800 neonates, (2) determine the effects of potential interference from conjugated bilirubin and bilirubin is
 e caught and remain trapped in the initial infammatory phase of wound healing. FirstString Research, Inc. (FSR) is a biotech company loca
ations that are unavailable at the present time: selectivity of a probe as if it were a long oligonucleotide, but discrimination by the probe a
biological mechanisms involved are not fully understood. Pathologics seeks to leverage its proprietary Arrayed Imaging Refectometery (AIR

ns the system will enable by getting input from nurses through key informant interviews and focus groups. (2) The company will then collec
ndrocyte proliferation, and the spatial distribution of the collagen cross-links forming adjacent to the chondrocytes in the extracellular mat
zyme and protein-peptide binding assays will be demonstrated. 2) Automation of fuorous-based carbohydrate synthesis. Using a commerc
(1) drug safety testing via hERG screening (2) integrated transfection of an ion channel construct and ion channel recordings via patch clam
major areas of further development are proposed: (a) implementation of advanced online features of the SSP and ESSP assessment tools an
plant capable of both sensing IOP and regulating it through opening and closing a miniature valve. The implant's power supply will be self- c
ts that enable cells to become resistant to HIV-1 infection. This strategy has been used successfully to identify genes whose homozygous p
hold their breath. To take full advantage of highly parallel imaging and the concomitant enhancement of disease diagnostics such as detecti
androgen therapy may be indicated, this same population is also at a higher risk for stroke or developing such neurodegenerative diseases
ork is made possible by our synthesis of analogs of the antidepressant venlafaxine. Unlike venlafaxine, our compounds are triple re-uptake
he integration of advanced intrusion correlation and sophisticated mission modeling can provide the basis for effective situation awareness
of AMM microstructures, in order to ensure that the proposed materials exhibit the desired, complicated and unique elastic properties. Th

design a candidate Forward Looking SONAR with the Toolkit, incorporating single crystal piezoelectric material, to replace the existing Tonp
e School in Monterey, CA. This technology, once demonstrated in PDEs, can be adapted for use in other Naval, military, and civilian engines.
hms would migrate to the RFSQ sub-system). The proposed TIPS design employs a truly open architecture philosophy based on COTS hardw
uctural responses. We will use the FLEX computational structural dynamics code plus existing test data to generate a damage data base tha
s also proposes to design the Advanced Interceptor Data Link with new ground-based and fight-vehicle transceivers utilizing the proposed
work testbed. In addition, definitions and updates of intrinsic intent of DOD policy /process for key/certificate distribution and policy man

duct a series of field experiments to demonstrate the feasibility of the proposed BRDA system from which we will develop a detailed design

stent surveillance.
otocols as a function of MANET capabilities, MANET link failure behavior and optimization metrics of intra-networking protocols. A multi-m
loped in languages such as the Architecture Analysis and Design Language (AADL) and Unified Modeling Language (UML). The effort propo
pment under this SBIR program will allow the measurement of heat fux through the TBC.

SELF verses OTHER approach to information leakage detection by leveraging and applying proven aspects of previous work including ontolo

nsumption and communication failures. Emperor Radio consists of an ultra-low-power transceiver with software-reconfigurable modem an
wer distribution system.
tionally the system will use acoustic arrays capable of determining a bearing to the target, which will be used by higher level processing to d

the preliminary design. The testing program will focus on evaluating the demonstration hardware in as close to a “deployed” configuration

ystem by the end of Phase I.

m complexity. Since a very small amount of oxygen is needed, the overall system density is reasonably high.
dage power loss of at least a factor of 2, with a goal of an order of magnitude or more.
cal Radio System (JTRS) Software Communications Architecture (SCA) and will be designed to accommodate emerging and future SDR stand
real-world systems operability and fight test data for AFRL. Fourth, the vehicle will be able to conduct spacecraft testing and checkout for
ge for all outdoors display systems in general. We will solve this problem in a way no other systems have used so far ------ automatically adju
ous simulation and modeling technologies through a tool bus technology that supports theorem proving, model checking, simulation, Mar
ilities to meet system stakeholder (managers, developers, certifiers) requirements. Our previous work on model based analysis for system
significant development and life cycle cost savings associated with reducing safety certification efforts and improving performance certific
ngine, and mass storage device.
a basis on further development of the tools for wide range of applications to military and commercial SATCOM planning and operation.
nt modeling, and OPNET simulation model. The Phase II effort will provide the prototype model software to be used for the SATCOM desig
ar beam can also supplant measurements during daytime hours from locations where forward scattered light pollution from the sun’s direc
d automatically activate upon release. While in fight, the dropsonde will telemeter PTU, GPS winds, and sea surface temperature to low ea
l recommendations and serve as the basis for prototypes developed in Phase II.
other, optimized or even tested relative to the needs of naval aviation systems. YTP proposes to conduct this research as part of a Phase 1
ut in excess of ten (10) hertz, and the ability to track horizontal and vertical position even in the total absence of GPS. Because the propose
I. This Phase I effort will culminate in a high-quality proof-of-concept design, testable prototype, and quantifiable performance results. Th
atural phenomena; to design algorithms for detection of underwater physical processes in microwave imagery of the ocean surface; and to

gles, with 5X optical zoom and weight of < 20g and scan time for the 80 degrees in < 30ms. We will assess the feasibility to achieve these g
D system perspective. Computed solutions of CEFM for the F-16/HT cases will be compared with those of ZAERO. Based on the computed C
bine the nonlinear structural morphing ROM (extended ELSTEP) with the nonlinear aerodynamic ROM (using nonlinear system identificatio
hts should be eliminated, (7) the effects of the dust, dirt and moisture to the sensor window should be prevented. The key of our new desi
ahertz spectroscopic measurements on threat vapors, many for the first time.

g the missile.
AMT will continue to grow and explore the Eddy Current Braking model with its mechanical engineering research team at the Georgia Insti
n Systems, Teledyne Imaging Sensors, DRS and Lockheed Martin in order to ensure as rapid a transfer as possible of this manufacturing tech
fexible glove and will provide development on the system design for additional thermal protection and hand warm-up.

gated for digital/analog full custom, semi custom, standard cell, and programmable array architectures. These results will become the base
) Development of Optimization Techniques for Compensating Residual Nonlinearity and Cross Talk, (d) Development of a Navy-Relevant Po

the defects, i.e. traps, responsible for the tunneling current. Amethyst’s research plan also includes parametric studies to optimize passivati

ods lead to a direct assessment of this phenomenon, and we will use this to study the strength of the link to motion sickness susceptibility.

rosthesis. The socket adapts itself to the changing physical shape of the residual limb as the prosthesis is worn. The adaptation is a natural

plicable to the civilian population in regions where mortality is high due to the prevalence of vector borne diseases.

. As a result of the Phase II program, IST and CDI will supply pre-commercial prototypes to the USMC for evaluation.

tion beyond the bone conduction limit. Our plan includes the proof of feasibility of this device, as well as complete system design and part
, and prove our preliminary concept using virtual testing. In phase II, the concept will be fully tested and proved, and a prototype will be co
nto ongoing radiation resistant coverglass development testing. Phase II prototype coverglass interconnected cells (CICs) fabricated with t

ar. Each individual subaperture data provide pertinent information regarding the moving targets in the imaging scene; however, the data ex
ration article in the Phase II program. The Phase II will culminate in the fabrication of an electrical circuit or communications antenna embe
 option formulation.

workscope, in a seamless manner for a high-level of functional integration between modules. The Phase II Option portion of the workscop
roblem, and have developed an innovative and novel approach to meet the needs of the United States military, that is both realistic and ac
al parameters that withstand multiple uses, extreme temperatures and austere environments.

metric. We will use our aeromedical and biomedical expertise to develop an unobtrusive sensor that can provide real-time feedback to th
e II, we will refine the coating morphology and process conditions, coat prototype components for more-extensive testing, and develop a U
d collaboration with Bluefin Robotics, Ultra Electronics, and the customer. The final objective of the option tasks will be to evaluate the rep

m the US Army Human Terrain System (HTS) because it provides Naval forces the capability to conduct assessments using organic assets, a
be the choice for the solid state electrolytes, and may be used in conjunction with liquid electrolytes. In addition, the application of ionic
ll be active participants in both the Phase I and Phase II programs to ensure incorporation of the technology into deployable systems.
ent of a system that has been successfully in use for decades. In Phase I, Infoscitex will design the overall system, fabricate prototypes, and
ower drop through the channels
anufacturing scale will provide materials with a cost per unit volume less than copper at 1.5 to 2 times the thermal performance and CTE m
NSAIDs in the above in vivo model systems to confirm Indomethacin-PC’s superior GI safety. The parenteral and oral formulations of Indom

emonstrated at a scale of at least 500 grams at a pilot plant scale while maintaining a high Figure of Merit. This pilot material will be valida
discussed. A conceptual design of the integrated 250 Watt SOFC-TE power system will be created.
and development of printing, imaging, and marking consumable supplies.

s of symmetry in the lattice. Advanced stable NLO EO polymers will be synthesized by UW and 2D polymer PhC designs and fabrications wil
systems developed on this SBIR can be directly applied to improving EHM performance for the F135 and other gas turbine engines.
icrostructured arrays and plasma lysing. The relevance of this effort is to rapidly provide nucleic acids for biodetector applications in a min
utlines a plan to address this critical need for advanced PHM technology with a combined hardware and software systems approach. This a
e thruster can be operated with a wide range of propellants from hydrogen to xenon. The physics of both the plasmoid formation and acce
ment without significantly limiting bandwidth. Photonic band gap devices will attempt to exploit recently developed NLO polymers with exc
helmet mount configuration.
ta and sensors information from sources not typically available on current BMDS fight tests. Development will lead to cost effective enhanc

of HyperX based chip products, will be available COTS in the Summer of 2007. This effort capitalizes on the investments made by DARPA; U
II. Demonstration weld repairs will be made on prototypic mockup parts and metallurgical and mechanical properties will be evaluated to

ts such as component failure, fuel loss, and energetic material reaction for multiple projectiles such as targeted by standoff kinetic missile e
p of the POSS derivatives and application variables during Phase I and select a set of promising POSS formulations for Phase II developmen

del geometry. It integrates geometric reasoning, feature suppression, and dimension reduction methods to support automating the constr

he absence of a database of degradation signals.

proach the detection performance of existing compute-intensive systems for pedestrian detection; operating the pedestrian detection algo
e achieving designs that are significantly smaller than all those that are currently available. The proposed miniature inertia based igniters f

and simulation platforms for performance evaluation purposes, and demonstrate the effectiveness of the solutions using physical experim
t conducted a technology feasibility study and considered alternative strategies for an AIT enabled system to provide tracking/in-transit vis

e art coring approaches. BENEFIT: POTENTIAL NASA COMMERCIAL APPLICATIONS ( Limit 1500 characters, approximately 150 words) The
Vehicle (HMMWV). The proof-of-concept demonstration will focus on the ability of the EATR to recognize biomass sources of energy from

e Phase III system, but with 1/4 the ground swath coverage. This system can then be fully populated once funding is secured for Phase III.
nitiated inertial igniters will be manufactured using well established mass fabrication techniques and equipment, and should readily satisfy

rate of 200 mL/minute over a 12-hour time period using less than 2 kg of starting materials.

ods and present a cohesive training and support program for future smelt growers. Our ultimate goal is to shift reliance upon a stressed wil

to be overcome to allow for a practical nanopore based DNA sequencing system.

es by measuring oxidation in a nanostructured thin film from NIST up to 250°C.

-1 wide and a minimum power per unit bandwidth of 0.125 mW/cm -1. In Phase 1 we will characterize mid-infrared generation and demon

ature will have commercial potential for marine finfish containment systems other than the AquapodTM. Savings in labor and reduction of
ment on a small UAV, and a second for measuring down welling atmospheric brightness temperature on the NOAA P-3 for improved low win
solution that leap frogs over today¿s commercially available technology, while providing fexibility and modularity to ensure a long life cy

ature of the equipment, the scale of the digester can follow changes to the farm¿s herd size. Avatar¿s pilot digester is based on the robust

us work. Each of these chemicals will be tested individually over a range of concentrations. Eon Research hopes to identify different express
oducing gram-scale levels of recombinant Zea m3 (ZM3), a maize HED2, and comprehensive testing of the recombinant protein for cellulos

ial applications for this water monitoring system include: monitoring surface water, monitoring source water at drinking water processing fa

nomically viable. It. is anticipated that tile application of the technology will significantly improve the economics of biodiesel production for

trated the technical feasibility for high purity water recovery from the fue gas with concomitant heat recovery. However, its payback perio
ire external feeds of Mg and TiCl4 offers the potential to produce titanium powder at one-half or less than the cost of a Kroll-produced spo

ncouraging design for the environment and extended product responsibility.

ng probes and a hand-held laser unit as backup. The resulting heat retention of the innovation is anticipated to produce substantially highe
ire external feeds of Mg and TiCl4 offers the potential to produce titanium powder at one-half or less than the cost of a Kroll-produced spo
ial applications for this water monitoring system include: monitoring surface water, monitoring source water at drinking water processing fa
ncouraging design for the environment and extended product responsibility.

eloped in previous work. Each of these chemicals will be tested individually over a range of concentrations. Eon Research hopes to identify

will focus on producing gram-scale levels of recombinant Zea m3 (ZM3), a maize HED2, and comprehensive testing of the recombinant pro

es and a hand-held laser unit as backup. The resulting heat retention of the innovation is anticipated to produce substantially higher burn t

economically viable. It. is anticipated that tile application of the technology will significantly improve the economics of biodiesel production

trated the technical feasibility for high purity water recovery from the fue gas with concomitant heat recovery. However, its payback perio
ers by providing aircraft domain expertise during the contract work effort.
menological approach with a physics (kinematics and geometry)–based approach for correlating vibration frequencies, magnitudes, and en
odied in the “Business Rules”. The CM-Watchdog, in a component or in a connector backshell “doghouse” will use the rules to assure that a

ore low cost; Phase 1 results show that Linden’s extruded insulation passes wet arc tracking, cut through, fammability, corrosion, solvent c

onsistent with the accurate angle measurement from Areté’s imaging sensor system. The Phase II program will develop a prototype imagin

o see-through brownout/whiteout conditions. Areté will marry its fiber laser based imaging lidar technology and our extensive experience i
ed by correlation analysis referenced to surface and sub-surface motion sensors. Rotation noise will be mitigated by configuring the vector
steering. Although the physics of OA is well understood in the detection of optical systems, it will be shown that the CHAOS design approa
re, an adaptable neural-inspired navigation system, and state of the art environmental sensors.

ld of View of 8º is set as a minimum threshold requirement for any design concept. The SBIR Phase I program feasibility study will identify

op an adaptive multi-waveform ladar approach based on our proprietary high time-bandwidth product unambiguous ladar waveforms. The
gnal-to-noise ratio, maximum detection range and range error and will be calculated. The tool will prove valuable for analyzing the effectiv
 coefficients will be directly calculated from the MTF data. Hyper-spectral backscatter and source normalization data will also be collected.
as the Fire Scout against modern, small targets.

gual speech with lip-sync, facial expression, gesture, proxemic, and haptic behaviors. • The incorporation of a library of over 600 "context a

s from Groups I and II, and they can be made with any combination of any number of these metals in any stoichiometric ratio, hence these

ation capabilities will also allow interactive manipulation of a simulation without the expense of transferring files from primary storage.
ve visualization environment. Commercial Applications and other Benefits as described by the awardee: The visualization system not only s
d H2O mixing ratio of outside ambient air during regular fights of commercial aircraft. The analyzer would require no human intervention (
will be retained for long term software testing and validation, and the last analyzer will ultimately be destroyed during shock and vibration

g and prognostics would enable substantial cost savings in defense and commercial aircraft maintenance particularly. The compactness and
) or shearography, which have all been proposed and investigated for this application. As a unique technology, MXLDV offers the prospect o
ace target for a laser beam propagating through a deep, turbulent atmosphere. This will reduce program risk and will lead to a robust brass
ncorporate state of the art electronic cameras.

eam on the selected area of a target through simulated turbulence. During Phase II, we will further develop the detailed engineering design
e environment, module assembly, and the effects of thermal and annealing strains. A prototype sensor capable of withstanding prolonged c
em. In Phase II, we will build a prototype system capable of tracking a hypervelocity projectile, and install it in the AEDC Range G.
pecially suited for scanning focusing schlieren, a technique for visualizing shock waves by observing distortions in light-dark edges in the ba
n of a comprehensive method which estimates the probability of defect detection (POD), which will assist efforts to identify and optimize th
ccurate wavefront sensor for precision metrology of a transmitted or refected wavefront, together with a projection system that covers the

nd filter characteristics, from which many different voices can be generated.

ation. The RVTS is a hardware system that transforms an input voice to a pre-determined target speaker’s voice. We are confident that the s

ming predictive analysis on Iraq data today.

Corporation will leverage their experience in developing inference-driven sensor management systems to achieve the goals of this SBIR. W

I of this SBIR. The work outlined in this proposal has received a letter of endorsement from Raytheon, indicating the strong potential that e
ework for cross-institution and cross-disciplinary scientific codes. Both of these software packages have large user bases in the areas of co
-time performance than other advanced tracking algorithms. Indeed, this innovative solution has garnered a commercial backing from Ray
g history of transitioning SBIR technologies to end-users and will work with the prime contractor to integrate the Bayesian Prognostic Failur
be capable of hypothesizing new attributes, new relationships, and even new types of objects in its representation space and thus yield mo
. By defining the defense plan’s phases and contingencies in terms of different optimization constraints and objective functions, an engage
an interlaced information fusion and adjudication network to enable effective decentralized, distributed fusion within operational and comm

ant shop foor automation systems and enabling Integrated Work Control Processes (IWCP)’s. Anautics will develop the proposed capabiliti
include Lean Transformations and Critical Chain Project Management (CCPM) techniques. Although these initiatives have successfully tran
at more than 2.0 kg/m3-day using the effluent from a research production tank stocked with tilapia. The problems associated with clogging
reaction kinetics by evaluating the effects of photoanode chemistry, light quality, applied voltage, pH, and salinity on the rate of ammonia

rame. Therefore, our objective is to develop a process to induce early maturation of catfish gametes in order to produce hybrid catfish in th
develop statistical algorithms for sonogram analysis and intend to include pattern-recognizing approaches such as ANNs. Finally, we will inve

will shed new light on mechanisms of Fe uptake in the gastrointestinal tract. Successful Phase I research lays a firm foundation for extensio

artner Children’s Progress with professors from Columbia University and Brooklyn College.

ent and powerful tool formobile information and communication.

e determining the best image analysis and indirect measurement methods to be used for our Phase II development. The ultimate goal is to
he currently underutilized hemicellulose fraction of biomass to fuels.

of a cost effective prototype rapid assay for NHP bacterial detection. These studies will be done in close collaboration with expert research

ding modified live vaccine (MLV) and traditional autogenous killed vaccine. It is anticipated that the PRRSV ARP vaccine along with the adva

development and evaluation goals for this Phase II project are: (1) prototype optimization of metalized FEP whole-air containers for CAFO
t of existing overhead lines by new buried facilities), or any other situation in which open-trenching construction is employed. The BIN ma

e can be accomplished through this effort coupled with our extensive background as the producer of the current research standard of eros
s such as upstate NY. The project outcome will be a stand-alone controller that permits real time, adaptive, control of the daily light integra

nded enhancements and demonstrate the suitability of the device in the commercially and scientifically important area of Poplar phenoty

be conducted with college-level physics students to ensure that the Virtual Physics Laboratory is user-friendly, engaging, and at least as effe

ring a desired mutant locus into the genomic DNA and inducing Rep in cells entering meiosis, many copies of substrate DNA can be made a

provide a major market for agricultural wastes and to provide at least a partial alternative to the use of expensive nonrenewable polypropy
Sense street parking information network system of parking meters. This protocol allows for informatin to travel to the central control syste

olyte that can be administered in medicator systems in the finishing barn a few days prior to transportation to the packing plant.

tly exist to interconnect silo networks. The objective of this proposal is to architect the enhancements necessary to allow different silos to

lifetime. The project has a high probability of success based on the recent development by Adelphi and Lawrence Berkeley National Labor
s a perimeter protection system for offshore assets and highrisk Navy platforms, and a surveillance system for commercial cruise line shippi
round and air vehicles.
Phase 1 project, V-RADS will be upgraded and integrated into existing security systems, providing an additional layer of protection against il

ass of rootkits than previously attainable. An additional benefit of our research efforts is that the (platform independent) algorithms we de
mmercial trace explosive detection technology.

; 2) Ability to simultaneously reject scattered background and uptake from other natural sources; 3) Ability to interface with current installe
eate a feasibility plan for the following key enabling components of AIDnet: (1) ultra low power mote-based embedded hardware (2) distrib

ble unit that can be mass-produced and deployed in a wireless network on a large scale. The detector is very fast and, in addition, can provi

ative to existing generators will create dual use market opportunities in commercial, DOD, and homeland security applications. Although th
a complete working prototype DMS will be delivered to the government to conduct further testing.
(e.g. document sharing, email) applications. Based on the confirmed feasibility, during the proposed Phase II effort, the team will impleme

o user groups (law enforcement), police offices and government personnel. Ongoing interaction between Cybernet and users of the MVS (s

first responder response time can be improved when provided in realtime with accurate situational awareness.
tional. Essential SINBAD capabilities will likely include: virus detection, PuriFile scanning,in depth file type verification, sender/receiver valid

on stopping the vehicle by completely ensnaring it or fattening the tires rather, our device stops the vehicle by ensnaring the smaller, lowe

est the quality of the deposited material. In the Phase II, devices will be optimized and a prototype of a commercial boron deposition syste
and overall health condition; 3) communication protocols to transmit sensor and health feature information to appropriate devices for proc
ollection traps commonly employed in the explosives detection industry. Alternately, a manufacturer s proprietary wiping system may be e
a Maximal Entropy (ME)-based data classification approach. Different from the existing the classifiers the proposed ME-based classification

cal sensors that are deployed in industrial control systems.

install, and can quickly identify and monitor significant hot spots and their locations in the tunnel, providing key information to rescue and

ass of rootkits than previously attainable. An additional benefit of our research efforts is that the (platform independent) algorithms we de
 r firing and will allow for administration of additional doses to the target as required. Potential applications include the military and law en
tem that will allow captured explosive particles and vapor to be thermally desorbed for detection by a commercial explosive detector. It wi
structed and tested in phase II. Potential commercial opportunities include search platforms for rescue, police, homeland security and defe
tic law enforcement groups.

m several different technologies.

neration prototype using simple, low-cost digital readout electronics. The outcome of this effort will be a detector based on microchemical
with energy resolution capabilities. Targeted to be competitive with 3He tubes, NOVA will design and assemble prototype hardware and in
tor sensing materials for detecting the targeted small molecules gases, and a new generation of sensor array systems in plug-and-play mod

ms. In Phase I, we will implement the electron beam orbital dynamics and magnetic field designs. Design specifications for the Phase II smal
nificant advantages such as the capability to simultaneously measure fow rate and/or to distinguish nonuniformity in materials. The projec
e will develop a prototype for laboratory and field testing, and estimate its collection efficiency. The TSA can use this system to screen passe

contaminants in variable environmental conditions (fexible ConOps). Operation in infrared spectrum and the NLG packaging design hide t
d not only by the Coast Guard, Air Force, Navy, and Marines, but also has great commercial potential for law enforcement agencies and sur
m will have similar or superior capabilities, with micron thickness resolution, less than 1 mm lateral resolution and measurement times as fa

5% detection confidence, false positive rates are 1016 for 10 nM samples. Phase II focuses on 1) assay performance benchmarks for both

commercialize the technology throughout Phase II and beyond.

ecurity operations into a single system to minimize losses from the distributed threat of botnets. This technology is immediately applicable

ll as cognitive radio capability at the network layer for increasing link and overall network reliability. Both AES data encryption and two-way
d be a replacement for the NDG. Having already successfully commercialized a number of devices for the construction industry, TransTech is
ications protocol to reliably utilize Iridium satellite communications connectivity to a centralized biometrics database. The envisioned mobi

e country or going out to our forces abroad.

or adapting the AbioCor trileafet valve design to the requirements of a prosthetic replacement valve was the focus of the Phase I project. T

o take animals out and bring them back into the animal facility. Furthermore, the animal researchers can make measurements at will. ABQM
ing a suite of educational materials and support resources to address prevention and treatment of pressure ulcers. These are to be deliver

provements are expected to lower the cell-limited RNA sample requirement by 100-fold compared to current, commercially available kits. T
fit a wide variety of ultralight wheelchairs, 2) it meets of exceeds currently approved ANSI/RESNA wheelchair and seating standards, and 3
 the organization of graphs in a hierarchical index structure, and the mining of a set of graphs to find statistically over-represented motifs. T
easibility study of applying these new methods, called synthetic data, to a subset of the variables in the SSA records that link to the general
h the commercially viable and low cost manufacturing processes allowing real time ultrasound large aperture volumetric imaging to becom
s against light-induced stress. However, unlike animal studies that can only test a few compounds at a time, the goal of this SBIR project is t
stable primary mixed retinal cultures in vitro would allow screening and prioritization of further toxicity testing in a rapid and cost-effective
those that have lost hearing through disease or injury by developing a tool for research in cochlear implants as well as developing an impro
oject will develop a strategy for creating research supplements based on Medicare and Medicaid administrative files matched to several pr
files, and (ii) the Minimum Data Set (MDS)?which describes the circumstances of nursing home residents. MedRIC will carry out this effort
of unmodified carbohydrates and glycoprotein onto Au and semiconductor nanoparticles. The specific aims of the Phase I project are 1) to
Miniaturized microwave radiation energy will also be evaluated for quick and convenient immobilization of the polysaccharides on the prop

rated the technical feasibility of a prehensor designed specifically for children's daily activities. An adaptive digit was designed that provide
barrier permeability; 3) assessing oral bioavailability, pharmacokinetics and cerebral spinal fuid (CSF) levels in rats; and 4) synthesizing ade
involved in the donor cell isolation and purification process. The lack of a clear understanding of the manner in which specific parameters
cytotoxic activity. (2) Test blocking and inhibitory activity of compounds from a representative library of per-substituted beta -CD derivative
ogical tests and validated self-report inventories in an easy-to-administer set of protocols. Initial investigations revealed that AMP could be
ents treated with MAD, 2) document treatment efficacy using the Alertness and Memory Profiling (AMP) system, a highly sensitive and obje
threshold device (ITD), a novel technology invented by the sponsor to enhance negative intrathoracic pressure and augment cardiac prelo
fuorescence, and luminescence detection of the assays, a disposable lab-on-a-chip will be developed. Ultimately, a disposable lab-on-a-ch

in personal computing that should become as significant to self management as personal computers were a decade ago. Cell phones, whic
ts. Alzheimer's disease (AD) is an age-related and irreversible brain disorder that develops over a period of years. AD symptoms typically fir
rray of infectious pathogens. Given the special monitoring equipment and the technology required to support these children, caregivers ar
ble outcome analysis tool. Low back pain is a major socioeconomic problem in the industrialized world. In the United States, it is the secon
oxygen concentration. The acceleration and angular rate sensing information at each sensor location is transmitted to a handheld comput
he subject is in motion. Recent advances in IC technology enable AME to design and fabricate wireless EMG nodes that integrate the functi
bout 3.7 million Americans are visually disabled. Of these, 200,000 are blind, and the rest have low vision. The key advantage of the way-fi
. Ultra-wideband (UWB) is a fast emerging radio technology with the potential for major advances in wireless communications. The UWB s
val factor for breast cancer cells, 2) increased GP88 expression in breast cancer cells is associated with increased tumorigenicity, 3) GP88 m
cancer patients treated with growth factor and Akt inhibitors. The product would have utility in both a research and clinical laboratory setti
ease. As used to measure tumor-associated antibodies in serum from a cohort of cancer patients and risk-matched controls, this test afford

tched vector to eliminate sequence overlap between producer line and vector. The system is not compatible with most current clinical vec

y in combination with radiation therapy for malignant gliomas. Since this radio-gene therapy combination has not previously been studied
h by infrared absorption. In the Phase II program a dual, all thermoelectrically cooled system for detection of NO, CO2, CO and OCS in exha
hat use HFA-134a are 3-5 times more expensive than the old CFC inhalers, which is a big problem for some of the patients that need them
ot inexpensive to make by current methods. Fortunately, Aerophase has developed a streamlined extraction/reaction/separation scheme t
ibility of new methods to combine unstructured information from multiple public datasets to derive new insight on biological pathways un
a novel noninvasive automatic sleep restriction system for mice, an increasingly important species for studying sleep disorders. PSU has rec
. However, no standardized and automated touchscreen apparatuses for cognitive assays are commercially available. Here we propose to in
oped a generalized approach for engrafting therapeutic cells that makes use of target-specific modular bi-functional peptides termed interf
s the basis for engineering an antibiotic binding, peptide coating. The goal of this Phase I SBIR proposal is to validate an "Interfacial Biomate
ural materials due to the absence of osteoinductive and osteogenic properties. In this project, we are attempting to improve synthetic bone
phase I proposal, we will identify specific binding peptides for the multipotent subpopulation of cells in human bone marrow known as mes
determine an individual's baseline ambulation "footprint" and determine if there is any significant deviation from the individual's baseline r
s shown to bind fibroblast growth factor and promoted cell adherence in vitro. In periodontal regeneration, barrier membranes are an imp
core will be generated in vivo, intended to promote vascularity, proliferation, and differentiation for enhanced healing. In addition to being
e, learning experiences based on wirelessly connected handheld computers. For instance, in a K-12 course covering physiology, each group
and access requirements. The measurement system being proposed here will consist of the three parts: (1) the particulate matter sensor s
h laboratory in which it was developed to a small business for commercialization. Phase II activities will focus on InvTool and the process of

preserving analgesic actions. Specific aims include: (i) determining the relative selectivity of the neutral antagonist for peripheral vs. centr
s in the healthcare and clinical research enterprises via semantically harmonized domain models and standardized messaging interfaces. F
eal from implantation prior to expansion. For shaping the proposed expander should also be elastic and fexible. The properties to be optim
ase 1 milestones. The decision logic and results from the protein array will enable public health officials to rapidly identify infected persons
and assess infuenza sample preparation efficiency and efficacy in amended clinical samples. Success in Phase 1 will result in a Phase 2 pro
and computer control. ALA Scientific Instruments has developed controllable and highly accurate multi channel fuidic systems with this tec
st temporal response, but can only interrogate one well at a time. Radiation Monitoring Devices proposes to develop a detector system for
omplish this, we will integrate silicon-based CMOS (complementary metal oxide semiconductor) photon counting optical (GPD) detectors di
to produce as much as a three-fold increase in light yield over the known brightest scintillators, high X-ray absorption due to its high densit
ering cross-section of hydrogen and deuterium, neutrons make it possible to resolve hydrogen exchange processes that are well beyond th
ell tumor spreading. Similarly resistance to radiation and other treatments may become enhanced. Hence, it is necessary to monitor deep
call of nearly one million similar toys. There is no practical, cost effective method for testing consumer products for lead content. Existing te
ns that limit the ultimate grain sizes to below the wavelengths of visible light, thereby preventing virtually all scattering and rendering the m
g technique. The goal of the proposed effort is to design, build and implement new, solid-state photodetectors for reading out scintillation
this novel detector. The envisioned system will allow volumetric data acquisition in one second or less, while minimizing the radiation dos
uclear medicine with X-ray CT imaging provide better attenuation correction in cardiac imaging studies. It is clear that nuclear medicine tech
signals. The 'in-register' MR images may be used to compute scatter and attenuation in the PET images and also to estimate partial volume
ible. The detector is based on a novel, large-area scintillator, tailored for imaging thermal neutrons, coupled to a digital readout. This therm
e best reported performance is around 40% of the facts being found which we think is severely compromising the usefulness of text mining

analysis without compromising the cost per test. Successful completion of these studies will make available all of the technology needed fo
methods have been developed. Some of these new technologies have been adapted for large-scale automated testing of blood samples. W
convulsant (withdrawal) and anxiolytic properties that make it an ideal candidate for the treatment of AUDs. The cannabinoid class of com
ocess, structural and functional relationships of surface bound antimicrobials will be examined. Second, methods will be developed to ensu
distinguishing cystic from solid masses in which accuracy is 96-100%. Results suggest that more accurate application of ultrasound could he
. Designing a biological targeting vehicle that would deposit an a-emitter in the nucleus of a cell would be highly advantageous. To that end
uction of neutron generators produced years ago and are now being disposed of. Two sources have been obtained, totaling 1.5 Ci. Actinium
pathogens. As an analytical instrument company, AlphaSniffer realized the market's need of a label-free, real-time, robust and sensitive dia
he BS-LIVE-PRO onto discrete spots on a microarray surface using proprietary photocleavable linkers, and iii) methods to decode the rando
V-1 virus based on mass spectrometry of in vitro expressed proteins (MASSIVE-PRO). During Phase I, MASSIVE-PRO was developed and eva
based on mass spectrometry of in vitro expressed proteins (MASSIVE-PRO) was developed and evaluated for detection of chain truncating
mitations of conventional PTT, it is not practical for routine clinical use. Instead, current diagnosis is normally based on established non-gene
may be regulated by miRNA. Over the past few years, scientists have demonstrated that miRNAs play important roles in processes as diver
eir morphological and cytogenetic features, mutations that are undetectable at a chromosomal level have been shown to be correlated wit

overcome through the development and application of two novel classes of amphiphiles: two-headed "birosh" detergents and micelle-solu
cohol gel uses per patient day. We will claim that RHHP is feasible if hand hygiene compliance increases significantly, at the 5% level, from t
ll definitively determine the feasibility of using NORTECH as a treatment for gastroparesis. Up to 25% of the global diabetic population suff
ded by numerous logistical issues. Low molecular weight compounds that mimic the activity of SF/HGF could overcome these logistical diffi
hese drug candidates activate the SF/HGF/c-Met signaling cascade, and exert cytoprotective and anti-fibrotic effects in vitro. Preliminary da
has potential for the treatment of lung dysfunction, its feasibility is limited by issues relating to inherent instability of proteins in solution a
ce by blocking multiple events involved in disease progression. In previous work we identified a new class of c-Met antagonists (with lead co
l need for effective but affordable therapies. Recent studies have shown that Interferon-gamma (IFN) is a potential therapy for Scleroderma
ng the chronic architectural changes in the RA synovium via delivery of nutrients and infammatory cells, and to providing an important sou
uch therapies. The primary focus of research at Angion Biomedica is the development of small molecules that regulate HGF/SF/Met signalin

ly virulent variant of the facultative anaerobe Salmonella typhimurium, termed A1 that can grow under hypoxic or normoxic conditions. Th
ance studies by generating mutant infectious HCV viruses that harbor drug resistance mutations reported against experimental anti-HCV co
s have their own inherent commercial value. A more efficient bioprocess for human insulin can help meet growing demand. Diabetes is a gr
% and 100%, respectively, with the degree of dark adaptation impairment tracking disease severity. Finally, there is promising pilot data for
module. Direct application of PG to psoriatic skin should circumvent the signaling breakdown and help to inhibit epidermal hyperplasia. The
ss, even when compared to 1,25-dihydroxyvitamin D3, the active form of vitamin D hormone. Furthermore, preliminary in vivo studies sho
first method of SRBD diagnosis to meet these high standards, and (2) is capable of assessing the full range of SRBDs. In particular, the Sleep
use of the pivotal role of SK in regulating proliferation, we are developing SK inhibitors to be used as drugs to treat eye disease. In Phase I o
creatic islets as a therapeutic intervention for the treatment of Type 1 diabetes Given the important role played by Fas/FasL system in immu
tumor to evade the immune system. As such, to be effective tumor vaccines must be capable of generating a potent anti-tumor immune r
L chimeric with core streptavidin and is based on the company's platform technology ProtEx(tm), invented by the co-investigator of this app
and ERK5 pathways. Assuming the Phase I in vitro research validates our hypothesis that shRNA-loaded APMS both improves the uptake of
d during Phase I of this project demonstrated the successful implementation of the Detect-X(tm) technology in a proof-of-concept instrume
efficacy of the Web based training application. 1.) Encapsulate the knowledge-base required for safe administration of moderate sedation
pon the successful results in phase 1 and extend the display to include more variables to give the clinicians a holistic understanding of the p
critical aspects of anesthetic delivery and appropriate patient care. The display will be evaluated in both patient simulator and operating ro
und times; and (3) validate the resultant software using physiologically realistic test cases.
uroprotective effect without increased bleeding risk.
e patient outcome in terms of oxygenation improvement, reduction for duration of mechanical ventilation and hospital stay. Human apyrase
of nearby fying insects cause to incident light falling on a photocell. Insects are characterized on the basis of primary wing-beat frequency
nants is very important to the EPA in its Superfund monitoring activities, and the sheepshead minnow is an important species that is routin
nts to undergo chemo and/or radiation therapy. Our objective is to develop drug or combination drugs-eluting stent (DES) as a multi- moda
ment as a basis for developing a prototype interactive informed consent program for cardiac catheterization. This prototype will be e

ed containers with machine-readable tags for unambiguous identification. An automated precision dispenser which does not require pipett
ulk of biological, pharmacological, and clinical information remains available only in free-text form, and its volume continues to grow expon
tion by acquired host immune defenses and underlies the progressive decline in lung function. The alginate-specific human mAbs are both
nal fusion protein is produced with genetic engineering, wherein the missing recombinant enzyme is fused to a BBB molecular Trojan horse
- throughput discovery and clinical diagnostics. The ability to control the particles magnetically is a significant advantage. The technology h
The objectives of Phase II of this project are to build and test the CFM a-prototype. The CFM performance will be first assessed in colonosc
ed by current market technologies and has led to the presence of a plethora of drugs attempting to target neovascularization. Even if the e

clude a specialized mouse holder for securing the animal. For the robotic system to be able to perform these procedures, the animal must
Both in vitro and in vivo experiments are proposed in this Phase I application to optimize the hardware and software components of the ala
ce to analyze exposure to OP pesticides, assess the type and extent of OP agent exposure and then this information will guide the therapeu
IND submission. Aim 1: Determine that the anticipated clinical product, human MAPC processed under cGMP conditions, exhibits therape
eral administration is required for buprenorphine, a process that is inherently stressful to the animals. In order to reduce the frequency of h

d region so that the complement of the void region is created. Then ligase is used to connect this extension product to the other probe, cre
 . The inter-subject variability increases the variance associated with threshold measures. The poor comfort limits the time that some patie
of action. Moreover, the overall market for antibacterial drugs is large and growing - world-wide sales are projected to reach $30 billion in 2
have experience in all aspects of the drug development process, from concept to approval and marketing. The successful completion of th
elivery formulation for cyclosporine that proved useful in clinical trials in posterior uveitis, a preliminary subcutaneous formulations of cyclo
cs and the duration of the formulations in rats. The successful completion of these goals is described in the Phase 1 report. We successfully
ulmonary fibrosis. We recently developed a class of synthetic TGF-a peptide antagonists (termed TGF-a peptantagonists) that antagonize TG
al trial. In other ongoing clinical trials we are beginning to demonstrate the efficacy of this diagnostic imaging agent, however additional va
etwork, an F version of DTBZ would represent an incredibly 18 powerful and widely accessible tool for the study of diabetes. We have now
A large animal model would allow larger gaps to be created and incorporate long regeneration distances that would more closely model the
ucing their effectiveness in killing cancer cells. Axona has identified a small molecule calpain inhibitor, AK295, which prevents axonal degen
erified genotypically and phenotypically. Specific Aim 2 :- Construction of rBCG with altered immunostimulatory properties - The objective o
pment of ultra-sensitive brain injury biomarker diagnostic assays. We have the commitment to providing such a tool to the marketplace, ba
ons, and significant R2 values) based on an n-fold cross-validation technique. Additionally, inter-instrument correlations will be computed a
s important for ob- taining valid estimates of behavior and neurological status, documenting recovery from acute effects, predicting subseq
will be performed. The MIRT analyses will result in a calibrated bank of pain assessment items that will be utilized by the CAT-driven KnowPa

prolonged times to ensure sterility. The proposed biological indicator should perform as the conventional indicators because both depend o

t hardware speeds, with an innovative architecture that ties the comparison logic closely to an array of hard disks, guaranteeing massive da
vious 2 weeks). Phase II goals include: revisions of the Windows and web applications based on feedback from the pilot study and expert p
ocuses on: 1) building and maintaining motivation for change; 2) dealing with urges; 3) problem solving; and 4) lifestyle balance (balancing
s will determine the standardized version of the HSI-A. The six objectives of this study of Hispanic early (13-15 years) and late adolescents (
3) Conduct a feasibility pilot study (n=30) using a randomized controlled trial to evaluate gains in knowledge of BA, recall of BA component
eatment with adolescents. Specifically, the initial aims of this Phase I proposal are to: 1) Determine content for the prototype utilizing an ad
elopment of an ADP detection assay, a highly specific monoclonal antibody and fuorescent tracer will be developed for detection of GDP. T
ence in the molecular analysis of leukocyte chemotaxis. In preliminary studies, Dr. David Beebe - a scientific founder of Salus Discovery - and
onolayers of cells. In Phase I, we developed a prototype microfuidic device and used it to extend a well established model of mammary ep
is in place, we will then transition into phase II study to screen for proteins or molecules that could be used to expand the number of prog
of Bexion's treatment agent on (1) orthotopic and (2) metastasized prostate tumors in male athymic mice. To achieve these objectives, we

r and energetically impaired adults. Despite the advantages and need for such a regimen, no commercial system exists that has the fexibili
he value of pigs to human health research. The reduction of stress associated with elimination of restraints or handling, should also improv

ket more than 150 different enzymes formulated as active lyophilized powders, including transaminases, ketoreductases, nitrilases, amino a
we found that the hand-held BFI detected an electric field averaging 696 mV/mm at the borders of three of the four malignant lesions in t
with minimally-invasive MR-guided needle biopsy. This is a new venture of Blake Larson and Dr. J. Thomas Vaughan of Bioengineering, Inc.,
g molecular targets. In addition to completion of a compelling software tool for life scientists, the collection of appropriate data before, du
condary mutation in EGFR (T790M), accounts 50% of the cases of resistance. Given that other EGFR inhibitors may be effective treatments
we will evaluate the replication fidelity of the pWGA technology using genetic selection methods. The leading competitor for pWGA is mul
ow filtration, high variability, and require the use of centrifuges which is cumbersome and not compatible with the robotic sample handling
man disease and/or biodefense considerations. The genera we will focus on include agents of lung, cutaneous, and tissue infections (Myco
es of a very high frequency and broad spectrum (1-4 GHz). The resultant echoes are collected by extremely high-speed circuitry and analyz
M-1) and intercellular adhesion molecule-1 (ICAM-1) and of a nitroso pyrimidyl substance (EC-234) that acts as a nitric oxide donor. Our hy
e matrix over damaged, lacerated tissue following abdominal or other intracavitary trauma. In preliminary studies, it was demonstrated th
e specific aims of this project will build on a firm foundation of STIS technology and include (a) Conducting a requirements analysis to identi
the causes underlying observed geographic and racial disparities in cancer incidence, mortality and survival, and (2) long-term quantificati
trol study of bladder cancer in south eastern Michigan, and to identify local excesses of breast cancer in Marin County, California. Because h
oping technologies that assist physicians to more effectively treat the glaucoma patient. This is inline with the mission of the National Eye I
ting technology developed under Prof Sturm at Princeton University with BioNanomatrix's nanofuidic DNA analysis technology. A micro/na
roughput production of high quality antibodies at a lower cost. Specific aims for Phase I: (1) Screen a series of proteins to identify new high
serologic assays. However, in combination they could provide the basis for a much improved assay. Linear epitopes have been identified in
tibodies cleared B. burgdorferi from the tick vector. Thus, this bait vaccine is a good candidate to break the enzootic cycle of this pathogen
have limited diagnostic value over methods that directly measured GFR using an ideal filtration marker, such as inulin. This Phase I applicatio
types. IVST will allow researchers to conduct analyses on cell therapy protocols not readily feasible previously and to obtain badly needed
inium oxide colloid is stable in an aqueous suspension under a variety of challenges, including autoclaving, and demonstrates that this rea
y due to the lack of a sensitive and specific assay to detect soluble TL1A. This prompted us to report a prototype immunoassay to demonst
e-I STTR study. First, we propose to develop a high quality soluble recombinant human DcR3 (rhDcR3) so that the protein can be safe and e
igns. The resulting systems are bulky and limit the range of potential subjects to cooperative humans who can sit upright and fixate well for
d, easy-to-use, automatable sample preparation, inexpensive, rugged with low-power consumption. We have successfully completed the s
will be comprised of synthetic DNA encoding one to six modules of the DEBS polyketide synthase, the megaenzyme that catalyzes the biosy
e.g. proteolysis of peptide substrate), or hydrolysis of a substrate-fuorophore conjugate (e.g. galactose removal from fuorescein-digalactos
erface for remote configuration of the on-subject transmitter; 2) make previously impossible recordings of wideband signals during movem
t can transform speech spoken by a "source" speaker into speech that is perceived as spoken by a specific "target" speaker. To tune the tran
indicate that the lumen/stool microfora may be indicative of the disease state. Our goal is to determine the feasibility of monitoring dysbi

address the unique cultural niche central to African American life. Humor, appeal to family unity, struggles of urban life, and celebration of
ted dry power aerosols at a concentration of 5 mg/l. This Phase II we will optimize, construct and test an alpha prototype of SUPRAER(tm),
ously sequenced without the a priori design of sequence specific nucleic acid probes. Furthermore, the assay is more rapid than nucleic aci
to advance our fuorescence sensor, in preparation for preliminary human trials subsequent to completion of Phase II. To accomplish this c
ITC, Alexa 488, Rhodamine, Texas-red conjugates for immunostaining. Apoptosis or programmed cell death is a distinct, intrinsic cell de
s the appropriate ion channels in functional states): the cell of interest must form a high-resistance seal with the planar substrate, the who
day use, but easy to access when necessary. In Phase I, we developed and evaluated a working prototype and received enthusiastic feedbac
gical navigation will improve the accuracy of glenoid placement. Specific Aim 1 - Develop proof of concept preoperative planner for TSA all
ulating half-life of interferon gamma. During the Phase II, we will perform more extensive PK studies that evaluate different modes of admi
VEGF Receptor I (also known as sFlt-1) to rationally design polyethylene glycol (PEG)-sFlt-1 conjugates using cysteine-reactive PEGs. We int
-stroke MEMS deformable mirror will be combined with the optical doubler demonstrated in the Phase I effort to achieve an effective defo
phase of steady- state tidal breathing (Carboximetry(r)) will accurately discriminate patients with PE from patients who have other conditio
urfaces. These deposits inhibit drainage; are virulent bacterial reservoirs; and increase susceptibility of the local tissues to infection. Antibio
commensal microbial community could be established. This "healthy plaque" would then serve as an effective barrier to prevent the subse

pment of technologies that will permit observations of unaltered small molecules which are quantitative and made in real time. Real time
med in individual patients may be correlated to genetic differences regulating metallothionein or other metallome proteins thought to be r
aporator, vacuum lines for reactions and distillations, atmosphere controlled glove boxes, heating/stirring mantles, spectrometers (UV-VIS-
as potential therapeutic candidates for ALS. This project is a collaboration between Cambria Biosciences and the laboratory of Rick Morimo
anscriptionally activate DJ-1 both in vitro and in vivo. We will build on this promising experimental foundation to identify potential therape

ssessment of hydration status in the hospital, doctor's office, long-term care/assisted living facility, or the home setting. The company has c

erm self-renewal and the fullest multi-lineage potential. The mission in Phase II is to obtain essential pre-clinical data-using the human CPC
 tics has developed a methodology for surface-modifying PLGA nanoparticles, enabling not only the addition of sufficient surface PEG group
h patients' clinical outcomes for various clinical situations. In Phase II validation study of our proof-of-concept prototype cerebral oximete
DVDs that will demonstrate motivational interviewing techniques with college students (DVD 1) and model both the assessment and feedb
s been associated with an improvement in cognition, regarded as the true sign of improvement in AD, our study did not address either the
clusters of progenitor cells from adult human pancreas; 2) Assessment of the differentiation potential of human endocrine progenitor cell
cessing. It is the intent of these studies to provide a better understanding of the unique responses of hLC to ex vivo manipulation and utiliz
pment of the system are as follows: (1) The CryoInject(tm) will be a hand held device allowing for ease of application; (2) It will incorporate
lTM will be applied directly to the NVB at the time of the cryosurgical application; (2) The protective agents will be designed through mole
s an immunoprecipitation reagent and that best recognizes acetylated-lysine peptides in a sequence-independent manner. After choosing

of data and to update the interfaces so that users can view and compare sets of phosphorylation sites associated with specific cancers and o
o continue the awarded Phase I project (1R43CA117178-01A1) under program announcement PA-04-161 "Manufacturing Processes of Me
of next- generation HTS technology for the simultaneous screening of millions of peptide compounds for biological activity with pooled ph
ractable gene families that are amenable to small molecule drug discovery research. In collaboration with our biology consultants at the Fr
domains a genome-wide database of functionally validated (FV) shRNAs with minimum off-target effects and software for prediction of effe
dendritic cells, erythrocytes and platelets. We have refined ex-vivo culture conditions resulting in the successful expansion and cryopreser
e, and gel filtration method, which is commonly used in developing countries because of low cost but generates vaccines that are highly co
uction of real-time PCR have considerably simplified viral load testing. However, preparation of nucleic acids from serum or plasma samples
d or propagated in culture. Cellular Dynamics Intl. Inc. (CDI) will develop human embryonic stem cell-derived cardiomyocytes (hESC-CMs) to
gh false positive rate due to human error, and Ineffective against counterfeit drugs. The PVS will utilize a new generation of Raman spectro
adaptable to portable, point-of-care diagnostic applications. This unique Raman spectroscopy engine is ideally suited to exploit the many f
s inherently better imaging due to the superior properties of the piezoelectric single crystal. During Phase I, TRS will establish deep etching
wide bandwidth. In the Phase I program, a single element transducer was constructed that exhibited 80% bandwidth with one acoustic mat
on methodologies. The studies proposed in this application are designed to assess the utility of Centrose's patented technology, known as
biological activity. They exhibit a >18-fold safer therapeutic index than digitoxin, based on their much weaker inhibition of the human Na/
tructed in a previous study that demonstrated the feasibility of 24h perfusion preservation at 2-7 degrees C using a porcine model. This exc
new system could be used in the clinical laboratory or directly in doctor's offices, creating a large new market opportunity. Applying the te
develop an anti- EA robotic assay that would be valid (i.e., reliable, accurate, versatile, rapid, and cost effective) using MCF-7 cells. In this Ph
a water-soluble prodrug of CA4, has both anti-proliferative and anti-angiogenic activities. CA4P also showed potential inhibition of retinal N
nd that invests in pharmaceutical companies and has offices in the Silicon Valley, Boston, and OKC. Additionally, the company has a strong
ular disorders is limited due to their weak anti-angiogenic activities. Recently, we have designed and synthesized a series of novel thalidom
monary hemorrhage. The major obstacle to successful treatment is the difficulty in making an early and accurate diagnosis. The goal of the
type of microarray. This project will utilize two main thrusts to achieve these goals: 1) a new label-free, electrochemical-based hybridizatio
argeting foreign ACCs. We have developed and tested a high throughput protocol necessary to screen large chemical libraries. We also prop
he functionalized fibers, and 3) to evaluate and refine the fiber adsorbent for As removal. If this Phase I program is successful, a Phase II pro
ery in asymptomatic pregnant women. Our long- term goal is to use these biomarkers to develop a clinical test that would serve as the earl
t (AABCP). When completed, this research will create a low-cost, easily-distributed, and replicable method for training in cultural competen
olecular labels. The system will enable assessment of patients' immune capacity in near-real time using microliter-scaled samples of blood r
ation, and prognosis, assessment of therapy and monitoring of recurrence, in the treatment of autoimmune disease. This, in turn, should le
pecific CD4+ and CD8+ T cells capable of testing thousands of targets simultaneously using as little as 2ml of patient sample. The proposed

dure more convenient for patients and the medical community.

ding motor function, olfaction, heart rate variability and electromyography during sleep, voice modulation, and oculomotor activity. The pro
king. Rational CNS drug design cannot entirely and exclusively rely upon the physical-chemical properties of putative neurotherapeutics, sin
ed in Phase I and is available online at DementiaCareCentral.com. When completed, the site will provide dementia caregivers with online,
iology risk factors module very high - 8.5 on a 10-point scale and were very satisfied with the module. As pointed out by one of our experts
4 and related compounds will be assessed. Specific aims include: 1) Synthesis and pharmacological evaluation of novel muscarinic agonists
cursor (AaPP) in brain, designated Tg-SwDI, that develop early-onset and extensive fibrillar cerebral microvascular Aa deposition in the abse
colitis, measure the response to treatment with different doses of COG112 using clinical outcome measures, histological outcome measur
aracterize genetic factors that infuence the disease progression and incidence. The protein apolipoprotein E (ApoE) provides a convergence
igation-perforation model. In order to further pursue COG133 as a treatment for sepsis, we propose to complete evaluation of COG133 in m
fferentiation and survival during immune attack, infammation, excitotoxicity, and oxidative stress. Cognosci, Inc. has innovatively designed
00% remission rate in EAE. This Phase II proposal will capitalize on the success of our previous work to examine the mechanism and relative
t is that Cohera's proprietary biocompatible polyurethane tissue adhesive can be engineered into a viscous formulation for ease of delivery
esive strength. Accommodating the physical constraints required to deliver a viscous fuid by spray in the operating room environment will
ost, and physical independence of the vaccine antigen, suggest that they might be ideal adjuvants for enhancing the protection afforded by
ssing skills at the syllable level and then gradually introduce demands for top-down processing in connected speech. In Phase I, speech per

rade ethanol and stabilizing industrial esters. With many opportunities, a large number of industrial and pharmaceutical companies as well

of these compounds as hypoglycemic agents. To accomplish this goal, we will synthesize novel puerarin analogs and screen them for their a

assessment of patients with bilateral CIs of all types; however, an assessment protocol for monolateral implants of all types will also be de
be present in high concentrations. The novelty lies in the fact that the exhaled breath will be introduced into the vacuum system, housing t
nging from 3% to 37% (e.g., Von Korff, Deworkin, & Le Resche, 1990). However, a conservative estimate would place the number of America
theory that both captures the important physical behavior of highly charged biomolecules (e.g., volume exclusion, finite ion size, image effe
hat the laser solder approach is superior to standard sutures with no evidence of tissue shrinkage. The strength of the soldered repair was d
core competencies of our team, can be used in conjunction with a single photodiode detector to manufacture an ultra-compact and inexp
also have a limited distraction distance, producing short segments of straight bone and so cannot accommodate large deficits with a single

pilot test with a sample of disabled older adults. The product in Phase I will be a prototype version of a LLFDI-CAT. In Phase II of the resea
to new facilities, and appropriate for short or long- term use. Two design concepts for the stabilizer component will be evaluated in Phase
atistical and econometric models that have never been applied in this space. These models will: 1) Improve specificity through customizatio
successful implementation would lead to a viable commercial product, which would meet a clinically relevant need and build upon existing

emoglobin fraction accurately. A noninvasive and reliable methemoglobin sensor will have great impact on therapeutic decision time. The

onstrate significantly improved specific antibody secretion rates from LEAP-derived clones, along with an acceleration of the process, as co

ture device. Maturation and growth of the engineered tissue will be monitored by non-destructive MRI and biomechanical testing, and fun
T lymphocytes that recognize the melanoma antigens Melan-A/MART-1 and gp100 as they are presented by HLA-A2 in A375 cells. For the
sage, route of administration, bioavailability, solubility, stability and metabolism) as well as define structure activity relationships by screeni
possess properties consistent with potential in vascular cell therapy. These studies will include evaluation of cells similar to EPCs that are c
ent a knowledge-based approach to fundamental problems in human health and disease. This proposal seeks to continue the developmen
s. Using a modular design, STRIVE will be created for use by professionals or paraprofessionals in advocacy organizations or schools. An inno
with modules for both counselors and clients, including didactic and interactive elements. The goals of the confict resolution package are t
develop, evaluate, and promote a multicomponent Trichotillomania Referral Awareness and Treatment (TREAT) program. The fundamental
a Web-based training program, including scripted telephone triage and initial interview processes and a pocket guide, will help to "re-orien

s 13 to 18 and their families. This developmentally appropriate and culturally sensitive program will contain a facilitator's guide that will inc
 ethods for continuous and discrete outcomes of the above nature. In this area, typically, people apply generalized linear mixed-effects mod

30% not doing any prescribed treatments). CF can cause a host of social-emotional stressors, including uncertainty about the future, poor
rease in their sense of empowerment in dealing with BPD; (3) a reduction in their subjective burden; and (4) a greater sense of hopefulness
SC will cover the effects of alcohol on the brain and body, decision making, relationships, and risky sexual behaviors in a biologically and dev
nd BACPTDP are novel camptothecins that were originally designed at Duke University to be used in the treatment of childhood neuroblast

disorders of demented individuals into information that can be readily used by a caregiver. An Interactive Training Module: Sleep Behavior
ll Area Demographic Estimates for China, will determine feasibility and test methodologies to update the People's Republic of China 2000 C
MIS. The long term goal is to produce a commercially available unified surgical instrument system for performing MIS. This system will allow
eb-based RBS training program addressing these several public health needs, targeting college and university hosts readily accessible throu
mmunication with patient's suffering from these disorders as well as the development of practice protocol, have been identified as barriers
mising candidates will then be evaluated as orally available drugs against malaria in mice. Once these experiments demonstrate the feasibili
HRS data, the system will produce preliminary samples of localized reports on the older population, including key characteristics and descri
-clinical studies will be presented to the FDA for an Investigational Device Exemption (IDE) application that, when approved, will allow the D
ppropriate patient plasma samples to enable novel protein isolation and identification, novel affinity reagent creation, assay formulation, a
of biomarker discovery and also simultaneously provide affinity reagents for those biomarkers. These affinity reagents will immediately be
dication details directly from the pharmacy. The software system will be refined through usability studies. A powered clinical study will be p
ver eight weeks, the SPIMA index will be validated. The objective of that study will be to establish the overall feasibility of SPIMA to predict
e EA and ProLabel fragments into a protein kinase and its allosteric regulator protein. When the kinase and its partner interact, EA and ProL
y. We have begun to adapt EFC to measure the interaction of different growth factor receptor subunits. The spontaneous, robust complem
ether (LTT) vector system to increase uptake of SB transposons into liver cells. This aim will be accomplished by construction of a LTT targeti
deficient in Fanconi anemia complementation group C (FANC-C) by SB-mediated transposition. In this Phase II application, the overall goal i

o the dosimeter, and also strives to enhance user-acceptance with the novel integration of the hardware into a 'smart' safety cap. The safe
develop new compounds with 'macrofilaricidal' activity that are desperately needed to complement the current regimens. During Phase I
ogy specimens. The long-term goal is to image slide-borne specimens in less than 60 seconds at 0.23-fm sampling (i.e., equivalent to a 40X
hybridization stringency. For several reasons, the BLAST algorithm fails to identify many candidates for mis-hybridization, representing pote
acquisition, analysis and report presentation. B. Further develop our scanning technology by improving the hardware, especially the optics
ling cross-polarization, de- coupling, indirect, and C hyperpolarization methods for even greater gains in S/N and spectral resolution in 13 M
ution, along with dramatically reduced rf sample heating, in triple-resonance 1H/13C/15N probes. This proposal seeks funding to begin the
es used in Nuclear Magnetic Resonance spectroscopy that will cumulatively improve sample throughput efficiency and expand experiment
c iodide films. We expect to widely market the device as an OEM component to Dental radiography manufacturers. In Phase I of the projec
r a time, photon counting is used to measure and count each x-ray individually over a similar time. By doing this, the following additional fe

PF analysis decomposes complex BP and BFV signals into empirical modes, representing their instantaneous frequency-amplitude modulati
coli heterologous hosts into environmental DNA screening schemes. Aim 2 will then test for advanced antibiotic screening success based u
nd tool life only achieve limited success; suffer from high cost and complicated setup; and need additional equipment. The chemical reactiv
ide, BCA during infancy has the potential to become an important research and diagnostic tool for the study and prevention of child and ad
thogenic bacteria that was developed at ECI Biotech. This method measures the activity of protein-degrading enzymes (proteases) that infe

otoxin sensors for rapid field assays. This Phase I research will be performed with three specific aims: (1) Apply in vitro selection to identify
eriodontitis is mediated in part by host- and microbe-derived protein- degrading enzymes called proteases. The long-term goal of this prop
er regulation of baculovirus promoter (bv) in insect cells, insect cells cannot grow as fast as E. coli and have other drawbacks for commerci
mixtures of osmolytes. This system can successfully fold 1) aggregation prone proteins, 2) insoluble proteins isolated from inclusion bodies
ograms, revisions to each program will be made based on findings of the feasibility studies. Once revisions are completed, full-blown field t
e, the inventors of the new suspended membrane configuration, and Professor David Deamer, a pioneer in the science of DNA translocation
ect many short duration single channel events seen in many channels such as the Na channel. The proposed project aims to further develo
e school and introductory biology students that personally impact students' daily lives; these products will also be specifically designed for
. The sensors would also measure pesticide metabolites in urine, providing the NIH with more data on the daily exposure/daily ingestion of
ed with each MRA. The arrays can be made in microscope slide format for compatibility with commercial microarray readers. In the propos

tively between areas of infarct and viable islets in the infarct areas would be useful for clinical decision making. The objective of Phase I wa
fying outcomes over a period of approximately one year. We will conduct studies to evaluate further the necessary training and backgroun
00 antibiotics, with the result that it is now very difficult to isolate an organism or compound that has not been encountered before. Howe

s of the research to practice technology by consciously synthesizing research findings and professional material that provides detailed desc
extracting and transferring relevant data from available public archives, b) organizing extracted data in data sets ready for analysis, c) produ
able, users have very limited control of the way their message sounds. Thus, misunderstandings result and the AAC user becomes frustrate
destructive evaluation of approximately 80% of the tumor margin in the excised specimen (as opposed to 1% provided by touch prep or fro
ydrogel, without the limitations of the liquid embolic agents currently available, for AVM filling. The hydrogel will provide performance ben
racteristics have to be greatly improved before they can be acceptable universally by clinicians. The goal of this project is to develop a bioco
soft x-ray microscope. In Phase I Energetiq explored the capability of the light source in the "water window" range of wavelengths and det

or chemical assays will be carried out and the results detected. Enertechnix, Inc. will be responsible for adapting its existing aerosol concent
e performance of the instrument will be characterized in the lab for the effects of real sample issues, including several classes of interferen

ntal tasks they are thought to perform and how drugs of abuse can affect performance of these tasks. They will also be able to test their ow
ood group antigens. HDN has been treated successfully with Rh immune globulin since the 1960's. The success of the treatment, though, h

mplementation to measure average respiratory resistance, as well as separate inspiratory and expiratory values, in nearly 1,500 people. The
bit leukemia inhibitory (LIF) factor and derive putative rbES cells. We hypothesize that using feeder layers and LIF from rabbit origin will incr
ying both high potency for PK inhibition and selectivity against other enzymes in the intrinsic pathways. In addition, sensitive plasma-based
r which a mass innoculation campaign is impractical or inappropriate. Peptides are of particular interest for targeting intracellular drug targ
This technology will allow for therapeutically relevant delivery in small volume spaces, such as intracranially, where dose escalation by volu
n may also have beneficial anti-infammatory effects. The major achievement of Phase I was demonstrating that the effects of lacritin obse
on. The specific aims of this application are to; i) demonstrate the application of the EpiTagTM technology for the detection of splice varian
nmental variables, and can be executed and interpreted by unskilled personnel. We suggest that an accurate CD4+ counting assay with the
y means of a prime-boost vaccination strategy, we will optimize key vaccination parameters (administration route, antigen targeting, adjuva
I contains highly immunogenic T- cell epitopes that are excellent targets for mutation in order to prevent T cell-dependent antibody formati
oice for many applications analysis time is a critical consideration. The proposed system can be used to directly measure enantiomeric exce
necessary. The applicants have constructed a mini-GC modified to detect ethanol in a real-time manner with excellent specificity that can a
recognized as safe" (GRAS) compounds as taggants. The "taggants" can be applied as a coating to the medication, be added along with the
sed by macrophage foam cells found in atherosclerotic lesions and thus be used as superior MRI contrast agents for plaque formation in pa
essed Akt2 and activity of the endogenous Akt. The assays will be developed for use with 96-well streptavidin-coated microplates to immo
lls can be culture-expanded and 're-differentiated' into lipid-synthesizing and storing adipocytes. This work, along with a previously publish

. These findings will enable the development of a diagnostic ELISA serum test for human cancer based on phosphorylated FAS which would
wledge is revealed that can lead to further optimization of the technology and extension of the technology to other industrial fermentation
mportant information and technology that can be used to rationally engineer Actinomycetes for rapid commercial development of critically
njugated bilirubin and bilirubin isomers produced during phototherapy, and (3) optimize the assay for clinical use through improvements in
 (FSR) is a biotech company located in Charleston, South Carolina. The founders of FSR, Drs. Robert Gourdie and Gautam Ghatnekar are co
ut discrimination by the probe as if it were a short oligonucleotide. This platform technology should have application in many assays, includ
yed Imaging Refectometery (AIR) biosensing platform to build a device capable of capturing the detailed physiological response to PM exp

(2) The company will then collect data to model nurse-patient interactions by recording actual nurse-patient interactions in the hospital an
drocytes in the extracellular matrix over the entire growth process. Specific Aim 1 is to track the activity of GFP that serves as a marker of c
drate synthesis. Using a commercially available solution-phase synthesizer, automated fuorous-based carbohydrate synthesis protocols will
hannel recordings via patch clamp measurements and (3) intracellular delivery of short interfering RNA (siRNA) for target identification and
SP and ESSP assessment tools and practice resources; (b) development of advanced website features, and (c) a 1-year experimental test of
lant's power supply will be self- contained, with a transceiver capable of sending and receiving external commands. In its final form the imp
tify genes whose homozygous perturbation leads to the ability of host cells to resist infuenza infection. In this current SBIR Phase I propos
sease diagnostics such as detection of cancer, large numbers of RF coils are required. While as many as 128 receiver-channel coils have bee
uch neurodegenerative diseases as Alzheimer's disease. Given the discrepancy between reports in the literature as to whether androgens a
compounds are triple re-uptake inhibitors. The proposed preclinical studies will be done on 3 pairs of enantiomers, which we have resolved
for effective situation awareness and threat analysis. Phase II will yield a more mature and more sophisticated environment with more effi
nd unique elastic properties. These unit-cell analyses will guide the design of manufacturable composites. Finally, our proposed work inclu

erial, to replace the existing Tonpilz design. Key performance metrics will be compared with existing data to highlight improvements availab
val, military, and civilian engines.
philosophy based on COTS hardware components in the industry standard ATCA form factor. Software development tools used for this proj
generate a damage data base that will be incorporated into a fast running damage response model. The model will be validated against firs
ansceivers utilizing the proposed new waveform type. Like the dynamic waveform itself, the AIDL transceiver signal processing is governed
ficate distribution and policy management will be built into an architecture-based environment supporting persistence and reuse for analys

we will develop a detailed design concept for implementation of the BRDA system for an AUV.

networking protocols. A multi-modal optimization technique is proposed to accommodate ingress and egress node parameters within a fra
anguage (UML). The effort proposed here would demonstrate development of modeling algorithms for an example weapon control applica

of previous work including ontology creation, ANOVA analysis, neural network generation and automated network control, toward the spec

ftware-reconfigurable modem and reconfigurable radio frequency (RF) front-end as well as a low-power processor that interfaces with the t

ed by higher level processing to determine the target’s location. This capability can also be used to disregard false alarms from unrestricted

se to a “deployed” configuration as possible. Actual construction and demonstration of the preliminary design will be undertaken in a follo

e emerging and future SDR standards (e.g. the Object Management Group’s (OMG) SW Radio standard).
acecraft testing and checkout for a variety of potential intelligence, surveillance, reconnaissance, and communications related R&D projects
ed so far ------ automatically adjusting the transparency of display screen to adapt to environmental brightness.
model checking, simulation, Markov models, Petri Nets, SANs (and more) and is open to integration with third party tools.
model based analysis for system safety and dependability properties provides a solid foundation for our approach, enables the consideratio
d improving performance certification efforts. They also improve risk management by identifying and tracking issues as early as possible an

OM planning and operation.

o be used for the SATCOM design and the bandwidth performance evaluation, and the OPNET simulation model to be used to evaluate the
ght pollution from the sun’s direct beam would otherwise render radiance CCD imaging impossible. The R&D of this sensor suite involves bo
a surface temperature to low earth-orbiting data satellites. Near real time data will feed sounding data to the Fleet Numerical Prediction ce

this research as part of a Phase 1 and Phase 1 Option with the Phase 2 effort ultimately resulting in the delivery of vastly improved batterie
ce of GPS. Because the proposed SBIR solution can be built around an existing Yotta solution platform and architecture, a field-testable pr
tifiable performance results. The approach will also permit significant time for testing, optimizations and enhancements during Phase II. T
ery of the ocean surface; and to determine optimal parameters of the airborne/spaceborne microwave sensors. In case of positive results o

the feasibility to achieve these goals by mechanical (ANSYS) and optical (ZEMAX) simulations and a demo of the principle.
AERO. Based on the computed CEFM results, a useful free-play scaling law will be developed that can be readily applied to establish improv
ng nonlinear system identification) to solve for nonlinear aeroelastic responses under continuous wing morphing. Finally, NANSI.AE along w
evented. The key of our new design to solve these problems is to put a sensor between the front tire and rear tire without defection and p

esearch team at the Georgia Institute of Technology, resulting in a proof-of-concept model and manufacture-ready drawings for a prototyp
ossible of this manufacturing technology to MDA platforms.
nd warm-up.

ese results will become the baseline research for a transition into a Phase II contract. With the effective modeling and simulation approac
elopment of a Navy-Relevant Polarimetric Database, and (e) Development of a Portable Prototype for the PLADAR and Performing Field Te

etric studies to optimize passivation techniques for BAE’s process fow. Hydrogenated/non-hydrogenated (striped) hybridized arrays will be

o motion sickness susceptibility. This could result in a simple, safe method to determine an appropriate individualized training regimen.

orn. The adaptation is a natural result of the material properties, so is done passively and in real time. The materials are lightweight, breat

valuation.

omplete system design and partnering for manufacture and delivery.

roved, and a prototype will be constructed, analyzed, tested, and evaluated.
cted cells (CICs) fabricated with the SEHB technology will be delivered to AFRL or platform manufacturers for prequalification. Infoscitex has

ging scene; however, the data extracted from each of the subapertures could be combined to get a better understanding of the dynamics o
r communications antenna embedded in a structural composite.
 Option portion of the workscope will seek on-engine / spin-cell opportunities to demonstrate the software system.
itary, that is both realistic and achievable in the scope of Phase II.

provide real-time feedback to the trainee as to the efficacy of their AGSM.

tensive testing, and develop a UV-luminescent underlayer to facilitate non-intrusive inspection. Our team includes experts in coating depo
n tasks will be to evaluate the representative sensor platform containing our EAP propulsion and energy harvesting systems in a water envir

essments using organic assets, and will support broad elements of the SSTR mission set, to include the Department of State’s Coordinator f
ddition, the application of ionic liquid based electrolytes in the Lithium-oxygen battery technology will be explored. Furthermore, we will m
gy into deployable systems.
ystem, fabricate prototypes, and perform a detailed simulation of the device under realistic operating conditions.

thermal performance and CTE matching to the T/R module.

l and oral formulations of Indomethacin-PC will be optimized by the scientists at PLx Pharma in close consultation with our industrial adviso

This pilot material will be validated by the Army through chamber testing.

PhC designs and fabrications will be realized by UPenn while nanoparticle dopings, polymer waveguide mode transformer integration, EO m
ther gas turbine engines.
biodetector applications in a miniature package with minimal logistics burden. A critical need exists for a universal sample preparation met
oftware systems approach. This approach features cutting edge, Field Programmable Gate Array (FPGA) high-performance computing on m
the plasmoid formation and acceleration has been demonstrated, and this work will extend these results to produce a multi-megawatt thru
eveloped NLO polymers with exceptional nonlinear index changes. Nonlinear scattering devices will take advantage of newly developed te

will lead to cost effective enhancements to the C2BMC situational awareness for the warfighter on the nature of actual missile threat being

e investments made by DARPA; U.S. Army ARDEC and ARL; AFRL Sensors, Space Vehicles Directorate, and Information Directorate; and JPEO
l properties will be evaluated to ensure suitability of this procedure for IBRs.

eted by standoff kinetic missile engagement to determine the resultant engagement lethality. This will allow rapid screening, developmen
ulations for Phase II development.

o support automating the construction of analysis model geometry topology for mesh generation. Structured and unstructured meshes (1

ng the pedestrian detection algorithm onboard a tactical UGV platform without significant sensor or hardware modifications; and evaluatin
miniature inertia based igniters for thermal batteries should satisfy the need for the development of low cost, safe, very small and low pow

solutions using physical experiments comparing the performance against current handoff schemes. In conclusion, our work represents the
to provide tracking/in-transit visibility (ITV) of less than pallet/case quantity medical shipments from the point of origin, or from an interme

approximately 150 words) The proposed rotary percussive coring tool (RPCT) could contribute directly to several NASA missions planned
biomass sources of energy from non-energy materials, properly manipulate and ingest the biomass materials into the engine system, and g

unding is secured for Phase III.

ment, and should readily satisfy the need for the development of low-cost, safe, small and low-power miniature thermal batteries for mun

shift reliance upon a stressed wild population and eventually provide market needs with a farmed aquaculture animal.

-infrared generation and demonstrate a simple application by acquiring molecular absorption spectra using the SC source.

