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Revista Română de Anatomie funcţională şi clinică, macro- şi microscopică şi de Antropologie

Vol. XVI – Nr. 1 – 2017 CLINICAL ANATOMY

FORENSIC SIGNIFICANCE OF LESIONS INDUCED


BY CARDIOPULMONARY RESUSCITATION

Sofia David1,2, Carleta Teodorescu2, L. Teodorescu2, R. Dospinescu2,


A. Knieling1,2, Diana Bulgaru-Iliescu1,2
1. University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania
Discipline of Forensic Medicine
2. Institute of Forensic Medicine, Iasi, Romania

FORENSIC SIGNIFICANCE OF LESIONS INDUCED BY CARDIOPULMONARY RESUSCI-


TATION (Abstract): Cardiopulmonary resuscitation (CPR) is a lifesaving emergency procedure
generating various injuries. At necropsy examination, lesions produced by CPR maneuvers are
regularly encountered, unrelated to the primary death cause. The aim of the current study is to
examine traumatic injuries observed at forensic necropsy after CPR and to make the differential
diagnosis with those induced by violent acts or accidents. The authors performed a retrospective
study at the Institute of Forensic Medicine from Iasi, Romania on 49 cases (32 males, 17 females)
that benefited from CPR manoeuvres prior to death. Mean age was 47.3 years, 24 cases (48.98%)
presented cardiac arrest secondary to trauma and 41 (83.67%) in an extra-hospital environment.
CPR duration reported in 21 cases (42.86%) registered a mean value of 42 minutes. Additional
gestures like vein puncture were reported in 25 cases (51.02%) and surgical interventions in 5
cases (10.20%). All intra-thoracic structures can be injured directly or indirectly by chest compres-
sions. Rib fractures are among the most common complications associated with CPR and found
in one third of cases. Petechiae on the surface of the heart are observed mostly on the posterior
surface. Perivascular haemorrhagic infiltrations can also be noticed and are poorly described in
the literature. Intra-abdominal organs are less often the site of complications secondary to resus-
citation. In conclusion, injuries produced during CPR may be responsible for important artefacts
impeding the understanding of traumatic lesions observed during necropsy and related to the
primary death cause. A thorough knowledge of possible aspects is mandatory to the differential
diagnosis with other traumatic lesions. Keywords: CARDIOPULMONARY RESUSCITATION,
FORENSIC NECROPSY, TRAUMATIC LESIONS, DIFFERENTIAL DIAGNOSIS

INTRODUCTION pecially if technical errors are committed. Nec-


Cardiac arrest is an extreme medical emer- ropsy is still considered the gold standard for
gency, leading to irreversible brain damage and study of CPR associated lesions despite exten-
death if proper measures to restore ventilation sive usage of medical imaging techniques (com-
and blood flow are not taken. Cardiopulmonary puted tomography, radiography) in the western
resuscitation (CPR) is fundamental for increas- world.
ing the survival chance of these patients. In the At necropsy examination, CPR-related inju-
last decade, the interest of forensic pathologists ries are commonly encountered, unrelated to
in the study of injuries caused by CPR has the primary death cause, and may mislead the
augmented due to the emergence of resuscita- forensic examination. One of the objectives of
tion guidelines containing specific recommen- the recommendations made by the European
dations concerning the depth of chest compres- Resuscitation Council is to establish an appro-
sions, CPR duration, sequence of maneuvers. priate balance between the benefit of CPR ma-
Even if it is a lifesaving procedure, CPR is an noeuvres and the risk of causing harm to the
aggressive method causing various lesions es- patient (1). An observational study published

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Forensic Significance of Lesions Induced by Cardiopulmonary Resuscitation

