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LOPERAMIDE

Loperamide is slightly soluble in water therefore at 1mg per 5mL the drug should be in solution.
Loperamide is stated to be stable at pH 2 - 9.1 The commercially available liquid contains ethanol and
parabens. The following formula is suggested:

Formula

Loperamide 1mg per 5mL

Loperamide capsules 2mg 10

Glycerol 40 mL
Parabens 0.1 %
Water to 100 mL

Expiry: 2 weeks (suggested).

Storage: Refrigerate.

Shake well before use

NOTE
1. A suspending agent is not necessary but it is advisable to shake the bottle in case there is any
undissolved drug.

REFERENCE
1. McEvoy GK, ed. AHFS Drug Information. Bethesda MD: American Society of Health-System Pharmacists, 2000:
2617.

Indomethacin is practically insoluble in water and sparingly soluble in alcohol.

For optimum stability an acidic pH of 4 - 5 is required together with the inclusion of co-solvents
such as ethanol and glycerol. Acidic suspensions without co-solvents are relatively
unstable. Indomethacin preparations are light sensitive. Indocin® oral suspension may contain
sodium hydroxide or hydrochloric acid to adjust the pH to 4 - 5.
 Formula 1

Indomethacin 2mg per mL

Indomethacin capsules 25mg 4

Ethanol 95% 10 mL
Parabens 0.1 %
Syrup to 50 mL

Ethanol is used to wet the powder. In the original study1 only 0.007% parabens
was used; this concentration is probably inadequate.

Expiry: 30 days.

Stability: reported to be chemically stable for at least six months but the assay
was not stability indicating.

Storage: Refrigerate. Protect from light.

SHAKE BEFORE USE

Other Formulations 2

A number of formulations prepared from Indomethacin powder were investigated including one
similar to that described above.

 2mg per mL
Indomethacin 200mg, raspberry syrup 20mL, glycerol to 100mL. This formulation was
difficult to re-disperse but showed excellent dose uniformity when dispersed. Chemically
stable for at least 30 days under refrigeration.
Suspensions prepared from capsules may have a different pH due to capsule
excipients. Check that the pH is the range 4 - 5.

Preservative and alcohol free preparation

If such a preparation is required for an infant, a simple dispersion of the capsule contents in a
mixture of 20% glycerol and sterile water is suggested. Prepare a fresh supply every 48 hours,
refrigerate, protect from light and ensure complete re-dispersion before administration.

REFERENCES
1. Das Gupta V., Gibbs C.W., Ghanekar A.G. Stability of pediatric liquid dosage forms of ethacrynic acid, indomethacin,
methyldopate hydrochloride, prednisone and spironolactone. Am J Hosp Pharm 1978; 35: 1382-85.
2. Stewart P.J., Doherty P.G., Bostock J.M., Petrie A.F. The stability of extemporaneously prepared paediatric formulations
of indomethacin. Aust J Hosp Pharm 1985; 15 (1): 55-60.

FOLIC ACID
Folic Acid is practically insoluble in water but the addition of sodium hydroxide forms soluble sodium
folate. Folic Acid injection has a pH of 8 - 11.
Oral solutions and a range of tablet strengths (most brands disperse rapidly) are available in some
countries.
The stability of a 1mg per mL folic acid solution for oral use has been briefly reported.1
The following recommendations are made on the basis of this study and from the formulation of the
injection.

Formula A

Folic Acid 1mg per mL

Folic Acid injection, 15mg per mL 4 mL

Parabens 0.1 %
*Sodium hydroxide solution 1M qs to pH 8
Water to 60 mL

*Addition usually unnecessary; only necessary if final pH < 8

Expiry: 30 days

Storage: Refrigerate. Protect from light.

Formula B

Folic Acid 1mg per mL

Folic acid tablets 5mg 10

Sodium hydroxide solution 1M qs to pH 8
Parabens 0.1 %
Water to 50 mL

Expiry: 30 days

Storage: Refrigerate. Protect from light.

NOTES
1. Parabens are suggested on the basis that sodium propyl hydroxybenzoate was used in the
study cited.
2. For a preservative free preparation omit the parabens and assign an expiry date of 7 days.
3. If sodium hydroxide is not used, folic acid may be in suspension and mixtures should be shaken
prior to administration.

