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    Corneal dystrophies are a group of progressive, usually bilateral and genetically determined disorders that cause non-inflammatory opacification of the cornea. They are classified based on which layer of the cornea is affected: epithelial, Bowman's layer, stromal, or endothelial. Epithelial dystrophies present with dot-like opacities, epithelial microcysts, or whorled fingerprint-like lines and are caused by thickening of the basement membrane and deposits of fibrillary protein. Symptoms of corneal dystrophies include watery eyes, dry eyes, glare sensitivity, light sensitivity, eye pain, and feelings of something in the eye or corneal erosions.

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    Corneal dystrophies are a group of progressive, usually bilateral and genetically determined disorders that cause non-inflammatory opacification of the cornea. They are classified based on which layer of the cornea is affected: epithelial, Bowman's layer, stromal, or endothelial. Epithelial dystrophies present with dot-like opacities, epithelial microcysts, or whorled fingerprint-like lines and are caused by thickening of the basement membrane and deposits of fibrillary protein. Symptoms of corneal dystrophies include watery eyes, dry eyes, glare sensitivity, light sensitivity, eye pain, and feelings of something in the eye or corneal erosions.

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    8 views11 pages

    Cornea PDF

    Uploaded by

    Wen Ting
    Corneal dystrophies are a group of progressive, usually bilateral and genetically determined disorders that cause non-inflammatory opacification of the cornea. They are classified based on which layer of the cornea is affected: epithelial, Bowman's layer, stromal, or endothelial. Epithelial dystrophies present with dot-like opacities, epithelial microcysts, or whorled fingerprint-like lines and are caused by thickening of the basement membrane and deposits of fibrillary protein. Symptoms of corneal dystrophies include watery eyes, dry eyes, glare sensitivity, light sensitivity, eye pain, and feelings of something in the eye or corneal erosions.

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    of 11

    cornea dystrophy

    Corneal Dystrophies
    Group of progressive , usually bilateral , mostly
    genetically determined , non inflammatory opacifying
    disorders

    Classification

    Epithelial

    Bowman layer

    Stromal

    Endothelial
    Epithelial dystrophies

    Cogan epithelial basement membrane


    dystrophy

    Meesman epithelial dystrophy

    Lisch epithelial dystrophy


    Epithelial dystrophies

    Sporadic

    Histology

    Thick basement membrane

    Deposits of fibrillary protein

    Absence of hemidesmosomes
    Epithelial dystrophies
    Onset

    Signs

    Dot like opacities

    Epithelial microcyst

    Subepithelial map like pattern

    Whorled fingerprint – like lines


    Lisch epithelial dystrophy
    Inheritance

    AD or XLD

    Gene locus on Xp 22.3 in XLD

    Signs

    Grey band with whorls

    Densely packed microcysts


    Reis – Bucklers
    dystrophy
    Signs:

    Grey white , fine ,round and polygonal

    subepithelial opacities

    Treatment:

    Directed at recurrent errosions

    Excimer laser keratectomy


    Endothelial
    dystrophies
    Signs

    Corneal guttata

    Beaten metal appearance

    Stromal edema

    Epithelial edema

    Microcyst and bullae


    Symptoms of Corneal Dystrophies

    • Watery eyes
    • Dry eyes
    • Glare
    • Sensitivity to light
    • Pain in the eye
    • The feel of something in your eye
    • Corneal erosions
    Pathophysiology
    A corneal dystrophy can be caused by an
    accumulation of extraneous material in the
    cornea, including lipids and cholesterol crystals.
    Mooren’s Ulcer

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