Savings in labor and reduction of scuba diving will be a key selling point OFT intends to market globally the technology developed through t
e NOAA P-3 for improved low wind speed and rain rate measurements.
odularity to ensure a long life cycle and complying with electrical and manufacturing standards to minimize production and support costs.

t digester is based on the robust plug fow architecture and includes specific design features to enable inexpensive maintenance and straigh

opes to identify different expression signatures at different levels of toxins corresponding to specific toxicity responses at low dose, and mo
recombinant protein for cellulose synergism with various forms of cellulose and cellulosic biomass. Once feasibility of the HED2 protein ha

er at drinking water processing facilities, monitoring water in air conditioning systems, and monitoring drinking water in distribution system

omics of biodiesel production for the dispersed group of biodiesel plants in the US, and provide an economic disposition for the major quan

very. However, its payback period exceeded the targeted one year set by our commercialization partner During Phase I avenues for cost red
the cost of a Kroll-produced sponge.

d to produce substantially higher burn temperatures compared to the current unit. The improved emissions and reduced potential exposu
the cost of a Kroll-produced sponge.
er at drinking water processing facilities, monitoring water in air conditioning systems, and monitoring drinking water in distribution system

Eon Research hopes to identify different expression signatures at different levels of toxins corresponding to specific toxicity responses at lo

e testing of the recombinant protein for cellulose synergism with various forms of cellulose and cellulosic biomass. Once feasibility of the H

oduce substantially higher burn temperatures compared to the current unit. The improved emissions and reduced potential exposure dura

conomics of biodiesel production for the dispersed group of biodiesel plants in the US, and provide an economic disposition for the major

very. However, its payback period exceeded the targeted one year set by our commercialization partner During Phase I avenues for cost red

frequencies, magnitudes, and energies with the relevant excitatory phenomena including fault modes. Second, we would extend our existi
will use the rules to assure that a system is operating normally and any hardware or software changes are certified through the MDA CM cy

fammability, corrosion, solvent compatibility tests as contained in the relevant SAE documents. Electrical properties, measured at AFRL, ar

will develop a prototype imaging sensor system that demonstrates the ability to measure the velocity vector angle in a real-time hardware

y and our extensive experience in developing 3D imaging lidar systems for applications in highly turbid medium with a newly developed no
tigated by configuring the vector instrument as a virtual scalar magnetometer (VSM), employing a coordinated combination of motion com
wn that the CHAOS design approach being proposed provides a unique capability with respect to autonomous operation, laser dazzle count

ram feasibility study will identify the design concept that maximizes performance within size and cost constraints and recommend a positiv

mbiguous ladar waveforms. The effort will specifically focus on the refining the waveform to include an interrogation component and featu
aluable for analyzing the effectiveness of LADAR sensors in tactical UAV and loitering missile systems.
ation data will also be collected.

f a library of over 600 "context aware", culture-specific behaviors originally developed for DARPA’s DARWARS initiative. By conducting form

toichiometric ratio, hence these limitless new compositions are finding unique applications in fuel cells, batteries, catalysts, etc.

ng files from primary storage.

he visualization system not only should facilitate collaborations among accelerator scientists in geographically different locations but also sh
require no human intervention (other than routine maintenance), use minimal calibration standards, and meet the generally-accepted des
royed during shock and vibration testing. Commercial Applications and other Benefits as described by the awardee: Government agencies

articularly. The compactness and low cost of the sensor technology makes it especially attractive.
ogy, MXLDV offers the prospect of a practical field instrument for composite NDE and defect detection which is many times faster than SLD
sk and will lead to a robust brassboard system design that will be built, tested, and validated in Phase II.

p the detailed engineering design of the TIL system, construct a brassboard and perform its complete characterization and validation. The P
able of withstanding prolonged cycling will be developed and tested in a high temperature furnace, and delivered at the end of the Phase I
t in the AEDC Range G.
tions in light-dark edges in the background.
fforts to identify and optimize the key system design parameters.
projection system that covers the full aperture. Achieved through a unique combination of digital holographic interferometry, Hartmann wa

oice. We are confident that the software and hardware developed at the end of Phase II will be important elements in future voice transfor

achieve the goals of this SBIR. We will utilize unparalleled techniques in computational probability to provide anticipatory traffic modeling

cating the strong potential that exists for commercialization of this technology.
rge user bases in the areas of computational fuid dynamics and numerical general relativity, and both had existing users at NASA GSFC. Pr
a commercial backing from Raytheon who has agreed to endorse the DAC team’s solution through Phases I, II, and III.
te the Bayesian Prognostic Failure Model into the deployed ASoSC2.
entation space and thus yield more expressive capability than other statistical relational formalisms.
d objective functions, an engagement management algorithm will be able to automatically apply the guidance, policies and strategies defin
sion within operational and communication limitations. Second, we are implementing this distributed fusion capability as a network-centri

develop the proposed capabilities in partnership and being sponsored through the Oklahoma City Air Logistics Center (OC-ALC) , Siemens U
initiatives have successfully transitioned current MRO practices into an improved position of effectiveness, they have also managed to high
oblems associated with clogging and short circuiting of the PHA filter bed were addressed by utilizing the PolyGeyser® bead filter technolo
salinity on the rate of ammonia oxidation and byproduct formation (e.g., nitrite, nitrate). Phase 2 will focus on designing, fabricating and te

er to produce hybrid catfish in the three weeks prior to the traditional spawning period. Research will focus on determining the feasibility
uch as ANNs. Finally, we will investigate incorporating these analysis programs into a hand-held device with an acoustic probe (Phase I). Fo

ays a firm foundation for extension of the studies in Phase II to use of SFP as a Fe fortificant in foods and subsequent commercialization by

elopment. The ultimate goal is to develop a library of images and image processing routines for commercial applications for a wide range of
ollaboration with expert researchers at the University of Arizona, Tucson, AZ and their collaborators at shrimp farms in Central and South Am

ARP vaccine along with the advantages of safety, specificity, and decreased production time will exhibit comparable or superior performan

P whole-air containers for CAFO odor assessment: (2) equivalency assessment relative to current passivated steel canister devices for gene
 uction is employed. The BIN may also be installed in established areas using trenchless construction methods. The extremely successful P

urrent research standard of erosion sensors.Furthermore,the proposed sensor can be produced for 1/2the cost of current saltation sensors
control of the daily light integral and CO2 concentration in commercial greenhouses to grow crops of consistent high quality and size, while

mportant area of Poplar phenotype screening. This information will be useful to government, university and industrial researchers intereste

dly, engaging, and at least as effective in relaying physics concepts as a comparable hands-on lab.

of substrate DNA can be made available to the meiotic recombination enzymes.

ensive nonrenewable polypropylene sheets for oil and other spill remediation.
travel to the central control system via one or more fixed communication paths. While the LED display will be based on current LED display

to the packing plant.

essary to allow different silos to exchange information work collectively over insecure networks such as the Internet.

wrence Berkeley National Laboratory of a new RF plasma neutron generator.

for commercial cruise line shipping lanes. Key Words sonobuoy, ocean buoy system, underwater detection, port security, underwater surve

onal layer of protection against illicit removal of radiological material from storage sites. This technology can be installed on video surveillan

independent) algorithms we develop can be ported over to other environments, including new bus (e.g. PCI express) and processor (e.g. V

to interface with current installed surveillance infrastructure to augment overall system performance; and 4)ability to inventory the source
d embedded hardware (2) distributed ad-hoc wireless communication network and (3) a software reconfigurable frameworks to enable cus

y fast and, in addition, can provide time and spectroscopy information over a wide energy range, including fast neutrons and is, therefore,

ecurity applications. Although this program will focus on developing a neutron source, alternative configurations will yield a photon genera

e II effort, the team will implement a full prototype of LNBC to provide a low-cost solution for cross-domain information sharing in a variety

ybernet and users of the MVS (such as local police) is a particularly important strategy for developing a commercially viable product.

verification, sender/receiver validation (to include digital signatures should PKI exist within the organization), enforcement of port-address

le by ensnaring the smaller, lower kinetic energy, rotating components in the undercarriage and rendering them immobile thus immobilizin

mmercial boron deposition system will be developed.

n to appropriate devices for processing, storage, and results display; and 4) a practical concept of operations that includes both individual a
prietary wiping system may be employed to wipe the chemical traces from the surface of the default trap.
roposed ME-based classification approach can automatically identify unknown chemical agents of which their signatures do not exist in th

ng key information to rescue and evacuation personnel.

independent) algorithms we develop can be ported over to other environments, including new bus (e.g. PCI express) and processor (e.g. V
s include the military and law enforcement agencies throughout the world, security personnel at airports, banks, private organizations, and
mmercial explosive detector. It will be useful in screening people, baggage, parcels, cargo, improvised explosive devices, etc.
ice, homeland security and defense applications, as well as warning systems for military aircraft.

etector based on microchemical sensor arrays that can be used to quickly and effectively detect the presence of hazardous chemical vapor
mble prototype hardware and initially test the performance with small gamma sources and thermal neutrons on a suitable reactor beam. F
ay systems in plug-and-play module for applications in homeland security, airport terminals, hospitals, military fields, and public transporta

ecifications for the Phase II small footprint prototype will be delivered in Phase I. Phase III commercialization probability for the portable, h
niformity in materials. The project will result in the fabrication of a dielectrometric gauge and a demonstration of how it can replace isotope
n use this system to screen passengers and baggage. The system will also benefit environmental pollution monitoring and military/peaceke

the NLG packaging design hide the detection process. In Phase I POC will demonstrate feasibility of the ESD3S prototype with direct measu
w enforcement agencies and surveillance industries operating on the sea, rivers, and lakes.
on and measurement times as fast as 250 microseconds. The proposed THz system will be able to make simultaneous properties such as w

formance benchmarks for both immunoassays and DNA tests, 2) extracting genomic DNA, 3) multiplexed and orthogonal assay protocols a

nology is immediately applicable to federal Government cyber security efforts, large network operations, ISPs, and security management so

ES data encryption and two-way authentication will be used to provide data protection as well as connection verification.
onstruction industry, TransTech is ideally positioned to transfer this technology to the market.
s database. The envisioned mobile biometric screening device will be a truly global biometric instrument, providing the DHS field agent or D

he focus of the Phase I project. The novel methods for reducing the forward fow pressure loss ensure superior hemodynamic performanc

ake measurements at will. ABQMR, the submitting company, together with New Mexico Resonance, has worked with MRTechnology, a Jap
e ulcers. These are to be delivered via web as well as other media. The materials will be interactive, accurate, effective, and extensible. The

nt, commercially available kits. This will enable microarray gene analysis with as little as 1 ng of total RNA with a single round of amplificati
hair and seating standards, and 3) it performs equivalently of better than other comparable manual wheelchair backrests on ANSI/RESNA te
tically over-represented motifs. The proposed research will develop computational tools based on these ideas and investigate the feasibility
A records that link to the general-use RAND-HRS data. The project has three main components: (1) port a general data synthesizer that was
re volumetric imaging to become common place in clinics for purposes of i) Advanced non-invasive diagnostic procedures (e.g. breast canc
, the goal of this SBIR project is to develop specific cell-based assays with minimal false-negatives or -positives using primary bovine retinal
sting in a rapid and cost-effective manner. Ideally, such a system should allow differentiation of light-dependent toxicity [phototoxicity] and
ts as well as developing an improved cochlear implant. This research will focus on enhancing the performance of the cochlear implant to al
rative files matched to several prominent Census surveys that incorporate protocols necessary for satisfying restrictive Title 13 prohibitions
MedRIC will carry out this effort with several prominent NIA-supported surveys as project partners. To meet the goals of this proje
s of the Phase I project are 1) to design and generate a bi-functional dendron ligand as a coupling reagent where the dendron molecule bea
the polysaccharides on the proposed slide platform. The resulting platforms will allow facile and effective fabrication of carbohydrate micro

digit was designed that provides the enclosing grasp children primarily use as opposed to high-force pinching grasp common for adults. Al
s in rats; and 4) synthesizing adequate quantities of two therapeutic candidates to support two models of cocaine addiction in rodents. The
ner in which specific parameters of the isolation and purification process interact to affect outcomes and the inability to control these para
r-substituted beta -CD derivatives and select the most potent compounds for further development as anti-toxin drugs. Provided that effecti
ons revealed that AMP could be used to characterize the changes in alertness, learning and memory associated with sleep deprivation in h
stem, a highly sensitive and objective method for quantifying outcome, 3) develop a system for monitoring and improving MAD titration, a
ssure and augment cardiac preload, can effectively treat and prevent hypotension during dialysis. The ITD works by providing a small amou
mately, a disposable lab-on-a-chip for newborn screening will be developed where one punch from the dried blood spot or fresh blood wil

a decade ago. Cell phones, which have quickly become ubiquitous, are becoming much more than devices with which to make phone call
years. AD symptoms typically first appear after age 65 and are the subject of longitudinal studies. There has been recent interest in the use
port these children, caregivers are appropriately concerned about traveling to a clinic only to learn that no intervention is necessary. The av
the United States, it is the second leading cause of worker absenteeism, yet the most expensive in terms of lost productivity. Nearly 80% of
ansmitted to a handheld computer or smartphone (a handheld computer with integrated cell phone) where it is recorded. Personal area ne
G nodes that integrate the functions of EMG sensing, signal conditioning, digitizing, wireless transmission, and power sourcing into a very s
The key advantage of the way-finding concept presented in this proposal, over other methods, is that the benefits are made available to th
ess communications. The UWB standard is officially designated IEEE 802.15.3a. The utilization of large bandwidth allows UWB to transmit la
eased tumorigenicity, 3) GP88 mediates tumor cell angiogenesis and invasiveness, 4) breast cancer cells overexpressing GP88 are resistant
earch and clinical laboratory setting. Importantly, the system is open-ended to the addition of new prognostic markers and drug targets into
matched controls, this test affords predictive accuracy that exceeds that of currently available circulating NSCLC- associated protein markers

ble with most current clinical vectors and is not available to academic researchers or small companies. A modest 10 fold reduction in RCA f

has not previously been studied in human brain tumors, a Phase I study must first be performed to assess potential toxicity of the combina
of NO, CO2, CO and OCS in exhaled breath will be designed, constructed, and deployed in a clinical research program. In the Phase II progr
e of the patients that need them the most, and the global warming potential is 1300 times higher for HFA-134a than for carbon dioxide. Ae
on/reaction/separation scheme that is anticipated to reduce the overall cost of artemether production. The first step, supercritical carbon d
nsight on biological pathways underlying neuropathic pain. Newly associated pathway information is used to identify therapeutics which aff
ying sleep disorders. PSU has recently developed a disc-treadmill method to perform sleep deprivation in mice based on electroencephalog
available. Here we propose to incorporate the touchscreen method with integrated sensor technologies to create an instrumented homec
unctional peptides termed interfacial biomaterials (IFBM's). Affinergy's IFBM's are designed to bind therapeutic biologic agents (cells, serum
o validate an "Interfacial Biomaterials" (IFBM) approach to attach an antibiotic onto metal implant surfaces to decrease implant colonizatio
mpting to improve synthetic bone substitutes with Affinergy's linker peptides. If synthetics were made more osteoinductive, they could prov
man bone marrow known as mesenchymal stem cells (MSC's), which have been shown to promote healing of bone and soft tissue (Caplan
n from the individual's baseline requiring intervention. The system will also have algorithms to identify certain disease conditions that prod
n, barrier membranes are an important adjunct to procedures aimed at restoring the form and function of the mouth. During these guided
ced healing. In addition to being highly cost-effective, this technology offers a low-cost alternative to the costly recombinant biologic adjunc
covering physiology, each group of students controls physiological variables of a single system/organ on their handheld computer, while a
1) the particulate matter sensor subsystem, (2) the data collection and transport subsystem, and (3) the data storage and analysis subsystem
us on InvTool and the process of automatically constructing highly intelligible personal synthetic voices for ModelTalker. In particular, our s

ntagonist for peripheral vs. central opioid receptors to define a therapeutic dosage range that relieves peripheral side effects without inhibi
ardized messaging interfaces. Facilitate transition of paper-based processes to electronic systems for electronic data capture of case repo
exible. The properties to be optimized in this study will be delayed swelling and fexibility Specific Aim 1 is the synthesis and characterizatio
rapidly identify infected persons and intelligently administer costly and/or limited quantities of antibiotics or anti-viral therapies either in th
ase 1 will result in a Phase 2 proposal where the specific aims will be to establish infuenza reverse transcriptase, multiplexed, microarray-e
nnel fuidic systems with this technology including Octafow(tm), which can currently integrate up to 32 fuid channels. The system we envi
to develop a detector system for a high sensitivity multi-well plate reader based on an array of our CMOS photon counting Geiger mode av
unting optical (GPD) detectors directly into a microfuidic chip which will detect target protein components with very high sensitivity using f
absorption due to its high density and high effective atomic number, a fast decay without any afterglow, emission in the wavelength range t
rocesses that are well beyond the capabilities of X-rays. While the benefits of neutron studies in biomedical sciences are obvious, the scope
it is necessary to monitor deep tissue hypoxic cancers, distinguish them from non-cancer specific hypoxia (i.e., due to physical injury etc.,)
ducts for lead content. Existing techniques are either very expensive or samples must be sent to laboratories. Thus, the availability of a prac
all scattering and rendering the material fully transparent. The procedure has been completely confirmed in experiments on polycrystalline
tors for reading out scintillation crystals in PET imaging.
hile minimizing the radiation dose to the animal. The efficacy of this system will be demonstrated by imaging tissue vascular physiology and
clear that nuclear medicine technologies are playing a prominent and an increasingly important role in cardiac care and clinical diagnosis.
d also to estimate partial volume errors in the lower-resolution PET scans, thus aiding quantification of the PET signal. The integrated system
d to a digital readout. This thermal neutron imaging system will advance the state-of-the-art of detectors used in macromolecular crystallo
ing the usefulness of text mining technologies in bioinformatics. This is where we are trying a different approach-we are focused on finding

e all of the technology needed for a substantial business opportunity to license the technology and manufacture commercial products.
ated testing of blood samples. While automated methods based on agglutination reactions and red cell detection allow for easier manipula
Ds. The cannabinoid class of compounds has been minimally studied because of the lack of a suitable drug delivery method. Oral delivery o
ethods will be developed to ensure robust performance of coatings under physiological conditions. Efficacy over time under these condition
pplication of ultrasound could help reduce the number of biopsies by up to 40% with a cost savings in conservative estimate of well over $1
highly advantageous. To that end a prototype nuclear targeting a-MSH peptide (DOTA-NT-MSH) was developed and shown to localize in the
obtained, totaling 1.5 Ci. Actinium-227 once purified can be processed for Ra-223. It can also be irradiated to produce thorium-228, a precu
eal-time, robust and sensitive diagnostic platform and is developing the Surface Plasmon Resonance-enhanced Common Path Interferomet
ii) methods to decode the randomly arrayed spots generated by PC-PRINT using photo-transferable DNA or mass-tags (PC-CODE). We prop
IVE-PRO was developed and evaluated using WT and drug-resistant forms of HIV-1 genes. Several important goals were achieved including:
or detection of chain truncating mutations in the APC gene using cell-line as well as a few patient-derived DNA samples (stool and tissue). A
y based on established non-genetic clinical criteria. Significant progress was made during Phase I in overcoming these limitations by develo
ortant roles in processes as diverse as early development, cell proliferation and differentiation, apoptosis and fat metabolism, and oncogen
been shown to be correlated with distinct prognosis in leukemia and MPDs. As the molecular pathogenesis for these diseases is becoming e

osh" detergents and micelle-soluble cholesterol derivatives. The test system for these studies is the purified KOR. However, the methods a
nificantly, at the 5% level, from the baseline to the intervention phase. In Phase II we plan to install RHHP at one or more hospitals and tes
e global diabetic population suffers from gastroparesis. The disease can cause extreme discomfort, pain, frequent vomiting and leads to a v
d overcome these logistical difficulties and provide effective therapy. Using a product discovery engine comprising phage display, 3-dimens
tic effects in vitro. Preliminary data in an in vivo model of progressive renal disease indicate that these small molecule SF/HGF mimetics opp
stability of proteins in solution and limited tissue half-life. Using a drug discovery engine that includes phage display, 3-dimensional molecu
f c-Met antagonists (with lead compound ANG 797) that compete at the ATP-binding site of c-Met, block c-Met activation and inhibit down
otential therapy for Scleroderma by inhibiting collagen synthesis. Other studies have shown that transfection of Hepatocyte growth factor
nd to providing an important source of cytokines and protease activity. Met and Tie2 are two receptor tyrosine kinases that have been iden
hat regulate HGF/SF/Met signaling to therapeutic advantage. To this end, we have identified a small molecule, Refanalin, that recapitulates

poxic or normoxic conditions. The A1 auxotrophic strain selectively grows in and destroys viable as well as necrotic malignant tissue but ha
against experimental anti-HCV compounds presently being developed and evaluated. Results obtained here will not only directly benefit dr
rowing demand. Diabetes is a growing worldwide epidemic that is particularly severe in the U.S and a more efficient bioprocess for human
there is promising pilot data for follow-on development of a commercial AMD screening test that can be completed in = 10 minutes. Our P
hibit epidermal hyperplasia. The overall goal of this proposal is the development of a PG-based psoriasis therapy, both for use as a standalo
e, preliminary in vivo studies showed that 1,25(OH)2D3-3-BE is non-toxic, and it strongly reduces androgen-refractory tumor in a mouse xe
of SRBDs. In particular, the SleepCorder's ability to quantify snoring, which will be validated in Phase 1 of the proposed research, is uniquely
to treat eye disease. In Phase I of this program, we demonstrated that our proprietary SK inhibitors block signaling pathways induced by V
ayed by Fas/FasL system in immune tolerance to self antigens, immune privilege, and lymphocyte homeostasis, and the extensive use of Fa
g a potent anti-tumor immune response as well as overcoming immune evasive mechanisms for a therapeutic effect. Various cancer vaccin
by the co-investigator of this application, Dr. Haval Shirwan. The ApoVax104 technology has been shown in preliminary studies to have pot
MS both improves the uptake of the constructs to MM cells and significantly increases the interference of the constructs with the ERK1/2 a
y in a proof-of-concept instrument. This technology, allows detecting crystals by virtue of their bulk properties (birefringence) rather than t
nistration of moderate sedation - Medvis will work with domain experts to define proper teaching points and guidelines for the moderate s
a holistic understanding of the patients gas exchange state. Data-driven visual metaphors will be refined through an iterative design proce
atient simulator and operating room settings. 2. We will expand the number of interaction models used within the PkPd Display to include

and hospital stay. Human apyrase represents a highly promising therapy to reduce ischemia/reperfusion injury associated with lung transpl
of primary wing-beat frequency and ratios of harmonics. To date this equipment has been applied by the inventor, Dr. Aubrey Moore, only
important species that is routinely used for the monitoring of coastal superfund sites. In addition, diagnosis of ecotoxological effects at the
ting stent (DES) as a multi- modal adjunct intervention to treat airway obstruction caused due to lung cancer. By virtue of targeting multiple
rization. This prototype will be evaluated by the University of Michigan in prospective, randomized controlled study comparing stand

er which does not require pipette intrusion ensures sample integrity while dispensing microliter aliquots of precious liquid. An interface be
volume continues to grow exponentially. The latest advances in automated information techniques offer a unique opportunity to bridge th
e-specific human mAbs are both opsonic and protective against both mucoid strains of P. aeruginosa as well as classical non- mucoid strain
to a BBB molecular Trojan horse. The latter is a genetically engineered protein that is able to cross the human BBB by receptor- mediated
ant advantage. The technology has the potential to be useful in basic research, diagnosis and prognosis of a wide variety of diseases.
will be first assessed in colonoscopy simulator tests. Then, clinical studies will be conducted simultaneously at two partnering organizations
neovascularization. Even if the efforts of these drugs become somewhat successful in inhibiting ocular angiogenesis for the short term and

se procedures, the animal must be securely restrained in an animal holder. In addition, the area to be biopsied must be firmly held in some
software components of the alarm system. Glucose clamp experiments performed with Sprague-Dawley rats will be used to establish the
ormation will guide the therapeutic intervention necessary. The major milestones in this Phase I SBIR project are first to isolate biorecogniti
MP conditions, exhibits therapeutic behavioral and histological benefit equivalent to those previously observed with allogeneic rat MAPC i
rder to reduce the frequency of handling and in turn, improve the well being of the animals under treatment, we propose to develop a long

n product to the other probe, creating the PCR template. This void-extension-ligation (VEL) reaction can be repeated many times making se
t limits the time that some patients will participate in the test. Other earphones are available that address some, but not all, of these probl
rojected to reach $30 billion in 2006. Several currently used antibacterial drugs belong to a group of natural products compounds known a
The successful completion of these specific aims will constitute a readily identifiable milestone which will permit us to continue with Phas
bcutaneous formulations of cyclosporine that demonstrated modest sustained release. We have now developed, in part with NIH SBIR fund
e Phase 1 report. We successfully delivered apomorphine in a sustained fashion for 24 hours in rats. The specific aims of this Phase 2 projec
ptantagonists) that antagonize TGF-a activity in cultured cells. Topical application of gel containing TGF-a peptantagonist promotes wound h
ng agent, however additional validation work as described in this grant is still required. Thus Phase I of this project will now assess the feas
study of diabetes. We have now developed an F derivative of DTBZ (18F-FP-DTBZ or F-AV-133) and have already completed (or have in pro
at would more closely model the challenge of human nerve grafting for severe traumatic or iatrogenic injuries. The overall aim of this Phase
95, which prevents axonal degeneration and peripheral neuropathy in an animal model of CIPN. Calpains are calcium-activated proteases th
atory properties - The objective of this aim is to produce rBCG strains that express the RD1 region, which has been shown to increase the im
ch a tool to the marketplace, based on proprietary TBI biomarkers. Previously, in our Phase I SBIR project, a sensitive ELISA for quantifying
correlations will be computed and exploratory factor analysis will be performed to assess the number of behavioral dimensions represente
m acute effects, predicting subsequent outcome, and suggesting specific intervention strategies for any problems noted. Although brain ima
tilized by the CAT-driven KnowPain instrument to optimize the efficiency of pain assessment via administration of a minimum number of ap

ndicators because both depend on vital functions as parameters of cell death. However, BCR's indicator is different because it measures ea

d disks, guaranteeing massive data bandwidth into the comparison hardware. The smart disk engine is designed to accelerate all stages of
rom the pilot study and expert panel; pilot testing of the final prototypes; and a randomized clinical trial (RCT) of the Windows version with
nd 4) lifestyle balance (balancing momentary and enduring satisfactions). Phase I goals are to develop and evaluate a broad breath, limited
-15 years) and late adolescents (15-17 years) are: 1) To determine, through a series of exploratory factor analyses, the global construct vali
ge of BA, recall of BA components, and self-efficacy in conducting the initial two sessions with patients with major depression. In the event
t for the prototype utilizing an advisory board of PCT and PCT-A experts; 2) Create the prototype using an iterative process of development
eveloped for detection of GDP. The Ga proteins will be mutated to increase the rate of GDP dissociation relative to GTP hydrolysis so that th
founder of Salus Discovery - and Dr. Huttenlocher developed the basic design for the static gradient chamber of the fFCXHTS and validated
tablished model of mammary epithelial acinar morphogenesis into a two compartment tissue model including fibroblasts. We will use this
d to expand the number of progenitors. Our ultimate intention is to commercialize the identified biological mediators for the purpose of ce
. To achieve these objectives, we will utilize the Caliper Life Sciences' bioluminescent prostate cancer cell line (PC-3M-luc-6M) to generate o

ystem exists that has the fexibility to enable both lower-load SC and higher-load LC training that is suitable for older adults and accessible
s or handling, should also improve the quality of data by reducing hormones which confound the study (e.g. catecholamine release redirecti

toreductases, nitrilases, amino acid dehydrogenases, aryl alcohol oxidases, human P450 oxidases, and many others. Processes based on th
of the four malignant lesions in the study (3 basal cell carcinomas and 1 squamous cell carcinoma). This 75% reliability rate in our first hum
Vaughan of Bioengineering, Inc., a small business dedicated to MRI-related diagnostics and therapeutics. We will develop robotics for remo
n of appropriate data before, during, and after implementation in two representative Test Laboratories will allow us to ascertain the impact
ors may be effective treatments in such patients, there is a critical need to accurately and efficiently identify these patients for these treatm
ding competitor for pWGA is multiple displacement amplification (MDA) marketed by GE Healthcare as GenomiPhi(tm) and Qiagen as REPL
with the robotic sample handling systems used in many laboratories and necessary for high-throughput screening. The UF filtration technol
ous, and tissue infections (Mycobacterium, Nocardia, Legionella), microaerophilic gastro-intestinal pathogens (Helicobacter, Campylobacte
y high-speed circuitry and analyzed by a proprietary software algorithm. Funded in part by the Phase I and Phase II NIH SBIR program, we h
ts as a nitric oxide donor. Our hypothesis is that this combination fuid will effectively regulate leukocyte recruitment and overcome the inf
studies, it was demonstrated that HAF can generate adaptable foam that is distributed uniformly, and adheres to the abdominal cavity, eve
a requirements analysis to identify the optimal exposure reconstruction methods and functionality to incorporate in the software; (b) Deve
al, and (2) long-term quantification of the benefits of current strategies for reducing the disproportionate incidence of cancer morbidity an
 arin County, California. Because humans are mobile, these new methods are a significant advance over approaches that ignore residential h
the mission of the National Eye Institute. Under Phase II, specific aims include system microminiaturization, packaging and biocompatibility
analysis technology. A micro/nanofuidic standardized platform based on continuous sample analysis in massive parallel fashion could dram
of proteins to identify new highly immunogenic proteins which can be recombinantly expressed in bacteria. (2) Develop a plasmid vector t
epitopes have been identified in key B. burgdorferi antigens such as the invariable region 6 (IR6) of VlsE, proving that peptides containing th
enzootic cycle of this pathogen. The major goal of this Phase I SBIR proposal is to test a bait vaccine by ad libidum feeding of the natural h
h as inulin. This Phase I application seeks support to further develop a novel readout system, based on immunoassay technology, to directly
usly and to obtain badly needed basic information to optimize for success in clinical trials. The project will develop tools that allow research
, and demonstrates that this reagent provides a strong T1 brightening signal comparable to the same molar concentration of gadolinium-DT
otype immunoassay to demonstrate the feasibility of measuring soluble TL1A released in human cell culture supernatant. However, as TL1
hat the protein can be safe and effective for preclinical and future clinical studies. The protein will be purified, PK studies conducted. Secon
can sit upright and fixate well for several seconds. In the last few years, Fourier domain OCT (FDOCT) technology has emerged as a superio
ave successfully completed the specific aims in our Phase I program and plan to continue development and validation of a field-deployable
aenzyme that catalyzes the biosynthesis of 6-deoxyerythronolide B (6- dEB), the macrolide core of the antibiotic erythromycin. The DEBS sy
moval from fuorescein-digalactoside). Recently, we conceived and have initiated development of a novel mechanism for eliciting fuorescen
wideband signals during movement, convulsive intra-ictal events, and post-ictal agitation; and 3) test in people whether the covariance of a
target" speaker. To tune the transformation system, parallel "training recordings" of the same text are needed from the source and target s
he feasibility of monitoring dysbiosis by fingerprinting rectal swabs and stool samples collected by the patient. Our second aim is to fully ch

of urban life, and celebration of cultural heritage are some of the many characteristics popular on contemporary Black radio. The emerging
pha prototype of SUPRAER(tm), which will deliver 2 to 10 times the dose of active agent per breath than current technologies. The resultan
ay is more rapid than nucleic acid sequencing and amenable to identification of organisms in biological mixtures and determination of thei
n of Phase II. To accomplish this challenging goal, we will concentrate our efforts in Phase II on the following tasks: I. BioTex chemists and co
eath is a distinct, intrinsic cell death program that occurs in various physiological and pathological situations. Disruptions in this process pla
th the planar substrate, the whole-cell configuration must be achieved, and fuidic pathways must be intact so that compounds of interest m
nd received enthusiastic feedback from subjects in our target population. In Phase II we propose to prototype a commercially viable consu
preoperative planner for TSA allowing implant sizing and orientation against the patient's preoperative CT data and simulation based upon
valuate different modes of administration. We will develop methods to produce sufficient quantities of the PEGylated muteins for further t
g cysteine-reactive PEGs. We introduced a new "free" cysteine using site-directed mutagenesis in regions of sFlt-1 that were believed to be
ffort to achieve an effective deformable mirror motion of 12fm, corresponding to 24fm of wavefront correction, and will be integrated into
atients who have other conditions that mimic PE. Three prior clinical trials of 370 patients (n=77 PE+) have demonstrated that the CO2/O2
local tissues to infection. Antibiotic strategies have proven to be of little value in preventing biofilm formation and encrustation of stents a
ctive barrier to prevent the subsequent colonization of cariogenic bacteria on the tooth surface, leading to a sustained anti-caries therapeu

nd made in real time. Real time measurements can be made using Caldera's technology because reactions are performed in solution. Calde
tallome proteins thought to be related to autism. RPM can monitor simultaneous exposure to toxins, such as arsenic, cadmium, lead, and m
mantles, spectrometers (UV-VIS-NIR), NMR, crystallography, fuorimeters, FTIR, TGA and DSC, microscopes, a customized EDAX Eagle III MXR
nd the laboratory of Rick Morimoto (Northwestern University). Scientists at Cambria have extensive experience in implementing high-throu
tion to identify potential therapeutic leads for PD via the following specific aims: (1) Establish a robust high-throughput screening (HTS) pro

ome setting. The company has constructed a number of device prototypes, which accurately and reliably measure salivary osmolality in th

nical data-using the human CPCs for cardiac regeneration in immunodeficient or immunosuppressed recipient animals-to enhance the com
on of sufficient surface PEG groups to prevent clearance by the body, but also targeting moieties such as antibodies to improve the specifici
cept prototype cerebral oximeter, we demonstrated that our empirically derived novel algorithm could determine absolute cerebral SctO2 w
both the assessment and feedback portions of the BASICS program with fidelity to the research supporting its efficacy (DVD 2). The goals f
study did not address either the behavioral or the cognitive changes associated with HUCBC injections. Thus, in this proposal we would like
uman endocrine progenitor cells by implantation beneath the renal kidney capsule in immunodeficient, diabetic mice. The recipients will b
o ex vivo manipulation and utilize these data to develop new methodologies for cell processing. These developments should have an impa
pplication; (2) It will incorporate the CryoPellet(tm) technology (frozen low dose chemotherapeutic pellets) applied in specific locations of
s will be designed through molecular analysis to be nerve cell specific; (3) The agents will also be developed to provide varying levels of zon
pendent manner. After choosing one antibody for further study, we will isolate and identify acetylated-lysine peptides from several cancer c

ciated with specific cancers and other diseases. We also propose to develop the capacity to transfer data from PhosphoSite(r) into pathway
"Manufacturing Processes of Medical, Dental, and Biological Technologies", more specifically, to the commercialization of a microfuidic cel
iological activity with pooled phage display libraries, concomitantly with a wide range of reporter cell lines compatible with this HTS techno
our biology consultants at the Fred Hutchinson Cancer Research Center (FHCRC) and the Scripps Research Institute (TSRI), we will subsequ
nd software for prediction of effective shRNAs. Under Phase II, we propose to develop a FV shRNA data set for 20,000 human genes selecte
essful expansion and cryopreservation of these myeloid progenitor cells (MPc). The rationale for our hypothesis has been established by ou
erates vaccines that are highly contaminated with contaminant proteins or other materials.
s from serum or plasma samples remains a difficult and expensive process that, in part, hinders the adoption of these technologies in deve
d cardiomyocytes (hESC-CMs) to predict cardiac toxicity in humans. The goals of this proposal are: 1) to establish genetically modified hESC
ew generation of Raman spectroscopic sensor based on multimodal multiplex spectroscopy. The key technology objectives are to develop a
eally suited to exploit the many features of SERS nanoparticles from Oxonica, Inc. These glass-coated metal nanoparticles loaded with Ram
, TRS will establish deep etching for single and multilayer 1.5-D arrays that can allow for frequencies from 5 MHz and above, develop via m
andwidth with one acoustic matching layer, which is significantly higher than current commercial IVUS transducers. For the Phase II progra
patented technology, known as neoglycorandomization, toward this goal. In this Phase I proposal, we will demonstrate the feasibility of cre
ker inhibition of the human Na/K-ATPase in a cell based assay. Synthesis of additional cardiac neoglycosides and comparison of their cytoto
C using a porcine model. This exceeds the 16h documented to be the present clinical limits of safe, static cold storage of donor pancreata. H
rket opportunity. Applying the technology to veterinary medicine could expand its sales potential even further. Each year over 1.5 billion Co
tive) using MCF-7 cells. In this Phase II application, CCi now proposes to develop this robotic assay for anti-EA for commercialization by repe
ed potential inhibition of retinal NV. However, high doses of CA4P caused significant toxicities. Four phase I clinical trials in humans demons
nally, the company has a strong R&D partnership with the University of Oklahoma Health Sciences Center (OUHSC), and relationships with
esized a series of novel thalidomide analogs. In the Phase I studies, the in vitro assays have shown that three of these analogs, Compounds
curate diagnosis. The goal of the research proposed here is the development of a rapid, point-of-care diagnostic test for human leptospiros
ectrochemical-based hybridization sensor, and 2) confinement of each sensor using microactuators. The new sensor relies on an array of sp
chemical libraries. We also propose to conduct follow-up experiments to determine the specificity of any new inhibitor identified in the sc
gram is successful, a Phase II proposal will be submitted for the construction and testing of a prototype filter module for the application stu
test that would serve as the earliest sign of high-risk pregnancy in asymptomatic pregnant women. Our goal in Phase I is to assess feasibilit
for training in cultural competency. In addition, the technology developed here will be directly applicable to treatment of other social grou
roliter-scaled samples of blood readily harvested with minimally invasive procedures (e.g., fingerstick capillary blood sampling). Such real-ti
e disease. This, in turn, should lead to improved patient care, better outcomes and reduced patient care costs. The proposed system will co
of patient sample. The proposed system is based upon integrating patent pending MHC-peptide array technology with an automated fow c

and oculomotor activity. The proposed Multivariate Parkinson's Prediction System (MPPS) will be a non-invasive, easy to use system of sma
f putative neurotherapeutics, since lipophilicity alone is a poor predictor for drug penetration into the CNS. This is particularly true for thre
ementia caregivers with online, interactive education and care management tools in the form of tailored content, skill-building activities, d
 ointed out by one of our experts in Emergency Medicine and the Program Director of the Pediatric Emergency Medicine Fellowship at Rain
tion of novel muscarinic agonists, 2) In vivo CNS penetration, functional activity, and selectivity, 3) Scale-up and analytical chemistry and 4)
ascular Aa deposition in the absence of parenchymal fibrillar plaque amyloid. More recent work from our laboratory has demonstrated tha
es, histological outcome measures and measures of a panel of representative infammatory mediators. Specific Aim 3: Using a DSS model o
E (ApoE) provides a convergence point for these factors. Several reports implicate the e4 allele of ApoE as playing a critical role in the age o
mplete evaluation of COG133 in more relevant single species bacteremia mouse models of sepsis. Sepsis syndrome induced by both gram p
i, Inc. has innovatively designed peptidochemicals to mimic the bioactivities of apoE holo-protein that also display therapeutic efficacy in E
mine the mechanism and relative efficacy of three more potent and more drug-like COG compounds in established models of MS. In specifi
formulation for ease of delivery, with an appropriate strength profile that will be effective in bonding small bone fractures. To test this hyp
perating room environment will require significant innovation in both product formulation and device design. To test this hypothesis, the fo
ncing the protection afforded by a limiting supply of infuenza vaccine. We will test whether our topical adjuvants 1) accelerate the develop
d speech. In Phase I, speech perception problems for English syllables will be assessed for ESL learners from four L1 backgrounds. Based on

armaceutical companies as well as leading researchers have committed to actively participate in this program. This participation will enhan

alogs and screen them for their ability to inhibit SGLT1 and/ or GLUT2 using isolated mouse intestinal brush border membrane vesicles (BBM

plants of all types will also be developed. The prototype instrument will allow the assessment protocol to be performed either in the sound
to the vacuum system, housing the miniature FTOF-MS and the charged particle detector, in the form of short pulses (~ 100 ms duration) o
uld place the number of Americans with a lingering pain problem at approximately 80 million (National Research Council, 2001; U.S. Bureau
clusion, finite ion size, image effects at the molecular surface) and achieves fast computational performance using advanced numerical me
ngth of the soldered repair was dependent upon reaching a precise temperature set by choice of laser, solder composition and film thickne
ture an ultra-compact and inexpensive microchip spectrometer. The specific configuration of the liquid crystal material to be used, ferroele
odate large deficits with a single procedure. A robust prototype intra-oral mandibular distraction device (BTRP-01) was built using Phase I ST

LFDI-CAT. In Phase II of the research project, we will examine item calibrations of the original LL-FDI, add new items to broaden the range o
nent will be evaluated in Phase I to demonstrate feasibility. Focus groups of stakeholders-clients, caregivers, and professional staff-will prov
e specificity through customization to patient factors that our analysis unearths are most important such as age and comorbidities; 2) Impro
ant need and build upon existing clinical acceptance of the NuStep device. The goals of this Phase I project are: 1) to modify and instrumen

therapeutic decision time. The specific aims of this Phase I project are (1) to develop a noninvasive methemoglobin sensor that incorpora

cceleration of the process, as compared to current methods. The goal of Phase II is to build upon Phase I success by pursuing the following

d biomechanical testing, and functional integration with vital bone will be assessed using a subcutaneous pouch model in an immunodefici
by HLA-A2 in A375 cells. For the cytotoxicity assay we have chosen to use A375 tumor target lines transfected with Enhanced Green Fluore
e activity relationships by screening a focused chemical library. The data contained within this application are an exciting first step in the de
of cells similar to EPCs that are capable of participating directly in repair and regeneration of the endothelium. However, while endotheliali
eks to continue the development of a novel approach to using an NMR-based method. The primary idea is to simply arrange for the large p
organizations or schools. An innovative STRIVE component will also include co-facilitation by a young adult with AS/HFA who has successfu
confict resolution package are to: 1) Serve as a research-based, empirically tested, psychoeducational curriculum that is effective and appr
EAT) program. The fundamental goal of TREAT is to inform and educate cosmetologists, clinicians, and other stakeholders about TTM and p
ocket guide, will help to "re-orient" mental health professionals (social workers, psychologists, case managers, psychiatrists, intake workers)

n a facilitator's guide that will include the following sections: (1) an introduction and overview of how to use the program; (2) counselor, pa
 ralized linear mixed-effects models GLMM, marginal models or transition models to non-continuous data. The difficulties for such models s

certainty about the future, poor self-image, low self-esteem, and frustration with delayed growth/maturation all of which can impede adhe
4) a greater sense of hopefulness about the future for themselves and their relative with BPD. The specific aims of this proposal are to: 1) D
ehaviors in a biologically and developmentally appropriate manner. Once developed, MSC will consist of: (1) a Teacher's Guide with gender
eatment of childhood neuroblastoma. Subsequently, DEKK-TEC has partnered with Duke and Research Triangle Institute (RTI) to complete t

Training Module: Sleep Behavior Disorders in a DVD/Web DVD format that provides enhanced interactivity and an ability to update training
eople's Republic of China 2000 Census data to 2006, producing estimates at the township and 1km grid levels. These estimates will draw u
ming MIS. This system will allow the surgeon to easily perform MIS and will bring to the patient the advantages of MIS. The commercial po
ity hosts readily accessible through fraternities and sororities, who face special challenges in protecting minors from alcohol. The program
have been identified as barriers to practice. The overall goal of this project is to develop an interactive web-based training program which
ments demonstrate the feasibility of the bRCQ molecular design, as well as provide fundamental understanding of correlations between m
ng key characteristics and descriptions of their needs. Input from experts and potential users will help create a data delivery system that al
when approved, will allow the DRW HBsAg Rapid Test to be used in clinical studies. The clinical studies aimed at a PMA submission to the
nt creation, assay formulation, and clinical validation. Studies in our laboratory to optimize the DCP technology have successfully focus
ty reagents will immediately be available for the development of diagnostic tests for the biomarkers. Thus DCP will play an important role i
A powered clinical study will be performed to evaluate the system's ability to improve the adherence to HIV/AIDS medications over time. It
all feasibility of SPIMA to predict a patient's mood and response to medical therapy over time. In the phase II study, SPIMA will be validated
its partner interact, EA and ProLabel will recombine to form active 2-gal and a luminescent response, which will be lost when a drug block
e spontaneous, robust complementation of EA and ProLabel was transformed into a protein interaction detection system by mutating the P
d by construction of a LTT targeting tether comprised of a LexA DNA-binding domain fused to a ligand specific for hepatocytes and construc
e II application, the overall goal is to provide key preclinical data that will be necessary to support the anticipated efficacy of SB-mediated g

nto a 'smart' safety cap. The safety-cap mounted personal exposure measurement system is an elegant solution to two distinct requiremen
urrent regimens. During Phase I efforts, bioinformatic filters and functional genomic (RNAi) data from the model nematode Caenorhabitis e
ampling (i.e., equivalent to a 40X magnification). The proposed liquid lenses are designed to rapidly adjust focus or to enable extended-dep
hybridization, representing potential false positives. Thus there is a need to develop an algorithm that combines the efficiency of BLAST wi
hardware, especially the optics and mechanical drive components. C. Develop a continuous or semi-continuous process for gel production
N and spectral resolution in 13 MRS. Ultimately, human MRS applications where sample losses are not dominant will also benefit from Cry-
oposal seeks funding to begin the development of an ultra-high-power triple-resonance 900 MHz NMR probe with order-of-magnitude redu
fficiency and expand experimental protocols.
acturers. In Phase I of the project, we adapt our existing specialized high-speed large-area CMOS readout chip, specially designed for comp
g this, the following additional features can be obtained: counting (and analysis) of each individual x-ray, binning events according to x-ray e

us frequency-amplitude modulation. Instantaneous BP-BFV phase relationships will be used as a measure of dynamical autoregulation. 2) T
biotic screening success based upon use of advanced E. coli heterologous hosts. Success will point to a new level of accessibility to as- yet-u
equipment. The chemical reactive wear of diamond tools resulting from the surface-catalyzed reaction between diamond carbon and work
y and prevention of child and adult obesity. However, the methods that are currently available to researchers and clinicians, such as isotop
ng enzymes (proteases) that infection-causing pathogens release into wound fuid. Since proteases are specific toward particular sites with

pply in vitro selection to identify allosteric DNAzymes that have high selectivity and sensitivity to the mycotoxin deoxynivalenol (DON) and o
The long-term goal of this proposal is to develop a therapeutic agent that gives sustained delivery of a cell protective compound to the gin
e other drawbacks for commercial production of proteins. About 20 grams of SLPI will be necessary for a good size preclinical test, posing a
ns isolated from inclusion bodies, 3) misfolded soluble proteins, and 4) misfolded proteins found in disease states. Studies have shown that
are completed, full-blown field tests for each IM program will be completed with approximately 120 middle and high school students with
 the science of DNA translocation through protein pores. The proposed direct electronic sequencing of DNA method could allow the ability
ed project aims to further develop a glass nanopore system, previously developed under a DARPA project, into a nanopatch device capable
also be specifically designed for home and traditional school use, as well as for community science centers and museums. Science activitie
daily exposure/daily ingestion of pesticides. The SERS sensors will be read using a battery operated Raman instrument with keyed sampling
microarray readers. In the proposed approach, proteins in a sample are detected directly, with no protein analyte premodification or sandwi

king. The objective of Phase I was the validation (with statistical significance), in a canine model of reperfused MI, of the PIM method to pr
ecessary training and background for instructors to use our system appropriately. The commercial potential of our system is high given the
been encountered before. However, the diversity of "uncultivable," (yet-to-be cultured) microorganisms is far greater than that of organism

erial that provides detailed descriptions and guides based on successful experience. The product will provide online and CD-based training
a sets ready for analysis, c) producing specified sub-population and specific geographic comparisons and trend estimates, and d) outputting
the AAC user becomes frustrated. Another reason indicating the need for the VG tool is that having a way to communicate more clearly wi
% provided by touch prep or frozen section); require no specialized personnel or sample processing (cutting and staining); and will require
el will provide performance benefits over traditional agents because of: (i) minimal preparation time, (ii) rapid gelation within the vasculatu
this project is to develop a biocompatible and biodegradable in situ gelable carbohydrate hydrogel without the limitations of the liquid em
w" range of wavelengths and determined that an x- ray microscope based on the light source is feasible. A "proof of principle" microscope w

pting its existing aerosol concentration and collection technology and Micronics, Inc. will adapt its commercial microfuidics card technolog
ding several classes of interferences and environmental variables. Once fully characterized, the prototype will be tested in the field with sel

will also be able to test their own skills at performing these tasks in computer animated versions of the standard psychophysical tasks used
cess of the treatment, though, has reduced the Rh immune globulin supply by decreasing the number of individuals sensitized to the D anti

ues, in nearly 1,500 people. The Phase I clinical data shows that the Standard Deviation (SD) for APD is smaller than IOS on identical measu
nd LIF from rabbit origin will increase the chance of getting germline competent rbES cells. We expect to derive at least 20 putative rbES c
addition, sensitive plasma-based assays have been developed to quantitatively measure the extent of inhibition of the intrinsic coagulation
r targeting intracellular drug targets not amenable to antibody treatment. Extension to these uses requires a substantive increase in throug
y, where dose escalation by volume increase could be detrimental to the patient. The research plan of this project is to generate highly con
g that the effects of lacritin observed in cell culture can be replicated in vivo and can form the basis for the preclinical trials proposed for Ph
for the detection of splice variants; ii) develop and qualify an antibody array for the measurement of protein isoforms from two genes, Bcl
te CD4+ counting assay with these attributes could be manufactured that would cost the end-user less than US $1.00 per test. This assay c
n route, antigen targeting, adjuvant) to induce the greatest immunogenicity as assessed by cytokine production of stimulated immune cells
cell-dependent antibody formation. The aims of this Phase I SBIR are to (1) identify and select the key immunodominant T-cell epitopes in
ectly measure enantiomeric excess of chiral ingredients in pharmaceutical products, may serve to increase throughput for chirality measure
h excellent specificity that can accurately discriminate between ethanol and other molecules (e.g., acetone, methanol, toluene) that may i
ication, be added along with the medication to a special capsule or be added as an excipient. We have considerable expertise in the detecti
agents for plaque formation in patients with atherosclerosis. To test this hypothesis we will develop ATE that will be endocytosed by foam c
din-coated microplates to immobilize the biotinylated molecular markers. Phospho-specific antibodies will be used to quantify the phospho
, along with a previously published study that describes positive results of free fat engraftment in rats using adipose tissue that was delipid

phosphorylated FAS which would not react with FAS derived from normal tissues such as liver. The goals of this Phase I SBIR are to determin
to other industrial fermentation processes of medical importance. The model organism used in this study is the erythromycin producing or
mercial development of critically needed new natural products, and to improve the production of existing products to reduce the cost of pr
al use through improvements in the probe properties and assay format. To accomplish the first aim, probe measurements of UCBf will be c
e and Gautam Ghatnekar are co inventors of a class of novel bioengineered peptides - we refer to as ACT peptides. Based on our data from
pplication in many assays, including in human diagnostics and research markets. In preliminary studies, a proof of concept showed that thi
hysiological response to PM exposure by profiling key marker proteins in conveniently available biosamples such as a finger pick of blood, u

nt interactions in the hospital and by recruiting Spanish speakers to call Sehda's telephone-based data collection system. Sehda will transcr
GFP that serves as a marker of collagen synthesis in chondrocytes and Specific Aim 2 is to track the activity of collagen cross-linker formati
ohydrate synthesis protocols will be developed. 3) Development of purification conditions for carbohydrates derived from automated synth
RNA) for target identification and validation. Awardment of this Phase 2 grant would allow us to continue to further develop our single-cell
(c) a 1-year experimental test of the impact of the product on student outcomes. The long term goal of this SBIR project is to offer, via a sta
mmands. In its final form the implant will monitor and regulate IOP and be capable of sending IOP data and information concerning valve f
this current SBIR Phase I proposal, we plan to use RHGP to randomly inactivate or activate genes in HIV-1 permissive cells, one gene pertur
8 receiver-channel coils have been combined in some systems presently under study, most commercial RF coils have no more than 8 chann
rature as to whether androgens are beneficial or detrimental, there is a critical need to devise an effective screening tool to better define th
tiomers, which we have resolved from the racemic compounds called PRC006, PRC011, and PRC012. All these racemic mixtures are active
ated environment with more efficient, large-scale correlation algorithms and an intuitive graphical control console.
Finally, our proposed work includes detailed consultation with established manufacturers of naval composite materials, to ensure the AMM

o highlight improvements available from use of new design and materials.

elopment tools used for this project are entirely open source (Linux/GNU), and the firmware is developed using the familiar MATLAB platfor
odel will be validated against first principles computations and existing and new test data.
er signal processing is governed by dynamic parameters that are prescribed to change as needed throughout the interceptor fyout.
persistence and reuse for analysis of alternatives based evaluation.

ess node parameters within a framework comprising: Strategies in selecting inter-domain routers; Route computation strategy; Route Adap
example weapon control application in accordance with requirements developed under the Phase I study effort.

etwork control, toward the specific goal of detecting and shunting information leakage.

ocessor that interfaces with the transceiver and input/output (I/O) and controls I/O subsystem. The resulting miniature, lightweight, low-po

d false alarms from unrestricted or noisy areas.

sign will be undertaken in a follow-on Phase II program

munications related R&D projects.

ird party tools.

proach, enables the consideration of cross cutting system aspects (security, safety, dependability) and demonstrates the scalability and tec
ng issues as early as possible and improve overall system quality.

model to be used to evaluate the SATCOM network performances.

D of this sensor suite involves both hardware and software algorithms.
he Fleet Numerical Prediction center's NPW models. We call this concept the “Automated Dropsonde Atmospheric Measurement System”

ivery of vastly improved batteries with both traditional and iron phosphate technology.
architecture, a field-testable prototype system is achievable by the end of the Phase I. This Phase I effort will culminate in a high-quality p
enhancements during Phase II. The primary tracking device will maximize the use of recent advances in commercial-off-the-shelf (COTS) Mi
nsors. In case of positive results of Phase II efforts, specialized microwave sensors and systems will be designed during Phase III for robust d

of the principle.
adily applied to establish improved control surface free-play criteria for modern aircraft.
rphing. Finally, NANSI.AE along with each sub-domain solvers will be validated on a folding wing and MAV wings with available solutions an
ear tire without defection and put 3 sensors behind the rear tire with defection and sample their data simultaneously then make average a

e-ready drawings for a prototype brake. Further optimization will be performed on the model to taper the spear in order to decrease the t

odeling and simulation approach conducted in Phase I, the Phase II project will develop the detailed design, fabricate and validate the BICS
PLADAR and Performing Field Tests. The Navy is currently developing a 3-D Ladar for FireScout, which will be evaluated under an ONR FNC

striped) hybridized arrays will be characterized to quantify operability gains. Hydrogenation is readily implemented as a straightforward add

dividualized training regimen.

e materials are lightweight, breathable, and ultrasound transparent, allowing the prosthetic to function in a variety of environments.

or prequalification. Infoscitex has teamed with an optical products supplier and a solar array manufacturer to commercialize the SEHB tech

understanding of the dynamics of the interrogated moving targets. In addition to the data that may be provided by AFRL-WPAFB, Goleta St
 ncludes experts in coating deposition, materials and processing, and sand erosion testing.
vesting systems in a water environment.

partment of State’s Coordinator for Reconstruction and Stabilization (S/CRS) Post-confict Reconstruction Essential Tasks. This methodology
explored. Furthermore, we will maintain adequate power density in the battery despite the introduction of solid-state Li+ conductors in th

ultation with our industrial advisors and our Co-investigators at the two University of Texas institutions.

ode transformer integration, EO modulator device design, fabrication, test and packaging as well as overall project management will be pro

niversal sample preparation method that relies on little power to produce the nucleic acids for any biodetector.
h-performance computing on military-qualified IAC systems, and a novel software architecture that enables rapid development and deploy
o produce a multi-megawatt thruster at high efficiency and low mass.
dvantage of newly developed techniques for polymer melt infiltration into photonic crystal structures.

ure of actual missile threat being engaged.

nformation Directorate; and JPEO/PM JTRS HMS under the DARPA ECHiPPS Program.

ow rapid screening, development, and optimization of potential alternative lethality enhancing configurations not adequately covered by ex

red and unstructured meshes (1D/2D/3D) representing various levels of modeling fidelity for conceptual, preliminary, and detailed analyse

ware modifications; and evaluating the pedestrian detection algorithm performance onboard a tactical UGV platform under urban outdoor
ost, safe, very small and low power thermal batteries, particularly for fuzing applications.

lusion, our work represents the first complete solution that provides seamless handoff in ad hoc networks with minimum service disruptio
oint of origin, or from an intermediate shipping point such as a military medical depot, to the point of use. This research demonstrated that

several NASA missions planned for the immediate future including the Mars Science Laboratory. Future mission applications include the M
als into the engine system, and generate electrical power to operate the various subsystems.

iature thermal batteries for munitions applications.

ure animal.

g the SC source.

technology developed through this SBIR effort to owners of Aquapod net pen and other submersible and surface net pens.
e production and support costs.

pensive maintenance and straightforward operation. Avatar also has developed a low-cost solids separator to separate the digested manur

y responses at low dose, and more general stress and cell death responses at higher doses where acute lethality becomes apparent. Additio
easibility of the HED2 protein has been demonstrated, Expansyn Technologies will follow up with a Phase II proposal in which the synthesis

king water in distribution systems.

ic disposition for the major quantities of byproduct glycerol, thereby facilitating rapid introduction of economic biodiesel manufacturing op

ring Phase I avenues for cost reduction and performance enhancement with the modification of our existing commercial membranes have

ns and reduced potential exposure duration (reduced burn time) will incur only a nominal increase in capital cost, with expected zero impac
king water in distribution systems.

o specific toxicity responses at low dose, and more general stress and cell death responses at higher doses where acute lethality becomes a

iomass. Once feasibility of the HED2 protein has been demonstrated, Expansyn Technologies will follow up with a Phase II proposal in whic

educed potential exposure duration (reduced burn time) will incur only a nominal increase in capital cost, with expected zero impact on th

nomic disposition for the major quantities of byproduct glycerol, thereby facilitating rapid introduction of economic biodiesel manufacturin

ring Phase I avenues for cost reduction and performance enhancement with the modification of our existing commercial membranes have

ond, we would extend our existing application domain to high speed turbo-machinery, making the necessary adaptations and modification
certified through the MDA CM cycle.

properties, measured at AFRL, are excellent – dielectric breakdown voltage is 90 kV/mm vs. about 25 kV/mm for Tefon and kapton. High ten

or angle in a real-time hardware-in-loop simulation. Phase III commercialization will be encouraged via demonstrations with government a

dium with a newly developed non-mechanical beam steering technology pioneered by Vescent Photonics. This combination of technologie
ated combination of motion compensation, advanced processing, and real-time in-sensor calibration compensation.
ous operation, laser dazzle counter measure, and threat coordinate localization. The overall goal of the project is to prove the feasibility of

traints and recommend a positive Phase II approach.

errogation component and features that will allow adaptive waveform operation for closed-loop target detection augmentation.
 RS initiative. By conducting formative and summative evaluations of the prototype simulations and authoring tools, we will iteratively refin

tteries, catalysts, etc.

lly different locations but also should enable scientific discovery through images and animation of massive amounts of electromagnetic fie
meet the generally-accepted design specifications of aviation authorities. Commercial Applications and other Benefits as described by the a
awardee: Government agencies around the world are already installing atmospheric monitoring stations. The Amerifux network currently

ch is many times faster than SLDV and many times more sensitive than ESPI or shearography.

acterization and validation. The Phase II effort will culminate with TIL system demonstration.
livered at the end of the Phase II, together with the sensor readout system, for use in further evaluation and experimental demonstrations

hic interferometry, Hartmann wavefront sensing, and adaptive optics the resulting instrument will be an extremely fexible tool.

elements in future voice transformation systems.

de anticipatory traffic modeling to drive our SRM, as well as to provide improved track correlation.

existing users at NASA GSFC. Prior to our Phase I work, there was no way these user communities to collaborate directly, leading each use
I, II, and III.

nce, policies and strategies defined by the plan to the execution phase of an engagement.
on capability as a network-centric ISR Service that will discover, compose and manage an ad-hoc team of sensor and fusion-capable assets

stics Center (OC-ALC) , Siemens UGS Software , and the National Center for Manufacturing Sciences (NCMS) . OC-ALC will provide access t
, they have also managed to highlight the remaining inefficiencies that pose challenges in the present MRO environment.
PolyGeyser® bead filter technology which promoted a healthy thin biofilm due to its characteristic frequent and gentle backwashing. This P
s on designing, fabricating and testing a commercial-scale unit for removing ammonia from tanks stocked with fish. Additional markets for

s on determining the feasibility of utilizing existing geothermal well water and recently developed ultrasound techniques to monitor oocyt
h an acoustic probe (Phase I). For Phase II, we envision working prototypes and systems built into sentinel hives for remote management o

bsequent commercialization by BioLink Life Sciences, Inc. or interested companies. If SFP proves to be the useful Fe supplement/fortificant

l applications for a wide range of soils.

mp farms in Central and South America. In addition, we have also established a collaboration with Dr Jeff Lotz, Department of Coastal Scien

mparable or superior performance compared to other vaccines in a vaccination-challenge model and as measured by clinical signs, lesions,

d steel canister devices for general trace volatiles emission protocols and (3) prototype thermal desorption interface, coupling the optimize
ods. The extremely successful Phase I effort, including participation and encouragement by representatives of three major utilities (SBC/AT

cost of current saltation sensors.

istent high quality and size, while significantly reducing electricity required for supplemental lighting.

d industrial researchers interested in enhanced root characterization instrumentation.

 be based on current LED displays in the transportation marketplace.

e Internet.

, port security, underwater surveillance, vessel detection,

n be installed on video surveillance systems at numerous traffic choke-points and at potential terrorism targets.

CI express) and processor (e.g. VMX) architectures. Key Words Cyber Security, Rootkit Detection, Coprocessor, Integrity Monitor

4)ability to inventory the sources under surveillance. The proposed system can also interface with databases used to keep track of the sou
urable frameworks to enable customized body area networks.

fast neutrons and is, therefore, capable of identifying threatening incidents at the speed of life.

ations will yield a photon generator that will also be useful for DNDO applications.

n information sharing in a variety of digital media for Homeland Security as well as other civilian operations.

mmercially viable product.

n), enforcement of port-address restrictions, malicious code detection, dirty word checking, content screening based on semantic distance,

them immobile thus immobilizing the entire vehicle.

ns that includes both individual and command center analysis modules. A bread-board instrument with individual & command center graph

heir signatures do not exist in the database. The classification results from different multidimensional chemical analysis techniques will the

CI express) and processor (e.g. VMX) architectures. Key Words Cyber Security, Rootkit Detection, Coprocessor, Integrity Monitor
banks, private organizations, and everyday citizens seeking personal and property protection.
sive devices, etc.

nce of hazardous chemical vapors.

ns on a suitable reactor beam. Final testing and performance characterization will be carried out using fast neutron sources at NSTs Andrew
tary fields, and public transportation systems, which are portable, robust, and has low rate of false-alarming.

on probability for the portable, high duty cycle electron accelerator is high, with widespread interest and applications.
tion of how it can replace isotope gauges.
monitoring and military/peacekeeping security monitoring.

D3S prototype with direct measurements of explosives simulants in critical near-trace-level concentrations. In Phase II POC plans to develop

multaneous properties such as water and basis weight.

nd orthogonal assay protocols and demonstrations, and 4) reader/cartridge prototype development.

Ps, and security management solution providers.

on verification.

providing the DHS field agent or DOD screener ready access to up-to-date biometrics data anywhere in the world, as well as the means for c

erior hemodynamic performance without compromising valve efficiency, durability and fuid fow patterns through the valve. Phase II studi

orked with MRTechnology, a Japanese company specializing in permanent magnet based MRI. These MRI systems perform standard imagin
te, effective, and extensible. The media and site will address pressure ulcers in terms of both prevention and treatment and will target hom

with a single round of amplification or microarray profiling from a single cell (-10 pg of total RNA) after two rounds of amplification.
hair backrests on ANSI/RESNA tests. A consumer and clinician focus group will evaluate the prototype models and their feedback will be in
 as and investigate the feasibility of the techniques on diverse and large data sets. Graph-based techniques for similar compound retrieval,
eneral data synthesizer that was developed at the U.S. Census Bureau for use with SSA data linked to the Survey of Income and Program Pa
stic procedures (e.g. breast cancer, internal bleeding, heart arrhythmias etc.), ii) Non-invasive inter-operative guidance for minimally invasi
ves using primary bovine retinal cell culture and an immortalized RPE cell line, ARPE-19, to screen large amounts of compounds in 96-well
dent toxicity [phototoxicity] and general toxic effects, and would mimic in vivo toxicity. Therefore, the overall goal of this multi-phase SBIR
nce of the cochlear implant to allow people to hear speech in a crowded room.
g restrictive Title 13 prohibitions on data distribution. To meet the goals of this project, Phase I will accomplish eight specific tasks:
To meet the goals of this project, Phase I will accomplish seven specific tasks: (1) formalize arrangements with CMS for adding the MDS a
where the dendron molecule bears multiple identical acyl-hydrazide coupling points for carbohydrates and a sulfhydryl for attachment to th
abrication of carbohydrate microarrays. The proposed novel slide platform will significantly increase the efficiency of glycan analysis and m

hing grasp common for adults. Also included was a Variable Mechanical Advantage (VMA) grasping engine that efficiently transforms cable
cocaine addiction in rodents. These objectives directly relate to the mission of the National Institute on Drug Abuse, which is to bring the po
he inability to control these parameter, resulting in islet recovery rates at approximately 55 - 60% of viable cells. The severe shortage of don
toxin drugs. Provided that effective inhibitors of epsilon -toxin are found in this feasibility study, in Phase II we will utilize our initial testing
iated with sleep deprivation in healthy subjects and to provide a biobehavioral assay that identified those Individuals most and least susc
g and improving MAD titration, and 4) develop a model for predicting treatment success with oral appliances. The result of this effort will b
works by providing a small amount of airway resistance during spontaneous inspiration, thereby creating an intrathoracic vacuum that draw
ed blood spot or fresh blood will be the input to the system and it outputs the screening results in a completely automated fashion. Ph

s with which to make phone calls. Recently, several manufacturers have released models that play videos as well as provide a very capable
as been recent interest in the use of the electroencephalogram (EEG) to screen patients and identify the first signs of AD. There is extensive
ntervention is necessary. The availability of technology that enables effective, timely, and reliable information transfer between the homec
f lost productivity. Nearly 80% of all adults experience low back pain at some time in their lives.2 Many people experience their first episod
e it is recorded. Personal area networking technologies, such as the Bluetooth network, are now standard in many commercially available h
and power sourcing into a very small electrode package. An electrode package held to the skin by adhesive will be able to transmit the data
benefits are made available to the visually impaired community without requiring expensive building infrastructure investments. This is of p
dwidth allows UWB to transmit large amounts of data. One of the most common neurological diseases is epilepsy. Epilepsy refers to the ten
verexpressing GP88 are resistant to current therapies - Tamoxifen, Faslodex, doxorubicin and Herceptin, 5) increased GP88 expression in bre
tic markers and drug targets into the assay panel. There are several anticipated advantages of the layered membrane platform over current
CLC- associated protein markers. The overall purpose of this application is to prepare microarrays of a panel of peptide targets and to dem

odest 10 fold reduction in RCA frequency over that seen in 293 cells would provide a robust production system if the vector productivity w

potential toxicity of the combination (the subject of this Phase I application). The long-term goal of the research described in this proposal
ch program. In the Phase II program the spectral region for simultaneous CO and OCS detection with a single laser will be identified and las
134a than for carbon dioxide. Aerophase has developed an inexpensive carbon dioxide (CO2) propellant MDI that is competitive with the H
e first step, supercritical carbon dioxide extraction of Artemisia annua leaves, is known to isolate artemisinin and artemisinic acid in high yie
to identify therapeutics which affect the identified pathway and which have been tested in man, but whose mechanism of action has not b
mice based on electroencephalogram (EEG) and electromyogram (EMG) sleep detection. Afasci, in collaboration with Stanford University, ha
o create an instrumented homecage, termed the SmartCageTM. Researchers using the SmartCage can conduct behavioral cognitive testing
eutic biologic agents (cells, serum proteins, growth factors, etc.) to native surfaces (cells, extracellular matrix, tissue-specific proteins, etc.).
to decrease implant colonization. We initially targeted vancomycin for "proof of principle" because it has a significant amount of structura
osteoinductive, they could provide an unlimited source of graft material that would eliminate many of the drawbacks of autograft, allograft
of bone and soft tissue (Caplan and Bruder 2001). Interfacial biomaterials (IFBM's) will be synthesized by chemically crosslinking combinati
tain disease conditions that produce characteristic gait abnormalities such as Parkinson's disease. The goal is to prevent falls and thus redu
 he mouth. During these guided tissue regenerative (GTR) procedures, barrier membranes are positioned between the surgical fap and the
stly recombinant biologic adjuncts already in the marketplace. The development of a safe, effective, and useful product for periodontal bo
eir handheld computer, while a central simulation gathers all the data and projects them. Collective Simulations allow students to learn ab
a storage and analysis subsystem. While the device platform will allow the inclusion of different sensing elements, the project will focus on
ModelTalker. In particular, our specific aims for Phase II are: Aim 1 - Enhance the usability of InvTool. We have identified several specific im

pheral side effects without inhibiting analgesia; (ii) comparing the opioid withdrawal precipitated by the neutral antagonist to other antagon
tronic data capture of case report forms (CRFs) and patient diaries (ePRO, or electronic Patient Reported Outcomes). Improve research ma
he synthesis and characterization of biodegradable cross-linkers. These cross-linkers will utilize a biodegradable spacer. The materials used
or anti-viral therapies either in the clinic or in the field within 20 min of sample acquisition. We will meet these objectives by taking advant
ptase, multiplexed, microarray-enhanced polymerase chain reaction (RT-MME-PCR) amplification protocols on the Akonni gel element arra
id channels. The system we envision for Phase I will integrate into investigator-optimized culture platforms. We will develop and test and re
hoton counting Geiger mode avalanche photodiodes. The proposed detector would incorporate the high throughput of the CCD detector w
with very high sensitivity using fuorescently label monoclonal antibodies. This high sensitivity is achieved by the placement of the photon
mission in the wavelength range that is most suitable for CCD-type devices, and orders of magnitude higher radiation resistance than curren
l sciences are obvious, the scope of such studies is limited at present by the available neutron detectors. The goal of the proposed project i
(i.e., due to physical injury etc.,) using a non-invasive imaging technique. Radiation Monitoring Devices, Inc (RMD) in collaboration with Dr.
es. Thus, the availability of a practical, cost-effective, quality assurance technology could help prevent future illness and deaths from lead p
n experiments on polycrystalline alumina, which is similarly anisotropic, and is being developed for optical window applications. It is the aim

g tissue vascular physiology and perfusion in organs, as well as by conducting functional physiologic studies in small animals. This new ima
rdiac care and clinical diagnosis. However, there is urgent need for improvement in the performance of these imaging modalities in order to
PET signal. The integrated system will open up a number of opportunities not possible with current independent PET and MRI scanners.
used in macromolecular crystallography and neutron radiography. High resolution neutron imaging will provide better insights into biologica
proach-we are focused on finding all the facts. We call this "total recall" which we demonstrated was possible in Phase I but total recall com

acture commercial products.

ection allow for easier manipulation of large numbers of samples, they require several washing and centrifugation steps, and involve very e
delivery method. Oral delivery of drugs is usually the preferred administration route, however the oral bioavailability of CBD is only about 6
over time under these conditions will be measured, where efficacy criteria include biofilm inhibition as well as nonthrombogenicity. Proto
ervative estimate of well over $1 billion per year in the USA, mainly by reducing the number of False Positives that are biopsied. However, e
ped and shown to localize in the nuclei of melanoma cell by fuorescence imaging. The goal of the proposed research is to determine the e
to produce thorium-228, a precursor isotope to Pb-212. As a result of implementing this Phase I grant application, Ac-227 will be separated
nced Common Path Interferometry platform especially for this purpose. Phase I project will pursue the following objectives: 1. Design and p
r mass-tags (PC-CODE). We propose to extensively optimize and evaluate this new technology during Phase II with the aim of commercializ
t goals were achieved including: i) Elimination of proteolysis of expressed polypeptides, ii) Demonstration of the ability to detect drug resis
DNA samples (stool and tissue). All of the goals of the Phase I project were achieved including: i) Demonstration of the ability to scan the co
ming these limitations by developing a cost- effective alternative to conventional PTT. One approach utilizes an ELISA-based protein truncati
nd fat metabolism, and oncogenesis. Indeed, tumor-associated, differentially expressed miRNAs, termed "oncomirs," have been found in m
for these diseases is becoming evident, and mutation-specific inhibitors become available, classification will need to include molecular ide

ed KOR. However, the methods and detergents developed herein should be generally applicable to other brain-derived GPCRs. The results
at one or more hospitals and test it for an extended time, to demonstrate a reduction in nosocomial infections. In Phase III we plant to com
equent vomiting and leads to a very low quality of life for those who suffer from its effects. Currently there is no adequate treatment. An e
mprising phage display, 3-dimensional molecular modeling, protein chemistry and preclinical biology, we have identified Ang 1170, an organ
 l molecule SF/HGF mimetics oppose interstitial collagen deposition and preserve renal function. Preliminary data from regulatory safety stu
ge display, 3-dimensional molecular modeling, we have identified Refanalin, an organic small molecule SF/HGF mimetic that could serve as
-Met activation and inhibit down-stream signaling events initiated by SF/HGF. We found that ANG 797 also targets another receptor tyrosin
on of Hepatocyte growth factor (HGF) gene to the bleomycin treated mice prevented the development of Scleroderma and lung fibrosis. W
sine kinases that have been identified as therapeutic targets against angiogenesis. Using a drug discovery engine, Angion identified the sm
ule, Refanalin, that recapitulates the biologic activity of HGF/SF by activating the HGF/SF receptor, Met. Our working hypothesis is that Refa

necrotic malignant tissue but has little effect on normal tissue. The A1 bacteria eventually disappears from normal tissue even in immunod
e will not only directly benefit drug development efforts, but will also provide critical information and reagents to a rapidly-developing field
e efficient bioprocess for human insulin would be immediately useful. This novel, rapid, economical, GMP- enabled bioprocess platform for
ompleted in = 10 minutes. Our Phase II aim is to build a robust commercial prototype and evaluate the diagnostic sensitivity and specificity
erapy, both for use as a standalone topical treatment and for use in conjunction with 1,25-dihydroxyvitamin D3 analogs. In the latter case,
-refractory tumor in a mouse xenograft model. The proposed research in this STTR Phase I application includes formulation of 1,25(OH)2D
e proposed research, is uniquely valuable in the pediatric population, given that many authorities believe snoring is never benign in childre
signaling pathways induced by VEGF and TNFa in human retinal endothelial cells. Importantly, we further demonstrated that administration
tasis, and the extensive use of FasL to induce allograft tolerance in various settings, the Principle Investigator of this grant, Dr. Haval Shirwan
utic effect. Various cancer vaccine approaches based on the use of TAAs have been developed and shown effective in preclinical models. H
preliminary studies to have potent immunostimulatory activity for T effector cells and inhibitory activity for T regulatory cells that are imp
the constructs with the ERK1/2 and ERK5 pathways, our Phase II research will involve the in vitro functional effects of shRNA-loaded constr
ties (birefringence) rather than their refractive index difference with the background (i.e. crystal edges and facets). This technology results
nd guidelines for the moderate sedation course. 2.) Develop a prototype outline for the moderate sedation course - The outline will deline
hrough an iterative design process. Usability testing will guide design enhancements. The resulting display will be implemented in C++ prog
thin the PkPd Display to include other commonly used anesthetics, such as inhaled agents and additional opioids. 3. We will characterize d

ury associated with lung transplantation. We will optimize the dose regimen of a clot- targeting apyrase that will provide significant benefit
nventor, Dr. Aubrey Moore, only to the automated laboratory identification and quantification of a few aphids and mosquitoes, and by APT
is of ecotoxological effects at the gene level in sentinel species like sheepshead minnow offer the promise of future ability to tie ecotoxicol
er. By virtue of targeting multiple processes (physical and biological/molecular) in conjunction with laser or electrosurgery, the drug(s)-eluti
trolled study comparing standard verbal informed consent to interactive multimedia informed consent for a cardiac catheterizatio

f precious liquid. An interface between the dispensing equipment and an archived-liquid database application will allow laboratories to con
unique opportunity to bridge the gap between free-text and structured knowledge in the drug development field. We have developed Me
ll as classical non- mucoid strains isolated from patients with nosocomial infections. Preliminary data indicate that these human mAbs reco
man BBB by receptor- mediated transcytosis on endogenous BBB peptide transport systems. Pre-clinical studies show that a large enzyme w
a wide variety of diseases.
y at two partnering organizations: Montefiore Medical Center, Bronx, NYC, and the Institute for Clinical Research at the Veterans Affairs Med
iogenesis for the short term and bring symptomatic relief, the underlying vascular loss that is the initiating cause remains untreated. In add

sied must be firmly held in some manner, much like the area is held by the fingers of an experienced animal technician. Therefore, we also
ats will be used to establish the performance characteristics of the spectrometer hardware, fiber-optic interface, and alarm algorithm. In a
ct are first to isolate biorecognition proteins capable of discriminating between native and OP-poisoned human proteins, then show proof-
erved with allogeneic rat MAPC in the rat neonatal HI injury model. Dosing experiments will include: Aim 1.1: IV dose ranging to determine
nt, we propose to develop a long-acting formulation of buprenorphine that is capable of maintaining analgesia in mice and rats for 3 to 5 d

repeated many times making several copies of the template. PCR is then performed, amplifying the targeted region of the DNA. Because t
some, but not all, of these problems. In this project, an earphone will be developed that 1) minimizes the occlusion effect permitting pure
al products compounds known as cyclic peptides. Cyclic peptides are isolated from microorganisms such as bacteria or fungi. They are typic
permit us to continue with Phase 2 of this proposal where we will test the efficacy of the devices in animal models of sensorineural hearing
loped, in part with NIH SBIR funding, a platform delivery technology for subcutaneous injectable sustained release that has demonstrated p
ecific aims of this Phase 2 project are to optimize the parameters of the formulation, and to complete the necessary preclinical work to app
ptantagonist promotes wound healing and attenuates fibrosis in standard animal skin injury models. However, the use of TGF-a peptantago
s project will now assess the feasibility and reliability of using this radiopharmaceutical as a biomarker for measuring plaque burden in AD p
ready completed (or have in progress) all the necessary IND-enabling studies on F-FP-DTBZ. In this SBIR grant we propose to conduct the fir
ies. The overall aim of this Phase I project is to determine the feasibility of testing nerve allografts in a novel goat animal model which allow
re calcium-activated proteases that are central to the process of axonal degeneration. Axona's long-term objective is to develop AK295 into
as been shown to increase the immunostimulatory properties of BCG, and a pro-apoptosis factor, which we predict will increase antitumor
a sensitive ELISA for quantifying one brain injury biomarker (BA0123) in CSF was successfully developed, and proof-of-concept data confirm
ehavioral dimensions represented in the data. To demonstrate internal-consistency reliability, Cronbach's alpha and item-total correlations
blems noted. Although brain imaging, such as cranial ultrasound, computed tomography, and magnetic resonance imaging, can document
tion of a minimum number of appropriate items. The KnowPain assessment instrument will be tested with human subjects in a validation t

different because it measures early germination events while conventional indicators measure spore outgrowth into a bacterial culture. The

igned to accelerate all stages of BLAST-like similarity search algorithms, not just the final Smith- Waterman stage. Phase I of this fast-track S
CT) of the Windows version with a 12 month follow-up to assess its effectiveness. The RCT will compare the CDCU to a no treatment contro
evaluate a broad breath, limited depth prototype of the program and evaluate its technical merit and feasibility via a pilot study with SMAR
nalyses, the global construct validity and factor structures of the HSI-A immigrant and non- immigrant versions; 2) Estimate the construct va
h major depression. In the event of a successful Phase I test of feasibility, we will substantially expand the multimedia program and its evalu
erative process of development and evaluation; and, 3) Conduct a feasibility pilot study using an RCT design to evaluate knowledge gains in
ative to GTP hydrolysis so that the former is no longer rate limiting. The availability of these novel HTS assays will accelerate drug discovery
ber of the fFCXHTS and validated a single-assay prototype device fabricated from elastomeric polymer. In Phase I, we will show feasibility fo
ding fibroblasts. We will use this mammary tissue model to establish the design parameters of the fF-RTD and to functionally validate it for
mediators for the purpose of cell replacement therapy or stimulation of regeneration of endogenous pancreatic a cell progenitors to treat
ne (PC-3M-luc-6M) to generate orthotopic and metastasized prostate cancer in athymic mice, and use Caliper's in vivo non-invasive imaging

e for older adults and accessible to the broader public for independent use. Innovation: Bio Logic Engineering Inc. is addressing this need by
g. catecholamine release redirecting blood fow away from the liver, kidney and gastrointestinal tract during a pharmacokinetics study). The

ny others. Processes based on these enzymes have proven to be practical and scalable. In 2005 alone, our enzymes were used for the comm
% reliability rate in our first human clinical trial is encouraging. In addition, the average electric field measured near benign lesions (223 mV
We will develop robotics for remote control of the device, custom MR receiver coils, and appropriate control software. By using five position
allow us to ascertain the impact on productivity of such software. Phase I, Specific Aim 1 will complete design of a current scientific practic
y these patients for these treatments. Since repeated tumor biopsies from such patients are often difficult (due to thoracic location of tum
nomiPhi(tm) and Qiagen as REPLI-g(r). Studies based on highly informative microsatellite markers suggest MDA amplifications with small qu
eening. The UF filtration technology developed in this project combines novel fuidic and geometrical configurations that provide higher th
ens (Helicobacter, Campylobacter, Arcobacter, Wolinella), and important colonizers of the colon and vagina (Bacteroides, Clostridium, Lacto
Phase II NIH SBIR program, we have demonstrated the ability of these devices to accurately detect the presence or absence of a suspected
cruitment and overcome the infammatory and ischemic response by modulating undesirable molecular signaling pathways. In this regard,
eres to the abdominal cavity, even under profuse bleeding, when it is injected intraperitoneally through a Verres disposable needle. Our hy
rporate in the software; (b) Developing algorithms and scientific approaches for space-time exposure reconstruction. These algorithms wil
ncidence of cancer morbidity and mortality among minorities and the medically underserved in the United States. Instructional materials w
proaches that ignore residential histories and instead rely only on place of residence at time of diagnosis or death. The major innovation is t
, packaging and biocompatibility. Research and development will specifically involve designing, fabricating, and integrating various MEMS a
assive parallel fashion could dramatically reduce the cost and serve as a basis for consistent, high-throughput genomic analyses in future p
a. (2) Develop a plasmid vector to allow the rapid cloning, expression and purification of peptide antigens fused to carrier immunogens ide
oving that peptides containing these epitopes can be used as diagnostic targets. In this Phase I STTR, we propose to analyze FlaB, several gr
libidum feeding of the natural host reservoir of this spirochete, the white-footed mouse, Peromyscus leucopus. After treatment, we will as
munoassay technology, to directly measure GFR. Our proposed test will be accurate, simple-to-use, inexpensive and will be widely assessab
develop tools that allow researchers to track, identify, and measure the amount of implanted cell in living subjects over long periods of tim
r concentration of gadolinium-DTPA. The synthetic process yields a gadolinium oxide core that is tightly bound to an inert matrix, which sho
re supernatant. However, as TL1A is known to bind to another soluble protein DcR3 that is known to be present in a relatively high level in
ed, PK studies conducted. Second, to evaluate the future therapeutic potential of rhDcR3 to treat septic patients, we propose to test wheth
ology has emerged as a superior alternative to time-domain OCT, exhibiting improved image acquisition speed and robust system design. T
d validation of a field-deployable HIV viral load diagnostic. The specific aims of our Phase II application are: 1. To evaluate the accuracy, thre
biotic erythromycin. The DEBS synthetic DNA has already been synthesized and is functionally expressed in E. coli. (2) Use lsGG to replace a
echanism for eliciting fuorescent signals by direct enzymatic reduction of azo bonds. Our azoreductase cuts azo bonds of our Black Hole Q
ople whether the covariance of action potentials and fast field oscillations indexes the likelihood and origin of seizure. There are many good
ded from the source and target speakers. The amount of training recordings is far less than what is needed for a high-quality acoustic inven
nt. Our second aim is to fully characterize these microfora communities by pyrosequencing mucosal, lumen, rectal swab, and stool sample

porary Black radio. The emerging technology of web casting, made possible by the Internet, will, in addition, allow us to test another poten
urrent technologies. The resultant dry power aerosol, of 3 fm aerodynamic diameter will be delivered at inspiratory fow rates of 20-30 l/m
xtures and determination of their relative abundances. Finally, pathogens can be identified against an uninteresting background of commen
g tasks: I. BioTex chemists and collaborators Dr.Stephen Massia and Dr.Fred Clubb will design, test, and optimize suitable chemical protocol
ns. Disruptions in this process play important roles in many major diseases such as neurological diseases, cancer, autoimmune diseases, dia
so that compounds of interest maybe applied to the cell. A failure of anyone of these steps will result in no data collected from that well. W
ype a commercially viable consumer version of the Smart Telescope. The Phase II work plan has four tracks: 1) User interaction and interfac
data and simulation based upon a simplified joint model. Specific Aim 2 - Develop electromagnetic tracking-compatible tooling for TSA nav
PEGylated muteins for further testing in animal models and identify the optimum PEGylated interferon-gamma cysteine mutein for comm
of sFlt-1 that were believed to be non-essential for biological activity. The "free" cysteine residue served as the site for the covalent modific
ction, and will be integrated into a proven adaptive optics scanning laser ophthalmoscope design. Adding the optical doubler to the system
demonstrated that the CO2/O2 ratio >0.45 has diagnostic sensitivity and specificity at least equivalent to the quantitative D-dimer 0.45 or
tion and encrustation of stents and catheters. One technique for producing antimicrobial surfaces is to apply a coating which is capable of r
a sustained anti-caries therapeutic effect. With the Phase-I funding support, a new class of S. mutans-selective molecules, called specifical

are performed in solution. Caldera Pharmaceuticals, in collaboration with Los Alamos National Laboratory (LANL), developed Reagentless P
as arsenic, cadmium, lead, and mercury (thimerasol), as well as exposure to essential metals (zinc, iron, selenium, etc.). Individuals with au
a customized EDAX Eagle III MXRF spectrometer and a customized EDAX Eagle II MXRF spectrometer and Horiba XGT 5000 XRF microscope
ence in implementing high-throughput drug discovery screens. Dr. Morimoto is a leading expert in the field of protein dynamics and homeo
-throughput screening (HTS) protocol and secondary assay screening tree for identification of inducers of DJ-1 expression. (2) Identify induc

measure salivary osmolality in the laboratory setting. The goal of this Phase 1 research project would be to develop a stand-alone unit capa

ient animals-to enhance the commercial potential of this strategy for heart repair. The Applicants' Specific Aims are to: 1. Assess the hu
tibodies to improve the specificity and potency against lymphoma cells. Towards this goal, the proposal is structured into 3 specific aims: (1
ermine absolute cerebral SctO2 with a high degree of accuracy in the adult human. We hypothesize that our commercial absolute cerebral
g its efficacy (DVD 2). The goals for this Phase I SBIR Project are threefold: (1) to recruit practitioners (n=50) who have attended a BASICS W
us, in this proposal we would like to test if HUCBC infusion can promote a rescue of behavioral and cognitive deficits and correlate these ch
abetic mice. The recipients will be evaluated for the appearance of human C-peptide, human insulin, changes in blood glucose levels, and b
elopments should have an impact not only on the quality and availability of lung tissue samples, but also enable expanded utilization in ar
) applied in specific locations of the diseased area; (3) The application of will initially be intended as a salvage therapy tool for treating pros
d to provide varying levels of zonal (thermal) protection; (4) The utilization of this device will be an effective nerve-sparing agents and may
e peptides from several cancer cell lines. Modified peptides will be isolated by a variation of the immunoaffinity technology we developed

om PhosphoSite(r) into pathway visualization programs that allow users to explore the rich regulatory interactions that are described in Ph
ercialization of a microfuidic cell culture array to predict drug compound toxicity in clinical trials using human hepatocytes. The successful
compatible with this HTS technology of peptide leads. The technologically simple and cost-effective approach of cell- based HTS with pool
Institute (TSRI), we will subsequently validate this library in a simple cell culture-based model, to identify genes responsible for the growth
for 20,000 human genes selected from the RefSeq database. In collaboration with our bioinformatics consultants at University of Rocheste
hesis has been established by our preclinical models of myeloablative radiation injury in which we have demonstrated that a single infusio

on of these technologies in developing countries. We have now developed a virus capture reagent - magnetic particles coated with a chem
tablish genetically modified hESCs that will enable the purification of a relatively homogeneous population of ventricular CMs and 2) to val
ology objectives are to develop and optimize the sensor technology required to make the chemical identifications within the parameters al
nanoparticles loaded with Raman reporter molecules have extraordinary attributes that make them ideal as biological detection tags. For
5 MHz and above, develop via machining to allow for 2-D elements, and optimize photolithographic methods for multilayering of crystals. In
nsducers. For the Phase II program, TRS proposes to build on these results by constructing an IVUS segmented annular array with broad ban
demonstrate the feasibility of creating differentially-glycosylated ketolide libraries for the identification of anti-infective leads via the synthe
s and comparison of their cytotoxicity towards cancer cell lines and inhibition of the Na/K-ATPase transporter in the cell based assay will th
old storage of donor pancreata. Here we propose a complimentary study to address the second important factor for further development o
her. Each year over 1.5 billion Complete Blood Count (CBC) tests are performed in the United States. The CBC is a critical component of pati
EA for commercialization by repeatedly assaying a set of 78 reference test chemicals to confirm the reliability and accuracy of CCi's propose
clinical trials in humans demonstrated the side effects and dose-limiting toxicities of CA4P. Thus, new CA4 analogs with improved anti-angi
OUHSC), and relationships with the Dean McGee Eye Institute and the OK Medical Research Foundation. The market size for neovascular
ee of these analogs, Compounds 1, 2 and 4, have potent anti-angiogenic activities. Moreover, these analogs block the expression of retinal
nostic test for human leptospirosis, based upon the innovative proprietary lateral fow technology (DPP, Dual Path Platform) of the investiga
w sensor relies on an array of specific capture probes bound close to electrodes and surrounded by microactuators that assure confined an
new inhibitor identified in the screen, using our collection of yeast gene-replacement strains carrying different ACCs, and to confirm ACC as
er module for the application studies using drinking water. This project will explore a novel technology that can be applied to the remediati
al in Phase I is to assess feasibility of detection and quantitation of these candidate biomarkers, and to develop optimal test conditions for
o treatment of other social groups and disorders. In Phase II, focus group studies and validation studies of the efficacy of the TEACH system
lary blood sampling). Such real-time measurements will be crucial for the ongoing monitoring of disease progression as well as the evaluati
osts. The proposed system will consist of three key elements: an instrument, a protein chip microarray cartridge, and pattern recognition so
nology with an automated fow cell detection and analysis system. The innovative approach of this project will combine MHC-peptide array

vasive, easy to use system of small, lightweight, wirelessly networked modules to quantify multiple PD symptoms. Modules will include mo
This is particularly true for three large families of CNS drugs, antineoplastics, antivirals and antiepileptics. Studies performed in small anim
ontent, skill-building activities, decision-support tools, peer support, and resources. It will be a centralized, organized, interactive resource u
ency Medicine Fellowship at Rainbow Babies and Children's Hospital, the overwhelming response from the Emergency Medicine Residents
and analytical chemistry and 4) Further determination of ADME and toxic properties of CDD- 0304 and analogs. These studies, with some a
aboratory has demonstrated that Tg-SwDI mice exhibit robust neuroinfammation that is strongly associated with the cerebral microvascula
ecific Aim 3: Using a DSS model of chronic colitis, measure the response to treatment with different doses of COG112 using clinical outcome
playing a critical role in the age of onset for development of PD. In addition, ApoE has been shown to have significant anti-infammatory eff
ndrome induced by both gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacterial species will be evaluated to
display therapeutic efficacy in EAE models of MS. With support of preliminary data in a pilot study, we propose to examine our lead comp
ablished models of MS. In specific aims 1 and 2, we will identify the optimal candidate from the three COG compounds in myelin oligodend
ll bone fractures. To test this hypothesis, the following specific aims will be accomplished: 1) Optimize the physical characteristics of uncure
gn. To test this hypothesis, the following specific aims will be accomplished: 1) Optimize the physical characteristics of the tissue adhesive f
juvants 1) accelerate the development of T-dependent antibody responses to infuenza vaccine injected into mouse skin; 2) elicit the same
m four L1 backgrounds. Based on the assessment results, a training module will be developed and a training study will be conducted. A nov

am. This participation will enhance overall chances for commercialization. In Phase II we will first fabricate high fux composite membrane

h border membrane vesicles (BBMVs) which express these transporters. This will enable us to examine the structure-activity relationship of

be performed either in the sound field with loudspeakers (SF tests) or by direct connection (DC tests) of the instrument's outputs to the aux
hort pulses (~ 100 ms duration) of supersonic beams for mass analysis. This will reduce the load on the vacuum pumps that are normally us
search Council, 2001; U.S. Bureau of the Census, 1996). Despite the enormity of this public health problem, many individuals with chronic p
e using advanced numerical methods, and formulate numerical solution strategies. (2) Implement the approach in Aim (1) and conduct pre
der composition and film thickness. Solder biostability is increased by reaction with a standard cross linking reagent. The specific aim for Ph
stal material to be used, ferroelectric liquid crystal, has shown a full spectrum tunable notch filter with bandwidth
RP-01) was built using Phase I STTR funding, and was shown to be mechanically robust, easy to place and use, and able to successfully tran

ew items to broaden the range of coverage and fill in identified gaps, conduct a field study to re-calibrate items, create algorithms for a fully
s, and professional staff-will provide guidance on their concerns and issues on the usability of lifters, evaluate design drawings, and then ev
age and comorbidities; 2) Improve resolution by using an expanded history of risk factors; 3) Begin to build patient trust by detecting selec
are: 1) to modify and instrument a TRS4000 device for interface to a proprietary 2-channel adaptive stimulator; 2) to develop NuStep-spec

moglobin sensor that incorporates the most current, state-of-the-art, inexpensive, reliable, and long-lasting light sources and detectors, (2

uccess by pursuing the following specific aims: (1) expand Cell Xpress utility to an additional cell line and therapeutic (non-antibody) protei

ouch model in an immunodeficient rodent. The combination of these emergent regenerative medical technologies is expected to provide a
ted with Enhanced Green Fluorescence Protein (EGFP) that will be used to measure the lysis of target cells. These tumor cells cannot be lys
re an exciting first step in the development of non-narcotic pain therapy. The very important identification of a new CYP gene with selectivi
um. However, while endothelialization and capillary growth and regeneration are important and valuable, many clinical problems need a m
to simply arrange for the large protein molecule to tumble as a much smaller protein. This is achieved by encapsulating the protein in a rev
with AS/HFA who has successfully transitioned into post-secondary life. The proposed product will include a facilitator's guide, student wo
iculum that is effective and appropriate for use with diverse populations of adult substance abusers; 2) Provide treatment and training mat
er stakeholders about TTM and provide them with tools designed to help their patients/clients obtain treatment for this disorder. TREAT wi
ers, psychiatrists, intake workers) by educating them about the range of barriers these families face and enhancing their engagement skills,

e the program; (2) counselor, participant, and family materials for 12 core client sessions that include motivational engagement techniques
 The difficulties for such models such as GLMM is that estimation methods often have troubles to achieve unbiasness, consistency and effic

on all of which can impede adherence. Absences from school, being teased, keeping their illness secret, and lack of access to peers with CF
aims of this proposal are to: 1) Develop the complete content for the Living with Borderline Personality Disorder educational video series fo
1) a Teacher's Guide with gender-specific instructions and activities; (2) a video program; and (3) an interactive CD-ROM. In Phase II of the p
ngle Institute (RTI) to complete the pre-clinical development, prepare the IND and ready the products for a Phase 1 clinical trial. Prior to th

and an ability to update training materials. This product re-creates the training program in the Spanish language and culture. OUTCOMES:
vels. These estimates will draw upon a variety of data sources, including: Remote Sensing data, GIS information (such as elevation, land use
ages of MIS. The commercial potential for such a system is very high because of patient desire for the smallest and least invasive surgery po
nors from alcohol. The program will also inform young women entering their child-bearing years of the risks of fetal alcohol exposure. Gree
b-based training program which will increase the capacity for the delivery of eating disorder secondary prevention among oral health provi
nding of correlations between molecular features and efficacy of bRCQs against malaria, the bRCQ structures will be "tuned" in order to op
ate a data delivery system that allows users to define an area and select their own reports. A plan to market the product to a broader range
med at a PMA submission to the FDA will be carried out at two sites in the U.S. and one site in Italy. Because of the usefulness of the DRW H
chnology have successfully focused on a model system. However, the capabilities of DCP for diabetes biomarker discovery in patient plasma
DCP will play an important role in medicine and biomedical research wherever biomarkers are involved, including disease diagnosis, the m
V/AIDS medications over time. It is expected that this system will engage patients more with their care and become a robust model for patie
e II study, SPIMA will be validated with a larger patient population through a phase IV clinical trial. It will also be applied to run off a mobile
ch will be lost when a drug blocks the interaction of the kinase with its allosteric regulator. Feasibility assays will focus on developing a cell-b
ection system by mutating the ProLabel peptide to create a weakly complementing a-gal fragment termed ProLink. Because the system com
fic for hepatocytes and construction of a plasmid, pKLAT2, that contains an SB transposon plus multimeric LexA operator sites to which the
ipated efficacy of SB-mediated gene therapy for FA. In this regard, there are two key questions that will need to be addressed; (i) What is th

ution to two distinct requirements: protected exposure monitoring and enhanced communication at the workplace. Since each worker dow
model nematode Caenorhabitis elegans and the filarial parasite Brugia malayi were utilized to successfully identify and prioritize a small set
focus or to enable extended-depth-of-field imaging relevant for cytology slides. The Phase I project emphasizes development of a novel liq
mbines the efficiency of BLAST with the thermodynamic rules for hybridization. In this Fast Track SBIR application we propose development
nuous process for gel production D. Optimize radiation sensitivity, resolution and accuracy of the gel dosimetry system. E. Obtain outside fe
minant will also benefit from Cry- oMR coils, such as extremity bone marrow evaluations in children, where MRS (1H, P, and C) may prove 31
be with order-of-magnitude reduction in rf sample heating and more than a factor of two improvement in each of the remaining three mo

hip, specially designed for compatibility with HgI2, to the intraoral Dental application. We will measure the performance of the prototype d
nning events according to x-ray energies, and spectroscopic x-ray imaging capabilities. These new features lead to: potentially significantly

of dynamical autoregulation. 2) To validate autoregulation measurements derived from the MMPF using BP-BFV responses to these physiol
w level of accessibility to as- yet-undiscovered antibiotic agents. Success will provide new antibiotic compounds to be used in the contin
ween diamond carbon and workpiece (e.g., steel) is one significant tool wear route. However, the current technical solutions have not expl
ers and clinicians, such as isotope dilution, dual energy x-ray absorptiometry, air-displacement plethysmography, total-body electrical cond
ecific toward particular sites within proteins, ECI was able to design a single target peptide that contains cleavage sites for proteases from th

oxin deoxynivalenol (DON) and other mycotoxins such as fumonisin B1, zearalenone (ZON), and afatoxin B1; (2) Characterize and optimize
l protective compound to the gingival pocket. This compound is a novel inhibitor of microbial and infammatory proteases from a class of "P
ood size preclinical test, posing a severe financial challenge to thoroughly investigate of the HIV inhibitory properties of SLPI. In this STTR pr
states. Studies have shown that osmolytes can be segregated in categories of folding osmolytes and anti-aggregation osmolytes and we ha
e and high school students with HID. The feasibility and validation studies will focus on (a) usability of the program, (b) student knowledge
A method could allow the ability for routine sequencing of the human genome. In theory this system would allow a 3 billion base mammali
nto a nanopatch device capable of measuring single channel currents. This device consists of a new membrane configuration comprised of
s and museums. Science activities in all proposed SciPacs(tm) and Sci4Pacs(tm) will be evaluated for safety, shelf life, and affordability for p
instrument with keyed sampling chamber that ensures the SERS sensing elements are automatically aligned into the system. The compact
nalyte premodification or sandwich formation with a labeled secondary antibody. Furthermore, the method is capable of single molecule se

sed MI, of the PIM method to provide a reliable viability maps in the canine model of reperfused MI. PIM was also compared with the curre
l of our system is high given the large and increasing incidence of children with special needs treated in school environments. Health benefi
far greater than that of organisms grown in the laboratory. Microbial populations in soils are >99% composed of species that have never be

de online and CD-based training in four specific sets of activities that will help individual service deliverers effectively implement interactiv
end estimates, and d) outputting information in clear understandable tables and graphs. EMT proposes ameliorate this crucial capacity bott
to communicate more clearly will facilitate conversations between users of AAC devices and the others in their worlds, and thus increase th
g and staining); and will require considerably less time than conventional techniques. The goal of the work is to design, fabricate and evalu
apid gelation within the vasculature, (iii) adhesiveness and cohesiveness to tissues that allow for vascular occlusion but minimize the risk fo
t the limitations of the liquid embolic agents currently available for aneurysm filling. The hydrogel properties and composition will be furth
proof of principle" microscope will be constructed in Phase II. Biologists have a need to image whole biological cells both at high resolution

cial microfuidics card technology for use in a portable exposure monitor. The University of Washington will develop specific assays that can
will be tested in the field with selected stakeholders in the drinking water distribution system arena. The new prototype technology will be b

andard psychophysical tasks used by scientists, as well as in engaging 3-D animated mini-games that rely primarily on performance of these
ndividuals sensitized to the D antigen. For this reason, and because of the concern over the use of blood-derived products, alternative thera

aller than IOS on identical measurements. Existing competitive commercial Pulmonary Function Testing (PFT) devices include spirometry, fo
derive at least 20 putative rbES cell lines upon completion of the Phase I study. In Phase II, we will work to validate if these rbES cells can co
bition of the intrinsic coagulation pathway resulting from PK inhibition. Using these assays, we have demonstrated that inhibition of PK is m
a substantive increase in throughput of the screening system. Accordingly, Aim 1 is focused on increasing the multiplexing capacity of the a
project is to generate highly concentrated nanopolyplexes and evaluate the ability of this novel, polymeric, non-viral carrier to deliver the I
preclinical trials proposed for Phase II. All 3 Phase I criteria were met as topical application of lacritin in a rabbit model (1) increased tear f
in isoforms from two genes, Bcl-x and CD44; and iii) demonstrate the quantification of isoform levels for Bcl-x and CD44 from cultures of h
n US $1.00 per test. This assay cost estimate is partially based on two assumptions: 1) all reagents for the assay will be developed in-house
ction of stimulated immune cells. Next, we will determine the protective efficacy of the optimized TB vaccine against the standard bacilli Ca
munodominant T-cell epitopes in FVIII that are responsible for its immunogenicity, (2) strategically modify those epitopes using point amino
throughput for chirality measurements in drug discovery when hundreds of drug compounds are being screened as drug candidates, can b
e, methanol, toluene) that may interfere with alternative technologies used to detect ethanol in breath. Using novel breath handling techni
siderable expertise in the detection of drugs in exhaled breath and are knowledgeable about the properties of candidate "taggants" and th
at will be endocytosed by foam cells so plaques on arterial walls can be imaged using conventional MRI. Our long term goal is to develop co
be used to quantify the phosphorylation levels of the immobilized molecular markers. The phase II program will focus on expanding the nu
g adipose tissue that was delipidated with mechanical force, provides the support for this application. Ultimately, we envision a clinical syst

this Phase I SBIR are to determine that FAS derived from human cancer is selectively phosphorylated and detectable in the serum of cance
s the erythromycin producing organism, S. erythraea, that has been the subject of over 50 years of intensive genetic and biochemical resea
products to reduce the cost of production. Metabolic engineering has as its primary goal the rational application of genetic and bioche
measurements of UCBf will be compared to clinical measurements of total serum bilirubin and peroxidase measurements of UCBf. The sec
eptides. Based on our data from treatment of acute wounds as well as preliminary data from wound healing in diabetic C57BL/KsJ-m+/+Lep
proof of concept showed that this combinatorial chemistry architecture met the novel specifications when the target was DNA. The Phase 1
s such as a finger pick of blood, urine, mucous, saliva, etc. Currently, such testing takes hours and is often done with individual tests. AIR is c

ection system. Sehda will transcribe the recordings and use the data to build language and translation models. (3) Sehda will then build the
y of collagen cross-linker formation as it develops in the region around the chondrocytes. Once successfully demonstrated, these capabilitie
s derived from automated synthesis. General procedures to purify and analyze carbohydrates synthesized by automated protocol will be de
o further develop our single-cell electroporation platform, making intracellular delivery a well-controlled, highly efficient, and parallel proce
s SBIR project is to offer, via a state-of-the-art website, everything school staff need to engage in an innovative and proven sequence of asse
d information concerning valve function to the physician and/or patient. A data collection system will also be constructed to record and doc
ermissive cells, one gene perturbed in each cell, and then screen for cells that acquired resistance to HIV-1 infection as a result of RHGP. W
coils have no more than 8 channels. Perhaps the biggest challenge in building these complex RF circuits is the size of the preamplifiers to b
screening tool to better define the population most likely to benefit from androgen therapy. Currently there is no known diagnostic availab
ese racemic mixtures are active in preclinical tests predictive of antidepressant activity. A U.S. Patent has been issued on these compounds
 ite materials, to ensure the AMM microstructures can be manufactured at full scale and low cost.

using the familiar MATLAB platform, the same toolset used to develop and refine the DSP algorithms in the conceptual design phase prior to

ut the interceptor fyout.

mputation strategy; Route Adaptation strategies with changing MANET behavior and deployment environments.

ng miniature, lightweight, low-power radios will reduce communication failures while maintaining a robust, fexible system for reliable comm

monstrates the scalability and technical feasibility of our tool implementation strategy.

ospheric Measurement System” (ADAMS).

will culminate in a high-quality proof-of-concept design, testable prototype, and quantifiable performance results. The approach will also p
mmercial-off-the-shelf (COTS) Micro-Electro-Mechanical Systems (MEMS) technologies. It will be extensible and allow for future anticipated
gned during Phase III for robust detection of tsunamis, bathymetric features, and subsurface mines from airborne and/or orbiting platforms

wings with available solutions and measured data. ZONA plans to work closely with AFRL in Phase II.
ultaneously then make average and subtraction to get the relative defection basin and eliminate the errors from pavement unevenness, tr

spear in order to decrease the total stopping distance and move closer to the goal of 9 feet. A detailed system dynamics model will also be

n, fabricate and validate the BICS solution set.

be evaluated under an ONR FNC program. The system developed under the Base project would be tested with this hardware. Under Opti

emented as a straightforward add-on process with little or no impact on the conventional manufacturing fow.

a variety of environments.

to commercialize the SEHB technology after the SBIR Phase II.

vided by AFRL-WPAFB, Goleta Star can collect nonlinear SAR-MTI data with its Ka-band UAV radar, even during Phase I.
sential Tasks. This methodology will be tested in the Gulf of Guinea.
f solid-state Li+ conductors in the battery through interface engineering.

project management will be provided by Photon-X.

s rapid development and deployment of high-level PHM algorithms on this platform

ons not adequately covered by existing simulations models such as PEELS.

preliminary, and detailed analyses and for different physical domains are supported. It enables the coupling of analysis models and design

V platform under urban outdoor conditions involving groups of five or more targets.

with minimum service disruption.