REFERENCE
1. Smith S.G. A folic acid solution for oral use. Pharm J 1976; February 7: 108
 Allopurinol
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to Formulation Index Page

A New Zealand standardised formulation is available Formula and Batch Sheet

This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1, and has been approved by
the Extemporaneous Compounding Pharmacists' Group.
Alternatives are given below.

Allopurinol is very slightly soluble in water and alcohol. The aqueous solubility is increased at
alkaline pH but all published investigations have been performed on suspensions at acidic pH.

A 20mg per mL suspension, prepared from allopurinol tablets and a base consisting of one third
methylcellulose solution 9% and two thirds of cherry flavored syrup, is reportedly chemically
stable for at least 14 days at room temperature and under refrigeration.1

Allopurinol 20mg per mL prepared from tablets in a vehicle of Ora-Sweet and Ora-plus 1:1
or Ora-Sweet SF and Ora-Plus 1:1 or cherry syrup is chemically stable for 60 days at 5 or 25°C
protected from light.2 The final pH of these preparations was in the range 3.2 - 4.3. Microbial
testing was not performed.

If possible allopurinol suspension should be made in accordance with the directions of the
published studies1,2 but if commercial suspending vehicles are not available the following is
suggested based on evaluation of the literature.

Formula

Allopurinol Suspension

Allopurinol tablets qs
* Methylcellulose 1% 50 mL
Citric acid 250 mg
Syrup 20 mL
Water to 100 mL

*Use either 50 mL of a 1% solution or 0.5g per 100mL. If the final

product is too viscous reduce the amount of methylcellulose.

Expiry: 30 days.

Storage: Refrigerate. Protect from light.

Shake well before use

REFERENCES
1. Dressman J.B., Poust R.I. Stability of allopurinol and five antineoplastics in suspension. Am J Hosp
Pharm 1983; 40: 616-8. [PubMed]
 2. Allen LV, Erickson MA. Stability of acetazolamide, allopurinol, azathioprine, clonazepam, and flucytosine in
extemporaneously compounded oral liquids.
Am J Health-Syst Pharm 1996; 53: 1944-9.[PubMed]

Allopurinol
This information is provided by Pharminfotech Please read disclaimer before using this information Back
to Formulation Index Page

A New Zealand standardised formulation is available Formula and Batch Sheet

This formula uses Ora-Blend/SF or Ora-Plus and Ora-Sweet/SF; 1:1, and has been approved by
the Extemporaneous Compounding Pharmacists' Group.
Alternatives are given below.

Allopurinol is very slightly soluble in water and alcohol. The aqueous solubility is increased at
alkaline pH but all published investigations have been performed on suspensions at acidic pH.

A 20mg per mL suspension, prepared from allopurinol tablets and a base consisting of one third
methylcellulose solution 9% and two thirds of cherry flavored syrup, is reportedly chemically
stable for at least 14 days at room temperature and under refrigeration.1

Allopurinol 20mg per mL prepared from tablets in a vehicle of Ora-Sweet and Ora-plus 1:1
or Ora-Sweet SF and Ora-Plus 1:1 or cherry syrup is chemically stable for 60 days at 5 or 25°C
protected from light.2 The final pH of these preparations was in the range 3.2 - 4.3. Microbial
testing was not performed.

If possible allopurinol suspension should be made in accordance with the directions of the
published studies1,2 but if commercial suspending vehicles are not available the following is
suggested based on evaluation of the literature.

Formula

Allopurinol Suspension

Allopurinol tablets qs
* Methylcellulose 1% 50 mL
Citric acid 250 mg
Syrup 20 mL
Water to 100 mL

*Use either 50 mL of a 1% solution or 0.5g per 100mL. If the final

product is too viscous reduce the amount of methylcellulose.

Expiry: 30 days.

Storage: Refrigerate. Protect from light.

Shake well before use

REFERENCES
 1. Dressman J.B., Poust R.I. Stability of allopurinol and five antineoplastics in suspension. Am J Hosp
Pharm 1983; 40: 616-8. [PubMed]
2. Allen LV, Erickson MA. Stability of acetazolamide, allopurinol, azathioprine, clonazepam, and flucytosine in
extemporaneously compounded oral liquids.
Am J Health-Syst Pharm 1996; 53: 1944-9.[PubMed]

CIPROFLOXACIN

Ciprofloxacin is practically insoluble in water and ethanol. It has a bitter taste.

