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Longevity Secrets of The Naked Mole Rat
Longevity Secrets of The Naked Mole Rat
Longevity Secrets of The Naked Mole Rat
Secrets
of the
• Is menopause inevitable?
• Paraquat
• High temperature
• Heavy metals
• DNA damaging agents
• Harmful foreign materials
Interestingly, in 2016, a report was published claiming that two naked mole rats developed
cancer. However, as it turns out, both naked mole rats in this case were born and living in
captivity at zoos, which is a much different environment then their subterranean burrows.
• Rats typically live only 2 to 2.5 • The naked mole rat is the longest-living
years maximum. rodent known.
• And yet the longest lived naked • The exceptional longevity and disease
mole rat ever observed was 32 resistance of the naked mole rat have
years old. researchers calling it “a true ‘supermodel’ for
aging research and resistance to chronic
• That’s a 16x increase in lifespan. age-associated diseases.”
(Edrey YH. et al, 2011)
7
Naked Mole Rats Don’t Age
• Unlike all other mammals studied to date, a
naked mole rat’s risk of death does no go up as
it gets older, wrote scientists in a study from
January 2018.
• “After they reached sexual maturity at 6 months of age, each naked mole rat’s daily chance of
dying was a little more than one in 10,000. It stayed the same the rest of their lives and even
went down a little,” reported scientist Buffenstein.
• However, ultimately, in even the most recent studies, they admit that they haven’t
figured it out yet; to the mainstream, the longevity secrets of the naked mole rat remain
a mystery.
A friend of mine and fellow researcher emailed one of the reknowned scientists working with naked
mole rats asking them to study the metabolism of naked mole rats.
“No way in hell I am going to check metabolism. I got 3 grants from NIH [The
National Institutes of Health] decoding the naked mole rat genome so I have
no time for this metabolic nonsense.”
Mainstream medicine is not interested in metabolic research, because it would lead to cures for
diseases. By focusing (and funding) studies solely on genetics, the answers, like the explanations for
the outstanding features of the naked mole rat, are never found.
In the 2016 study that documented cancer in two naked mole rats living at the zoo, they
lived in an environment with 21% atmospheric oxygen compared to their natural 7%, and
CO2 was 0.04% compared to their natural 6%.
Similar Effects to Elevation
At Elevation Inside the Body
CO2 = 0.04%
O2 = 20.95% (Reduced pressure)
CO2 O2
O2 = 7% (Reduced concentration)
CO2 O2
Highly Saturated Tissue
Phospholipids
The Key to Maximum Longevity Cell Membranes of Naked Mole Rats
Hypothesis:
They hypothesized that the environment
would have a negative impact on the
activity, memory and social interaction of
the rats.
Results:
When the rats were put into an
environment of decreased oxygen
(“hypoxic”) and increased carbon dioxide
(“hypercapnic”)…
They became more social
Conclusion:
“Results did not support the original hypothesis that activity, memory and social interaction
levels would decrease under hypercapnic hypoxia.”
(Berkovits R. et al, 2017)
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References
• Edrey YH, park TJ, kang H, biney A, buffenstein R. Endocrine function and neurobiology of the longest-living rodent, the naked mole-rat.
Exp gerontol. 2011;46(2-3):116-23.
• Smith ES, omerbašić D, lechner SG, anirudhan G, lapatsina L, lewin GR. The molecular basis of acid insensitivity in the african naked
mole-rat. Science. 2011;334(6062):1557-60.
• Larson J, park TJ. Extreme hypoxia tolerance of naked mole-rat brain. Neuroreport. 2009;20(18):1634-7.
• Liang S, mele J, wu Y, buffenstein R, hornsby PJ. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked
mole-rat (heterocephalus glaber). Aging cell. 2010;9(4):626-35.
• Buffenstein R. The naked mole-rat: a new long-living model for human aging research. J gerontol A biol sci med sci. 2005;60(11):1369-77.
• O'connor tp, lee a, jarvis ju, buffenstein r. Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition
and gastrointestinal function. Comp biochem physiol, part A mol integr physiol. 2002;133(3):835-42.
• Csiszar A, labinskyy N, orosz Z, xiangmin Z, buffenstein R, ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J
physiol heart circ physiol. 2007;293(2):h919-27.
• Orr ME, Garbarino VR, Salinas A, Buffenstein R. Extended postnatal brain development in the longest-lived rodent: prolonged maintenance
of neotenous traits in the naked mole-rat brain. Front Neurosci. 2016;10:504.
• Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived
rodents. Nat Rev Genet. 2014;15:531–540.
• Delaney MA, Ward JM, Walsh TF, Chinnadurai SK, Kerns K, Kinsel MJ, Treuting PM (May 2016). "Initial Case Reports of Cancer in Naked
Mole-rats (Heterocephalus glaber)". Veterinary Pathology. 53 (3): 691–6.
• Ruby JG, Smith M, Buffenstein R. Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age. Elife. 2018;7.
• Lewis KN, mele J, hornsby PJ, buffenstein R. Stress resistance in the naked mole-rat: the bare essentials - a mini-review. Gerontology.
2012;58(5):453-62.
• Kim eb, fang x, fushan aa, et al. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature.
2011;479(7372):223-7.
• Lewis kn, andziak b, yang t, buffenstein r. The naked mole-rat response to oxidative stress: just deal with it. Antioxid redox signal.
2013;19(12):1388-99.
• Shams I, avivi A, nevo E. Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-
hypercapnic stresses. Comp biochem physiol, part A mol integr physiol. 2005;142(3):376-82.
• Berkovits R, boffa N, deluca V. The effects of hypercapnic hypoxia on naked mole rat activity levels, memory, and social interaction. 2010.
Available: https://macaulay.Cuny.Edu/eportfolios/newyorkcityonthebrain/files/2010/12/nmr-poster.Pdf [february 15, 2017].
• Barja G. Free radicals and aging. Trends Neurosci. 2004;27(10):595-600.
• Mitchell TW, Buffenstein R, Hulbert AJ. Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat
(Heterocephalus glaber): a comparative study using shotgun lipidomics. Exp Gerontol. 2007;42(11):1053-62.
• Hulbert AJ, Faulks SC, Buffenstein R. Oxidation-resistant membrane phospholipids can explain longevity differences among the longest-
living rodents and similarly-sized mice. J Gerontol A Biol Sci Med Sci. 2006;61(10):1009-18.