This research demonstrated that RFID sensor tags have the potential to: 1. monitor the condition of sensitive medical shipments in transit;

ission applications include the Mars Sample and Return (MSR) mission, a number of proposed Mars Scouts, and any of the Discovery or lun

urface net pens.

 to separate the digested manure into liquid and solid fractions. The manure is treated through a series of steps that will significantly reduc

hality becomes apparent. Additionally, the expression signatures of the binary mixtures of the three chemicals will be examined and compa
I proposal in which the synthesis and use of the protein will be demonstrated at a pilot scale. This technology has the potential to dramatic

omic biodiesel manufacturing operations.

ng commercial membranes have been identified and evaluated using a bench-top unit simulated the fue gas environment. We were able t

al cost, with expected zero impact on the current ultra-low operational and maintenance design.
 where acute lethality becomes apparent. Additionally, the expression signatures of the binary mixtures of the three chemicals will be exam

with a Phase II proposal in which the synthesis and use of the protein will be demonstrated at a pilot scale. This technology has the poten

with expected zero impact on the current ultra-low operational and maintenance design.

economic biodiesel manufacturing operations.

ng commercial membranes have been identified and evaluated using a bench-top unit simulated the fue gas environment. We were able t

ary adaptations and modifications to address the challenges associated with a multiplicity of operational and transitional states and the pot

m for Tefon and kapton. High tensile strength has the potential to reduce harness weight by reducing insulation thickness. Finally extrusion

monstrations with government and industry primes.

This combination of technologies and experience should result in a significant advancement in see-through situational awareness sensor te
ensation.
ject is to prove the feasibility of the proposed design approach through demonstration during the first phase. Additionally, design and ana

ection augmentation.
ing tools, we will iteratively refine the distributed simulation and supporting toolset.

amounts of electromagnetic field and particle data.

er Benefits as described by the awardee: These measurements could quantitatively link the existing global network of near-surface greenho
he Amerifux network currently has 89 active stations in six countries. An improved CO2 and CH4 fux monitor deployed at these stations w

nd experimental demonstrations.

tremely fexible tool.

borate directly, leading each user group to redevelop software already available in the other user community.

ensor and fusion-capable assets to execute each ISR mission.

) . OC-ALC will provide access to source data and resources to verify and validate processes, Siemens UGS Software will provide Teamcent
O environment.
t and gentle backwashing. This Phase II project will cumulate with the development of a commercial PolyGeyser® Denitrification Filter emp
with fish. Additional markets for our device include the aquarium industry, waste water treatment, water bottling, and drinking water supp

nd techniques to monitor oocyte development and improve the timing of ovulation and fertilization. Improved survival of hybrid catfish em
hives for remote management of colonies. This technology could revolutionize beekeeping, in the U.S. and worldwide.

useful Fe supplement/fortificant that is anticipated, its availability as a food-grade substance and low cost should position it for distribution
otz, Department of Coastal Sciences, University of Southern Mississippi to provide samples from his shrimp infection model system and Dr S

easured by clinical signs, lesions, and viral load. We believe that a novel competitive PRRSV product would generate rapid market share gro

interface, coupling the optimized metalized FEP container with sorbent tube volatiles collection: enabling near-source volatiles collection b
s of three major utilities (SBC/AT&T, Comcast, Consumers Energy), demonstrated the feasibility of the proposed network.
 sor, Integrity Monitor

ses used to keep track of the sources in the institution.

ing based on semantic distance, remote administration, feedback and quarantine of denied transfers, crisis override and an easily configure

ividual & command center graphical user interface concepts for demonstration of the concept will be delivered at the end of Phase I.

mical analysis techniques will then be fused by an ME-based fusion algorithm. The fusion output will be a set of probabilities of the suspect

sor, Integrity Monitor

t neutron sources at NSTs Andrews facilities.

pplications.

In Phase II POC plans to develop and deliver the working engineering system for extended testing at an environmentally contained govern

world, as well as the means for capturing new biometrics data in the field.

through the valve. Phase II studies will be primarily concerned with optimizing the design of the polyurethane replacement valve, and com

systems perform standard imaging capably and are compact, low cost, and maintenance free. This proposal will combine the technical expe
nd treatment and will target home health aides (HHA), nurses and other supervisory personnel, and, to a lesser, but no less important exte

rounds of amplification.
dels and their feedback will be incorporated into the design to be tested to the ANSI/RESNA standards. There are a wide variety rigid backre
 for similar compound retrieval, diversity analysis, and substructure mining will be compared to competing techniques based on other repr
urvey of Income and Program Participation for adaptation to the HRS/SSA link; (2) synthesize a few variables from the HRS/SSA link and tes
ve guidance for minimally invasive surgery and iii) Combined imaging and therapeutic ultrasound applications. The Phase One effort has th
mounts of compounds in 96-well microtiter plates. This will allow us to identify lead small molecules that would counter retinal cell death un
all goal of this multi-phase SBIR project is to develop, validate, and commercialize Ocuscreen(tm), Acucela's proprietary retinal culture scre

accomplish eight specific tasks: (1) establish protocols for data access and privacy, satisfying the confidentiality requirements of Census an
s with CMS for adding the MDS and parts of Medicaid enrollment and claims files to the data inventories of MedRIC; (2) develop an approa
a sulfhydryl for attachment to the metallic nanoparticle surface; 2) to develop and evaluate the use of miniaturized microwave radiation en
fficiency of glycan analysis and meet the growing needs of glycomics research and biomedical applications. Glycomics study the interactions

that efficiently transforms cable excursion and tension into quality, stable grasp. This engine significantly improves the ratio of grip force ac
ug Abuse, which is to bring the power of science to bear on drug abuse and addiction, by targeting drug development for cocaine addiction
cells. The severe shortage of donor organs. The need for long term immunosuppression and the deleterious effects of these drugs on long
we will utilize our initial testing data and the crystal structure information available for C. perfringens epsilon -toxin in concert with compu
Individuals most and least susceptible to the effects of sleep deprivation. The AMP also proved sensitive and specific in discriminating pati
es. The result of this effort will be to provide a basis for expanded use of MAD therapy by selecting patients most likely to benefit from this
n intrathoracic vacuum that draws venous blood back to the heart each time the patient takes a breath. This results in improved cardiac out
letely automated fashion. Phase I work will focus on fabricating a microfuidic platform upon which microliters of dried blood spot extr

s well as provide a very capable Internet connection. Service providers offer a variety of "on-demand" services. It is now possible to watch
st signs of AD. There is extensive literature that reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship
tion transfer between the homecare providers and the attending pulmonologists and respiratory therapists is likely to decrease the need fo
ople experience their first episode of low back pain in their early twenties, and it becomes more common as a person approaches his/her e
n many commercially available handheld computers and smartphones. The use of a standard wireless networking solution will allow a rese
will be able to transmit the data via a wireless network to a data collection PC. The system will implement a network protocol that will sup
tructure investments. This is of particular advantage to large government buildings and educational campuses. The proposed approach allo
pilepsy. Epilepsy refers to the tendency to have unprovoked seizures, and encompasses a number of different syndromes. It has a prevalenc
ncreased GP88 expression in breast cancer tissue correlates with clinical parameters of poor prognosis while normal and benign breast tiss
membrane platform over current histopathology tools such as immunohistochemistry (IHC). These include conservation of tissue (such as f
el of peptide targets and to demonstrate that they enable measurement of autoantibody profiles that can distinguish cancer from normal b

stem if the vector productivity were equivalent. We have constructed a cell line named c24 based on the human tumor line A549, which

search described in this proposal is to develop a product that will increase survival time or quality of life for patients diagnosed with malign
le laser will be identified and laser obtained. The optical and electronic modules of the breath analyzer will be designed. The instrument w
DI that is competitive with the HFA MDIs, with high drug delivery efficiency and dose reproducibility. We have demonstrated that asthma d
n and artemisinic acid in high yield. The second step, chemical conversion of these compounds to artemether, is likewise well-established. T
e mechanism of action has not been previously associated with pain. The identified drugs will be validated in animal models. Since the iden
ation with Stanford University, has developed a non-invasive sleep detection hardware/software system based on motion signals detected b
duct behavioral cognitive testing, and simultaneously monitor sleep and wake activity in mice at their homecages. Our Specific Aims are to
x, tissue-specific proteins, etc.). We believe that Affinergy peptide linkers can be pre-incubated with therapeutic cells to accomplish the fol
a significant amount of structural complexity. This complexity provides a larger "chemical space" from which a binding peptide can be foun
drawbacks of autograft, allograft, and xenograft. Affinergy's peptide linkers provide two improvements on existing bone grafts that could s
hemically crosslinking combinations of MSC binding sequences with Affinergy's polystyrene binding sequences. These IFBM's will then be t
is to prevent falls and thus reduce the morbidity and mortality associated with fall injuries. 2. Postural Perturbation - similar to ambulation
 etween the surgical fap and the underlying regenerative site. Nevertheless, an unnecessarily high failure rate exists in GTR procedures due
seful product for periodontal bone regeneration is another important objective. Phase I support for this project enabled the creation of a p
ations allow students to learn about the intricacies of interdependent complex systems by essentially becoming organs and engaging in a si
ements, the project will focus on developing and integrating a Particulate Matter sensor. The particulate matter sensing element is based o
ave identified several specific improvements to the InvTool program that will (a) improve general ease of use, (b) improve accessibility for v

utral antagonist to other antagonists under development showing that the AIKO neutral antagonist evokes limited adverse side effects; and
utcomes). Improve research management and monitoring in a Good Clinical Practice-compliant environment. The resulting solution will a
dable spacer. The materials used for this spacer chemically react in the presence of water generating non-toxic degradents which are either
hese objectives by taking advantage of Akonni's exclusively-licensed intellectual property portfolio acquired from Argonne National Laborat
s on the Akonni gel element array platform; integrate the sample preparation and RT-MME-PCR array functions into a plastic test cartridge;
. We will develop and test and refine core fuidic technology based on hydraulic/pneumatic and computer control with sensors to create an
hroughput of the CCD detector with the high sensitivity of the PMT. In addition, the detector array can measure fuorescent lifetimes of 2 n
by the placement of the photon detectors very close to the source of the fuorescent signal within the microfuidic channel. In Phase I, we
radiation resistance than current scintillators. Beyond the excellent scintillation properties of this new and advanced scintillator, it will be f
he goal of the proposed project is to explore a new detector for neutron imaging studies based on a bright Gadolinium (Gd) compound. Ad
(RMD) in collaboration with Dr. Raoul Kopelman from University of Michigan, will develop a near infrared (NIR) diffused optical tomograph
e illness and deaths from lead poisoning. This proposed effort will examine the feasibility of designing a very inexpensive, simple to operat
window applications. It is the aim of this proposal to combine the two already developed technologies so as to produce LSO in the form of

s in small animals. This new imaging technology has enormous potential in both medical and non-medical applications. The estimated mar
se imaging modalities in order to exploit their full potential. The goal of the proposed effort is to investigate a new high resolution detector
ndent PET and MRI scanners.
vide better insights into biological systems, and polymers and other ordered structures. For example, it will provide better understanding o
ble in Phase I but total recall comes with a price: we make lots of mistakes. The key innovation is that we keep score of how confident we a

ugation steps, and involve very expensive and complex instrumentation. In this grant application, we propose to develop new ELISA assays
availability of CBD is only about 6%. Therefore, the transdermal delivery route will be used in order to provide substantial plasma CBD level
ell as nonthrombogenicity. Prototype catheters coated with this technology will then be produced and tested against clinically relevant bact
ves that are biopsied. However, earlier studies in which ultrasound was evaluated largely as a primary screening tool reported a wide varian
ed research is to determine the efficacy targeting a- emitting radionuclides to the nucleus in vitro at the cellular level and in vivo in melanom
ication, Ac-227 will be separated from these sources and separation techniques yielding high quality Ra-223 will be demonstrated. Addition
owing objectives: 1. Design and prepare mono- and disaccharide substituted polymeric transducers; 2. Optimize binding density, multi-vale
e II with the aim of commercializing BS-LIVE-PRO. We will apply BS-LIVEPRO to autoimmune diseases in collaboration with Dr. Donald Bloch
of the ability to detect drug resistance mutations in subpopulations of HIV-1 down to the 5% level and iii) Sequence- based determination o
ation of the ability to scan the complete MCR region of the APC gene, ii) Ability to achieve high sensitivity (~1%) to detect chain truncating m
s an ELISA-based protein truncation test (ELISA-PTT) to detect chain-truncations. In contrast to conventional PTT, ELISA-PTT eliminates the
oncomirs," have been found in more than a half dozen different cancers and the number of oncomirs is growing rapidly. In this phase I appli
ill need to include molecular identification. It is our goal to develop a comprehensive assay system which 1) rapidly detects aberrant seque

rain-derived GPCRs. The results of this work will positively impact not only structural analysis of GPCRs, but will also be useful in other app
ons. In Phase III we plant to commercialize RHHP in conjunction with our partner, Steris Corporation. This research will demonstrate that h
is no adequate treatment. An effective treatment for gastroparesis can significantly benefit the quality of life for those who suffer from the
ave identified Ang 1170, an organic small molecule SF/HGF mimetic. Our studies indicate that Ang 1170 activates the SF/HGF/c-Met pathwa
ry data from regulatory safety studies suggest that these chemical class members are safe and well-tolerated. Using rational drug-design ba
HGF mimetic that could serve as important therapeutics in ameliorating lung dysfunction and reducing early graft failure following transplan
targets another receptor tyrosine kinase, Tie-2, involved in angiogenesis and in particular with sustaining tumor neovascularization. In vivo
Scleroderma and lung fibrosis. While HGF, IFN gamma or other cytokine administration holds therapeutic promise, there are several drawb
engine, Angion identified the small molecule Ang797, an active kinase inhibitor that competes with ATP for the ATP-binding site of Met. Ou
working hypothesis is that Refanalin acts as a neuroprotectant while promoting cell proliferation, axonal growth, and functional recovery i

normal tissue even in immunodeficient nude mice. We rapidly selected this bacteria by labeling them with GFP and imaging their ability to
ents to a rapidly-developing field of basic research. Infectious HCV for drug discovery.
enabled bioprocess platform for recombinant peptides and proteins can help meet production requirements, at all levels of production fro
gnostic sensitivity and specificity for detection of early AMD in a cross-sectional study of 200 patients (50% normal old adults; 50% having a
in D3 analogs. In the latter case, PG may have the added advantage of countering the irritation from breakdown of skin barrier function cau
udes formulation of 1,25(OH)2D3-3-BE in nanosomes, determination of the bioavailability and quantification of the drug in formulation, de
snoring is never benign in children. The public health implications of the proposed research are considerable. SRBDs are common, serious c
emonstrated that administration of our SK inhibitors reduces vascular leakiness in two animal models, including a VEGF-induced subcutane
or of this grant, Dr. Haval Shirwan, developed a novel form of FasL with potent apoptotic activity using ApoImmune's ProtEx(tm) technology
effective in preclinical models. However, the therapeutic efficacy of these vaccines has been limited in clinical trial settings. Although the re
or T regulatory cells that are implicated in tumor growth. A vaccine formulation consisting of ApoVax104 conjugated with the human papillo
l effects of shRNA-loaded constructs in human MM and in vivo work with a mouse xenograft model. In addition, we plan to expand our res
facets). This technology results in a higher number of accurately detected protein crystals, with a concomitant decrease in false positive h
n course - The outline will delineate course materials into broad categories or course modules 3.) Implement three prototype modules for t
will be implemented in C++ programming language. The utility of the graphic display will be measured using both a realistic patient simulat
opioids. 3. We will characterize differences in the drug-drug interaction in patients scheduled for elective surgery who chronically consume

at will provide significant benefits while maintaining low bleeding risk in established animal transplantation models.
hids and mosquitoes, and by APTIV scientists to laboratory classification of several Aedes and Culex species as well as lepidopteran pests in
of future ability to tie ecotoxicology to human health, a goal of the National Center for Toxicogenomics. Experiments by our research group
electrosurgery, the drug(s)-eluting stent has the potential of being superior to any single endobronchial intervention including a regular ste
ent for a cardiac catheterization procedure. This project will contribute to public health by improving the quality of understanding achie

tion will allow laboratories to conveniently maintain accurate inventory control and facilitate improved experiment planning. This workfow
nt field. We have developed MedScan, a fexible protein information extraction technology. We now propose to extend its scope into the m
ate that these human mAbs recognize an epitope on alginate that is defined by the highly charged carboxylic acid component of the uronic
udies show that a large enzyme with a molecular weight >100,000 Daltons, can be delivered to brain via transport across the BBB, following

earch at the Veterans Affairs Medical Center, Washington, D.C. At the end of Phase II, the full-performance, preproduction prototype of CFM
cause remains untreated. In addition the long-term effects of anti-angiogenic drugs are unclear. It can be assumed however that they migh

al technician. Therefore, we also propose to develop a new mouse holder as part of this work. The specific aims are therefore: 1. Develop a
erface, and alarm algorithm. In addition, optimization of the fiber-optic interface will be aided by experiments performed with a population
uman proteins, then show proof-of-principal for the sensitivity and reliability of the film sensor element. In the Phase II of this program, the
1: IV dose ranging to determine optimal dose of human MAPC; Aim 1.2: Optimal timing of delivery, post-HI injury; and Aim 1.3: Benefit of m
esia in mice and rats for 3 to 5 days following a single subcutaneous administration of the formulation. This long acting formulation will be

ed region of the DNA. Because the PCR primers are introduced in the probes, a single set of PCR primers can be used for a large number of
occlusion effect permitting pure tone and speech hearing tests to be conducted with a single transducer arrangement and facilitating autom
bacteria or fungi. They are typically very specific, potent and efficacious drugs, but their use can be associated with significant side effects
models of sensorineural hearing loss and complete the requisite laboratory work to apply for an Investigational New Drug Exemption from
release that has demonstrated promising results in vivo for other drugs, and that we believe is can achieve clinically useful sustained relea
necessary preclinical work to apply for an FDA Investigational New Drug Exemption. The team of investigators is expert in drug developmen
ever, the use of TGF-a peptantagonists for treating pulmonary fibrosis is limited by its poor solubility in aqueous solution at neutral pH. The
measuring plaque burden in AD patients. If 123 I-IMPY has suitable clinical properties as a biomarker for measuring amyloid plaques then P
nt we propose to conduct the first ever clinical trial of F-FP-DTBZ in T1D and T2D patients and rapidly test the hypothesis that F-FP-DTBZ is
el goat animal model which allows for functional and histomorphometric assays of axon regeneration efficacy though a large nerve gap and
bjective is to develop AK295 into a clinical drug for the prevention of CIPN. This Phase I STTR proposal describes research goals that are req
e predict will increase antitumor activity and ameliorate the reactogenicity of BCG. BCG strains expressing RD1, a pro- apoptosis factor, or b
nd proof-of-concept data confirming that BA0123 is increased in CSF following brain injury was obtained from preclinical studies. Subsequen
lpha and item-total correlations will be computed for each of the conventional psychometric instruments as well as for the new approach.
onance imaging, can document structural brain damage, assessment of infants' endogenously-generated (i.e., spontaneous) movement pa
human subjects in a validation trial against conventional measures. The accurate assessment of pain is an important goal; the first decade

owth into a bacterial culture. The proposed study consists of three major assignments: Task 1. Optimize F- spores as biological indicators

stage. Phase I of this fast-track STTR application proposes to build the initial prototype of the smart disk engine, to implement comparison
e CDCU to a no treatment control group. There are substantial public health implications from this project. Developing a suite of Internet a
bility via a pilot study with SMART Recovery members and evaluation by a panel of experts on SMART Recovery. Phase II goals are to comp
ons; 2) Estimate the construct validity of the final HSI-A by analyzing the similarities and differences in scale and subscale scores between t
multimedia program and its evaluation in Phase II. Major depression is a pervasive and debilitating disorder, for which the majority of indivi
n to evaluate knowledge gains in PCT-A, recall of PCT-A components, and self-efficacy in conducting the initial two sessions with adolescen
ys will accelerate drug discovery focused on RGS proteins and delineation of their roles in GPCR signal transduction. Over half of current dr
hase I, we will show feasibility for fabrication of a commercial fFCXHTS device. The static gradient chamber will be incorporated into an arr
nd to functionally validate it for robust high throughput tumorigenesis assays. Prototype devices will be fabricated from elastomeric polym
creatic a cell progenitors to treat type 1 diabetes. Lay Abstract: Human embryonic stem cells (HuES) have the potential to generate an unlim
per's in vivo non-invasive imaging system to quantify the real-time effects of Bexion's treatment agent on the size of these tumors before, d

ng Inc. is addressing this need by developing an innovative computer controlled and motorized system that enables safe and effective stren
g a pharmacokinetics study). Therefore, we propose to refine and expand the capabilities of a prototype movement-responsive cage that w

enzymes were used for the commercial production of six different drugs in clinical trials. In this Phase 1 SBIR proposal we plan to investigat
red near benign lesions (223 mV/mm) was only one-third the size of those near malignant lesions, making it very easy to distinguish betwe
l software. By using five positional degrees of freedom (DOF), the robotic placement device will have unprecedented fexibility in placing a
sign of a current scientific practices evaluation protocol in two test laboratories, integrating viewpoints from all members of the project tea
(due to thoracic location of tumor which increases the chance of lung collapse with a needle biopsy), the development of a non-invasive m
MDA amplifications with small quantities of input DNA can result in a loss of genome coverage. If we can successfully commercialize pWGA,
gurations that provide higher throughput and compatibility with robotic systems. The technology developed as a result of the proposed pr
(Bacteroides, Clostridium, Lactobacillus, Escherichia). These were selected as highest priority because we have received requests from mo
sence or absence of a suspected pneumothorax in over 40 patients at two metro-Detroit hospital emergency departments. While originally
gnaling pathways. In this regard, we have clearly demonstrated in several studies that following treatment with anti- selectins, the impaired
Verres disposable needle. Our hypothesis is that once HAF is injected in the peritoneal cavity, it distributes and adheres evenly to the walls,
nstruction. These algorithms will include but not be limited to the following: successful import of space-time datasets from environmental
d States. Instructional materials will be developed to promote the use of this relatively new methodology among health scientists. Phase I o
 death. The major innovation is the creation of methods for analyzing and modeling the residential histories of cases and controls to identi
and integrating various MEMS and ASIC chips into a unitized singular micro scale chip to perform a number of systems activities (i.e. powe
put genomic analyses in future patient care.
fused to carrier immunogens identified in the screen in Aim 1. (3) Produce polyclonal antibodies to several peptides produced by immunizi
opose to analyze FlaB, several groups of OspC, BBK32 and DbpA to define additional antigenic linear epitopes. We will then make synthetic
opus. After treatment, we will assess vaccine efficacy by analyzing B. burgdorferi infection prevalence of the host and of the tick vector. We
sive and will be widely assessable. The test will utilize FDA-cleared compounds that are known to be GFR markers. As a result, our propose
ubjects over long periods of time. These tools will aid our understanding of specific disease processes. In addition, these tools are necessar
und to an inert matrix, which should afford a toxicity profile comparable to chelated gadolinium. Phase I study will focus on toxicology, biod
esent in a relatively high level in human serum, the development of an assay to recognize soluble TL1A in the serum, either unbound or bo
tients, we propose to test whether the protein provides a survival advantage in an animal model of sepsis. Undoubtedly, the positive outco
peed and robust system design. The increased image acquisition speed opens the possibility for the first time for ophthalmic OCT imaging w
1. To evaluate the accuracy, threshold of detection and usability of a laboratory prototype instrument (alpha unit) and version 1.0 assay in
E. coli. (2) Use lsGG to replace a large 82 kb chromosomal segment of E. coli with up to 32 kb of synthetic DNA. (3) Use lsGG to replace a se
s azo bonds of our Black Hole QuencherTM dark quencher molecules to anilines leading to loss of quenching and thus to generation of fuo
of seizure. There are many good reasons to study how activity from individual neurons is organized into brain networks, and how the recru
for a high-quality acoustic inventory. We propose to use VT in combination with speech synthesis to convert the synthesis system's acousti
en, rectal swab, and stool samples. If we demonstrate that stool cards and rectal swabs are a reliable representation of the lumen and muco

n, allow us to test another potentially highly effective medium for health information delivery to Black Americans. Our long-term goal is to h
spiratory fow rates of 20-30 l/min. The alpha prototype will be robust, functional, manufacturable, and have patient friendly features. SUP
teresting background of commensal organisms or host nucleic acids. We plan to build on our promising prototype system for general bacte
mize suitable chemical protocols for covalent attachment of biomimetic layer(s) on outer sensor surface for improved biocompatibility and
ancer, autoimmune diseases, diabetes, and cardiovascular diseases. As both initiators and executioners of apoptosis, caspases serve as imp
o data collected from that well. We propose to optimize the first two steps in this process, namely, seal formation and entry into whole-cel
: 1) User interaction and interface design, 2) physical design and configuration, 3) software design and development, and 4) hardware desig
g-compatible tooling for TSA navigation in order to replace bulkier optical trackers that are typically used in computer-assisted joint replace
mma cysteine mutein for commercial development.
the site for the covalent modification of the protein using a thiol-reactive PEG. This technology allows for the creation of novel, fully active
he optical doubler to the system will allow for the deformable mirror to correct for low order (astigmatic) aberrations. This large stroke, com
he quantitative D-dimer 0.45 or a D-dimer 98% and specificity >50%. These highly feasibly specific aims will provide background data need
ly a coating which is capable of releasing metal ions when exposed to moisture. Antimicrobial silver ions are particularly useful for in vivo u
ctive molecules, called specifically (or selectively) targeted antimicrobial peptides (STAMPs) were successfully developed. The Phase- II stud

(LANL), developed Reagentless Pharmacoproteomic Measurement (RPM), a patented technology which uses micro-X-ray fuorescence to q
enium, etc.). Individuals with autism may have varying genes that biotransform and detoxify metals differently, leading to varying accumul
Horiba XGT 5000 XRF microscope, and a custom-built confocal XRF microscope, FPLC, and an Applied Biosystems Voyager-DE STR MALDI-TO
of protein dynamics and homeostasis. Thus this collaboration brings together a unique combination of strengths. In the proposed SBIR Ph
DJ-1 expression. (2) Identify inducers of DJ-1 expression by screening a proprietary library of ~50,000 compounds. (3) Select DJ-1 inducing co

develop a stand-alone unit capable of repeated point-of-care measurement, and ready for entry into clinical trials. The project work would

Aims are to: 1. Assess the human CPCs' differentiation into cardiac muscle in culture, using treatments that trigger the cardiac phenoty
structured into 3 specific aims: (1) the formulation and characterization of PLGA nanoparticles with the novel surface modification, (2) the i
ur commercial absolute cerebral oximeter will perform similarly for adult humans. The proposed studies will focus on transforming the exis
) who have attended a BASICS Workshop to evaluate the current video and identify its clinical and technical strengths and limitations; (2) to
ve deficits and correlate these changes with their pathological improvements in PSAPP mice. Furthermore, we also plan to infuse these mic
ges in blood glucose levels, and by immunohistochemical evaluation of the explanted implant site; and 3) Demonstration of human pancre
enable expanded utilization in areas such as in vitro study as well cell and tissue transplants.
ge therapy tool for treating prostate cancer and; (4) the utilization of this device may also be an effective nerve-sparing procedure. The Spe
e nerve-sparing agents and may also eventually be applied for urethral protection. The Specific Aims of the Phase 1 are: SA1 Determine th
ffinity technology we developed for phosphorylation profiling and will be identified by commonly practiced liquid chromatography-tandem

ractions that are described in PhosphoSite(r). PhosphoSite(r) and the Cancer Phosphoproteome Project Narrative The PhosphoSite(r) datab
man hepatocytes. The successful completion of the project will provide the pharmaceutical and biotechnology industry a better and more c
ach of cell- based HTS with pooled phage libraries displaying millions of peptide compounds, which far exceeds the complexity of small mo
enes responsible for the growth limiting actions of TGF-a in cancer cells. In Phase II, we will extend this program to include the developmen
sultants at University of Rochester and University of Utah, we will develop and maintain a FV shRNA database and algorithm for prediction
monstrated that a single infusion of allogeneic MPc protects against a subsequent challenge with an otherwise lethal dose of Aspergillus fu

etic particles coated with a chemical polymer, which seems to be highly effective for isolating and concentrating HIV-1, HBV and HCV from e
of ventricular CMs and 2) to validate the ability of this population of ventricular hESCCM as an in vitro model for cardiac safety. CDI wa
cations within the parameters allowed by this demanding commercial application. Some of the challenges include identifying the different
as biological detection tags. For instance, SERS nanotags are highly multiplexable based on excitation from a single laser wavelength, an im
ds for multilayering of crystals. In Phase II, TRS expects to develop a 2-D array transducer in conjunction with a medical industry partner.
ted annular array with broad bandwidth for use in interventional cardiology. This device would provide a three dimensional representation
nti-infective leads via the synthesis and evaluation of two prototype macrolide neoglycoside series. The 'type A' C6 prototype design is bas
ter in the cell based assay will therefore be the primary assays used to assess the potency and therapeutic index. The synthetic studies will
actor for further development of this technology, namely the design and optimization of the perfusate to maximize the yield and viability o
BC is a critical component of patient diagnosis and treatment. There have been no fundamental improvements in the technology used to d
ty and accuracy of CCi's proposed anti- EA assay. CCi also proposes to demonstrate the versatility of this assay by examining the anti-EA in a
analogs with improved anti-angiogenc activities and less side effects are desired. A collaborator of this project has synthesized a series of n
The market size for neovascularization, diabetic retinopathy, and macular degeneration treatments is estimated to be greater than $9 billio
s block the expression of retinal vascular permeability factors, VEGF and hypoxia induced factor-1a (HIF-1a), a major transcription factor up
al Path Platform) of the investigator organization, Chembio Diagnostic Systems Incorporated. Development of the test will be made possibl
ctuators that assure confined analysis. The recognition of the right target is achieved by fow-through hybridization and an enzymatic casca
ent ACCs, and to confirm ACC as their target, using enzymatic assays. Obesity is a common and prevalent nutritional disorder linked to sign
can be applied to the remediation of drinking water, water for medical use, such as dialysis, and groundwater contaminated by arsenic.
elop optimal test conditions for quantitation of these biomarkers in human cervical secretions. Premature delivery is a significant public he
the efficacy of the TEACH system, both pre- and post-exposure, form the evaluative core. Data from these empirical feasibility assessment p
rogression as well as the evaluation of prophylactic treatments and therapeutic manipulations that sustain and support immune mechanism
ridge, and pattern recognition software for analysis. Highly parallel detection of the targeted protein biomarkers is based on an advanced la
will combine MHC-peptide arrays in a self-contained sample cartridge with a highly parallel luminescent detection system that is capable o

ptoms. Modules will include motor, physiological, speech, and olfaction. The MPPS will aid in PD screening and diagnosis, defining diagnosti
Studies performed in small animals including rodents cannot be directly extrapolated to human tissue. Preliminary results from this and ot
organized, interactive resource unlike any other that currently exists for dementia caregivers. In Phase I we conducted a needs analysis wit
 Emergency Medicine Residents was "where are the next 5 modules?" Given the physicians' requests for additional education, the positive
alogs. These studies, with some additional investment, will complete the preclinical package necessary to file an IND application with the Fo
d with the cerebral microvascular amyloid deposition. Furthermore, Tg-SwDI mice show marked deficits in behavioral performance. In ligh
of COG112 using clinical outcome measures, histological outcome measures and measures of a panel of representative infammatory media
significant anti-infammatory effects within the brain. Cognosci Inc. has investigated the anti-infammatory effects of ApoE for several year
rial species will be evaluated to determine the dose of COG133 required to reduce mortality. The optimized dose of COG133 will be used in
opose to examine our lead compound COG112 as remyelination-promoting agent in the following aspects: 1) Specific Aim 1: We will verify t
compounds in myelin oligodendrocyte glycoprotein (MOG)- and proteolipid protein (PLP)-induced EAE models mimicking the PP-MS and R
physical characteristics of uncured bone adhesive. In brief, the physical characteristics of the adhesive (such as viscosity, cure time and exot
cteristics of the tissue adhesive for spray delivery. In brief, the physical characteristics of the adhesive (such as viscosity, Young's modulus, c
o mouse skin; 2) elicit the same concentration of infuenza-specific antibodies using lower doses of vaccine in mice; 3) enable lower doses
g study will be conducted. A novel task for the identification of words within carrier sentences will also be developed in Phase I and will be

high fux composite membrane modules. Then we would focus our demonstration on IPA-water systems operating in pervaporation (PV) m

structure-activity relationship of puerarin derivatives with modifications on the different rings, leading ultimately to the synthesis of potent

e instrument's outputs to the auxiliary input(s) of the patient's CI(s). When used for direct-connect testing, the computerized instrument wi
uum pumps that are normally used in routinely employed mass spectrometers where the sample of air to be mass analyzed is introduced c
, many individuals with chronic pain find it difficult to obtain treatment due to rising health care costs, increasing demand, and a reduction
roach in Aim (1) and conduct preliminary testing of the resulting software. (3) Conduct preliminary studies using the fast mPBE solver to as
reagent. The specific aim for Phase II is to optimize solder processing, laser techniques and surgical outcome in survivor animal surgical m

use, and able to successfully transport a dentate bone segment across a 2 cm bony gap in a live goat model. The objective of Phase I of this

ems, create algorithms for a fully operational LLFDI-CAT system, and implement a dissemination plan. The LLFDI-CAT will fill a critical void fo
ate design drawings, and then evaluate full-scale models of the two designs. Bench models of the two stabilizer designs will be prepared in
d patient trust by detecting selection bias; 4) Present the results to patients in ways that are more meaningful and relevant to experiences t
lator; 2) to develop NuStep-specific adaptive stimulation control algorithms; 3) to validate controller design through simulation studies; and

g light sources and detectors, (2) to design and develop algorithms for sensor operation and data analysis, utilizing phenomenological mod

herapeutic (non-antibody) protein; (2) extend Cell Xpress into labor-intensive downstream operations; (3) apply Cell Xpress to bioprocess op

nologies is expected to provide a novel means of developing functional tissue engineered constructs that can improve the success of cartila
These tumor cells cannot be lysed by specific T lymphocytes unless a specific treatment results in enhanced T cell recognition of the tumo
of a new CYP gene with selectivity to the central and peripheral nervous system, coupled with the observation that EETs, products of CYP4
many clinical problems need a more robust response that includes remodeling and expansion of larger vessels, a process that requires a co
ncapsulating the protein in a reverse micelle system and dissolving the entire assembly in a low viscosity fuid such as liquid ethane. Protei
e a facilitator's guide, student workbook, and video/DVD. The unique combination of peer mentors, workbook and facilitator activities, and
ovide treatment and training materials for professionals that are easy to use and integrate into existing community residential and outpatie
ment for this disorder. TREAT will be designed to increase awareness and knowledge about TTM among cosmetologists, and to help them e
hancing their engagement skills, thereby increasing access and quality of care for these families. During Phase I, the research team will acco

vational engagement techniques to increase adolescent motivation for treatment and adoption of healthy behaviors; and (3) counselor, pa
 nbiasness, consistency and efficiency. We are interested in the development of more robust methods to achieve these goals for continuou

nd lack of access to peers with CF due to risk of infection leave many teens with CF feeling isolated and alone. Due to parent over-protection
order educational video series for family members, including four 30-minute video programs and a printed viewer guidebook; 2) Design an
tive CD-ROM. In Phase II of the project period, formative research will be conducted, including a needs assessment with students, teachers
Phase 1 clinical trial. Prior to the latter, DEKK-TEC proposes screening the analogs in a wide spectrum of tumor models to insure the best c

guage and culture. OUTCOMES: Effective but inexpensive method of translating the best of dementia care research in the management of s
tion (such as elevation, land use, lakes and rivers), demographic information (such as natural population growth, migration, education and
lest and least invasive surgery possible. The commercial potential will expand as new bioengineered materials, currently under developme
s of fetal alcohol exposure. Greek organizations consistently show much higher rates of alcohol use and abuse than other student populati
vention among oral health providers. In Phase I, we will develop an interactive theory-based prototype of the web-delivered training progr
es will be "tuned" in order to optimize practical aspects of their use in humans. Although we are directing this study specifically against P. f
t the product to a broader range of potential users will also be developed. Having more detailed information about a locality's older popula
e of the usefulness of the DRW HBsAg rapid test for pre- and post-donation screening in resource-limited settings, additional evaluations w
arker discovery in patient plasma samples have yet to be demonstrated with an optimization study. Such a study is proposed here, in which
cluding disease diagnosis, the monitoring of disease progression, drug discovery and development and the monitoring of drug efficacy in p
become a robust model for patient-centric disease management. Poor adherence to medications costs our nation $100 billion each year. A
o be applied to run off a mobile phone as a step towards more continuous mood monitoring. The project is significant as it can provide a n
s will focus on developing a cell-based technology to measure interaction of the subunits of cAMP dependent protein kinase (PKA), and the
ProLink. Because the system complements only weakly, when EA and ProLink are genetically fused to two proteins that interact, the intera
LexA operator sites to which the targeting tether can bind. 2: Evaluate the efficiency in cultured liver cells (HuH7 and HepG2) of a LTT targe
ed to be addressed; (i) What is the effectiveness of SB-mediated FANC gene insertion in the treatment of an animal model of FA? (ii) For the

orkplace. Since each worker downloads his noise exposure data on a daily basis, a large amount of data is generated across a typical indust
dentify and prioritize a small set of molecular targets predicted to be critical for macrofilarial survival. In addition, as a prelude to Phase II r
sizes development of a novel liquid-lens element and assembly of a liquid-lens array microscope prototype. The evaluation of the prototyp
ation we propose development of a new software tool, ThermoBLAST, to fill this critical technology gap. This objective will be accomplishe
etry system. E. Obtain outside feedback on the dosimeter's utility from the potential medical community. We envision the potential comm
MRS (1H, P, and C) may prove 31 13 useful in evaluating metabolic changes that are important indicators of leukemia progress and respons
each of the remaining three most important and technically demanding specifications simultaneously: rf field strength, spectral resolution

performance of the prototype device. In Phase II we will customize the packaging of the CMOS readout chip with a thin motherboard and
lead to: potentially significantly reduced x-ray dose to the patient, compositional analysis of tissue through spectroscopic x-ray imaging, an

-BFV responses to these physiological maneuvers, and to compare them to standard autoregulation indices obtained in populations of 118
mpounds to be used in the continual battle against antibiotic-resistant bacteria. More broadly, a method will be developed to access more c
technical solutions have not explored the possibility of manipulating this catalytic reaction. Therefore, this proposal tries to investigate a no
raphy, total-body electrical conductivity, total body potassium, and skinfold thickness measurements, have been used sporadically and with
avage sites for proteases from the most common wound pathogens. The resulting assay will detect the total number of pathogens but not

1; (2) Characterize and optimize the allosteric DNAzymes for toxin-sensing properties; and (3) Engineer fuorimetric or colorimetric mycoto
atory proteases from a class of "Protector Peptides" characterized by ECI. When applied to gingival tissue, possibly in combination with an a
properties of SLPI. In this STTR project, Edenspace Systems Corporation proposes to generate a new, low cost method of producing biologic
ggregation osmolytes and we have shown that the latter can enhance the efficiency of the system by partially stabilizing denatured protein
program, (b) student knowledge of the content and skills, (c) student use of the content and skills, (d) social validity of the program, and (e)
d allow a 3 billion base mammalian genome to be sequenced in under an hour, a 1000 times improvement over current systems. Such rapid
rane configuration comprised of a nanometer-scale pore (10 nm to 75 nm radius) in a millimeter-scale glass surface covered by a lipid bilay
shelf life, and affordability for parents and teachers to incorporate as teaching resources. A new advisory board with established expertise
ed into the system. The compact system would be fully automated and incorporate a spectral library with chemometric analysis. Identificati
d is capable of single molecule sensitivity (if desired). The core concepts of this technology have already been developed and demonstrated

was also compared with the current MRI standard, Delayed Enhancement (DE), in the same dogs and MRI sessions, to ensure comparison a
hool environments. Health benefits include capability for caregivers to access behaviors in a real school environment that should lead to im
ed of species that have never been grown in culture. eMetagen accesses biochemistry from the uncultured majority of soil bacteria to prod

effectively implement interactive / experiential service delivery, which is one of the most frequently validated contributors to affect preven
eliorate this crucial capacity bottle neck by developing a web-based tool through which states, counties, and local communities can realisti
heir worlds, and thus increase their social interactions. Breakdown of communication between partners in an AAC device-mediated comm
is to design, fabricate and evaluate a single- channel alpha version of the optical assay device that will provide point measurements, and c
cclusion but minimize the risk for clogging catheters, and (iv) no cytotoxicity. Sufficient clinical grade materials will be produced for future i
es and composition will be further optimized and the non-cytotoxicity will be validated. Sufficient clinical grade materials will be produced
gical cells both at high resolution and in their hydrated state. Currently available microscopes satisfy one of these requirements but not bo

l develop specific assays that can be adapted for implementation in the microfuidics environment for detection of target biological and ch
w prototype technology will be benchmarked against standard analytical laboratory methods and other available field tests, such as colorim

imarily on performance of these tasks, but placing them in a more environmentally realistic context. In Phase I we will develop and evaluat
erived products, alternative therapies are needed, but there is no reliable experimental system in which to develop and test them. The long

FT) devices include spirometry, forced oscillation (FO, e.g. IOS), and interrupter (Rint). These either require patients to forcefully exhale (spir
validate if these rbES cells can contribute to germ line cells after blastocyst injection and we will work to produce gene targeted transgenic
strated that inhibition of PK is more effective than depletion of FXII for inhibiting thrombin generation and coagulation by the intrinsic path
he multiplexing capacity of the assay and improving the efficiency and throughput of the image analysis system, while Aims 2 and 3 are foc
non-viral carrier to deliver the IL-12 gene as a treatment for malignant brain tumors and to combine this gene delivery with both locally ad
abbit model (1) increased tear fow, (2) produced tears of normal composition and (3) did not irritate ocular tissues. In addition, application
cl-x and CD44 from cultures of human cell lines and human serum samples. These aims in Phase I will allow for the utilization of a new tech
assay will be developed in-house to circumvent reagent license fees built in to pricing, and 2) use of a combination of public domain proced
ne against the standard bacilli Calmette-Gu rin (BCG) vaccine and as a boost in HLA transgenic mice pre-vaccinated with BCG. Successful com
hose epitopes using point amino acid changes as guided by EpiVax' validated immunoinformatics tools and techniques and (3) to demonstr
eened as drug candidates, can be used to monitor the performance of preparative chiral separation processes, or can be used as a chiral se
ing novel breath handling techniques that gate breath collection to end-tidal carbon dioxide concentrations, we show that ethanol appears
s of candidate "taggants" and their metabolites. Our Specific Aims are: Specific Aim 1: Identify 6-8 chemically diverse taggant candidates fr
ur long term goal is to develop commercially-feasible reagents that can be used to detect the in vivo formation of vulnerable atherosclerotic
m will focus on expanding the number kinases for use with the assays and developing the multiplexed format for high content screening.
mately, we envision a clinical system (device and method) for autologous fat transplantation that will produce more effective, more predicta

detectable in the serum of cancer patients but not in the sera of obese subjects. This tumor selective phospho-FAS would form the basis fo
ve genetic and biochemical research, providing a solid foundation upon which to build the fundamentals for the emerging field of predictiv
pplication of genetic and biochemical data for the improvement of a production process. The ability to identify important genes, enzymes,
measurements of UCBf. The second aim will include the enzymatic synthesis of conjugated bilirubin for interference testing and UCBf mea
ng in diabetic C57BL/KsJ-m+/+Leptdb (db+/db+) mice, we believe that our lead compound, ACT1 peptide will have beneficial effects in the t
the target was DNA. The Phase 1 milestone will be passed if similar success can be obtained with RNA as a target. Potential commercial ap
one with individual tests. AIR is capable of sensitive and simultaneous protein detection with a device that is currently the size of a laptop

els. (3) Sehda will then build the speech translation system on its S-MINDS platform. (4) Sehda will monitor the system's performance as n
y demonstrated, these capabilities will make it possible to test a vastly expanded number of variables that potentially affect tissue growth a
by automated protocol will be developed. 4) Demonstration of a mixed peptide/carbohydrate microarray. Fluorous-tagged peptides and mo
highly efficient, and parallel process. Phase 2 Application: 1 R43 GM075509-01 Principle Investigator: Khine, Michlle High Throughput Intrac
tive and proven sequence of assessment and prevention activities. Advanced online features of the assessment instruments and practice re
be constructed to record and document all parameters on a PC. In this Phase I feasibility study we will construct a working prototype of the
1 infection as a result of RHGP. We will identify and isolate corresponding host genes in resistant cells. The initial validation of these target g
he size of the preamplifiers to be integrated in each coil. There is no existing commercial preamplifier small enough for the large numbers
e is no known diagnostic available to define risk in a patient who is considered for androgen therapy. As such, this Phase I application outlin
een issued on these compounds, with the Principal Investigator (E. Richelson) and Consultant (P. Carlier) of this grant application among th
conceptual design phase prior to implementation.

fexible system for reliable communication.

results. The approach will also permit significant time for testing, optimizations and enhancements during Phase II.
e and allow for future anticipated GPS Modernization improvements, especially the evolution of military P(Y) capable devices to support M
rborne and/or orbiting platforms.

s from pavement unevenness, truck vibration, test not at exact point, and so on. In Phase-II, we will build and deliver 3 prototypes: (1) use

tem dynamics model will also be produced. This model will successfully demonstrate the shock effects of braking on the eddy brake as we

with this hardware. Under Option 1, we would adapt the PLADAR hardware and software for the Firescout platform. Under Option 2, we

ring Phase I.
g of analysis models and design geometry and supports data interoperability among different analyses. The framework facilitates rapid dev
ve medical shipments in transit; 2. report temperature, humidity, vibration and/or shock; 3. be compact in size; 4. be low cost and disposab

, and any of the Discovery or lunar missions that entail geologic evaluations. While a purely commercial terrestrial application is not envisio
steps that will significantly reduce nitrogen and phosphorus and will ultimately be used to support greenhouse activities.

cals will be examined and compared to the signatures of the individual components. These experiments will help us gauge the difficulty of
gy has the potential to dramatically improve the digestibility of cellulosic feedstocks, thereby enabling commercial-scale production and us

as environment. We were able to achieve a 60% reduction In capital cost of the TMC element via significant enhancement of the membran
the three chemicals will be examined and compared to the signatures of the individual components. These experiments will help us gauge

e. This technology has the potential to dramatically improve the digestibility of cellulosic feedstocks, thereby enabling commercial-scale pro

as environment. We were able to achieve a 60% reduction In capital cost of the TMC element via significant enhancement of the membran

nd transitional states and the potential for short event horizons.

ation thickness. Finally extrusion is a much simpler process than tape construction and may reduce harness cost by 50%.

h situational awareness sensor technology.

se. Additionally, design and analysis will be combined with the demonstration results to show traceability to the objective system design t
 network of near-surface greenhouse gas measurements to future satellite measurements. When used in climate models, these measurem
nitor deployed at these stations would provide high accuracy as well as high precision information at a data rate required for fux measurem

Software will provide Teamcenter requirements management, portfolio management, and maintenance execution software and services;
eyser® Denitrification Filter employing PHAs as a simple, low-cost alternative to the relatively complex existing treatment methods. The fina
ottling, and drinking water supplies, where this technology should assist in removing organic contaminants (e.g., endocrine disruptors), dis

oved survival of hybrid catfish embryos produced early in the season would represent a major step forward in hybrid catfish production and
worldwide.

should position it for distribution and marketing globally to eliminate iron deficiency.
infection model system and Dr Stephen Newman, Aqua-in Tech Inc has agreed to assist in marketing efforts and additional site identificatio

generate rapid market share growth due to improved production for the customer and compatibility with eradication programs.

near-source volatiles collection by sorbent tube and in-laboratory whole-air sample reconstitution for odor assessment.
osed network.
s override and an easily configured XML-based policy model which is stored in a backend database.

ered at the end of Phase I.

et of probabilities of the suspected material belonging to certain kinds of known chemical agents or hazardous materials.
vironmentally contained government facility.

ane replacement valve, and completing the necessary requirements to support a submission for clinical trials. We will be also be evaluating

l will combine the technical expertise of lung imaging by New Mexico Resonance with the permanent magnet technology being used by AB
esser, but no less important extent, patients and their families. In Phase 1, AEI demonstrated the feasibility of the effort by identifying salien

re are a wide variety rigid backrests commercially available; however, most are heavy, unappealing, and apt to fail under active use. Curren
 techniques based on other representations of chemical structures. Finally, a system that integrates chemical compound databases with bio
es from the HRS/SSA link and test their usefulness in statistical modeling; (3) perform studies of the statistical disclosure risk associated with
ons. The Phase One effort has the following objectives: i) Develop and optimize the electrostrictive array fabrication processing steps ii) Dev
ould counter retinal cell death under stress conditions that are specific for photoreceptor cells and/or RPE cells. Continuous light exposure
s proprietary retinal culture screening system, as a next-generation in vitro system for ranking the relative (photo)toxicity of environmental

tiality requirements of Census and CMS; (2) identify alternative methodologies for linking information about beneficiaries across Medicare a
f MedRIC; (2) develop an approach for linking information about beneficiaries across the different health administrative data sources main
iaturized microwave radiation energy for quick and convenient coupling carbohydrates on the dendron-modified nanoparticles, and demon
Glycomics study the interactions of carbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles

mproves the ratio of grip force achieved to the input cable tension (called the forward force ratio, FFR). ADA's prototype achieved a maximu
velopment for cocaine addiction. We anticipate that at the conclusion of these efforts we will identify 1 or 2 lead compounds and validate t
us effects of these drugs on long term islet cell function. The deterioration of graft function with time from islet exhaustion due to the tran
on -toxin in concert with computational chemistry to design additional beta-CD derivatives with enhanced affinity to the epsilon -toxin por
and specific in discriminating patients with the highly prevalent, under-diagnosed Obstructive Sleep Apnea (OSA) from healthy subjects. Th
s most likely to benefit from this treatment and providing measures to maximize the benefit to those selected. Dentists and dental sleep sp
s results in improved cardiac output and an increase in systolic and diastolic blood pressures. The specific aims of this research include 1) d
croliters of dried blood spot extracts, reference standards, and reagent droplets will be dispensed, transported, mixed, assayed, and dispos

ices. It is now possible to watch television programs and movies on your cell phone. What does this mean for chronic care? Self manageme
EG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. The use of E
is likely to decrease the need for hospitalization and provide a dramatically increased level of comfort for care providers in the home. Tech
as a person approaches his/her early sixties.
working solution will allow a researcher to invest in a set of sensors that will be compatible with new portable computing and cell phone de
a network protocol that will support up to 16 independent wireless EMG sensors. In phase I, AME has completely specified the IC requirem
uses. The proposed approach allows a cost effective solution to way-finding within these buildings.
nt syndromes. It has a prevalence of 0.5 to one percent. This translates to approximately two million persons in the United States. Furtherm
ile normal and benign breast tissue are negative, 6) patients with poor prognosis have elevated GP88 serum levels. These results highlight G
conservation of tissue (such as for core needle biopsies) and the ability to simultaneously profile multiple signaling proteins in both norma
distinguish cancer from normal blood samples with unprecedented sensitivity and specificity. Microarrays of the purified peptides will be u

human tumor line A549, which is as productive as 293 cells, is stable, is free of mycoplasma and carries 1-2 copies of an E1 expression pla

patients diagnosed with malignant gliomas. The patient population with unresectable malignant gliomas was chosen since these patien
l be designed. The instrument will be constructed and packaged for use at a medical clinic. The instrument will be deployed in clinical resea
ave demonstrated that asthma drugs can be effectively formulated in our compact and reliable inhalers. In our just-completed phase II SBIR
her, is likewise well-established. The third step, supercritical fuid extraction of the artemether product, has not been reported before, but i
in animal models. Since the identified therapeutic by definition is an IND, successful demonstration of efficacy in animals will lead directly
sed on motion signals detected by a piezoelectric film that lines the mouse cage foor under a thin layer of normal bedding. We now propo
ecages. Our Specific Aims are to: 1. Design and engineer a series of integrated circuit and microcontroller based wireless modular devices (
peutic cells to accomplish the following goals: 1) inducing limited clustering of therapeutic cells to generate aggregates that are too large fo
h a binding peptide can be found; making the success of phage display panning more likely within a short time frame. In aim 1, we will syn
existing bone grafts that could significantly improve clinical outcomes by stimulating bone healing. First, we expect that coating bone graft
nces. These IFBM's will then be tested for their ability to bind and retain MSC's from suspensions of MSC's, suspensions of mixed cell popu
turbation - similar to ambulation assessment the device will characterize an individual's baseline and be able to determine any significant p
ate exists in GTR procedures due to failure of the faps to heal with primary closure over the membranes and regenerative site, typically lea
oject enabled the creation of a prototype Perlecan expression construct for delivery of sequences encoding domain 1 (D1) of the core prot
ming organs and engaging in a simulation-aided discourse with other students and teachers. In the long term, Collective Simulations would
atter sensing element is based on the research being done at Washington University and measures the mass distribution of particles by size
se, (b) improve accessibility for visually impaired users, and (c) simplify the speech recording process, especially for young users and users

limited adverse side effects; and (iii) determining the maximum tolerated doses (acute and sub-chronic) of the AIKO neutral antagonist as a
ent. The resulting solution will advance the capabilities of the clinical and translational research enterprise and empower collaborative rese
oxic degradents which are either metabolized or excreted from the human body by a variety of mechanisms. These spacer units will be end
d from Argonne National Laboratory; proprietary antibodies, sample preparation reagents and know-how from Quidel Corporation; protein
tions into a plastic test cartridge; and test and evaluate the integrated prototype on an extensive panel of infuenza in neat and amended na
control with sensors to create an accurate system for sterile applications. A novel fuid sensor will be employed feedback control. The desig
asure fuorescent lifetimes of 2 nanoseconds, which cannot be done with CCD arrays and has better near infrared sensitivity than the PMT.
rofuidic channel. In Phase I, we will modify an existing microfuidic sensor to develop a test platform to demonstrate the integration of the
advanced scintillator, it will be fabricated in a microcolumnar form, which will provide very high spatial resolution. When combined with a
Gadolinium (Gd) compound. Advantage of Gd-based detectors is that this element has the highest cross-section for absorption of thermal
(NIR) diffused optical tomography (DOT) instrument for breast cancer detection using peptide based luminescent contrast agent. The propo
ry inexpensive, simple to operate, hand-held instrument, based on a revolutionary detector technology. The proposed instrument will be u
as to produce LSO in the form of a fully transparent optical ceramic, which displays scintillation performance comparable to that of a single

applications. The estimated market size for high resolution, reduced afterglow scintillator, high temporal and spatial resolution detector, an
e a new high resolution detector for nuclear medicine.

provide better understanding of disease progression, improved insights into viral structures through neutron diffraction studies. The propo
eep score of how confident we are of any given fact which gives us an important point of leverage in sifting good from bad facts. Our Phase

ose to develop new ELISA assays for determination of anti-D antibody that will be free from the limitations of the conventional agglutinatio
ide substantial plasma CBD levels with the added convenience of controlled release delivery. This proposal will test the overall hypothesis t
ed against clinically relevant bacteria including methicillin-resistant strains of Staphylococcus aureus and Staphylococcus epidermidis. The p
ening tool reported a wide variance in Positive Predictive Value (PPV) and an unsettling range of False Negative (FN) rate from 0.3-30%. Des
lular level and in vivo in melanoma animal models. The specific objectives of this research are: 1) optimize the radiolabeling efficiency and
3 will be demonstrated. Additional sources of Ac-227 will be identified and candidate reactors for Ac-227 irradiations required for the prod
mize binding density, multi-valency and mitigate nonspecific binding; 3. Implement binding assays for concanavalin A (ConA) and jacalin as
aboration with Dr. Donald Bloch at the Massachusetts General Hospital, a leading expert on autoantigen discovery and primary biliary cirrh
equence- based determination of drug-resistance mutations. In Phase II, a comprehensive HIV-1 genotyping drug resistance test based on
~1%) to detect chain truncating mutations, iii) Ability to detect mutations using DNA isolated from the stool of CRC patients. Significant imp
al PTT, ELISA-PTT eliminates the need for electrophoresis and radioactivity. A second and complementary approach, based on mass spectro
wing rapidly. In this phase I application, we will demonstrate the feasibility for an integrated technology for the isolation and quantification
1) rapidly detects aberrant sequences for resolving ambiguous diagnosis of AML, non-BCR/ABL CML and MPDs, and 2) is predictive of thera

ut will also be useful in other applications that benefit from abundant quantities of pure and properly-folded GPCRs, including drug screenin
esearch will demonstrate that hospital workers and others can be encouraged to wash and sanitize their hands by means of automated vo
ife for those who suffer from the disease.
tivates the SF/HGF/c-Met pathway and exerts organoprotective effects. Importantly, in a rodent model of ALF, Ang 1170 reduces mortality, a
ed. Using rational drug-design based chemical substitutions, we have now constructed structural libraries around these small molecules. Th
y graft failure following transplantation. The objective of our study is to extend the lung preservation time up to 12-18 hr for lung transplan
umor neovascularization. In vivo ANG 797 attenuates tumor growth and improves survival in orthotopic models of human glioma. Recent d
romise, there are several drawbacks associated with gene therapy, recombinant proteins, or peptide therapy because of instability in soluti
the ATP-binding site of Met. Our results indicate that Ang797 significantly and selectively inhibits Met activation and inhibits downstream
rowth, and functional recovery in the setting of SCI. As delineated in our Progress Report, administration of this small molecule mimetic of

h GFP and imaging their ability to target tumor labeled with RFP. This remarkable selectivity apparently refects the imposed nutritional req

nts, at all levels of production from research quantities to kilograms, in the biopharmaceutical, vaccine, biodefense, and biomedical researc
normal old adults; 50% having a range of early to intermediate AMD). Our goal is sensitivity and specificity = 90% with a test duration = 10
down of skin barrier function caused by vitamin D3 analogs. The Phase I specific aims are: (i) development of a suitable PG treatment form
on of the drug in formulation, determination of the stability of this compound neat and in its nanosomal preparation in serum and liver hom
le. SRBDs are common, serious conditions that are under-diagnosed and, therefore, under-treated. The Apneos SleepCorder has the poten
uding a VEGF-induced subcutaneous model in nude mice and a 3-month diabetic retinopathy model in STZ-treated rats. No toxicity to the a
Immune's ProtEx(tm) technology. ProtEx(tm) involves the generation of chimeric immunological ligands with a modified form of core strep
cal trial settings. Although the reasons for their clinical inefficacy remain unknown, the lack of a strong adjuvant effect, ineffective delivery
njugated with the human papillomavirus (HPV)-16 viral oncoprotein E7 will be generated and tested for its efficacy to induce an immune re
dition, we plan to expand our research to other shRNA constructs that block other signaling pathways. Since a universal obstacle to all siRN
tant decrease in false positive hits. Specific Aim I: A pre-production automated polarization microscope, the Crystal Finder(tm) microscopic
nt three prototype modules for the course - The prototype course modules (The Continuum of Sedation, Drug Pharmacology, and Airway M
ng both a realistic patient simulator and a clinical ICU study. Thirty critical care clinicians will be called into a simulated ICU to assess the stat
urgery who chronically consume opioids, and update the PkPd Display with these results 4. We will implement optimization techniques so t

n models.
as well as lepidopteran pests in agriculture. NSF have recently funded design and development of second generation instrumentation that
periments by our research group and others have shown that microarrays can be used to detect changes in gene expression caused by exp
tervention including a regular stent. AraVasc plans to address the need for a superior stent by developing a drug or combination drugs eluti
e quality of understanding achieved during informed consent. This may improved patients medical decision- making, decrease medical liti

eriment planning. This workfow-based system will increase the efficiency and reduce the error rate of genomic research by ensuring that t
se to extend its scope into the metabolic, toxicological, and clinical areas. We propose to build a prototype of a knowledge base supporting
ic acid component of the uronic acid monomers that make up alginate, and represent a broadly reactive epitope that may be an effective t
nsport across the BBB, following attachment to a BBB receptor-specific Trojan horse. The present work will produce a novel fusion gene en

preproduction prototype of CFM will be developed, a clinical trial of the effect of CFM on training and ongoing education will be performe
assumed however that they might lead to the exacerbation of vessel loss, the precipitating event for neovascularization. Therapeutic stem c

aims are therefore: 1. Develop a mouse holder to restrain the animal and expose the fank for biopsy and/or injection. Integrate an existing
nts performed with a population of human subjects. Through these studies, the feasibility of the proposed nocturnal alarm will be evaluate
the Phase II of this program, the detection films will be incorporated into a reader device and the reproducibility and accuracy of detection
I injury; and Aim 1.3: Benefit of multiple IV dose administrations. Aim 2: Demonstrate stable and long-term therapeutic behavioral and hist
s long acting formulation will be a solution of buprenorphine base in an appropriate pharmaceutically acceptable, injectable, water-miscibl

an be used for a large number of targeted sequences. Other researchers have shown that a similar process called MARA, which also can use
 rangement and facilitating automated test methods; 2) increases ambient noise exclusion, eliminating (in many environments) the need for
ated with significant side effects, and for some compounds the side effects are severe enough to impede clinical use. Moreover, although i
tional New Drug Exemption from the FDA. Many forms of deafness could be treated with drugs; however, most drugs do not penetrate suffi
e clinically useful sustained release for the calcineurin inhibitors. The specific aims of this proposal are: to formulate sustained release susp
ors is expert in drug development, polymer chemistry, neuropharmacology, pharmacokinetics and clinical neurology. We have experience in
eous solution at neutral pH. The goal of this proposal is to develop novel TGF-a peptantagonist derivatives with increased solubility, long pla
easuring amyloid plaques then Phase II will test the characteristics of the biomarker in longitudinal studies of AD and mild cognitive impairm
the hypothesis that F-FP-DTBZ is a useful biomarker for PET imaging of BCM. 18 Successful development of a biomarker for beta cell mass (
acy though a large nerve gap and long regeneration distance to the muscle target tissue. Our proposed functional assay for motor axon reg
ribes research goals that are required on the path to approval of an IND applcation for testing AK295 in people. Our preliminary data show
RD1, a pro- apoptosis factor, or both will be validated genotypically and phenotypically. This project will be milestone-driven and at the con
om preclinical studies. Subsequently, a second complementary neuro-biomarker (BA0252) was discovered and a specific ELISA assay for its s
as well as for the new approach. Success for internal-consistency reliability will be defined by demonstrating values for Cronbach's alpha =
.e., spontaneous) movement patterns, known as "general movements" (GMs), provides a method by which to assess CNS function. In the p
important goal; the first decade of the new millennium has been declared the "decade of pain control and research". As further support, t

- spores as biological indicators for sterility assurance after steam sterilization. A biological indicator prototype will be produced, s

ngine, to implement comparison logic mirroring the stages of the widely used BLAST pipeline, to construct a transparent software front end
Developing a suite of Internet and Windows based programs increases the ability of universities to use these programs and the likelihood
overy. Phase II goals are to complete the development of a program, pilot test it and conduct a randomized clinical trial with a 12 month fol
e and subscale scores between the student sample and the clinically defined contrast group; 3) Assess the HSI-A for criterion-related validi
r, for which the majority of individuals receive no or inadequate treatment, despite the fact that efficacious treatments exist. Increasing the
tial two sessions with adolescents diagnosed with panic disorder. In the event of a successful Phase I test of feasibility, we will substantially
sduction. Over half of current drugs exert their effects through a family of proteins called G protein- coupled receptors, and the targeting o
r will be incorporated into an array format, methods for fabrication from polystyrene will be developed, and the resulting fFCXHTS will be v
bricated from elastomeric polymer and optimized designs will be fabricated from polystyrene. The plastic fF-RTD devices will be validated u
he potential to generate an unlimited source of beta/islet cells for transplantation, however the biologic factors required for this process ha
he size of these tumors before, during and after treatment in individual mice. Prostate cancer is the leading cancer disease and is the secon

t enables safe and effective strength training with velocity-controlled shortening contraction (VSC) and lengthening contraction (VLC) trainin
ovement-responsive cage that we built, and began to test, during Phase I studies. The project milestones outline the successive addition of

R proposal we plan to investigate 12 ene reductases. The gene encoding each enzyme will be cloned and conditions for high expression in
it very easy to distinguish between the two. In 9 out of 13 benign lesions (70%) we detected a very small electric field and correctly predic
ecedented fexibility in placing a biopsy needle or other probes. Using the custom MR receiver coil, the proposed minimally-invasive, interv
m all members of the project team, including general productivity, information security, use of reference data, workfow, and computer-use
development of a non-invasive method to assay for the emergence of resistance would be a significant advance. We believe the best appro
ccessfully commercialize pWGA, we may be able to offer researchers with a means of amplifying samples with very limited quantities of in
ed as a result of the proposed project is expected to remove barriers in current methods, facilitate the adoption of new diagnostic procedu
have received requests from more than 40 scientists seeking to utilize PM technology in their studies of these microorganisms. This level of
cy departments. While originally based on a laptop computer for data collection and analysis, BIOMEC is currently in the process of miniatu
with anti- selectins, the impaired physiological circulatory parameters of animals with HS were significantly improved and the survival was
and adheres evenly to the walls, improving the adhesiveness between lacerated tissues and potentiating clot formation through the up-reg
me datasets from environmental models and global positioning system software, space-time joins across raster and vector datasets, exposu
mong health scientists. Phase I of the project will: risk maps from individual-level data and statistical tests to detect significant differences i
 s of cases and controls to identify geographic excesses of cancer risk, both in the study population itself as well as in relation to putative ha
er of systems activities (i.e. power transfer [RF-ID], chip interrogation, IOP data capture and storage, wireless data transfer, remediation, res

peptides produced by immunizing rabbits with recombinant peptide-immunogen fusion proteins. Characterize the antibodies to identify th
pes. We will then make synthetic peptides and compare their serologic reactivity to the corresponding recombinant protein. The new immu
e host and of the tick vector. We will carry out experiments both in the laboratory and in the wild. The fieldwork component of this project
markers. As a result, our proposed GFR test will be able to more quickly enter the marketplace. The project will further develop a diagnostic
ddition, these tools are necessary to evaluate the usefulness and safety of cell-based therapies.
udy will focus on toxicology, biodistribution, and in vivo stability, as well as further characterize the reagent. If Phase I research is successful
he serum, either unbound or bound to DcR3, has become an important issue. Therefore, we propose herein to develop a rapid ELISA and c
Undoubtedly, the positive outcome of this project will provide us with the rationale for further development of rhDcR3 for future clinical u
me for ophthalmic OCT imaging with handheld probes, and the robust design potential of FDOCT enables the implementation of truly porta
ha unit) and version 1.0 assay in clinical samples, in comparison to gold standard HIV viral load assays. 2. To develop a field deployable prot
DNA. (3) Use lsGG to replace a second large chromosomal segment in the modified strain produced in aim #2. The synthetic DNA donor seq
ng and thus to generation of fuorescence. Under this grant we propose to apply azoreductase to develop a powerful and versatile new rep
ain networks, and how the recruitment of individual neurons into synchronized population activity might underlie seizure and its cognitive
ert the synthesis system's acoustic inventory into an acoustic inventory that mimics the target speaker's voice. The training recordings can c
sentation of the lumen and mucosal bacterial patterns, then our diagnostic test will be the most feasible, noninvasive and easy test to asse

ricans. Our long-term goal is to have a measurable impact on the health literacy of the African American community using a culturally rele
ve patient friendly features. SUPRAER will be used to generate aerosols of surfactant, tobramycin, insulin and mannitol. The performance a
ototype system for general bacterial identification by improving our techniques for nucleic acid fractionation based upon relative organism
r improved biocompatibility and, hence, extended in vivo sensor functionality in rats. II. BioTex chemists and engineers will perform studie
apoptosis, caspases serve as important drug targets for these diseases. Among them, caspase-3 has been extensively studied for their impo
mation and entry into whole-cell recording configuration. We will use machine learning approaches to examine how a human patch clamp
elopment, and 4) hardware design and development. Smith-Kettlewell's Rehabilitation Engineering Research Center (RERC) will provide exp
computer-assisted joint replacement. Specific Aim 3 - Develop a proof of concept intraoperative TSA navigation system to aid in glenoid su

he creation of novel, fully active PEG-Cys-sFlt-1 analogues of defined structure and overcomes the problems of reduced bioactivity and het
berrations. This large stroke, combined with a Badal optometer design, will eliminate the need to use corrective lenses for each subject eye
ll provide background data needed to establish Carboximetry as a viable alternative or adjunct to the D-dimer to screen for PE in high-risk
e particularly useful for in vivo use due to the fact that they are not substantially absorbed into the body. In Phase I, Brighton Technologies
lly developed. The Phase- II studies aim to optimize, improve and perfect these promising molecules into actual therapeutic products again

ses micro-X-ray fuorescence to quantify the binding of drugs to proteins. It is a unique label-free system. Currently, the binding kinetics of o
ntly, leading to varying accumulation and disease susceptibility.
stems Voyager-DE STR MALDI-TOF and QSTAR XL MS/MS mass spectrometer. Caldera has access to machine and electronics shops. Caldera
engths. In the proposed SBIR Phase I timeframe, we will pursue two complementary high- throughput screens and evaluation of identified
ounds. (3) Select DJ-1 inducing compounds for preclinical evaluation in Phase II by characterizing their cytotoxic and neuroprotective effect

al trials. The project work would address sensor contamination and fouling; microfuidic design, initial product concept development, and o

that trigger the cardiac phenotype in other precursor populations. 2. Assess the human CPC' differentiation into cardiac muscle in situ
vel surface modification, (2) the in vitro optimization of nanoparticle surface composition of both shielding (PEG) and targeting (anti-CD19)
ll focus on transforming the existing proof-of-concept prototype cerebral oximeter into a commercial product. Furthermore, we will condu
l strengths and limitations; (2) to develop two DVDs that demonstrate the essential clinical components of BASICS program delivery utilizin
we also plan to infuse these mice with human adult mononuclear fractions to demonstrate specific need for HUCBC rather than the adult
Demonstration of human pancreatic endocrine progenitor cell expansion to a level appropriate for treatment of multiple patients with reten

erve-sparing procedure. The Specific Aims of the Phase 1 are: SA1 - Identify which cryogen is best suited for "CryoPellet(tm)" design; SA2 -
e Phase 1 are: SA1 Determine the effects of freezing on nerve cell viability; SA2 Determine the role played by apoptosis in freezing-induce
d liquid chromatography-tandem mass spectrometry methods. To demonstrate that we can evaluate the relevance of the sites we find, we

rrative The PhosphoSite(r) database catalogs modification of proteins by attachment of a phosphate group - a change that can affect many
ogy industry a better and more cost-effective platform on predictive toxicology and DMPK (drug metabolism and pharmacokinetics) profilin
eeds the complexity of small molecule libraries, will change current drug discovery strategies and accelerate the development of novel the
gram to include the development of genome-wide functionally validated human and mouse siRNA libraries. We propose to use our novel H
ase and algorithm for prediction of the most efficient siRNAs. Then, we will extend this program to include the development of databases c
wise lethal dose of Aspergillus fumigatus or pseudomonas aeruginosa. Furthermore, we have also demonstrated in preliminary studies atte

ating HIV-1, HBV and HCV from even highly diluted human serum samples, e.g., 20 RNA copies or 25 IU/mL. Isolated viruses could be lysed
del for cardiac safety. CDI was founded by Drs. James Thomson, Craig January, and Timothy Kamp, three noted researchers in the field
nclude identifying the different dosage levels of a prescription drug, reducing the background fuorescence in some drugs. The PVS system
a single laser wavelength, an important consideration for portable diagnostic instrumentation. Indeed, spectral multiplexing avoids the lar
th a medical industry partner.
hree dimensional representation of the arteries, and a forward looking architecture. In the program, the array transducer will be modeled, f
pe A' C6 prototype design is based upon a naturally-occurring C6 O-glycoside precedent (megalomicin) with notable antibacterial, antiviral
index. The synthetic studies will involve surveying new cardenolide aglycones that carry a subset of the original library of hexoses and pen
maximize the yield and viability of isolated islets after hypothermic machine perfusion preservation. More specifically, in the Phase I study a
ents in the technology used to determine the CBC for over 20 years. This application proposes the development of a novel means of prepa
say by examining the anti-EA in a set of antioxidants used in foodstuffs and plastics. Finally, CCi proposes to perform HPLC separation assay
ject has synthesized a series of novel CA4 analogs using SU5416 (a VEGFR signaling inhibitor) as a template. Among 25 novel compounds st
mated to be greater than $9 billion, growing in excess of 20% per year. Diabetes, including diabetic retinopathy, is quickly becoming an epid
), a major transcription factor up-regulating VEGF expression in diabetic retina. We have evaluated the efficacies of these compounds on re
of the test will be made possible by collaboration with Weill Medical College of Cornell University and the Oswaldo Cruz Foundation in Bra
idization and an enzymatic cascade detection system enabling (i) linear amplification of the target above each sensor and (ii) transduction
nutritional disorder linked to significant morbidity and premature mortality caused by other serious medical conditions such as diabetes an
ater contaminated by arsenic. Arsenic (As) is identified as the number one most hazardous substance on the 2001 CERCLA Priority List of
delivery is a significant public health risk whose prevalence has not decreased during the past few decades; the financial and emotional co
empirical feasibility assessment procedures will also be used to refine the TEACH Phase II design and build toward Phase III to create a fully
and support immune mechanisms. This project will develop tools that will enable improved diagnostics for autoimmune diseases and for i
arkers is based on an advanced label-free detection technology that we refer to as Grating-Coupled Surface Plasmon Resonance Imaging (G
etection system that is capable of rapid, multiplexed analysis of T1D antigen-specific T cells using dramatically smaller sample volumes than

and diagnosis, defining diagnostic criteria, and quantifying treatment protocol effects. The system should allow general practitioners to scr
liminary results from this and other laboratories have convincingly demonstrated that use of rodent brain endothelial cells and in general e
e conducted a needs analysis with caregivers and geriatric health professionals and developed the interface and content of the DementiaCa
dditional education, the positive response to and educational success of the initial module, we are requesting funds through a Phase II awa
le an IND application with the Food and Drug Administration for a novel muscarinic agonist with potential utility in the treatment of schizo
behavioral performance. In light of these findings, the overall hypothesis that forms the basis for this proposal is that cerebral microvascul
presentative infammatory mediators. Novel Intervention for Colitis: Infammatory Bowel Disease (IBD), more commonly known as Crohn's
y effects of ApoE for several years and have documented some of the mechanisms of anti-infammatory and neuroprotective effects of Apo
d dose of COG133 will be used in further experiments to characterize disease progression through biochemical and histological analysis. Bi
1) Specific Aim 1: We will verify the potential remyelination-promoting effect of COG112 in a cuprizone-induced demyelination model; 2) S
dels mimicking the PP-MS and RR-MS forms of human MS, respectively. In specific aim 3, we will decipher the molecular and pharmacolog
h as viscosity, cure time and exothermic temperature during cure) must be engineered to produce an adhesive that can be delivered in sma
as viscosity, Young's modulus, cure time and tensile strength) must be engineered to produce an adhesive that can be delivered in small vo
e in mice; 3) enable lower doses of vaccine to protect mice against a lethal challenge with infuenza virus; and 4) exhibit a transdermal tran
developed in Phase I and will be tested for its feasibility. In Phase II the assessment and training modules at the syllable level will be fully d

perating in pervaporation (PV) mode. Focus will be on PV since this is the simplest system for the end user. Once successful basic data on IP

mately to the synthesis of potent puerarin based SGLT1/GLUT2 inhibitor(s). We also plan to perform preliminary testing of the most potent

the computerized instrument will preprocess the outputs to create monoaurally or binaurally appropriate test signals for each outcome me
be mass analyzed is introduced continuously. This continuous introduction of air sample into the vacuum chamber of a mass spectrometer
easing demand, and a reduction in the availability of multidisciplinary pain programs. Thus, there is a great need for alternative forms of ca
using the fast mPBE solver to assess the salt-dependent behavior of complex-shape biopolymers in multivalent salt solutions. Research De
me in survivor animal surgical models. Task descriptions include preparation of sterile solder under stringent process controls, design and a

l. The objective of Phase I of this STTR proposal is to create a Finite Element Model (FEM) of human mandibles and of the device, and estab