The commercially available ciprofloxacin suspension should be used whenever possible, as it is
formulated to mask the bitter taste of the drug. Tablets are available in a variety of sizes and they usually
disperse readily in water.

Formula 1

Ciprofloxacin Suspension 50mg per mL

Ciprofloxacin tablets 750mg 4

Ora-Plus 30 mL
Syrup 30 mL

Premix the Ora-Plus and syrup and wet the powdered tablets with a small
amount of the mixture to form a paste. Gradually add the rest of the vehicle
and make to volume.

Expiry: 30 days

Stability: Chemically stable for 56 days.

Storage: Refrigeration or 24 - 26°C.

Shake well before use

NOTES
1. The final pH of this preparation is about 4.5.
2. The suspension is bitter with a prolonged aftertaste. Palatability can be improved by mixing with
chocolate syrup just prior to giving the dose.
3. The oral bioavailability of ciprofloxacin from this formulation has not been assessed.
4. If Ora-Plus is not available a simple base consisting of a 1:1 mixture of methylcellulose 1% and
syrup, preserved with parabens is suggested.
5. There are anecdotal reports that some extemporaneously prepared ciprofloxacin suspensions have
poor physical characteristics, e.g. flocculation and solidification. Physical characteristics should be
observed. The commercially available oral liquid or a tablet dispersion should be used whenever
possible.

REFERENCE
 1. Johnson CE, Wong DV, Hoppe HL, Bhatt-Mehta V. Stability of ciprofloxacin in an extemporaneous oral liquid
dosage form. Int J Pharm Comp 1998: 2 (4): 314-317.

DIAZEPAM

Diazepam has a solubility in water of 0.05mg per mL; 41mg per mL in 95% ethanol and 17mg per mL in
propylene glycol. In aqueous solution diazepam is relatively stable at pH 4 - 8 with maximum stability at
about pH 5.1,2 Stability and solubility is increased in mixed solvent systems of water, ethanol and
propylene glycol.

Newton et al3 reported that a diazepam oral liquid prepared from tablets in a syrup base with 30%
propylene glycol and 5% ethanol was stable for at least 14 days at room temperature in amber glass
bottles. The amount of propylene glycol in this formulation may be unacceptable. In the same study, a
1mg per mL suspension compounded from tablets and unpreserved Syrup USP, was reported to be
chemically stable, but dose uniformity may be erratic as the preparation is a solution/suspension of
diazepam.

Strom4 studied the stability of a diazepam oral liquid prepared from tablets containing 3.6% v/v of ethanol
95% and 5% v/v of propylene glycol in a syrup base with 1% sodium carboxymethylcellulose and 2%
magnesium aluminium silicate. The pH was adjusted to 4.2 with hydrochloric acid. The preparation was
stable for 60 days at room temperature or under refrigeration.

Most tablet brands disperse rapidly and this option should be considered before making an oral liquid.

The following formulation is based on published studies and stability data.

Formula

Diazepam Oral Liquid

Diazepam tablets qs
Ethanol 95% 5 mL
Methylcellulose 1g
Parabens 0.1 %
Glycerol 20 mL
Water to 100 mL

Expiry: 30 days.

Storage: Refrigerate

Shake well before use

NOTE
1. Most of the diazepam may be in solution but this has not been validated. A suspending agent has
been included in case some of the drug is in suspension.
REFERENCES
1. Dobrinska MR In: Connors KA, Amidon GL, Stella VJ. Chemical stability of Pharmaceuticals. New York: John
Wiley, 1986: 412-20.
2. Trissel LA. Stability of Compounded Formulations. Washington DC: American Pharmaceutical Association, 1996.
3. Newton DW, Schulman SG, Becker CH. Limitations of compounding diazepam suspensions from tablets.
Am J Hosp Pharm 1976; 33: 450-2.
4. Strom JG, Agbai KU. Formulation and stability of diazepam suspension compounded from tablets.
Am J Hosp Pharm 1986; 43: 1489-91.

NORFLOXACIN

Norfloxacin is very slightly soluble in water and alcohol. The drug is relatively insoluble in water at
neutral pH but solubility increases in acidic and basic conditions. Norfloxacin eye drops are formulated as
a solution at a pH of about 5.2.