in 2013 found a higher incidence of iatrogenic a lesion mapping together with medical file
injuries provoked by manual CPR in patients details would allow forensic pathologists to
who received chest compressions at a compres- avoid artifacts and misinterpretations. Thus, it
sion depth greater than 6 cm (2). CPR injuries would be easier not to confuse them with inju-
may account for up to 20% of all injuries iden- ries induced by other factors such as acts of
tified at forensic necropsy (3). Forensic pa- willful or involuntary violence with completely
thologists have to be able to make the differen- different legal implications. Initial errors of
tial diagnosis between injuries associated to interpretation are not uncommon. Prahlow and
CPR and those generated by other traumas McClain presented the case of an individual
related to violent acts, accidents, suicide or presenting a circular wound of 9 mm that was
homicide (4,5). suspected to be the entrance point of a gunshot
Although CPR can cause secondary life- but was finally found to be secondary to place-
threatening lesions, such situations are extreme- ment of a thoracic drain (11).
ly rare (3). Hemopericardium, hemothorax, The aim of the current study is to examine
hemoperitoneum or other lesions produced dur- traumatic injuries observed at forensic necrop-
ing CPR may be responsible for important ar- sy after CPR and to make the differential diag-
tefacts impeding the understanding the trauma nosis with those induced by violent acts or
observed during necropsy (6). In such situa- accidents.
tions, it is sometimes difficult for the forensic
pathologist to determine the exact cause of MATERIAL AND METHODS
death, particularly in cases where no other pa- The authors performed a retrospective study
thology has been identified. It is therefore im- at the Institute of Forensic Medicine from Iasi,
portant, before starting any autopsy, to consult Romania on 49 cases (32 males and 17 females)
all available data in order to understand discov- that benefited from CPR manoeuvres prior to
ered lesions. Medical documents rarely contain death and whose necropsies were performed
the exhaustive details of all CPR maneuvers between January 2015-December 2016. Medi-
carried out. The reported data may also be er- cal and police files provided by the authorities
roneous, making it difficult to interpret certain were also analysed in order to interpret nec-
lesions (7,8). It is imperative for the forensic ropsy findings. Descriptive statistics (absolute
pathologist to search and precisely identify all values, means, frequencies) were used to report
the lesions secondary to CPR maneuvers in data.
order to determine their possible involvement
in the death process but, above all, not to con- RESULTS
fuse them with the consequences of violent acts The 49 cases had a mean age of 47.3 years.
causing death. 24 cases (48.98%) presented cardiac arrest sec-
One of the difficulties encountered by foren- ondary to trauma (car accident, fall from height,
sic pathologists when performing necropsies is traumatic brain injury, strangulation, crushing,
related to the fact that it is not always facile to stabbing, intoxications). Most cardiac arrests
assert the exact origin of an observed lesion. (41 cases - 83.67%) occurred in an extra-hos-
Sometimes it is difficult to identify all the in- pital environment.
juries related to CPR maneuvers, even for rib CPR duration was reported in 21 cases
fractures whose incompleteness may alter find- (42.86%) and registered a mean value of 42
ings (9). For example, in a Swedish, multi- minutes. Realisation of external cardiac mas-
center study conducted on 222 autopsies of sage was mentioned in the medical files of 26
individuals with non-traumatic cardiac arrest cases (53.06%) and defibrillation in 7 cases
followed by CPR, it was impossible for the 40 (14.29%). Additional gestures like vein punc-
forensic pathologists enrolled to affirm wheth- ture were reported (directly or indirectly) in 20
er identified lesions were due to CPR maneu- cases (40.82%), surgical interventions in 5 cases
vers in 13.5% of cases (10). (10.20%), nasogastric tube insertion in one case
Training of forensic pathology residents (2.04%), thoracic drain insertion (for pneumo-
should pay particular attention to teaching and thorax or pleural effusion) in 3 cases (6.12%).
displaying all the lesions that can be produced Twenty cases (40.82%) were ventilated prior
by resuscitation maneuvers. The realization of to death with 15 tracheal intubations (30.61%).

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Sofia David et al.