LLFDI-CAT will fill a critical void for a feasible and psychometrically superior assessment instrument to be used in gerontological research wh
ilizer designs will be prepared incorporating the stakeholder feedback. Engineering analyses of the bench models will be conducted and th
ful and relevant to experiences they have had. The deliverable of Phase 1 will be a vertical prototype on kidney transplant programs that w
n through simulation studies; and 4) to demonstrate feasibility of the approach through a pilot study that will be performed at the Universit

utilizing phenomenological models that are based on first principles, (3) to conduct an animal study to demonstrate the feasibility and utili

pply Cell Xpress to bioprocess optimization and monitoring; and (4) automate and integrate the Cell Xpress process. Phase II success will re

an improve the success of cartilage repair procedures. This project represents a Phase I STTR to combine adult human stem cell and thre
ed T cell recognition of the tumor targets. We propose to develop a test to rapidly evaluate a chemical's ability to increase the body's immu
tion that EETs, products of CYP4X1, have anti-nociceptive effects gives us a unique opportunity in the area of pain management. This resea
sels, a process that requires a complex interplay of multiple cell types and growth factors. Thus, we will also evaluate adipose tissue-derive
uid such as liquid ethane. Protein assemblies as large as 200 kDa can, in principle, be made to tumble with sufficiently short correlation tim
ook and facilitator activities, and video/DVD scenarios will make STRIVE a fexible and easy-to-implement resource in a variety of settings, in
munity residential and outpatient substance abuse treatment facilities; 3) Provide an effective, cost-efficient, feasible model for improving
smetologists, and to help them educate their clients about TTM, as well as be designed to increase awareness and knowledge about TTM a
ase I, the research team will accomplish the following goals: (1) conduct formative research, including a needs assessment with the Adviso

behaviors; and (3) counselor, participant, and family materials for eight supplemental sessions. In Phase I, Danya developed the full conten
chieve these goals for continuous and discrete multilevel data with arbitrary dimension. The final result is a software library with fexible m

ne. Due to parent over-protection and medical services that focus on symptoms, these patients often lack supportive coaching on issues (e.
d viewer guidebook; 2) Design and produce the four 30-minute video programs and the printed viewer guidebook; 3) Conduct a randomize
essment with students, teachers, and experts to finalize content areas and product design. The product development period will be used t
umor models to insure the best cancer applications for the products.

research in the management of sleep behavior disorders in individuals with dementia for the formal or informal bedside caregiver. This qua
owth, migration, education and employment); and economic data (such as investment, and GDP), and other factors available at various spa
ials, currently under development, become available. The Phase 1 effort will build on existing bench top prototypes developed by Dental D
use than other student populations, and provide opportunities to reinforce training content through social infuence within stable young ad
the web-delivered training program to teach dentists and dental hygienists patient approach and behavior change strategies for this sensiti
this study specifically against P. falciparum, the most problematic human malaria variant, bRCQs should also be effective against the other
on about a locality's older population will help service providers assess the need for different types of housing and enable them to offer the
ettings, additional evaluations will be conducted in India, China, Guinea and Italy. FDA approval of the DRW HBsAg Rapid Test will not only
study is proposed here, in which doped diabetes biomarkers (representing a model diabetes patient sample) will be tested for detectability
monitoring of drug efficacy in patients. Phase I of this project will build on the success of preliminary experiments and will determine cond
nation $100 billion each year. ARemind will be a significant contribution to our country's health as an engaging system that reminds and a
s significant as it can provide a new means to manage this chronic and debilitating disease. SPIMA: Signal Processing for Individual Mood A
ent protein kinase (PKA), and the interaction of two members of the MAP kinase family, MEK and ERK2. These feasibility studies will lead to
proteins that interact, the interaction of the two proteins enhances the complementation resulting in increased a-gal activity. In this grant,
HuH7 and HepG2) of a LTT targeting tether to enhance uptake and transposition of a pKLAT2 transposon vector. HeLa cells will serve as a c
n animal model of FA? (ii) For the human trial, what is the clinically applicable methodology that will be used for introduction of FANC-enco

generated across a typical industrial facility. Phase 2 will also include the development of a web- based database management system that
ddition, as a prelude to Phase II research, compounds previously demonstrated to possess nematicidal activity at Divergence were tested ag
e. The evaluation of the prototype emphasizes image quality as a function of focus at multiple depths achieved with the liquid lens. Image q
his objective will be accomplished in three specific aims (aim 1 in Phase I and aims 2 and 3 in Phase II): 1) Develop prototype ThermoBLAST
We envision the potential commercial application as a dosimetry service to hospitals and medical centers. . Radiation treatment for cancer
of leukemia progress and response. Preliminary designs will be carried out for several applications during Phase I, and a mouse MRS plat- fo
eld strength, spectral resolution, and S/N. The net result is expected to be an order of magnitude reduction in signal acquisition time for m

hip with a thin motherboard and ADCs arranged into a vertical stack, modify the HgI2 deposition as required for the Dental imaging applica
h spectroscopic x-ray imaging, and potentially significant improvement in overall image quality. In Phase I we will develop and test a drift str

s obtained in populations of 118 healthy, 75 hypertensive, 30 diabetic and 50 stroke subjects. 3) To validate MMPF measurements using inv
l be developed to access more chemically diverse natural products (antibiotics, anticancer agents, immunosuppressants, or others) from p
proposal tries to investigate a novel approach to stop or slow down this catalytic reaction so that the high reaction rate can be greatly redu
been used sporadically and with limited success. Therefore, researchers and clinicians continue to seek a BCA method for use in pediatric
al number of pathogens but not discern between species. In previous studies, roughly 80% of clinical isolates from chronic wounds produc

orimetric or colorimetric mycotoxin sensors by integrating fuorophore or gold nanoparticle detection systems with the DNAzymes identifie
possibly in combination with an antimicrobial, this agent will protect tissue from further enzymatic damage, reduce the bacterial load, and
st method of producing biologically active SLPI to facilitate preclinical testing and potential commercial production of this intriguing human
ally stabilizing denatured proteins prior to complexing with GroEL. In this proposal, our first specific aim outlines our efforts to demonstrate
l validity of the program, and (e) social validity of the model. This project is relevant to public health because the number of individuals wit
 over current systems. Such rapid low cost sequencing could be used to obtain individualized information on predisposition to diseases and
s surface covered by a lipid bilayer. The new nanopatch technology offers the possibility of increasing measurement sensitivity at low frequ
board with established expertise in education assessment will strongly complement the company's existing strength in science education, m
hemometric analysis. Identification and quantification of any detected pesticides would be reported to the field technician. A single reader
en developed and demonstrated by Prof. Charles Martin's research group at the University of Florida. This STTR effort will team Martin's gr

essions, to ensure comparison at the same time point. All objectives of Phase I have been achieved: PIM yielded accurate quantitative info
vironment that should lead to improved behavior modification. Cost benefits include reduced time for caregivers to review behaviors of int
d majority of soil bacteria to produce natural products never before tested for antibiotic or other drug activities. The starting materials for t

ted contributors to affect prevention outcomes. These four components are interactive learning, refective learning, group processing of so
nd local communities can realistically access relevant and comparable archival indicators of substance abuse consequences and easily prod
an AAC device-mediated communication has been frequently noted. As a result of these frequent breakdowns, users of AAC devices repor
vide point measurements, and conduct a pilot clinical study on ex vivo breast tissues to demonstrate the feasibility and effectiveness of ou
ials will be produced for future in vivo and clinical studies. The project will be concluded after performing in vivo efficacy evaluations in swi
rade materials will be produced for future in vivo and clinical studies. The project will be concluded after performing in vivo efficacy evalua
f these requirements but not both. Soft x-ray microscopy in the so-called 'water window' allows resolution to 20nm for fully hydrated cell s

ction of target biological and chemical agents. Aerosol handling components will be developed by Enertechnix using engineering and
ailable field tests, such as colorimetric kits. During Phase I, favorable comparison to standard analytical laboratory analysis has already bee

ase I we will develop and evaluate a prototype that features a single drug, methamphetamine. We will recruit 180 museum visitors to view
develop and test them. The long-term goal of this project is to establish such a system for development of methods to not only prevent no

patients to forcefully exhale (spirometers), or are very expensive and very sensitive to airfow leak (forced oscillation, FO, such as IOS), or re
roduce gene targeted transgenic rabbits from these cells. The success of this project will establish the first germline competent ES cell lines
coagulation by the intrinsic pathway. We propose in Phase I to develop PK inhibitors that have defined potency, selectivity and pharmacok
stem, while Aims 2 and 3 are focused on adapting the technology and demonstrating its capabilities in the two fields of interest. Trellis Bio
ene delivery with both locally administered and systemically administered chemotherapy. We hypothesize that use of this non-viral gene t
r tissues. In addition, application of lacritin for 1 month showed that the response does not diminish with repeated application, nor do tox
w for the utilization of a new technology that will detect cancer-related splice variants from complex biological samples. In Phase II, we will
bination of public domain procedures for assay construction (e.g. ink-jet deposition of reagents and available nitrocellulose assay membran
cinated with BCG. Successful completion of this work will set the stage for Phase II development that will partner the vaccine with improve
techniques and (3) to demonstrate that reengineered individual FVIII domains have reduced immunogenicity in a mouse model of hemoph
sses, or can be used as a chiral selective detector for chromatographic systems. The Phase I research focuses on the characterization of bioa
s, we show that ethanol appears in the EBC, at concentrations similar to those measured in blood, following oral consumption of alcohol (3
ally diverse taggant candidates from GRAS compound databases that will likely generate appropriate EDIM(s) at doses currently permitted b
tion of vulnerable atherosclerotic plaques and monitor the progression of the disease. Information obtained from these studies will be ben
mat for high content screening.
ce more effective, more predictable and more reproducible soft tissue reconstruction.

pho-FAS would form the basis for the development of a cancer-selective FAS ELISA assay for the Phase II application. The early diagnosis of
r the emerging field of predictive metabolic engineering of industrial microorganisms. 1 PROJECTNARRATIVE Industrial Metabolic Engineer
ntify important genes, enzymes, and metabolic pathways for an important production process will allow metabolic engineers to impart rati
terference testing and UCBf measurements of samples treated with in vitro and in vivo phototherapy. The third aim will require new versio
ill have beneficial effects in the treatment of chronic wounds such as DFU's. ACT1 peptide has been shown to significantly dampen down th
target. Potential commercial applications in human medicine are substantial, starting with applications in biomedical research, where thes
is currently the size of a laptop computer. The low complexity of the testing platform will also enable the development of handheld units t

r the system's performance as nurses use it with their Spanish-speaking patients. During this stage, Sehda will record and transcribe all inte
potentially affect tissue growth and the ultimate function of the construct. Tests of high throughput tissue engineering in Phase II could ulti
luorous-tagged peptides and monosaccharides will be printed on a fuorous glass plate, and binding to the fuorescein isothiocyanate- labe
, Michlle High Throughput Intracellular Drug Screening Platform Project Narrative In the Phase I portion of this grant, we developed a reliab
ment instruments and practice resources include an audio option for the online English and Spanish versions of the SSP and the ESSP for Pa
truct a working prototype of the valve and conduct in vitro and in vivo tests. The three specific, measurable objectives for Phase I are to: D
nitial validation of these target genes will be rapidly achieved through a built-in reversible control of the gene perturbation mechanism. He
l enough for the large numbers of channels envisioned. Preamplifiers in MRI are different from other technical areas in the need for low-in
ch, this Phase I application outlines a strategy, based on our preliminary data, to develop a diagnostic tool for the relative assessment of tw
this grant application among the co-inventors (U.S. Patent #6,069,177, May 30, 2000). The Specific Aims of this grant application are to sy
Phase II.
Y) capable devices to support M-Code. Components of the test system will closely match the existing GPS infrastructure already in place to
nd deliver 3 prototypes: (1) use high accuracy laser rangefinders with inclinometer, speed/distance encoder, GPS and ground marker to get

braking on the eddy brake as well as the effects of braking on the ship. This model will also be used to demonstrate the thermal environm

t platform. Under Option 2, we would test the adapted PLADAR aboard the Firescout platform.
e framework facilitates rapid development and automation of analysis modeling processes, facilitating rapid simulation for design validatio
size; 4. be low cost and disposable; 5. require no battery replacement over their useful life; 6. provide early notification of possible damage

rrestrial application is not envisioned, the RPCT directly supports the current emphasis on robotic exploration and investigations of the geo
ouse activities.

ll help us gauge the difficulty of determining what chemicals are in a mixture based on the mixtures expression signatures. In Phase II, Eon
mmercial-scale production and use of an alternative fuel from renewable resources while reducing greenhouse gas emissions.

nt enhancement of the membrane efficiency and reduction in the production costs. This reduction was well in excess of the 33 to 50% redu
e experiments will help us gauge the difficulty of determining what chemicals are in a mixture based on the mixture&rsquo;s expression sig

by enabling commercial-scale production and use of an alternative fuel from renewable resources while reducing greenhouse gas emissions

nt enhancement of the membrane efficiency and reduction in the production costs. This reduction was well in excess of the 33 to 50% redu

s cost by 50%.

to the objective system design that is to be developed and demonstrated during Phase II of the program.
imate models, these measurements would help to reduce environmental risks to society; strengthen capabilities to predict climate, weathe
rate required for fux measurement. In addition, the analyzer requires far less calibration and sample preparation than currently available

xecution software and services; and NCMS will provide access to complimentary research and development programs. To ensure program
ting treatment methods. The final goal is to develop commercial systems to complement the exiting line of PolyGeyser® bead filter to provi
(e.g., endocrine disruptors), disease-causing microorganisms (E. coli), and potential biological and chemical threat agents (e.g., G- and V-se

in hybrid catfish production and would increase significantly the number of hybrid fingerlings available for stocking.
ts and additional site identification for field trials.

eradication programs.

r assessment.
als. We will be also be evaluating valves made from bisphosphonate-modified polyurethanes, which have displayed substantial resistance t

net technology being used by ABQMR. The Phase I goal is to obtain high resolution in vivo pulmonary MRI with a compact permanent mag
of the effort by identifying salient HHA beliefs, generating core content and design documents, evaluating those documents through end-u

t to fail under active use. Currently, there are no commercially available backrests that have the capability of being adjusted by the user wh
cal compound databases with biological databases will be developed. The resulting analysis methods are expected to make a significant im
al disclosure risk associated with linking synthetic SSA data to the RAND-HRS general-release ?le. If the confidentiality-protected data prov
brication processing steps ii) Develop interconnect capability optimized for manufacturing efficiency, iii) Develop beam forming and focusin
cells. Continuous light exposure and A2E (a RPE lipofuscin generated as a side-product during the visual cycle) accumulation are two major
(photo)toxicity of environmental toxins, and to have this assay incorporated as a part of the regulatory framework for the commercializatio

t beneficiaries across Medicare and Medicaid data sources consistent with Census? special protocols; (3) evaluate the merits of carrying ou
dministrative data sources maintained by CMS (i.e., across Medicare, MDS and Medicaid); (3) conduct a pilot project demonstrating the eff
odified nanoparticles, and demonstrate the feasibility of preparing representative glyconanoparticles; 3) to characterize the glyco-nanoparti
better understanding of the roles of carbohydrates in biological processes. This proposed research seeks to develop a new tool for biologist

's prototype achieved a maximum FFR of 0.78, as compared to current devices which average an FFR of 0.2. The end result is that children
2 lead compounds and validate the A2AR receptor as a target for treating cocaine addiction. Our long term goal is to bring a new compoun
m islet exhaustion due to the transplantation of insufficient beta cell mass. It is our hypothesis that the current method of mechanical shake
affinity to the epsilon -toxin pore. The designed compounds will be synthesized and tested in vivo and in vitro with the eventual goal of fin
(OSA) from healthy subjects. The AMP characterized individual profiles of alertness and memory impairment and quantified the ameliorati
ted. Dentists and dental sleep specialists represent an important access point for identifying patients with undiagnosed OSA. Although man
aims of this research include 1) demonstrating proof of concept of the ITD to treat IDH in a randomized, blinded, parallel design clinical tria
rted, mixed, assayed, and disposed. Fluorescence assays for determining activities of enzymes involved in Pompe, Fabry, and Hurler disease

for chronic care? Self management tools may now go where patients go. In other words, they can be mobile providing on- the-spot inform
ogressive dementia. The use of EEG provides a low cost alternative to more sophisticated tools like MRI and PET to distinguish characteristic
care providers in the home. Technology-dependent, chronically ill children are more frequently affected by acute, life-threatening illness th

ble computing and cell phone devices for many years to come. Recorded motion data are automatically processed and characterized into a
mpletely specified the IC requirements, designed the analog building block circuits, designed a custom wireless network protocol, and perfo

ons in the United States. Furthermore, three to five percent of the population will have non-febrile seizures at some point in their life. Radio
m levels. These results highlight GP88 as a novel targeted therapy of breast cancer via the development of anti-GP88 therapeutic neutralizin
signaling proteins in both normal and phosphorylated form. Our options for breast cancer diagnosis and treatment will increasingly take ad
of the purified peptides will be used for rigorous optimization and standardization of all technical and clinical performance measures for th

2 copies of an E1 expression plasmid with very limited overlap with conventional adenoviral vectors. We propose to rigorously test the RC

as was chosen since these patients receive radiation therapy as standard of care following stereotactic biopsy for confirmation of diagnosis
will be deployed in clinical research to demonstrate the instruments' utility and ease of use, and to better understand the application of bi
our just-completed phase II SBIR project we developed inhalers using several different designs, and selected two optimized designs for SBIR
not been reported before, but is anticipated to work very well based on the highly lipophilic nature of artemether. Further, we anticipate t
cacy in animals will lead directly to clinical phase 2 proof of concept in man during the SBIR Phase II renewal. Thus this project proposes a m
normal bedding. We now propose to create a new apparatus, DiscTreadmillTM through the integration of EEG/EMG and noninvasive piezo
based wireless modular devices (modules) for cognitive and basic neurobehavioral assessments in a mouse homecage. These modules inclu
aggregates that are too large for lymphatic clearance; 2) inducing adhesion of injected cells to native cells and matrix components; 3) prov
time frame. In aim 1, we will synthesize candidate peptides that have binding affinity for vancomycin. In aim 2, we will synthesize a series o
e expect that coating bone graft materials with binding peptides will significantly improve their ability to retain exogenously delivered oste
, suspensions of mixed cell populations, and human bone marrow aspirates. Finally, we will develop a chemical release system for bound M
le to determine any significant postural deviations from the baseline requiring intervention. Again, this will allow for early intervention, bef
nd regenerative site, typically leading to exposure of the regenerative site to the oral environment. The objectives of this Phase I applicatio
g domain 1 (D1) of the core protein. In situ heparan sulfate glycosylation of the expressed core was validated, and new bone formation app
rm, Collective Simulations would include other health education topics such as infectious diseases, nutrition, and physical education. Additi
ss distribution of particles by size. The aerosol particulate matter sensor uses a piezoelectric sensing element. The crystal vibrates at its high
cially for young users and users with more limited vocabulary and literacy skills. Aim 2 - Implement and test novel speech processing techn

the AIKO neutral antagonist as an early indication of its safety and tolerability for humans. Research will be conducted using established ro
and empower collaborative research at Academic Health Centers (AHCs), government agencies, Contract Research Organizations (CROs), a
s. These spacer units will be end-capped with non-degradable cross-linker units which hold the polymer chains of the hydrogel together u
rom Quidel Corporation; protein array expertise at Argonne National Laboratory; and clinical practice at Little Company of Mary Hospital. S
nfuenza in neat and amended nasal swabs, throat swabs, nasal lavage and/or sputum clinical samples in preparation for 510K submission w
oyed feedback control. The design will be tested on the bench top for reliability, consistency, and ability to maintain pH, CO2 and O2 levels b
nfrared sensitivity than the PMT. The goal of the Phase I SBIR is to develop a prototype 24 well plate reader using the RMD Geiger mode Av
monstrate the integration of the photon-counting detector, and measure clinically significant concentrations of TBI biomarkers in model sa
solution. When combined with a suitable readout, this scintillator will enable realization of the high speed, large area, high resolution detec
ection for absorption of thermal neutrons. It means that only very thin layers of this material (200 microns or less) are required for nearly 1
escent contrast agent. The proposed contrast agent will target endothelial cells lining the vasculature or breast cancer cells. It will be locali
he proposed instrument will be used by manufacturers, distributors, public safety personnel, and possibly retail stores and parents, to exam
e comparable to that of a single crystal. In Phase I we will confirm that the process that has already been established for alumina is adapta

nd spatial resolution detector, and other technologies being developed under this program is well over one hundred million dollars. A signifi

on diffraction studies. The proposed detector could be employed at any neutron source facility and would help to advance basic research i
good from bad facts. Our Phase II proposal focuses on developing techniques to reason over such fact heavy analysis by exploring soft clus

of the conventional agglutination methods. Successful completion of these studies will make available all of the technology needed for a s
will test the overall hypothesis that transdermal delivery of a cannabinoid, cannabidiol, may protect against alcoholic neural and behaviora
aphylococcus epidermidis. The plan will be completed with an in vivo evaluation of prototypes using a model of central venous catheter in
tive (FN) rate from 0.3-30%. Despite improving scanner technology with excellent near-field imaging and an increasing number of positive
the radiolabeling efficiency and purification of the nuclear targeting peptide with 212 Pb the parent of the alpha emitter 212 Bi, 2) examine
rradiations required for the production of Th-228 will be identified. As a result of implementing a Phase II grant, curie quantities of Ra-223
canavalin A (ConA) and jacalin as model sugar binding proteins; 4. Test the four spot prototype system and generate binding concentration-
iscovery and primary biliary cirrhosis. Similar studies will be carried out on other vasculitis autoimmune diseases in association with Dr. Pet
ng drug resistance test based on MASSIVE-PRO will be developed. A key aspect of this test will be the ability to routinely detect and charact
l of CRC patients. Significant improvements in the MASSIVE-PRO technology beyond the Phase I goals were also achieved including: i) Abili
pproach, based on mass spectrometric analysis of in vitro expressed proteins (MASSIVE-PRO), is able to additionally scan for missense mut
the isolation and quantification of miRNA from PrCa diagnostic samples. We will optimize procedures for the extraction and detection of m
PDs, and 2) is predictive of therapeutic outcomes and thus useful in selecting between different treatment options. The availability of this a

d GPCRs, including drug screening, biochemical studies, and studies of receptor stability and folding. Specific Aim 1. Develop a novel clas
ands by means of automated voice messages. As a result of the work proposed here, hospital acquired infections, those acquired after adm

LF, Ang 1170 reduces mortality, and attenuates hepatic injury. We have since constructed a structural library around Ang 1170 comprising 2
 round these small molecules. The goal of this Phase I application is to couple in vitro targeted proteomics to in vivo bioefficacy studies in o
up to 12-18 hr for lung transplantation using our lead SF/HGF mimetic as an additive to current preservation solutions. Preliminary data ind
odels of human glioma. Recent data have demonstrated that the activity and selectivity of ANG 797 can be improved by modifying substitu
py because of instability in solution, and cost-prohibitive production schemes. Angion Biomedica Corp. has identified a small molecule com
vation and inhibits downstream signaling events initiated by its ligand, hepatocyte growth factor/scatter factor (HGF/SF). Moreover, Ang797
f this small molecule mimetic of HGF/SF represents a highly innovative approach for the treatment of SCI, with significant clinical potential

ects the imposed nutritional requirements that are apparently met only in the cancer cell milieu. S. typhimurium A1 is a double amino acid

defense, and biomedical research industries. The economy and speed with which novel peptides and proteins may be produced from a UB
y = 90% with a test duration = 10 minutes. The University of Alabama at Birmingham and Johns Hopkins University will serve as clinical test
of a suitable PG treatment formulation, and (ii) initial mouse studies to evaluate efficacy. This involves screening candidate PG structures in
eparation in serum and liver homogenate, determination of maximum tolerated dose of the formulated drug in mice, and evaluation of the
neos SleepCorder has the potential to greatly simplify the way sleep apnea and related conditions are diagnosed and treated, with lower c
-treated rats. No toxicity to the animals was observed in either model. These studies provide the first proof-of-principle demonstration tha
th a modified form of core streptavidin, modification of a cell membrane with biotin, and decoration of biotinylated membrane with chime
uvant effect, ineffective delivery of TAAs to professional APCs, and/or the presence of significant immunoinhibitory immune evasion mecha
efficacy to induce an immune response in C57BL/6 mice. Successful completion of the proposed experiments will be the first step along th
e a universal obstacle to all siRNA therapeutics is the delivery of the molecules into the cells, APMS offers the potential of revolutionizing th
e Crystal Finder(tm) microscopic workstation with Detect-X(tm) technology will be designed and built by Appalachian Electronic Instrumen
rug Pharmacology, and Airway Management) will be implemented using interactive Flash components. The modules will be made available
a simulated ICU to assess the status of a patient in 4 different scenarios. Performance of the participants in the simulation will be evaluated
ent optimization techniques so that the display's models predict drug combinations that will result in a rapid wakeup by the patient while m

generation instrumentation that upgrades this system. In consultation with the inventor and cooperation with Dr.s Charles Apperson (NCSU
n gene expression caused by exposure to contaminants, and it is clear that contaminants have unique genetic signatures. Because many con
drug or combination drugs eluting self-expanding metallic stent. The drugs chosen are multi- targeted and have proven anti-tumor activity
on- making, decrease medical litigation, and improve enrollment for clinical trials.

omic research by ensuring that the precious liquid samples are less time consuming to inventory and access, are contamination-free, maint
of a knowledge base supporting drug discovery and development research. It will bring together molecular, cellular, and clinical aspects o
pitope that may be an effective target for immunotherapeutic intervention. In this application, we propose further preclinical development
l produce a novel fusion gene encoding a lysosomal enzyme and a genetically engineered molecular Trojan horse, which will allow the prod

going education will be performed, and necessary engineering documentation will be prepared in accordance with regulatory requirements
scularization. Therapeutic stem cells is a relevant new technology being developed to overcome the shortcomings of several current techn

or injection. Integrate an existing robotic needle driver with the mouse holder on the same platform. 2. Manufacture a new needle holder
nocturnal alarm will be evaluated in preparation for a potential Phase II development effort. Hypoglycemia is a potentially life-threatenin
cibility and accuracy of detection of OP-modified proteins in actual serum samples will be determined. The data generated will guide the d
m therapeutic behavioral and histological benefits of MAPC grafts in the rat HI injury model, i.e., 6 months post-transplantation with safety c
ptable, injectable, water-miscible solvents/vehicles. Upon subcutaneous injection, the buprenorphine base will precipitate at the injection

called MARA, which also can use a single set of PCR primers, can be multiplexed successfully for 750 separate targeted sequences across n
many environments) the need for sound-attenuating rooms; 3) decreases inter-subject variability; and 4) increases comfort. In addition to m
linical use. Moreover, although it may be known that the side effects can be reduced or even abolished by alterations to the structure of a
most drugs do not penetrate sufficiently into the inner ear and therefore cannot be effective. Because corticosteroids have the potential to
ormulate sustained release suspensions of tacrolimus (TAC) and cyclosporine (CsA); to test the in vitro release characteristics of these form
neurology. We have experience in collaboration with large pharmaceutical companies leading to the approval of novel drug delivery system
with increased solubility, long plasma half-life, and potent antagonist activity. These agents should be effective for treating pulmonary fibro
of AD and mild cognitive impairment (MCI) patients. Successful accomplishment of these studies will yield an innovative radiopharmaceuti
f a biomarker for beta cell mass (BCM) would represent a significant milestone and a large commercial opportunity for diagnostic imaging o
ctional assay for motor axon regeneration is not available in other previously developed model systems. Feasibility of processing long multi
ople. Our preliminary data show efficacy for the prevention of CIPN with continuous subcutaneous administration. Here we will test efficac
milestone-driven and at the conclusion of each milestone the Senior Executive Team (SET) will review the results and recommend one of t
and a specific ELISA assay for its sensitive detection was developed. Proof-of-concept data to support the hypothesis that both biomarkers a
g values for Cronbach's alpha = 0.70 and item-total correlations in the range 0.30-0.70, which are the generally recommended values. Add
h to assess CNS function. In the past 25 years, an extensive literature has shown that motility, first of the fetus and subsequently of the you
research". As further support, the Joint Council on Accreditation of Healthcare Organizations (JCAHO) has declared pain the 5th vital sign.

prototype will be produced, standardized and then tested for stability and reproducibility. Task 2. Evaluate the biological indicator

a transparent software front end to the engine, and finally to evaluate the performance of the prototype on large-scale tasks in bio-sequen
ese programs and the likelihood they will be used in a variety of different settings. If the clinical trial shows that the CDCU program is effecti
clinical trial with a 12 month follow-up to assess its effectiveness. The study will be an additive design, comparing OA and SMART Recover
HSI-A for criterion-related validity using concurrent measures; 4) Assess the reliability of the HSI-A through the use of internal consistency,
treatments exist. Increasing the availability of such treatments requires widely available and effective training materials that will facilitate
of feasibility, we will substantially expand the multimedia program and its evaluation in Phase II. Although empirically-based treatments do
d receptors, and the targeting of these receptors has been especially useful for the development of drugs used to treat neurological disord
d the resulting fFCXHTS will be validated for identification of compounds that inhibit neutrophil migration. The migration of cells from the b
F-RTD devices will be validated using assays for key tumorigenic processes, including cell proliferation, apoptosis, and invasion using mamm
ctors required for this process have been difficult to ascertain partly due to the lack of stage specific in vitro cell assays. This phase I propos
g cancer disease and is the second leading cause of cancer death in men. However, treatment options for the disease are limited. Bexion Ph

gthening contraction (VLC) training protocols. The system provides programmable variable-resistance force target trajectories across the ran
utline the successive addition of capabilities to this cage, including automated blood sampling, programmed dosing, and physiological data

onditions for high expression in a bacterial host will be investigated. A thorough examination of the substrate range, chemo-selectivity (par
lectric field and correctly predicted in a blinded study they were not malignant. During this Phase II SBIR we will refine the design of the ha
posed minimally-invasive, interventional system will make use of 3D information provided by MRI to allow unprecedented fexibility in acce
ta, workfow, and computer-user interactions. Phase I, Specific Aim 2a will complete evaluation of scientific practices in two representative
ance. We believe the best approach to solve this problem is to assay circulating epithelial cells (CEC) for these mutations. We propose t
with very limited quantities of input DNA without loss of genome coverage. Indeed, pWGA uses a virtually complete replisome and thus ma
ption of new diagnostic procedures, and reduce the cost of existing methods. This research will lead to the development of improved techn
ese microorganisms. This level of scientific interest documents the need and potential for commercialization of the technology that we are
urrently in the process of miniaturizing the electronics and completely interfacing the device with a handheld PDA. The next steps in comm
improved and the survival was significantly increased in treated animals as compared to control. We propose to demonstrate, in a non-he
lot formation through the up-regulation of P-selectin. Our specific aims are to demonstrate in two ex vivo models: a) that the upregulation
ster and vector datasets, exposure calculations in a spatio-temporally-resolved manner, and quantification of uncertainty in the exposure e
o detect significant differences in cancer rates among sub-populations and across space. into the software: TerraSeer Space-Time Intelligen
 well as in relation to putative hazards such as point-source releases of carcinogens. Cancer Clustering for Residential Histories Relevance: T
ss data transfer, remediation, resolution, etc.) involving methods researched and determined in the successful portion of Phase I. These seq

erize the antibodies to identify the best overall carrier immunogen. In Phase I we will identify new immunogens which can be recombinant
mbinant protein. The new immunodiagnostic peptides discovered will be added to an improved VlsE-IR6 peptide to develop new, more sen
dwork component of this project will be performed at the Institute for Ecosystem Studies (IES) in Millbrook, NY. In a subsequent Phase II SB
will further develop a diagnostic test to measure kidney function. The test will utilize well-known and widely available analytical technolog

. If Phase I research is successful, Phase II research will expand toxicity evaluation in a non-rodent model as required for IND filing with the
n to develop a rapid ELISA and characterize it so that the assay can detect a total TL1A expression even in the presence of excess level of D
ent of rhDcR3 for future clinical use. If DcR3 can be effective for treating patients with sepsis, this will increase the success rate of therapy t
he implementation of truly portable systems. Bioptigen, Inc., a startup company affiliated with Duke University, has marketed state-of-the- a
o develop a field deployable prototype instrument (beta unit), and 3. To evaluate the field deployable unit for accuracy, detection threshold
#2. The synthetic DNA donor sequence, which has already been prepared and functionally expressed in E. coli, encodes the biosynthetic pa
a powerful and versatile new reporter technology. A number of assays can be envisioned employing the azoreduction mechanism, includin
underlie seizure and its cognitive consequences. Although electrode and surgical technology has advanced so wideband (field and action po
ce. The training recordings can consist of old home videos, or fragmented recordings produced during periods of intact speech, provided th
oninvasive and easy test to assess dysbiosis. Patients can place their stool on the cards (or physicians can place the stool on the card after r

ommunity using a culturally relevant and effective medium to improve public health and decrease health disparities. Based on the successf
nd mannitol. The performance and output aerosol characteristics will be compared with competitive marketed products with FDA approva
n based upon relative organism abundance as well as heuristic approaches for organism-mixture analysis. The anticipated result of this stu
nd engineers will perform studies to optimize a pre-sterilization formulation protocol of sensor by freeze-drying/vacuum-packaging. III. BioT
xtensively studied for their important roles in apoptosis and necrosis in many tissues. The development of multi- color cell permeable and
mine how a human patch clamp expert interacts with the patch clamp system in order to develop a model that will provide parameters tha
ch Center (RERC) will provide expertise for the human factors portions of the project. Blindsight will design and build the device hardware f
gation system to aid in glenoid surface preparation and implant placement, including incorporation of optimal bone registration parameters

ms of reduced bioactivity and heterogeneity when proteins are modified using standard amine-reactive PEGs. During Phase I we identified s
ective lenses for each subject eye and allow unprecedented in vivo imaging of the human retina. Researchers and clinicians have been unab
mer to screen for PE in high-risk patients. The condition of clots in the lung, termed pulmonary embolism (PE), is the second leading cause
n Phase I, Brighton Technologies Group developed and characterized a novel antimicrobial nanocoating (AMNC) based on gas-phase depos
ctual therapeutic products against oral microbial infections. The Specific Aims are: 1): Anti-S. mutans STAMPs will be optimized for stronge

urrently, the binding kinetics of only a few proteins and their inhibitors can be measured accurately. Most proteins do not have a readily m

e and electronics shops. Caldera facilities meet environmental laws and regulations of federal, state, and local governments relating to: airb
ens and evaluation of identified active compounds, as outlined in the following specific aims: (1) Identify compounds that block or reverse
toxic and neuroprotective effects. Our goal is to identify at least one compound that induces DJ-1 expression at micromolar or lower conce

uct concept development, and other aspects of device engineering. Subsequent Phase 2 work and commercialization plan would include t

tiation into cardiac muscle in situ, following ischemia- reperfusion injury in immunodeficient mice. 3. Assess the human CPCs' differenti
(PEG) and targeting (anti-CD19) moieties, and (3) the in vivo characterization of nanoparticle pharmacokinetics and distribution in a mouse
uct. Furthermore, we will conduct validation and clinical outcome studies to demonstrate the effectiveness of our commercial cerebral oxim
BASICS program delivery utilizing the unique technical features of digital video; and (3) to assess the feasibility, utility, and commercial pot
or HUCBC rather than the adult mononuclear cells in order to observe these immunomodulatory and therapeutic effects. Based on these
nt of multiple patients with retention of progenitor markers (including Ngn3 and Pdx1) and the ability to form dithizone positive islet-like st

or "CryoPellet(tm)" design; SA2 - Determine the efficacy and feasibility of the "CryoPellet(tm)"; SA3 - Design a prototype CryoInjectTM Syste
d by apoptosis in freezing-induced cell death of neuronal cells; SA3 Determine which novel agents can be used to protect nerve cells from
levance of the sites we find, we will collect and present information about known and novel human acetylated-lysine sites in an easy-to-us

- a change that can affect many cellular processes, including the transition from normal cell to cancer cell. We are improving PhosphoSite(
m and pharmacokinetics) profiling.
te the development of novel therapeutics. We propose to use our novel bioactive peptide HTS resource to delineate the processes which u
s. We propose to use our novel HT RNAi resource to delineate the processes which underlie deregulated proliferation in cancer cells, and to
the development of databases comprising a genome-wide FV mouse shRNAs without off-target activity. The FV shRNA databases will be us
trated in preliminary studies attenuation of histologic changes in the gastrointestinal tract and protection against death following higher do

L. Isolated viruses could be lysed in a PCR compatible buffer and directly used for detection using PCR or other technologies. The proposed
ee noted researchers in the field of human stem cells and cardiology. Dr. James Thomson was the first one to isolate hESCs and remains a le
e in some drugs. The PVS system has the potential to lower the cost of delivering prescription medicines to consumers as well as improving
ectral multiplexing avoids the large footprint associated with spatial multiplexing. In general, SERS nanotags are of great benefit to the poin

ray transducer will be modeled, fabricated and evaluated using in vivo animal studies.
h notable antibacterial, antiviral and antiparasitic activities while, the 'type B' C9 prototype design is based upon non-carbohydrate polyeth
iginal library of hexoses and pentoses; and carrying out post-neoglycosylation chemistry at selected positions in the attached sugars using o
specifically, in the Phase I study a new proprietary solution (Unisol) will be compared with current standard organ preservation solutions (K
ment of a novel means of preparing and analyzing blood samples to determine the CBC and white blood cell differential count using comp
o perform HPLC separation assays on some reference test chemicals to confirm that their anti-EA is not due to contamination and to enhan
. Among 25 novel compounds studied, two promising CA4 analogs displayed more potent anti-tumor activities than CA4 and SU5416. We h
athy, is quickly becoming an epidemic in the industrialized world. About 18.2 million Americans have diabetes, with 2.7 million new cases in
cacies of these compounds on retinal vascular leakage and retinal neovascularization (NV) in two independent DR models. The results show
Oswaldo Cruz Foundation in Brazil - the largest research institution in Latin America. The collaborating investigators have developed uniqu
ach sensor and (ii) transduction of this specific recognition into an electrical signal, which will be measured using a simple amperometric d
al conditions such as diabetes and coronary disease. Acetyl-CoA carboxylase, a key lipid metabolic enzyme, is being investigated as a potenti
the 2001 CERCLA Priority List of Hazardous Substances (ATSDR 2001).Today, arsenic poisoning is one of the major environmental threats w
; the financial and emotional cost of premature delivery has been on the increase at the same time. Our project aims to make a clinical tes
toward Phase III to create a fully-functional TEACH product that can be directly productized according to our commercialization plan, and w
r autoimmune diseases and for infectious diseases.
Plasmon Resonance Imaging (GCSPRI). This chip-based technology makes it possible to cost-effectively measure hundreds of analytes sim
lly smaller sample volumes than current methods. The major advancements of this system will be the ability to visually detect antigen-spe

allow general practitioners to screen for PD. The MPPS will consist of small, lightweight, telemetry hardware modules and a clinical base sta
endothelial cells and in general endothelial cell lines from non human sources as models of clinical pharmacology are fawed. We propose
e and content of the DementiaCareCentral prototype. We also conducted two rounds of usability testing with caregivers to evaluate the we
 ng funds through a Phase II award to complete the remaining 5 modules, evaluate those modules for ease of use and effectiveness of cont
utility in the treatment of schizophrenia. The overall goal of the proposed research is to develop new compounds for the treatment of psyc
osal is that cerebral microvascular fibrillar Aa deposition promotes neuroinfammation in the absence of fibrillar plaque amyloid. The aim o
re commonly known as Crohn's disease and ulcerative colitis, affects approximately 1 million Americans with infammation of the intestine
d neuroprotective effects of ApoE and derivatives. These investigations have lead to isolation of an anti-infammatory/neuroprotective pep
mical and histological analysis. Biochemical disease progression will be monitored through determination of systemic infammatory cytokine
uced demyelination model; 2) Specific Aim 2: We will examine the effect of COG112 treatment on OPC (Oligodendrocyte Precursor Cell) pr
the molecular and pharmacological mechanisms underlying the effectiveness of COG compounds in the following aspects: 1) if COG compo
sive that can be delivered in small volumes by injection in an operating room environment while meeting established performance require
that can be delivered in small volumes by spray in an operating room environment while meeting established performance requirements.
nd 4) exhibit a transdermal transport rate across human skin ex vivo sufficient to permit activation of human skin DCs in vivo. If our efforts
t the syllable level will be fully developed. They will be tested with ESL learners from a variety of language backgrounds. If the novel task u

Once successful basic data on IPA-water in PV is obtained we will expand the evaluation to other pharmaceutical solvents and also evaluati

inary testing of the most potent lead compounds for their ability to improve glucose tolerance in obese mice. There are three specific aims

test signals for each outcome measure. The instrument will be designed to interface with all commercially available CI processors and will u
hamber of a mass spectrometer requires large and heavy vacuum pumps employing differential pumping methods. This makes them heavy
need for alternative forms of care. The goal of the proposed project is the development of one such alternative, the Pain Self- Manageme
alent salt solutions. Research Design. The Phase I research plan addresses the high-risk elements of the overall Phase I and II endeavor by d
nt process controls, design and assembly of a compact preclinical laser systems, optimization of a laser hand piece and perform ex vivo and

bles and of the device, and establish the least robust form of the device to be used in humans that is able to withstand a range of external

sed in gerontological research where outcome measures are needed that are comprehensive, sensitive to change, and practical. Relevance
models will be conducted and their ability to move a 113 kg human dummy in a path simulating a transfer from a wheelchair into and out o
dney transplant programs that will integrate the analytical models with a web-based interface which will incorporate user feedback. Phase
will be performed at the University of Cincinnati's Neuromotor Recovery and Rehabilitation Laboratory at Drake Rehabilitation Center (Cincin

monstrate the feasibility and utility of the sensor and to examine the sensor performance, and (4) to perform a preliminary investigation of

process. Phase II success will result in an automated and broadened Cell Xpress application with large, near-term market potential for biop

e adult human stem cell and three-dimensional weaving technologies to create a layer of cartilage that can integrate with bone. The two pr
ility to increase the body's immune sytem in its capacity to recognize and kill melanoma tumor cells. The goal of these investigations is to fi
of pain management. This research team is poised to begin these studies as the tools, techniques and experience are in place to develop n
o evaluate adipose tissue-derived cells with the potential act as mural cells and mural cell precursors. Finally, we will evaluate the number a
sufficiently short correlation times to allow the full battery of existing triple resonance techniques to be applied, even without benefit of d
esource in a variety of settings, including schools, support groups, and advocacy groups. In Phase I of the project period, we will conduct fo
nt, feasible model for improving client confict resolution capacities; and 4) Offer an innovative program, based on concepts adapted from
ness and knowledge about TTM among clinicians and provide tools to help them educate and treat their patients. In Phase I, we will establi
eds assessment with the Advisory Panel and staff representatives from the National Alliance for the Mentally Ill and focus groups with clini

Danya developed the full content for the facilitator's guide and 12 core treatment sessions, and conducted an Advisory Panel content revie
 software library with fexible multilevel modeling approaches for the analysis of complex multilevel data. The software will be useful to bio

upportive coaching on issues (e.g., alcohol-and tobacco-related risks, sexual health, infection control, pain control, career prospects) that c
debook; 3) Conduct a randomized controlled field trial to measure changes, after exposure to the Living with Borderline Personality Disorde
velopment period will be used to complete the Teacher's Guide, video program, and accompanying CD-ROM. Once these components are

ormal bedside caregiver. This quality training will benefit the long term care industry by relieving the burdens of existing workers, facilitating
er factors available at various spatial levels. Both spatial modeling and standard demographic estimating techniques will be developed and
rototypes developed by Dental Designs of Dallas. Flexible medical endoscopes will be modified for use in MIS. Methods for soft tissue debr
infuence within stable young adult social systems. Our Web-based program will have several advantages: (1) wide availability independen
change strategies for this sensitive issue, and conduct developmental and formative evaluations of the prototype. The formative evaluation
o be effective against the other human malarias. Although there may be a very thin profit margin to be had some 'endemic markets', there
ing and enable them to offer the best mix of home and community-based services, health services, and other assistance. It could also prov
W HBsAg Rapid Test will not only pave the way for commercialization of the product in the U.S., but will also demonstrate the principle that
e) will be tested for detectability at clinical sample level concentrations. The proposed study will use five specific diabetes protein antigens
eriments and will determine conditions for performing the initial, phage display steps of the DCP process. The format of column chromatog
aging system that reminds and assesses adherence to medications for patient with HIV/AIDS. This system can be expanded to motivate adh
Processing for Individual Mood Assessment SPIMA will make a significant impact on public health by providing a simple and elegant way to
ese feasibility studies will lead to future phase II SBIR studies to develop EFC as a kinome-wide assay system to detect novel allosteric regul
eased a-gal activity. In this grant, we will provide proof of principle of the universality of the assay by developing EFC to measure activation
ector. HeLa cells will serve as a control for cells that lack appropriate liver-specific receptors. 3: Evaluate the efficiency of a LTT targeting tet
ed for introduction of FANC-encoding transposon DNA into human hematopoietic stem cells (HSC)? There are two Specific Aims: Aim 1. Eva

abase management system that will allow the system to be seamlessly integrated into the workplace without a burden on management. Fi
vity at Divergence were tested against Brugia spp. in vitro, with some compounds showing promising macrofilaricidal effects. In the current
ved with the liquid lens. Image quality will be measured in terms of resolution and distortion. In Phase II, we plan to complete developmen
evelop prototype ThermoBLAST code modules. 2) Integrate component modules into a single application with appropriate GUI. 3) Integrat
. Radiation treatment for cancer and other conditions involves exposing humans to potentially hazardous high energy radiation. This resear
hase I, and a mouse MRS plat- form will be designed in detail, fabricated, and tested at 100 K. A novel hybrid coil design will reduce sample
n in signal acquisition time for many applications in biological macromolecules. The Phase I will demonstrate the feasibility of the approach

d for the Dental imaging application, and complete and test a full product prototype. The product we will develop will help Dentists detect
e will develop and test a drift structure for each individual pixel element to greatly increase the count-rat capability of the detector system

e MMPF measurements using invasive measurements of intraarterial pressure (ABP), intracranial (ICP) and cerebral perfusion pressure (CPP
osuppressants, or others) from previously inaccessible terrestrial and marine natural environments.
eaction rate can be greatly reduced and tool life can be extended. In this Phase I project, Echemics aims to prove if the proposed technical
BCA method for use in pediatric populations that is safe, noninvasive, easy to perform, comfortable for subjects, relatively inexpensive, relia
tes from chronic wounds produced proteases in vitro that cleaved this target peptide. Also, over 90% of clinical samples taken directly from

ms with the DNAzymes identified in Aims 1-2. In Phase II of the project, the allosteric DNAzyme sensors will be tested in the field to determ
e, reduce the bacterial load, and aid in the resumption of healing. ECI has previously demonstrated that this compound, called heat gamma
oduction of this intriguing human anti-HIV protein. Edenspace's research partner, Dr. Mariam Sticklen at Michigan State University, has deve
tlines our efforts to demonstrate that the GroEL/osmolyte process can be streamlined to allow researchers to fold proteins from inclusion b
se the number of individuals with low literacy skills is substantial. Particularly, many students with high incidence disabilities struggle with v
 n predisposition to diseases and treatments and could thereby revolutionize medicine.
surement sensitivity at low frequencies, and increasing the upper operating frequency, which would represent a real advance in scientific m
g strength in science education, manufacturing and marketing. Specifically, we will rigorously assess whether the proposed products allow f
field technician. A single reader can be used for evaluation of hundreds of participants. The core concepts of this technology have bee
STTR effort will team Martin's group with EIC Laboratories to develop this new technology for proteomic microarrays. The 12 month Phase

elded accurate quantitative information about infarct size and distribution, agreed with the pathology gold standard, TTC-staining histoche
givers to review behaviors of interest. We will develop and evaluate an archiving system to permit educators and caregivers to record only
vities. The starting materials for this project are 15 large-insert clones showing antimicrobial activities against MRSA. These clones were disc

learning, group processing of social interaction, and effective communication with adolescents. The course will be developed for an online
e consequences and easily produce fine-grained analyses that meet local decision-making and reporting needs. Our Phase I activities focu
owns, users of AAC devices report that many persons are reluctant to spend time interacting with them. We will design a set of VG icons th
easibility and effectiveness of our novel technology. The specific aims are to: (1) design and optimize a single-channel optical device using M
n vivo efficacy evaluations in swine AVM models. This Phase I SBIR project will set the stage for developing a liquid embolic hydrogel for AV
erforming in vivo efficacy evaluations in canine aneurysm models. This Phase I SBIR project will set the stage for developing a liquid emboli
to 20nm for fully hydrated cell samples, and can produce 2-D and 3-D tomographic images. The ability to resolve sub cellular structures in

ertechnix using engineering and CFD modeling capabilities previously developed for other Government-funded projects. These component
oratory analysis has already been obtained on drinking water samples from New Mexico and remediation treatment process water from Ne

uit 180 museum visitors to view the prototype and complete a brief instrument assessing knowledge gain and their reaction to the exhibit.
methods to not only prevent not only HDN, but to target prevention of alloimmunization to blood group antigens in general. Importantly, t

oscillation, FO, such as IOS), or require complete interruption of airfow limiting data acquired to only one measurement every 3 breaths (R
germline competent ES cell lines in a non-murine species, improve the transgenic efficiency in rabbits, and make the production of gene tar
ency, selectivity and pharmacokinetic properties, then test the best compounds in a mouse model of arterial thrombosis, so as to provide p
two fields of interest. Trellis Bioscience is developing a technology that decreases the time and cost required to discover antibody therape
that use of this non-viral gene therapy system designed specifically for plasmid delivery directly to the brain tumor environment will safely
repeated application, nor do toxic effects appear. Also, a series of active C-terminal and N-terminal deletion constructs of lacritin were crea
cal samples. In Phase II, we will comprehensively assess these isoform expression patterns across numerous human breast cancer cell lines
le nitrocellulose assay membranes) to avoid the necessity for technology in-licensing. From a technical perspective we need to demonstrat
partner the vaccine with improved recombinant BCG vaccines and assess efficacy in additional strains of HLA transgenic mice.
city in a mouse model of hemophilia. A series of FVIII domain variants bearing single epitope modifications will be produced and their imm
es on the characterization of bioactive chiral compounds with the proposed system. A broad range of volatile chiral molecules will be tested
g oral consumption of alcohol (3-5 ounces). The appearance of DNA in EBC alludes to the possibility of a "self-identifying tag" to reliably an
s) at doses currently permitted by the FDA in exhaled breath after oral ingestion. Either the taggant or taggant metabolite(s) could qualify a
d from these studies will be beneficial to physicians in their efforts to asses a patients atherosclerotic plaque profile and possibly to predict

plication. The early diagnosis of cancer enables more effective therapy and enhances patient survival and quality of life. Fatty acid synthase
VE Industrial Metabolic Engineering Metabolic engineering will someday give scientists the ability to predicatively manipulate biological org
etabolic engineers to impart rational manipulations to the producing strain for improved production. These applications will have far-reach
third aim will require new versions of the probe that have improved sensitivity, precision, and stability. To increase sensitivity, new libraries
 to significantly dampen down the initial infammatory response and promote faster and effective progression through wound healing. We
biomedical research, where these tools will allow us to detect messenger RNA, RNAi, and other RNA molecules important in biology. Severa
development of handheld units that would be particularly useful for profiling exposure response in the field. In addition to saving time and

will record and transcribe all interactions for later analysis, and nurses and patients will be surveyed on their experiences with the system.
engineering in Phase II could ultimately lead to prostheses that perform better and for a longer period after implantation. The data and scie
fuorescein isothiocyanate- labeled jack bean lectin concanavalin A (FITC-con A) will be studied. We expect the developed methods and co
this grant, we developed a reliable bench-top single-cell microfuidic electroporation platform in a 96-well format. We demonstrated that t
ns of the SSP and the ESSP for Parents, and ongoing updating of content in the Best Practices databases. Audio capability of the surveys wil
e objectives for Phase I are to: Design and fabricate a miniature twin magnetic stop/electromagnetic valve with accompanying telemetry an
ne perturbation mechanism. Hence, the causal relationship between the perturbed gene and the HIV-1 resistant phenotype can be establi
nical areas in the need for low-input impedance (5 Ohms or less), nonmagnetic materials (to reduce image distortion), extremely low-noise
or the relative assessment of two pharmacologically distinct androgen receptors, each of which appear to mediate different effects on cell
of this grant application are to synthesize 200 mg of each compound and then test each in vitro (binding activity at human transporters for
infrastructure already in place to support the warfighter, with a natural transition path from the legacy PLGR and DAGR units.
er, GPS and ground marker to get the defection profile, (2) add the thermal scanner and ground penetration radar to the above for layer an

monstrate the thermal environment of the brake during the launch and recoil strokes, as well as assess the overall reliability of the braking s
d simulation for design validation and optimization of product performance at the earliest stage of the engineering process
y notification of possible damage to essential medical materiel; 7. require minimal human intervention; and 8. be capable of being integrat

on and investigations of the geology of Mars and the Moon. POTENTIAL NON-NASA COMMERCIAL APPLICATIONS ( Limit 1500 characters
ssion signatures. In Phase II, Eon Research will identify expression signatures for a wide range of important environmental contaminants us
use gas emissions.

l in excess of the 33 to 50% reduction necessary to deliver a one year capital payback as required by our commercialization partner. In this
e mixture&rsquo;s expression signatures. In Phase II, Eon Research will identify expression signatures for a wide range of important environ

ducing greenhouse gas emissions.

l in excess of the 33 to 50% reduction necessary to deliver a one year capital payback as required by our commercialization partner. In this
bilities to predict climate, weather, and air quality; and contribute to scientific assessments in support of environmental policy.
paration than currently available technology, leading to better reliability and reduced operating cost.

nt programs. To ensure program success, Anautics will work with NCMS in the OC-ALC Engines shop as a test bed for the IWCP application.
 PolyGeyser® bead filter to provide both nitrification and denitrification in aquaculture systems.
al threat agents (e.g., G- and V-series nerve agents, brucellosis, ricin).

r stocking.
displayed substantial resistance to calcification. The valve design will be optimized to address potential issues with calcification and blood c

with a compact permanent magnet. In Phase II, we will integrate the permanent magnet with compact electronics to create a prototype sm
those documents through end-user focus groups and subject-matter-expert (SME) reviews, and by producing a video covering a portion of

of being adjusted by the user while seated in the wheelchair. The innovative design of the Lightweight, Durable, and Adjustable Composite
xpected to make a significant impact on the complex, time-consuming, and expensive process of drug discovery. Graph-based representatio
nfidentiality-protected data prove scientifically useful and if the statistical disclosure risk can be controlled, then Phase II of the research wo
evelop beam forming and focusing capabilities in 3D and iv) Evaluate and test a 2D (48 element by 48 element) electrostrictive row/column
cle) accumulation are two major stress factors that can induce oxidative stress in retinal cells. Neuropotective candidate compounds identifi
mework for the commercialization of chemicals. The Specific Aims for Phase I of this project are to identify a group of known retinal toxican

valuate the merits of carrying out linkages of Medicare/Medicaid data for the Census surveys CPS, ACS, NHIS, and SIPP; (4) conduct a pilot
ot project demonstrating the effectiveness of the linkage approach created in Task 2; (4) work with CMS and our project survey partners?w
characterize the glyco-nanoparticles and verify the immunogenic activities of the glyconanoparticles. The success of the phase I project wi
develop a new tool for biologists to significantly increase the efficiency in glycan anaysis and meet the growing needs of glycomics researc

2. The end result is that children can achieve higher levels of gripping force with less physical exertion, freeing them to do what they desire
goal is to bring a new compound into clinical trials. Such a new compound has high therapeutic significance and would be of high commer
ent method of mechanical shaker agitation to dissociate pancreatic tissue is deleterious to optimum isolation results due to: 1) the need fo
itro with the eventual goal of finding new therapeutics against C. perfringens epsilon -toxin. Project Narrative: Epsilon toxin produced by Cl
ent and quantified the amelioration of some cognitive impairments following treatment with CPAP. Four neurocognitive factors were derive
undiagnosed OSA. Although many individuals do not routinely visit their primary care physicians, the majority receive routine biannual den
nded, parallel design clinical trial, and 2) demonstrating proof of concept of the ITD to prevent IDH in a randomized, blinded, crossover des
Pompe, Fabry, and Hurler diseases will be transitioned to droplet-based format. Demonstration of these enzymatic assays establishes the fe

le providing on- the-spot information when people desire assistance in decision making. Aware of this trend, health care providers are crea
PET to distinguish characteristics of brain function and anatomy that indicate future problems. The proposed miniature portable EEG reco
acute, life-threatening illness than the general population and will benefit from tools that minimize the likelihood of required transportatio

ocessed and characterized into a list of recognized poses and movement sequences that can be directly compared to a scripted protocol. A
ess network protocol, and performed simulations of the analog IC and wireless protocol. In phase II, AME, with its partners, will build a pro

at some point in their life. Radio- telemetry of EEG has been recognized as a goal in the epilepsy monitoring community for many years. Th
anti-GP88 therapeutic neutralizing monoclonal antibodies (Mabs). We have generated a large library of mouse monoclonal antibodies spec
eatment will increasingly take advantage of information obtained from tumor profiling assays, which will indicate customized therapies for
al performance measures for the multi-target immunoassay. Our initial clinical application will be early detection of lung cancer, although m

ropose to rigorously test the RCA frequency in c24 compared to 293 cells, and to adapt it to serum free growth. If the RCA generation can

psy for confirmation of diagnosis. In addition, no other local therapies are available for these patients. The primary objective for this Phase
understand the application of biomarkers to the diagnosis and monitoring of lung disease. There will be two elements to the clinic research
d two optimized designs for SBIR Continuation testing and pilot-scale production according to the FDA Draft Guidance for Industry (Metere
emether. Further, we anticipate that combining these steps will save on capital equipment and energy costs. The primary purpose of the pr
al. Thus this project proposes a method to significantly reduce drug discovery and early development risk by triaging public gene expression
EEG/EMG and noninvasive piezo sleep detection with uniquely designed disc-treadmills. This proposed Phase I project has three Specific A
homecage. These modules include the touchscreen for cognitive tasks, infrared (IR) matrices for positional and locomotor detections, and
and matrix components; 3) providing pro-survival signals to injected cells that will tend to increase their tissue survival and proliferation; a
m 2, we will synthesize a series of vancomycin:metal IFBM's. We will verify the stability of these candidate IFBM's in biological fuids, test th
etain exogenously delivered osteogenic factors such as recombinant proteins and progenitor cells. Secondly, we believe these peptide coati
mical release system for bound MSC's and verify their continued viability and multipotentiality after release. These studies, upon successful
allow for early intervention, before the individual falls and suffers from a potentially life-threatening injury. 3. Activity Assessment - the sys
 ectives of this Phase I application are 1) to determine an effective manner of loading commonly used barrier membranes with Perlecan do
ed, and new bone formation appeared to be enhanced by delivery of the Perlecan D1 expression construct in vivo. This Phase II project pro
n, and physical education. Additionally, these simulations could also be used in medical school training, patient education, and museums. O
nt. The crystal vibrates at its high resonance frequency when electric field is applied. However, the resonant frequency of the crystal decre
t novel speech processing techniques to improve the robustness of our automatic voice construction process while reducing the storage re

e conducted using established rodent models and procedures for evaluation of opioid pharmacology. These data are critical for discussions
Research Organizations (CROs), and the biopharmaceutical industry. It will increase the throughput and efficiency of clinical research, opera
hains of the hydrogel together until degradation occurs, thus slowing the rate of swelling. Specific Aim 2 is the characterization of delayed s
ttle Company of Mary Hospital. Specific Aims for the Phase 1 project are to: develop and implement a sample preparation and multiplexed i
eparation for 510K submission with Quidel Corporation. The performance goal at the end of Phase 2 is a sample-to-answer result in 2 hour
maintain pH, CO2 and O2 levels by our academic collaborator who will also test the system for long-term sterility in mock MEA cultures and
using the RMD Geiger mode Avalanche Photodiode array detector. The key challenges in the Phase I program will be to build the prototyp
ns of TBI biomarkers in model samples. In Phase II, we will optimize the design of the microfuidic system, develop software to run on a "pa
large area, high resolution detectors needed for important time-resolved X-ray diffraction and other studies. The goal of the proposed Pha
or less) are required for nearly 100% absorption of thermal neutrons. This is important for three reasons. First, it improves utilization of the
east cancer cells. It will be localized within tumor and its luminescence intensity and lifetime will be oxygen- sensitive. Because poor oxyge
etail stores and parents, to examine goods for lead content.Narrative Lead and its compounds pose a great threat to human health, especia
stablished for alumina is adaptable to LSO as well. We will establish techniques to fabricate the necessary nanoparticulate powders and to

hundred million dollars. A significant fraction of this market represents areas where the involved technologies will have a major impact.

help to advance basic research in protein mechanisms as well as drug design. Non-biomedical applications could be found in non-destructi
vy analysis by exploring soft clustering approaches, structured classification and effective user interface design. We have partnered with Ha

of the technology needed for a substantial business opportunity to license the technology and manufacture ELISA kits for quantitation of an
st alcoholic neural and behavioral pathologies by determining (1) if transdermal delivery of cannabidiol can prevent alcohol-induced neurod
del of central venous catheter infection in rats. Commercial applications include catheters, medical, optical and dental devices.
n increasing number of positive clinical reports that show sonography can distinguish benign from malignant solid nodules with, it is likely t
alpha emitter 212 Bi, 2) examine the in vitro subcellular distribution and cytotoxicity of 212 Pb-labeled DOTA-NT-MSH and a control DOTA-
grant, curie quantities of Ra-223 and Th-228/Pb-212 will be available at purity levels required for medical research. -Relevance This Phase I
generate binding concentration-response curves. The results of this investigation will establish the feasibility of incorporating glycan microa
seases in association with Dr. Peter Merkel, Director of the Vasculitis Research Consortium. Proteome-wide screening against sera from p
y to routinely detect and characterize drug- resistance mutations in the PR and RT genes down to the 5% level. Dr. Richard D'Aquila's labora
e also achieved including: i) Ability to scan missense mutations using the K-Ras gene as a model from cell-line, tumor and stool DNA; ii) Enh
ditionally scan for missense mutations by precisely measuring the mass shift from single amino acid substitutions. Studies performed using
the extraction and detection of miRNA from two different clinical sample matrices, both of which are accessible from the current PrCa pati
options. The availability of this assay for leukemia and MPD mutations should greatly improve the clinical decisions necessary for effective

cific Aim 1. Develop a novel class of detergents ("birosh" detergents) that will self-assemble with more traditional detergents in aqueous s
ections, those acquired after admission, will be reduced because the link between one patient's infection and another's, via health care wo

y around Ang 1170 comprising 21 compounds with potential SF/HGF-like activity. The goal of this Phase I application is to couple targeted
to in vivo bioefficacy studies in order to identify a lead SF/HGF mimetic within each chemical class, with the eventual goal of bringing an SF
n solutions. Preliminary data indicate that Refanalin protects against apoptotic/necrotic cell death in vitro and preserves organ function in
e improved by modifying substituents on its 2,4-diaminoquinazoline scaffold. In particular, ANG 1490, a newly prepared ANG 797 analog wi
identified a small molecule compound, termed Ang1170 that showed antifibrotic effects both in vitro and in vivo. Our preliminary data ind
ctor (HGF/SF). Moreover, Ang797 also inhibits activity of a second RTK associated with angiogenesis, Tie-2. In vitro, Ang797 inhibits endoth
with significant clinical potential. In vitro, Refanalin activates the same intracellular signaling cascades as HGF/SF, scatters renal cells, induce

urium A1 is a double amino acid auxotroph that requires Leu and Arg. We have now demonstrated that human prostate and breast tumor

eins may be produced from a UBL-type expression system and solid matrix UBL protease fill a great need in industry and could also address
iversity will serve as clinical test sites. Age-related macular degeneration (AMD) is the leading cause of blindness for individuals in develop
ening candidate PG structures in a keratinocyte cell culture system to identify a PG analog that maximizes anti-proliferative potency, adapti
ug in mice, and evaluation of the efficacy of the formulation in reducing prostate tumor in mouse xenograft models. The data generated fro
gnosed and treated, with lower cost and with increased convenience. Many children snore when they sleep. This can be a sign of difficulty m
f-of-principle demonstration that SK inhibitors are likely to be effective in the treatment of eye disease. In this Phase II project, we will evalu
tinylated membrane with chimeric proteins. Preliminary data have demonstrated that the display of FasL on pancreatic islets (ApoFasL the
hibitory immune evasion mechanisms may contribute to this effect. To overcome some of these difficulties, a novel technology designated
nts will be the first step along the critical path for the development of ApoVax104 as the second-generation platform technology for ApoIm
he potential of revolutionizing the clinical opportunity for siRNA. Our primary focus is on the cancer drug market, a $36.9B in 2004.
ppalachian Electronic Instruments (Fairlea, WV). Specific Aim II: A user friendly instrument control interface and optimized Detect- X(tm) so
e modules will be made available as software over the World Wide Web. 4.) Evaluate the effectiveness of the course - A 2-tiered approach o
the simulation will be evaluated based on the time to detect a given event, formulate a correct diagnosis, and provide effective supportive
id wakeup by the patient while maintaining adequate analgesia during recovery. If successfully implemented, use of the PkPd Display could

with Dr.s Charles Apperson (NCSU) and Eric Wan (OHSU-OGI), we will instrument conventional mosquito trapping systems with the second g
tic signatures. Because many contaminants act at the gene level to induce or repress gene expression through both receptor-mediated and
have proven anti-tumor activity agains lung cancer. The overall objective of the Phase I project is to demonstrate the feasibility of develop

s, are contamination-free, maintain their concentration levels, and are correctly and positively identified. When completed, the system wil
ar, cellular, and clinical aspects of drug action mechanisms, metabolism, and toxicity. The knowledge base will be populated (and automatic
further preclinical development of alginate-based immunotherapeutics by preparing and testing the protective activities of a human mAb
horse, which will allow the production of the corresponding fusion protein, AGT-180. The fusion gene will be incorporated in a eukaryotic

ce with regulatory requirements. Colonoscopy Force Monitor (CFM) is a handheld device measuring and displaying the torque and push/p
omings of several current technologies. Hematopoietic stem cells have been shown to rescue abnormal retinal vascularization in a murine

anufacture a new needle holder for the robot and develop the software to command the robot from small animal MRI images for precision
mia is a potentially life-threatening condition where blood glucose concentrations drop below normal values. Episodes of severe hypoglycem
data generated will guide the design of the commercial biosensor device. The end user of such a device will be the field personnel likely to
ost-transplantation with safety component in both male and female neonatal rats, using optimized conditions from Aim 1 (as per FDA reco
e will precipitate at the injection site because of its poor aqueous solubility when the water-miscible solvent/vehicle in the buprenorphine

ate targeted sequences across nine DNA samples. The proposed technique is somewhat simpler than MARA and should be even more spe
creases comfort. In addition to meeting these goals, the earphone must have a frequency response that is similar to other audiometric ear
alterations to the structure of a cyclic peptide, this is rarely done. The reason for this is that the complexity and chemical properties of mos
costeroids have the potential to treat several diseases, we are developing a sustained release inner ear delivery system for this class of dru
ase characteristics of these formulations; and to test the in vivo pharmacokinetics and the local safety of the formulations in animals. The d
val of novel drug delivery systems. This project could lead rapidly to the development of an improved injectable dosage form of apomorphi
tive for treating pulmonary fibrosis by inhalation and intravenous routes. Preliminary studies indicate that a high-molecular-weight TGF-a p
an innovative radiopharmaceutical product for the evaluation and diagnosis of AD. A widely available SPECT imaging test for AD will yield s
ortunity for diagnostic imaging of diabetic and pre-diabetic patients. Vesicular monoamine transporter (VMAT-2) is expressed in beta cells
asibility of processing long multi-fasciculated nerves will be evaluated by applying a proprietary multistep allograft preparation method (alr
stration. Here we will test efficacy and measure dose-response using intravenous (IV), oral, or a combination of IV/oral administration. Our
results and recommend one of the following decisions: Go: proceed to the next stage; Redirect: based on incomplete deliverables, changed
ypothesis that both biomarkers are increased in CSF and serum of human patients with severe TBI was generated and preliminary data sho
rally recommended values. Additionally, the "usability" (as contrasted with "functionality") of the new FIP assessment method will be asse
tus and subsequently of the young infant, has strong clinical significance as an indicator of brain function and dysfunction. Presently, asses
declared pain the 5th vital sign. Products resulting from this research are anticipated to offer a great benefit to the field of pain assessmen

valuate the biological indicator prototype by comparing it with conventional biological indicators using spore outgrowth as a para

n large-scale tasks in bio-sequence annotation. Key innovations in this phase will be the integration of FPGA logic with the mass storage sys
that the CDCU program is effective in reducing heavy drinking, it could be widely disseminated at relatively low cost. Our pricing structure
mparing OA and SMART Recovery group involvement to SMART Recovery group involvement alone. Developing a web application for SMAR
h the use of internal consistency, split-half and test-retest procedures; 5) Using survey data from a national sample of Hispanic adolescents,
ning materials that will facilitate the utilization of such approaches by practicing clinicians. Behavioral activation (BA) is an evidence-based p
empirically-based treatments do exist for children and adolescents diagnosed with panic disorder, only a relatively small percentage of this
used to treat neurological disorders such as schizophrenia, depression, and Parkinson's disease. To accelerate discovery of more selective t
The migration of cells from the bloodstream to sites of injury is one of the fundamental processes underlying chronic infammatory disorde
ptosis, and invasion using mammary epithelial and stromal cell lines as well as primary cells. In situ immunocytochemistry methods and fu
o cell assays. This phase I proposal will establish an HuES cell based pancreatic progenitor assay for the purpose of screening for biological m
he disease are limited. Bexion Pharmaceuticals, Inc. is developing a first-in-class cancer biotherapeutics that has the potential for the treatm

target trajectories across the range-of-motion in both VSC and VLC phases of each training repetition. Trainees modulate their level of exer
ed dosing, and physiological data acquisition modules for core body temperature, blood pressure and electrocardiography. In accordance w

ate range, chemo-selectivity (particularly a,a-unsaturated carbonyl compounds), and stereoselectivity of each enzyme will be carried out. T
we will refine the design of the hand-held BFI to make it more versatile and reliable for human use my making it lighter, wireless and compa
unprecedented fexibility in accessing the breast tissue in vivo. A successful outcome of this Phase I project will be a full functional prototy
c practices in two representative bioscience laboratories using the tool created in Specific Aim 1. Phase I, Specific Aim 2b will evaluate curre
ese mutations. We propose to develop assays for the key EGFR mutations infuencing response to TKI. The assays we propose to develo
complete replisome and thus may yield a more uniform amplification on entire genomes when limited numbers of initial copies are presen
development of improved technology and new, lower cost devices for the purification and isolation of biological samples. Potential applica
n of the technology that we are proposing to develop. A second goal is to expand the capabilities of the Biolog Microbial Identification Syst
eld PDA. The next steps in commercialization of this device are to complete the miniaturization and integration with the PDA, complete the
ose to demonstrate, in a non-heparinized hybrid model of controlled-uncontrolled hemorrhagic shock resuscitation in the rat, an accepted
models: a) that the upregulation of P-selectin enhances the adhesive, physical, and coagulation properties of HAF, and to determine the ext
of uncertainty in the exposure estimates using validation metrics; and (c) Developing and testing a user-friendly interactive software protot
: TerraSeer Space-Time Intelligence System(tm) (STIS(tm)). geographical and racial disparities. The substantial benefit of this research is its
Residential Histories Relevance: The techniques and software to be developed in this project will provide a more concise and accurate desc
ful portion of Phase I. These sequential methods include design input, product development, product integration (MEMS sensor, ASIC & bi

gens which can be recombinantly-expressed in bacteria and then create an expression vector to allow the rapid cloning and expression of p
eptide to develop new, more sensitive immunodiagnostic assays. In a subsequent Phase II proposal we plan to screen and optimize a comb
, NY. In a subsequent Phase II SBIR proposal, we would expand our field studies to span the two-year life cycle of the tick vector and assess
ly available analytical technology and will utilize clinically available compounds. Therefore, this test will be able to quickly enter the market

s required for IND filing with the FDA and will perform efficacy studies to evaluate our MRA reagent using an in vivo swine model of myocar
he presence of excess level of DcR3 in the serum. The assay will be also validated in accordance with the FDA regulatory guidelines so that
ase the success rate of therapy thus reducing the burden of medical care costs, as well as enhancing the quality of the patients' life.
sity, has marketed state-of-the- art retinal FDOCT systems operating at 830nm wavelength using both conventional and handheld delivery o
or accuracy, detection threshold and usability for infant HIV diagnosis and adult HIV viral load quantification. As with existing gold standard
coli, encodes the biosynthetic pathway for the hydroxylation and glycosylation of 6-dEB. The ability to rapidly engineer bacterial chromoso
oreduction mechanism, including reporter gene assays to study cell signaling pathways and immunological detection of proteins such as w
so wideband (field and action potentials) brain signals can be recorded using depth electrodes implanted in the brains of awake freely-beh
ods of intact speech, provided that they contain at least one sample of each phoneme. In Phase I, we will develop and evaluate a VT based
lace the stool on the card after rectal examination) and mail them to our central laboratory for bacterial fingerprinting. The goal is to identi

isparities. Based on the successful completion of a Phase I project testing the feasibility of a radio formatted Entertainment-Education strat
eted products with FDA approval. SUPRAER(tm) will decrease the time required for inhalation therapy as well as broaden the range of ther
The anticipated result of this study will be a rapid, first response system capable of high-throughput microbial community analysis of a varie
ying/vacuum-packaging. III. BioTex chemists in collaboration with commercial facilities will perform studies to optimize conditions of radiati
multi- color cell permeable and sensitive caspase substrates described in this project will allows studying caspase-3 activation in live cells a
that will provide parameters that can be used to more efficiently and successfully provide useable whole-cell recording configuration. It is i
and build the device hardware from off-the-shelf components with the help of Bolton Engineering. Low vision experts Drs. Don Fletcher, M
mal bone registration parameters. Specific Aim 4: Show the feasibility and benefits of TSA planning/navigation for glenoid placement by com

s. During Phase I we identified sites in sFlt-1 that can be modified without affecting the protein's in vitro bioactivity. We also performed a p
ers and clinicians have been unable to see critical features in the human retina due to ocular aberrations that limited imaging resolution. A
PE), is the second leading cause of sudden, unexpected death in the U.S. Physicians lack a quick, accurate method to diagnose and exclude
MNC) based on gas-phase deposition of a silver salt-containing polymer that effectively inhibits biofilm formation for a wide range of microo
MPs will be optimized for stronger killing ability, higher binding affinity, smaller size and suitable stability in saliva; 2) Extensive cellular toxici

proteins do not have a readily measurable reaction product (as is the case for protein kinases), so these proteins remain very difficult to tes

cal governments relating to: airborne emissions, waterborne effluents, external radiation levels, outdoor noise, solid and bulk waste dispos
ompounds that block or reverse the toxic effects of protein aggregates employing an established high-throughput cell protection screen ba
on at micromolar or lower concentrations, shows DJ-1 selectivity (ideally at a ratio of DJ-1/other tested targets >3), is toxic ideally only at co

ercialization plan would include the formulation and initiation of appropriate clinical studies leading to the introduction of a Human Hydrati

ssess the human CPCs' differentiation into cardiac muscle in situ, following ischemia- reperfusion injury in immunosuppressed pigs. Th
 etics and distribution in a mouse model, and efficacy against a lymphoma model. The early portions (specific aims 1 and 2) of the project in
s of our commercial cerebral oximeter. If successful, we will commercialize the first FDA approved absolute cerebral oximeter, since comm
bility, utility, and commercial potential of the two prototype BASICS DVDs among college student health professionals (n=40). The proposed
apeutic effects. Based on these combined lines of evidence and our recent study, we hypothesize that multiple low dose injections of U-CO
rm dithizone positive islet-like structures. Successful demonstration of feasibility in these Phase I SBIR studies will consist of technology tra

n a prototype CryoInjectTM System; SA4 - Test the efficacy of the CryoPellet(tm) and CryoInjectTM System during cryosurgery. Successful co
used to protect nerve cells from the destructive mechanisms of freezing; SA4 Test the efficacy of NeuprosolTM as a nerve-sparing concep
ated-lysine sites in an easy-to-use web-based format, as we have done for phosphorylation sites in PhosphoSite(r). This project has the pot

We are improving PhosphoSite(r) so that it can accommodate the vastly increased number of phosphate modifications now being discove

delineate the processes which underlie deregulated proliferation in cancer cells, and to apply this technology to identify cytotoxic peptides
roliferation in cancer cells, and to apply this knowledge into translational research programs. For example, we will use our newly developed
e FV shRNA databases will be used to develop and release as a commercial product FV shRNA libraries cloned into lentiviral vectors. Geneti
against death following higher doses of irradiation. Medical application of radiation as a therapy for malignancies or as a preparative regime

her technologies. The proposed studies are aimed to critically evaluate this reagent and to develop a protocol for simplified sample prepar
o isolate hESCs and remains a leader in hESC research. HEK cell hERG screening was first developed in the lab of Dr. Craig January and is cu
consumers as well as improving the efficacy of patient care by reducing human errors and catching dangerous counterfeit medicines at the
s are of great benefit to the point-of-care market, since they can be leveraged in a variety of assay systems to create highly sensitive, multip

d upon non-carbohydrate polyether C9-modifications within second generation macrolides (roxithromycin) with notable antibacterial prope
ns in the attached sugars using old and new leads. Secondary assays will involve (i) cell-based tests of potential cardiotoxicity due to long Q
d organ preservation solutions (KPS1 and UW Viaspan) for 24h preservation of fresh porcine pancreata. The safety and efficacy of this new t
ell differential count using computer imaging.
to contamination and to enhance the versatility of this assay for commercial use. Development of a robotic screening assay for anti-EA is c
ities than CA4 and SU5416. We hypothesize that the novel CA4 analogs have therapeutic potential in the treatment of retinal NV. Our obje
tes, with 2.7 million new cases in the U.S. each year. All people with diabetes, both type 1 and type 2, are at risk to develop DR. Diabetic re
ent DR models. The results showed that Compound 4 has significantly more potent effects on reducing retinal vascular leakage when comp
estigators have developed unique leptospiral antigens that will be used in the proposed work. The two specific aims of the Phase I studies w
using a simple amperometric device similar to a glucometer. This new sensor will avoid the need for expensive nucleic acid labeling and o
is being investigated as a potential target for new pharmacotherapies to treat the disorder. New medications based on small-molecule inh
major environmental threats worldwide as millions of human beings have been exposed to excessive As through contaminated drinking w
roject aims to make a clinical test that would predict very early whether a pregnant women is at high risk to deliver prematurely. Early risk
ur commercialization plan, and whose clinical efficacy can be assessed in a formal Phase II assessment of TEACH to quantify its value to bot

easure hundreds of analytes simultaneously in near-real time in minute sample volumes (~5 - 50 fL). The long-term goal (at the end of Phas
ty to visually detect antigen-specific CD4+ and CD8+ autoreactive T cells binding to MHC-peptide-complexes and to correlate MHC: T cell re

e modules and a clinical base station. A motor module will sense three-dimensional motion. A physiologic module will capture standard ele
cology are fawed. We propose to: 1) To compare the permeability values of clinically relevant antiepileptic drugs in vivo versus in vitro. Th
th caregivers to evaluate the website design and content, and developed the assessment instruments to be used in Phase II. In Phase II we
 of use and effectiveness of content in changing knowledge, and for marketing the 6-module sequence to Emergency Medicine Physicians
pounds for the treatment of psychosis and cognitive dysfunction associated with schizophrenia. Cognitive deficits, including impaired mem
brillar plaque amyloid. The aim of the present proposal is to test the efficacy of a potent anti-infammatory compound, COG133, which is a
th infammation of the intestines, abdominal pain, cramping and diarrhea. These symptoms vary in severity, but are often debilitating for p
ammatory/neuroprotective peptide, COG133, that may be an effective therapeutic for neurodegenerative disease. In this proposal, we wil
f systemic infammatory cytokine levels (serum TNFa, Il-1?, IL-6 levels), clotting times and activation of cell signaling (phospho-JNK, phosph
igodendrocyte Precursor Cell) proliferation and differentiation/maturation within the corpus callosum in a cuprizone model; 3) Specific Aim
llowing aspects: 1) if COG compounds can shift Th1 response to Th2 in EAE model; 2) how COG compounds affect the function of antigen-p
stablished performance requirements. 2) Optimize the physical characteristics of cured bone adhesive. The candidate formulations develo
hed performance requirements. 2) Develop delivery device prototypes to spray adhesive evenly onto planar surfaces. A spray tip will be de
an skin DCs in vivo. If our efforts are successful, the product will be an inexpensive small molecule, applied to the skin over a vaccine injecti
backgrounds. If the novel task using carrier sentences is found feasible, materials with more variation in carrier sentences, speakers, and ta

eutical solvents and also evaluating membranes in the vapor separation mode. Additional upgrades will include modeling and system desig

ce. There are three specific aims in this phase 1 proposal: 1. To design and synthesize a series of novel puerarin derivatives. 2. To evaluate p

available CI processors and will utilize novel digital signal processing techniques to create the test signals. The proposed instrument will hav
methods. This makes them heavy, bulky and excessively power consuming. On the other hand, pulsed introduction reduces the gas load and
native, the Pain Self- Management Program (PSMP), a web-based psychoeducational self-help system for adults with chronic pain. The prog
erall Phase I and II endeavor by demonstrating efficient mPBE calculations for generally-shaped biomolecules using carefully tailored compu
d piece and perform ex vivo and in vivo experiments on a lapine model. Surgical endpoints will include the quality of the wound seal, the e

to withstand a range of external mechanical forces. We will install and test a Mini Mill Vertical Machining Center for precision manufacturin

hange, and practical. Relevance to Public Health: Improved instruments are critical for use in and for use in public health research where o
from a wheelchair into and out of a bathtub determined. Feasibility requires both stakeholder and engineering support for one or both stab
ncorporate user feedback. Phase 2 will expand the functionality and conditions covered by the system in order to explore different paths to
rake Rehabilitation Center (Cincinnati, OH) under the direction of Stephen Page, PhD. The feasibility study will include recruitment of three

m a preliminary investigation of critical engineering, clinical, and regulatory issues that will contribute to the success of a Phase II. One are

ar-term market potential for biopharmaceutical cell line development as both a commercial fee-for- service and product application on LEA

integrate with bone. The two primary novelties of this work are: (i) accelerated generation of mechanically functional cartilage within a br
oal of these investigations is to find new drugs that will improve cancer treatment by helping the body to kill its own tumor. While this proj
erience are in place to develop novel non-narcotic pain agents. Phase II studies will focus on larger animal models, sites of action as well as
ly, we will evaluate the number and function of adipose tissue-derived cells with vascular potential obtained from persons with risk factors
pplied, even without benefit of deuteration. Furthermore, proteins that tend to aggregate or even form insoluble precipitates have been su
roject period, we will conduct formative research with professionals, advocates, parents, and young adults with AS/HFA. We will also write
ased on concepts adapted from effective use in other disciplines/environments and making use of today's technology, to enhance relapse-p
tients. In Phase I, we will establish an advisory group; conduct a literature review; develop the guides, posters, and brochures; conduct foc
lly Ill and focus groups with clinical and family stakeholders to guide product development; (2) develop the content for one module of the

an Advisory Panel content review and feasibility study with professional stakeholders. In Phase II, we aim to incorporate recommended ch
 The software will be useful to biomedical researchers working on sociological, behavioral and biomedical studies with complex data structu

control, career prospects) that can impact the quality of their life. This Phase I application proposes to test the feasibility of producing an in
h Borderline Personality Disorder series, in family members' level of knowledge regarding BPD, their sense of empowerment, their level of
M. Once these components are developed, we will conduct a full-scale outcome evaluation with students and teachers to determine the e

ns of existing workers, facilitating recruitment of new workers, and reducing worker attrition. Better training for coping with sleep behavior
chniques will be developed and employed. These demographic updates will offer a valuable addition to the existing AllocateChina system.
MIS. Methods for soft tissue debridement will be developed by completely redesigning the currently available instrumentation (D'granulator
(1) wide availability independent of physical location of trainees; (2) a standardized curriculum for use by multiple sites within Greek and u
totype. The formative evaluation will utilize a non- experimental two-panel pre/post design with 20 oral health professionals. In Phase II, w
d some 'endemic markets', there is an increasing ability to pay for drugs in countries such as India and China and the military and traveler m
her assistance. It could also provide insight into the spatial aspects of disparities in health status, health conditions, and access to care. Any
o demonstrate the principle that tests used in developing countries should be of the same high quality as those used in developed countrie
pecific diabetes protein antigens, for which there are commercially available immunoassays. The success of this Phase I study will lead to a
he format of column chromatography will be used in place of the batch selection protocols currently used for phage display selections. Pha
an be expanded to motivate adherence to other chronic diseases.
ing a simple and elegant way to monitor depression through voice analysis. The SPIMA index will become an important longitudinal measu
m to detect novel allosteric regulators of protein kinases which could provide the pharmaceutical industry with an approach to develop a ne
oping EFC to measure activation of different subfamilies of growth factor receptors. These studies will provide the foundation of future pha
e efficiency of a LTT targeting tether to enhance uptake and transposition of a pKLAT2 transposon vector into liver cells in mice.
re two Specific Aims: Aim 1. Evaluate Sleeping Beauty transposon-mediated integration and long-term expression of the FANC-C gene in he

ut a burden on management. Finally, a six-month field trial of the new safety cap-mounted communication-capable hardware will be perfo
ofilaricidal effects. In the current research, two well-characterized and essential enzymes from a filarial nematode biosynthetic pathway wil
we plan to complete development of a modular, "industrial" version of the liquid lens array-microscope instrument including 120 miniature
with appropriate GUI. 3) Integrate ThermoBLAST into the automated sequence design algorithms of Visual OMP. ThermoBLAST will be integ
igh energy radiation. This research and development effort will result in a device that will provide therapists with a visual check that the pl
d coil design will reduce sample losses, minimize SAR, and improve S/N significantly. The coil design will be based on full-wave, finite elem
te the feasibility of the approach using a combination of NMR experiments at 500 MHz and work-bench experiments at 900 MHz. The Phas

develop will help Dentists detect hairline cracks and other high-resolution features while patients will benefit from a reduced lifetime x-ray
apability of the detector system, a critical characteristic due to the large x-ray fux incident on x-ray CT detectors. We will choose an optima

cerebral perfusion pressure (CPP=ABP-ICP) and BFV in 30 patients with traumatic brain injury, using existing databases from the Syncope an

prove if the proposed technical approach can indeed extend diamond tool life compared with normal diamond machining. If Phase I is suc
jects, relatively inexpensive, reliable, and accurate. With that in mind, Echo Medical Systems is proposing the use of a QMR-based (Quantit
nical samples taken directly from infected wounds were shown to have significant protease activity toward the target peptide. This work als

ill be tested in the field to determine their absolute and relative efficacies as toxin detectors. This includes integration of the DNAzyme sen
s compound, called heat gamma (HG), is an effective inhibitor of proteases produced by P. gingivalis and host matrix metalloproteases in vi
chigan State University, has developed a plant-specific construct containing the gene for SLPI, with a polyhistidine tag for purification. This
to fold proteins from inclusion bodies in a single pot reaction. An important milestone in these studies will be the demonstration that the
dence disabilities struggle with various aspects of reading and literacy-related skills. A large number of these students will either drop-out
 ent a real advance in scientific measurement capability. The overall aim of this Phase I SBIR program is to establish the specific embodimen
er the proposed products allow for increased science interest and achievement of National Science Education Standards. As science and tec
epts of this technology have been developed and demonstrated. Literature results show SERS detection of organochlorine pesticides and E
microarrays. The 12 month Phase I study is designed to demonstrate the feasibility of the approach by establishing membrane production m

d standard, TTC-staining histochemistry, and was superior to DE. While the primary aim of the Phase II project will be the development and
rs and caregivers to record only those behaviors judged to be important for later retrieval and review. The "experience buffers" described p
nst MRSA. These clones were discovered during a project funded by an NIH/NIAID Small Business Biodefense Program Phase I STTR grant. A

e will be developed for an online format that EMT is developing to meet the learning needs and resource constraints of line prevention staff
eeds. Our Phase I activities focus on four aims: 1) develop a product plan and specification document for the proposed Substance Abuse C
e will design a set of VG icons that give device users control of tailoring their own voices to their intentions. Based on recommendations of
e-channel optical device using Monte Carlo simulations; (2) build an alpha prototype device based on the simulations, and (3) validate the
a liquid embolic hydrogel for AVM treatment.
ge for developing a liquid embolic agent which is easier to use and the therapeutic outcome of treating an aneurysm can be improved by sh
esolve sub cellular structures in hydrated cells, and to create those images in minutes rather than days, could lead to more rapid advances

ded projects. These components will be tested using an existing, fully instrumented aerosol chamber and a variety of standard diagnostic m
treatment process water from Nevada. These results provide high confidence that the proposed analytical methodology will be an effective

and their reaction to the exhibit. Some visitors will also be asked to participate in focus groups in which they can share their reactions in a d
ntigens in general. Importantly, this project will provide a unique and accurate model system with the potential to study a broad range of cl

measurement every 3 breaths (Rint). Three major advantages of APD include a requirement for natural breathing only, relatively less effect
make the production of gene targeted rabbits possible. The rabbit is a good animal model for the study of many human diseases beca
ial thrombosis, so as to provide proof-of-concept that selective inhibition of PK could provide a novel therapeutic approach for reducing ris
ed to discover antibody therapeutics, which now represent the fastest growing segment of the pharmaceutical industry. Drugs in this class
in tumor environment will safely produce high local levels of IL-12, a potent cell mediated anti-tumor effect and lead to an efficacious thera
n constructs of lacritin were created, which may be more suitable for drug development. They will be tested in Phase II. Long-term goals of
us human breast cancer cell lines and human cancer tissue samples. We would then like to expand our measurement capability to protein i
spective we need to demonstrate that our "avidity" anti-CD4+ capture reagent displays a dissociation constant for CD4+ expressing T cells a
A transgenic mice.
will be produced and their immunogenicity will be evaluated. The focus of a Phase II SBIR will be studies of FVIII constructs bearing multip
le chiral molecules will be tested as chiral modifier for the CIMS. The research seeks to explore optimal instrumental conditions where max
self-identifying tag" to reliably and accurately link an EBC sample to an individual subject source. The goal of this proposal is to expand thes
ant metabolite(s) could qualify as an EDIM. Specific Aim 2: Test whether the GRAS taggant candidates identified in Specific Aim 1 are suitab
ue profile and possibly to predict and prevent sudden MI induced by plaque disruption. To achieve our overall goal we propose the foll

quality of life. Fatty acid synthase is present at high levels in most common human cancers including colon, lung, prostate and breast cance
atively manipulate biological organisms for many useful purposes ranging from strain improvement and other industrial biotech application
e applications will have far-reaching effects in disciplines such as pharmaceutical production, agriculture, and many other biotechnology ap
ncrease sensitivity, new libraries of fuorescently labeled FABP mutants that do not bind fatty acids will be generated by combinatorial muta
 ion through wound healing. We hypothesize that ACT1 peptide will provide a unique, mechanistically based approach to restoring normal
ules important in biology. Several important diagnostics and drug development tools been driven in the past decade through the creation
d. In addition to saving time and offering greater convenience these multiplex sensors will allow far more molecular data to be collected tha

ir experiences with the system. (5) At this point, Sehda will isolate the conversation segments and code them for accuracy to objectively as
r implantation. The data and scientific knowledge gained during the Phase I effort also has potential applications in real-time medical diagn
t the developed methods and commercial tools to be valuable to biologists, chemists, and pharmaceutical scientists, especially for dug, dia
format. We demonstrated that this system could be used to permeate the cell membranes of an array of suspension cells in a controllable
udio capability of the surveys will enhance their accessibility to respondents with limited reading proficiency. Advanced website features inc
with accompanying telemetry and data acquisition system. Perform short and long-term in vitro tests of the valve to demonstrate detection
sistant phenotype can be established as the phenotype reverses with the reversal of the gene perturbation. In Phase II, functional validatio
distortion), extremely low-noise figures, and robustness in the 64-300 MHz frequency range. In Future Instruments' mission to develop pre
mediate different effects on cell survival. One receptor (the classical, intracellular/nuclear androgen receptor), subserves a beneficial (cell s
tivity at human transporters for norepinephrine, serotonin, and dopamine expressed in cell lines; inhibitory activity at a human cardiac ion
GR and DAGR units.
n radar to the above for layer analysis, (3) add a portable falling weight defectometer to the system (1) for test verification at discrete poin

overall reliability of the braking system over multiple launches that are, and are not, within the given maximum end speed scenarios. AMT
ineering process
d 8. be capable of being integrated into the Defense Medical Logistics system(s).