The preparation of norfloxacin suspension from tablets is not recommended unless a full assessment of
physical stability can be performed. Boonme et al determined that the physical properties of norfloxacin
suspensions are influenced by the brand of tablet used.1

Tablet dispersion in plain water is the best option. The method for the Noroxin® brand of norfloxacin is as
follows:
 Break the scored tablet and add to 10 - 15mL of water in a wide bottomed glass or cup.
 Leave for 10 - 15 minutes, swirling occasionally. A coarse chalky suspension is formed.
 The mixture has a slight bitter aftertaste and can be mixed with fruit cordial or chocolate milk prior
to administering the dose.
 Tablet dispersions should be used immediately.

NB This method is not suitable for doses smaller than a measurable tablet fraction as the drug
is not in solution.

Formula 1

Norfloxacin Suspension 20mg per mL

Norfloxacin tablets 400mg 5

Water 15 mL
*Vehicle to 100 mL

Expiry: 30 days.

Storage: Room temperature. Protect from light (amber glass containers used
in the study).

Shake well before use

NOTES
 1. *Formula for the vehicle:

Tragacanth 1g
Saccharin sodium 1g
Sorbitol solution 100 mL
Glycerol 100 mL
Parabens 0.1 %
Peppermint spirit BP 30 mL
Water 300 mL
Syrup BP to 1000 mL
2.
3. The brands of norfloxacin tablets used in the study were not described. Some brands may produce
a dispersible and pourable product, but others produce a liquid that is gel like and too viscous to
pour. This is likely to be due to a physical interaction between tablet excipients and components of
the base.1
4. Other vehicles could be investigated, for example a simple mixture of syrup and glycerin. Physical
stability should be evaluated.

REFERENCE
1. Boonme P, Phadoongsombut N, Phoomborplub P, Viriyasom S. Stability of extemporaneous norfloxacin
suspension. Drug Dev Ind Pharm 2000; 26 (7): 777-9.

ONDANSETRON

Ondansetron hydrochloride dissolves in water and the pH of solutions is about 4.5 - 4.6. A precipitate of
free base develops if the pH is increased to 5.7 and above.1 The injection has a pH of 3.3 - 4.0.
Several stability studies have been performed on oral liquids prepared from crushed tablets or diluted
injection. In most cases, only a few doses of ondansetron are required with each course of treatment and
tablet dispersion is a convenient option.

Tablet dispersion:
To disperse the tablet place in 10 - 15mL of water in a wide bottomed cup or glass. Do not use a conical
measure as the tablet tends to aggregate at the base. Leave the tablet to disintegrate for about 10 minutes,
swirling occasionally. Eventually a cloudy suspension is formed which can be mixed with a flavoured
cordial. The mixture has a slight bitter aftertaste but is not too unpleasant to take without flavouring.

Formula A2

Ondansetron 4mg per 5mL

Ondansetron tablets 8mg 10

*Vehicle as below to 100 mL

* Cherry Syrup USP, Syrpalta, Ora Sweet or Ora Sweet SF.

Expiry: 30 days.

Stability: 6 weeks at 4°C.

 Storage: Refrigerate. Amber plastic bottles used in the study.

Shake well before use

Formula B3

Ondansetron 4mg per 5mL

Ondansetron tablets 4mg 20

*Sodium Benzoate 0.2 %
Raspberry syrup BP to 100 mL

*Alternatively, use parabens 0.1%

Expiry/Stability: 14 days.

Storage: 2 - 30°C.

Shake well before use

NOTES
1. Manufacturer reports that plain Syrup BP causes gross
flocculation. This is probably a pH effect causing precipitation of
ondansetron. Any syrup based vehicle can be used but to avoid
precipitation ensure the pH is below about 4.5 by addition of citric
acid. N.B. precipitation may be difficult to detect due to presence of
tablet excipients.
2. Parabens 0.1% could be substituted for sodium benzoate.
3. Raspberry Syrup BP is made as follows:

Concentrated raspberry juice 1 part

Syrup 11 parts
4. This should be freshly prepared.

Oral administration of the injection

Graham et al4 reported the stability of ondansetron hydrochloride oral liquids prepared by diluting the
injection. Solutions of approximately 0.27mg per mL and 0.07mg per mL in orange juice and cola were
stable for at least 1 hour. A solution of approximately 0.5mg per mL was stable for 7 days in cherry syrup
(pH 3.4).

