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Devia Afiani I1021161010
Devia Afiani I1021161010
Nim : I1021161010
1.
a = 4,537
b = -0,5576 = k
c = -0,99954
0,693
a. T1/2 = 𝑘
0,693
T1/2 = 0,5576
T1/2 = 1,2428 jam
𝑙𝑛𝑐2−𝑙𝑛𝑐1
b. K= 𝑡2−𝑡1
ln 30−ln 54
K= 2,0−1,0
3,4011−3,98898
K= 1,0
−0,5576
K= = -0,5576
1,0
c. Ct = C0 . e-kt
68 = C0 . e-0,5576 . 0,5
68
C0 = 0,75669
C0 = 89,865 µg/ml
d. Vd = Div
𝐶𝑜
250.000 µg
Vd = 89,865 µ𝑔/𝑚𝑙
Vd = 2781,95 ml = 2,781 L
e. C75 = C0 . e-kt
C75 = 89,865 . e-kt
C75 = 89,865 . e-0,557 . 75
C75 = 89,865 . e-41,775
C75 = 89,865 . 7,2 x 10-19
C75 = 6,4705 X 10-17 µg/mL
Dosis
C0 = 𝑉𝑑
175 mg
C0 = 2781,95 mL
C0 = 0,062905 mg/mL
C0 = 62, 905 µg/mL
Cp = C0 . e-kt
C75 = 62,905 . e-0,557 . 1,25
C75 = 62,905 . e-0,6962
C75 = 31,356 µg/mL
Dosis
f. C0 = Vd
275000
C0 = 2781,95
C0 = 98,851 µg/mL
Cp = C0 . e-kt
20 = 98,851 . e-0,5576 . t
0,2023 = e-0,5576 . t
-1,598 = -0,5576 . t
t = 2,865 jam
2.
0,693
a. Dosis 50 mg : t½ = 𝑘
0,693
= 1,012
= 0.6847 jam
0,693
Dosis 100 mg : t½ = 𝑘
0,693
= 1,118= 0,6198 jam
0,5
𝑙𝑛0,3
b. Dosis 50 mg : k = 2−1,5
ln 1,666
= 2,0−1,5
0,5104
= 0,5
= 1,0208 jam-1
1,4
𝑙𝑛0,8
Dosis 100 mg : k = 1,5−1
0.559
= 0,5
= 1,118 jam-1
c. Dosis 50 mg : Cp = C0 . e –kt
2 = C0 . e –1,0208 . 025
2 = C0 . 0,775
2
C0 = 0,775
= 2.58 µg mL-1
2,6 = C0 . 0,5539
2,6
C0 = 0,5539
C0 = 4,693 µg mL-1
𝐷𝑜𝑠𝑖𝑠
d. Dosis 50 mg : V = (𝐶𝑝)₀
50 𝑚𝑔
V = 2,58 µg mL−1 = 19,37 𝐿
𝐷𝑜𝑠𝑖𝑠
Dosis 100 mg : V = (𝐶𝑝)₀
100 𝑚𝑔
V = 4,693 µg mL−1 = 21,308 𝐿
e.
t = 2,5 jam
Dit : C0 ?
Cp = C0 . e –k.t
C0 = 275,3 mg