CATIONS ( Limit 1500 characters, approximately 150 words) Currently no non-NASA applications are envisioned since terrestrial commerci
environmental contaminants using sequence-defined oligo microarrays. By the end of Phase II, Eon Research will have commercially availa

mmercialization partner. In this Phase II proposal, we will develop this modified membrane, verify its functional performance in a finalized
wide range of important environmental contaminants using sequence-defined oligo microarrays. By the end of Phase II, Eon Research will h

mmercialization partner. In this Phase II proposal, we will develop this modified membrane, verify its functional performance in a finalized
nvironmental policy.

st bed for the IWCP application. This will ensure no production DOD systems or networks are impacted during the test and development e
ues with calcification and blood compatibility. A novel dynamic in vitro calcification model and an in vitro blood compatibility model will als

ectronics to create a prototype small animal imaging system.

ng a video covering a portion of the content and conducting a field trial of that video. Phase 2 will develop two interactive courses, a web p

able, and Adjustable Composite Backrest will provide necessary postural support and provide the user a variety of self adjustable positions
overy. Graph-based representation of chemical compounds results in a more accurate realization of the chemical space. The use of recent t
then Phase II of the research would synthesize the entire HRS/SSA data link. The project scientists will work with the HRS Data Release Pro
ent) electrostrictive row/column array prototype. Based upon the successful completion of the Phase One aims, the proposed Phase Two w
ve candidate compounds identified will be developed for the treatment of the dry form of AMD. Specifically, Phase I of this SBIR project co
a group of known retinal toxicants, to prove the feasibility of ranking their (photo)toxic potential, and finally to show these rankings correla

HIS, and SIPP; (4) conduct a pilot project assessing the effectiveness of the Census-compatible linking methodologies using Medicare and/or
nd our project survey partners?which include HRS, PSID and NLTCS?to establish protocols that maintain data privacy, recognizing that each
success of the phase I project will provide the scientific and biomedical research communities with a set of kits for conjugating biologically
wing needs of glycomics research and biomedical applications.

ing them to do what they desire most-play. This Phase II effort will focus on refining the proven Phase I prototype design to 1) minimize its
ce and would be of high commercial and social value, with additional potential utility towards other addictive substances such as alcohol, a
on results due to: 1) the need for a heat exchanger that results in a large thermal latency which exposes the cells to continued harmful enz
ve: Epsilon toxin produced by Clostridium perfringens is one of the most lethal bacterial toxins. It is regarded as a potential biological weap
urocognitive factors were derived from the AMP data: sustained attention, processing speed, verbal memory and visuospatial memory. Pr
rity receive routine biannual dental examinations. Dental professionals can therefore play an important role in the identification of patients
domized, blinded, crossover design clinical trial. A successful clinical trial result will provide proof of concept for use of this new non-invasiv
zymatic assays establishes the feasibility of a digital microfuidic chip for newborn screening.Advanced Liquid Logic, Inc. is developing a lab

d, health care providers are creating "mobile editions" of their web sites and Internet-based tools. These editions, while similar to their pre
sed miniature portable EEG recorder with easily applied dry electrode technology can be applied in the home to collect data for longitudina
elihood of required transportation events. Early intervention may mitigate against the development of more severe illness that would likely

mpared to a scripted protocol. A report is automatically generated from the analysis software package presenting an adherence index expre
with its partners, will build a production prototype wireless EMG system, and verify its performance in a human study. This project's innov

ng community for many years. The application of UWB to EEG monitoring is new and innovative. It will offer a significant improvement to th
use monoclonal antibodies specific to GP88 using a variety of GP88-specific immunogens. Initial preliminary results indicate that an anti-G
dicate customized therapies for each form of the disease. The novel diagnostic techniques to be researched will allow for microscopic profi
ection of lung cancer, although multiple applications in lung cancer management are rational. Our data shows feasibility and proof of conc

owth. If the RCA generation can be reduced by >10-fold, and in a serum free environment, then c24 can provide the basis for a reliable ve

primary objective for this Phase I study is to evaluate the safety of escalating doses of AdV-tk with a fixed dose of the oral prodrug, valacyc
wo elements to the clinic research: the correlation of breath biomarkers with lung disease, and the characterization of NO exchange dynam
ft Guidance for Industry (Metered Dose Inhaler and Dry Powder Inhaler Drug Products: Chemistry, Manufacturing, and Controls Document
s. The primary purpose of the proposed work is to develop a process that reduces the cost of artemether-based antimalarial products. The
y triaging public gene expression data to progress directly to product identification and late stage clinical studies for pain therapeutics with
ase I project has three Specific Aims: First, we will develop a new DiscTreadmill hardware with piezo sensor and wireless data collection and
l and locomotor detections, and piezoelectric sensors for sleep/wake monitoring. 2. Develop a uniform graphic user interface and intuitive
ssue survival and proliferation; and 4) targeting injected cells to tissue microenvironments that are most compatible with engraftment and
FBM's in biological fuids, test their ability to bind and retain antibiotics, verify that they do not inhibit osteoblast attachment, and quantify
y, we believe these peptide coatings have the potential to promote the attachment of endogenous growth factors and cells onto the surfac
. These studies, upon successful completion, will validate the utility of IFBM technology in the development of a point of care stem cell isol
y. 3. Activity Assessment - the system will be able to determine the average activity for an individual and send alerts if there is any significan
 er membranes with Perlecan domain 1 expression constructs within clinically acceptable parameters, 2) to compare in vitro cellular expres
in vivo. This Phase II project proposes to develop important modifications to the prototype Perlecan D1 expression construct, to identify o
tient education, and museums. Our specific Phase II aims include working with content experts, educational researchers and practitioners,
nt frequency of the crystal decreases with the increase of the mass deposited on its surface. This phenomenon provides the mechanism to
ess while reducing the storage requirements needed for the speech database. Aim 3 - Evaluate the quality (intelligibility and acceptability) o

e data are critical for discussions with the Food and Drug Administration that will lead to successful clinical trial design and an Investigation
ciency of clinical research, operate reliably in heterogeneous environments, and enable new types of research by bringing together dispara
the characterization of delayed swelling hydrogels generated using these biodegradable cross-linkers. These cross-linkers will be incorporat
ple preparation and multiplexed immunoassay procedure within Akonni's fuidic development model sub-circuits; determine cross- reactivit
ample-to-answer result in 2 hours or less at an input target concentration of 103 TCID50 mL-1 nasal swab, throat swab, or nasal lavage. Suc
erility in mock MEA cultures and for ability to maintain and even experimentally manipulate MEA cultures of organotypic suprachiasmatic
ram will be to build the prototype detector and integrate the digital measurement functions. The proposed plate reader would simultaneou
develop software to run on a "palmtop" computer for data analysis and user interface, and measure TBI biomarkers in cerebral spinal fuid.
s. The goal of the proposed Phase I research is to demonstrate the feasibility of developing the novel scintillator in the described microcolu
First, it improves utilization of the neutron beam. Second, it will provide better spatial resolution (less 1 mm) thus it will improve the resolvi
n- sensitive. Because poor oxygenation (hypoxia), which is a common feature of locally advanced solid tumors, can be utilized as a biomark
threat to human health, especially in children. As unlikely as it seems in the 21st century, one of the remaining major sources of lead is in
nanoparticulate powders and to define the consolidation conditions under which the desired material properties can be achieved.

gies will have a major impact.

could be found in non-destructive testing and secuity scanning at entry ports and strategic facilities. The goal of this Phase II project is to
sign. We have partnered with Harvard, Columbia and Pfizer to keep our research effort focused on problems that actually matter for genom

e ELISA kits for quantitation of anti-D antibodies and to standardize RhD immune globulin (RhIG) manufacture.
prevent alcohol-induced neurodegeneration in an established rat model of binge drinking. In this aim, we will refine transdermal delivery
and dental devices.
nt solid nodules with, it is likely that a majority of radiologists in the U.S. recommend that breast US be used only to determine whether a l
TA-NT-MSH and a control DOTA-nonspecific peptide, 3) determine the biodistribution of DOTA-NT-MSH and DOTA-NDPMSH peptides in me
esearch. -Relevance This Phase I grant application and a follow-on Phase II application proposes to increase the amount of radioisotopes re
ty of incorporating glycan microarrays into AlphaSniffer's platform and will enable the Phase II research and development to design and de
de screening against sera from patients with particular autoimmune diseases can lead to the discovery of new autoantigens, the developm
vel. Dr. Richard D'Aquila's laboratory at Vanderbilt Medical School, recognized internationally for its expertise on HIV-1 drug-resistance, wil
ne, tumor and stool DNA; ii) Enhanced ability to perform multiplexed MASSIVE-PRO using MS-MS sequencing. During Phase II, research wil
tutions. Studies performed using these improved assays on normal and mutant cDNAs as well a limited number of NF1 patient samples rev
ssible from the current PrCa patient workfow: 1) fixed and embedded biopsy tissue, and 2) nitrocellulose prints ("tissue prints") of prostate
decisions necessary for effective treatment of leukemia and MPD patients while improving clinical laboratory workfow and reducing costs.

ditional detergents in aqueous solution to form a new class of bicelles that confer native stability and structure to solubilized KOR and othe
nd another's, via health care worker's hands, will be broken. Then the approximately 90,000 U.S. deaths per year, and other costs due to ho

pplication is to couple targeted proteomics to in vivo efficacy studies in order to identify a lead candidate (Ang 1170 or one of its analogs) w
e eventual goal of bringing an SF/HGF mimetic to clinical trials for the treatment of progressive renal disease. A small molecule anti-fibrotic
and preserves organ function in vivo. In addition, Refanalin can improve success rate in liver and kidney transplantation in our animal mode
wly prepared ANG 797 analog with a different substituent at the 4 position, shows 12-fold greater inhibitory activity and increased specifici
in vivo. Our preliminary data indicate that Ang1170 has the potential to decrease the expression of fibrotic markers in vitro and decreased
In vitro, Ang797 inhibits endothelial and tumor cell growth and, most relevant here, HGF/SF-induced angiogenesis. In the rat model of coll
GF/SF, scatters renal cells, induces endothelial, epithelial and Schwann cell proliferation, and protects against apoptotic and necrotic cell de

man prostate and breast tumor mouse models have highly significant survival increases when treated with A1. The goal of this application

industry and could also address some of the government's biodefense requirements for very rapid production of large quantities of vaccin
ndness for individuals in developed countries over 50 years old. It already affects more than 13 million people in the US, including one-third
anti-proliferative potency, adapting the selected PG analog to an existing topical delivery vehicle, and comparison of three topical therapies
ft models. The data generated from the proposed studies will advance the development of this potential therapeutic agent for hormone- se
p. This can be a sign of difficulty moving air in and out of the lungs. Currently there are no convenient, accurate, inexpensive methods to de
his Phase II project, we will evaluate the therapeutic activity of the SK inhibitor in two additional in vivo models of ocular disease, including
on pancreatic islets (ApoFasL therapy) using ProtEx(tm) resulted in the prevention of graft rejection and treatment of chemically-induced di
s, a novel technology designated as ProtEx(tm) has recently been developed by the Principle Investigator of this application. ProtEx(tm) invo
n platform technology for ApoImmune. If ApoVax104-HPV proves effective in these initial proof-of-concept experiments, the Company will
market, a $36.9B in 2004.
e and optimized Detect- X(tm) software will be designed and implemented by Emerald BioSystems (Bainbridge Island, WA). This software w
he course - A 2-tiered approach of evaluation will be used. First, competency based paper and pencil testing will be administered before an
and provide effective supportive care. During the clinical evaluation we will place the new display in the ICU room and observe and record c
ed, use of the PkPd Display could result in fewer hypertensive and hypotensive episodes, fewer adjuvant drug interventions, a lower inciden

pping systems with the second generation technology to deliver upgraded surveillance traps for real-time detection, reporting and unatten
ugh both receptor-mediated and non-receptor mediated pathways, microarrays can help to elucidate signaling pathways that are affected.
nstrate the feasibility of developing a biodegradable polymeric formulation of drug(s) coated on a self-expanding metallic stent. The specifi

When completed, the system will be commercialized by marketing it to life- science laboratories, forensic laboratories and hospitals. In Phas
will be populated (and automatically updated) with information extracted from publicly available literature resources (such as Pubmed, Tox
ctive activities of a human mAb against acute P. aeruginosa pulmonary infection in wild-type (WT) mice and chronic P. aeruginosa orophar
be incorporated in a eukaryotic expression vector followed by permanent transfection of cells. These phase II studies will enable productio

isplaying the torque and push/pull forces applied by a physician during colonoscopy. The technology is designed to improve colonoscopy tr
tinal vascularization in a murine model of retinal neovascularization. Arteriocyte's core business is focused on developing `off-the shelf' ste

animal MRI images for precision needle guidance. 3. Perform a feasibility study using 10 mice to demonstrate the ability of the robot to bio
s. Episodes of severe hypoglycemia contribute significantly to the morbidity and mortality of individuals with type I diabetes and recurrent
will be the field personnel likely to be exposed to OP pesticides and clinical laboratories likely to encounter patients that are suspected to ha
ons from Aim 1 (as per FDA recommendation). Aim 3: Determine the relative efficacy benefit of cell therapy in minimal, moderate and seve
nt/vehicle in the buprenorphine solution is absorbed at the injection site or is carried away by the aqueous body fuid. The underlying hypo

RA and should be even more specific. Specificity and multiplex capability are key features in targeting regions that are putatively unique to M
 similar to other audiometric earphones to avoid significant changes in the frequency content of stimuli used for speech tests. During the Ph
and chemical properties of most cyclic peptides makes them unsuitable for cost-effective modifications, using currently available synthetic
ivery system for this class of drugs. This system could also be used for other drugs where chronic delivery is essential.
he formulations in animals. The demonstration of sustained release of tacrolimus (3 weeks) or cyclosporine (1 week) in the absence of clinic
table dosage form of apomorphine. Completion of these aims will constitute a readily identifiable milestone that will continue in Phase 3, i
a high-molecular-weight TGF-a peptantagonist derivative we have recently developed that has excellent solubility and potent antagonist ac
CT imaging test for AD will yield significant scientific, commercial and societal benefits. RELEVANCE Successful accomplishment of this Phas
MAT-2) is expressed in beta cells in pancreatic islets and is the target for dihydrotetrabenazine (DTBZ). We have now synthesized a highly po
allograft preparation method (already developed for rat tissue) to goat nerves which more closely mimic the size and complex structure of
n of IV/oral administration. Our dose escalation toxicology studies show encouraging safety data for AK295. Here we will perform the nece
ncomplete deliverables, changed objectives or strategy; No-go: terminate the project. In addition to the milestone review, the SET will also
erated and preliminary data show detection of these markers also in mild and moderate TBI patients. The data supporting the developmen
assessment method will be assessed. Volunteers will be asked to complete usability surveys, the information from which will be used to im
nd dysfunction. Presently, assessment of GMs is based on the Gestalt evaluation of video-recorded infant movement patterns. Assessment
fit to the field of pain assessment. Current pain assessment questionnaires are often time consuming to fill out. A device, such as the Know

ng spore outgrowth as a parameter. Task 3. Conduct experiments designed to extend the use of F-spores for sterilization processe

A logic with the mass storage system, modeling the performance of the new architecture, and development of software control that can ra
y low cost. Our pricing structure (a one time fee) also will put this suite of programs at an advantage relative to its competition and make it
ping a web application for SMART Recovery would be innovative. Neither we nor the principals at SMART Recovery are aware of any other
sample of Hispanic adolescents, generate national normative data and actuarial profiles of the HSI-A; 6)Assess the reliability of the HSI-Ath
ation (BA) is an evidence-based practice for depression that may have important transportability advantages; this project aims to develop i
latively small percentage of this population will receive such treatments. Panic Control Treatment for Adolescents (PCT-A) is one efficacious
ate discovery of more selective therapies for these and other diseases, we are developing novel screening assays for a family of proteins, ca
ng chronic infammatory disorders such as arthritis and infammatory bowel disease. Responding cells migrate toward higher concentratio
ocytochemistry methods and fuorescent imaging will be the key methods used for analysis. Finally, the fF-RTD will be fully validated for hig
pose of screening for biological mediators in the future phase II study. Our ultimate intention is to commercialize the identified biological m
t has the potential for the treatment of both primary and metastasized prostate cancer.

nees modulate their level of exertion to follow customized target trajectories that are visually displayed along with real-time force-position
rocardiography. In accordance with the intent of the SBIR program, the ultimate objective is an instrument that can be sold to laboratories

ch enzyme will be carried out. These results will establish the foundation for dramatically expanding the number of cloned ene reductase e
ng it lighter, wireless and compatible with a wider variety of lesion shapes. We will complete a Phase II Clinical Trial with at least 300 patien
t will be a full functional prototype system consisting of a robotic placement device, a dedicated MR coil, and software to control the syste
pecific Aim 2b will evaluate current LabmatrixTM software development tools and practices. Phase I, Specific Aim 3 will compare key eleme
he assays we propose to develop will be able to identify the emergence of secondary EGFR mutations in patients. These assays would use
mbers of initial copies are present. Moreover, the enzymes used by pWGA are also replicative polymerases, therefore we expect pWGA will
ogical samples. Potential applications of the technology developed in this project include disposable devices for single and multiple sample
olog Microbial Identification System, which is now installed in about half of US State Public Health Labs and is frequently used to identify le
tion with the PDA, complete the clinical study, and apply to the FDA for 510(k) clearance to market. In parallel to these efforts, BIOMEC wil
scitation in the rat, an accepted model to study hypovolemic shock, that a small volume of 4 ml/kg of HS combined with anti-ischemic com
of HAF, and to determine the extent to which this agent promotes adhesiveness between tissue and damaged surfaces in the presence of p
endly interactive software prototype for space-time exposure reconstruction. This prototype will allow health researchers to visualize, analy
tial benefit of this research is its utility in accessing, linking, mapping and analyzing diverse population-based and individual-level data inclu
 more concise and accurate description of clustering of cancer cases that accounts for risk factors, covariates, residential history, cancer late
gration (MEMS sensor, ASIC & biocompatible materials) and product validation and testing. In conclusion, with this telemetric IOP sensing t

rapid cloning and expression of peptide antigens fused to the carrier immunogens. We will use protein-engineering techniques to improve
n to screen and optimize a combination of immunodiagnostic peptides and prepare for validation of new immunoassays in both ELISA and
cle of the tick vector and assess different vehicles for bait delivery. Lyme disease is the most prevalent vector borne infectious disease in th
able to quickly enter the market-place.

an in vivo swine model of myocardial ischemia and reperfusion.

DA regulatory guidelines so that it can be suitable for commercialization as well as future clinical use. In addition, we propose to carry out a
uality of the patients' life.
entional and handheld delivery optics, and also markets a tabletop microscope-based 1300nm wavelength OCT system for small animal im
n. As with existing gold standard HIV viral detection methods, such as RT-PCR, BioScale's proposed assay has two distinct applications: qua
dly engineer bacterial chromosomes with long synthetic DNAs would have broad implications in human health. Potential applications of the
detection of proteins such as western analysis and ELISA. Principle objectives of this Phase II grant are to assemble a functional, simple, ye
n the brains of awake freely-behaving human epileptic patients, artifact-free recordings during movements and peri-ictal events cannot be
develop and evaluate a VT based synthesis system. The project will use high- quality and home-video quality recordings from male and fem
ngerprinting. The goal is to identify fare up before it becomes clinically apparent and thus prevent the symptomatic fare-ups with damage

ed Entertainment-Education strategy to promote education about cancer, BTC will now proceed with the Phase II proposal to launch a profe
well as broaden the range of therapeutic agents that can be successfully administered via the respiratory tract.
bial community analysis of a variety of sample types. Including nucleic acid isolation, data acquisition and analysis, identification(s) should b
s to optimize conditions of radiation-based sterilization methods and to validate the efficacy of sterilization. IV. BioTex engineers will design
aspase-3 activation in live cells and correlation of caspase-3 activation with other cellular events. They also provide novel tools for directly
ell recording configuration. It is important to note that the model that we derive from our approach will not actually copy what the expert
sion experts Drs. Don Fletcher, Melissa Chun and Ian Bailey will work with the RERC to guarantee a practical product for the target audience
on for glenoid placement by comparing the new system against standard surgical practice in a series of mock surgeries on foam bone mod

oactivity. We also performed a pharmacokinetic study to verify that PEGylation extends the circulating half-life of sFlt-1. During Phase II, w
at limited imaging resolution. A successful completion of the proposed project will provide the enabling component for better resolution im
method to diagnose and exclude PE at the bedside, especially in patients at risk for PE. This project will fund a clinical study designed to tes
mation for a wide range of microorganisms. Phase II will extend these results to create an antimicrobial surface that will inhibit biofilm form
saliva; 2) Extensive cellular toxicity, genetic toxicity, and animal toxicity studies will be performed to examine the safety issue of the anti-S. m

oteins remain very difficult to test. Thus, even though tethering a protein [as with surface plasmon resonance (SPR) systems] can lead to inc

oise, solid and bulk waste disposal practices, and handling and storage of toxic and hazardous materials.
ughput cell protection screen based on the toxic effects of G93A mutant SOD1 expression in PC12 cells. (2) Identify compounds that block
ets >3), is toxic ideally only at concentrations > 5x the effective dose and produces protective effects when tested on primary neurons subj

ntroduction of a Human Hydration Monitor into the healthcare marketplace.

mmunosuppressed pigs. Thus, the critical objectives are to obtain vital proof that the human CPCs can be induced to create new cardi
fic aims 1 and 2) of the project involve the in vitro characterization of the nanoparticle system; including activity and release of drug from n
e cerebral oximeter, since commercial cerebral oximeters currently approved by the FDA are for trending only monitoring. In addition, w
ofessionals (n=40). The proposed research will address the urgent public health need for efficacious, individualized, and cost-effective preve
tiple low dose injections of U-CORD-CELL" into transgenic PSAPP mice will provide a rescue of behavioral deficits, which will be correlated w
ies will consist of technology transfer verification in Specific Aim #1, demonstration of functional human a cells in Specific Aim #2, and expa

during cryosurgery. Successful completion of Phase I and 2 will lead to the development of the CryoInject(tm) system which can then be us
olTM as a nerve-sparing concept using a canine cryosurgical model. Successful completion of Phase I and 2 will lead to the development o
oSite(r). This project has the potential to vastly increase the number of known acetylated-lysine sites and to greatly stimulate the newly em

modifications now being discovered. We will also release modifications discovered in our laboratories to the scientific community to furthe

gy to identify cytotoxic peptides specific for cancer cells. Under Phase I funding, we initially propose to develop a pooled phage library disp
we will use our newly developed FV siRNA library technology to identify synthetic lethal interactions in cancer cells. Genetic screens with F
ned into lentiviral vectors. Genetic screens with FV siRNA libraries have the potential to greatly simplify validation of gene function and sign
ancies or as a preparative regimen for hematopoietic cell transplantation is often accompanied by the severe consequence of gastrointestin

col for simplified sample preparation that is less expensive, more effective and suitable for resource-poor regions. If successfully developed
lab of Dr. Craig January and is currently a widely accepted tool for cardiac safety testing. Research in Dr. Tim Kamp's lab has demonstrated t
rous counterfeit medicines at the point of sale. Centice proposes to develop a fast, accurate and affordable system for spectroscopically ide
to create highly sensitive, multiplexed detection of a variety of biological targets. In this grant, a complete handheld, multiplexed, lateral fo

with notable antibacterial properties. Both prototypes are based upon a ketolide scaffold known as non-inducers of macrolide resistance (
ntial cardiotoxicity due to long QT prolongations resulting from inhibition of hERG channel function or trafficking and to inhibition of repola
safety and efficacy of this new technology will be further investigated during a Phase II study in which the design of the solution used to p

c screening assay for anti-EA is commercially, scientifically, and socially important because of the large number of chemicals (>10,000) - mu
reatment of retinal NV. Our objective is to develop more potent, selective anti-angiogenic drugs, which can prevent and arrest retinal NV. T
at risk to develop DR. Diabetic retinopathy is the leading cause of new cases of blindness among American adults between 20 and 74 years,
tinal vascular leakage when compared with thalidomide and the other two compounds. Based on these results, we hypothesize that Compo
cific aims of the Phase I studies will result in a prototypic test and establish the feasibility of proceeding into Phase II evaluations: 1. Using a
nsive nucleic acid labeling and optical/fuorescent detection equipment. The proposed device is well suited to micro-scale systems that can
ons based on small-molecule inhibitors of the enzyme acting by increasing fatty acid degradation by oxidation or decreasing fatty acid synth
hrough contaminated drinking water. Our technology will allow communities of all sizes a simple and cost effective source of arsenic-free d
o deliver prematurely. Early risk assessment, when there are no conventional symptoms of the delivery, will allow appropriate preparation
EACH to quantify its value to both patients and clinicians. The commercial potential for TEACH arises in large part from the increasing awar

ng-term goal (at the end of Phase II) is to have developed the necessary foundation to be able to proceed expeditiously with FDA approval
es and to correlate MHC: T cell receptor binding to resulting activation and secretion of multiple cytokine effector molecules. The goal is to

module will capture standard electrophysiology inputs. A voice module will utilize a wireless microphone to capture quantitative speech fe
c drugs in vivo versus in vitro. This will be performed by measuring the penetration of drugs into the naive rodent brain compared to DIV-BB
e used in Phase II. In Phase II we will further expand the website content, develop programming needed to enable all interactive tools and
Emergency Medicine Physicians and Pediatricians. The Specific Aims of the proposed Phase II STTR to assess suicidality are to: 1) Refine the
deficits, including impaired memory function, are strongly linked to the long- term disabilities found in patients with schizophrenia. Treatme
compound, COG133, which is a novel peptide fragment of apolipoprotein E, for its ability to modulate microvascular amyloid, neuroinfam
y, but are often debilitating for patients to the extent that they greatly alter their quality of life. We have found that clinical and histological
disease. In this proposal, we will test COG133 for treatment of PD via a novel mechanism. This approach to PD therapeutics represents a p
signaling (phospho-JNK, phospho-IRAK, phospho-P38). Successful demonstration of improved mortality, reduced harmful infammatory res
cuprizone model; 3) Specific Aim 3: We will examine if COG112 can prevent infammation-induced oligodendrocyte precursor cell death in
s affect the function of antigen-presenting cells; and 3) how COG compounds modulate the phosphorylation of MAP kinase JNK, p38 and tr
e candidate formulations developed under Specific Aim 1 will be tested for tensile strength, Young's modulus, and pore diameter. The targe
r surfaces. A spray tip will be developed which can predictably and reliably disperse a viscous fuid when attached to a syringe delivery dev
to the skin over a vaccine injection site that will make vaccines more effective. As stand-alone adjuvants, if our topical DC activators are fo
rrier sentences, speakers, and target words will be developed in Phase II. In addition, the Phase II system will also have the capability of pre

clude modeling and system design to enhance overall purification; long term testing plus extended solvent leaching tests; develop enhance

rarin derivatives. 2. To evaluate puerarin and its derivatives for their sodium ion glucose cotransporter (SGLT1) and facilitated glucose transp

The proposed instrument will have a significant impact in the CI field because it will enable the practice of evidence-based medicine in sele
duction reduces the gas load and permits the use of recently available light weight miniature vacuum pumps requiring low power for their
dults with chronic pain. The program is based on fundamental cognitive-behavioral principles that have been effectively applied in clinical p
es using carefully tailored computational methods. Thus, Phase I is concerned with the formulation, software implementation and testing o
quality of the wound seal, the extent, if any, of collateral thermal tissue damage, solder stability and biocompatibility. The current method

enter for precision manufacturing of the less robust forms of device, and mechanically test these devices to confirm the predictions of the

n public health research where outcome measures are needed that are comprehensive and sensitive to meaningful change related to interv
ring support for one or both stabilizer designs. Phase II will focus on the development of prototypes of the stabilizers and the evaluation of
der to explore different paths to commercialization..
will include recruitment of three (3) subjects that have experienced a stroke who will each participate in 3 sessions of FES-augmented NuSt

he success of a Phase II. One area that has a potentially huge demand for noninvasive methemoglobin sensors is the Neonatal Intensive Car

e and product application on LEAP. In biopharmaceutical manufacturing, over $40 billion worth of therapeutic proteins are produced annua

y functional cartilage within a brief period of in vitro culture and (ii) resurfacing of an entire joint instead of a focal defect. The ultimate goa
ill its own tumor. While this project is targeted at the destruction of melanoma tumor cells, the High Throughput Screening system we prop
models, sites of action as well as consideration of other applications (e.g. migraine). It is our intent to improve the current therapeutic optio
ed from persons with risk factors for vascular disease including a history of smoking, hypertension, and diabetes. In this way we will pro
oluble precipitates have been successfully encapsulated and proteins that are relatively unstable and therefore incompletely folded in vitro
with AS/HFA. We will also write the full content for the facilitator's guide and student workbook for one module of STRIVE and film the vid
technology, to enhance relapse-prevention options. To accomplish these goals, the specific aims for the Phase I period are to: 1) Conduct a
ters, and brochures; conduct focus groups with cosmetologists and clinicians; and modify them as suggested. We will also conduct feasibilit
e content for one module of the Web-based training; (3) develop detailed outlines for the other modules and the intake process with teleph

to incorporate recommended changes to Youth LIB; develop and incorporate family content into the core psychoeducational sessions; deve
tudies with complex data structures. Manuscripts and course packs will be developed to assist practitioners in applying appropriate method

the feasibility of producing an innovative learning and support program that will provide 11 year-old to15 year-old teens with CF with hea
of empowerment, their level of emotional burden, and their level of hopefulness compared to a control group; 4) Obtain appraisals of the
and teachers to determine the effectiveness of the MSC program in increasing knowledge and protective attitudes and intentions toward a

g for coping with sleep behavior disorders extends the ability of families to care for their loved ones in the home, significantly reducing exc
e existing AllocateChina system. Current data on the spatial distribution of population in a GIS format is critical in planning and evaluating n
le instrumentation (D'granulator, patent held by Dental Designs of Dallas) and the adaptation of medical ultrasonic "chopper" technology (
multiple sites within Greek and university systems; (3) available components for refresher, problem-focused or incident-driven trainings; (4)
ealth professionals. In Phase II, we will revise the web- based training program based upon input from Phase I and expand it to cover the fu
a and the military and traveler markets have promise for reasonable commercialization.
nditions, and access to care. Anyone who plans services for an aging population and who must account for an aging community's shifts in r
hose used in developed countries
f this Phase I study will lead to a Phase II program for testing multiple diabetes patient plasma samples for novel biomarker discovery, assay
for phage display selections. Phase I has 4 specific aims, each of which will optimize a particular step in the phage display portion of the DC

an important longitudinal measure of a patient's mood that will be closely related to established depression rating scales. This innovation w
with an approach to develop a new generation of protein kinase targeted drugs.
ide the foundation of future phase II studies to optimize the assay format for HTS and initial drug discovery efforts against these different re
to liver cells in mice.
ression of the FANC-C gene in hematopoietic stem cells of FANC-C deficient mice as a model for SB-mediated gene therapy for Fanconi ane

n-capable hardware will be performed at an aluminum smelter. All field study personal exposure data will be managed by the web- based s
matode biosynthetic pathway will be expressed and inhibitors identified through a combination of high-throughput chemical library screeni
trument including 120 miniature microscopes. Liquid-lens technology, combined with DMetrix's ultra-rapid, automated array-microscope te
OMP. ThermoBLAST will be integrated into our OMP (Oligonucleotide Modeling Platform) software resulting in automated design of more s
ts with a visual check that the planned pattern of radiation is suitable for the patient. This device will therefore reduce the potential for unw
e based on full-wave, finite element simulations of the loaded coil using well validated full-wave software. The effort will build on our exten
periments at 900 MHz. The Phase II, 4 mm, 900 MHz probe is expected to demonstrate the following: (1) ability to generate sustained rota

fit from a reduced lifetime x-ray dose.

ectors. We will choose an optimal structure by performing simulations and then measuring the actual performance of the structure on high

g databases from the Syncope and Falls laboratory (SAFE) at the Beth Israel Deaconess Medical Center and from the University of Cambridg

mond machining. If Phase I is successful, Phase II of the project will improve the process and fabricate some prototype biomedical products
he use of a QMR-based (Quantitative Magnetic Resonance) EchoMRITM system for infants designed to provide the most precise measurem
the target peptide. This work also revealed some cross-reactivity of the target peptide with the human neutrophil elastase (HNE), a host in

integration of the DNAzyme sensors with the standard storage and transport aeration system used in grain containment units, which will in
ost matrix metalloproteases in vitro. HG also protected epithelial cells from bacteria-induced cell damage in a tissue culture model of infecti
stidine tag for purification. This HisSLPI construct has been integrated into the tobacco genome, and multiple lines have been demonstrate
be the demonstration that the model proteins can be crystallized, an important and demanding endpoint. These studies will use dimeric p
se students will either drop-out of school or continue to struggle throughout their school careers and into adulthood. Low literacy has bee
establish the specific embodiment, or combination of embodiments, for which the new lipid on glass nanopore configuration can best be ap
on Standards. As science and technology are pillars of our society that maintain our current standard of life (and that of generations to com
organochlorine pesticides and EIC Laboratories has detected organophosphate pesticides in vapor and aqueous phases. Field detection of
blishing membrane production methods, demonstrating the underlying optical imaging phenomenon, establishing quantitative assay chara

ect will be the development and testing of the software package itself, we also want to enhance the desirability of this package in the eyes
"experience buffers" described provide an alternative for presenting behaviors of children with autism in their usual school environment. H
se Program Phase I STTR grant. At present, the antibiotics produced by these anti-MRSA clones have not been characterized. The specific ai

onstraints of line prevention staff. Feasibility will be tested through systematic assessment by a panel of experts, and through a small test o
he proposed Substance Abuse Consequences Decision Support System, 2) develop a fully functioning online prototype using California data
. Based on recommendations of actual users of AAC devices, we will develop 5 voice gestures (contrastive emphasis, loud and clear reply, t
simulations, and (3) validate the device's performance against a standard bench- top optical system on synthetic breast tissue phantoms, an

aneurysm can be improved by shortening the time to complete occlusion.

uld lead to more rapid advances in drug discovery, disease diagnosis, disease treatment and better understanding of the fundamental cellu

a variety of standard diagnostic methods for particle and bacterial detection such as epi-fuorescence microscopy, bulk fuorescence, cultur
methodology will be an effective tool to prevent arsenic related disease from drinking water exposure. In the United States and globally, co

ey can share their reactions in a discussion format. In Phase II we will complete the development of the exhibit, adding representative drug
ntial to study a broad range of clinically relevant issues in transfusion medicine, such as HDN, transfusion reactions, and IVIg therapy. In add

athing only, relatively less effect from airfow leak than in FO, and it provides an order of magnitude more measurements than Rint. APD ca
y of many human diseases because of its anatomical, genetic and biochemical similarities to the human. It is also used for drug screening,
peutic approach for reducing risk of reocclusion and reinfarction following fibrinolytic therapy for MI. The successful completion of Phase I
tical industry. Drugs in this class are being used to treat cancer and infammatory diseases, as well as infectious disease. A further extensio
t and lead to an efficacious therapy for brain tumors. It is also hypothesized that efficacy will be further enhanced by combining the gene t
d in Phase II. Long-term goals of this translational research project are to develop an active lacritin construct as an efficacious, nontoxic top
asurement capability to protein isoforms from 20 gene families, and investigate two additional cancers such as lung and ovarian. The expan
tant for CD4+ expressing T cells approaching zero and is thereby capable of CD4+ cell capture. The total HIV positive patient population wo

f FVIII constructs bearing multiple epitope modifications (combinations of the modifications identified during Phase I). These research and
trumental conditions where maximum chiral separation can be achieve, to demonstrate the separation of different classes of biologically a
of this proposal is to expand these findings to refine, construct, and examine the performance characteristics of a mini-GC coupled to an EB
tified in Specific Aim 1 are suitable for MAMS in humans by sequentially analyzing the concentrations of taggant(s) and taggant metabolite
overall goal we propose the following specific aims: AIM 1: Synthesis and Characterization Gd3N@C80 Atherosclerotic-Targeting Endo

lung, prostate and breast cancer. The goal of this proposal is to advance the development of a blood test for cancer based on the identifica
her industrial biotech applications, to allowing greater agricultural production, permitting more efficient and safer energy production, and
nd many other biotechnology applications. The technology that will be developed in this project will elucidate path- ways leading to the bio
generated by combinatorial mutagenesis of select residues within the FABP binding pocket, using the Phase I UCB probe as a template. Prec
 d approach to restoring normal progression of wound healing in diabetics. Milestones for Phase I project: 1. To determine whether or not
ast decade through the creation of platform chemical technologies by scientists at the Foundation for Applied Molecular Evolution. Such tec
molecular data to be collected than is currently feasible.

em for accuracy to objectively assess the system's performance. The company will also evaluate nurse and patient attitudes toward using th
ations in real-time medical diagnostics and wound healing. Tissue engineering creates functional biologic prostheses by growing cells that f
scientists, especially for dug, diagnostics, and vaccine development. The work proposed in this application represents a significant step tow
uspension cells in a controllable manner. We aim to further develop our platform for its original application as well as for its newfound appl
y. Advanced website features include features for prospective and current clients. For prospective clients, information on the products, pric
e valve to demonstrate detection, response and control of IOP in the normal and pathological pressure ranges. Implant the valve and test i
n. In Phase II, functional validation and characterization will be performed on these host genes by recreating the gene perturbation in na ve
ruments' mission to develop precisely what is needed for the many-channel RF system, their core competency and that of their collaborato
tor), subserves a beneficial (cell survival promoting) effect, while the other, a membrane androgen receptor (mAR), promotes cell death. Su
y activity at a human cardiac ion channel, called hERG, potent activity at which would preclude further development; and inhibitory activit
 test verification at discrete points. Since there is no software can be adopted from existing RWD, two new software packages will be devel

mum end speed scenarios. AMT will also seek to use this phase to grow and diversify its team. AMT plans to conduct a peer review of its m
oned since terrestrial commercial applications are more concerned with the economics of time, and mass and power are typically free var
ch will have commercially available environmental contaminants in applications ranging from assessment characterization to monitoring o

tional performance in a finalized module configuration, and conduct membrane manufacturing development while assisting our commercia
d of Phase II, Eon Research will have commercially available environmental contaminants in applications ranging from assessment characte

tional performance in a finalized module configuration, and conduct membrane manufacturing development while assisting our commercia
ring the test and development effort. Although the IWCP team will be working in an isolated test environment, data validation and process
lood compatibility model will also be used to compare polyurethane valves with tissue valves. In depth fuid dynamic studies on critical are

two interactive courses, a web portal of pressure ulcer information, and job aids and other performance support tools to increase perform

ariety of self adjustable positions to promote independence with dressing tasks and propulsion, while providing seated comfort during wor
emical space. The use of recent techniques in graph querying and mining will enable data analysis that can scale to millions of compounds.
k with the HRS Data Release Protocol Committee and SSA to develop appropriate certifications of the statistical disclosure avoidance provid
aims, the proposed Phase Two work will be directed towards i) developing/optimizing scalable manufacturing methods to produce a 128 x
ly, Phase I of this SBIR project consists of the following Specific Aims: 1) Utilize light stress to induce preferential photoreceptor cell death in
y to show these rankings correlate with in vivo literature data. Demonstrating that we can predict (photo)toxicity (or lack thereof) in a smal

odologies using Medicare and/or Medicaid files; (5) produce plans for the development of research data structures that incorporate inform
a privacy, recognizing that each survey must satisfy not only a common set but also its own unique confidentially requirements; (5) comple
kits for conjugating biologically significant carbohydrates to generate a wide range of glyco-nanoparticles. The conjugating kits include the

totype design to 1) minimize its commercial manufacturing cost to benefit families of limited means and 2) validate its performance in actu
ve substances such as alcohol, amphetamine and nicotine.
e cells to continued harmful enzymatic action while the system is cooled, 2) the inability of the shaker to dissociate the pancreas uniformly
ed as a potential biological weapon and is included in the list of category B priority agents. Currently, there is no effective treatment for the
ory and visuospatial memory. Preliminary investigations with the AMP prototype systems have resulted in inquiries from a wide range of re
e in the identification of patients at-risk for OSA. The ARES provides a cost-effective method for dentists and dental sleep specialists to test
pt for use of this new non-invasive therapy to treat and prevent IDH and provide the foundation for a larger study focused on reducing mor
uid Logic, Inc. is developing a lab-on-a-chip that integrates clinical chemistry, immunoassays, DNA amplification, and DNA sequencing on its

ditions, while similar to their predecessors, are optimized for small cell phone screens and keypad input. Increasingly, media and tools that
me to collect data for longitudinal surveys of the elderly.
e severe illness that would likely require inpatient hospital care in a pediatric intensive care unit (PICU).

enting an adherence index expressed as percentage of the number of deviations between the recorded and scripted movement sequences
uman study. This project's innovation stems from AME's ability to integrate all the functions necessary to perform wireless EMG data collec

r a significant improvement to the field over the slower existing technology. No comparable device is currently available.
ry results indicate that an anti-GP88 antibody can abrogate GP88 functional activity. This phase I SBIR application is focused on fully charac
d will allow for microscopic profiling of tiny amounts of tissue for numerous cancer-causing molecules. There will be applications in pre-clin
ows feasibility and proof of concept that supports the rationale for further development and testing of this approach. A subsequent Phase

rovide the basis for a reliable vector production system with a further improved safety profile that can be widely used to manufacture ade

dose of the oral prodrug, valacyclovir, and standard radiation therapy. Three dose levels of AdV-tk, ranging from 3x1010 to 3x1011 vector p
erization of NO exchange dynamics in the respiratory system and its relationship to lung disease. The proposed breath analysis instrument w
cturing, and Controls Documentation, CDER, 10/98). Our proposed CO2 propellant MDI devices will create competition so that the entire fu
ased antimalarial products. The core technology will also be commercialized for other applications. The specific aims in phase I are 1) dete
tudies for pain therapeutics with new mechanisms of action. Neuropathic pain patients tend to become globally disabled and are heavy us
and wireless data collection and control capabilities adaptable for both EEG/EMG- and/or piezo-based sleep restriction in mice. Second, w
phic user interface and intuitive programs to enable automation of the touchscreen procedure, data acquisition, and integrative analysis of
ompatible with engraftment and survival. The goal of this Phase I SBIR proposal is to validate an IFBM approach to enhance engraftment of
oblast attachment, and quantify the coating density of peptide and antibiotic on metal surfaces. In aim 3, we will characterize the anti-mic
factors and cells onto the surface of bone grafts. The goal of this proposal is to demonstrate that bi-functional peptide coatings can improv
nt of a point of care stem cell isolation device. Although beyond the scope of this proposal, we envision the addition of IFBM's that bind ost
nd alerts if there is any significant deviation from the individual's baseline or deviation from a pre- determined baseline. This function will b
 compare in vitro cellular expression of, and cellular responses to, the Perlecan domain 1 construct generated by membranes loaded with t
pression construct, to identify other effective bone graft materials for co-delivery with the Perlecan D1 expression construct, and to test th
al researchers and practitioners, and assessment experts to: 1) scale up content by incorporating more human systems and creating comple
non provides the mechanism to directly measure the Particulate Matter mass concentrations. The collection, recording and transport of th
(intelligibility and acceptability) of automatically created voices for a representative sample of individuals who can benefit from this techno

trial design and an Investigational New Drug Application. This research addresses a significant problem with opioid analgesics, which soluti
arch by bringing together disparate research tools and data.
e cross-linkers will be incorporated into existing hydrogel technology to generate delayed swelling hydrogels. These hydrogels will be tested
rcuits; determine cross- reactivity of target antigens with Quidel antibodies in the competitive protein array; determine limits of detection
throat swab, or nasal lavage. Successful demonstration of an integrated, multiplexed RT-MME-PCR chip in amended clinical samples will lay
of organotypic suprachiasmatic nuclear explant from mouse. In Phase II our goal will be to design and test a scaled-up unit, which will inclu
plate reader would simultaneously measure fuorescence intensity or fuorescence lifetime signals from all of the samples in the 24 well p
markers in cerebral spinal fuid. The resulting device will be a general technology platform for the detection of multiple proteins in a single
tillator in the described microcolumnar structure using vapor deposition fabrication techniques developed and proven by RMD. After fabrica
m) thus it will improve the resolving power of the instrumentation. Since the biological samples are usually on the order of millimeter in size
ors, can be utilized as a biomarker, the proposed contrast agent will provide an efficient way to monitor cancerous tumors. In addition, to a
ining major sources of lead is in children's products and toys. This application proposes to investigate and develop technology that can be u
perties can be achieved.

e goal of this Phase II project is to develop at high spatial resolution scintillator for neutron macromolecular crystallography, which complim
ms that actually matter for genomics experiments and early phase drug discovery. In addition we fit into the NIH's data sharing policy by ma

will refine transdermal delivery of CBD and examine its effects on both cell death via examination of Fluoro-Jade B labeling of degeneratin

ed only to determine whether a lesion is cystic or solid and/or for needle guidance. Although a well defined rule-based system has been de
d DOTA-NDPMSH peptides in melanoma bearing mice. Malignant melanoma is a serous health problem due to an increase in incidence an
the amount of radioisotopes required to support later stage research and anticipated approved drug products in therapies that are showin
d development to design and develop glycan immobilized transducers for diagnostic and prognostic purposes. Great achievements have
new autoantigens, the development of diagnostic assays to identify autoimmune disease and, ultimately, improved treatments. We have de
tise on HIV-1 drug-resistance, will serve as a subcontractor, participating in assay development and providing samples to AmberGen for valid
ng. During Phase II, research will shift to a thorough evaluation of MASSIVE-PRO on DNA derived from fecal samples including prospective
mber of NF1 patient samples revealed that these tests are highly effective with sensitivities comparable to and in some cases superior to st
rints ("tissue prints") of prostate biopsies. We will compare the yields and representation of miRNA for both samples with corresponding fr
ry workfow and reducing costs. The Specific Aims are: 1) Develop a rapid single-tube assay for the simultaneous detection of major mutati

ture to solubilized KOR and other GPCRs. These two-headed detergents are designed to be much better than conventional detergents at p
er year, and other costs due to hospital acquired infections, will decrease as well. Random Hand Hygiene Prompts will encourage hand wash

Ang 1170 or one of its analogs) within this library for the treatment of ALF. The lead candidate emerging from this study will be submitted
 e. A small molecule anti-fibrotic has significant clinical potential for the treatment of progressive renal disease.
nsplantation in our animal models. The proposed work is designed to identify a strategy to determine the protective effects of Refanalin ag
y activity and increased specificity to the HGF/SF/c-Met pathway, with better water solubility than ANG 797. In a preliminary in vivo lung tu
c markers in vitro and decreased pulmonary fibrosis in vivo. The proposed research project is designed to explore the possibility of develop
ogenesis. In the rat model of collagen induced arthritis (CIA), Ang797 ameliorates the disease course and reduces tissue damage. Our prelim
nst apoptotic and necrotic cell death. In an experimental model of spinal cord ischemia, Refanalin improves neurological recovery and prese

A1. The goal of this application is to expand the tumor types targeted by auxotrophic S. typhimurium and to determine if the host immun

tion of large quantities of vaccines and biopharmaceuticals. Kits for production of peptide libraries based on the UBL expression system co
ple in the US, including one-third of those over 75, and the problem is expected to get worse as the population ages. Unfortunately, there is
parison of three topical therapies-PG monotherapy, PG/1,25(OH2)D3 combination therapy and 1,25(OH2)D3 monotherapy (as a positive co
erapeutic agent for hormone- sensitive and hormone-refractory prostate cancers at all stages.
rate, inexpensive methods to determine how much snoring is happening, and whether the snoring is a sign of something more ominous. T
odels of ocular disease, including oxygen-induced retinopathy and laser-induced chorodial neovascularization. Additionally, we will determ
atment of chemically-induced diabetes in an allogeneic transplant model. Expanding on these data, the focus of this proposal is to develop
f this application. ProtEx(tm) involves the generation of chimeric immunological ligands with a modified form of core streptavidin, modifica
t experiments, the Company will apply for a Phase II SBIR grant to further develop ApoVax104-HPV into a lead commercial product to test in

dge Island, WA). This software will be integrated into existing Crystal Miner(tm) crystallization tracking software and relational database. Sp
g will be administered before and after training. Second, situational awareness, performance and competency will be evaluated during 4 si
U room and observe and record clinician's interventions and actions. Expert evaluators will rank order the performance of the clinicians bot
ug interventions, a lower incidence of patient movement, a lower incidence of the need for pharmacologic reversal of opioid effect to resto

detection, reporting and unattended remote sensing of adult mosquitoes in fight. This application will couple novel automated vector
ling pathways that are affected. In general, microarrays offer a direct, effective way to provide detailed data about the biological effects of
anding metallic stent. The specific objectives of this proposal are: 1. Develop preclinical animal-stents to enable proof-of-concept drug upta

boratories and hospitals. In Phase 1 of this project, key inventions were built and tested with excellent results proving feasibility: (1) the co
resources (such as Pubmed, ToxLine, and full-text journals) using extended MedScan technology. The value of the proposed system is two-
d chronic P. aeruginosa oropharyngeal colonization and lung disease in transgenic CF mice. We will first develop cell culture processes to p
e II studies will enable production of a master cell bank and development of the purification and downstream processing of the fusion prot

igned to improve colonoscopy training, establish best practices, and improve colorectal cancer screening procedures by making them safer
on developing `off-the shelf' stem cell-based products for therapeutic angiogenesis applications. In this study the company proposes to ex

ate the ability of the robot to biopsy the mouse fank as selected on the MRI images and evaluate the accuracy of the system.
th type I diabetes and recurrent hypoglycemia can result in long-lasting damage to brain function including memory loss and degradation o
patients that are suspected to have been exposed to OP chemical agents.
y in minimal, moderate and severe HI injury models. These data will help determine the appropriate inclusion criteria and clinical endpoint
body fuid. The underlying hypothesis of our research is that a long acting formulation of buprenorphine will be able to maintain analgesia

ns that are putatively unique to M. ulcerans but which, in fact, may exist in related mycobacteria in an environmental sample. In Phase
ed for speech tests. During the Phase I project several prototypes have been developed and evaluated. The preliminary data obtained in Ph
sing currently available synthetic chemistry approaches. Compounds altered by this approach simply become too expensive. The overall go
s essential.
(1 week) in the absence of clinically relevant toxicity in the rat model will constitute the milestones of this Phase 1 project. More than 50,0
e that will continue in Phase 3, in which we will clarify the potency, duration of action, and safety of the formulation in clinical trials. Apom
lubility and potent antagonist activity, effectively ameliorates bleomycin-induced lung fibrosis in mice. These results suggest that TGF-a ant
ful accomplishment of this Phase I project will result in the validation of 123 I-IMPY as an imaging biomarker for amyloid plaques in AD. De
ave now synthesized a highly potent and efficacious derivative of DTBZ, AV-133 for VMAT-2 binding. 18 F-AV-133 is a first of its kind F- 18 la
e size and complex structure of human nerves. Successful transfer of the graft preparation method will be determined by immunological a
5. Here we will perform the necessary genotoxic (chromosomal aberration AMES tests) and channel inhibition (hERG) studies. Finally, we wi
lestone review, the SET will also review plans for continuation activities. Overall, we believe that these studies will result in the developmen
data supporting the development of both biomarkers as tools to aid in the diagnosis of TBI are very compelling. In Phase II of this project a
on from which will be used to improve the new FIP assessment method prior to implementation of the Phase II system. Functional ability is
movement patterns. Assessment of GMs is a useful adjunct to the standard neurological examination, primitive refex profile, and assessme
out. A device, such as the KnowPain instrument, that offers an adaptive set of pain assessment questions will not only reduce the time inv

spores for sterilization processes using ethylene oxide, hydrogen peroxide gas plasma, and radiation. Sterilization is critical in a n

nt of software control that can rapidly reprogram the FPGAs to construct comparison pipelines optimized for different types of comparison
e to its competition and make it less costly to adopt. Colleges are experiencing increasing pressure to implement evidence-based interventi
Recovery are aware of any other web application that provides training in the SMART Recovery protocol. As a result, there is both a significa
sess the reliability of the HSI-Athat includes web-based administration and scoring features as an integral part of the commercialization pla
es; this project aims to develop innovative interactive online training in BA, in order to increase dissemination of evidence-based practices a
escents (PCT-A) is one efficacious approach for the treatment of panic in adolescents. The lack of effective treatment availability is compoun
assays for a family of proteins, called 'regulator of G-protein signaling' (RGS) that modulate the effects of GPCR ligands in a tissue-specific m
rate toward higher concentrations of signaling molecules that are released at the injury site. To enable the discovery of drugs to block this
RTD will be fully validated for high throughput screening and drug discovery by optimizing its integration with standard automated liquid d
cialize the identified biological mediators for the purpose of cell replacement therapy or stimulation of regeneration of endogenous pancre

ng with real-time force-position feedback. The unique design is ideally suited for older adults since the magnitude (intensity) of the target
that can be sold to laboratories involved in pharmaceutical and biomedical research. Each development milestone will culminate in validati

umber of cloned ene reductase enzymes by genome mining and directed evolution in Phase II continuation of this project, along with a dem
ical Trial with at least 300 patients to establish the reliability of this new instrument for rapidly distinguishing malignant from benign skin le
nd software to control the system. Feasibility will be demonstrated by performing multiple accurate, precise, and safe image-guided needle
fic Aim 3 will compare key elements of bioscience productivity and satisfaction identified during the evaluation period to existing support i
atients. These assays would use total nucleic acids isolated from blood, and a novel allele specific amplification technology with a reported
therefore we expect pWGA will have a fidelity of replication that is equivalent to MDA. Finally, the pWGA reaction appears much more rap
es for single and multiple sample processing, as well as for large-scale systems for biopharmaceutical manufacturing. The proposed researc
is frequently used to identify less common or unusual microbial pathogens. Most of these genera are also not currently included in Biolog
llel to these efforts, BIOMEC will apply for additional patent coverage, begin manufacturing scale-up, and identify the appropriate market c
ombined with anti-ischemic compounds OC-229 and/or EC-234, will: 1) have a meaningful protective physiopathologic response to hemorr
ged surfaces in the presence of profuse bleeding; b) its effects on clot formation; c) to determine if the addition of other thrombin and fibr
th researchers to visualize, analyze, and integrate information across space-time datasets for exposure assessment and environmental epid
ed and individual-level data including cancer vital events and measures of socioeconomic, demographic, behavioral and environmental con
es, residential history, cancer latency, time of diagnosis, and the exposure windows during which causative exposures are hypothesized to h
with this telemetric IOP sensing technology, physicians will be able to measure the effects that medications and life-style factors have on th

gineering techniques to improve the immunogenicity of the carrier even further. We will clone several peptide antigen sequences into the v
mmunoassays in both ELISA and lateral fow formats. Ultimately, our goal is to replace today's assays with a new generation of multi-peptid
or borne infectious disease in the United States and Europe, and its geographical range is expanding. One way to reduce the incidence of L

dition, we propose to carry out an exploratory study to screen a large number of coded archived clinical sera of different diagnoses in orde

OCT system for small animal imaging and other pre-clinical research applications. However, due to a limitation intrinsic to FDOCT, both of
as two distinct applications: quantitative measurement of HIV viral load in adults for disease monitoring; and qualitative infant diagnosis to
alth. Potential applications of the technology include the rapid development of engineered bacterial strains that either (a) abundantly prod
assemble a functional, simple, yet versatile azoreductase-based reporter gene system for expression in mammalian cells. New enzyme varia
and peri-ictal events cannot be made because of limitations in the required biomedical electronics.
y recordings from male and female adults and children to create limited acoustic inventories (adequate to generate a specific set of test se
ptomatic fare-ups with damage to the intestinal track. This could clearly improve quality of life and prevent the complication of surgery. St

hase II proposal to launch a professionally produced 40-episode health education serial radio drama with a companion web-based compon

nalysis, identification(s) should be feasible in less than 1.5 hours. Rapid response to infectious disease requires that the analytical proc
. IV. BioTex engineers will design and manufacture a device for sensor delivery, and complete study for sensor retrieval. V. BioTex scientists
o provide novel tools for directly screening caspase inhibitors or activators in live cells. These novel caspase substrates will greatly facilitate
t actually copy what the expert does, but will attempt to optimize the process based on cues that mayor may not be consciously monitore
l product for the target audience. The overall aim is to create a commercial version of the proposed device for persons with reduced visual
ock surgeries on foam bone models. The proposed work will validate computer-assisted techniques in total shoulder replacement. The pres

-life of sFlt-1. During Phase II, we will develop a cost effective manufacturing process and produce sufficient quantities of PEGylated recom
mponent for better resolution imaging of the human retina than ever before. This improvement in image quality will allow clinicians to det
d a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology ca
ace that will inhibit biofilm formation and encrustation on medical devices such as stents and indwelling catheters through: 1. Developing
e the safety issue of the anti-S. mutans STAMPs; and 3) The effective and safe anti-S. mutans STAMPs will be chosen to test their ability to

ce (SPR) systems] can lead to incorrect binding constants by orders-of-magnitude, most pharmaceutical companies have purchased SPR ins

Identify compounds that block or reverse the formation of protein aggregates utilizing an operational high content screen employing PC12
tested on primary neurons subjected to experimental degenerative stresses. The subsequent Phase II project will focus on the validation o

n be induced to create new cardiac myocytes, with specific emphasis on their fate when given as xenografted cells after experimental cardia
ctivity and release of drug from nanoparticles in a simulated physiologic environment. In addition, the effect PEG surface shielding and anti
g only monitoring. In addition, we anticipate that result from the proposed clinical outcome studies will provide physicians guidance to es
dualized, and cost-effective prevention programs addressing alcohol abuse among college students. The development, evaluation, and distr
eficits, which will be correlated with improvements in AD-like pathology. The goal of this proposal is to establish a strong, well-integrated r
cells in Specific Aim #2, and expansion of individual cell strains to numbers anticipated to be required for at least 3-10 patients in Specific A

m) system which can then be used as an alternative and effective salvage treatment option for prostate cancer. Once developed and tested
2 will lead to the development of NeuprosolTM which can then be used as an effective nerve-sparing agent during cryosurgical ablation of
o greatly stimulate the newly emerging fields of lysine acetylation and acetylation biology.

e scientific community to further its understanding of cellular changes leading to cancer.

velop a pooled phage library displaying peptides for 500 pharmaceutically relevant cytokines, growth factors, chemokines, and hormones, a
cer cells. Genetic screens with FV siRNA libraries have the potential to greatly simplify gene manipulation and discovery for many biomedic
dation of gene function and significantly impact the molecular dissection of human disease mechanisms. These reagents harbor considera
re consequence of gastrointestinal (GI) injury. Our unexpected finding that allogeneic, culture-derived myeloid progenitor cells protect aga

regions. If successfully developed, the entire sample preparation will take less than 30 minutes with 5-10 minute labor using only a magnet
m Kamp's lab has demonstrated that hESC-derived CMs are a functional surrogate for primary CMs and that the hERG channel blocker (e.g.,
system for spectroscopically identifying and verifying prescription medicines at the point of sale. This system will reduce the prescription d
handheld, multiplexed, lateral fow immunoassay system for cardiac biomarkers will be developed. Oxonica Inc will leverage its experience

ducers of macrolide resistance (e.g. MLSB) and these modifications are anticipated to enhance binding interactions and possibly infuence
fficking and to inhibition of repolarization of cardiomyocytes made from human embryonic stem cells, (ii) determination of effects on intrace
design of the solution used to perfuse the pancreas in the PTR will be optimized in four specific aims. The first step will be to use a system

mber of chemicals (>10,000) - much less chemical mixtures - that should now be screened for anti-EA by profit, non-profit, or governmental
prevent and arrest retinal NV. The Phase I project will determine the efficacy of these novel compounds on angiogenesis. Our in vitro stud
adults between 20 and 74 years, causing 12,000 to 24,000 new cases of blindness each year. Plasminogen kringle 5 (K5) is a proteolytic fr
ults, we hypothesize that Compound 4 is a promising drug candidate for the treatment of DME. The goal of this project is to develop a nov
o Phase II evaluations: 1. Using a novel antigen screening method developed by Chembio (termed MAPIA); the most seroreactive antigens
d to micro-scale systems that can be operated as portable instruments at the bedside. The proposed microfuidic confinement of each sens
on or decreasing fatty acid synthesis could become new urgently needed tools to combat the disease.
effective source of arsenic-free drinking water.
l allow appropriate preparation on the part of the obstetrician and the pregnant women to prevent the premature delivery.
ge part from the increasing awareness of key distinctive aspects of the care of the AABCP, wherein both biological and socio-cultural factors

expeditiously with FDA approval. The more limited goals of the Phase I (two years) are to develop an integrated prototype bioanalytical dia
ffector molecules. The goal is to create a T cell analysis system that offers high throughput screening, multi-parametric characterization cap

o capture quantitative speech features. An olfaction module will integrate a reliable, off the shelf system. The clinical base station will consi
rodent brain compared to DIV-BBB established with control (i.e., non-multiple drug resistant) blood-brain barrier endothelial and glial cells
enable all interactive tools and features, and test and finalize the website interface design. We will conduct a six-month randomized contr
ss suicidality are to: 1) Refine the content of modules 2-6. Using additional clinical sources, the detailed outlines appearing in Appendix 1 w
ents with schizophrenia. Treatment of cognitive deficits associated with schizophrenia represents an important clinical target for drug devel
crovascular amyloid, neuroinfammation and behavioral performance in these unique Tg-SwDI mice. Completion of these Phase 1 studies w
und that clinical and histological scores of IBD are less when the levels of small molecules known as polyamines are increased. To increase
o PD therapeutics represents a paradigm shift in the development of PD therapeutics. The goal of the proposed project entitled "Novel The
duced harmful infammatory responses, and reduced organ damage from clotting will lead to Phase II studies in baboons to evaluate effica
ndrocyte precursor cell death in a mixed culture of OPC and microglia. The completion of this Phase I grant will generate the preclinical dat
on of MAP kinase JNK, p38 and transcription factor NF-?B. The data generated by this proposal will enable us to select a lead candidate for
us, and pore diameter. The target characteristics are tailored to provide an environment for bone regrowth while maintaining strength duri
ttached to a syringe delivery device. 3) Establish that adequate bonding strength can be achieved using spray delivery system. The novel for
f our topical DC activators are found to be safe and effective in humans, they should enhance the efficacy of any vaccine that can be deliver
will also have the capability of presenting noise- degraded speech (e.g. background noise, and competing talkers), as well as speech training

leaching tests; develop enhanced membrane modules using commercial hollow fiber supports; building large skid for field testing and expa

T1) and facilitated glucose transporter (GLUT2) inhibitory activity and for compound uptake using mouse intestinal Brush Border Membran

evidence-based medicine in selecting CI candidates and following the outcome of cochlear implantation. It will also enable further research
ps requiring low power for their operation. The principal investigator of this proposal has recently developed a vacuum system in which the
en effectively applied in clinical practice, group interventions, and self-help books. The goal of Phase II is the final development and efficacy
are implementation and testing of the mPBE solver. Methods. Components from existing software will be reconfigured for mPBE-based calc
ompatibility. The current methods for closing ocular incisions, similar to other body tissue, require placing sutures to bring tissue edges in a

o confirm the predictions of the FEM. The purpose of this proposal is to create a less robust form of the device suitable for use in humans i

aningful change related to interventions designed to improve the health and functioning of older adults and to test the effectiveness of ne
stabilizers and the evaluation of the units with human subjects, including, once safety has been demonstrated, clients. It will also include t

sessions of FES-augmented NuStep exercise. Sessions will be managed and patients continually monitored by an Exercise Physiologist to ass

ors is the Neonatal Intensive Care Units. The inhaled nitric oxide therapy effectively decreases the need for extracorporeal membrane oxyg

utic proteins are produced annually from large-scale culture of recombinant cell lines producing a secreted protein. The number of biophar

a focal defect. The ultimate goal of this study is to develop a tissue engineering approach that can be used to resurface large segments of
ughput Screening system we propose represents a new approach to drug development. When successfully implemented, this High Through
ove the current therapeutic options available for the treatment and management of pain.
betes. In this way we will provide the groundwork for Phase II studies that will evaluate mechanism of action of these populations in m
fore incompletely folded in vitro have been forced to fold in the confined space of the reverse micelle. Despite these successful application
odule of STRIVE and film the video/DVD clips component for that module. A feasibility study will be conducted to determine the acceptabi
ase I period are to: 1) Conduct a focus group with drug abuse treatment professionals; 2) Research and develop the content for the facilitat
ed. We will also conduct feasibility evaluations of materials with a group of cosmetologists and a group of clinicians. In Phase II, we will dev
nd the intake process with telephone scripts; (4) conduct a review of the content with the Advisory Panel; and (5) conduct a feasibility stud

sychoeducational sessions; develop content for eight supplemental sessions; conduct an outcome evaluation of Youth LIB to determine cur
s in applying appropriate methods and the software tool to their studies.

year-old teens with CF with health information and social support opportunities. The program, called CFFONE: A Cell Phone Support Progr
roup; 4) Obtain appraisals of the educational value and appropriateness of the program by BPD researchers, clinicians, family advocates, an
ttitudes and intentions toward alcohol use. We will also examine the effectiveness of the gender-specific approach to alcohol prevention. D

home, significantly reducing excess patient disability and caregiver stress. COMMERCIAL POTENTIAL: A Market Feasibility Study identifies 6
tical in planning and evaluating needs for health, social, and commercial services. A substantial opportunity exists to provide data to both C
trasonic "chopper" technology (Phacoemulsifier for cataracts). The developed prototypes will be evaluated in the laboratory by a group of
d or incident-driven trainings; (4) a Web format familiar to young users; and (5) modifiability for a variety of campuses and campus settings.
e I and expand it to cover the full range of conceptual and procedural objectives, conduct a randomized clinical trial with dental profession

an aging community's shifts in resource consumption and availability could benefit from NEED-PLUS. Understanding individual communiti

novel biomarker discovery, assay generation, and validation. Specific Aim 1: Confirm that three pooled Random Peptide Phage Librarie
phage display portion of the DCP process. Together, specific Aims 1 and 2 will determine the optimal conditions for performing column ch

n rating scales. This innovation will ultimately equip the patient and care provider with information to better manage major depression.

efforts against these different receptor subfamilies. This grant is focused on developing an assay that can measure the activation of any gr

ed gene therapy for Fanconi anemia. Aim 2. Evaluate Sleeping Beauty transposon-mediated integration and long-term expression in human

be managed by the web- based system developed in Phase 2. Despite the best efforts of US industry, workers continue to lose their hearing
oughput chemical library screening and targeted cheminformatic approaches. The best hits will be evaluated against adult B. malayi and in
, automated array-microscope technology, represents a key development in advancing diagnostic and prognostic tissue-based digital-patho
g in automated design of more specific probes and primers that can be designed more quickly and more economically. ThermoBLAST will a
fore reduce the potential for unwanted and unnecessary radiation doses to the patient. It involves a colorless gel that can be exposed to th
The effort will build on our extensive experience in double-tuned MRI/NMR RF coils for small-animal studies and our extensive experience
bility to generate sustained rotating-frame frequencies above 140 kHz at the three resonances simultaneously, (2) static spectral resolution

ormance of the structure on high-quality CZT detectors. The Phase I work will reduce the risk for the successful completion of Phase II, whe

from the University of Cambridge. The assessment of cerebral autoregulation is of vital importance in many areas of clinical and investigati

e prototype biomedical products. As there is an increasing demand for directly diamond machining non-diamond machinable materials for
vide the most precise measurements of total body fat, lean mass, body fuids, and total body water of infants weighing from 1 to 11kg. Thi
utrophil elastase (HNE), a host infammatory protease present at high levels in chronic wounds. The first goal of this proposal is to alter the

containment units, which will increase the assay sensitivities by concentrating analytical samples. Relevance to public health: Contaminati
n a tissue culture model of infection. In this Phase I proposal, the activity of HG delivered on microbeads will be examined in feasibility stud
ple lines have been demonstrated to express the HisSLPI transcript. Work is in progress to see whether the plant-specific construct produce
These studies will use dimeric protein ?5-3-ketosteriod isomerase and human mitochondrial phosphoenolpyruvate carboxykinase. The for
adulthood. Low literacy has been associated with such poor adult outcomes as under- and unemployment, increased criminal activity, and
pore configuration can best be applied to improve on the state-of-the-art in laboratory ion channel measurements. This investigation will be
e (and that of generations to come), the company strongly believes that "hands-on" life science experiments for students ages 10 to 15 will
ueous phases. Field detection of trace levels of explosives has been demonstrated by EIC Laboratories. The two year Phase I program is des
blishing quantitative assay characteristics and coefficients of variation, and demonstrating optical imaging formats. Commercial EIC Laborat

bility of this package in the eyes of clinicians so that market demands for it would be optimized. Clinical usefulness depends on the reliabili
heir usual school environment. Health benefits include improved behavior modification based upon capability for accessing behaviors in a r
een characterized. The specific aims of this Phase I SBIR project are: (1) adapt hit clones to operate with eMetagen's improved cloning and e

perts, and through a small test of acceptability and knowledge gain in a sample of participants drawn from the target population. There is c
e prototype using California data; 3) assess usability and decision utility of the prototype through feedback from experts and end users; an
emphasis, loud and clear reply, tentative answer, sarcasm, and fast reply), synthesize 15 short phrases or words with each voice gesture, an
thetic breast tissue phantoms, and determine the sensitivity and specificity on excised human breast tissue specimens in a pilot clinical stu

anding of the fundamental cellular processes.

oscopy, bulk fuorescence, culture, real-time PCR, etc. Microfuidic circuitry will be designed and prototyped by Micronics using methods an
he United States and globally, contamination of drinking water by naturally occurring arsenic puts populations at risk of a variety of arsenic

hibit, adding representative drugs from each class of drugs of abuse to the VR tour, as well as adding traditional (real, non-VR) models and d
eactions, and IVIg therapy. In addition, the model could be used to address many basic questions in transfusion medicine dealing with com

measurements than Rint. APD can be used by young children, ill adults and in elderly patients. Phase I funding enabled us to considerably a
is also used for drug screening, production of antibody and production of therapeutic proteins. The main reason that rabbit has not been
successful completion of Phase I will also result in the identification of one or more lead compounds suitable for preclinical development in
tious disease. A further extension of the technology to peptide therapeutics will allow the efficient development of drugs to treat diseases
hanced by combining the gene therapy with standard chemotherapy treatments. Together, these studies will allow us to test the ability of o
ct as an efficacious, nontoxic topical treatment. Specific aims include (1) Optimal increased tear production with minimal adverse reactions
h as lung and ovarian. The expansion of the program to include splice variants from multiple genes and across two different cancers will un
V positive patient population worldwide is in excess 40 million. The vast majority of individuals living with this disease are in resource poor

ng Phase I). These research and development programs will lead to the development of a commercially available and fully functional Facto
different classes of biologically active chiral compounds with effective chiral modifiers, to explore the possibility of enhancing chiral resoluti
cs of a mini-GC coupled to an EBC collector. To that end, the following specific aims will be achieved: Specific Aim 1: Design and build a min
ggant(s) and taggant metabolite(s) in breath after oral ingestion of the taggant using the "gold standard" analytical technique, GC-MS. Spe
0 Atherosclerotic-Targeting Endohedrals (ATE): 1) Functionalize Gd3N@C80 with cholesterol moieties for enhanced uptake into macrophage

or cancer based on the identification of FAS which will broadly identify the presence of most human cancer.
nd safer energy production, and providing better understanding of the metabolic basis for medical conditions that will assist in the develop
ate path- ways leading to the biosynthesis of commercially important antibiotics with a focus on erythromycin.
e I UCB probe as a template. Precision will be improved by adding a second fuorophore to the UCB probe to create a fuorescence ratio pro
1. To determine whether or not ACT1 peptide promotes wound healing, and reduces infammation in diabetic C57BL/KsJ-m+/+Leptdb (db+
ed Molecular Evolution. Such technologies have commercial impact far beyond their development costs because they deliver a set of chem

patient attitudes toward using the speech translation system. The goals for Phase II are to demonstrate that speech translation technology
rostheses by growing cells that form new tissue on a biodegradable polymer scaffold. The goal of this Phase I SBIR application is improved
represents a significant step toward providing the research community tools not currently available to understand and improve the human
as well as for its newfound applications (hERG screening, transfecting/patching, and siRNA delivery) by integrating our platform with elect
nformation on the products, pricing, and funding sources will be available. For current clients, an e-commerce system will be established. E
ges. Implant the valve and test it both acutely and chronically on conscious, active normal IOP rabbits to determine safety and efficacy. Gla
g the gene perturbation in na ve cells to determine roles of their encoding products in the pathogenesis of HIV-1 and to evaluate their pote
ency and that of their collaborators at Case Western Reserve University is perfectly positioned 1) to design and optimize the circuit, printed
r (mAR), promotes cell death. Such potentially "competing" mechanisms could explain the discrepancy in the literature as to whether andr
elopment; and inhibitory activity at cytochrome P450 enzymes, which are involved in drug metabolism. With these data, we will be able to
software packages will be developed: (1) automatic high speed sensor operation and data collection software and ASIC, (2) backcalculation

to conduct a peer review of its model using experts in the field, including CSA Engineering in Mountain View, Calif., in order to verify scienti
and power are typically free variables. NASA's technology taxonomy has been developed by the SBIR-STTR program to disseminate awar
characterization to monitoring of environmental contaminants and in applications ranging from Toxicity Identification Evaluation (TIE) studi

nt while assisting our commercialization partners in preparing the technology/product/system for field demonstration The successful comp
anging from assessment characterization to monitoring of environmental contaminants and in applications ranging from Toxicity Identificati

nt while assisting our commercialization partners in preparing the technology/product/system for field demonstration The successful comp
ent, data validation and process accuracy will be assured through the collaborative participation of OC-ALC equipment specialist, planners,
id dynamic studies on critical areas are planned to quantify any potential for thrombus formation (stagnation) and red blood cell damage (

upport tools to increase performance of four key objectives: (1) monitoring for signs of pressure ulcers, (2) taking active steps to identify, m

iding seated comfort during work tasks in a variety of environmental settings. The backrest will improve user comfort, function, and postur
 scale to millions of compounds. The developed system will also integrate information on chemical compounds with biological activity and p
stical disclosure avoidance provided by the methods. 1 7 Project Narrative Many users of the Health and Retirement Study general-release
ing methods to produce a 128 x128 element 2D volume imaging array with a center frequency of 5MHz and ii) packaging the array, design
ential photoreceptor cell death in a primary mixed retinal culture system and to identify cytoprotective compounds to counter photorecept
oxicity (or lack thereof) in a small class of representative compounds will establish the predictive potential of our new system within the lim

ructures that incorporate information from Medicare/Medicaid administrative data sources into Census survey files; (6) formulate plans for
entially requirements; (5) complete plans for the creation of several ?standardized? research data structures processed from the raw CMS a
The conjugating kits include the hydrazide-dendron ligand functionalized nanoparticles and protocols for conjugation carbohydrate probes