REFERENCES
1. Leak RE, Woodford JD. Pharmaceutical development of ondansetron injection. Eur J Cancer Clin
Oncol 1989; 25 (suppl 1): S67-S69.
 2. Williams CL, Sanders PL, Laizure SC, Stevens RC, Fox JL, Hak LF. Stability of ondansetron hydrochloride in syrups
compounded from tablets. Am J Hosp Pharm 1994; 51: 806-8.
3. Provided by the manufacturer of Zofran®.
4. Graham CL, Dukes GE, Fox JL, Kao CF, Hak LJ. Stability of ondansetron hydrochloride injection in
extemporaneously prepared oral solutions. Am J Hosp Pharm 1993; 50: 106-8.

RANITIDINE

The solubility of ranitidine hydrochloride in water is about 660mg per mL. An oral solution of ranitidine
hydrochloride is available in most countries, it contains ethanol 7.5% and parabens. The injection has a
pH of 6.7 - 7.3 and most formulations contain 0.5% phenol.
Commercially manufactured preparations are available in most countries and should be used if possible.

Formula 1

Ranitidine 15mg per mL

Ranitidine tablets 150mg 10

Water 50 mL
Syrup to 100 mL

Expiry: 7 days

Storage: Refrigerate. Protect from light.

(The storage conditions were not mentioned in the study.)

Shake well before use

REFERENCE
1. Karnes T.H., Harris S.R., Garnett W.R., March C. Concentration uniformity of extemporaneously prepared ranitidine
suspension. Am J Hosp Pharm 1989; 304-7.

Vancomycin Oral Solution

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to Formulation Index Page
 The following formula has been recommended by the Compounding Pharmacists' Working Group

Vancomycin 50 mg in 1 mL oral solution

Vancomycin 500 mg injection; 10 vials

Glycerol BP 40 mL
Water for Irrigation to 100 mL

Expiry date; 14 days from preparation; refrigerated

Method
Measure the glycerol into the final measuring cylinder.
Draw up 50 mL of water for irrigation into a 50 mL syringe and reconstitute each vancomycin vial
with approximately 5 mL of water for irrigation using a 50 mL syringe and needle.
Draw up the contents of each vial (ensuring vials are completely empty) and transfer into the
measuring cylinder with the glycerol and mix well.
Make up to volume with water.
Source of Formula:
International Journal of Pharmaceutical Compounding. January/February 2003; Volume 7, Number 1, page 64.
Sweetman SC, editor. Martindale: the complete drug reference. 35th edition. London: Pharmaceutical Press; 2006;
page 320.

Sildenafil Citrate 2.5 mg/mL Oral Liquid

Loyd V. Allen, Jr., PhD
Professor Emeritus
College of Pharmacy, University of Oklahoma
Oklahoma City

US Pharm. 2018;43(2):47-48.

Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared.
Accurately weigh or measure each ingredient. Mix 50 mL of Ora-Plus with 50 mL of Ora-Sweet for
use as the vehicle in this preparation. Obtain the required number of sildenafil citrate tablets or the
required quantity of powder and place in a mortar. Pulverize the tablets, if used, to a fine powder.
Add a small quantity of the Ora-Plus:Ora-Sweet mixture and mix to a smooth paste. Geometrically,
add the remainder of the Ora-Plus:Ora-Sweet mixture to final volume and mix well. Package and
label.

Use: Sildenafil citrate oral liquid has been used to treat pediatric pulmonary arterial hypertension in
children in whom the risk-benefit profile of sildenafil is deemed acceptable.

Packaging: Package in tight, light-resistant containers.1

Labeling: Keep out of reach of children. Shake well. Discard after ____ [time period].
Stability: A beyond-use date of up to 91 days may be used for this preparation. 1-4

Quality Control: Quality-control assessment can include weight/volume, pH, specific gravity, active
drug assay, color, rheologic properties/pourability, physical observation, and physical stability
(discoloration, foreign materials, gas formation, mold growth).5

Discussion: A number of stability studies have been conducted on oral liquid formulations of
sildenafil for pediatric use. From these, it appears that sildenafil is relatively stable in vehicles, with
an acidic pH around 4 to 5. Sildenafil for oral suspension at 10 mg/mL (Revatio) is commercially
available with a beyond-use date of 60 days after reconstitution.

