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A Beta Lactam
A Beta Lactam
a) Penicillin inhibition
b) Penicillin backbone
c) Cephalosporin backbone
The (2) amide bond in antibacterial is more the strain than amide bond in than its natural substrate very unstable bond PBP mistakenly attack here
Inhibits resonance of the lactam nitrogen with its b-lactamase (b-lactamase acylase / penicillinase) are
carbonyl group (the lone pair IS NOT enzymes produced by penicillin resistant bacterias
DELOCALIZED into carbonyl)
b-lactam become MORE REACTIVE and thus MORE Catalyze the hydrolysis of the b-lactam amide bond
SENSITIVE to nucleophilic attack compared to normal (ring opening) and inactivate b-lactam antibiotics to
planar amides
penicillioic acids before they can reach the PBPs
This happens because of a highly strain bond energy of the
amide bond