) validate its performance in actual service with children users. To gain commercial acceptance, additional features such as passive holding

issociate the pancreas uniformly, and 3) the use of marbles to break apart the pancreas which results in physical damage at the cellular lev
is no effective treatment for the epsilon -toxin-mediated intoxication; therefore, a great need exists for the development of therapeutics a
inquiries from a wide range of researchers and clinicians interested in applying the AMP to investigations in sleep medicine, drug addiction
d dental sleep specialists to test patients for OSA and evaluate treatment efficacy. The Phase II project is designed to build upon the succes
r study focused on reducing morbidity and mortality from this challenging and harmful complication of dialysis.
tion, and DNA sequencing on its proprietary digital (droplet-based) microfuidic platform for clinical diagnostics. The proposed project aims

ncreasingly, media and tools that use to be accessed by wired home computers may now be accessed wirelessly by cell phones. What is mi

d scripted movement sequences. The phase II project will further develop the sensors and software, and conduct a human study.
erform wireless EMG data collection onto a miniature node. This device will support detailed human neurological studies, which support n

ntly available.
cation is focused on fully characterizing this Mabs library in order to identify the Mabs with the optimal characteristics to serve as develop
re will be applications in pre-clinical studies and drug trials, which will aim to invent novel treatment strategies using combinations of drug
approach. A subsequent Phase II application will lead to use of an appropriate platform for definitive marker validation trials for applicatio

widely used to manufacture adenoviral vector products, including Advantagene?s own late stage pipeline.

from 3x1010 to 3x1011 vector particles in half log increments, will be evaluated with 3-6 patients per dose. The study will be conducted b
sed breath analysis instrument will meet the need in the medical community for an instrument to allow the fast, noninvasive diagnosis and
competition so that the entire future of the MDI is not totally dependent upon one or two HFA propellants that could develop problems w
ecific aims in phase I are 1) determine reaction conditions for conversion of artemisinin to artemether under supercritical carbon dioxide, 2
obally disabled and are heavy users of healthcare resources. Current therapies have limited efficacy and issues with side effects. The presen
ep restriction in mice. Second, we will develop software that can automatically score sleep/wake state and control sleep deprivation proced
sition, and integrative analysis of cognition with other neurobehaviors. 3. Evaluate the capabilities and limitations of the SmartCage by perf
oach to enhance engraftment of skeletal muscle myoblasts (SMM) after injection into cardiac muscle. In Phase II, we plan to test an optimiz
we will characterize the anti-microbial activity and release kinetics of vancomycin bound and released from peptide coated metal. If succes
nal peptide coatings can improve the ability of a synthetic bone graft to promote bone healing by increasing the attachment and retention
addition of IFBM's that bind osteogenic growth factors, which are also present in bone marrow (Barnes, Kostenuik et al. 1999), to a second
ned baseline. This function will be vital to determine if the individual is suffering from any disease process limiting or exaggerating their ac
 ted by membranes loaded with the Perlecan D1 transgene delivery system vs. the sham-loaded membranes, and 3) to compare in vivo resp
pression construct, and to test the Perlecan D1 expression construct in guided tissue regeneration. Structural modeling has allowed rational
man systems and creating complete, ready-to-use learning activities that cover a semester-length course; 2) increase system usability by sim
on, recording and transport of the data are critical for the usability of the portable device. The project will use an innovative solution to the
who can benefit from this technology recruited through multiple speech clinics around the country. At the completion of Phase II, we will ha

h opioid analgesics, which solution will provide better management of addiction, treatment of acute and chronic pain, and relief from opio

s. These hydrogels will be tested to determine their swelling pressure, degradability, elastic properties and mechanical properties. Success
y; determine limits of detection and cross-reactivity for 12 individual pathogens in phosphate buffered saline and amended nasal swabs, la
amended clinical samples will lay the foundation for implementing Akonni's portable surveillance and diagnostic system for the rapid, trace
a scaled-up unit, which will include expanded sensor capabilities and adaptors for application to a larger number of commercially available
ll of the samples in the 24 well plate using a 24 element CMOS APD detector. The goal of the Phase II program will be to build a fully integra
n of multiple proteins in a single unit. RMD proposes to develop a compact disposable sensor that will rapidly detect biomarkers for tr
and proven by RMD. After fabrication, the films will be characterized in detail in terms of their morphology, scintillation properties, optical p
on the order of millimeter in size it is important parameter. Third, thin layers will have small cross-section for gamma absorption, reducing
ncerous tumors. In addition, to advance the sensitivity of existing DOT instruments and take advantage of this new family of dyes, improve
develop technology that can be used to test consumer products for lead content. The result will be a very inexpensive, safe, and easy to use

r crystallography, which compliments x-ray crystallography in its ability to precisely locate hydrogen atoms in protein molecules. The inform
e NIH's data sharing policy by making our software free (with source code) to organizations who make their data free too. We, as do many o

o-Jade B labeling of degenerating cells and cell birth via examination of labeling of neural progenitor/stem cell proliferation and (2) whethe

d rule-based system has been developed (BI- RADS) for reporting, describing and scoring the Level of Suspicion (LOS) for cancer based on th
e to an increase in incidence and resistance to conventional chemotherapeutics and external beam radiation. In spite of recent advances in
ucts in therapies that are showing promise in cancer therapies. NIH funded researchers have been obtaining promising results using molec
es. Great achievements have been made in understanding the genetic code of disease. However the next great opportunities for infue
mproved treatments. We have developed a novel, low-cost, high throughput approach for proteomics based on Bead Sorted Libraries of In V
g samples to AmberGen for validating the MASSIVE-PRO assay. Quest Diagnostics will also advise on assay development to ensure compati
al samples including prospective samples obtained from pre-operative CRC patients in collaboration with Dr. Paul Schroy, Director of Clinica
and in some cases superior to standard DNA sequencing. During Phase II, we will further develop and extensively evaluate these novel NF1
h samples with corresponding frozen tissue controls to determine which sample offers the best combination of sensitivity and robustness.
neous detection of major mutations in patients with AML and CML/MPDs. 2) Develop comprehensive controls for the clinical evaluation of

han conventional detergents at promoting the native-like stability and functionality of solubilized GPCRs, providing the basis for breakthrou
ompts will encourage hand washing and hand sterilization in hospitals. It will affect public health by reducing the chance of a patient acqui

om this study will be submitted to in- depth, preclinical SBIR Phase II studies (oral and delayed efficacy, preclinical models of ALF combining
protective effects of Refanalin against ischemia-induced apoptosis/necrosis in lung transplantation in an animal model. Lung transplantatio
7. In a preliminary in vivo lung tumor study it showed anti-tumor activity with a trend toward improved, but not statistically significant, acti
xplore the possibility of developing Ang1170 as a new therapeutic approach for the treatment of Scleroderma. Dermal Fibrosis or Sclerode
educes tissue damage. Our preliminary data show that Ang797 and its analogs act as specific inhibitors of Met and Tie2 kinase cascade pat
neurological recovery and preserves neuronal and grey matter integrity. Importantly, in a well-described and clinically relevant model of S

to determine if the host immune system enhances tumor kill by the bacteria. The specific aims are as follows: (1) Select additional multiple

on the UBL expression system could also be of significant value to the biomedical research community. To develop this system and demonst
tion ages. Unfortunately, there is no simple means for early detection. A diagnostic for early AMD could aid in the development of early-sta
3 monotherapy (as a positive control) vs. vehicle alone (as a negative control)-in tape stripped and irritant contact mouse models. Use of b

n of something more ominous. The proposed research will lead to such a device.
on. Additionally, we will determine the optimal schedule for treatment of the animals in the eye disease models. Finally, FDA-required stud
us of this proposal is to develop proof-of-principle for an effective, clinically applicable approach to induce immune tolerance to xenogene
rm of core streptavidin, modification of the cell membrane with biotin, and decoration with chimeric proteins. There are three distinct adva
ead commercial product to test in a Phase I clinical trial. In addition, ApoVax104 vaccines may not only protect against cancer but also again

ware and relational database. Specific Aim III: The instrument will be evaluated for performance in imaging of challenging protein crystals i
ncy will be evaluated during 4 simulated scenarios. Results will be compared between those who have received the web-based course and
performance of the clinicians both with the display and without. In addition, we will use a series of subjective instruments to ascertain info
reversal of opioid effect to restore spontaneous ventilation, and more rapid wakeup at the end of surgery. By generalizing the PkPd model

couple novel automated vector identification and remote activity instrumentation to standard adult mosquito monitoring technology for m
a about the biological effects of the environment on animals. In addition, analysis using microarrays is generally considerably less expensive
able proof-of-concept drug uptake and distribution studies in rats. 2. Develop methods to test the performance of the stents 3. Conduct in

ults proving feasibility: (1) the compact long-term storage and dispensing container maintains precious liquid in an evaporation and contam
e of the proposed system is two-fold. First, the developed knowledge base can be used as a highly integrated cross-domain knowledge reso
velop cell culture processes to provide sufficient quantities of a mAb to perform preclinical testing in animal models and to determine whe
am processing of the fusion protein. Fusion proteins comprised of BBB targeting antibodies and recombinant enzymes could be therapeuti

rocedures by making them safer and more comfortable.

udy the company proposes to explore the specific use of CD 133 hemangioblast as a cell type to rescue retinal vessel obliteration and dimin

racy of the system.

g memory loss and degradation of other cognitive functions. Nocturnal hypoglycemia is particularly troublesome for many individuals with

ion criteria and clinical endpoints for Phase I and Phase II clinical development (as per discussion with FDA). Aim 4: Characterize stem cell h
will be able to maintain analgesia in rodents for a prolonged period of time (3-5 days) following a single subcutaneous injection. Such a form

ronmental sample. In Phase I, we plan to develop the VEL-PCR method and test it on environmental samples inoculated with M. ulcera
preliminary data obtained in Phase I indicates that the current design has a significantly reduced occlusion effect, good ambient noise excl
me too expensive. The overall goal of the project outlined in this proposal is to use a novel Chemo-Enzymatic Synthesis (CES) approach to id

Phase 1 project. More than 50,000 transplants requiring immunosupression are performed annually and the market for immunosuppressi
rmulation in clinical trials. Apomorphine was approved in 2004 for the treatment of Parkinson's disease. The benefit of this treatment is lim
se results suggest that TGF-a antagonism may be a viable therapeutic strategy. In this proposal there are two specific aims: 1) to generate h
er for amyloid plaques in AD. Development of such a product will represent a significant technological and scientific innovation that will all
V-133 is a first of its kind F- 18 labeled VMAT-2 targeting radiotracer that will be utilized to in a proof of concept clinical trial to image BCM
determined by immunological analysis and histological analysis verifying (i) structural preservation of the graft and (ii) cellular removal and
on (hERG) studies. Finally, we will develop methods for large-scale chiral synthesis of AK295, and other ketoamides, that will be needed for
dies will result in the development of an improved bladder cancer therapeutic and contribute to our understanding of the BCG-host interac
lling. In Phase II of this project a commercializable ELISA assay kit for both biomarkers (BA0123 and BA0252) will be developed. Assay comp
ase II system. Functional ability is a crucial component of the assessment of any chronic pain condition. Although considerable attention ha
itive refex profile, and assessment of muscle strength and tone. However, use of video recording is not ideal since it is tedious, subjective,
will not only reduce the time involved with current pain assessment methodologies, but also provide more accurate results and be more ap

Sterilization is critical in a number of industries, from healthcare and pharmaceuticals to fermentation and food service. Conventiona

or different types of comparison (BLASTN, BLASTP, etc). At the end of this phase, the combined hardware and software of the smart disk pro
ement evidence-based intervention programs to reduce heavy drinking and alcohol-related problems in their student body (NIAAA, 2002a,
s a result, there is both a significant commercial opportunity in developing an effective web application and a public health benefit potentia
part of the commercialization plan. The HSI-A will be marketed through a commercialization plan and will provide a screening tool for early
on of evidence-based practices and improve clinical outcomes for adults suffering from depression.
reatment availability is compounded by inherent difficulties in providing clinicians with training in treatments like PCT-A, beyond written te
PCR ligands in a tissue-specific manner.
discovery of drugs to block this process, we are developing plastic devices for high throughput cell migration assays in defined chemical gra
ith standard automated liquid dispensing equipment. Cellular assays that are more predictive are greatly needed in the pharmaceutical ind
eneration of endogenous pancreatic a cell progenitors to treat type 1 diabetes.

gnitude (intensity) of the target trajectory for the VLC phase can be programmed to be significantly elevated with respect to the VSC phase
ilestone will culminate in validation experiments, to be accomplished by comparing data acquired using the new technique with data eithe

n of this project, along with a demonstration of the practical use of ene reductases in the synthesis of otherwise difficult to synthesize phar
ng malignant from benign skin lesions. We will also compare the electric field near melanomas as measured with the BFI to that measured
se, and safe image-guided needle biopsies on breast phantoms in a 4 tesla (T) MRI scanner at the University of Minnesota's Center for Mag
ation period to existing support in the LabmatrixTM early prototype, and will document new requirements. Phase I, Specific Aim 4a will evo
tion technology with a reported specificity of 10-7. This extraordinary specificity is possible because oligonucleotides with a 3' dideoxy term
reaction appears much more rapid than MDA. Whole genome amplification technologies are a useful tool for cancer research and genetic r
ufacturing. The proposed research is expected to produce technology and devices which will provide significant benefits to public health. T
not currently included in Biolog's Identification Database. However, with success in development efforts proposed here, the Database will
dentify the appropriate market channels. The markets for this device include both the civilian emergency response teams (EMTs and ER sta
opathologic response to hemorrhage/hypovolemia by improving the end points of mean arterial pressure, arterial blood gases and liver fu
ition of other thrombin and fibrin like agents and P-selectin-immunoglobulin chimera -that specifically stimulate P-selectin, will enhance cl
essment and environmental epidemiology. This software will enable exposure scientists to generate exposure estimates incorporating temp
havioral and environmental conditions. The methods developed in this project will help understanding the causes underlying the disparitie
 exposures are hypothesized to have occurred. To our knowledge the techniques and software from this project will be the first to address a
and life-style factors have on the IOP of their patients in a real- time and continuous model.

tide antigen sequences into the vector and express and purify the peptide-immunogen fusions from bacteria. We will then produce polyclo
new generation of multi-peptide based tests. Because of greater specificity and the improvement of sensitivity that we can achieve, this a
way to reduce the incidence of Lyme disease is to eliminate B. burgdorferi from its reservoir and/or from the ticks that feed on them, break

ra of different diagnoses in order to investigate whether there are certain infammatory diseases with elevated soluble TL1A. Undoubtedly,

ation intrinsic to FDOCT, both of these systems are limited in imaging depth to less than 4 millimeters, which is insufficient for full-depth an
nd qualitative infant diagnosis to determine the presence or absence of HIV infection in infants below 15 months of age. Both diagnostic as
s that either (a) abundantly produce pharmaceutically important natural products, available only in limited quantities from natural hosts or
mmalian cells. New enzyme variants and pro-fuorescent substrates we will be combined with existing reporter technology for extended ve

generate a specific set of test sentences) and VT training recordings. Perceptual experiments will be conducted to evaluate voice quality an
t the complication of surgery. Studies that characterize microfora in humans using powerful techniques from environmental microbiology

companion web-based component. Our health education focus has broadened to address the particular health burdens experienced by A

requires that the analytical procedures employed are inherently fast. Compared to most analytical techniques, mass spectrometry is gener
sor retrieval. V. BioTex scientists will collaborate with endocrinologist Dr. Eric Orzceck, MD, in order to guide us towards a feasible sensor de
substrates will greatly facilitate our understanding of apoptosis and its relation to various diseases and the development of future therape
may not be consciously monitored by the expert. The Specific Aims of the Phase I component will be to: (1) integrate recording capabilities i
for persons with reduced visual acuity, reduced contrast sensitivity, or other loss of visual function caused by macular degeneration, diabe
shoulder replacement. The presented technology will allow surgeons to accurately plan and execute implantation of the prosthetic should

nt quantities of PEGylated recombinant sFlt-1 for testing in animal disease models of RA. Rheumatoid arthritis (RA) is a chronic infammator
quality will allow clinicians to detect and diagnose diabetic retinopathy and macular degeneration as well as to determine the efficacy of dr
ered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE.
atheters through: 1. Developing techniques for depositing these films on urinary devices such as ureteral stents, Foley catheters, and ureter
be chosen to test their ability to convert the "diseased plaque" to "healthy plaque", using the established in vitro, ex vivo and in vivo assays

mpanies have purchased SPR instruments. With Caldera's proposed innovation, researchers will have a major technological advantage, for

h content screen employing PC12 cells expressing G85R mutant SOD1-YFP and in which protein aggregation can be directly observed and qu
ect will focus on the validation of actives in one or more animal models of PD, chemical optimization as needed and translational studies (c

ed cells after experimental cardiac injury. Results of the proposed Phase II STTR studies will be pivotal to the commercial development of th
ct PEG surface shielding and antibody targeting ligands have on both nanoparticle uptake by macrophages (for clearance) and B-cell killing (
provide physicians guidance to establish threshold SctO2 values for various clinical situations.
velopment, evaluation, and distribution of the BASICS DVDs will encourage broader dissemination of this Best Practice program among coll
ablish a strong, well-integrated research program based on recently established roles of Th1/Th2 immunity, HUCBC transplantation, and AD
t least 3-10 patients in Specific Aim #3. These results would provide the basis for follow-on Phase II SBIR studies designed to assess produc

ncer. Once developed and tested, the system may become useful as an alternative treatment for prostate cancer as well as an alternative m
t during cryosurgical ablation of prostate cancer. Once developed and tested, NeuprosolTM may become useful as a nerve-sparing treatme

rs, chemokines, and hormones, as well as technology for HTS of biologically active phage displayed peptides in a cell-based assay. In collabo
and discovery for many biomedical applications, such as validation of gene function, probing interactions between genes, and the establish
These reagents harbor considerable promise to identify new targets for therapeutic intervention, and the development of increasingly relev
loid progenitor cells protect against radiation-induced GI injury will have a significant positive impact on the survival and quality of life of th

minute labor using only a magnet. With this sample preparation method, it should be possible to perform a real-time PCR viral load test with
t the hERG channel blocker (e.g., E-4031) produced a prolongation of action potential recorded from such cells. CDI's combined expertise in
em will reduce the prescription dispensing errors at pharmacies. Currently dispensing errors are a problem on a national level, at a rate of a
Inc will leverage its experience in SERS nanotag manufacture and assay development with Centice's expertise in novel Raman spectromete

eractions and possibly infuence macrolactone rigidity. Fifty prototype A and 50 prototype B analogs will be generated and specifically scree
etermination of effects on intracellular calcium ion transients in animal cardiomyocytes, because this is known to be correlated with cardiac
first step will be to use a system of high throughput assays to select cytoprotective additives to be incorporated into the base perfusates. T

ofit, non-profit, or governmental entities. Development of a robotic assay for anti-EA is desired as part of the mission of NIEHS, EPA and ICC
n angiogenesis. Our in vitro studies will evaluate whether these new compounds have anti-angiogenic activity. We will also determine the e
n kringle 5 (K5) is a proteolytic fragment of plasminogen. It is an endogenous angiogenic inhibitor. Plasminogen contains 5 kringle domains,
f this project is to develop a novel, more effective, less toxic thalidomide analog for clinical trials to treat DR and commercialization. In this
the most seroreactive antigens recognized during the acute phase of leptospirosis will be identified. 2. A combination of the most serorea
fuidic confinement of each sensor will eliminate sensor cross-talk and will increase sensitivity by confining enzyme products to small volum

emature delivery.
logical and socio-cultural factors impinge on our ability to furnish optimal care to a deserving population. This effort will produce a comput

ated prototype bioanalytical diagnostic platform consisting of an instrument and reagent cartridge and to develop and validate a chip desig
-parametric characterization capability and incorporates state-of- the-art integrated sample handling for ease-of-use. At present, there are

he clinical base station will consist of a small, lightweight laptop computer with an integrated radio and clinical interface software. The bas
barrier endothelial and glial cells. 2) To compare the permeability value of antiepileptic drugs measured directly in serum and brain of pharm
ct a six-month randomized controlled evaluation with informal dementia caregivers to measure the impact of the website on knowledge, se
tlines appearing in Appendix 1 will be further refined; 2) Create modules 2-6. CME Development Group will use the clinical content refined
tant clinical target for drug development that has not been addressed by the pharmaceutical industry. The studies outlined in the proposal
etion of these Phase 1 studies will provide proof of principle that a novel drug treatment may reduce cerebral microvascular amyloid-induc
mines are increased. To increase polyamine levels, one needs to increase the amount of arginine, an amino acid derived from our diets, tha
osed project entitled "Novel Therapy for Parkinson's Disease" is to evaluate a novel approach to treatment of a debilitating disease that pre
ies in baboons to evaluate efficacy in a primate model that was used for development of the only FDA approved therapeutic for treatment
will generate the preclinical data to establish the utility of our COG compound as a unique, remyelinating agent for the demyelinating dise
us to select a lead candidate for the treatment of MS. After the project is completed, this lead will be progressed through the safety pharm
while maintaining strength during healing. During Phase II of the project, the bone adhesive will be tested in vivo to demonstrate efficacy
ay delivery system. The novel formulation will be tested with the novel delivery device to establish that the product performs adequately w
of any vaccine that can be delivered into the skin. The best public health response to pandemic infuenza is an effective vaccine, but with cu
alkers), as well as speech training using phrases, sentences, and passages in careful and casual speaking styles. The final system will be used

rge skid for field testing and expanding our economic evaluation to show superior performance to alternative drying routes. Throughout th

ntestinal Brush Border Membrane Vesicles (BBMVS). 3. To determine the effects of the lead compounds on blood glucose and glucose toler

will also enable further research into the functional abilities of CI patients and facilitate further improvement in CI technology. Individual C
ed a vacuum system in which the room air can be introduced in the form of short pulses lasting approximately 100 ms without increasing th
e final development and efficacy testing of the PSMP, which will consist of seven modules, including Program Overview, Understanding Chr
econfigured for mPBE-based calculations. The main component is an adaptive Cartesian grid, which combines a hierarchical, octree decom
utures to bring tissue edges in apposition. The presence of sutures in the cornea leads to patient discomfort, visual distortions, risk for bac

vice suitable for use in humans in Phase II. Critical features of this proposal are the use of finite element modeling to determine optimal dim

nd to test the effectiveness of new clinical treatments and interventions. The product of this STTR project will be a marketable Computer Ad
ated, clients. It will also include the design, development and evaluation of the arm and base components as well as their integration with

by an Exercise Physiologist to assure their safety. Feasibility will be defined as the ability for the adaptive stimulator to develop client-specifi

r extracorporeal membrane oxygenation treatment. Since prolonged exposure to inhaled nitric oxide poses high risks for elevated methem

protein. The number of biopharmaceuticals in clinical development and being FDA approved each year is growing dramatically, resulting in

d to resurface large segments of the joint that have been affected by degenerative diseases such as osteoarthritis.
implemented, this High Throughput Screen can be used to identify drugs that will help in the immune destruction of viruses and tumors, w

action of these populations in more detail and develop methods by which these cells can be harvested and delivered in a therapeutically e
pite these successful applications, the method has not been generally adopted by the NMR community. The reasons for this are clear: The
cted to determine the acceptability and effectiveness of the module. STRIVE will be the only comprehensive training resource to assist ado
velop the content for the facilitator's guide and participant workbook; 3) Conduct a review of the developed content with an expert Adviso
linicians. In Phase II, we will develop additional materials, including a TTM Intervention Manual for Clinicians, a Clinician Online Course, a C
and (5) conduct a feasibility study of the one programmed module with mental health clinic staff and trainees. Given the high rates of unde

on of Youth LIB to determine curriculum efficacy; and finalize the curriculum based on the results of the pilot evaluation. Given the shortag
ONE: A Cell Phone Support Program for Teens with Cystic Fibrosis, will make use of cutting-edge technology-a broadband capable, cellular t
s, clinicians, family advocates, and family members who have a relative with BPD. The 2006 Omnibus Solicitation for SBIR and STTR Grant A
pproach to alcohol prevention. Despite recommendations from substance abuse prevention and curriculum development experts, none of

rket Feasibility Study identifies 6,329,754 total institutional and/or individual buyers including, among others, the following market segme
y exists to provide data to both Chinese and United States agencies and companies that seek to serve the Chinese market. Current informati
d in the laboratory by a group of periodontal surgical consultants who currently use MIS or who are leading, published, periodontal surgeon
campuses and campus settings. The project will survey 123 national fraternities and sororities and use their suggestions, focus group data
nical trial with dental professionals comparing the web-based training program to current "usual care" curricula, develop final versions of t

erstanding individual communities and how they change with age is an essential aspect of keeping those communities healthy. Creation of

Random Peptide Phage Libraries actually contain binding phage species against each of the five diabetes antigens chosen. Specific Aim 2:
ditions for performing column chromatography of filamentous phage, leading to the selection of phage peptides that bind specifically to mo

er manage major depression.

measure the activation of any growth factor receptor in the Human Genome. This technology will allow for the discovery of novel small mo

d long-term expression in human CD34+ hematopoietic stem cells. For both of these Aims, SB transposon DNA and transposase-encoding s

rs continue to lose their hearing; the current state-of-the-art in occupational hearing conservation is based on a failed paradigm that includ
ed against adult B. malayi and in vitro and assayed for mammalian cytotoxicity and microsomal stability. Finally, the most promising compo
nostic tissue-based digital-pathology analysis. The result of this combination will be a less costly, fast and highly accurate microscopic imag
conomically. ThermoBLAST will allow scientists to develop better assays, while saving time and money, and thus will positively impact the q
ess gel that can be exposed to the planned radiation; the gel develops color, showing the pattern of radiation dose actually delivered.
es and our extensive experience in cryogenic NMR rf coils. During the Phase II, two second-generation (40 K) platforms for H/13C at 7 T and
usly, (2) static spectral resolution below 0.03 ppm, and (3) S/N on 15N better than 50:1 on 70 fL of natural-abundance formamide. Achievin

sful completion of Phase II, where we will construct the detector module prototype which will consist of individual detector modules (tiles

ny areas of clinical and investigative medicine. Therefore, in Phase II we plan to incorporate the MMPF software into existing transcranial Do

amond machinable materials for a wide variety of biomedical and other applications, this proposed technology provides a new solution for
nts weighing from 1 to 11kg. This weight range should be enough for infants up to 12 months, as the weight of a 12-month- old reference b
al of this proposal is to alter the amino acid sequence of the target peptide to reduce interference by HNE while maintaining sensitivity tow

ce to public health: Contamination of food and feed by mycotoxin-producing fungi is one of the most important health-related problems in
ll be examined in feasibility studies for the final treatment formulation in Phase II. This formulation will consist of HG peptide incorporated
plant-specific construct produces the correct SLPI protein that is biologically active. In Phase I, the HisSLPI construct will be modified to tar
lpyruvate carboxykinase. The former is a well characterized and crystallized protein; the latter is not. In the second aim, we will assess the e
, increased criminal activity, and poverty. The empirically validated IM products that will result from this project will address the potentially
 ements. This investigation will be conducted with Dr. Henry White from the University of Utah, whose lab helped develop the glass nanopo
ts for students ages 10 to 15 will play a significant role in developing interest and comprehension of science, with direct impact on our soci
two year Phase I program is designed to expand the pesticides studied, demonstrate detection to CDC listed limits, show an adequate usab
ormats. Commercial EIC Laboratories will commercialize the technology by manufacturing and direct sales of the arrays as blanks and with

efulness depends on the reliability of a technique not just at a single selected time point along the evolution of infarct, but rather at all rele
lity for accessing behaviors in a real school environment for immediate or later review. Cost benefits include reduced time for caregivers to
Metagen's improved cloning and expression system and re-confirm their antibiotic activities, (2) prioritize hit clones according to indicators o

the target population. There is currently a strong policy focus on improving prevention effectiveness by providing tools that will help practi
k from experts and end users; and 4) assess feasibility and implications for Phase II. There is currently a strong policy focus on utilizing alcoh
ords with each voice gesture, and evaluate the ease of use of the icons and the appropriateness of the synthesis. These varieties of voice g
e specimens in a pilot clinical study. Concurrent with this effort, we are recruiting expertise in management, regulatory and reimbursement

d by Micronics using methods and tools previously developed for production of similar microfuidic cards employing nucleic acid and immu
ons at risk of a variety of arsenic-related diseases. The proposed Phase II program will provide a cost- effective and highly accurate way to m

onal (real, non-VR) models and displays to the exhibit. This project will address the National Institute on Drug Abuse's objective that all me
usion medicine dealing with composition and assembly of the erythrocyte Rh complex, immune tolerance, and immunosuppression. The pr

ing enabled us to considerably advance APD to its current configuration. Pre-Phase I APD weight/cost were 10 pounds/$3,500. APD is now
reason that rabbit has not been in these fields is that there have been no established germline competent rabbit embryonic stem (rbES) ce
ble for preclinical development in Phase II for adjunctive therapy for MI patients undergoing fibrinolytic therapy. This project proposes that
pment of drugs to treat diseases that are not currently amenable to antibody based approaches.
will allow us to test the ability of our polymeric vector formulated with IL-12 plasmid to control the growth and progression of malignant bra
n with minimal adverse reactions after topical administration in an in vivo rabbit dry eye model, (2) Determination of basic parameters of la
oss two different cancers will undoubtedly demonstrate the broad-based application of Epitome's technology for splice variant detection. T
his disease are in resource poor environments where conventional CD4 enumeration is both too expensive to perform and technically chal

ailable and fully functional Factor VIII protein that has significantly reduced immunogenicity as confirmed in HLA transgenic mice and Facto
bility of enhancing chiral resolution using multiple gas phase interaction forces between chiral modifier and enantiomeric ions, to analyze a
fic Aim 1: Design and build a mini-GC device coupled to an EBC collector with active breath management that reliably measures ethanol co
nalytical technique, GC-MS. Specific Aim 3: Design and build a mGC device to reliably measure in real-time the gas phase concentration of
nhanced uptake into macrophage foam cells, 2) Develop formulations for "active" and "passive" Gd3N@C80-cholesterol molecules, 3) Char

ns that will assist in the development of new cures. For some promising new natural products, our technology could make the difference b

o create a fuorescence ratio probe. Probe stability will be increased by altering the fuorophore-FABP conjugation chemistry. The third aim
etic C57BL/KsJ-m+/+Leptdb (db+/db+) mice. 2. To determine if topically applied ACT1 peptide on skin wounds in diabetic C57BL/KsJ-m+/+Le
ecause they deliver a set of chemical performance specifications that is unavailable by existing chemistry. The proposed work will develop a

at speech translation technology can be more accurate than ad hoc interpreters and as accurate as trained interpreters when used for spec
se I SBIR application is improved techniques to test the laboratory grown tissues before they are implanted, resulting in prostheses that per
derstand and improve the human health condition. Through the use of a single chemically inert tag, important biomolecules such as peptid
egrating our platform with electrophysiology capabilities as well as improving its throughput and lowering its required reagent volumes.
erce system will be established. E-training modules on all aspects of administration, data interpretation, intervention planning, and evaluati
etermine safety and efficacy. Glaucoma, a wide spread ocular disease increases the pressure inside the eye and if left untreated causes blin
HIV-1 and to evaluate their potential as therapeutic targets. New drug candidates against HIV-1 infection based on these host targets will t
and optimize the circuit, printed circuit board, and selection of sourcing components and external prototyping firms, 2) to test a complete
he literature as to whether androgens are protective or promote cell dysfunction and death. Importantly, these data serve as the basis for
ith these data, we will be able to accept or reject a compound for the next Specific Aim, which is the preclinical tests predictive of antidepr
ware and ASIC, (2) backcalculation and runway load bearing capacity estimation equations and data analysis software to get a 3-D runway d

ew, Calif., in order to verify scientific principles and conduct a further detailed business case analysis for the eddy current brake.
TR program to disseminate awareness of proposed and awarded R/R&D in the agency. It is a listing of over 100 technologies, sorted into br
 ntification Evaluation (TIE) studies to new chemical registration to Whole Effluent Toxicity (WET) testing.

monstration The successful completion of this proposed Phase II project will produce a commercially viable true green process for water co
ranging from Toxicity Identification Evaluation (TIE) studies to new chemical registration to Whole Effluent Toxicity (WET) testing.

monstration The successful completion of this proposed Phase II project will produce a commercially viable “true” green process for water
equipment specialist, planners, and shop foor supervisors. When completed; the system, captured data and supported processes will be
on) and red blood cell damage (high shear regions). Finally, in vivo animal experiments are planned to verify both hemocompatibility and

taking active steps to identify, monitor, and mitigate risk factors, (3) managing pressure ulcers using current standard practices, and (4) sup

er comfort, function, and posture during multiple activities of daily living.

 nds with biological activity and protein interaction networks, thus enabling more efficient drug discovery.
etirement Study general-release data ?les would benefit from some access to the restricted-release ?les without the requirement for specia
d ii) packaging the array, design and fabrication of the bias hardware and control circuitry and an iii) internal clinical study to evaluate perfo
mpounds to counter photoreceptor cell death caused by light stress. 2) Utilize A2E in combination with light stress to induce cell death in a r
of our new system within the limited scope of the Phase I proof-of-concept project, and will set the stage for a larger Phase II demonstratio

rvey files; (6) formulate plans for extensive data documentation to make constructed variables easily understood and retrievable by researc
s processed from the raw CMS administrative files, formulated to integrate information across several administrative sources and to meet t
onjugation carbohydrate probes. The glyconanoparticles prepared with this technology will have 3D polyvalent carbohydrate display, with

eatures such as passive holding capacity and improved cosmesis will be incorporated. ADA will work with practicing prosthetists in the Shr

ysical damage at the cellular level. Advanced Biological Technologies, in collaboration with the University of Cincinnati, is developing a pro
e development of therapeutics against this biodefense toxin.
n sleep medicine, drug addiction, pharmaceutical evaluation, forensic investigations, ergonomics, sports medicine, military applications, ed
esigned to build upon the success achieved during Phase I in working with the dental community to provide a comprehensive program that

stics. The proposed project aims at demonstrating the feasibility of performing newborn screening for lysosomal storage disorders includin

essly by cell phones. What is missing is a mechanism for patients to use their medical devices with their cell phones as they did with their

onduct a human study.

ological studies, which support numerous research areas including, but not limited to, ataxia, dystonia, and Parkinson's disease.

aracteristics to serve as development candidates. The Specific Aims are: 1. Characterize the binding kinetics and specificity of anti-GP88 Ma
gies using combinations of drugs that block 'growth factor' molecules.
ker validation trials for application to clinical screening of NSCLC. Thus the primary goal of this application is to develop a novel blood test fo

e. The study will be conducted by Advantagene, which has a track record of efficient translation of laboratory studies into clinical gene the
e fast, noninvasive diagnosis and monitoring of patients with lung disease. It will also be a powerful research tool for investigating exposur
s that could develop problems with availability, affordability, long term toxicity, and/or environmental impacts. The overall mission of Aerop
er supercritical carbon dioxide, 2) determine supercritical carbon dioxide conditions for isolation of artemether product, and 3) demonstra
ues with side effects. The present project proposes a method to significantly reduce drug discovery and early development risk by triaging
control sleep deprivation procedures based on EEG/EMG or piezo signals. Third, we will evaluate and validate DiscTreadmill efficacy and lim
tations of the SmartCage by performing feasibility tests on the prototype, and benchmark tests against the original touchscreen apparatus
ase II, we plan to test an optimized mixture of Affinergy peptides for therapeutic cell engraftment and functional tissue repair in animal mo
m peptide coated metal. If successful, Phase II work would involve biopanning of two more antibiotics targets (an aminoglycoside and a tetr
ng the attachment and retention of osteogenic growth factors and cells. First, using phage display techniques, we will identify tricalcium ph
ostenuik et al. 1999), to a second generation bone marrow filtration device. This second generation device is envisioned to select and conc
limiting or exaggerating their activity. This function will be particularly useful in studying and identifying behavioral disorders such as depre
 s, and 3) to compare in vivo responses generated by placement of the loaded vs. the sham-loaded surgical membranes in an animal mode
al modeling has allowed rational design for site-directed mutagenesis of the Perlecan D1 core sequence to increase glycosylation and enha
increase system usability by simplifying the use of this technology by a) using networking technology that can automatically configure itse
use an innovative solution to the usability of the sensor devices that is low cost and robust. Recent technological breakthrough in "smart du
ompletion of Phase II, we will have a) developed a text-to-speech (TTS) system that is usable on all major augmentative communication pla

hronic pain, and relief from opioid-induced bowel dysfunction. Successful development of a neutral opioid antagonist will lead to safer, mo

mechanical properties. Successful completion of this Phase I study will generate novel, delayed-swelling, hydrogel based, tissue expanders
ne and amended nasal swabs, lavage or sputum; and define process fow and instrument requirements for integrated fuidic cartridge deve
nostic system for the rapid, trace detection and characterization of RNA viruses, upper respiratory pathogens and infections. Infuenza v
umber of commercially available culture vessels. Small chambers that hold 1-3ml of solution are more and more frequently being used to s
am will be to build a fully integrated plate reader solution which can read 24, 96, or 384 well plates and simultaneously measure fuoresce
rapidly detect biomarkers for traumatic brain injury. The sensor will simultaneously detect a panel of ten to twenty protein biomarkers tha
scintillation properties, optical properties and imaging performance at RMD. Films will then be integrated into a specially developed high-
or gamma absorption, reducing gamma background and improving signal to noise ratio. The macromolecular (e.g. protein) structure strong
his new family of dyes, improvements to the optical system are proposed which includes use of sensitive Geiger mode avalanche detectors
nexpensive, safe, and easy to use instrument to test for the presence of lead in children's products, before they reach store shelves.

n protein molecules. The information on hydrogen location is important for monitoring protein dynamics and helps to understand nature o
r data free too. We, as do many others, believe that many great scientific discoveries lay implicit and just below the surface of the research

cell proliferation and (2) whether transdermal delivery of cannabidiol can prevent alcohol-induced behavioral pathology in a rat model of b

cion (LOS) for cancer based on the ultrasound appearance of breast masses. Also it is difficult to teach the method with high variability betw
on. In spite of recent advances in cancer therapy, the median life expectancy for patients with disseminated metastatic disease remains at
ng promising results using molecules radiolabeled with lead-212 in treatment for metastatic melanoma and disseminated colon and pancre
ext great opportunities for infuencing public health demand understanding the function of the cellular machinery created by our DNA's in
d on Bead Sorted Libraries of In Vitro Expressed Proteins (BS-LIVE-PRO). We propose to extensively optimize and evaluate this new technolo
development to ensure compatibility with large-scale commercial laboratory practices. Public Narrative There are an estimated one million
r. Paul Schroy, Director of Clinical Research for the Section of Gastroenterology at the Boston Medical Center. A critical goal will be to reliab
nsively evaluate these novel NF1 diagnostic assays. The ELISA-PTT will be improved to allow scanning of the entire NF1 coding region using
on of sensitivity and robustness. Last, we will integrate procedures for the extraction and quantification of miRNA to enable a streamlined m
rols for the clinical evaluation of the assay. In Phase II, we will evaluate the diagnostic value of the assay against a large number of clinical s

oviding the basis for breakthroughs in receptor structural biology. Specific Aim 2. Develop novel micelle-soluble cholesterol derivatives c
ng the chance of a patient acquiring an infection in a hospital - a public place. RHHP has the potential to reduce the cost of hospital acquire

clinical models of ALF combining co- morbid conditions, pharmacokinetics and safety studies) with the ultimate objective of using a small m
nimal model. Lung transplantation has become the mainstay of therapy for most end stage lung diseases including pulmonary emphysema,
t not statistically significant, activity over ANG 797. This Phase I application is focused on further optimization of the 2,4-diaminoquinazolin
rma. Dermal Fibrosis or Scleroderma, is a disease caused by a surplus of extracellular matrix protein localized in the skin, or it may become
Met and Tie2 kinase cascade pathways, down-regulate angiogenesis and neo-vascularization, ameliorate the course of the disease and prom
nd clinically relevant model of SCI, Refanalin improves neurobehavioral score, attenuates neuronal cell death and augments neuronal rege

ws: (1) Select additional multiple amino-acid auxotrophs of S. typhimurium to expand tumor-killing selectivity to additional tumor types, in

evelop this system and demonstrate its potential, we will synthesize three peptides, each of commercial interest, including human insulin f
d in the development of early-stage treatments and identify individuals for intervention before the devastation of late-stage vision loss.
contact mouse models. Use of both models allows a delineation of treatment effects toward epidermal hyperplasia and infammation. In a

odels. Finally, FDA-required studies will be completed to enable the submission of an Investigational New Drug application for the SK inhib
immune tolerance to xenogeneic islet grafts in a rat-to-mouse model for the treatment of diabetes. FasL will be displayed on rat donor isle
ins. There are three distinct advantages to this technology. First, chimeric ligands exist as tetramers and higher structures, and as such effec
ect against cancer but also against infectious diseases, leading to the development of an entire line of ApoVax104-based vaccines with sign

g of challenging protein crystals in a crystallization trial using digitally enhanced crystal detection. A side-by-side comparison with competin
eived the web-based course and those who receive standard didactic course material.
ve instruments to ascertain information about desirability, perceived effectiveness and utility. This proposed display system has the ability
By generalizing the PkPd models for use with inhaled agents and opioids, the display will be usable in a significantly larger portion of admi

uito monitoring technology for mosquito vector control applications. Mosquitoes are very important vectors of several deadly viruses, as d
erally considerably less expensive than current testing methods. With the successful completion of this grant, we will incorporate the sheep
ance of the stents 3. Conduct intra-tracheal pharmacokinetic studies to estimate drug uptake and tissue distribution in the local tracheo-br

id in an evaporation and contamination resistant manner; (2) the user-friendly dispensing mechanism can deliver 1-1500f aliquots touch-f
ed cross-domain knowledge resource providing fast and efficient access to the latest information about all aspects of drug mechanisms, me
al models and to determine whether the existing cell lines expressing mAb will be adequate to provide sufficient quantities for clinical testin
ant enzymes could be therapeutic in the treatment of the brain in human lysosomal storage disorders. 1 Zhang, Yun Project Narrative Lysos

nal vessel obliteration and diminish the neovascular effects of diabetic retinopathy.

esome for many individuals with type I diabetes because it can go undetected and it is one component in the progression of hypoglycemic u

). Aim 4: Characterize stem cell histocompatibility, infammation and tumor/ectopic tissue formation in rat and human MAPC to support sa
cutaneous injection. Such a formulation will not only significantly improve the well being of animals by reducing the dosing frequency and

mples inoculated with M. ulcerans and others inoculated with its closes relative, M. marinum. After sensitivity and specificity have been de
 effect, good ambient noise exclusion, a more stable coupling to the ear for reduced inter-subject variability, excellent comfort, and an exce
tic Synthesis (CES) approach to identify the structural modifications required to eliminate, or at least significantly reduce, the nephrotoxicit

he market for immunosuppressive drugs is expected to reach $2.5 Billion annually by 2008. Thus there is a market opportunity, even for a d
he benefit of this treatment is limited by the very short elimination half life of the drug necessitating frequent injections, which in addition
wo specific aims: 1) to generate higher-molecular-weight derivatives of TGF-a peptantagonists with potent antagonist activity. The methodo
scientific innovation that will allow for widespread clinical benefits by facilitating early and accurate diagnosis of AD, using a technique (SP
ncept clinical trial to image BCM in normal control and Type 1 and Type 2 diabetics. This imaging-based biomarker may represent a significa
graft and (ii) cellular removal and complete degradation of CSPG nerve growth inhibitors post-processing. Regeneration success in the goat
oamides, that will be needed for future clinical studies. Should we find AK295 unsuitable for further development, Axona has a library of o
standing of the BCG-host interaction in the development of protection against bladder cancer.
2) will be developed. Assay components (antibodies and antigens) will be produced in abundant supply and under quality assured conditio
hough considerable attention has been given to the development of psychometric instruments that facilitate the assessment of pain-relate
eal since it is tedious, subjective, labor intensive, and expensive, requiring specially-trained practitioners to evaluate stored image sequence
accurate results and be more appealing to patients and clinicians.

n and food service. Conventional techniques to test the effectiveness of sterilization processes, however, involve culture-based monitoring

nd software of the smart disk prototype should implement at least BLASTN- and BLASTP-like computations, run at least 30x faster than 200
eir student body (NIAAA, 2002a,b). At the same time they need alternatives that are less expensive, require less staff effort and training, ye
d a public health benefit potential if this web application is effective in helping individuals recover from their addictive behaviors. An autom
rovide a screening tool for early detection of elevated stress and the prevention of the onset of mental health disorders by mental health p

nts like PCT-A, beyond written text manuals or infrequent workshops. The intent of this project is to develop a uniquely comprehensive and

on assays in defined chemical gradients.

eeded in the pharmaceutical industry to improve the success rate in clinical trials, and in biomedical research in general to increase our un

ed with respect to the VSC phase. The technology is currently being developed as a leg press machine to improve mobility in older adults bu
e new technique with data either from the literature or from a crossover study employing a conventional technique. For example, the conc

rwise difficult to synthesize pharmaceutical intermediates. This research involves the development of new enzymatic catalysts for the manu
d with the BFI to that measured using conventional microelectrodes to both serve as a confirmation of the accuracy of the BFI and to furth
y of Minnesota's Center for Magnetic Resonance Research. Future Phase II plans will include multi-site human studies of image-guided bio
Phase I, Specific Aim 4a will evolve the use of empirically-based software development tools and practices identified in Specific Aim 2b, an
ucleotides with a 3' dideoxy terminated nucleotide that is not matched to its template DNA target are not efficiency activated by pyrophos
or cancer research and genetic research. Indeed, DNA samples used in these studies are often available in limited quantities. Amplifying th
cant benefits to public health. The research is particularly relevant to improved capabilities for the monitoring of cardiovascular disease sta
roposed here, the Database will be expanded to include these important fastidious species. As a third goal, our collaborator at Texas A&M
esponse teams (EMTs and ER staff) as well as military battlefield medics. Longer-term markets include continuous monitoring for pneumot
arterial blood gases and liver function response, and 2) improve protection as determined by animal survival seen at 3-7 days after hemor
mulate P-selectin, will enhance clot formation and clot strength effects of this agent, and; d) evaluate restoration of vital functions and survi
ure estimates incorporating temporal variability on the scale of minutes to decades. In addition, exposure will be calculated and displayed u
causes underlying the disparities in cancer incidence, mortality and morbidity observed across space and among sub-populations, as well
oject will be the first to address all of these factors within a single, comprehensive framework.

ia. We will then produce polyclonal antibodies in rabbits using the purified peptide fusion proteins. We will purify the antigen-specific antib
tivity that we can achieve, this approach could lead to the development of a single tier assay to detect antibodies against any of the three
he ticks that feed on them, breaking the mouse-tick cycle. The goal of this Phase I SBIR proposal is to test a bait vaccine against B. burgdorf

ated soluble TL1A. Undoubtedly, the successful completion of phase-I feasibility study will allow us to rapidly commercialize ELISA, and also

h is insufficient for full-depth anterior segment imaging. In this SBIR Phase I proposal, Bioptigen proposes to adapt their 1300nm OCT and h
onths of age. Both diagnostic assays are urgently needed in resource-limited settings. The lack of affordable and practical HIV diagnostics,
quantities from natural hosts or (b) catalyze the degradation or bioremediation of environmental toxins.
rter technology for extended versatility and multiplexing. Azoreductase will also be explored for further in vitro applications to facilitate mu

cted to evaluate voice quality and perceived speaker identity. Phase II will focus on developing complete acoustic inventories for several ca
om environmental microbiology can bring about significant advances in the understanding of these illnesses. There is a growing recognition

ealth burdens experienced by African Americans in the U.S. - obesity, breast cancer, cardiovascular disease, diabetes, and hypertension/str

ues, mass spectrometry is generally faster, providing both separation of complex mixtures and a fundamental measurement simultaneousl
e us towards a feasible sensor design ready for human studies after completion of this project. We believe strongly that both the substantia
development of future therapeutics for apoptosis related diseases.
integrate recording capabilities into existing automated patch clamp software from Nanion, (2) evaluate the success rate of the procedure
by macular degeneration, diabetic retinopathy, glaucoma, cataracts, and other eye problems, increasing mobility and independence for th
ntation of the prosthetic shoulder socket, thereby improving effectiveness of the prosthesis and lowering the risk of postoperative complic

itis (RA) is a chronic infammatory disease that causes progressive joint destruction, deformities and disability. Vascular endothelial growth
s to determine the efficacy of drugs in drug studies.

ents, Foley catheters, and ureteral catheters. 2. Evaluating important AMNC characteristics such as hydrophobicity/hydrophilicity, coefficie
n vitro, ex vivo and in vivo assays developed in UCLA, Colgate-Palmolive and C3 Jian Inc. The successful execution of this research plan will f

jor technological advantage, for the first time; truly label-free binding measurements available for all proteins and most drugs. Furthermor

n can be directly observed and quantified. (3) Select an elite set of compounds to be evaluated as therapeutic candidates in Phase II. Confir
eded and translational studies (chemical scale-up, animal safety and efficacy, ADME/T) required to support the submission of an investigati

e commercial development of this potential therapy (autologous, at least initially), as well as pivotal to a successful FDA Biological IND filin
(for clearance) and B-cell killing (for efficacy) will be evaluated. We believe these first two specific aims will lead to a doxorubicin nanoparti

est Practice program among colleges and universities as well as in health care centers serving the needs of college students.
, HUCBC transplantation, and AD pathogenesis. This knowledge is used to rationalize U-CORD-CELL" as a potentially safe and effective imm
udies designed to assess product safety, and optimize production for use of these progenitor cells in the commercial development of a Typ

cancer as well as an alternative method for treating renal and liver cancers. Consequently, this novel therapeutic design will provide a majo
seful as a nerve-sparing treatment as well as an alternative method for protecting other tissues, such as the urethra. Consequently, this no

es in a cell-based assay. In collaboration with our biology consultants at the Cleveland Clinical Foundation, we will subsequently validate thi
etween genes, and the establishment of animal models. Moreover, we envisage a major impact on the molecular dissection of human dise
evelopment of increasingly relevant paradigms for drug discovery. As a result, we foresee that these toolsets will significantly improve the e
e survival and quality of life of this population. The availability of a safe and effective, "off-the-shelf" treatment will also have a significant p

real-time PCR viral load test with less than 15 minutes labor and without using an expensive automated sample preparation system. The p
ells. CDI's combined expertise in hESC biology, cardiac electrophysiology, cardiac safety pharmacology, and clinical cardiology makes it high
on a national level, at a rate of about 4 errors per day in a pharmacy filling 250 prescriptions daily. Public health is seriously affected due to
tise in novel Raman spectrometer design and manufacturing, to create a unique diagnostic point-of-care system. There is an urgent ne

generated and specifically screened as antibacterials and antivirals. Given the unique activities of megalomicin, it is anticipated that a com
wn to be correlated with cardiac arrhythmias in humans, and (iii) determinations of the effect of new analogs on induction of cancer cell a
rated into the base perfusates. The second step will entail a comparison of pancreas perfusates with the addition of the cytoprotective coc

he mission of NIEHS, EPA and ICCVAM. Recent scientific investigations have shown that many (perhaps over 10,000) chemicals used in com
vity. We will also determine the effect of these novel compounds on retinal NV in oxygen-induced retinopathy (OIR) rat model, which is a co
ogen contains 5 kringle domains, each consisting of 80 amino acids. Angiostatin consists of the first 4 kringles (K1-4) of plasminogen. K5 has
R and commercialization. In this Phase II project, we will further investigate its long-term efficacy, pharmacokinetics, toxicities and molecula
ombination of the most seroreactive antigens will be used to develop a prototype lateral fow diagnostic test to detect the greatest numbe
enzyme products to small volumes. Objectives of this second thrust will be to obtain optimal fabrication and operation conditions to make

This effort will produce a computer-based, game-like product that will provide trainees in house staff programs, including medical and surgi

develop and validate a chip designed to assay the presence of relevant analytes in human samples. The platform developed in Phase I wou
ase-of-use. At present, there are no systems available that offer the breadth of capabilities, the simplicity of use and limited sample size req

nical interface software. The base station will detect area modules, process data, and report clinical details. The clinical system will aid in ea
ectly in serum and brain of pharmacoresistant patients or in our in vitro model comprising of cells from comparable multiple drug resistant
of the website on knowledge, self-efficacy, depression, and caregiver burden. Qualitative feedback and website usage data will also be obt
l use the clinical content refined under the first aim to produce the next 5 hours of education on assessing suicidality in Emergency Departm
studies outlined in the proposal will help provide the data necessary for advancing a compound to clinical testing.
bral microvascular amyloid-induced neuroinfammation, behavioral deficits and resulting pathology. Ultimately, if successful, this therapeuti
acid derived from our diets, that is converted to polyamines through the action of the arginase/ornithine decarboxylase pathway. We have
of a debilitating disease that presently affects over 500,000 predominantly elderly Americans. Advances made through the proposed proje
roved therapeutic for treatment of sepsis syndrome.
agent for the demyelinating disease, MS, either as a supplement to the current immune-modifying therapies, or as an anti-infammatory its
essed through the safety pharmacology required by the FDA for submission of an IND application. The completion of the project will also d
in vivo to demonstrate efficacy in reduction and fixation of small bone fractures. This research project will include 1) finalizing the product
product performs adequately when delivered by the new device. During Phase II of the project, the sprayable adhesive will be tested in vi
an effective vaccine, but with current vaccine manufacturing capabilities it could take years to produce enough vaccine to protect the US p
les. The final system will be used by a group of non-native ESL learners to demonstrate the effectiveness of including explicit perceptual tra

tive drying routes. Throughout this Phase II we will work closely with our industrial partners. This program develops a low cost, simple, proc

blood glucose and glucose tolerance in the ob/ob mouse model of type 2 diabetes. It is anticipated that these studies will lead to the deve

ent in CI technology. Individual CI patients will be evaluated more quickly and more accurately.
ely 100 ms without increasing the vacuum chamber's pressure beyond about 10-6 Torr. A TOF can be operated in this pressure range and s
am Overview, Understanding Chronic Pain, Profile of Chronic Pain Self-Assessment, Results, and Recommendations, and four Self-Managem
nes a hierarchical, octree decomposition of the domain and a singularity-free representation of the potential solution to minimize grid poin
rt, visual distortions, risk for bacterial proliferation and keratitis. The use of a biological tissue adhesive, with sufficient sealing properties to

odeling to determine optimal dimensions of the device, and precision manufacturing of smaller, more compact devices for improved treatm

will be a marketable Computer Adapted Testing (CAT) version of the Late Life-FDI, an instrument that has great promise to improve function
as well as their integration with the stabilizers. The preparation and evaluation of full LifterMate prototypes will complete Phase II and prec

timulator to develop client-specific stimulation patterns to elicit the proposed recumbent stepping movement across subjects and visits wit

s high risks for elevated methemoglobin levels, a realtime, noninvasive methemoglobin sensor will become an invaluable tool especially for

growing dramatically, resulting in a worldwide shortage of GMP manufacturing capacity for these proteins. Therefore, methods to improve

ruction of viruses and tumors, while helping to prevent transplant rejection and autoimmune diseases.

d delivered in a therapeutically effective fashion.

he reasons for this are clear: The apparatus necessary for the routine and safe preparation and manipulation of the highly pressurized and f
e training resource to assist adolescents and young adults with AS/HFA as they transition from high school to post-secondary settings. By p
d content with an expert Advisory Panel; 4) Develop an outline for an accompanying DVD, to be produced in Phase II; and 5) Conduct a fea
ns, a Clinician Online Course, a Cosmetologist CD-ROM Tutorial, a Recovery Web Site, an Education Video and Facilitator's Guide, and a brie
ees. Given the high rates of undertreatment of children with mental health needs, FETP will contribute to public health by ultimately impro

lot evaluation. Given the shortage of research-based psychoeducational curricula for adolescents with substance use problems and their fa
 -a broadband capable, cellular telephone keyed into a highly interactive informational web site. This web site will provide engaging, teen-t
tation for SBIR and STTR Grant Applications states that "the mission of the National Institute of Mental Health (NIMH) is to diminish the bu
m development experts, none of the comprehensive substance abuse education programs currently available include gender-specific inform

ers, the following market segments: institutional caregivers, nurses, educational institutions and the lay public. This study projects a first ye
hinese market. Current information on where population growth is occurring in China is critical in predicting environmental impacts of incr
g, published, periodontal surgeons. The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2
eir suggestions, focus group data, and suggestions of our scientific and training consultants to develop a prototype Web site. This will emplo
ricula, develop final versions of the web-based training program with an accompanying DVD-ROM to be used by instructors in oral health c

ommunities healthy. Creation of NEED-PLUS will make useful, age-specific data more broadly available and will provide improved care and b

antigens chosen. Specific Aim 2: Show how well Differential Capture Proteomics detects the differences between two human plasma sampl
tides that bind specifically to model targets (monoclonal anti-peptide antibodies) with the lowest background obtainable. Specific aims 3 a

the discovery of novel small molecule drugs that regulate this important class of proteins and could provide for the generation of new dru

DNA and transposase-encoding sequence will be introduced into HSC using Cyto Pulse electroporation technology. Results from these expe

d on a failed paradigm that includes monitoring and recording data that has no correlation with the potential for noise-induced hearing loss
nally, the most promising compounds will progress into rodent model trials of lymphatic filariasis. The expected outcome of this work is the
highly accurate microscopic imaging device. This device will generate high-resolution digital images for use in telemedicine, reduced turnaro
thus will positively impact the quality of life of a significant segment of humanity. ThermoBLAST will make a major positive contribution to
on dose actually delivered.
K) platforms for H/13C at 7 T and 11.7 T will be developed, fabricated, and then tested at other institutes, yet to be finalized, but likely the N
abundance formamide. Achieving the desired rf field strengths will require 4 kW rf pulses for 15N (90 MHz), 1500 W rf pulses for 13C (225

ndividual detector modules (tiles) arranged in a (one- or two- dimensional) array so as to form the entire detector. Each detector module (ti

ware into existing transcranial Doppler systems in order to provide a new, widely applicable, practical tool for evaluation of cerebral autore

logy provides a new solution for this call. If successful, Echemics aims to commercialize this novel technology for growing the company and
ht of a 12-month- old reference boy is about 10.15kg (Heymsfield et al., 2005). The overall aim of Phase I of the project is to validate the pr
while maintaining sensitivity toward bacterial proteases. The next goal is to demonstrate the efficacy of the new target peptide in detectin

rtant health-related problems in the US and worldwide. Improved sensors for detecting mycotoxins and thereby revealing the presence of
nsist of HG peptide incorporated into biodegradable hyaluronan microbeads that will be injected into the gingival pocket to provide sustain
construct will be modified to target the protein to several different organelles in the plant cell, thereby optimizing SLPI production and accu
second aim, we will assess the extent to which serum and tissue proteins in general will serve as substrates for this process. Using serum a
oject will address the potentially devastating effects that low literacy can cause in children's lives and in society at large. Since vocabulary d
helped develop the glass nanopores. This project proposes a new system to improve the quality of ion channel current measurement techn
e, with direct impact on our society. Continued early introduction to science might also stimulate career opportunities for young students t
ed limits, show an adequate usable field lifetime for the SERS sensing elements, design a fieldable reader, perform a detailed interferences
of the arrays as blanks and with selected MRAs. The market and products are similar to existing protein microarray products, with the new

n of infarct, but rather at all relevant time points of infarct tissue development, both reperfused and non-reperfused. Thus we plan to dem
de reduced time for caregivers to review behaviors of interest.
t clones according to indicators of their mechanisms of action and effectiveness against diverse MRSA isolates, (3) determine chemical stru

oviding tools that will help practitioners put scientifically generated knowledge about intervention effectiveness into practice. The current e
ong policy focus on utilizing alcohol and other drug (AOD) indicator data in developing comprehensive prevention plans. Federal funding to
thesis. These varieties of voice gesture have been reported by users of AAC devices to be needed. Subjects for testing and evaluations will
, regulatory and reimbursement strategies so that we will be well positioned to bring this device to market following completion of the R&D

mploying nucleic acid and immunological assays and electrochemical and other detection methods. Specific assays will be developed by th
tive and highly accurate way to monitor arsenic in drinking water at the site of the water source. The long- term vision for this technology i

rug Abuse's objective that all members of society understand the roles of science, biology, and technology as they relate to neuroscience, b
and immunosuppression. The proposal consists of two specific aims: 1. Construction of mice transgenic for the human RHD and RHce gene

e 10 pounds/$3,500. APD is now 14.7 ounces/$600, and portable. In Phase II we plan to further reduce its size and cost, improve the fow s
rabbit embryonic stem (rbES) cell lines. The success of this project will establish the first germline competent ES cell lines in a non-murine s
rapy. This project proposes that inhibition of the intrinsic coagulation pathway, to be accomplished by inhibition of a key enzyme of this pa

and progression of malignant brain tumors. These results will provide sufficient data to proceed with a phase II study, the aim of which will
ination of basic parameters of lacritin absorption, distribution, and excretion, (3) Economy of manufacture, stability and optimal shelf life in
ogy for splice variant detection. The continued development and expansion of this technology holds great promise for new insights into can
to perform and technically challenging, due to a paucity of trained personnel. Treatment efforts currently underway, such as the World He

n HLA transgenic mice and Factor VIII deficient mice. Epitope-driven deimmunization of factor VIII 12,000 Americans have the blood clottin
d enantiomeric ions, to analyze and compare chiral separation characteristics of CIMS and chromatographic systems, and to explore the po
hat reliably measures ethanol concentrations in real-time collects and preserves EBC for later analysis. (Milestone: Availability of device by 1
the gas phase concentration of two suitable EDIMs identified in Specific Aim 2. Nonadherence to prescribed medication regimens is a ma
0-cholesterol molecules, 3) Characterize ATE considering solubility and MRI relaxivity parameters. AIM 2: Examine the cellular uptake o

ogy could make the difference between a drug making it to market, or being abandoned due to inadequate supply of the drug for testing o

ugation chemistry. The third aim will also include the optimization of the UCBf assay for use in a high throughput format to facilitate future
nds in diabetic C57BL/KsJ-m+/+Leptdb (db+/db+) mice has any systemic effects as evaluated by blood analyses and necropsy. Present ther
he proposed work will develop another platform technology, this one allowing the detection of nucleic acid targets through a novel combin

interpreters when used for specific types of interactions and that nurses and patients will adopt the technology as a routine part of patient
, resulting in prostheses that perform better and last longer.
ant biomolecules such as peptides and carbohydrates will be made, purified and immobilized for further study.
its required reagent volumes.
ervention planning, and evaluation will be available, as well as technical, research, and professional peer support. An advanced search eng
and if left untreated causes blindness. We will create an electronically controlled valve and pressure recorder to be placed in the eye that
based on these host targets will then be screened and developed. The major advantages of RHGP technology over other gene inactivation o
ping firms, 2) to test a complete list of quality and safety factors including noise figure, stability, low-input impedance and linearity tests usi
hese data serve as the basis for our hypothesis, which states that the relative abundance (or ratio) of these two competing receptor mecha
nical tests predictive of antidepressant effects in humans. In addition, because DAT transporter blockade has some liability for abuse, for th
s software to get a 3-D runway defection and defects profile with ground marks as a function of space and time. In addition to the airport

e eddy current brake.

100 technologies, sorted into broad categories, of interest to NASA. "
true green process for water conservation and reuse along with significant energy savings. In addition to the boiler fue, during Phase I, ad
Toxicity (WET) testing.

“true” green process for water conservation and reuse along with significant energy savings. In addition to the boiler fue, during Phase I,
and supported processes will be presented to DOD Logistics Program Offices for evaluation and potential incorporation into formal impleme
ify both hemocompatibility and calcification resistance provided by the polyurethane valve design. Existing replacement valves suffer from

nt standard practices, and (4) supervising others who interact with those at risk for pressure ulcer formation. These will be developed using
thout the requirement for special security arrangements. Critical variables on the restricted- release data from the Social Security Administ
al clinical study to evaluate performance. This proposal is in response to PA-06-013 which is in response to an Executive Order 13329 from
stress to induce cell death in a retinal pigment epithelial cell line, ARPE-19, and to identify cytoprotective compounds against such stress.
or a larger Phase II demonstration effort. Phase I will also provide sufficient data for Ocuscreen to be nominated as an alternative test meth

rstood and retrievable by researchers; (7) investigate options for integrating Medicare/Medicaid information into Census? newly-establishe
inistrative sources and to meet the needs of a broad range of researchers and policy analysts; (6) prepare plans for comprehensive data do
alent carbohydrate display, with globular shapes that are suitable for probing carbohydrate-protein interaction. In Phase II, we will develop

practicing prosthetists in the Shriners Hospital network through the design phase and into clinical evaluations. By partnering with Shriners,

of Cincinnati, is developing a process to positively impact these obstacles through a novel use of ultrasonic technology. The system we desc

edicine, military applications, education/training evaluations, and occupational medicine. The plan for the Phase I is to build upon this foun
e a comprehensive program that be implemented to facilitate early identification and efficacious treatment for patients with loud snoring a

somal storage disorders including Pompe, Fabry, and Hurler diseases from a single dried blood spot obtained from the heelstick of a newbo

ll phones as they did with their home computer. It is the goal of this project to start the development of medical devices that will allow ful

Parkinson's disease.

s and specificity of anti-GP88 Mabs by Biacore analysis. 2. Identify Mab's with maximal efficacy and potency in relevant in vitro functional c

s to develop a novel blood test for NSCLC that can be rapidly translated into clinical practice. A blood test for early detection of lung cancer

ory studies into clinical gene therapy studies, with patient accrual at the Massachusetts General Hospital (MGH), which has an active brain
ch tool for investigating exposures that initiate and exacerbate asthma and COPD.
cts. The overall mission of Aerophase Inc. is to improve healthcare through aerosol medicine. The primary purpose of the proposed projec
ether product, and 3) demonstrate that we can design and fabricate an advanced prototype that combines the extraction, reaction, and sep
rly development risk by triaging public gene expression data to progress directly to product identification and late stage clinical studies for
ate DiscTreadmill efficacy and limitation, in particular the piezo-based sleep restriction method, by simultaneously recording EEG/EMG and
original touchscreen apparatus using a mutant mouse model (rl-/+) and the NMDA antagonist MK801 known for its effects on cognition an
ctional tissue repair in animal models of disease. We have chosen engraftment of myoblasts as our initial proof of principle focus because t
ts (an aminoglycoside and a tetracycline) commonly used both locally and systemically to prevent or treat implant associated infections. Br
es, we will identify tricalcium phosphate (TCP) binding peptides. Next, we will synthesize combinations of Affinergy's existing BMP-2 and os
is envisioned to select and concentrate osteoinductive molecules as well as a functional population of osteoprogenitor cells. Finally, to be m
ehavioral disorders such as depression or post-traumatic stress disorder. The proposed device will be useful in the area of aging research, fo
 membranes in an animal model for healing by 2x intention. Membranes will be pre-treated by parameters established in vitro then secure
increase glycosylation and enhance growth factor binding, while addition of a COOH-terminal tag on the prototype transgene will enhance
can automatically configure itself without the need for technical experts, and b) incorporating Phase I user-interface and content feedback
ogical breakthrough in "smart dust" wireless sensors has provided an elegant and cost effective method to build distributed autonomous m
augmentative communication platforms, b) developed a distributable software and hardware package for automatic personal synthetic voic

d antagonist will lead to safer, more efficacious pain and addiction management that is needed by millions of people each year. Opioid analg

hydrogel based, tissue expanders which do not suffer the drawbacks of current tissue expansion technologies. These tissue expanders will n
integrated fuidic cartridge development, production and testing in Phase 2. Successful completion of the project Milestones will provide s
ns and infections. Infuenza viruses are highly contagious and cause approximately 114,000 hospitalizations and 20,000 deaths annually
more frequently being used to store and grow live cell cultures. Healthy tissue growth requires the exchange of fuid media and the availab
multaneously measure fuorescence intensity, polarization transfer, and fuorescence lifetime at each well. In the Phase II program, we plan
o twenty protein biomarkers that are used to diagnose and monitor brain injury. The sensor is based RMDs proprietary photon counting de
into a specially developed high-speed readout by RMD and evaluated at the BioCAT beam line at the Advanced Photon Source (APS), Argo
lar (e.g. protein) structure strongly relates to its function and properties. Neutron crystallography can precisely pinpoint location of hydroge
Geiger mode avalanche detectors (GPD) and use of correlation technique. Demonstrating three-dimensional optical imaging using fuoresce
they reach store shelves.

nd helps to understand nature of disease. The proposed detector could be employed at any neutron source facility and would help to adva
elow the surface of the research literature. All that is required is for the right researcher to see the right sentence or database entry to form

oral pathology in a rat model of binge drinking. Behavioral pathologies associated with AUDs include preoccupation with the drug (persever

method with high variability between radiologists. Almen Laboratories with its clinical collaborators has developed a sophisticated com
d metastatic disease remains at 12-15 months. There is a clear need for the development of new and efficacious therapy agents to attack m
d disseminated colon and pancreatic cancers. Another isotope, radium-223 is being used in clinical trials in treatment of skeletal metastase
achinery created by our DNA's instructions. In order to achieve this goal, it is imperative that technologies such as AlphaSniffer's SPR-CPI pla
e and evaluate this new technology during Phase II with the aim of commercializing diagnostic assays for autoimmune diseases.
ere are an estimated one million people in the U.S. infected with HIV-1, with 40,000 new cases reported each year. Optimal treatment of th
er. A critical goal will be to reliably detect less than a 1% level of chain truncating APC mutations relative to wild-type protein. Enhanced sen
e entire NF1 coding region using mRNA isolated from patient blood and a single-step PCR protocol. The MASSIVE-PRO assay will also be im
miRNA to enable a streamlined method for miRNA detection. In phase II, we will refine and apply this technology using emerging miRNA b
ainst a large number of clinical samples in a diagnostic laboratory setting. We will develop software for analyzing the assay results and to a

soluble cholesterol derivatives can be used to enhance the solubility and functionality of the micelle-solubilized KOR and other GPCRs. A n
educe the cost of hospital acquired infections by a billion dollars and a hundred thousand deaths per year in the United States.

mate objective of using a small molecule SF/HGF-mimetic for therapeutic use in ALF. Acute liver failure remains a significant cause of morb
 cluding pulmonary emphysema, cystic fibrosis, and idiopathic pulmonary fibrosis. A small- molecule drug that increases the preservation ti
tion of the 2,4-diaminoquinazoline scaffold with the goal of identifying more potent c-Met/Tie-2 antagonists that can be advanced towards
ed in the skin, or it may become systemic with excess collagen collecting in the kidneys, lungs, gastrointestinal tract, and heart. Scleroderm
e course of the disease and promote functional recovery in CIA. At Angion, we are using the Met crystal structure, molecular modeling, and
ath and augments neuronal regeneration. A comprehensive and good laboratory practice adherent set of regulatory studies indicates that a

vity to additional tumor types, including patient tumor models; (2) Determine possible significance of host immunological status by compa

terest, including human insulin for treatment of diabetes, psalmatoxin peptide for pain research, and MUC7 peptide for treatment of funga
tion of late-stage vision loss.
perplasia and infammation. In addition, the effect on barrier function will be assessed by measurement of transepidermal water loss (TEW

Drug application for the SK inhibitor ABC294640. The following Specific Aims will be addressed: 1.) To evaluate the protective effects of ABC
will be displayed on rat donor islets for transplantation into both chemically-induced diabetic mice and spontaneously diabetic non-obese d
her structures, and as such effectively crosslink their receptors on immune cells for potent signal transduction. Second, chimeric proteins c
Vax104-based vaccines with significant potential in the millions of dollars. Immune system-based treatment of cancer represents an alterna

-side comparison with competing commercial protein crystal imaging instruments will be carried out. It is anticipated that the Crystal Finde

ed display system has the ability to significantly increase patient safety by reducing the number of errors associated with misinterpretation
gnificantly larger portion of administered anesthetics worldwide. By accounting for additional model covariates, such as the opioid tolerant

rs of several deadly viruses, as demonstrated by the rapid spread of West Nile Virus through North America via a combination of bird move
nt, we will incorporate the sheepshead minnow microarray and its database into our existing product line and sell it to the EPA, USGS, rese
stribution in the local tracheo-bronchial and lung area. 4. Develop and coat 3 prototype biodegradable polymer-drug(s) formulations on a r

deliver 1-1500f aliquots touch-free with state-of-the-art precision; and (3) a user- friendly archived-liquid sample tracking database applica
aspects of drug mechanisms, metabolism, and toxicity. Second, this knowledge can be used as a training set for building toxicological comp
fficient quantities for clinical testing. We will also investigate whether a mAb can be formulated and delivered optimally as a liquid in a mous
ang, Yun Project Narrative Lysosomal storage disorders are serious inborn errors of metabolism, and about 75% of the ~40 lysosomal stora

he progression of hypoglycemic unawareness. The proposed nocturnal alarm represents an innovative approach to reduce significantly the

and human MAPC to support safety of IV MAPC in rat neonatal HI model. The overarching goal of this STTR Phase II study is to provide the
ucing the dosing frequency and stress to the animals, but also save considerable time for veterinarians and their staff treating the animals.

vity and specificity have been demonstrated in Phase I, actual samples from highly endemic areas will be analyzed. Further development o
 y, excellent comfort, and an excellent frequency response. Although this design is adequate to meet the requirements for automated testin
cantly reduce, the nephrotoxicity associated with a cyclic peptide antibiotic that currently cannot be used systemically. The CES approach c

market opportunity, even for a drug formulation that helps only a minority of patients. Because the likelihood of success is high (we know
ent injections, which in addition to additional discomfort and inconvenience may actually lead to a progression of the underlying disease. T
antagonist activity. The methodologies will include chemical synthesis, biochemical, cell biological and plasma clearance assays and 2) to de
osis of AD, using a technique (SPECT imaging) appropriate for the primary care / community medical setting. In addition, it will allow for sci
marker may represent a significant advance in diabetes management by allowing better diagnosis, disease monitoring, and therapeutic sel
egeneration success in the goat will be determined by (i) evidence of regeneration into a muscle target to the level of muscle contraction u
opment, Axona has a library of over 120 Calpain inhibitor compounds that we would then further characterize. AK295 will be a "first in clas

d under quality assured conditions. Feasibility data will be collected from clinical studies of severe, moderate, and mild TBI that will allow c
te the assessment of pain-related disability, collection of accurate data via questionnaires remains an issue in practice (e.g., self- report me
evaluate stored image sequences of line. To overcome these limitations, we propose to develop the General Movements for the Identificati

nvolve culture-based monitoring that can take up to four days to complete. To provide more rapid sterility assurance, BCR Diagnostics has

, run at least 30x faster than 2003-era commodity general-purpose processors, and successfully hide the complexity of the engine's hardwa
e less staff effort and training, yet are empirically supported. The CDCU, if effective, could help meet those needs.
ir addictive behaviors. An automated, evidence-based program that helps individuals with alcohol, drug, and non-chemical addictions will
alth disorders by mental health professionals. The President's New Freedom Commission has recommended that the screening and early d

p a uniquely comprehensive and interactive online training in PCT-A, in order to improve clinical outcomes for adolescents suffering from p

rch in general to increase our understanding of disease mechanisms. In this proposal we plan to develop and commercialize a Microfuidic

mprove mobility in older adults but is transferable to training of other muscle groups. Aims of Phase II: System mechanics, electronics and so
echnique. For example, the concentration of the same drug will be compared in blood sampled manually from a restrained pig vs blood sam

enzymatic catalysts for the manufacturing of drugs and drug intermediates. These new catalysts offer many advantages compared to the ex
accuracy of the BFI and to further demonstrate its advantages over the direct contact measurement approach. If the handheld BFI is able
man studies of image-guided biopsies, marker placement, and therapies such as cryoablation, radiofrequency (RF) ablation, and percutaneo
s identified in Specific Aim 2b, and will establish a regular observation/documentation cycle to measure their impact. Phase I, Specific Aim 4
efficiency activated by pyrophosphorolysis while oligonucleotides whose 3' ends are perfectly matched to their template can be activated.
limited quantities. Amplifying the entire genome enables researchers to perform more tests on the samples than would otherwise be poss
ring of cardiovascular disease states, and biomarkers in general, and the NHLBI's national efforts to prevent, detect and control hypertensio
, our collaborator at Texas A&M University will focus on the most important genus, Mycobacterium, and use knockout strains with PM tech
tinuous monitoring for pneumothorax, for example in an intensive care unit after cardiac surgery. BIOMEC has had significant discussions w
val seen at 3-7 days after hemorrhagic shock. The study will also assess the response of the molecular pathways associated with hemorrha
ation of vital functions and survival. Phase I proposed studies could provide the "proof of concept" for the use HAF as an intracavitary hem
will be calculated and displayed using alternative temporal orientations, including participant's age, calendar year, and the number of years
among sub-populations, as well as lead to a better assessment of the benefits of current strategies for reducing these disparities.
 l purify the antigen-specific antibodies from the serum using a two-step affinity-based procedure. Finally, we will evaluate the performance
bodies against any of the three pathogenic genospecies of B. burgdorferi in both early and late Lyme disease. Lyme disease, the most
bait vaccine against B. burgdorferi via ad libidum feeding of the major host reservoir of this spirochete, the white-footed mouse.

dly commercialize ELISA, and also to demonstrate the feasibility of ELISA to detect soluble TL1A in human clinical sera. As TL1A will likely me

o adapt their 1300nm OCT and handheld probe technology for high speed, handheld, full-depth anterior segment imaging which will make
e and practical HIV diagnostics, including assays to monitor HIV RNA levels ("viral load") is a major barrier to HIV care worldwide. BioScale'

vitro applications to facilitate multiplex detection Technology to be developed under the proposed research should find broad applications

coustic inventories for several canonical speakers that will be selected to cover a range of speaker characteristics, and on producing portabl
es. There is a growing recognition of the importance of microfora in health and disease not limited to IBD but also in other areas such as co

e, diabetes, and hypertension/stroke. This project will use a medium that transcends social class and can be used effectively especially given

ntal measurement simultaneously. In addition to microbial identification for clinical response, diagnostics are also needed for a wide range
strongly that both the substantial amount of preliminary work and our team of experts will enable us to successfully accomplish the propo

e success rate of the procedure specified by our machine learning analysis, and (3) develop stand-alone software for use specifically with m
mobility and independence for those with acuity between approximately 20/200 and 20/600. At under $1,000, the total market for such a d
he risk of postoperative complications.

ity. Vascular endothelial growth factor (VEGF) appears to play a critical role in this infammatory process and therefore, is a reasonable targ

hobicity/hydrophilicity, coefficient of friction, adhesion and wear resistance. 3. Developing predictive knowledge of activity and effective lif
cution of this research plan will further improve the STAMP technology and lead to the development of a targeted antimicrobial therapy ag

eins and most drugs. Furthermore, our technology has the potential to provide benefit to all biomedical and pharmaceutical research which

tic candidates in Phase II. Confirmed actives from the primary screens will be evaluated for efficacy and potency via dose response assays a
t the submission of an investigational new drug application. The results from this research will also enable us to validate DJ-1 up- regulation

uccessful FDA Biological IND filing.

 lead to a doxorubicin nanoparticle design capable of circulating through the vascular system long enough to allow targeting ligands to dire

college students.
otentially safe and effective immunomodulatory therapy for AD.Project Narrative - Relevance to public health. In summary, we hypothesize
mmercial development of a Type 1 diabetes cell therapy. Approximately 1.6 million people are insulin-dependent. Type I (usually juvenile-o

peutic design will provide a major benefit to the clinical area as well as provide a platform for future development of minimally invasive the
e urethra. Consequently, this novel therapeutic design will provide a major benefit to the clinical area as well as provide a platform for futu

we will subsequently validate this library in transcriptional reporter cell line models, to identify effector peptides of NF-?B signaling pathway
lecular dissection of human disease mechanisms. For example, these reagents harbor considerable promise to identify new targets for the
ts will significantly improve the efficiency, economy, and ease of performing HT RNAi screens, and will provide basic researchers with prefe
ment will also have a significant positive impact on the ability of local and federal governments to respond to mass casualties as a result of

mple preparation system. The proposed studies will evaluate the feasibility of using polymer coated magnetic particles to isolate and conc
d clinical cardiology makes it highly feasible to achieve the Phase I goals. Preliminary study using lentiviral transfection system to validate po
ealth is seriously affected due to prescription errors, including as many as 7,000 deaths annually in the United States. This system is develo
ystem. There is an urgent need for easy-to-use, rapid, and cost-effective medical diagnostics for public health clinics, field and point-of-c

micin, it is anticipated that a combination of antibacterial and antiviral screening of the neoglycorandomized prototype libraries proposed m
ogs on induction of cancer cell apoptosis mediated through the Src/EGFR/ERK and TNF-alpha receptor/NFkB signalling pathways. Our goal
ddition of the cytoprotective cocktail for machine preservation of fresh pancreata with no warm ischemia. Then the interaction between co

r 10,000) chemicals used in common products such as plastics, pesticides, cosmetics, and food additives have estrogenic/anti-estrogenic ac
thy (OIR) rat model, which is a commonly used model of proliferative diabetic retinopathy. These studies may identify novel compounds wi
es (K1-4) of plasminogen. K5 has a more potent anti-angiogenic activity than angiostatin. Our previous studies have shown that intravitreal
okinetics, toxicities and molecular mechanisms of action, to obtain essential data for FDA approval and commercialization of this new comp
est to detect the greatest number of acute-phase patients, while avoiding antigens recognized by control subjects. The point-of-care diagno
nd operation conditions to make an actuator of the desired size operate in the same conditions as the sensor. The overall goal of the Phase

ams, including medical and surgical oncology fellows, with a realistic simulation experience of caring for African-American breast cancer pa

tform developed in Phase I would be used in Phase II for human clinical studies. 7. Project Narrative The proposed research aims to develo
f use and limited sample size requirements as the proposed T cell analysis system using MHC-peptide arrays in the fight against T1D.