One study involved compounded sildenafil citrate in a citrate-buffered solution (0.1 M, pH 4) and
either a syrup excipient (resulting in a suspension) or a sugar-free syrup excipient (resulting in a
solution); both had pH values of approximately 4.2. Both the suspension and the solution were
slightly pink and fruit-flavored. The suspension demonstrated stability for 91 days at both 4°C and
25°C; however, the solution was stable only for 30 days, possibly related to a nonredispersible
sediment at the bottom of the container.3

A study by Nahata and colleagues that involved sildenafil citrate tablets (Revatio 20 mg) with a
mixture of 1:1 Ora-Sweet and Ora-Plus at 2.5 mg/mL and pH 4.5-4.7 demonstrated stability of 91
days at both 4°C and 25°C. Also studied was a mixture of 1:7 (1% methyl cellulose:simple syrup)
at pH 5.1 to 4.9 that also demonstrated stability of 91 days at both 4°C and 25°C. 4

Sildenafil citrate (C22H30N6O4S.C6H8O7, MW 666.70) occurs as a white to off-white, crystalline

powder that is soluble 3.5 mg/mL in water. It is formulated as tablets equivalent to 25 mg, 50 mg,
and 100 mg of sildenafil for oral administration. The tablets also contain microcrystalline cellulose,
anhydrous dibasic calcium phosphate, croscarmellose sodium, magnesium stearate,
hydroxypropyl methylcellulose, titanium dioxide, lactose, triacetin, and FD&C Blue #2 Aluminum
Lake.6,7

Ora-Plus is an oral suspending vehicle that accepts dilution of up to 50% or more with water,
flavoring agents, or syrups while still retaining its suspending properties. It has a pH of
approximately 4.2 and an osmolality of about 230 mOsm/kg. It is a thixotropic vehicle with a
viscosity of approximately 1,000 cps at 25°C. Ora-Plus contains purified water, microcrystalline
cellulose, sodium carboxymethyl cellulose, xanthan gum, carrageenan, sodium phosphate, and
citric acid as buffering agents; simethicone as an antifoaming agent; and potassium sorbate and
methylparaben as preservatives.8

Ora-Sweet syrup vehicle is a flavoring vehicle for oral extemporaneous preparations. It is flavored
with a citrus-berry flavor blend and contains glycerin and sorbitol to prevent cap lock, a problem
associated with many syrups. It is buffered to a pH of approximately 4.2 and it has an osmolality of
about 3,240 mOsm/kg. It contains purified water, sucrose, glycerin, sorbitol (5%), flavoring, sodium
phosphate, and citric acid as buffering agents, and potassium sorbate and methylparaben as
preservatives.9

REFERENCES

1. U.S. Pharmacopeia/National Formulary [current revision]. Rockville, MD: U.S. Pharmacopeial

Convention, Inc; January 2018.
2. Nahata MC, Morosco RS, Brady MT. Extemporaneous sildenafil citrate oral suspensions for the
treatment of pulmonary hypertension in children. Am J Health Syst Pharm. 2006;63:254-257.
3. Provenza N, Calpena AC, Mallandrich M, et al. Design and physicochemical stability studies of
paediatric oral formulations of sildenafil. Int J Pharm. 2014;460:234-239.
4. Nahata MC. Extended stability of morphine and sildenafil for oral use in infants and young
children. IJPC. 2016;20:247-249.
5. Allen LV Jr. Standard operating procedure for performing physical quality assessment of oral
and topical liquids. IJPC. 1999;3:146-147.
6. McEvoy GK, ed. AHFS Drug Information 2016. Bethesda, MD: American Society of Health-
System Pharmacists; 2016:1918-1932.
7. Physicians’ Desk Reference. 70th ed. Montvale, NJ: PDR Network; 2016:1929-1936.
8. Ora-Plus product information. Allegan, MI: Perrigo; 2018.
9. Ora-Sweet product information. Allegan, MI: Perrigo; 2018.

Sildenafil 5-mg/mL Pediatric Suspension; Viagra

Components: Sildenafil Citrate
Carboxymethylcellulose Sodium
Stevioside (Stevia)
Flavor, for bitter drugs
Acesulfame Potassium
Flavor
Water, Preserved (Parabens)