The clinical system will aid in early screening by objectively quantifying several key PD symptoms including motor features, olfaction, sleep
mparable multiple drug resistant subjects. 3) To develop an automated drug dosing and sampling system to allow for automated control, da
bsite usage data will also be obtained. BENEFIT: Educating caregivers about dementia and providing tips and tools to assist with caregiving
 suicidality in Emergency Departments; 3) Evaluate modules 2 through 6. Using questions based on the content of modules 2 through 6, tho
testing.
tely, if successful, this therapeutic regimen would represent a novel and effective treatment for neuro-infammation associated with amylo
decarboxylase pathway. We have found a novel drug, COG112, can stimulate this arginase activity. Thus, mouse models of colitis treated wi
made through the proposed project could lead to new therapies that reduce the debilitating effects of the disease and lessen the burden on

es, or as an anti-infammatory itself, the remyelinating properties of COG compounds that we propose in this grant might fill the tremendo
mpletion of the project will also deepen our understanding of the disease and confirm that we have identified a novel therapeutic target for
include 1) finalizing the product specifications, 2) performing efficacy testing in an accepted animal model for small bone repair, 3) establis
able adhesive will be tested in vivo to demonstrate efficacy in closure of planar tissues and preventing post-surgical fuid accumulation. Thi
ough vaccine to protect the US population. We need vaccine additives that can extend the effective dose of a vaccine to cover more people
including explicit perceptual training in a program of ESL instruction. Summarizing, the final product will be a complete perception training

develops a low cost, simple, process to recover pharmaceutical solvents. This will encourage solvent reuse which is environmentally attracti

hese studies will lead to the development of a new class of novel antidiabetic and antiobesity agents based on the puerarin structure.

ated in this pressure range and several thousands TOF mass spectra can be obtained in this short interval of time. The "personal Exposure M
ndations, and four Self-Management Modules. In addition, a number of interactive tools will be available for use across the Self-Manageme
al solution to minimize grid point count and thus computational cost. A new, self-consistent outer boundary treatment is also used to redu
th sufficient sealing properties to resist sudden changes in intraocular pressure for a prolonged time, may be of great benefit for the synthe

pact devices for improved treatment and enhanced patient comfort. Every year, about thirty thousand cases of oral cancer are diagnosed i

eat promise to improve function and disability assessment in older persons. Adapted from the Late-Life FDI, this contemporary assessment
s will complete Phase II and precede Phase III commercialization. Project Relevance The LifterMate, developed by Criterion Health, Inc., wi

ent across subjects and visits without intervention of therapists or research engineers. Phase II work may include stimulator modifications t

an invaluable tool especially for neonates with limited blood volumes and/or difficult-to- established IV access. The sensor also has applica

Therefore, methods to improve cell line development, the yield of protein within the current bioreactor capacity constraints, and overall co

n of the highly pressurized and fammable samples that are necessary is not commercially available. Progress during Phase I has seen the a
to post-secondary settings. By providing teachers, advocates, or other professionals the materials needed to effectively support students' t
in Phase II; and 5) Conduct a feasibility study of the materials with professional stakeholders. The project has the potential to impact public
nd Facilitator's Guide, and a brief Digital Video. A full-scale evaluation of all products created in both phases will also be conducted.
ublic health by ultimately improving services and outcomes for youth. The purpose of this Phase I Small Business Technology Transfer (STT

stance use problems and their families, Youth LIB should contribute to public health by improving services and outcomes for these youth.
 ite will provide engaging, teen-tailored online learning activities and resources specific to teens with CF. We believe the information and ac
alth (NIMH) is to diminish the burden of mental illness through research.... the NIMH is also concerned with the speedy dissemination and
ble include gender-specific information about the relationship between alcohol consumption and risky health behavior. MSC will provide th

blic. This study projects a first year market penetration rate of 1.5 percent of those markets. PUBLIC HEALTH RELAVENCE: The US governme
ng environmental impacts of increased urbanization and energy usage. A better understanding of the current age/sex distribution and othe
scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS.
ototype Web site. This will employ research-based RBS methodologies and draw upon a RBS training web site for commercial alcohol serve
ed by instructors in oral health care training programs , and create a website for the program, offering online registration for CE credit, , acc

will provide improved care and better lives for the elderly.

ween two human plasma samples, one of which is doped with the mixture of five diabetes antigens. Specific Aim 3: Establish the specificit
und obtainable. Specific aims 3 and 4 address the novel DCP subtraction step. Here, optimal chromatographic conditions will be determine

de for the generation of new drugs to treat a host of diseases including cancer and autoimmune disorders.

hnology. Results from these experiments will provide the technical basis for achieving transposon-mediated integration and long-term expr

al for noise-induced hearing loss (NIHL). The doseBusters USA methodology involves quantifying the risk for NIHL on a daily basis by measu
cted outcome of this work is the identification of lead molecules that demonstrate macrofilaricidal activity within animal models. In collabo
in telemedicine, reduced turnaround-time healthcare, drug development, and computer-aided diagnosis.
a major positive contribution to the work of public and private researchers world wide. Scientists who are designing DNA tests to identify

et to be finalized, but likely the NCI Small Animal Imaging Resource Program at Washington University and Duke University. For mouse brai
), 1500 W rf pulses for 13C (225 MHz), and 400 W rf pulses for 1H (900 MHz). The approach will be compatible with operation in narrow-bo

etector. Each detector module (tile) constitutes a pixillated semiconductor detector that allows for direct conversion of the x-rays. In additio

or evaluation of cerebral autoregulation in clinical settings. The analysis technique developed by this project may help early detection of su

ogy for growing the company and also making the country's ultraprecision manufacturing sector more competitive. This SBIR Phase I projec
f the project is to validate the precision, accuracy, and effectiveness of the prototype of the EchoMRITM system for infants. Thus, Phase I w
e new target peptide in detecting pathogens in chronic wounds. Protease activity in samples from patients with chronic wounds occupied b

ereby revealing the presence of fungi will allow proper remedial actions to be taken.
ingival pocket to provide sustained HG delivery. The Phase I objectives are to show that HG attached to microbeads can inhibit bacterial pro
timizing SLPI production and accumulation. SLPI protein will be purified from the tobacco biomass and examined for stability and activity ag
es for this process. Using serum and tissue Iysates, we intend to show that a broad spectrum of proteins that do not fold without extensive
ciety at large. Since vocabulary development is seen as a bridge between emerging reading skills and comprehension, this project has the p
nnel current measurement technology. Such an improvement in the technology could lead to better methods for drug development and scr
portunities for young students that in turn, will have a positive infuence on the economic development and public health of our Nation. P
perform a detailed interferences analysis and demonstrate that variances in the urine matrix will not affect the SERS measurement precision
croarray products, with the new approach offering more rapid and sensitive testing. The proposed microarrays will find applications in dise

eperfused. Thus we plan to demonstrate the utility of the package at several crucial time points of infarct evolution in both reperfused and

tes, (3) determine chemical structures of active components and identify New Chemical Entities (NCEs), eliminate from consideration non-

eness into practice. The current emphasis on model programs is only one approach, and is limited by problems of scale (the whole program
ention plans. Federal funding to states for prevention planning 1) require the use of the Strategic Planning Framework (SPF), which is a data
for testing and evaluations will be both users of AAC devices and their interlocutors. Voice Gestures (VG) add expressiveness to synthetic s
following completion of the R&D program. This device will have significant clinical benefits including: (1) reduced repeat surgeries and hen

fic assays will be developed by the University of Washington using its extensive expertise and laboratory facilities in the areas of microbiolo
term vision for this technology is that it will become a useful tool for helping to arsenic-related disease among exposed populations.

as they relate to neuroscience, behavioral science, and drug abuse and addiction research. In particular, it will address the misunderstandin
the human RHD and RHce genes. Constructs containing human RHD and RHce cDNAs will be used for creation of the transgenic mice. Wh

size and cost, improve the fow sensor's accuracy and sensitivity, and add additional capabilities including fow-volume display. To bring APD
nt ES cell lines in a non-murine species, improve the transgenic efficiency in rabbits, and make the production of gene targeted rabbits pos
bition of a key enzyme of this pathway, plasma kallikrein (PK), would have significant therapeutic impact in reducing the risk of reocclusion

se II study, the aim of which will be to scale up studies into larger animal models in order to complete dose response and dosing frequency
stability and optimal shelf life in an appropriate vehicle and container, (4) Scale up for GLP manufacture of sufficient lacritin to conduct pre
promise for new insights into cancer biology. 7. Project Narrative The proposed project seeks to apply an emerging antibody array technolo
underway, such as the World Health Organizations "3 by 5" Initiative, will be providing access to HAART (e.g. highly active anti-retroviral th

Americans have the blood clotting disorder Hemophilia A, and as such are susceptible to a host of complications from chronic bleeding of t
c systems, and to explore the potential of quantitative determination of enantiomeric excess. As a longer term goal, the possibility of deter
estone: Availability of device by 10/15/2007). Specific Aim 2: Correlate gaseous and EBC ethanol concentrations measured by this device in
ed medication regimens is a major health issue in the US which costs our healthcare system over $100 billion annually. Nonadherence is a
2: Examine the cellular uptake of atherosclerotic-targeting endohedrals (ATE): Monitor and quantitate cellular uptake of the ATE by macro

e supply of the drug for testing or commercial distribution.

ghput format to facilitate future Phase III clinical trials to study the correlation between UCBf and bilirubin neurotoxicity. The successful ou
ses and necropsy. Present therapies and drugs for wound healing in diabetes and chronic wounds in general are predominantly symptom
d targets through a novel combination of dynamic combinatorial chemistry, enzymology, and nucleic acid science.

ology as a routine part of patient care. In Phase II, Sehda will add Cantonese to the system and expand the range of nurse activities for whic

upport. An advanced search engine function will also be developed to harvest potential changes and additions to the Best Practices databa
der to be placed in the eye that will reduce this pressure and preserve sight.
gy over other gene inactivation or gene perturbation technologies are that RHGP provides rapid genome wide gene perturbation in a short
mpedance and linearity tests using network analyzers, spectrum analyzers and specialized test setups. The extensive criteria for this evalua
e two competing receptor mechanisms predicts whether individuals will respond favorably to androgens or are more prone to the negative
as some liability for abuse, for the last Specific Aim, we plan to test our selected compound in preclinical models that relate to abuse liabili
time. In addition to the airport application, the portable ADRWD will be used for highways, gas stations and many other places; the techn
he boiler fue, during Phase I, additional water recycle/reuse and energy recovery was identify by our proposed technology for numerous i
o the boiler fue, during Phase I, additional water recycle/reuse and energy recovery was identify by our proposed technology for numerou
corporation into formal implementation roadmaps.
 replacement valves suffer from several shortcomings. We anticipate that the anticoagulation therapy requirements of mechanical valves c

n. These will be developed using a theory-based design and development model and will be evaluated continuously using focus groups and
rom the Social Security Administration earnings histories will be confidentiality-protected using powerful new methods that preserve priva
an Executive Order 13329 from the President of the United States placing high priority on SBIR programs directed to Manufacturing Resea
compounds against such stress. 3) Determine if neuroprotective compounds identified in Aims 1 and 2 have in vivo activity against light stre
nated as an alternative test method to the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and w

n into Census? newly-established projects that are being developed to facilitate access to confidential data through web-based application
plans for comprehensive data documentation to make specific data elements easily understood and retrievable by potential users; and (7) p
tion. In Phase II, we will develop a glyconanoparticle library by preparing a wide range of carbohydrate probes conjugated on nanocrystals w

ns. By partnering with Shriners, ADA will establish an early, working relationship with the nation's leading provider of child's prosthetic car

technology. The system we describe herein is designed to fully exploit the spatial, temporal and thermal engineering parameters necessary

Phase I is to build upon this foundation of work in the area of sleep medicine, and extend the development of AMP platform to accommod
for patients with loud snoring and OSA.

ed from the heelstick of a newborn using a microfuidic lab-on-a-chip.

edical devices that will allow full utilization of this new capability. The rising cost of American health care continues to plague public and pr

cy in relevant in vitro functional cellular models. 3. Determine efficacy and potency in nude mouse xenograft tumorigenicity models. At the

or early detection of lung cancer could provide a cost-effective screening approach, and in concert with CT scanning would enable a viable s

MGH), which has an active brain tumor clinical group. The Phase II portion will assess clinical efficacy at the maximum tolerated dose (MTD

purpose of the proposed project is to relieve symptoms and prevent death from asthma, especially among the hardest hit groups like Afric
the extraction, reaction, and separation steps. The overall goal of this multi-phase SBIR project is to develop, validate, and commercialize a
nd late stage clinical studies for pain therapeutics with new mechanisms of action.
neously recording EEG/EMG and piezo signals in two strains of mice that have different sleep patterns. The Phase I study will produce a uni
wn for its effects on cognition and locomotion. This versatile and habitable SmartCage will provide visual-discrimination cognitive testing a
roof of principle focus because they have been extensively studied in preclinical and clinical trials for the treatment of damaged myocardiu
mplant associated infections. Branched IFBM's containing binding modules for all three classes of antibiotic would be assembled and exam
Affinergy's existing BMP-2 and osteoblast binding sequences and the newly identified TCP binding peptides. These candidate bi-functional l
eoprogenitor cells. Finally, to be most effective as a timely point of care device, the entire process from drawing a marrow aspirate to re-im
l in the area of aging research, for healthcare ambulatory assessment and for long-term unobtrusive monitoring of elderly populations at ri
s established in vitro then secured beneath a gingival fap with a defined area of membrane exposure. Healing will be measured clinically an
rototype transgene will enhance development and characterization. Effective bone graft materials for co-delivery with the replication-defe
r-interface and content feedback provided by medical experts, students and teachers; 3) scale up assessment by raising the number of scho
build distributed autonomous monitoring systems. The project will use a wireless network of sensors to build the infrastructure for continu
utomatic personal synthetic voice construction, and c) established clear expectations for the quality of synthetic speech prospective users

of people each year. Opioid analgesics remain the standard of care for moderate to severe, acute and chronic pain, and are prescribed for m

es. These tissue expanders will not swell until sufficient healing has occurred for tissue expansion. These tissue expanders will not require
project Milestones will provide sufficient justification to proceed with a Phase 2 proposal, where the Specific Aims will be to: integrate the
tions and 20,000 deaths annually in the U.S. alone. The continued emergence of new strains (such as infuenza A H5N1) in East Asia highlig
ge of fuid media and the availability of oxygen. Metabolic waste must be removed and nutrients need to be brought in. In the case of long
n the Phase II program, we plan to increase the number of pixels in the array, increase the functionality of each pixel, and reduce the size o
s proprietary photon counting detector array technology.
nced Photon Source (APS), Argonne National Laboratory, Chicago, IL, to demonstrate their performance superiority compared to current st
sely pinpoint location of hydrogen atoms and help to define molecule's structure. Advancements in neutron detector instrumentation will
al optical imaging using fuorescent lifetime tomography with a suitable contrast agent will provide a baseline for the performance of the Ph

e facility and would help to advance research of protein mechanisms as well as drug design.
ntence or database entry to form a novel hypothesis and cure a disease. Total recall approaches to fact extraction make that all the more lik

cupation with the drug (perseveration) and negative affect (anxiety) as the result of withdrawal from the drug. Both behaviors may then dri

s developed a sophisticated computer-aided image analysis system for a variety of medical imaging applications. Almen Labs' Computer-Ai
acious therapy agents to attack malignant melanoma. The development of targeted a-therapy for malignant melanoma is attractive since th
treatment of skeletal metastases.
uch as AlphaSniffer's SPR-CPI platform be developed that can analyze the cellular functions of protein and carbohydrates in their natural st
utoimmune diseases.
ach year. Optimal treatment of these patients requires a low-cost but highly sensitive diagnostic method of detecting drug-resistance mutati
wild-type protein. Enhanced sensitivity will also be obtained by utilizing MASSIVE-PRO to scan for missense mutations in K-Ras and other g
ASSIVE-PRO assay will also be improved so that it can provide specific sequence information about mutations in the NF1 gene. Advanced te
nology using emerging miRNA biomarkers to develop a PrCa molecular diagnostics assay with superior sensitivity to the standard cytopath
lyzing the assay results and to assist in clinical interpretation of the results. The final outcome is to launch mutation-specific Analyte Specifi

ilized KOR and other GPCRs. A number of receptors and other membrane protein appear to require interactions with cholesterol in the me
n the United States.

mains a significant cause of morbidity and mortality. A small molecule hepatocyte growth factor mimetic that is hepatoprotective is of trem
 hat increases the preservation time of donor lungs will have tremendous clinical benefits.
s that can be advanced towards clinical development. Additional synthetic work based on the recent significant improvement in activity, in
tinal tract, and heart. Scleroderma affects approximately 400,000 people in the United States every year. There is no known cure for Sclerod
ructure, molecular modeling, and medicinal chemistry approach to increase the potency of Ang797. The goal of this application is to evalua
egulatory studies indicates that acute systemic administration of Refanalin is safe and well- tolerated. Long-term (3-month) safety studies o

immunological status by comparing antitumor efficacy of selected S. typhimurium auxotrophs in nude-mouse and immunocompetent-mo

7 peptide for treatment of fungal infections.

transepidermal water loss (TEWL). The Phase I success criteria are the identification of a PG analog that inhibits keratinocyte growth by = 5

uate the protective effects of ABC294640 in a model of oxygen-induced retinopathy. 2.) To evaluate the protective effects of ABC294640 in
ntaneously diabetic non-obese diabetic (NOD) mice, which exhibit destructive autoimmune pancreatic insulitis. Transplants will be done in
tion. Second, chimeric proteins can be displayed singly or in a combination on the surface of any biotinylated cell at desired levels in a rapid
t of cancer represents an alternative therapeutic approach to classic chemotherapy and radiation treatment, and promises to yield a more

anticipated that the Crystal Finder(tm) microscope workstation will dramatically impact the successful identification of difficult-to-detect pr

sociated with misinterpretation of this information. In addition, it is anticipated that the new visualization system will have educational imp
ates, such as the opioid tolerant patient, the display can provide accurate predictions for outliers beyond the normal population, possibly r

a via a combination of bird movement and local amplification through mosquitoes. This project aims to develop automated fight activity s
and sell it to the EPA, USGS, researchers in academia, as well as industrial concerns interested in compound screening and environmental m
ymer-drug(s) formulations on a representative tracheo-bronchial stent. The proposed drug-eluting tracheo-bronchial stent is designed to tr

sample tracking database application was planned with the input of prospective customers using Agile Software methods. During Phase 2 o
et for building toxicological computational prediction models. We believe that such a knowledge base can facilitate research in the pharmac
d optimally as a liquid in a mouse inhalation model. The studies proposed in this application are designed to further development of a
75% of the ~40 lysosomal storage disorders affect the brain. The mainstay of treatment is Enzyme Replacement Therapy (ERT). However, E

roach to reduce significantly the frequency of hypoglycemic occurrences. Our approach is noninvasive, thereby avoiding confounding issue

R Phase II study is to provide the optimal regimen of MAPC transplantation in an HI model that addresses the feasibility, safety and efficacy
d their staff treating the animals. If this formulation is successful, it could be used for other laboratory animals such as rabbits, hamsters, gu

nalyzed. Further development of VEL-PCR will be performed in Phase II to adapt it to the detection of other important pathogens.
 quirements for automated testing and increased efficiency of manual testing, additional improvements will be explored in Phase II. These
systemically. The CES approach combines automated solid-phase peptide synthesis of linear precursor peptides, with enzymatic cyclization

ood of success is high (we know the drugs work; we are only changing the delivery route), because the costs of clinical trials can be reclaim
sion of the underlying disease. The purpose of this project is to develop a sustained release injectable formulation for this drug that will bo
ma clearance assays and 2) to determine the therapeutic effects of higher-molecular-weight derivatives of TGF-a peptantagonist on bleomy
g. In addition, it will allow for scientific and technological benefits by improving our understanding of AD and catalyzing the development a
monitoring, and therapeutic selection. Avid Radiopharmaceuticals is an experienced leader in developing new commercial PET tracers, is c
the level of muscle contraction using a novel functional assessment paradigm involving a tactile stimulus-activated polysynaptic spinal refe
rize. AK295 will be a "first in class" drug for the prevention of axonal degeneration and CIPN, an indication for which there are currently NO

te, and mild TBI that will allow correlation of biomarker levels to clinical measures of injury severity, disease progression, and outcome. Th
in practice (e.g., self- report measures, by their nature, do not refect how the patient feels and functions in day-to-day activity). The propo
al Movements for the Identification of Neurological disorders in Infants (GEMINI) system, a low-cost tool for objectively and automatically a

assurance, BCR Diagnostics has developed unique living microorganisms that promptly send fuorescent light signals when the sterilization

omplexity of the engine's hardware from the biological end user.

nd non-chemical addictions will benefit the overall public health of our nation in three ways: 1) improved recovery outcomes for those seek
d that the screening and early detection of mental disorders and the reduction of health disparities be priorities in the transformation of th

for adolescents suffering from panic disorder.

nd commercialize a Microfuidic Reconstituted Tissue Device that will enable more physiologically relevant cellular assays in a high through

em mechanics, electronics and software will be refined to improve safety, ease-of-use, fexibility and dynamic performance. Clinical perform
rom a restrained pig vs blood sampled automatically from a mobile pig. Another validation study will evaluate comparisons with human da

y advantages compared to the existing chemical ones. They are very selective in the reactions they perform, are recyclable and biodegrada
oach. If the handheld BFI is able to reliably detect malignant skin lesions, it will improve the quality of life for tens of thousands of dermato
cy (RF) ablation, and percutaneous lesion removal systems. This research will produce a viable platform for MRI-guided diagnostics and the
eir impact. Phase I, Specific Aim 4b will complete software practice changes needed for implementation in Phase II. Phase I, Specific Aim 5 i
their template can be activated. Pyrophosphorolysis, the reverse of the DNA polymerization reaction, therefore activates the polymerizatio
es than would otherwise be possible. Two other types of WGA are currently being commercialized for research applications: 1) methods de
t, detect and control hypertension. The technology from this project is expected to improve clinical diagnostic methods involving physiolog
se knockout strains with PM technology to study the function of genes that are unique to the metabolism and drug resistance of this genus
has had significant discussions with physicians and support staff in both the civilian and military markets and received extremely positive fe
hways associated with hemorrhage and improved treatment. A phase II study will further characterize the anti-infammatory signaling mech
use HAF as an intracavitary hemostatic agent in cases of non-compressible hemorrhage. Phase II studies will define the adhesive and coag
ar year, and the number of years prior to diagnosis/interview. These temporally-detailed exposure estimates are especially valuable for dise
ucing these disparities.
we will evaluate the performance of each of the antibodies side-by-side and select the best performing carrier for further commercial deve
se. Lyme disease, the most common vector borne infectious disease in the United States affects multiple organ systems. Although pro
e white-footed mouse.

inical sera. As TL1A will likely mediate various pro-infammatory and pro-apoptotic responses in the body, the commercial value of a well c

egment imaging which will make the benefits of ophthalmic OCT imaging available to a much wider class of subjects, including bedridden a
to HIV care worldwide. BioScale's proposed inexpensive, rugged and easy-to-use diagnostic for measuring viral load with rapid time- to-resu

h should find broad applications in the general study of cell and molecular biology as well as to high throughput screening of drug candida

ristics, and on producing portable, user-friendly software. The anticipated commercial offering consists of (i) software components to be lic
but also in other areas such as colorectal carcinogenesis, intestinal infections, celiac disease, irritable bowel syndrome, prebiotic and probio

e used effectively especially given the heterogeneity of the Black radio audience.

re also needed for a wide range of applications including food and water safety, bioreactor analysis and sterility assurance, and environmen
ccessfully accomplish the proposal Phase II objectives. The relevance of the glucose-sensing technology developed by BioTex, Inc. to public

ftware for use specifically with manual patch clamp setups and for exploration of the potential benefits of using machine learning via expe
00, the total market for such a device is estimated at up to 300,000, i.e., 10% of low vision persons in the United States. The commercial ve

nd therefore, is a reasonable target for therapeutic intervention in RA patients. VEGF inhibitors have been tested in humans and have been

wledge of activity and effective lifetime of AMNC's as a function of structure and composition. 4. Initiating in vivo performance and biocomp
argeted antimicrobial therapy against cariogenic bacterium Streptococcus mutans. Phase III follow up works will include human clinical tria

d pharmaceutical research which involves drug to protein binding. The proposed project is a method and apparatus for rapidly characterizi

tency via dose response assays and tested for their effect on chaperone induction, the enhancement of proteasome activity and spectrum
us to validate DJ-1 up- regulation as a pharmacological target for PD and to develop chemical probes to investigate the actions of DJ-1 in ce
to allow targeting ligands to direct the particle inside tumor cells. In specific aim 3, this optimized formulation will be tested in a mouse mo

th. In summary, we hypothesize that multiple low dose injections of Saneron's human umbilical cord blood cells mononuclear fraction (HU
endent. Type I (usually juvenile-onset) insulin-dependent diabetes mellitus (IDDM) results from autoimmune damage and subsequent loss

pment of minimally invasive therapeutic regimes for the treatment of cancer. The intent of this project is to investigate and develop a nove
ell as provide a platform for future development of therapeutic strategies for the treatment of cancer.

ptides of NF-?B signaling pathway. The combination of phage display technology with cell-based HTS will transform phage display technolog
e to identify new targets for therapeutic intervention, and the development of increasingly relevant paradigms for drug discovery. As a resu
vide basic researchers with preferred, cost-effective alternatives to existing commercially available reagents. The ultimate goal of the propo
to mass casualties as a result of a nuclear power plant accident, terrorist detonation, or other localized radiological disasters.

etic particles to isolate and concentrate viruses (HIV-1, HBV and HCV) from human serum or plasma samples as a simplified sample prepara
ransfection system to validate potential ventricular CM-specific promoter's activity in hESC-derived CMs increases the likelihood of accomp
ited States. This system is developed to address these issues.
health clinics, field and point-of-care sites. Centice, Inc. and Oxonica, Inc. plan to jointly develop a novel immunoassay technology platform

d prototype libraries proposed may identify distinct potential leads in one, or possibly both, the antibacterial and antiviral arenas. Dependi
kB signalling pathways. Our goal will be to identify analogs with a better apparent therapeutic index than the current leads. The antitumor a
Then the interaction between cold perfusion time (24 and 48h) and warm ischemia time (up to 60 min) on porcine islet isolation parameter

ave estrogenic/anti-estrogenic activities that severely interfere with normal estrogen actions to produce adverse effects on many behaviora
ay identify novel compounds with therapeutic potential for the treatment of retinal NV. This proof-of-concept study will allow future Phase
dies have shown that intravitreal injection of K5 prevents the development and arrests the progression of retinal vascular leakage in the ox
mmercialization of this new compound. This project has potential to develop a novel drug for treatment of DME. These Phase II studies rep
ubjects. The point-of-care diagnostic to be developed here could revolutionize clinical practice by allowing the first medical provider in cont
or. The overall goal of the Phase I and Phase II project is to validate the system and perform clinical testing of an integrated micro-scale gen

rican-American breast cancer patients (AABCP). Stress will be placed particularly on issues of cultural competency. The product will enable

roposed research aims to develop improved diagnostic methods for rheumatoid arthritis and other autoimmune diseases which affect over
ys in the fight against T1D.

g motor features, olfaction, sleep parameters, voice modulation, and other relevant neurological signs. A patient database will link clinical g
o allow for automated control, data collection and analysis on large number of modules at the same time. We will also assess the feasibility
nd tools to assist with caregiving should ultimately improve outcomes for both informal caregivers and their loved ones, including improved
tent of modules 2 through 6, those for evaluating educational interventions based on the work by Holloway et al. (1983; 1988) and questio

ammation associated with amyloid deposition in Alzheimer's disease. Pr Novel Intervention for Amyloid-Induced Neuroinfammation Cerbro
ouse models of colitis treated with COG112 should have less disease than their untreated counterparts. So we propose to directly measure
isease and lessen the burden on society in caring for those who cannot care for themselves. Success in development of new therapeutics w

his grant might fill the tremendous medical need for a restorative therapeutic for MS.
ed a novel therapeutic target for MS. Considering the early age of onset, size of the patient population, debilitating nature of this disease, a
for small bone repair, 3) establishing resorption rates in vivo, and 4) evaluating bone regrowth in the defect. Positive outcomes will lead to
-surgical fuid accumulation. This research project will include finalizing the product specifications including both product formulation and
f a vaccine to cover more people. That is the goal of the proposed research.
e a complete perception training system with demonstrated effectiveness that will help L2 learners to accurately process English in real life

which is environmentally attractive and cost effective. The process will also keep potential biological contaminants out of the environment.

on the puerarin structure.

f time. The "personal Exposure Monitor" proposed here for the analysis of exhaled breath will be person portable and can be accommoda
or use across the Self-Management Modules. Specific Phase II tasks include final content development and review by several expert groups
y treatment is also used to reduce domain size. Various mesh and multigrid options will be explored to expedite evaluation of the fuctuati
be of great benefit for the synthesis of corneal wounds, caused either by trauma or induced by surgery.

es of oral cancer are diagnosed in the United States; for which the basic treatment is surgical excision of hard and soft tissues of the face, l

I, this contemporary assessment technology will fill a critical void for a practical and psychometrically superior system that is not currently a
ped by Criterion Health, Inc., will provide a low-tech solution to a serious and often costly problem for individuals in wheelchairs, who cann

nclude stimulator modifications to simplify instrumentation and to stimulate a larger number of muscles, mechanical modifications to the T

cess. The sensor also has applications in transfusion medicine and in the defense against chemical warfare agents and cyanide poisoning. H

pacity constraints, and overall cost and efficiency of these processes are highly desirable.

ess during Phase I has seen the approach be largely implemented in a specialized laboratory setting and the results obtained thus far provid
to effectively support students' transition to post-secondary life, this tool ultimately will increase services and improve outcomes for young
as the potential to impact public health by helping drug abuse clients build healthy relationships through confict resolution principles. The
es will also be conducted.
usiness Technology Transfer (STTR) proposal is to develop and evaluate the Family Engagement Training Program (FETP)-a Web-based innov

and outcomes for these youth.

e believe the information and activities contained in CFFONE will improve users' knowledge, attitudes, and practices around CF and we hyp
h the speedy dissemination and use of this knowledge through scientific communications and public education. There is a general need to
th behavior. MSC will provide this much- needed gender-specific approach to alcohol prevention, providing teachers with instructions for i

H RELAVENCE: The US government spends over $100 billion a year on AD and, as of 1996, the average lifetime cost of care was $175,000. A
nt age/sex distribution and other characteristics of the population will facilitate planning and resource allocation for services such as health

ite for commercial alcohol servers. We will then test both the usability and effectiveness of the web site in increasing knowledge, concern,
ne registration for CE credit, , access to current research, and communication with other users about the program in preparation for marke

fic Aim 3: Establish the specificity of the affinity capture reagents that are generated as part of the process.
hic conditions will be determined for the efficient removal of phage that binds to targets present in both of a pair of samples. In addition, t

d integration and long-term expression in hematopoietic stem cells, the cell population that will be targeted for FA gene therapy, and will al

or NIHL on a daily basis by measuring actual protected noise exposure. The evolution of this technology, including the addition of communi
within animal models. In collaboration with agencies that have demonstrated a commitment to global health equity (such as the Gates Fo

designing DNA tests to identify or discover the function of important, disease related genes will be able to 'test their tests' in a computer, w

Duke University. For mouse brain MRS, the H S/N 1 of the proposed Phase II double-tuned cryogenic platform at 11.7 T is projected to exce
tible with operation in narrow-bore (NB) magnets at the highest fields anticipated in the coming decade - at least 1.0 GHz. The proposed w

nversion of the x-rays. In addition it uses highly advanced next generation integrated circuits in order to produce digital x-ray CT images wh

ct may help early detection of subjects at high risk of stroke. The quantitative measurements derived from this innovative technology can a

petitive. This SBIR Phase I project will explore the feasibility of an innovative technology for the ultraprecision diamond machining of the m
stem for infants. Thus, Phase I will entail developing and validating both the 4 kg research prototype and the 11 kg commercial prototype o
with chronic wounds occupied by 105 or more pathogenic bacteria (infected) will be compared to those that are not (non-infected). In add

crobeads can inhibit bacterial proteases from the three red complex pathogens in vitro and to examine their effect on a P. gingivalis biofilm
mined for stability and activity against proteases. Following successful Phase I purification of biologically active SLPI from tobacco, producti
at do not fold without extensive manipulation in vitro will do so quickly and efficiently with this system. Our third aim is to streamline the p
prehension, this project has the potential to help many students expand their literacy skills. The instruction would be used to help them lea
 ds for drug development and screening and offer the capability to test experimental drugs' effect on ion channels, and thus on many proce
nd public health of our Nation. Page 1 Principal Investigator: Graf, Karen Narrative Our Nation is a highly industrialized society and science-b
the SERS measurement precision. Commercial: EIC Laboratories will commercialize the technology by manufacturing the SERS sensors and
rrays will find applications in disease detection/progression, analysis of protein expression levels, protein analysis for small samples such as

evolution in both reperfused and non-reperfused myocardial infarction models. To aid in coregistration of MRI and histology, based on the s

minate from consideration non-NCEs and NCEs which are inappropriate as drugs, and (4) determine minimum inhibitory concentrations an

ems of scale (the whole program is often not a feasible focus for many settings), implementation fidelity, and adaptation to different contex
Framework (SPF), which is a data driven planning model, and 2) the use of AOD National Outcome Measures (NOMs) for determining comm
add expressiveness to synthetic speech for individuals who cannot use their biological voices to communicate easily with family, friends and
educed repeat surgeries and hence, reduced local recurrence, (2) reduced tissue removal, which translates to cosmetically-superior lumpec

ilities in the areas of microbiology, chemistry, environmental science (atmospheric pollutant detection and characterization), etc.
ong exposed populations.

will address the misunderstanding among many groups about the nature of addiction as of biologically based brain disorder. The proposed
ation of the transgenic mice. When mice carrying the transgenes have been identified, their erythrocytes will be characterized for expressio

fow-volume display. To bring APD into commercial production (our long term objective), further refinements are necessary. After that, clini
tion of gene targeted rabbits possible.
reducing the risk of reocclusion and reinfarction in patients with mycorcardial infarction (MI) who have undergone fibrinolytic treatment. I

response and dosing frequency analysis and to perform formal pre-clinical safety/toxicity and biodistribution studies, in preparation of an
f sufficient lacritin to conduct preclinical trials. Moreover, evidence of anti-infammatory effects will also be documented. The goal for Phas
merging antibody array technology for the detection of cancer-related splice variants from complex biological samples. The continued deve
g. highly active anti-retroviral therapy) to millions of patients in these areas of the world over the next several years. It is in such resource p

ations from chronic bleeding of the joints to life threatening blood loss due to traumatic injury. This proposal describes a plan to produce an
erm goal, the possibility of determining analytes chirality of using known chiral modifier will also be examined. The fundamental knowledge
tions measured by this device in human subjects with concentrations found in venous blood and document the absence of oral fuid conta
on annually. Nonadherence is a major cause of morbidity and mortality. It can result in a public health threat if, for instance, a patient fails
ular uptake of the ATE by macrophages foam cells compared to other cell types. A profound need exists for more efficient, targeted, an

neurotoxicity. The successful outcome of this study will be a unique assay for UCBf that more accurately gauges the risk of bilirubin-media
 eral are predominantly symptomatic, empirical, unpredictable, and largely ineffective The ACT1 peptide potentially offers a mechanistically

range of nurse activities for which the system can translate. Sehda will conduct a similar set of activities as in Phase I but on a much larger

ons to the Best Practices database content. An experimental test of the full online ESSP assessment and prevention package will be conduc

ide gene perturbation in a short period of time of a few months. RHGP can cause either gene inactivation through severe knockdown of ex
extensive criteria for this evaluation have been delineated in preliminary work, and the project target is to determine the performance leve
are more prone to the negative consequences of androgens. This hypothesis will be tested within the confines of two specific aims. The fi
models that relate to abuse liability. These models are 1) behavioral sensitization; 2) withdrawal signs with cessation of repeated treatment;
nd many other places; the technology related with laser rangefinder, IR, Radar, etc. will be used for railway defects inspection and missile d
osed technology for numerous industrial emission streams. Further, this transport membrane condenser can offer a truly green agricultura
oposed technology for numerous industrial emission streams. Further, this transport membrane condenser can offer a truly "green" agricul
uirements of mechanical valves can be substantially reduced by using a polyurethane trileafet valve. We further anticipate that a polyureth

tinuously using focus groups and advisory panel reviews. The core content and courses will also be evaluated in two sets of field trials: an in
ew methods that preserve privacy while allowing many important statistical analyses to be performed combining the protected SSA and ge
directed to Manufacturing Research and Development.
e in vivo activity against light stress using a mouse model. The feasibility of our approach will be validated if we can identify novel cytoprot
ative Methods (ICCVAM), and will allow us to determine how well Ocuscreen meets ICCVAM performance standards. Phase II work will inv

through web-based applications that restrict the reporting of results; and (8) prepare plans for MedRIC?s computer infrastructure needed
able by potential users; and (7) produce plans for the computer infrastructure needed for data storage, linkage and extraction.
bes conjugated on nanocrystals with different emission wavelengths, develop magnetic glyconanoparticles for use as MRI reagents, and dem

provider of child's prosthetic care and equipment. Throughout, ADA will maintain focus on commercial viability by constantly working with

ngineering parameters necessary to dissociate pancreatic tissue, thereby maximizing cell yield and viability in a consistent and repeatable m

t of AMP platform to accommodate the range of potential applications and to take the next step in the evolution of the AMP product in a c

ontinues to plague public and private payers. This is prompting the examination of new ways for people to manage chronic conditions for t

ft tumorigenicity models. At the conclusion of this Phase I, we will have identified a mouse Mab (or Mabs) with the optimal in vitro and in

scanning would enable a viable strategy for reducing the severe mortality rate of this disease.

e maximum tolerated dose (MTD) or the highest dose level reached in this Phase I study.

the hardest hit groups like African Americans, with a CO2 propellant inhaler that is as effective as and less expensive than currently availab
p, validate, and commercialize a new, more cost-effective method for artemether production that utilizes supercritical carbon dioxide in an

Phase I study will produce a uniquely engineered DiscTreadmill prototype apparatus with special software. This innovative and versatile to
discrimination cognitive testing and enable integration testing of cognition with other aspects of behavior, such as sleep and wake activity, t
eatment of damaged myocardium and skeletal muscles. However, Affinergy's modular IFBM peptides developed for myoblast engraftment
c would be assembled and examined for efficacy in vitro and then in an implant infection model in vivo. Infection surrounding metal ha
. These candidate bi-functional linker peptides will be tested for their ability to bind BMP-2 and osteoblasts on TCP matix, while retaining B
wing a marrow aspirate to re-implantation of the filtered osteogenic cells and growth factors should be as quick as possible (ideally, less tha
oring of elderly populations at risk of falling. The research and resulting device will provide the following benefits: 1.Enhance the ability to
 ing will be measured clinically and histologically where rate of exposed membrane coverage by epithelium will be the primary outcome. Th
elivery with the replication-defective adenovirus system, or with plasmid DNA in liposomes, will be identified from common bone graft ma
nt by raising the number of schools involved, widening the school profiles through the inclusion of inner city schools, and tapping into outr
uild the infrastructure for continuous Particulate Matter monitoring. Besides having no need for expensive and cumbersome connection pro
thetic speech prospective users of this technology can expect to obtain with their personal synthetic voice.

nic pain, and are prescribed for millions of people each year. The use of opioids leads to adverse effects including opioid-induced bowel dys

ssue expanders will not require multiple visits utilizing exterior equipment such as pumps and valves. These tissue expanders will also be e
fic Aims will be to: integrate the sample preparation and protein array functions into a self-contained, integrated, injection-molded test car
enza A H5N1) in East Asia highlights the need for rapid, comprehensive surveillance and diagnostic tools. Akonni's technology and product s
be brought in. In the case of long term cultures where electrical or optical data recording takes place from the living tissue be it neurons, he
each pixel, and reduce the size of each pixel. Title: High throughput and high sensitivity multi-well plate reader Project Narrative: The multi

periority compared to current state-of-the-art scintillator screens. During the proposed Phase I/Phase II research, we will undertake efforts
n detector instrumentation will provide better capabilities define these structures and help to recognize the molecule's purpose.
ne for the performance of the Phase II prototype.

action make that all the more likely an outcome. The dominant paradigm in text mining is to treat the text like a database. But researchers

ug. Both behaviors may then drive drug seeking to alleviate these symptoms and thus are leading candidates as targets of relapse preventi

ations. Almen Labs' Computer-Aided Imaging System (CAIS) provides extensive tools to identify objects of interest or concern such as breas
t melanoma is attractive since the short particle pathlength of a-emitters is particularly well match small clusters of disseminated tumor ce

carbohydrates in their natural state, without the use of labels that often change the way these biomolecules behave. The research propose

detecting drug-resistance mutations in HIV-1 genes in patients initiating or undergoing drug therapy. Currently, DNA sequencing of the mu
e mutations in K-Ras and other genes associated with early CRC tumorigenesis. The results obtained from MASSIVE-PRO will be validated b
ns in the NF1 gene. Advanced technologies based on several innovations which can significantly reduce the number of PCR and cell-free tra
sitivity to the standard cytopathological prostate biopsy. The goal of this project is to improve cancer diagnostics by developing an integrate
mutation-specific Analyte Specific Reagents (primers, probes) and apply for FDA approval as an In Vitro Diagnostic Assay. The availability of

ctions with cholesterol in the membrane in order to be fully functional. However, cholesterol is notoriously difficult to solubilize in the mice

at is hepatoprotective is of tremendous clinical benefit.

ficant improvement in activity, in combination with assessment of inhibitory activity of new analogs towards in vitro cellular and kinase targ
ere is no known cure for Scleroderma and the exact cause remains unknown. The objective of this application is to evaluate a lead small-m
oal of this application is to evaluate the anti-RA effects of Ang797 and its analogs on anti-angiogenesis activity in different cell lines, to dete
term (3-month) safety studies of Refanalin undertaken by the National Institutes of Health NIH Rapid Access to Interventional Developmen

use and immunocompetent-mouse tumor models. In the Phase II grant, the effective antitumor bacterial strains will be further developed

hibits keratinocyte growth by = 50% in vitro and demonstration of a significant (p = 0.05) reduction in proliferation and/or infammation wit

tective effects of ABC294640 in a model of laser-induced choroidal neovascularization. 3.) To complete cGMP synthesis and IND-directed to
litis. Transplants will be done in the presence of rapamycin a pharmaceutical agent used in the clinic for the prevention of graft rejection. W
ed cell at desired levels in a rapid (< 2 hrs), efficient (100% of the targeted cells), and durable (t1/2= days to weeks) manner without compr
nt, and promises to yield a more definitive solution based on a true molecular approach to cancer. ApoImmune's novel immune system-bas

tification of difficult-to-detect protein crystals in crystallization trials. The unique features and superior performance of the Crystal Finder(tm

system will have educational impact, as it will provide a clear demonstration and interaction of variables to both novices and experts alike.
he normal population, possibly reducing risk of respiratory depression and inadequate analgesia. Optimizing the display will bring intelligen

velop automated fight activity sampling technology by adapting current traps with electronic sensors. Public health vector control specialis
d screening and environmental monitoring/remediation. This project will result in a fully developed microarray for ecotoxicology testing i
-bronchial stent is designed to treat obstructions caused by lung cancer. It is beneficial for public health because it is predicted to improve

ware methods. During Phase 2 of the project, the technology risk of manufacturing this novel liquid storage container with unique and per
acilitate research in the pharmaceutical and drug discovery fields and will be highly useful to many researchers in these areas. An efficient
ned to further development of a human monoclonal antibody to treat chronic Pseudomonas aeruginosa lung infections of CF patients. At p
ment Therapy (ERT). However, ERT is ineffective in the brain, because the enzymes do not cross the blood-brain barrier (BBB). The present

reby avoiding confounding issues associated with biocompatibility and infection that plague implantable biosensor technologies.

he feasibility, safety and efficacy criteria within the standards of FDA regulations, thereby realizing a smooth translation of this cell based th
mals such as rabbits, hamsters, guinea pigs, cats, dogs, pigs and non-human primates with appropriate dose adjustment. The novel long acti

r important pathogens.
 ll be explored in Phase II. These will include elimination of the residual occlusion effect at 250 Hz and increased output. These can be accom
tides, with enzymatic cyclization using a recombinant thioesterase (TE) domain derived from the relevant Non Ribosomal Peptide Syntheta

ts of clinical trials can be reclaimed under the tax provisions of the Orphan Drug Act, and because we have developed similar products befo
mulation for this drug that will both increase its effectiveness and reduce its side effects
TGF-a peptantagonist on bleomycin-induced pulmonary fibrosis in mice. The methodologies will include biochemical, histological and semi
nd catalyzing the development and evaluation of novel therapies for this devastating disease.
new commercial PET tracers, is collaborating with world-experts on VMAT-2 imaging, and is first company with a promising F lead compoun
ctivated polysynaptic spinal refex and by (ii) a histomorphometric analysis of healthy regenerated axons in the distal nerve segment of the
for which there are currently NO drugs on the market. An indication for CIPN will likely lead to trials in other neurological disorders such as

e progression, and outcome. The accuracy with which the biomarkers can discriminate magnitude of injury, and patients that are likely to h
in day-to-day activity). The proposed technology offers a novel method for overcoming present limitations in accurately assessing the functi
r objectively and automatically assessing infant GMs in hospital and non settings. The GEMINI system will exploit Barron Associates' recent

ght signals when the sterilization process is inadequate.

ecovery outcomes for those seeking such alternative recovery options; 2) a better quality of life for consumers seeking to recover from the
orities in the transformation of the nation's mental health system. The proposed research will address these two national public mental hea

cellular assays in a high throughput, automated format.

mic performance. Clinical performance will be assessed with 36 healthy older adults randomized into two different 16-week PRT groups stra
ate comparisons with human data. For example, one advantage of using a pig for pharmacokinetics studies is their acceptance of solid dos

m, are recyclable and biodegradable, and operate under green environmentally friendly conditions.
or tens of thousands of dermatology patients in the United States alone.
r MRI-guided diagnostics and therapeutics that will allow more accurate and useful diagnosis and therapy of breast tumors that are not visi
Phase II. Phase I, Specific Aim 5 implements key features of LabmatrixTM to optimize the ease of implementation in varied bioscience labo
efore activates the polymerization of DNA only if the 3'end is matched to its target; hence the name pyrophosphorolysis-activated polymer
arch applications: 1) methods derived from the polymerase chain reaction and 2) multiple displacement amplification (MDA). Rubicon Gen
stic methods involving physiological fuids such as blood and urine, which need to be processed quickly in advance of a clinical testing proto
and drug resistance of this genus. If successful, this aspect of the project will aid efforts toward the development of new or more effective a
nd received extremely positive feedback regarding the value and need for this device. A full time business development person is now requ
anti-infammatory signaling mechanisms associated with the effect of the solution, and study tissue distribution, cytotoxicity, and evaluatio
ill define the adhesive and coagulation properties of the compound in an intracavitary hemorrhage military-relevant animal model (pig), st
s are especially valuable for diseases with long induction periods, such as cancer, and will allow environmental epidemiologists and risk ass
rier for further commercial development in Phase II. In Phase II, we will scale-up the most efficient system and broaden its utility for the pro
ple organ systems. Although prompt diagnosis and treatment prevents or limits serious injury to the systems affected, current serodiagnosti

the commercial value of a well characterized ELISA is undoubtedly high. Moreover the discovery of elevated soluble TL1A in certain infamm

f subjects, including bedridden and infant human patients, as well as animals of all sizes (from mouse to horse) used in biomedical and vet
viral load with rapid time- to-result would revolutionize HIV monitoring and infant diagnosis in the resource-scarce regions most impacted b

ghput screening of drug candidates. Reporter genes are essential to accurately measure specifc gene activity . In combination with fuoresc

i) software components to be licensed to AAC vendors and (ii) a service consisting of collection and processing of recordings and creation o
syndrome, prebiotic and probiotic therapies. This proposal involves the first time use of a sophisticated and highly reproducible bacterial fi

rility assurance, and environmental microbiology. This project focuses on developing a total system for microbial identification using predic
eveloped by BioTex, Inc. to public health lays in the need to find therapeutic means to minimize or even eliminate the devastating effects of

using machine learning via expert training in other applications. In Phase II we propose to develop the proof-of-concept software into a use
United States. The commercial version of the Smart Telescope will significantly increase mobility and independence for persons with visual

ested in humans and have been shown to delay the progression of the disease. Our overall goal is to create a long acting VEGF inhibitor tha

n vivo performance and biocompatibility evaluations. Approximately two million hospital-acquired infections are reported annually in the U
s will include human clinical trials to evaluate the safety and efficacy of these STAMP-based therapeutic agents.

pparatus for rapidly characterizing proteins for their binding properties and post-translational modifications. This characterization will be a

oteasome activity and spectrum of activity against a panel of mis- folded proteins (SOD1, polyQ huntingtin, tau, amyloid Aa, and prion prot
estigate the actions of DJ-1 in cellular and animal systems. Parkinson's disease is the second most common neurodegenerative disease, affe
tion will be tested in a mouse model of lymphoma to determine efficacy, safety, and pharmacokinetics in a small animal model. The propos

d cells mononuclear fraction (HUCBC, trademark name U-CORD-CELL") into transgenic PSAPP mice will provide a rescue of behavioral defici
ne damage and subsequent loss of the islet beta (a) cells. Islet cell transplantation has recently been shown to be an effective treatment bu

o investigate and develop a novel therapeutic device (CryoInjectTM and CryoPelletTM) for treating prostate cancer. The device will be used

ansform phage display technology into a powerful tool for identification and validation of novel biologically relevant drugs. Moreover, we e
gms for drug discovery. As a result, we foresee that these toolsets will significantly improve the efficiency, economy and ease of performin
s. The ultimate goal of the proposed project is to develop and make commercially available new, powerful research bioinformatics tools: a d
iological disasters.

es as a simplified sample preparation method that is less expensive, more effective and suitable for resource-poor regions. Clinical and con
creases the likelihood of accomplishing the research objectives. Successful completion of Phase I goals will lead to scaling up the homogene

munoassay technology platform that can meet the needs of the point-of-care diagnostic market. The development of a handheld reader an

ial and antiviral arenas. Depending upon the outcome of this Phase I program, a Phase II is envisioned to encompass studies targeting the m
he current leads. The antitumor activity of two optimized leads chosen on the basis of the results of these studies will be determined by a c
porcine islet isolation parameters will be evaluated using the optimized perfusate for the definition of the potential clinical scope and tech

verse effects on many behavioral, reproductive, and physiological processes in humans. In this Phase II proposal, CertiChem (CCi) proposes
ept study will allow future Phase II project to study their toxicities and pharmacokinetics. Therefore, this project, if funded, has potential to
etinal vascular leakage in the oxygen-induced retinopathy (OIR) and streptozotocin (STZ)-induced diabetic models. K5 injection also effectiv
DME. These Phase II studies represent an essential step in developing a new drug. Retinal vascular leakage or breakdown of the blood-retin
he first medical provider in contact with a potential patient to make an immediate diagnosis of leptospirosis and initiate treatment. Lateral
of an integrated micro-scale gene expression profiling system for accurate genetics-based cancer diagnosis. In Phase I this system will be e

petency. The product will enable users, be they trainee or graduate physicians and other clinicians, to interact with game characters that pr

mune diseases which affect over 50 million Americans and are a leading cause of death and disability. Anticipated products are expected to

atient database will link clinical groups to guide diagnostic criteria and track symptom progression. It will maximize patient safety and comf
We will also assess the feasibility of the use of a microdialysis probe for on line sampling which will overcome the need of radio- or fuoresc
r loved ones, including improved quality of caregiver-care recipient interactions, caregiver health and mental health, and care recipient lon
 y et al. (1983; 1988) and questions previously employed by CME Development Group and its parent company MultiWeb Communications t

duced Neuroinfammation Cerbrovascular deposits of fibrillar amyloid are known as Cerebral Amyloid Angiopathy or CAA. CAA is found in g
we propose to directly measure whether COG112 will exacerbate or ameliorate colitis in mouse models.
velopment of new therapeutics will also provide for a potentially significant increase in quality of life for affected patients and their families

bilitating nature of this disease, and the startling healthcare costs, the current project to develop a novel therapy for MS has significant per
ct. Positive outcomes will lead to studies in humans to provide data to the FDA in support of a Pre-market Approval (PMA). . Currently avail
g both product formulation and delivery device, performing efficacy testing in an accepted animal model for seroma prevention, and perfo

urately process English in real life and to better monitor their own pronunciation using improved perception. The ultimate goal of this proje

minants out of the environment.

ortable and can be accommodated in a back pack. It will have the following novel features: 1) Light weight (estimated to be less than 3.6 k
review by several expert groups and software development. Following final beta testing and revision, the efficacy of the PSMP will be exam
edite evaluation of the fuctuation potentials. Long Term Objectives. The computational methods will be incorporated into a software pack

ard and soft tissues of the face, leading to major tissue deficits. Current mandibular distraction devices are used in combination with recons

rior system that is not currently available for use in public health research. The public health research and clinical communities would be
viduals in wheelchairs, who cannot or have difficulty transferring independently, and their caregivers. The Hoyer Lift, which has remained v

echanical modifications to the TRS4000 to improve efficacy in motor reeducation applications, and a clinical trial of sufficient sample size t

agents and cyanide poisoning. High concentrations of methemoglobin in blood lead to tissue hypoxia and even death. In the treatment of

e results obtained thus far provide a tantalizing glimpse of the method's potential. This proposal seeks to refine and extend prototype appa
and improve outcomes for young adults with autism spectrum disorders. The purpose of this Phase I Small Business Innovation Research (S
onfict resolution principles. These healthy relationships will serve to sustain recovery and prevent relapse.

ogram (FETP)-a Web-based innovative, comprehensive training resource for mental health professionals to help them engage and retain un
 practices around CF and we hypothesize that adolescents exposed to the intervention will demonstrate an increase in adherence to their t
tion. There is a general need to develop reliable and inexpensive products that can serve these needs." We believe this product, which is b
g teachers with instructions for implementing such an approach. In Phase II of the project period, formative research will be conducted, inc

time cost of care was $175,000. Alzheimer's disease costs corporate America $33.16 billion a year. The business community is often unawar
cation for services such as health care, education, housing, and humanitarian aid.

increasing knowledge, concern, and RBS skills among samples of fraternity and sorority social committee members and their advisors.
rogram in preparation for marketing the program.

f a pair of samples. In addition, the non-specific background will be further reduced in this step.

d for FA gene therapy, and will also provide the commercial basis for growth of DGI in the development of FA gene therapy using the SB tran

cluding the addition of communication capabilities, the development of an integrated 'smart' safety cap, and the development of an elegan
alth equity (such as the Gates Foundation or WHO), Phase III efforts will focus on the initiation of clinical trials in humans--with the ultimate

'test their tests' in a computer, without having to go through the lengthy lab testing process for each assay. The most difficult DNA-based t

orm at 11.7 T is projected to exceed that of state-of-the- art, room-temperature, short, double-tuned birdcages of 25 mm diameter by a fac
t least 1.0 GHz. The proposed work builds on earlier work in reducing rf sample heating and improving power handling and resolution in M

oduce digital x-ray CT images where each individual x-ray is counted and analyzed.

this innovative technology can also serve as indices for monitoring post-stroke patients. Therefore, this project may have substantial socioe

on diamond machining of the materials that are not conventionally considered to be diamond machinable. Diamond machining is an indis
he 11 kg commercial prototype of the EchoMRITM system for infants. After the commercial prototype of the EchoMRITM system for infants
hat are not (non-infected). In addition to verifying that this assay can differentiate infected from non- infected chronic wounds, this study w

ir effect on a P. gingivalis biofilm (Aim 1). The next objective is to demonstrate the ability of HG microbeads to prevent cell death of gingiva
tive SLPI from tobacco, production of the protein will be scaled up with a production cost objective of $1,000 per gram for preclinical studi
r third aim is to streamline the purification process for GroEL so that the costs of the protein which are currently very high, will not limit the
would be used to help them learn common words parts, independently remember meanings of new words, and expand their use of new w
hannels, and thus on many processes in the body, without actually having to give the drug to volunteers. In addition, the proposed technolo
ustrialized society and science-based education is critical to maintain our leadership in the world. With globalization and the inevitable con
ufacturing the SERS sensors and battery operated Raman readers. The components will be sold commercially through In Photonics, an affil
nalysis for small samples such as biopsies, identification of protein-protein interactions for research, drug development, etc., biomarker dis

MRI and histology, based on the success in Phase I. studies, we will also incorporate ex-vivo imaging and histology to validate our findings w

mum inhibitory concentrations and evaluate remaining candidates to choose lead compound(s) for Phase II research. The overall result of th

nd adaptation to different contexts. The proposed Web-based Training on Core Skills for Evidence-based Prevention Practice project provid
es (NOMs) for determining community and state effectiveness in dealing with alcohol and drug problems. This project proposes the develo
ate easily with family, friends and their community. Users enter icons along with text or symbols into an AAC device, and the VG tool transla
to cosmetically-superior lumpectomies at the time of the first surgery, (3) reduced emotional distress, (4) reduced complications due to re

characterization), etc.

ed brain disorder. The proposed exhibit, "Drugs and the Brain: a Serious Game" addresses the public health issue of drug abuse. It seeks to
will be characterized for expression of human Rh blood group antigens. 2. Induction of Rh-specific antibodies and placental antibody transfe

ts are necessary. After that, clinical data must be obtained, and regulatory approval must be sought. The market for the APD is huge, includ

dergone fibrinolytic treatment. It seeks to optimize prototype novel small molecule inhibitors of PK to obtain lead molecules that will be te

tion studies, in preparation of an Investigational New Drug (IND) filing. Brain tumors, a diverse class of diseases, are a major cause of morta
documented. The goal for Phase II is to identify lacritin constructs and perform preclinical trials to support IND submission. If successful, la
cal samples. The continued development and expansion of this technology holds great promise for new insights into cancer biology that ca
eral years. It is in such resource poor environments where CD4 counts are arguably the most important to perform. Current costs and assay

al describes a plan to produce an improved clotting protein (Factor VIII) that could be used to treat hemophiliacs since the current treatme
ned. The fundamental knowledge of the CIMS learned in the Phase I research will be used to design and fabricate an ESI-CIMS-MS system in
t the absence of oral fuid contamination during several different temperatures, normal or hyperventilating breathing patterns, and with/w
eat if, for instance, a patient fails to adhere to an antibiotic or antiviral medication. This can lead to the emergence of resistant organisms. W
ts for more efficient, targeted, and safe biodistribution of contrast agents. With intravenous injection, current Gd chelates distribute throug

auges the risk of bilirubin-mediated neurological damage in neonates and significantly improves the application of phototherapy for the tre
tentially offers a mechanistically based solution to not just faster wound closure but also significant cost savings and more importantly imp

in Phase I but on a much larger scale-collect speech data, build and test system, monitor system use with patients, and evaluate results. In

evention package will be conducted in Year 2. (Funding for a test of the SSP is being sought separately.) The online ESSP Model of Assessme

through severe knockdown of expression or gene activation through over-expression. There is no requirement of prior knowledge of the ge
determine the performance level of a set of 200 preproduction preamplifiers and reach a decision of whether to go forward with the comm
fines of two specific aims. The first will develop and validate a methodology to simultaneously assess the levels of the classical AR and the
essation of repeated treatment; and 3) reinforcement in an operant-conditioning paradigm, in laboratory animals are trained to press a lev
defects inspection and missile defense and their prototypes will be built up in Phase-II as a part of commercial applications.
an offer a truly green agricultural greenhouse operation via water recycle. energy storage/reuse, humidity control, and elimination of fungi
can offer a truly "green" agricultural greenhouse operation via water recycle. energy storage/reuse, humidity control, and elimination of f
rther anticipate that a polyurethane valve design can potentially mitigate the calcification and durability problems of bioprostheses associa

ed in two sets of field trials: an initial small scale formative (n=20) validation trial for each course that ensures everything is working correct
bining the protected SSA and general-release HRS data. If the demonstration is successful, the methods will be extended to the entire HRS

f we can identify novel cytoprotectants for photoreceptors and/or RPE cells as specified in Aims 1 to 3. Phase II of this multi-phase SBIR pro
standards. Phase II work will involve establishing a large photoreceptor toxicity database of chemicals-built both from existing knowledge a

computer infrastructure needed for data storage and extraction.

kage and extraction.
for use as MRI reagents, and demonstrate the use of glyconanoparticles as an efficient affinity label and in vivo cellular labeling and imagin

bility by constantly working with outside partners to ensure satisfying children's grasping needs remain central to the effort and in crisp foc

in a consistent and repeatable manner while eliminating the need for a skilled operator. The objectives for the Phase I feasibility study are:

lution of the AMP product in a clinical applications study in collaboration with the New York University sleep laboratory.

manage chronic conditions for themselves and their loved ones. The goal of this program is to promote health-related behavior on a daily

with the optimal in vitro and in vivo pre-clinical efficacy and potency for targeting breast cancer. These Mabs will require further developm

expensive than currently available MDIs. In the US, 10% of the population has asthma, 5000 people die from it each year, and the total co
upercritical carbon dioxide in an economical process. Malaria continues to be a worldwide public health problem, sickening over 100 m

. This innovative and versatile toolkit will accelerate creating chronic sleep restriction animal models and help break the notable barrier of
such as sleep and wake activity, thus shedding light on the interdependence of cognition and other neurobehaviors. Our novel approach is
loped for myoblast engraftment can be retooled for engraftment of other cell types into other tissues, leading to greatly improved cell eng
Infection surrounding metal hardware is a common and sometimes devastating cause of implant failure in a number of medical fields inc
s on TCP matix, while retaining BMP-2's activity and the osteolbasts' phenotype. Finally, a rat mandible defect model will be used to investig
quick as possible (ideally, less than 1 hour).
enefits: 1.Enhance the ability to monitor the health and well being of the elderly. 2.Enable further long and short term research in the elde
 will be the primary outcome. The well-supported rationale for heparan sulfate and Perlecan D1 delivery to support tissue regeneration, co
ed from common bone graft materials or by copolymerization with resorbable poly D-lactide microparticles through an industry partnersh
ty schools, and tapping into outreach programs such as the University of Colorado Science Discovery program with access to 30,000 studen
and cumbersome connection procedures the wireless technology being proposed here is self organizing and self maintaining. Therefore bo

luding opioid-induced bowel dysfunction (e.g., severe constipation, nausea and vomiting) and post-operative ileus. AIKO Biotechnology wil

e tissue expanders will also be easily re-shapable by the surgeon to custom fit certain tissues using tools readily available such as scissors. P
rated, injection-molded test cartridge; test and evaluate reagent stability and longevity within the test cartridge; encode the array decision
konni's technology and product solutions provide a straightforward path for diagnostic detection of trace RNA viruses and infectious diseas
he living tissue be it neurons, heart tissue or kidney, etc. long term stability, and sterility are a must. Small peristaltic pumps have been sho
ader Project Narrative: The multi-well or microwell plate has become ubiquitous in research and clinical laboratories for processing multipl

search, we will undertake efforts to successfully develop and market these screens through our own resources and in collaboration with ou
e molecule's purpose.

like a database. But researchers would be better served with a more "search" like approach to extracting and correlating facts in text and d

tes as targets of relapse prevention. Therefore, in this aim, we examine the effect of transdermal delivery of CBD on withdrawal severity inc

nterest or concern such as breast masses in a medical image. It also measures numeric features of the mass, analyzes the important inform
usters of disseminated tumor cells that characterize metastatic disease. Preliminary results from our laboratory have demonstrated that pe

es behave. The research proposed here seeks to expand the toolbox applied in analysis of cellular carbohydrates and establish processes to

ently, DNA sequencing of the mutant virus cannot easily detect subpopulations of drug-resistant strains below 20% which can lead to failure
MASSIVE-PRO will be validated by full-sequencing on DNA extracted from surgically removed matched tumor tissue. For the purpose of dev
e number of PCR and cell-free translation reactions will also be evaluated. These assays, once optimized, will be extensively evaluated in co
ostics by developing an integrated technology that will augment current pathology practices and result in more accurate cancer diagnoses.
gnostic Assay. The availability of this assay for leukemia and MPD mutations should greatly improve the clinical decisions necessary for effe

y difficult to solubilize in the micellar conditions typically used for membrane proteins. To allay this limitation, we propose to synthesize an
 s in vitro cellular and kinase targets and in an in vivo tumor model, will be focused on identifying an optimized lead for entry into preclinica
tion is to evaluate a lead small-molecule drug candidate in clinically relevant models of Scleroderma to develop sufficient data to continue
ity in different cell lines, to determine the effective dose and to better understand the mechanism of action of Ang797 and its analogs in vi
ss to Interventional Development program are underway and preliminary results are extremely encouraging. This translational research Ph

trains will be further developed for eventual clinical application. Deletion mutants will be developed to reduce the probability of reversion

feration and/or infammation with either PG monotherapy or PG/1,25(OH2)D3 combination therapy relative to vehicle alone in the mouse

MP synthesis and IND-directed toxicology studies with ABC294640. Overall, the studies proposed represent a focused approach to evaluate
e prevention of graft rejection. We hypothesize that islets decorated with FasL will induce tolerance by eliminating xenoreactive lymphocyt
o weeks) manner without compromising the function of the protein or the cell. Third, chimeric proteins can be conjugated to biotinylated m
mune's novel immune system-based therapy, ApoVax104 vaccine, is a new, innovative approach to treating cancer and malignant neoplastic

ormance of the Crystal Finder(tm) microscopic workstation provides the basis of its commercial success. It is expected to set the standards

both novices and experts alike.

g the display will bring intelligence into the display, providing complex optimizations with a simple presentation to the user. 7. PROJECT NA

lic health vector control specialists are very supportive of the proposed work plan and technology.
oarray for ecotoxicology testing in salt water. This microarray, together with the database this project will begin, can provide detailed, gene-
cause it is predicted to improve the overall quality of life of advanced lung cancer patients by providing immediate palliative relief from the

e container with unique and permanent identification will be reduced (Specific Aim 1), commercial versions of the semi- and fully-automati
hers in these areas. An efficient drug research and development process requires the in-depth understanding of the molecular, cellular and
ng infections of CF patients. At present, 80-95% of CF patients ultimately succumb to respiratory failure due to chronic P. aeruginosa infecti
-brain barrier (BBB). The present work will produce a novel recombinant fusion protein that is able to both (a) bind a human BBB receptor t

iosensor technologies.

h translation of this cell based therapy from the laboratory to the clinic.
adjustment. The novel long acting formulation of buprenorphine will be able to maintain analgesia in rodents for at least 3 days following
 ased output. These can be accomplished by modification of the enclosure and replacing the transducer with a more efficient device. /Relev
Non Ribosomal Peptide Synthetase (NRPS) complex. The approach effectively circumvents the most daunting problem associated with prep

developed similar products before, we are confident that the successful completion of this work will culminate in a commercial product of

ochemical, histological and semi-quantitative histopathological analyses. The new forms of TGF-a peptantagonist developed in these studie

with a promising F lead compound, F-AV-133, for imaging VMAT-2 expressed on beta cells.
the distal nerve segment of the recipient. Every year in the US, several million people suffer serious peripheral nerve injury. Injuries to the
r neurological disorders such as stroke and diabetic neuropathy, which represent much larger markets. for STTR Resubmission for "Calpain

y, and patients that are likely to have poor progression and outcome will be evaluated. This analysis will determine the sensitivity and speci
in accurately assessing the functional impact of pain.
exploit Barron Associates' recently-patented [73] six degrees-of-freedom wireless motion monitoring capability and sophisticated signal pro

mers seeking to recover from their addictions and their families; and 3) economic savings. In addition, the innovative use of a web-based ap
e two national public mental health needs through the development and commercialization of the Hispanic Stress Inventory - Adolescent. T

fferent 16-week PRT groups stratified by gender: (GROUP 1) 9 males and 9 females will perform traditional SC-LC training with the weight-s
s is their acceptance of solid dosing forms, such as capsules or tablets. Pigs swallow pills willingly, without coercion or handling, if the pills a

of breast tumors that are not visible using x-ray mammography or ultrasound. By using real-time probe positioning, procedure time will be
ntation in varied bioscience laboratories. The key LabmatrixTM innovation is the capture of scientific practices common across labs into one
hosphorolysis-activated polymerization (PAP) for this technology developed by the City of Hope hospital. Not all DNA polymerases efficient
mplification (MDA). Rubicon Genomics commercializes GenomePlex(tm) Kits for Research Use through Sigma-Aldrich. GE Healthcare marke
advance of a clinical testing protocol. The proposed research is expected to produce technology for significant benefits to public health. T
pment of new or more effective anti-mycobacterial drug therapies. This project will directly benefit public health by providing a techno
development person is now required to develop these channels to support the commercialization of this device into these markets. A hand
ution, cytotoxicity, and evaluation of the physiological response to the optimal combination dose of the resuscitation fuid in a pig military-r
y-relevant animal model (pig), study tissue distribution, pharmacokinetics, reabsorption and toxicity of HAF. Upon completion of the phase
ntal epidemiologists and risk assessors to quantify, model, and investigate spatial and temporal relationships between exposure and diseas
and broaden its utility for the production of a variety of diverse peptide antigens. We will also develop molecular biology techniques to inc
ms affected, current serodiagnostics for Lyme disease lack sensitivity in early disease and are not specific enough to be used alone. Our obje

d soluble TL1A in certain infammatory diseases will provide us with the rationale for the development of TL1A as a biomarker of the disea

orse) used in biomedical and veterinary research. In this Phase I Small Business Innovative Research application, Bioptigen Inc. proposes to
e-scarce regions most impacted by HIV disease, helping to narrow the health care quality gap between the developed and developing world

ty . In combination with fuorescent molecules they provide for high quality replacements for older radioactivity based methods. Technolog

sing of recordings and creation of personalized acoustic inventories. Speech communication ability is impaired or absent in millions of Ame
nd highly reproducible bacterial fingerprinting tool, LH-PCR, in the study of microfora in the GI tract. The team assembled for this proposal

robial identification using predictive software, novel molecular techniques, and mass spectral analysis of ribosomal RNA fragments.
minate the devastating effects of diabetes to human health (especially juvenile Type I diabetes), like blindness, kidney failure, and increased

of-of-concept software into a user-friendly commercial software module which we will offer to existing and potential automated patch clam
endence for persons with visual acuity between approximately 20/200 and 20/600, aiding them in everyday tasks such as travel, navigation

e a long acting VEGF inhibitor that can be dosed once a week or once every two weeks.

ns are reported annually in the USA, 90,000 of which result in death. Reducing the spread of infectious diseases within healthcare facilities

ns. This characterization will be achieved using X-ray fuorescence measurements of proteins, their post-translational modifications, and any

, tau, amyloid Aa, and prion proteins). In Phase II compounds with the highest efficacy, potency, spectrum and selectivity will be optimized
n neurodegenerative disease, affecting over 1 million patients in North America alone. Current clinically approved medicines for Parkinson's
small animal model. The proposal titled "Long Circulating Targeted Nanoparticles for Non-Hodgkin's Lymphoma Treatment" outlines the de

vide a rescue of behavioral deficits, which will be correlated with improvements in AD-like pathology. The goal of this proposal is to establis
n to be an effective treatment but there is only a very limited source of cells. The progenitor cell expansion technology prospectively fulfills

e cancer. The device will be used to apply freezing temperatures (cryoablation) to destroy unwanted tissue.

relevant drugs. Moreover, we envisage a major impact on the molecular dissection of human disease mechanisms. For example, these rea
economy and ease of performing HT RNAi screens, and will provide basic researchers with preferred, cost-effective alternatives to existing
research bioinformatics tools: a database of functionally validated, genome-wide human and mouse shRNAs and algorithms for prediction

e-poor regions. Clinical and contrived samples (standards) will be used to establish sensitivity and consistency of the reagent in detecting t
lead to scaling up the homogeneous population of ventricular-CMs and commercialization of products by developing high throughput assa

opment of a handheld reader and associated SERS nanotags open up the capability of significant multiplexing of diagnostic tests in the doc

ncompass studies targeting the mechanism of action and the in vivo efficacy of Phase I lead compounds, library expansion and lead optimi
studies will be determined by a contract research organization in xenograft mouse models of relevant human tumors. The research will aim
potential clinical scope and technology limits. Finally, human pancreases that are unsuitable for transplantation will be employed for pre-cl

posal, CertiChem (CCi) proposes to develop a very sensitive and accurate assay to measure anti-estrogenic activity in a set of reference test
roject, if funded, has potential to generate marketable products for the treatment of a major blinding disease. As retinal NV affects a large
models. K5 injection also effectively ameliorates the retinal NV in the OIR model. K5 down-regulates the VEGF expression in cultured retina
or breakdown of the blood-retina barrier is an early feature of diabetic retinopathy and can leads to diabetic macular edema, which is the
is and initiate treatment. Lateral fow tests are highly suitable for use in developing countries, as well as in a variety of field or community s
s. In Phase I this system will be evaluated in terms of sensitivity and robustness using gene expression profiling based on several characteris

act with game characters that provide the opportunity to enhance empathic understanding of the lived experience of illness from malignan

cipated products are expected to improve treatment, reduce morbidity and improve the quality of life of patients suffering from these dise

aximize patient safety and comfort through a small, non-invasive, unobtrusive, untethered design that can be used in the clinic or home. It
me the need of radio- or fuorescent labeled compounds for permeability studies. 4) To implement a new design of the trans-endothelial ele
tal health, and care recipient long-term care placement and health status. The website DementiaCareCentral.com is designed to provide ed
any MultiWeb Communications to evaluate educational programs, an evaluation section for each module will be developed and tested; 4) M

opathy or CAA. CAA is found in greater than 97% of all autopsy confirmed cased of Alzheimer's disease (AD). CAA is also associated with rob

ected patients and their families.

herapy for MS has significant personal, social, and economic benefit to MS patients and their families.
Approval (PMA). . Currently available bone adhesives and cements may bond bone surfaces together, but do not resorb over time and trans
or seroma prevention, and performing feasibility studies in humans to provide data to the FDA in support of a Pre-market Approval (PMA).

n. The ultimate goal of this project is to develop a multimedia system for the assessment and training of speech perception by learners of E

(estimated to be less than 3.6 kg which includes a miniature Alcatel turbo pump, a diaphragm pump and an electronics box), 2) will operat
efficacy of the PSMP will be examined in a longitudinal study. Approximately 80 million people in the United States suffer from chronic pain
ncorporated into a software package offering a suite of electrostatics models with diverse computational performance and modeling fidelity

used in combination with reconstruction plates, but while the reconstruction plates take the contour of the jaw, the distraction devices hav

d clinical communities would be the likely markets interested in the CAT technology that would be developed and evaluated in this STTR.
Hoyer Lift, which has remained virtually unchanged since its 1958 patent and Hoyer-style lifts are commonly used to perform basic transfer

al trial of sufficient sample size to demonstrate efficacy of the FES-enabled TRS4000 for exercise with the potential for motor re-education

even death. In the treatment of methemoglobinemia, it is critical to be able to measure the methemoglobin concentration accurately. A no

efine and extend prototype apparatus and methods developed during Phase I to allow academic and non-academic structural biologists em
Business Innovation Research (SBIR) proposal is to develop Supporting Transition In Vocation and Education (STRIVE) postsecondary transiti

help them engage and retain underserved children and their families in treatment.
n increase in adherence to their treatment regimens. A recent National Institutes for Health solicitation for research to improve self-manage
e believe this product, which is based on a great deal of NIMH funded research, promotes that mission. A diagnosis of BPD in one person im
e research will be conducted, including a needs assessment with students, teachers, and experts to finalize content areas and product desi

ness community is often unaware of its annual expenditures impacted by Alzheimer's disease, primarily because of the popular belief that

members and their advisors.

FA gene therapy using the SB transposon system. This project describes the development of a non-viral gene transfer method for treatment

nd the development of an elegant data management system, will enhance user- and management-acceptance.
als in humans--with the ultimate goal of eliminating the human health burden of filarial diseases. (Relevance to public health) Parasitic nem

y. The most difficult DNA-based tests are also the most important. There are very small differences between the genetic code of deadly pat

ages of 25 mm diameter by a factor of 3; and the C S/N will 13 exceed state-of-the-art RT double-tuned birdcages by a factor of 4, which ca
wer handling and resolution in MAS probes; and it adds proprietary, novel technologies to achieve record- shattering power handling. Initia

oject may have substantial socioeconomic impact.

. Diamond machining is an indispensable machining process for fabricating ultraprecision macro- and micro- optics and non-optical compo
e EchoMRITM system for infants (1-11kg) is validated by measuring small piglets during the second year of Phase I, a future Phase II study
ted chronic wounds, this study will define a cutoff activity level that distinguishes the two. The last goal of our proposal is to correlate targe

s to prevent cell death of gingival fibroblasts after P. gingivalis infection (Aim 2). Lastly, a mouse chamber model will be used to assess the a
00 per gram for preclinical studies of the anti-HIV properties of the protein during Phase II. Achievement of the goals of this STTR project is
rently very high, will not limit the usefulness of the system to the research community.
s, and expand their use of new words, and apply their skills to hundreds of new high-frequency, high-utility words. The instructional progra
 addition, the proposed technology could make possible accurate measurements of specific ion channel currents and might enable develop
balization and the inevitable continued export of lower skilled manufacturing jobs, future careers for our citizens will require improved ma
ally through In Photonics, an affiliated company under common ownership.
evelopment, etc., biomarker discovery. These applications already guide the substantial proteomic microarray market; the proposed techn

tology to validate our findings with MRI and the post-processing software.

research. The overall result of this research will be one to three high-quality lead compounds to be further developed as antibiotic drugs. T

evention Practice project provides an innovative approach to transferring evidence to practice by focusing on individual competencies and
This project proposes the development of a web-based prototype that makes use of archival data sets on ADO incident data to facilitate loc
C device, and the VG tool translates each icon into synthesizer parameter strings that control the acoustic characteristics of the synthesized
reduced complications due to reduced number of surgeries and shorter recovery times for the patient and (5) reduced cost for the patient

h issue of drug abuse. It seeks to educate the public about the impact of drugs of abuse on the brain and mental functioning. It is hoped th
es and placental antibody transfer in RH transgenic mice. Rh-specific antibodies will be induced in the transgenic mice as proof of our hypot

arket for the APD is huge, including hospitals, clinics, physician's offices, ambulances, and home care facilities. Because of its size and cost

in lead molecules that will be tested in animal models of thrombosis in Phase I, then proceed into preclinical development in Phase II for a

ases, are a major cause of mortality particularly in children and young adults with an estimated 13,000 deaths from primary brain tumors p
t IND submission. If successful, lacritin would be the first agent to combat dry eye by increasing tear production, reducing infammation and
sights into cancer biology that can impact human health through better detection of disease and ultimately enhanced treatment options
perform. Current costs and assay complexities limit this. An accurate CD4 count can be employed: to facilitate AIDS surveillance; to monitor

hiliacs since the current treatment is often rejected by the body. The proposed reengineered protein will be evaluated in a mice that have a
bricate an ESI-CIMS-MS system in Phase II, which will be commercialized to support a wide range of biomedical research. Proposed chiral
g breathing patterns, and with/without active breath management. (Milestone: Completion of performance data by 12/31/2007). The shor
ergence of resistant organisms. We propose to develop a small portable device that a patient can blow into shortly after taking their medica
ent Gd chelates distribute throughout the body and are quickly excreted through the kidneys. These agents do not target specific sites; rath

ation of phototherapy for the treatment of hyperbilirubinemia. Current diagnostic tests for elevated plasma concentrations of bilirubin do n
vings and more importantly improving the quality of life in diabetic patients. The development of FSR's ACT1 peptide via milestones outline

patients, and evaluate results. In this phase, Sehda will also be comparing the system's performance with the performance of human interp

e online ESSP Model of Assessment and Prevention (MAP) includes the assessment tool; a problem-solving process; staff development wor

ent of prior knowledge of the gene's identity or function for RHGP to target. RHGP is a reversible gene perturbation method that offers ins
her to go forward with the commercialization process or to revisit the device design stage to address any remaining performance problem
evels of the classical AR and the mAR from both brain tissue and blood (white blood cells). The latter will address whether simple blood me
animals are trained to press a lever to self-infuse the drug. The most potent compound (based on the in vitro and in vivo data) will be chose
control, and elimination of fungicide use.
dity control, and elimination of fungicide use.
oblems of bioprostheses associated with tissue fixation and leafet mounting. Finally, a polyurethane valve can be manufactured at a subst

res everything is working correctly in each course and a set of larger summative trials (n=440, home health care personnel; n=120 nursing s
 ll be extended to the entire HRS/SSA linked data in a future project.

ase II of this multi-phase SBIR project will initiate more extensive in vivo studies to confirm the efficacy of the compounds identified in Phas
t both from existing knowledge and results from our assay system-to improve the predictive accuracy of compound safety. Phase III of the p

vivo cellular labeling and imaging, and develop a full operational protocol for end-users. A simple and versatile methodology is proposed f

ntral to the effort and in crisp focus. If successful, the Phase II effort will produce a child's prehensor that is functionally superior to all curre

the Phase I feasibility study are: Aim 1. Design and fabrication of sonic tissue dissociation system for the recovery of islets of Langerhans. A

ep laboratory.

ealth-related behavior on a daily bases.

bs will require further development activities as potential therapeutic candidates in order to be considered for clinical trials in breast cance

om it each year, and the total cost to the economy is over $18 billion per year; notably the impact of asthma is especially hard on African A
th problem, sickening over 100 million people per year and killing over 1 million of them. Unfortunately, malaria usually strikes populations

elp break the notable barrier of EEG expertise required in sleep research. The DiscTreadmill with alternative noninvasive sleep detection/re
ehaviors. Our novel approach is fexible, scalable, and provides a foundation for a high-throughput cognitive assay system to be developed
ding to greatly improved cell engraftment strategies that will support regenerative cell therapy across numerous human diseases.
n a number of medical fields including oral, craniomaxillofacial (CMF), orthopedic, and cardiovascular surgery. Arising from the establishme
ect model will be used to investigate the ability of peptide coatings to increase bone formation at lower doses of recombinant BMP-2. Grow

d short term research in the elderly (and other) population 3.Enable the long-term monitoring and early intervention in high-risk populatio
o support tissue regeneration, coupled with these preliminary data and Agenta's relevant patent, uniquely positions Agenta to fulfill the ob
s through an industry partnership. Periodontal regeneration in vivo will be assessed by radiographic and volumetric magnetic resonance im
am with access to 30,000 students; 4) disseminate broadly by working with publishers to align simulation content with existing and propos
d self maintaining. Therefore both setup and maintenance costs for such an infrastructure is low and usability is high. At the end of the pro

ve ileus. AIKO Biotechnology will determine the feasibility of using its proprietary peripherally restricted opioid neutral antagonist for treat

adily available such as scissors. Phase II development will focus on creating a marketable prototype and animal studies. The objective of th
ridge; encode the array decision logic into user-friendly software; test and evaluate the integrated prototype on neat and amended nasal s
NA viruses and infectious diseases in an integrated, sample-to-answer test cartridge and field portable instrument.
peristaltic pumps have been shown to do a very good job at exchanging media in small chambers, and two pumps can do a very good job o
boratories for processing multiple samples with high speed and reproducibility. Radiation Monitoring devices proposes to develop a detect

rces and in collaboration with our commercial partners. Applications of a scintillator with very bright emission, high spatial resolution, high

nd correlating facts in text and databases. We are committed to making all the facts, or total recall, available to scientists which is currently

f CBD on withdrawal severity including seizures, withdrawal- induced anxiety on the Elevated Plus Maze and perseverative behavior on the

s, analyzes the important information content and then compares the mass of interest to images of masses with known findings and outco
atory have demonstrated that peptide targeted a-emitters are very effective in treating melanoma in pre-clinical therapy studies. Refineme

drates and establish processes to further biochemical understanding of their more subtle purposes. The results of this research will be prac

ow 20% which can lead to failure of treatment. Recent progress by AmberGen demonstrates that this limitation can be overcome by using
or tissue. For the purpose of developing a CRC population screen which meets the requirements of a clinical laboratory environment and f
ill be extensively evaluated in collaboration with Dr. Ludwine Messiaen, Director of Genomics at the University of Alabama and a world lead
more accurate cancer diagnoses. We will apply this technology to prostate cancer to give physicians additional molecular information that m
nical decisions necessary for effective treatment of leukemia and MPD patients while improving clinical laboratory workfow and reducing c

on, we propose to synthesize and characterize several novel cholesterol derivatives.

 ized lead for entry into preclinical development in a future SBIR Phase 2 application.
elop sufficient data to continue SBIR Phase II studies.
n of Ang797 and its analogs in vitro. The proposed in vivo studies will provide important preclinical efficacy data regarding the ability of thi
g. This translational research Phase II application is designed to explore fully the therapeutic potential of Refanalin in SCI. Dose-response, t

duce the probability of reversion of auxotrophs to wild-type. Determination of possible synergy of tumor targeting S. typhimurium auxotrop

e to vehicle alone in the mouse models. If successful, a follow-on Phase II proposal will be submitted to conduct definitive animal studies o

t a focused approach to evaluate and move the SK inhibitor ABC294640 into clinical trials for the treatment of ocular disease. This will prov
minating xenoreactive lymphocytes via apoptosis and expanding T regulatory cells. Rapamycin is expected to further augment this response
n be conjugated to biotinylated molecules of interest via streptavidin/biotin interaction and used as vehicles to deliver such molecules to ce
cancer and malignant neoplastic diseases.

is expected to set the standards for automated high-throughput image-enhanced protein crystallization experiment screening and will be

ation to the user. 7. PROJECT NARRATIVE Applied Medical Visualizations L.L.C. has developed a graphical drug display intended for anesthes

egin, can provide detailed, gene-level data on the biological impact of a chemical or an environment. In so doing, it can lead to assessment
mediate palliative relief from the symptoms of obstructed airways such as coughing, choking, inability to eat, etc. It is predicted to provide

s of the semi- and fully-automatic Precision Dispensing System will be designed and built (Specific Aim 2), and the workfow-based liquid s
ng of the molecular, cellular and toxicological properties and mechanisms of a drug candidate. Collecting this information is a daunting tas
e to chronic P. aeruginosa infection and airway infammation.
(a) bind a human BBB receptor to trigger transport into the brain, and (b) retain high lysosomal enzyme activity. This novel drug, designate

ents for at least 3 days following a single subcutaneous injection. Such a formulation will improve the well-being of animals by reducing the
 th a more efficient device. /Relevance Millions of hearing tests are conducted each year in the US with methods that are essentially unchan
ng problem associated with preparing cyclic peptides by synthetic chemistry: efficient, regiospecific cyclization of the linear precursor. Using

inate in a commercial product of significant medical utility.

gonist developed in these studies should be ideal drug candidates for treating pulmonary fibrosis in humans. The goal of this project is to d

eral nerve injury. Injuries to the peripheral nervous system (PNS) are a major source of disability, impairing the ability to move muscles or t
STTR Resubmission for "Calpain Inhibitors for Cancer Related Neuropathies": This work is directly relevant to public health, as our research

termine the sensitivity and specificity of markers BA0123 and BA0252 when used singularly or in combination. These data will be used to s

bility and sophisticated signal processing to identify the key qualitative and quantitative attributes of GMs, and thereby automate the asses

nnovative use of a web-based application like OA has the potential to reach a significant segment of the population that might not otherwis
c Stress Inventory - Adolescent. This new clinical screening tool will significantly increase the capacity of mental health professionals to pre

SC-LC training with the weight-stack and (GROUP 2) 9 males and 9 females will perform motor-driven VSC-VLC training. The hypothesis to
oercion or handling, if the pills are hidden in a cookie. This device will collect programmed blood samples to establish the pharmacokinetic

itioning, procedure time will be significantly reduced as compared to the current procedures that iterate with procedure planning, probe p
ces common across labs into one integrated software package that enables broad sharing and re-use of data, a step in laboratory practices
ot all DNA polymerases efficiently perform PAP. For, example a modified Taq polymerase bearing a F667Y mutation that greatly enhances th
ma-Aldrich. GE Healthcare markets MDA technology under the name GenomiPhi(tm) while Qiagen sells MDA kits under the name REPLI-g(r
ficant benefits to public health. The research is particularly relevant to improved capabilities for the monitoring of cardiovascular disease st
blic health by providing a technology for efficient simultaneous testing of hundreds to thousands of cellular phenotypes. It will be applied in
evice into these markets. A handheld inexpensive pneumothorax detector will be commercially attractive to emergency medical personnel
uscitation fuid in a pig military-relevant model. More than 200,000 people in the U.S. die from septic shock and hemorrhagic shock each y
F. Upon completion of the phase II effort, phase III studies will involve extended pharmacokinetic studies for filing an Investigative New Dru
ps between exposure and disease in unprecedented detail.
 ecular biology techniques to incorporate modified amino acids (such as phosphoamino acids) into the peptide antigens expressed in bacte
nough to be used alone. Our objective is to replace today's assays with a new multi-peptide test. Because of greater specificity and the imp

TL1A as a biomarker of the diseases in the future phase study. A family of proteins in the body can cause infammatory reactions that a

ation, Bioptigen Inc. proposes to prototype a portable, handheld cornea and anterior segment optical coherence tomography (CAS-OCT) sc
developed and developing world.

tivity based methods. Technology to be developed under the proposed research at Biosearch Technologies should find broad applications

ired or absent in millions of Americans due to neurological disorders and diseases and to trauma, including autism, Parkinson's disease, and
am assembled for this proposal is interdisciplinary and combines three very valuable sets of expertise to address the complexity of the GI m

bosomal RNA fragments.

ess, kidney failure, and increased mortality. If successful, the BioTex glucose- sensing technology will in conjunction with an insulin pump im

potential automated patch clamp companies. We will also simplify and streamline the user interface of this software as a stand-alone com
y tasks such as travel, navigation, and social interactions. It will advance today's state of the art in assistive devices for low vision by improv

eases within healthcare facilities, and in the general community would ultimately translate to saving lives, increasing productivity, and impr

nslational modifications, and any binding partners (drugs, proteins, co-factors). These measurements use native, unmodified proteins and r

and selectivity will be optimized and tested in animal ALS models. Amyotrophic lateral sclerosis, also called ALS and Lou Gehrig's disease, a
proved medicines for Parkinson's disease help alleviate disease symptoms, but do not slow the progression of the underlying disease. We p
homa Treatment" outlines the development of a tumor-targeting, biodegradable nanoparticle formulation of doxorubicin designed for use

oal of this proposal is to establish a strong, well-integrated research program based on recently established roles of Th1/Th2 immunity, HU
technology prospectively fulfills unmet clinical needs by supplying a source of a cells. Multiple transplants may be performed from single p

hanisms. For example, these reagents harbor considerable promise to identify new targets for therapeutic intervention, and the developm
effective alternatives to existing commercially available reagents. The ultimate goal of the proposed project is to develop and make comme
As and algorithms for prediction of functional shRNAs. We propose to apply these tools to develop genome-wide functionally validated siRN

ncy of the reagent in detecting the viral load.

developing high throughput assays in Phase II. Using renewable hESCs lines to generate a homogeneous population of ventricular-CMs will

ing of diagnostic tests in the doctor's office, thus saving costs, speeding diagnosis, and leading to prompt treatment without the long wait

brary expansion and lead optimization as well as the inclusion of screens targeting specific parasites. The research involves the synthesis of
an tumors. The research will aim to discover a new type of drug for cancer treatment that is based on chemical variations of the sugar com
ation will be employed for pre-clinical validation of this technology. It is anticipated that the availability of a pancreas transporter and panc

activity in a set of reference test chemicals and in common consumer products. CCi proposes to use these data and CCi's data on estrogen
ase. As retinal NV affects a large population, and as there is no effective drug available on the market, these new anti-angiogenic drugs shou
EGF expression in cultured retinal M ller cells, the major producer of VEGF in the retina and in the retina of OIR rats. K5 also inhibits endoth
tic macular edema, which is the single greatest cause of vision loss in diabetic patients. Currently, there is no effective drug treatment for d
a variety of field or community settings, because they require no equipment to use, are room temperature stable, and have long shelf lives
ling based on several characteristic cancer genes by detecting small quantities of reconstituted cDNA or RNA from tumor cells. Clinical eval

perience of illness from malignancy, as felt by patients in minority populations. When completed, the research will create a low-cost, easily-

atients suffering from these diseases.

be used in the clinic or home. It will illustrate through large, well-designed, multi-center clinical trials that the MPPS accurately captures PD
esign of the trans-endothelial electrical resistance measurement system in order to allow for the measurement of the impedance of BBB by
al.com is designed to provide education and tips about dementia and caregiving. More specifically, it will help informal (unpaid) dementia
will be developed and tested; 4) Market the completed 6-module educational program. CME Development Group and MultiWeb Communic

). CAA is also associated with robust activation of neuroinfammatory cells and the release of infammatory cytokines like Interleukin-6 (IL-6

o not resorb over time and transition the wound to natural healed bone. This leads to a high rate of non-unions when cement eventually s
f a Pre-market Approval (PMA). . Seroma formation is among the most common post-surgical complications, occurring in up to 50% of cert

eech perception by learners of English as a second/foreign language. The final product will improve English communication between perso

an electronics box), 2) will operate with power provided by a 24 volts power pack consisting of miniature Li batteries put together in the for
d States suffer from chronic pain. Due to the high costs of health care, increased demand for services, and dwindling access to multidiscipli
erformance and modeling fidelity options. The software will be distributed through an established molecular modeling vendor. Interfaces w

e jaw, the distraction devices have a linear vector. A robust prototype intra-oral mandibular distraction device was shown to be mechanical

ped and evaluated in this STTR.

ly used to perform basic transfers, but they are not able to transfer people in and out of the tub, or lift a person from the foor. Both of the

otential for motor re-education improvements. The target market for the device will be rehabilitation clinics that provide care to individual

in concentration accurately. A noninvasive and reliable methemoglobin sensor will have great impact on therapeutic decision time.

academic structural biologists employing NMR spectroscopy to use the approach and thereby gain access to proteins that are not amenable
n (STRIVE) postsecondary transitional support training materials for use in special education or advocacy settings for individuals with Asper
 research to improve self-management and quality of life in children and adolescents with chronic diseases stated that, "Children with a chr
diagnosis of BPD in one person impacts the entire family. Disruption of family, work, and personal life, and the burden of worrying about th
content areas and product design. The product development period will be used to complete the Teacher's Guide, video program, and acc

cause of the popular belief that the disease affects only individuals who have retired from the workforce. That misconception overlooks th

e transfer method for treatment of Fanconi anemia, a rare disorder of the blood, by Discovery Genomics, Inc. (DGI), a small biotech startup

ce to public health) Parasitic nematodes (roundworms) currently infect over 1 billion people globally, causing severe morbidity and conside

n the genetic code of deadly pathogens and harmless microorganisms. ThermoBLAST will greatly improve the ability of scientists to design

dcages by a factor of 4, which can lead to a factor of 16 reduction in signal acquisition time for constant resolution. For the more common fi
shattering power handling. Initial field testing at an outside institution at 900 MHz is expected by the end of the first year in Phase II. Th

o- optics and non-optical components for biomedical products, including such as diagnostic imaging devices, drug delivery components, im
Phase I, a future Phase II study (not part of this proposal) will then require that the equipment be tested on human infants. The EchoMRIT
our proposal is to correlate target peptide cleavage in vitro with known quantities of purified bacterial proteases. This information will be n

odel will be used to assess the ability of HG delivered on beads to reduce P. gingivalis virulence, viability, and the host infammatory respon
f the goals of this STTR project is expected to provide the basis for low-cost commercial production of megagram quantities of a potentially

y words. The instructional programs that will result from this project will be usable as literacy intervention programs based on individual ne
 rrents and might enable development of new drugs to target the activities in those channels. Finally, the technological improvements prop
itizens will require improved mastery of science and technology. Shortages of scientists and engineers will result in continued high technol

rray market; the proposed technology is expected to offer significant improvements in time, cost and sensitivity to existing approaches.

developed as antibiotic drugs. These metagenome-derived lead compounds may be very different from known antibiotics; their commerc

on individual competencies and skills necessary to effectively implement practices found to be widely applicable through scientific studies.
ADO incident data to facilitate local (county) level planning and assessment efforts. This project can bring important benefits by effectively p
characteristics of the synthesized speech.
(5) reduced cost for the patient and the healthcare system. Successful completion of this project will set the foundation for the developme

mental functioning. It is hoped this will both teach the public about the science of drug abuse researchand the importance of its continued
genic mice as proof of our hypothesis and the validity of this system as a model of HDN. The final validation of the system will be demonstr

ties. Because of its size and cost and ease of operation, the APD is an ideal device for home use and for pharmaceutical testing of new drug

al development in Phase II for adjunctive therapy for MI patients receiving fibrinolytic therapy.

ths from primary brain tumors per year. Unfortunately few treatment options currently exist for patients with this disease which is made ev
ction, reducing infammation and restoring damaged lacrimal tissue. Dry eye is a ubiquitous, under diagnosed and poorly understood ocula
enhanced treatment options
ate AIDS surveillance; to monitor the rate of progression to AIDS, to define when therapy is required to prevent opportunistic infections, to

e evaluated in a mice that have a hemophilia as well as in mice that have a human- like immune system.
dical research. Proposed chiral ion mobility spectrometer - mass spectrometer, separating and identifying chiral compounds in seconds, c
e data by 12/31/2007). The short term objective of Xhale Diagnostics, Inc. is to develop these devices to a market of $70 million. The long t
shortly after taking their medication which will detect and document that the appropriate medication was taken at the proper time. This te
do not target specific sites; rather show vascular distribution and breakdown of normal barriers. The compounds developed here will begi

a concentrations of bilirubin do not correlate well with bilirubin encephalopathy in newborns, which contributes to the uncertainty in the m
T1 peptide via milestones outlined in this SBIR, not only will meet this specific need for patients and surgeons, but also has the potential to

he performance of human interpreters, including professional in-person interpreters, telephone-based interpreters, and ad hoc interpreter

process; staff development workshops; and the ESSP Best Practices database. In 5 treatment schools, ESSP teams comprising parents, scho

turbation method that offers instant validation, through addition of an inducer chemical, of the causal relationship between the observed p
emaining performance problems. The long-term goal is to become a main supplier of new high-quality low-noise miniature preamplifiers fo
ddress whether simple blood measurements of these receptors may reliably predict the mAR:AR ratio in androgen's target tissue. The seco
ro and in vivo data) will be chosen to take into preclinical toxicology testing.
can be manufactured at a substantially reduced cost compared to existing valves. In summary, the valve proposed in this research will lead

care personnel; n=120 nursing students) that evaluate the effectiveness of the effort. Pressure ulcers are a significant problem in long-term
he compounds identified in Phase I. Phase II will also study the mechanisms of the compounds identified for the development of target-bas
mpound safety. Phase III of the project will be focused on establishing a commercial screening service for photoreceptor toxicity. Even with

atile methodology is proposed for tailoring carbohydrate-functionalized nanoparticles (i.e. glyconanoparticles) with 3D polyvalent carbohy

functionally superior to all currently available conventional prehensors. To ensure success with parents as well as children, ADA will include

ecovery of islets of Langerhans. Aim 2. Identify and assess initial performance profile that will be utilized for device optimization. Aim 3. Com

d for clinical trials in breast cancer during phase II. The first step will be to generate a mouse-human chimeric Mab from the mouse Mab ca

a is especially hard on African Americans due to a variety of factors including air quality and access to medical care. One of the most popu
alaria usually strikes populations that are least able to afford medicines. This project seeks to develop, validate, and commercialize a new, c

e noninvasive sleep detection/restriction will assist researchers from other disciplines to link their specific topics, such as cardiovascular, m
ve assay system to be developed in a Phase II study. 7. PROJECT NARRITIVE Millions of people suffer Alzheimer's disease and other dementi
erous human diseases.
ery. Arising from the establishment of pathogenic biofilms on device surfaces, these infections not only necessitate new surgeries but in th
ses of recombinant BMP-2. Growth factor and osteoblast binding peptides will also be tested alone and in combination to assess their abili

tervention in high-risk populations AFrame has developed a prototype wearable, low-power, form-friendly, wireless, wrist-based device tha
positions Agenta to fulfill the objectives of this proposed project.
olumetric magnetic resonance imaging in a university collaboration, by histomorphometric analysis of new bone, new periodontal ligament
content with existing and proposed human physiology textbooks; and 5) broaden participation by making the technology more affordable f
ility is high. At the end of the proposed research and development, the project will deliver a working prototype of a personal portable parti

pioid neutral antagonist for treatment of adverse opioid effects, thereby decreasing morbidity and mortality associated with pain managem

nimal studies. The objective of this research is to generate re-shapable, delayed-expansion, hydrogel-based tissue expanders for use in dent
pe on neat and amended nasal swabs, throat swabs, nasal lavage and/or sputum clinical samples in accordance with 510K submission guid
rument.
pumps can do a very good job on a single small chamber. However, the rise of high-throughput systems which require multiple identical p
es proposes to develop a detector system for a high sensitivity multi-well plate reader based on an array of our CMOS photon counting Gei

on, high spatial resolution, high X-ray absorption efficiency, and rapid decay time with no afterglow range widely - from macromolecular cr

le to scientists which is currently not available.

nd perseverative behavior on the Morris Water Maze following binge alcohol exposure. With over 8.5% of the population meeting the diagn

s with known findings and outcomes. The most similar known masses are retrieved and displayed nearly instantaneously for the radiologist
inical therapy studies. Refinement of the peptide-targeted a-therapy approach through nuclear localization of radionuclides should result i

sults of this research will be practically applied to protect public health and enhance medical treatment.

ation can be overcome by using a newly developed method based on mass spectrometry of in vitro expressed proteins (MASSIVE-PRO). Du
al laboratory environment and for eventual FDA approval, AmberGen will work closely with Quest Diagnostics, Inc., which operates the larg
sity of Alabama and a world leader in NF1 testing using a repository of validated genomic DNA and mRNA samples from NF1 patients. Clin
nal molecular information that may overcome limitations of the direct observation of cancer cells by a pathologist. This should result in few
oratory workfow and reducing costs. The overall goal of this proposal is to develop an assay to detect mutations that are important for de
y data regarding the ability of this Met and Tie2 antagonist to ameliorate RA in animal models. The primary focus of this proposal is the dev
efanalin in SCI. Dose-response, treatment time window and dosing schedule studies for Refanalin will be followed by determination of Refa

rgeting S. typhimurium auxotrophic strains and chemotherapeutic agents as well as radiology will also be tested in the Phase II application

nduct definitive animal studies of efficacy, dosing and toxicity. Psoriasis is a chronic skin disease affecting approximately 2% of the worldwi

of ocular disease. This will provide rapid evaluation of the first-in-class inhibitor of this innovative molecular target.
o further augment this response by eliminating T effector cells and/or expanding T regulatory cells, thereby creating donor specific immune
s to deliver such molecules to cells of interest expressing receptors for the chimeric proteins. The Principle Investigator of this application re

xperiment screening and will be the instrument of choice for both large consortiums and medium-size research laboratories. Protein str

ug display intended for anesthesia care providers. This display is intended to help anesthesiologists visualize a patient's level of sedation an

doing, it can lead to assessment not only of water quality, but also of the implications of chemicals and environments for human health.
at, etc. It is predicted to provide both acute symptomatic relief by virtue of it's physical strength and long term benefits by virtue of the dru

and the workfow-based liquid sample tracking database will be built and integrated with the storage cartridges and precision dispensing e
his information is a daunting task, since it is scattered among thousands of scientific publications and reports. In this proposal we outline h

tivity. This novel drug, designated AGT-180, will be a model for the treatment of the brain for multiple genetic diseases. 1

being of animals by reducing the dosing frequency and stress to the animals, and save considerable time for veterinarians and their staff tre
 thods that are essentially unchanged in the last five decades. The tests are usually conducted by highly trained professionals in expensive s
tion of the linear precursor. Using CES, the assembly of modified cyclic peptides is simplified considerably and can be done at a cost compati

ns. The goal of this project is to develop therapeutic agents for pulmonary fibrosis which currently lacks effective treatments. The novel ant

the ability to move muscles or to feel normal sensations. [The product that would result from a successful project would be an unmatched
to public health, as our research attempts to find treatments for the side-effects of chemotherapy. Such treatments may lead to more effic

tion. These data will be used to support a pre-IDE application to the FDA. The deliverables of this Phase II project are two quality-assured EL

and thereby automate the assessment of GMs. Based on the proposed multi-phase research program, the requisite knowledge will be obta

pulation that might not otherwise seek and/or receive services by other means.
ental health professionals to prevent and reduce the risk in the vulnerable and rapidly growing population of Hispanic adolescents of seriou

-VLC training. The hypothesis to be tested is: the adaptive response to 16-weeks of PRT will be greater for the VSC-VLC group than the SC-L
to establish the pharmacokinetics of a solid dose, and provide comparisons of different formulations within the same subject. When succe

with procedure planning, probe placement, placement verification, and often necessary readjustments. In addition to increasing patient com
ta, a step in laboratory practices workfow management not yet fully accomplished in this industry. Achievement of milestones linked to the
mutation that greatly enhances the polymerase's affinity for dideoxy terminated oligonucelotides (ddNTP) (US patent 5,614,365) is more effi
A kits under the name REPLI-g(r). A major problem of the PCR-based methods is incomplete coverage of the genome due to amplification
oring of cardiovascular disease states relative to national efforts to prevent, detect and control hypertension. The technology from this proje
phenotypes. It will be applied in hospital diagnostic work, environmental diagnostic work, bioterrorism monitoring, new drug developmen
o emergency medical personnel and trauma clinicians along with battlefield medics. Also, it would be useful for patient monitoring in a card
k and hemorrhagic shock each year. Trauma injury resulting from automobile accidents, bullet or knife wounds and falls is the primary reas
or filing an Investigative New Drug (IND) application to start studies in human volunteers. In an age of speed, civil violence and armed confi
tide antigens expressed in bacteria. Anti-peptide polyclonal antibodies are important reagents for the detection and characterization of pro
f greater specificity and the improvement of sensitivity that we can achieve, this approach could lead to the development of a single tier as

se infammatory reactions that adversely affect the quality of life. In particular, a protein called TNF is known to be responsible for pathoge

rence tomography (CAS-OCT) scanner for use in clinical and applied research applications. This imaging system will be able to image the fu

s should find broad applications in the general study of cell and molecular biology as well as in high throughput screening of drug candidate

autism, Parkinson's disease, and stroke. Augmentative and Alternative Communication (AAC) devices that are operated via switches, keyb
ddress the complexity of the GI microfora, namely clinical IBD expertise, environmental microbiology expertise, and bioinformatics experti

junction with an insulin pump improve overall health level of people with diabetes by enabling autonomous blood-sugar control with mini

is software as a stand-alone component for manual patch clamp systems. Developing drugs that target ion channels has been hindered by
devices for low vision by improving on and surpassing the capabilities of the traditional optical telescope, greatly benefiting persons with r

ncreasing productivity, and improving the quality of life for millions. Brighton Technologies Group, Inc.'s Antimicrobial Nanocoating is desig

ative, unmodified proteins and reagents without the need either to label the drug or to tether the protein. This measurement technique e

ALS and Lou Gehrig's disease, affects ~87,000 patients worldwide with about one third of these patients residing in the United States. ALS
of the underlying disease. We propose to identify potential new medicines that will suppress or reverse the underlying Parkinson's disease
of doxorubicin designed for use against lymphoma. This proposal presents a novel potential therapeutic for use in lymphoma treatment, bu

d roles of Th1/Th2 immunity, HUCBC transplantation, and AD pathogenesis. This knowledge is used to rationalize U-CORD-CELL" as a poten
may be performed from single pancreas donations resulting in cost savings due to removal of patients from chronic dialysis, reduction of d

intervention, and the development of increasingly relevant paradigms for drug discovery. As a result, we foresee that these toolsets will sig
t is to develop and make commercially available a new powerful research tool: a set of functionally validated genome-wide human and mo
e-wide functionally validated siRNA libraries designed for high-throughput discovery of novel drug targets. The developed bioinformatics to

opulation of ventricular-CMs will not only have significant commercial impact on cardiac safety testing, but these cells may provide opportu

reatment without the long wait for broad spectrum, expensive testing in large clinical laboratories.

esearch involves the synthesis of macrolide neoglycosides and their evaluation as anti-bacterial and anti-viral agents, to identify compound
mical variations of the sugar components of cardiac glycosides that have been used for centuries to treat congestive heart failure. In the pre
a pancreas transporter and pancreas perfusion protocols will permit utilization of most, if not all, pancreases suitable for transplantation in

data and CCi's data on estrogenic activity on many chemicals to identify which chemicals have anti-estrogenic activity and to work with var
e new anti-angiogenic drugs should have great commercial potential. Retinal neovascularization is a major pathological change leading to v
OIR rats. K5 also inhibits endothelial cell migration, which is a critical process in angiogenesis. The goal of this phase I project is to develo
no effective drug treatment for diabetic macular edema. The goal of this project is to develop a novel, more effective, less toxic thalidomide
stable, and have long shelf lives. Furthermore, these features also make this type of test ideal for epidemiological investigations.
NA from tumor cells. Clinical evaluations are envisioned to be performed in the Phase II project.

rch will create a low-cost, easily-distributed and easily-replicated method for assessment and adjunctive management of AABCP.

the MPPS accurately captures PD symptoms and differentiates between PD and non-PD subjects. Specifically, for Phase I we will integrate p
ment of the impedance of BBB by the use of a ramp of different frequencies. We propose to develop and validate an improved dynamic in v
elp informal (unpaid) dementia caregivers: determine what educational content is best suited to their needs; identify and track symptoms
Group and MultiWeb Communications, its parent company, will market the educational program to multiple national audiences. Suicide, su

y cytokines like Interleukin-6 (IL-6). We have previously reported that COG133, a novel anti-infammatory peptide derived from apolipoprot

nions when cement eventually separates from the bone. The long-term goal of this project is to create a resorbable, small bone adhesive w
s, occurring in up to 50% of certain surgical procedures. The long-term goal of this project is to create a sprayable surgical adhesive which

h communication between persons with different native languages in the U.S. and throughout the world.

batteries put together in the form of a belt (weight of this belt is estimated to be less than 4 Kg), 3) it will be low power consuming ( less th
dwindling access to multidisciplinary treatment programs, the need for alternative, cost-effective interventions is great. The purpose of the
ar modeling vendor. Interfaces with existing MD codes and visualization software will also allow alternate distribution paths. Health Related

ce was shown to be mechanically robust, easy to place and use, and able to successfully transport a dentate bone segment across a 2 cm b

erson from the foor. Both of these transfers are common in everyday living and can cause serious injury to the caregiver or patient if not do

cs that provide care to individuals following stroke. customKYnetics, Inc. will seek a Strategic Alliance partnership with NuStep, Inc. for man

herapeutic decision time.

o proteins that are not amenable to standard NMR methods or to crystallography. We believe that the method to be fully developed here m
ettings for individuals with Asperger Syndrome and/or High-Functioning Autism (AS/HFA). STRIVE will be an innovative, skill-building resour
 stated that, "Children with a chronic disease face a lifetime of careful health management requirements and lifestyle adaptations to preve
the burden of worrying about the well-being of the person with BPD, are a few of many difficult issues for family members. The Living with
's Guide, video program, and accompanying CD-ROM. Once these components are developed, we will conduct a full-scale outcome evalua

That misconception overlooks the millions of currently employed people caring for a family member with the disease. Alzheimer's Cost to U

nc. (DGI), a small biotech startup company. Successful treatment of Fanconi anemia using DGI's transposon system is intended to provide p

ng severe morbidity and considerable economic losses. This project is structured to identify desperately needed drugs to combat filarial ne

he ability of scientists to design DNA probes that yield consistent, positive results, and avoid costly (or deadly) false negative results.

solution. For the more common field of 7 T, S/N gains will be even greater.
f the first year in Phase II. There is strong medical and scientific interest in determining the structures of the 15,000 membrane protein

es, drug delivery components, implantable components, lab-on-a-chip devices, micro total analysis systems (f-TAS), and MEMS (MicroElectr
on human infants. The EchoMRITM system for infant BCA will be non-invasive, precise, and safe for pediatric populations, as it will not rely
eases. This information will be necessary to generate standards for conversion of proteolysis activity into a simple yes-or-no readout (visibl

nd the host infammatory response in vivo (Aim 3).

agram quantities of a potentially important new anti-HIV agent. At the end of the Phase II project, at least 20 grams of purified SLPI will be

programs based on individual needs. In addition, the proposed programs will serve as a model for the development of future IM programs
echnological improvements proposed would bring considerable benefit to the biomolecular research community.
result in continued high technology job losses to other nations. Early and sustained science education will provide noteworthy societal ben

tivity to existing approaches.

nown antibiotics; their commercial development will depend upon details of their structures, to be determined during this SBIR Phase I pro

icable through scientific studies. This approach can bring important benefits by effectively leveraging scientific knowledge into benefits for
mportant benefits by effectively providing a single source compilation of AOD data in a manipulate-able format for local planners.

he foundation for the development of a fast, multi-pixel optical assay system for intraoperative assessment of tumor margins in patients un

the importance of its continued public support, and enable members of the public to make informed personal decisions when presented w
n of the system will be demonstration of placental transfer of D-specific antibodies in sensitized females by testing erythrocytes from their

armaceutical testing of new drugs. In Phase II we plan to test the device on at least 1,750 individuals at 4 different clinics. Chronic obstructi

ith this disease which is made even more complicated by the intracranial location and subsequently the prognoses is poor. The proposed re
sed and poorly understood ocular surface disease that affects the quality of life of over 25 million Americans, especially women and the ge

vent opportunistic infections, to place drug-naive patients into cohorts prior to therapy, and to monitor the effects of anti-retroviral therapy

g chiral compounds in seconds, can potentially replace chiral chromatography for chiral analysis time is a critical consideration. Rapid enanti
market of $70 million. The long term objectives of the investigators are to develop breath-based detection technology to enable medical di
taken at the proper time. This technology should improve adherence rates, especially in high-risk populations.
pounds developed here will begin to address these issues by identifying promising compounds in vitro that can be used to test for efficacy

butes to the uncertainty in the management of jaundiced infants. To address this problem, a new bilirubin assay will be developed to deter
ons, but also has the potential to lay a platform for broader clinical applications and commercial opportunities.

erpreters, and ad hoc interpreters such as friends and family of the patient and non-clinical bilingual hospital staff.

P teams comprising parents, school staff, and administrators will implement the ESSP MAP for one school year with all low achieving 3rd, 4t

tionship between the observed phenotype, in this case HIV resistance, and the perturbed gene. The repopulation of RHGP integrated cell c
-noise miniature preamplifiers for the MRI hardware industry.
ndrogen's target tissue. The second aim will test the predictability of the mAR:AR ratio on the therapeutic outcome of androgens by assessi
roposed in this research will lead to a new generation of replacement heart valves that improves upon the shortcomings of existing replace

a significant problem in long-term care. The number of individuals receiving long- term homebound care has increased rapidly in the last de
or the development of target-based assays to further screen novel compounds. In Phase III we will partner with corporate collaborators wh
photoreceptor toxicity. Even without formal regulatory adoption, the ability to accurately predict toxic potential will provide a compelling se

cles) with 3D polyvalent carbohydrate display and globular shapes. This methodology allows the preparation of glyconanoparticles with bio

well as children, ADA will include market-driven cosmetic features in addition to adaptive grasp, VMA, and passive holding capability. The P

r device optimization. Aim 3. Compare novel sonic approach to current islet cell dissociation method. Our team has more than 2 decades e

ric Mab from the mouse Mab candidate selected during phase I. This chimeric Mab will then be taken further into pre-clinical developmen

dical care. One of the most popular tools in the treatment of asthma is the metered dose inhaler (MDI), a small aerosol canister filled with d
date, and commercialize a new, cheaper method for producing the highly effective malaria drug artemether from the Sweet Wormwood pla

topics, such as cardiovascular, metabolic, endocrinological immunological, and neurobehavioral areas with the fundamental sleep homeos
mer's disease and other dementias, yet there are no preventive medicines and effective treatments. To develop better therapies, we need b

cessitate new surgeries but in themselves present a significant threat to life and limb. The biofilm bacteria that establish themselves on me
combination to assess their ability to increase bone formation compared to untreated TCP by promoting the attachment of endogenous gr

wireless, wrist-based device that provides the following functions: (1) Body Temperature (2) Pulse Oximetry (3) Heart Rate and (4) Location
bone, new periodontal ligament, new cementum, and immunohistochemical measurement of osteocalcin at a 3 week and 12 week post-su
he technology more affordable for economically disadvantaged schools. The research proposed for Phase II is highly relevant to general pu
type of a personal portable particulate matter sensor and the data measurement infrastructure. Experiments to calibrate the sensing and e

y associated with pain management.

tissue expanders for use in dental and reconstructive surgery. These tissue expanders will overcome problems associated with current tech
ance with 510K submission guidelines; and begin cartridge production scale-up in collaboration with Quidel. The Diagnostic Respirator

hich require multiple identical platforms of cultured tissue mean that pump based systems would require a lot of pumps. This is problemati
f our CMOS photon counting Geiger mode avalanche photodiodes. The proposed detector will have improved functionality over existing de

widely - from macromolecular crystallography to medical imaging, and from nondestructive testing to polymer research. As such, the comm

he population meeting the diagnostic criteria for alcohol use disorders (AUDs), alcohol use and abuse are one of the nation's major public

stantaneously for the radiologist to review. During our Preliminary Study this software system was optimized for the diagnostic breast ultra
n of radionuclides should result in improved therapeutic efficacy at potentially lower doses due to higher cell killing efficiencies. Peptide tar

sed proteins (MASSIVE-PRO). During Phase II, a HIV-1 genotyping drug-resistance test with sensitivity for drug resistant subpopulations of v
tics, Inc., which operates the largest network of in vitro diagnostic testing facilities in the U.S. All results will be statistically analyzed in colla
samples from NF1 patients. Clinical beta-testing will be performed during the third year in Dr. Messiaen's laboratory. In addition, Quest Dia
hologist. This should result in fewer missed tumors and may be able to reduce the number of ambiguous diagnoses.
ations that are important for determining treatment of myeloproliferative disorders and leukemia. This liquid bead array format of this assa
 focus of this proposal is the development of small molecules that inhibit SF/HGF/Met and Tie-2 signaling for therapeutic advantage. Our le
ollowed by determination of Refanalin efficacy in clinically relevant models of SCI. Successful completion of the proposed research will enab

ested in the Phase II application. Bacterial therapy for metastatic cancer is described. Genetically-altered bacteria that grow only in tumors

pproximately 2% of the worldwide population. In the US alone there are an estimated 4.5 million diagnosed cases with an estimated annua

ar target.
y creating donor specific immune tolerance, leading to the survival of transplanted islets. Proof-of-principle will be followed by a Phase II ST
Investigator of this application recently developed a novel, proprietary potential cancer vaccine approach based on the use of 4-1BBL chim

arch laboratories. Protein structure is a cornerstone in biological science and medicine providing a molecular basis for disease and drug

ze a patient's level of sedation and analgesia during surgery, resulting in more effective anesthetics and less episodes of inadequate analges

vironments for human health.

erm benefits by virtue of the drug acting on the airway- encroaching tumor cells and on local tissue hyperplasia thus allowing time for othe

dges and precision dispensing equipment (Specific Aim 3).These early versions of the commercial equipment will be Beta tested in a nation
rts. In this proposal we outline how to apply the most recent advances in the information extraction techniques to create and automatically

etic diseases. 1

or veterinarians and their staff treating the animals. If this formulation is successful, it could be used for other laboratory animals with appr
ned professionals in expensive sound-treated rooms. This project is a component of a research and development program to develop effici
nd can be done at a cost compatible with commercial development. Successful achievement of the project goals will allow a considerably b

ective treatments. The novel antagonists developed in this project should be ideal drug candidates for treating pulmonary fibrosis in human

project would be an unmatched treatment option for these patients and would be the only commercially available long graft alternative to
eatments may lead to more efficacious treatments for cancer, as more people will be able to tolerate either higher levels of chemotherapy

roject are two quality-assured ELISA assays for the brain injury biomarkers establishing the foundation toward their commercialization. The

requisite knowledge will be obtained to enable realization of a low-cost, low-profile GEMINI product that can reliably perform the required

of Hispanic adolescents of serious mental health and behavioral problems through effective assessment of abnormal levels of stress.

the VSC-VLC group than the SC-LC group as measured by the maximum voluntary leg extension strength during standard one-repetition ma
n the same subject. When successive doses represent a marketed or generic drug, the pig will provide drug bioequivalence data. Demonstr

ddition to increasing patient comfort, this reduced procedure time presents significant cost savings that will make breast MRI more availab
ement of milestones linked to these Specific Aims will mark the end of Phase I and commencement of Phase II, where LabmatrixTM will be
US patent 5,614,365) is more efficient at performing PAP than the wild-type polymerase. We have performed preliminary tests with a Bacil
he genome due to amplification bias of PCR reactions over certain loci (e.g., GC rich regions). MDA is based on the strand displacement acti
n. The technology from this project is expected to improve clinical diagnostic methods involving physiological fuids such as blood and urine
onitoring, new drug development, toxicology studies, and in many areas of basic biology research.
ul for patient monitoring in a cardio-thoracic ICU or critical care units. The combined market for these applications is quite large. With furth
unds and falls is the primary reason for development of hemorrhagic shock, and is the leading cause of death for individuals under the age
d, civil violence and armed conficts, the incidence of penetrating and blunt injuries to the abdomen has been on the increase. On average,
 ction and characterization of proteins in cells and other complex biological systems. The exquisite specificity of anti-peptide antibodies has
e development of a single tier assay to detect antibodies against any of the three pathogenic genospecies of B. burgdorferi in both early an

wn to be responsible for pathogenesis of infammatory diseases, and therapeutic drugs designed to inhibit TNF have been quite successful t

tem will be able to image the full depth of the anterior segment (> 6mm) by developing a novel approach to complex conjugate artifact rem

hput screening of drug candidates.

are operated via switches, keyboards, and a broad range of other input devices, and that have synthetic speech as output, are often the on
rtise, and bioinformatics expertise to analyze complex sets of data. New diagnostic tools based on LH-PCR can be utilized for routine real-ti

us blood-sugar control with minimal user intervention. The overall result will be a healthier life for people with diabetes and lower medical

channels has been hindered by the expense of the consumables used in automated patch clamp screening devices. We propose to develo
greatly benefiting persons with reduced visual acuity, reduced contrast sensitivity, or other loss of visual function caused by macular degen

ntimicrobial Nanocoating is designed to render medical device and hand-contact surfaces self-sterilizing to eliminate some the most commo

This measurement technique eliminates the experimental biases introduced by existing technologies. The primary experimental biases to

esiding in the United States. ALS patients generally survive only 3 to 5 years following the onset of the disease. Riluzole, the sole currently c
he underlying Parkinson's disease process, and as a result improve the health and lifespan of people with Parkinson's disease.
r use in lymphoma treatment, but the technology can be more broadly applied towards the improvement of safety and efficacy of many ch

nalize U-CORD-CELL" as a potentially safe and effective immunomodulatory therapy for AD.
m chronic dialysis, reduction of diabetes associated morbidity, and the transition of islet transplantation from an emergency procedure to a

oresee that these toolsets will significantly improve the efficiency, economy, and ease of performing HTS of lead peptide compounds, and w
ed genome-wide human and mouse lentiviral siRNA libraries designed for high-throughput discovery of novel drug targets. We propose to a
The developed bioinformatics tools and technologies will significantly improve the efficiency of translational research related to molecular

these cells may provide opportunities for development of new assays to be used in the cardiac drug discovery process as well as provide a

ral agents, to identify compounds that could be developed into valuable new anti-infective drugs.
ngestive heart failure. In the present study the goal will be to identify drug leads that have the greatest safety index between antitumor ac
es suitable for transplantation in the U.S. Furthermore, the PTR may permit islet isolation banking for long-term storage. Banking would allo

enic activity and to work with various firms to design consumer products that are free of chemicals that release anti-estrogenic or estrogen
pathological change leading to vision loss in diabetic retinopathy, which is a leading cause of blindness in the world. Our goal is to develop
f this phase I project is to develop a novel, non-viral K5 gene delivery system that is safe, has strong tissue specificity and long-term express
e effective, less toxic thalidomide analog for clinical trials to treat diabetic macular edema. In Phase I, we have compared the efficacy of a s
ological investigations.

anagement of AABCP.

lly, for Phase I we will integrate prototype hardware, design algorithms for clinical feature extraction, develop a software interface, and con
alidate an improved dynamic in vitro blood-brain barrier (DIV-BBB) model that reproduces the functional characteristics of the BBB in vivo,
ds; identify and track symptoms of dementia in their loved ones; make educated decisions about health, caregiving, financial, legal, living a
le national audiences. Suicide, suicidal behaviors and suicidal ideation are underidentified prevalent problems with significant morbidity an

eptide derived from apolipoprotein-E, could reduce IL-6 levels in the brains of whole animals. We now propose to test whether COG133 ca

sorbable, small bone adhesive which would satisfy the surgical need for a method of bone fixation that permits bone regrowth while main
rayable surgical adhesive which would satisfy the surgical need for a strong, easy-to-use adhesive to coapt planar faps of tissue. This novel

be low power consuming ( less than 250 watts), 4) pulsed introduction of the exhaled breath for sensitive detection (ppb range) of chemica
tions is great. The purpose of the proposed project is the development of one such alternative, the Pain Self-Management Program (PSMP)
istribution paths. Health Relatedness and relevance to Mission of the NIGMS Institute. This effort addresses the growing need for fast and

te bone segment across a 2 cm bony gap in a live goat model. The objective of Phase I of this STTR proposal is to determine optimal dimen

the caregiver or patient if not done properly. The LifterMate will improve the quality of life for both caregivers and patients with a creative

ership with NuStep, Inc. for manufacturing, marketing, sales, and distribution of the FES-augmented TRS4000 with the goal of achieving a p

hod to be fully developed here may provide a break-out technology in a variety of important arenas in structure-based biomedical research
n innovative, skill-building resource designed specifically for late adolescents and young adults, ages 16 to 21, with AS/HFA as they transitio
nd lifestyle adaptations to prevent or manage related health complications. Interventions that make a difference in childhood disease self-m
amily members. The Living with Borderline Personality Disorder is an educational video series for family members that provides them with
duct a full-scale outcome evaluation with students and teachers to determine the effectiveness of the MSC program in increasing knowledg

he disease. Alzheimer's Cost to U.S. Businesses: Caregiver absenteeism: $ 7.89 billion, Productivity loss: $13.22 billion Replacement of care

n system is intended to provide proof of principle for the potential application of this technology to the treatment of other disorders of the

eeded drugs to combat filarial nematodes, which constitute the most significant of the human tropical cluster diseases. Filarial parasites cau

dly) false negative results.

of the 15,000 membrane proteins in the human body over the next decade, though available NMR and X-ray methods work poorly and hav

(f-TAS), and MEMS (MicroElectroMechanical Systems) for biomedicine, biomedical analysis, diagnostics, and treatments. The proposed tec
c populations, as it will not rely on ionizing radiation. The measurements will be easy-to-perform and exceptionally fast, with a whole-body
simple yes-or-no readout (visible by a color change) that will be used in the diagnostic device. Overall, the studies in this proposal will imp

20 grams of purified SLPI will be provided to the Mayo Clinic HIV Research Center for preclinical testing (see attached letter from Dr. Andre

elopment of future IM programs for individuals with high incidence disabilities.

munity.
provide noteworthy societal benefits, including scientifically literate future voters. One can anticipate that continued early introduction to s

ined during this SBIR Phase I project. The product of this Phase I research will be a lead compound for treating infections by drug-resis

tific knowledge into benefits for youth and society.

mat for local planners.

of tumor margins in patients undergoing breast cancer surgery. The optical assay system will have significant clinical benefits including: (1)

onal decisions when presented with a decision about whether to use a drug of abuse.
testing erythrocytes from their fetuses or neonates for bound anti-D by the direct antiglobulin test (DAT) and elution of anti-D. The long-te

fferent clinics. Chronic obstructive pulmonary disease (COPD) is fourth leading cause of death in the United States; and respiratory screenin

ognoses is poor. The proposed research will focus on establishing a novel, highly concentrated, gene based therapy for the treatment of bra
ns, especially women and the geriatric population. Common to all etiologies is a decrease in both volume and quality of tear secretion, but

e effects of anti-retroviral therapy. It is currently recommended that a CD4 assay is performed on every HIV infected individual every 3-6 mo

itical consideration. Rapid enantiomeric excess measurement is essential in drug discovery process and QA/QC of pharmaceutical products
technology to enable medical diagnostics as sheltered by intellectual property licensed from the University of Florida.

can be used to test for efficacy in mouse models of atherosclerosis in Phase II.

assay will be developed to determine the plasma concentration of free unconjugated bilirubin, which is a better indicator of risk of neurolo
al staff.

ear with all low achieving 3rd, 4th and 5th graders. Trajectories of standardized test scores will be used to compare the academic performa

ulation of RHGP integrated cell clones survived from infection-induced killing indicates that the targeted gene products are not essential to

utcome of androgens by assessing if the negative outcome associated with androgens in an animal model of stroke is correlated with a rela
shortcomings of existing replacement valves, reduces the cost burden on the health care system and improves the survival rate of patients

as increased rapidly in the last decade. Home health aides represent the fastest growing occupation in the U.S., with a projected growth rat
with corporate collaborators who can take these compounds into and through human clinical trials as an essential step in addressing a hug
ntial will provide a compelling service to chemical companies and will represent an important step in protecting human health. The averag

n of glyconanoparticles with biologically significant carbohydrates. The glyconanoparticles can be used as efficient affinity labels as well as

passive holding capability. The Phase II effort will leverage this technology to create an entity that will be attractive to Phase III investors. D

eam has more than 2 decades experience in device fabrication and testing for the isolation and perfusion of cells for research and transpla

her into pre-clinical development. This and other development activities will serve as the basis for a Phase II SBIR application as a basis for t

mall aerosol canister filled with drug and propellant which administers a puff of medicine for inhalation; this popular device has been used
r from the Sweet Wormwood plant.

the fundamental sleep homeostatic regulation. This scalable instrumentation will ultimately facilitate sleep behavior phenotyping in trans
elop better therapies, we need better testing technology. Here we propose to develop an automated touchscreen-piezo toolkit for testing d

that establish themselves on metal hardware are essentially impossible to eradicate by any means except explantation. Methods that decre
he attachment of endogenous growth factors and osteoprogenitor cells. Bone grafting is routinely necessary prior to the placement of dent

ry (3) Heart Rate and (4) Location Information. AFrame is currently working to add further vital signs capability, specifically (1) Blood Pressu
at a 3 week and 12 week post-surgical time point. Expression of the Perlecan D1 transgene will be assessed locally and systemically while s
I is highly relevant to general public health. Health science apathy, increasing at a societal level, is often rooted in K-12 science education fa
nts to calibrate the sensing and evaluate the data collection mechanisms will be conducted. The instruments will be ready for field trials in

ems associated with current technology such as eliminating exterior equipment and allowing custom fitting of the expander to the tissue b
el. The Diagnostic Respiratory Protein Array test cartridge will represent a low-cost, simple diagnostic tool for identifying individuals inf

a lot of pumps. This is problematic because for example a 96 well plate would need 192 pumps to provide each well with an input and outp
ved functionality over existing detectors and will have lower cost.

mer research. As such, the commercial potential for this sensor is particularly high. We and our collaborators at the APS believe that due to

one of the nation's major public health problems. Currently approved pharmacological treatments have only targeted the craving aspect of

ed for the diagnostic breast ultrasound examination to standardize interpretation. Our goals for Accuracy, Sensitivity and Specificity were ex
ell killing efficiencies. Peptide targeted alpha-therapy for metastatic melanoma has the potential to provide tumor-specific and efficacious t

rug resistant subpopulations of virus under 5% will be developed and extensively tested.
l be statistically analyzed in collaboration with Prof. Josie Dupuis, Associate Professor of Biostatistics, Boston University School of Public He
aboratory. In addition, Quest Diagnostics will work closely with AmberGen in order to assure these NF1 tests are properly designed for the
iagnoses.
uid bead array format of this assay will provide efficiency and cost benefits to diagnostic laboratories and provide crucial information to phy
or therapeutic advantage. Our lead compound, Ang797 demonstrates highly innovative approach to the treatment of Rheumatoid Arthritis
the proposed research will enable submission of an Investigational New Drug Application to Food and Drug Administration FDA for clinical

acteria that grow only in tumors and destroy them are being developed. Both bacteria and tumors are engineered to fuoresce different co

d cases with an estimated annual cost of care between $650 million and $4.7 billion. Unfortunately, most of the current treatment options

e will be followed by a Phase II STTR application to further develop ApoFasL into a lead product by testing its efficacy in a pig-to-nonhuman
based on the use of 4-1BBL chimeric molecule conjugated to biotinylated TAA antigens. In preliminary studies, this novel vaccine showed po

ecular basis for disease and drug action. The technology advancement described in this proposal, and built into a protein crystal detection

s episodes of inadequate analgesia experienced by the patient.

lasia thus allowing time for other anti- cancer therapies to work and improve survival times.

ent will be Beta tested in a nationally known genetics core resource laboratory. During Phase 3 using other funds this fully developed novel
ques to create and automatically maintain a knowledge base that brings together molecular, cellular, and clinical aspects of drug action me

her laboratory animals with appropriate dose adjustment.

pment program to develop efficient, accurate, automated hearing tests. Automated testing cannot be performed with the earphones most
goals will allow a considerably broader, systemic use of a very potent, broad-spectrum antibiotic and also generate a valuable addition to t

ting pulmonary fibrosis in humans.

available long graft alternative to nerve autograft.]

r higher levels of chemotherapy or longer courses of treatment. The overall number of cancer cases is projected to grow driven largely by a

ard their commercialization. These assays will be used to analyze clinical samples, further confirming the use of the biomarkers as tools to a

an reliably perform the required discrimination tasks and serve as a valuable research tool in documenting and better understanding move

abnormal levels of stress.

uring standard one-repetition maximum SCs, one-repetition maximum VSCs, and isometric contractions. Commercial Opportunity: The pote
g bioequivalence data. Demonstration of the same level of oral bioavailability in the pig and human for marketed drugs would validate the t

ll make breast MRI more available to young women and those with family histories that currently have difficulty with insurance reimbursem
e II, where LabmatrixTM will be readied for commercial launch through continued interactive software development in two test laboratorie
ed preliminary tests with a Bacillus stearothermophilus (Bst) polymerase mutant (F712Y) with similar properties. In addition, some native e
on the strand displacement activity of phage Phi29 DNA polymerase, and uses random oligonucleotides of varying lengths (typically 6-mer
cal fuids such as blood and urine, which need to be processed quickly in advance of a clinical testing protocol.

cations is quite large. With further development, the device may be able to detect other trauma conditions, such as hematoma and hemor
th for individuals under the age of 45 in the U.S. today. The single major cause of death in potentially salvageable battlefield casualties and
en on the increase. On average, nationwide 41.8% of the trauma cases admitted at hospitals are due to road traffic accidents. Also, hemor
ty of anti-peptide antibodies has been used to develop sensitive assays to examine characteristic changes in the proteome associated with
of B. burgdorferi in both early and late Lyme disease.

TNF have been quite successful to alleviate infammatory symptoms including rheumatoid arthritis and infammatory bowel diseases. We h

to complex conjugate artifact removal.

peech as output, are often the only manner in which these individuals can communicate. Without AAC devices, these individuals may suffe
can be utilized for routine real-time clinical use as direct result of this proposal. Such a tool can then be used to help determine the absenc

with diabetes and lower medical costs for diabetes care for the society.

g devices. We propose to develop a method, using machine learning techniques which may increase the success rate of these instruments
nction caused by macular degeneration, diabetic retinopathy, glaucoma, cataracts, and other eye problems.

eliminate some the most common conduits for infection transmission.

primary experimental biases to be removed are labeling and albumin elimination. The significance of Caldera's innovative tool is that dete

ase. Riluzole, the sole currently clinically approved medication for ALS, only extends patient survival by 2-3 months. We propose to identify
arkinson's disease.
of safety and efficacy of many chemotherapeutics in cancer treatment.

m an emergency procedure to an elective procedure.

lead peptide compounds, and will provide both academic and industrial researchers with preferred, cost-effective alternatives to existing s
vel drug targets. We propose to apply this powerful technology to identify novel anti- cancer drug targets. The developed technologies will
al research related to molecular dissection of diverse human disease mechanisms, development of new pharmaceuticals, and therefore, ha

ery process as well as provide a potential cell source for cardiac cell therapy with potential benefit to millions of patients suffering from ad

ety index between antitumor activity and potential cardiotoxicity.

term storage. Banking would allow time for better HLA matching of donors to recipients, off-the-shelf availability, and enable quality assura

ease anti-estrogenic or estrogenic activities.

he world. Our goal is to develop novel anti-angiogenic drugs for the treatment of retina neovascularization. In this project, we will study the
specificity and long-term expression of K5 in the retina. The M ller cells are the major producer of VEGF which is a potent mediator of vascu
ave compared the efficacy of a series of newly synthesized analogs of thalidomide and identified a compound with the most potent effect

op a software interface, and conduct a clinical trial with PD and non-PD subjects. We hypothesize that we can accurately record data, extra
haracteristics of the BBB in vivo, features higher predictability, and is fully scalable and customizable. As such, it will be perfectly suited for e
aregiving, financial, legal, living and options; learn how to perform practical care skills; locate peer support from and communicate with oth
ems with significant morbidity and mortality. These behaviors are increasingly seen initially in Emergency Departments by physicians with li

pose to test whether COG133 can reduce the infammation found in the brains of Tg-SwDI mice that display prominent CAA and neuroinfa

rmits bone regrowth while maintaining strength during healing.

planar faps of tissue. This novel adhesive will reduce fuid accumulation after surgery by eliminating dead space in the wound and maintai

etection (ppb range) of chemicals of present interest, 5) real time and fast data acquisition, 6) wireless data transmission, and 7) capable o
f-Management Program (PSMP), a web-based psychoeducational self-help system for adults with chronic pain. The program is based on fu
es the growing need for fast and accurate computer simulation of biologically important processes. PHS 398/2590 (Rev. 09/04) Page 1 Abstr

al is to determine optimal dimensions for precision manufacturing of smaller, more compact devices for improved treatment and enhanced

vers and patients with a creative solution to a challenge of daily functioning for people with disabilities and their families.

00 with the goal of achieving a price point of $5000. / Relevance Stimulation Augmented Recumbent Stepper for Stroke Rehabilitation App

ucture-based biomedical research. Biomedical research continues to expand the use of detailed atomic-scale structure in developing a deta
21, with AS/HFA as they transition from high school to post- secondary education or work.
rence in childhood disease self-management may set the stage for health outcomes later in life." (2003) We believe that CFFONE, with its
embers that provides them with an overview of BPD, current research on BPD treatments, ways families can learn to cope with BPD and re
program in increasing knowledge and protective attitudes and intentions toward alcohol use. We will also examine the effectiveness of the

3.22 billion Replacement of caregivers who leave: $3.59 billion, Continuing insurance for workers on leave and fees to temp agencies: $1.32

atment of other disorders of the blood as well.

ter diseases. Filarial parasites cause some of the more pernicious nematode-borne diseases known (elephantiasis and river blindness).

ay methods work poorly and have yielded only a few such structures over the past decade. There are more than 4,000 high-field NMR syste

nd treatments. The proposed technology aims to fabricate totally new devices, improve the quality of existing devices, lower manufacturin
ptionally fast, with a whole-body analysis time of about 5 minutes (including subject prep time).
studies in this proposal will improve the assay for pathogen detection and demonstrate that it is suitable to aid in the early diagnosis of wo

e attached letter from Dr. Andrew Badley of the Mayo Clinic). The human protein SLPI was isolated from saliva and shown to reduce HIV re
continued early introduction to science might also stimulate career opportunities for young science students, which in turn, will have a pos

treating infections by drug-resistant Staphylococcus aureus, one of the most serious health problems in the US and worldwide. Infection w

nt clinical benefits including: (1) reduced re-excision rates, (2) reduced tissue removal, which translates to cosmetically-superior lumpectom

and elution of anti-D. The long-term goal of this program is to develop alternatives treatments for preventing hemolytic disease of the new

d States; and respiratory screening for Asthma and COPD, and monitoring of therapeutic interventions are important in US health care. Bec

therapy for the treatment of brain tumors that works to activate the immune system against cancer cells, inhibit tumor angiogenesis and c
nd quality of tear secretion, but there are no approved topical agents that enhance tear production. Our intent is to formulate a lacritin co

infected individual every 3-6 months and more frequently depending on circumstance. The assay described here is intended to answer thi

A/QC of pharmaceutical products as worldwide sales of single-enantiomer compounds made into the pharmaceutical formulations reaches
y of Florida.

better indicator of risk of neurological damage. Clinical use of this assay would enhance the care of jaundiced infants by reducing unnecess
compare the academic performance of students in treatment and control schools using longitudinal techniques for nested data. Implemen

ene products are not essential to cell growth but suitable for HIV-1 drug targets. Most current AIDS drugs target the HIV virus and therefore

of stroke is correlated with a relatively higher abundance of mAR in both the affected brain regions and in white blood cells (the latter serv
oves the survival rate of patients with heart valve prostheses

U.S., with a projected growth rate of 56% over the 2004-2014 period, adding some 350,000 jobs in that same period. Although most home
 ssential step in addressing a huge ($1 billion+) potential market for new AMD therapeutics. PUBLIC HEALTH RELEVANCE: The goal of this SB
ecting human health. The average person in the U.S. contains detectable levels of more than 100 industrial compounds, pollutants, and che

efficient affinity labels as well as for in vivo cellular labeling and imaging.

ttractive to Phase III investors. Due to the small market size, children with upper limb deficiencies are made to get by with prosthetics not s

of cells for research and transplantation and a clinical islet transplantation program with 75 patients transplanted in a five year period. Proj

II SBIR application as a basis for the development of novel biological therapy for breast cancer. Breast cancer remains one of the top three c

is popular device has been used for 50 years, but is going through major changes today due to the phase-out of the use of chlorofuorocarb

p behavior phenotyping in transgenic animals and drug discovery related to the treatment of sleep disorders. 7. Project narrative Modern s
hscreen-piezo toolkit for testing drug effects on animal learning and memory effectively, which will complement to and enhance the curren

xplantation. Methods that decrease infection rates associated with metal implants would clearly benefit society. We propose to develop a
y prior to the placement of dental implants. Natural materials like autograft, bone harvest from the patient, and allograft, cadaveric bone, h

ility, specifically (1) Blood Pressure and (2) Respiratory Rate. As detailed in this proposal, AFrame is also working to add fall detection, gait a
d locally and systemically while safety and toxicity of molecular Perlecan and heparan sulfate delivery is investigated.
oted in K-12 science education failing to be of interest or relevance to everyday life. Collective Simulations, especially when exploring comp
ts will be ready for field trials in environmental studies. The project proposes a research program to design and develop a measurement sy

g of the expander to the tissue by the surgeon. This technology will reduce the incidence of morbidity associated with this surgery thus pro
ool for identifying individuals infected with respiratory pathogens. The underlying platform developed herein will likewise find broad applic

each well with an input and output tube. These pumps often cost $500 each, and the power requirement and foot print for so many would

rs at the APS believe that due to its extraordinary properties, this scintillator will have widespread use in many important synchrotron-base

ly targeted the craving aspect of addiction, an approach that has failed a large portion of alcoholics. Thus, the treatment of alcoholism wou

ensitivity and Specificity were exceeded and the CAIS also exceeded the performance of four expert radiologists. These results represent th
tumor-specific and efficacious treatment of advanced stage disease, which is resistant to current therapeutic approaches.

n University School of Public Health. There exists an urgent need to develop an effective non-invasive method of detecting colorectal cance
ts are properly designed for the requirements of the clinical laboratory environment. Advanced Molecular Diagnostic Test for Neurofibrom

rovide crucial information to physicians and patients for use in making treatment decisions.
eatment of Rheumatoid Arthritis, with significant clinical potential.
g Administration FDA for clinical studies with Refanalin. The primary focus of this proposal is the development of small molecules that regu

ineered to fuoresce different colors such that the targeting of the bacteria to the tumors can be visualized external to the mouse models b

of the current treatment options are either only moderately effective or have significant side-effects. An effective, easy-to-use, low-cost the

s efficacy in a pig-to-nonhuman primate xenograft model. Tolerance to xenogeneic islets will serve as the first step towards the translation
ies, this novel vaccine showed potent stimulatory activity on the innate as well as adaptive arms of the immune system and inhibitory activ

t into a protein crystal detection microscope workstation, is expected to make a significant contribution to the needs of the protein crystallo

funds this fully developed novel system will be introduced to the commercial marketplace. Research laboratories in the U.S. and worldwide
clinical aspects of drug action mechanisms, metabolism, and toxicity. The developed knowledge base can be used as a highly integrated cro
 ormed with the earphones most commonly used for hearing testing. In this project an earphone is being developed that can be used in bo
generate a valuable addition to the current small inventory of drugs capable of treating multi drug-resistant infections. Due to a drastic

ected to grow driven largely by aging population growth, as nearly 80% of all cancers are diagnosed in people ages 55 and older. The Censu

se of the biomarkers as tools to aid in the diagnosis of severe, mild and moderate TBI. Each year in the United States at least 1.4 million p

and better understanding movements and movement precursors for other disorders, such as autism. Identification of movement dysregul

mmercial Opportunity: The potential market for the system is large considering its use in health clubs, wellness centers, physical therapy c
keted drugs would validate the technique, and encourage initial screening in pigs instead of relying solely on human clinical trials for bioeq

fficulty with insurance reimbursements.

velopment in two test laboratories.
erties. In addition, some native enzymes (like the bacteriophage T7 DNA polymerase) have reduced specificity for deoxynucleotide triphos
f varying lengths (typically 6-mer to 8-mer) to prime DNA synthesis. MDA offers isothermal DNA amplification with less bias that PCR based

s, such as hematoma and hemorrhagic stroke.

geable battlefield casualties and in civilian accidents is hemorrhage and hypovolemic shock. Fluid resuscitation is the cornerstone of initial
ad traffic accidents. Also, hemorrhage remains the primary cause of death on the battlefield in conventional warfare. Although, the morbid
n the proteome associated with diseased states. The ability of researchers to develop these assays is currently limited by the availability of

ammatory bowel diseases. We have recently discovered another TNF-like protein named TL1A that appeared to be responsible for both ab

ices, these individuals may suffer from severe social and psychological isolation, and may be unable to lead productive lives. A psychologica
ed to help determine the absence/presence of disease; and predict the various phenotypic presentations of the disease, the disease course

ccess rate of these instruments and therefore lower the overall cost of ion channel drug discovery.

era's innovative tool is that determining protein characterization currently requires significant sample preparations. For example, measurin

months. We propose to identify potential new medicines that will suppress or reverse the underlying disease process in ALS, and as a resu
effective alternatives to existing small molecule libraries. The ultimate goal of the proposed project is to develop and make commercially av
The developed technologies will significantly improve the efficiency of translational researches related to molecular dissection of diverse hu
armaceuticals, and therefore, have major implications for improving drug discovery research.

ons of patients suffering from advanced heart disease.

ability, and enable quality assurance/control procedures to be conducted prior to transplantation. This research program is supported by co

In this project, we will study the effects of two novel CA4 analogs selected from 25 new compounds on retinal angiogenesis in vitro and in
ich is a potent mediator of vascular permeability and angiogenesis. In order to achieve a tissue-specific expression, human K5 has been co
und with the most potent effect on retinal vascular leakage. In this Phase II project, we will further investigate its long-term efficacy, pharm

can accurately record data, extract objective clinical features, and accurately predict between PD and non-PD subjects using multiple objec
ch, it will be perfectly suited for extensive pharmacological and physiological studies. In addition, the use of DIV-BBB can be extended to re
from and communicate with other caregivers via an expanded social network; identify useful local and national resources. In the long term
 epartments by physicians with little or no training in identifying and managing these behaviors. Improved training is needed to help physic

y prominent CAA and neuroinfamation. If COG133 can reduce the brain infammation, it may also improve the behavioral performance of

space in the wound and maintaining tissues in position for natural healing to occur.

a transmission, and 7) capable of multiple analyte measurement or the measurement of ozone alone. Such an instrument is not commercia
pain. The program is based on fundamental cognitive-behavioral principles that have been effectively applied in clinical practice, group inte
8/2590 (Rev. 09/04) Page 1 Abstract Format Page Principal Investigator/Program Director (Last, First, Middle): Boshitsch, Alexander, H Proje

proved treatment and enhanced patient comfort.

d their families.

per for Stroke Rehabilitation Applicant Institution: customKYnetics, Inc. (PI: Hartman, Eric C.) The proposed work may benefit public health

le structure in developing a detailed understanding of the molecular basis for life and for disease. Tools for the identification of means for i
We believe that CFFONE, with its innovative approach for enhancing self-management, has the potential to make that kind of difference in t
an learn to cope with BPD and reasons to feel more hopeful about the outcome for their relative with this disorder. Using the existing techn
examine the effectiveness of the gender-specific approach to alcohol prevention.

and fees to temp agencies: $1.32 billion, Cost of Employee Assistance Programs: $0.0055 billion and Caregiving total: $26.0255 billion. The

antiasis and river blindness).

than 4,000 high-field NMR systems installed world-wide, and annual NMR equipment sales are currently ~$300M. The proposed ultra- hig

ting devices, lower manufacturing costs, and become a more universal rapid prototyping tool.

o aid in the early diagnosis of wound infection. /Relevance The goal of this research is to develop a simple, inexpensive diagnostic device to

liva and shown to reduce HIV replication and block HIV binding to annexin II, a receptor on the surface of macrophages. While SLPI is an att
 ts, which in turn, will have a positive impact on the economic development of our Nation. Page 1

e US and worldwide. Infection with S. aureus is a leading cause of sepsis and bacteremia, as well as pulmonary, skin and soft tissue infectio

cosmetically-superior lumpectomies at the time of the first surgery, (3) better margin assessment leading to reduced repeat surgeries and h

ng hemolytic disease of the newborn (HDN). This need exists because of the diminished supply of Rh immune globulin and concern that blo

important in US health care. Because of its small size, modest cost, ease of operation and sensitivity to small airway function, the proposed

nhibit tumor angiogenesis and can work synergistically with available chemotherapeutics. Positive results from this project will facilitate th
ntent is to formulate a lacritin construct as a topical eye drop that will both stimulate physiologic lacrimal tear secretion and control the und

d here is intended to answer this need, both from the standpoint of addressing the technical difficulties and the cost requirements. It is cu

maceutical formulations reaches $150 billion/year. The proposed system can also be used for the analysis of chiral compounds in complex m

ed infants by reducing unnecessary therapy and improving the identification of infants at risk for bilirubin encephalopathy.
ques for nested data. Implementation fidelity and sustainability will also be evaluated. The proposed project involves implementation of ad

arget the HIV virus and therefore enable the development of drug resistance through viral mutation. This project seeks to identify human h

white blood cells (the latter serving as a surrogate marker for the brain). Successful completion of this project will provide the necessary fo
H RELEVANCE: The goal of this SBIR project is to prove the feasibility of using next-generation, cell-based assays to identify novel cytoprotec
compounds, pollutants, and chemicals, but predicting the risk of this exposure, especially to eye toxicity, is challenging. Current prediction

e to get by with prosthetics not suited to their special needs. This research seeks to develop a functional prehensor designed specifically to

lanted in a five year period. Project Summary Successful application of this project would impact the quality and quantity of islet cells for t

er remains one of the top three cancers to affect and cause mortality in women. Major shortcomings with current treatment are the high le

ut of the use of chlorofuorocarbon propellants (because they harm the environment by damaging the protective ozone layer in the stratos

rs. 7. Project narrative Modern society faces an increasing "sleep debt" which has already begun to affect public health. An accumulation o
ment to and enhance the current cognitive assays.

ociety. We propose to develop a generalizable peptide coating that will promote attachment of multiple antibiotics at point of care to a wid
, and allograft, cadaveric bone, have traditionally been used in these grafting procedures. They have many limitations including complicatio

rking to add fall detection, gait analysis, postural perturbation assessment and activity assessment. The wearable device can be used to co
 estigated.
especially when exploring compelling content (e.g. connecting physiology with nutrition, physical education and substance abuse), are like
and develop a measurement system that will allow public health researchers to do in-depth studies of the impact of environmental eleme

ciated with this surgery thus promoting general public health.

ein will likewise find broad application in many areas of disease surveillance, with an emphasis on point-of-use applications.

nd foot print for so many would make such a system prohibitive. (Not to mention all the moving parts and maintenance etc.) To solve the m

many important synchrotron-based applications. The proposed research will develop and evaluate a unique scintillator that will provide a fa

the treatment of alcoholism would benefit from a pharmacological approach designed to target multiple aspects of alcoholism: neurodege

ogists. These results represent the highest performance for any known ultrasound CAD. This Phase I & II Fast Track grant application ta
utic approaches.

hod of detecting colorectal cancer (CRC), the second leading cause of cancer deaths in the U.S (150,000 new cases and 56,000 deaths). Cur
Diagnostic Test for Neurofibromatosis NARRATIVE Currently more than 100,000 Americans suffer from neurofibromatosis type 1 (NF1) whi
ment of small molecules that regulate SF/HGF/Met signaling to therapeutic advantage. Our lead HGF/SF mimetic, Refanalin recapitulates the

external to the mouse models being used. Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II gran

ective, easy-to-use, low-cost therapy suitable for long-term relief would be a great boon.

first step towards the translation of this novel approach to the clinic for the treatment of T1D. If proven effective, ApoFasL may improve the
mune system and inhibitory activity on T regulatory cells implicated in tumor growth. More importantly, since the last submission of this gra

the needs of the protein crystallography community and public health. It is expected to accelerate the pace by which protein structures are

atories in the U.S. and worldwide store thousands of precious liquid DNA samples but use inefficient and error-prone ways to manage them
e used as a highly integrated cross-domain knowledge resource providing fast and efficient access to the latest information in this field. Co
eveloped that can be used in both automated and manual testing and will significantly increase the efficiency, accuracy, and accessibility.
t infections. Due to a drastic increase in multi-drug resistant infections, in the last two decades, there is an immediate unmet need for

ple ages 55 and older. The Census Bureau has said that two thirds of all people who ever lived past 65 were alive in 2001, and rapid growth

nited States at least 1.4 million people sustain a TBI, of which about 50,000 die, 235,000 are hospitalized, and 1.1 million are treated and re

tification of movement dysregulation can lead to early interventions (e.g., developmental physical therapy) and treatment strategies aimed

lness centers, physical therapy clinics, assisted-living communities, hospitals, and academic institutions. The objective of this research is to
on human clinical trials for bioequivalence. The pig is a valuable model for human illnesses such as diabetes, obesity, and cardiovascular dis

city for deoxynucleotide triphosphates (dNTP) and may thus be ideal for PAP. In Phase I, we will investigate these alternative polymerases i
on with less bias that PCR based methods. In addition, Phi29 DNA polymerase offers the hope of greater fidelity of replication than Taq DN

ation is the cornerstone of initial therapy for nearly all forms of shock, and a critical component of therapy for the critically injured patient.
al warfare. Although, the morbidity and mortality from these injuries are gradually decreasing, abdominal injuries still pose a formidable pr
ntly limited by the availability of high-quality antibodies. In Phase I we will develop a novel, commercially-viable method for high-throughp

ed to be responsible for both aberrant cell death and infammatory reactions in the body. TL1A is believed to be circulating as a soluble pro

d productive lives. A psychologically important feature that no currently available systems have is the ability to speak with the user's voice,
of the disease, the disease course, and treatment effects. If distinct differences between the microfora of controls and IBD are defined as p

arations. For example, measuring drug-protein binding kinetics has previously required labeling of the drug and/or tethering of the protein

ase process in ALS, and as a result improve the health and lifespan of people with this disease.
 velop and make commercially available new, powerful drug discovery tools: a technology for high throughput screening of peptide pharma
molecular dissection of diverse human disease mechanisms, development of new pharmaceuticals and therefore, have major implications f

earch program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their

tinal angiogenesis in vitro and in vivo. This proof-of-concept study represents the first step in developing new anti-angiogenic drugs using t
pression, human K5 has been constructed under the control of a M ller cell-specific promoter, the glial fibrillary acidic protein (GFAP) prom
ate its long-term efficacy, pharmacokinetics, toxicities and molecular mechanisms of action, to obtain essential data for FDA approval and c

PD subjects using multiple objective clinical measures as inputs. The clinical utility of the final Phase I prototype device will also be evaluat
f DIV-BBB can be extended to research applications in Neuroscience. The DIV- BBB can be successfully used to better understand the princi
onal resources. In the long term we expect that DementiaCareCentral.com will improve caregiver knowledge and self-efficacy and decreas
training is needed to help physicians better prevent, identify, assess and manage suicide, suicidal behavior/ideation among their patients. T

the behavioral performance of these animals. Pu

h an instrument is not commercially available at the present time to make any comparison. The R & D during the Phase I will utilize our brea
ed in clinical practice, group interventions, and self-help books. The PSMP has the potential to provide scientifically sound information to la
e): Boshitsch, Alexander, H Project Narrative Relevance to public health Computational simulation of biomolecules from first principles are

work may benefit public health through development of an electrical stimulation augmented recumbent stepping machine (TRS4000, NuS

the identification of means for intervention at the molecular level are of paramount importance. This proposal seeks to continue the deve
 make that kind of difference in the lives of teens with cystic fibrosis. Adolescents with cystic fibrosis are particularly vulnerable to poor adh
disorder. Using the existing technology of video to address this important and overlooked health problem is an innovative concept in that th

iving total: $26.0255 billion. The LightBridge Sleep Behavior Disorders Care Program: (i) improves quality of life for the Alzheimer patient an

$300M. The proposed ultra- high-power NMR probe development is expected to enhance the ability to determine molecular structures of

inexpensive diagnostic device to help clinicians determine if a chronic wound is infected at the point-of-care. By improving the ability for e

macrophages. While SLPI is an attractive target to develop as an HIV therapy, it is currently uneconomical to produce sufficient quantities fo
nary, skin and soft tissue infections, in both hospital and community settings. The rise of multiply drug-resistant pathogens generally, and S

o reduced repeat surgeries and hence, reduced local recurrence, (4) reduced emotional distress, and (5) reduced complications due to redu

ne globulin and concern that blood-derived products are not without risk. This project will provide a unique and accurate model system w

all airway function, the proposed device (APD) can effectively and economically screen for respiratory disease, and monitor interventions in

from this project will facilitate the development of this novel therapeutic approach towards establishing a new treatment option for patien
ear secretion and control the underlying infammation.

d the cost requirements. It is currently believed that lack of such an assay leads to unneeded death due to opportunistic infections. The typ

f chiral compounds in complex mixture for quantification and detection of biomarkers, metabolites and other bioactive compounds in biom

encephalopathy.
ct involves implementation of advanced online SSP and ESSP assessment and Best Practices database features; development of advanced o

roject seeks to identify human host targets (as opposed to HIV virus targets) that will prevent the HIV virus from using the host's cellular m

ect will provide the necessary foundation for a Phase II STTR application and the development of a diagnostic tool to define those individua
says to identify novel cytoprotectants for cells in the retina for treating the dry form of age-related macular degeneration (AMD). Since the
challenging. Current prediction methods require large numbers of animals, are time-consuming and expensive, and do not provide data o

rehensor designed specifically to outperform available devices in both daily use and cosmetic acceptance.

ty and quantity of islet cells for transplantation into type I diabetics and for patients transplanted with islets to treat severe chronic pancrea

current treatment are the high level of side effects induced in patients and insufficient efficacy, particularly for patients with advanced dise

tective ozone layer in the stratosphere); the most popular replacement MDI propellant has been hydrofuoroalkane (HFA), which does not

public health. An accumulation of sleep loss causes excessive daytime sleepiness and impairs cognition, as well as causing long-term impac

tibiotics at point of care to a wide range of metal implants to decrease microbial colonization on their surfaces and ultimately lower implan
limitations including complications associated with autograft harvest; and immunogenicity, risk of disease transmission, limited availability

earable device can be used to collect this data on a short or long-term basis. Future functions envisioned include (1) Cuff-less Blood Pressur
n and substance abuse), are likely to engage students more and to turn them into better-informed, and consequently healthier citizens.
impact of environmental element exposures such as particulate matter, pollutants and toxins on human health. Further, such as system w

use applications.

maintenance etc.) To solve the multiplexing problem we believe we can substitute valves for pumps. Valves are often used in sterile enviro

scintillator that will provide a factor of three higher light than the brightest commercial scintillators, emission in the red region of the spec

spects of alcoholism: neurodegeneration, withdrawal and anxiety. Cannabidiol administration in the appropriate delivery system has these

II Fast Track grant application targets important advancement and more extensive clinical validation of this breast ultrasound tool. The goa

w cases and 56,000 deaths). Current methods for early detection of CRC include the fecal occult blood test (FOBT) and endoscopic colorect
rofibromatosis type 1 (NF1) which is among the most prevalent genetic disorders (~1 out of 4,000 births). An important goal is to develop a
metic, Refanalin recapitulates the biologic activity of HGF/SF by activating the HGF/SF receptor, and represents a highly innovative approach

fter the Phase I and Phase II grant periods are completed.

ective, ApoFasL may improve the quality of life of millions of individuals worldwide with an economic impact in billions of dollars. Xenograft
ce the last submission of this grant we have demonstrated that immunization with SA-4-1BBL plus a synthetic peptide representing the CD

e by which protein structures are solved, and will be a critical mediator of advancement in medical science and drug discovery.

rror-prone ways to manage them. Archivex is developing an integrated system for storing, dispensing and inventorying precious liquids whic
test information in this field. Collected knowledge can also be used as a training set for building toxicological computational prediction mo
ncy, accuracy, and accessibility.
s an immediate unmet need for new antibacterial drugs with novel modes of action. The proposed project will add a potent, efficacious, we

e alive in 2001, and rapid growth of the population age 65 and over will begin in 2011, when the first of the baby-boom generation reaches

nd 1.1 million are treated and released from an emergency department. Current methods used to assess the existence and severity of brai

) and treatment strategies aimed at facilitating normal movement patterns during the critical period of early CNS plasticity. The GEMINI too

e objective of this research is to continue to develop, refine and test a novel computer-controlled strength training system to assist in comb
s, obesity, and cardiovascular disease. Simultaneous pharmacology studies in pigs will accelerate research by providing more relevant infor

these alternative polymerases in pyrophosphorolysis-activated polymerization, helicase dependent amplification (papHDA). Both Bst polym
delity of replication than Taq DNA polymerase because it is a replicative polymerase. Despite this, studies based on highly informative micr

for the critically injured patient. Significant efforts have been made to improve resuscitation fuids in order to protect from the cellular, bioc
njuries still pose a formidable problem, especially in young adults, Early and effective hemorrhage control could theoretically save more liv
put screening of peptide pharmaceuticals in a cell-based assay with a set of genome-wide receptor ligand phage display libraries and transc
refore, have major implications for improving drug discovery research.

s perfusion technology for their future use. Project Narrative: Insulin-dependent diabetes is one of the major health problems worldwi

ew anti-angiogenic drugs using these CA4 analogs.

llary acidic protein (GFAP) promoter. Our preliminary study has demonstrated that the intravitreal administration of these GFAP-K5 nanopa
ntial data for FDA approval and commercialization of this new compound.

otype device will also be evaluated by several movement disorder experts.

d to better understand the principles of brain drug delivery, to acquire relevant knowledge of the BBB anatomy and physiology, and to study
ge and self-efficacy and decrease caregiver burden and depression, ultimately leading to improved outcomes for both caregivers and their
/ideation among their patients. The proposed Phase II STTR will help fill this need and may prevent considerable morbidity and mortality.

g the Phase I will utilize our breadboard instrument to prove the concept of pulsed introduction of contaminated air procured from gas com
ntifically sound information to large numbers of individuals with chronic pain at low cost.
olecules from first principles are revolutionizing man's ability to understand biomolecular behavior and its relation to biological function, an

tepping machine (TRS4000, NuStep, Inc.) indicated for exercise and motor reeducation following stroke (700,000 cases per year) or spinal c

posal seeks to continue the development of a novel approach to structure determination by nuclear magnetic resonance. If successful, this
rticularly vulnerable to poor adherence, which negatively impacts their health status, quality of life and long term survival. CFFONE: A Cell
s an innovative concept in that there are currently no available video programs specifically designed for family members affected by BPD.

f life for the Alzheimer patient and their care providers, (ii) provides less costly care for longer periods of care for families, local, state and fe

termine molecular structures of large, insoluble, membrane proteins by advanced NMR methods by more than an order of magnitude in m

re. By improving the ability for early detection of chronic wound infection, patients will receive appropriate treatment sooner and at a grea

o produce sufficient quantities for preclinical testing. By producing SLPI using transgenic tobacco plants, Edenspace proposes to manufactu
 stant pathogens generally, and S. aureus in particular, alarms medical and public health practitioners.

duced complications due to reduced number of surgeries and shorter recovery times for the patient.

ue and accurate model system with the potential to study a broad range of clinically relevant issues in transfusion medicine, such as HDN, tr

ase, and monitor interventions in patients with COPD and other respiratory disorders. This will improve diagnosis and recognition of therap

new treatment option for patients with this particularly devastating disease.

opportunistic infections. The type of rapid assay being developed under this phase I proposal, if successful, could have a dramatic impact o

her bioactive compounds in biomedical research.

ures; development of advanced online commercial interface features; and an experimental test of the impact of the ESSP assessment and p

from using the host's cellular mechanism for its life cycle. Because host mechanisms essential to the virus are blocked, it will be difficult fo

stic tool to define those individuals for whom androgen therapy is not only indicated, but also effective and safe.
r degeneration (AMD). Since the final death pathway leading to AMD is the degeneration of photoreceptors or RPE cells in the retina, findin
nsive, and do not provide data on toxicity progression. The overall goal of this project is to develop, validate, and commercialize Acucela's p

s to treat severe chronic pancreatitis. Specifically, the goal is to achieve insulin independence following a single islet infusion instead of the

for patients with advanced disease. The innovative breast cancer therapy to be developed in this proposal will target a mechanism inheren

oroalkane (HFA), which does not harm the ozone layer; unfortunately, but not surprisingly, the prices for the new HFA inhalers are much hig

well as causing long-term impacts on cardiovascular, metabolic, endocrine, and mental functions. We propose to develop a novel DiscTread

aces and ultimately lower implant infection rates.

transmission, limited availability, and high procurement costs associated with allograft. Many synthetic alternatives have been developed,

nclude (1) Cuff-less Blood Pressure (2) Shock Meter (3) Laser Pulse Oximetry (a technique patented by Dr. David Goldfarb, an AFrame advise
nsequently healthier citizens.
ealth. Further, such as system will give health researchers the ability to perform continuous exposure studies over large population segmen

s are often used in sterile environments, many are FDA approved, and their cost (about 10% of peristaltic pumps), energy requirements, an

ion in the red region of the spectrum, high density and high effective atomic number, fast decay time with no afterglow, and orders of mag

priate delivery system has these benefits as a lead candidate in the search for novel alcoholism pharmacotherapies.

s breast ultrasound tool. The goal is to provide radiologists with a higher degree of confidence to differentiate many benign from more susp

(FOBT) and endoscopic colorectal examination (colonoscopy) but these methods are of limited effectiveness due to either their sensitivity
An important goal is to develop a cost- effective test to screen for mutations in the NF1 gene. Significant progress was made during Phase I
ents a highly innovative approach to the treatment of spinal cord injures, with significant clinical potential.

ct in billions of dollars. Xenograft islet transplantation represents an alternative therapeutic approach for Type 1 diabetes over classic alloge
etic peptide representing the CD8+ T cell epitope of E7 was effective in eradicating established tumors in a cervical cancer animal model. Th

and drug discovery.

nventorying precious liquids which will be convenient and affordable, will pay for itself through reduced labor costs, and will lead to improv
cal computational prediction models. We believe that such a knowledge base can facilitate research in the pharmaceutical and drug discove
will add a potent, efficacious, well-tolerated and economical antibacterial drug to a currently quite limited inventory of compounds with effi

e baby-boom generation reaches age 65, continuing for many years thereafter.

he existence and severity of brain injury, based on imaging techniques such as CT scanning or MRI, are expensive, not consistently reliable,

y CNS plasticity. The GEMINI tool will also enable GM assessment of infants in rural areas where access to specially- trained practitioners is

training system to assist in combating sarcopenia which is an age-related progressive loss of skeletal muscle that leads to a decline in musc
by providing more relevant information to those scientists trying to characterize these health problems, and also to the pharmaceutical res

fication (papHDA). Both Bst polymerase and T7 polymerase have been reported to function in HDA. In Phase I we propose to focus on deve
based on highly informative microsatellite markers suggest MDA amplifications with small quantities of input DNA can result in a loss of gen

to protect from the cellular, biochemical and molecular deleterious changes following hemorrhage or ischemia, but to date no significant i
could theoretically save more lives than any other measure; however, the best strategy to achieve this goal outside of the operating room a
phage display libraries and transcriptional reporter cell lines. We propose to validate and apply these tools for discovery peptide agonists an

major health problems worldwide and there is now a great deal of interest in developing an option for a potential cure by transplantation

tration of these GFAP-K5 nanoparticles (GFP-K5-NP) reduces the retinal vascular leakage and atenuates retinal NV in OIR rats. This project w

omy and physiology, and to study the mechanism of endothelial cells differentiation into a BBB phenotype. Considering these realistic prem
mes for both caregivers and their loved ones.
 rable morbidity and mortality.

inated air procured from gas companies, measure its sensitivity, and mass selectivity. During Phase II a person portable instrument will be

elation to biological function, and creating powerful tools for drug design and medicine research. Using innovative numerical methods, the

00,000 cases per year) or spinal cord injury (11,000 cases per year). Compared to the stand-alone NuStep device, the electrical stimulation c

tic resonance. If successful, this technology could serve as a powerful platform for the rational design of pharmaceuticals for the treatmen
ng term survival. CFFONE: A Cell Phone Support Program for Teens with Cystic Fibrosis, will make use of cutting-edge technology- a broadba
mily members affected by BPD.

re for families, local, state and federal agencies, and (iii) is pro-active in its outreach to minority groups such as the Hispanic population. OU

than an order of magnitude in many cases.

e treatment sooner and at a greater frequency. This will limit the spread of local wound infection, reduce the incidence of deep or systemic

enspace proposes to manufacture enough SLPI for a preclinical trial with a research partner and develop a production system to produce S
fusion medicine, such as HDN, transfusion reactions, and IVIg therapy.

gnosis and recognition of therapeutic benefits as well as lower the cost of the health care.

l, could have a dramatic impact on the ability to detect (and thereby enable appropriate treatment) opportunistic infections in the develop