At the necropsy examination, no traces of present in 5 cases (10.20%) and holes made by
CPR manoeuvres were identified in 4 cases thoracic drain insertions in 3 cases (6.12%).
(8.16%). In another 10 cases (20.41%) the pre­ Cutaneous lesions and rib fractures are
sence of a puncture site was the only sign of among the most obvious and easy to recognise
CPR. These aspects could be explained by the signs of CPR manoeuvres compared to intra-
presence of severe trauma that made impossible thoracic and intra-abdominal organs lesions that
to identify additional lesions. could erroneously be attributed to other trauma
Intubation injuries were frequently encoun- related to the primary death cause.
tered. Lip lesions (ecchymoses, superficial ero-
sions) were observed in 4 cases (8.16%), dental DISCUSSIONS
lesions (fractures, avulsions) in 2 cases (4.08%), The first elements suggestive for CPR ma-
upper airways haemorrhagic infiltrates (vocal noeuvres at external examination of the body
chords, epiglottis) in 8 cases (16.33%). are represented by lesions of the lips, oral mu-
In the thoracic region, presternal parch- cosa and teeth but no current criterion makes
mented areas and ecchymoses were noted in 7 possible the differential diagnosis with non-
cases (14.29%). Rib fractures were among the resuscitative trauma. The distribution and the
most frequent signs of CPR identified in 16 particular location of these lesions are impor-
cases (32.65%) and associated to haemorrhag- tant key elements that help differentiating them
ic infiltrates corresponding to the fracture line. from those induced by a third-party interven-
Isolated haemorrhagic infiltrates corresponding tion.
to anterior costal arches were observed in 2 Injuries to the oral mucosa may be induced
cases (4.08%). Subjects that had important tho- when securing airways, removing a foreign ob-
racic trauma (car accident, crushing, fall from ject or by vomiting (12) and are capable of
height) with potential of known rib fractures causing bleeding that can be confused with
were excluded from the analysis. A single case haemoptysis (4). Lips were injured in 8.1% of
presented a sternal fracture secondary to car- cases and teeth in 1.1% of cases studied by
diac massage. Generally, of the 26 cases with Krischer et al. (3). The laryngoscope in par-
known cardiac massage, 61.54% presented rib ticular may remove or fracture the incisors (13).
fractures. Ecchymoses and erosions of the scalp, face
Intra-thoracic lesions related to cardiac mas- and neck are currently observed at external
sage were represented by perivascular haemor- examination of patients who have undergone
rhages (7 cases – 14.29%), cardiac petechiae resuscitation (13,14). Even when these wounds
(6 cases – 12.24%, mostly located on the pos- are mild and apparent ordinary, they are impor-
terior surface – 3 cases), and pulmonary contu- tant for the forensic pathologist who must dis-
sion (1 case – 2.04%). tinguish them from those caused by an act of
Intra-abdominal organs were less often the violence. For example, the marks left by fingers
site of complications secondary to resuscita- and nails on the face and neck during resuscita-
tion. Only 3 cases presented lesions of the di- tion attempts are located at the base of the
gestive or retroperitoneal structures that could mandible, around the mouth and between the
be attributed to CPR manoeuvres (haemorrhagic larynx and the maxilla, and are parallel to each
gastritis – 2 cases, haemorrhagic infiltrate of other while lesions produced during strangula-
the retroperitoneum – 1 case). tion are irregularly distributed in multiple di-
Cutaneous lesions were visualised in most rections and cover a large area of the neck (12).
cases. Even though venous punctures were re- Ecchymoses of the nose may also be observed
ported directly or indirectly in the medical files as a consequence of mouth-to-mouth manoeu-
of 20 cases (40.82%), typical lesions were noted vres or application of a facial mask. Conjunc-
in 38 cases (77.55%). Other cutaneous lesions tival petechiae secondary to hypoxia and in-
that could be assimilated to CPR manoeuvres creased capillary pressure can occur in up to
were represented by ecchymoses and erosions 21% of cases and should be differentiated from
on the upper limbs due to movement of the body those appearing secondary to mechanical as-
and encountered in 8 cases (16.33%). Traces phyxia (15).
left by defibrillator paddles were observed in 4 Intubation is associated in about one third
cases (8.16%). Fresh surgical incisions were of the cases with the lesions described above

76
Forensic Significance of Lesions Induced by Cardiopulmonary Resuscitation

and with tracheo-laryngo-pharyngeal injuries. thus imposing the pursuit of other causes (21).
A study of 705 autopsies, published in 1987 by Generally, there are encountered 5-8 rib fractures/
Krischer et al. found them (mucosa lesions, individual depending on the study (4, 7, 21).
lacerations, retropharyngeal haemorrhage, mus­ Sternal fractures occur less often compared
cular haemorrhagic infiltrates, tracheal rupture) to rib fractures, Black et al. discovering them
in 20.4% of cases (3). Severe tracheal lesions in 14% of cases (7). They seem to be related
could indicate an emergency context. especially to automatic chest compression de-
Other lesions involving cervical and diges- vices not used in our country.
tive structures (hyoid bone fractures, laryngeal Perivascular haemorrhagic infiltrations are
cartilages fractures, oesophageal perforations) poorly described in the literature. However,
have been reported in the literature but were they are part of the frequently observed lesions
not observed in our series. These are excep- during necropsy when chest compressions have
tional situations that must be known to forensic been applied and mostly involve the ascending
pathologists (3). Hyoid bone and thyroid carti- aorta, superior vena cava and azygos vein but
lage fractures are often associated with adjacent may extend to the abdominal region in excep-
soft tissue haemorrhage and it is important to tional cases (3).
distinguish them from lesions produced during Petechiae on the surface of the heart, most-
strangulation (16). Haemorrhagic infiltrates ly on the posterior surface, are non-specific to
and fractures occurring in individuals surviving the CPR and no macroscopic criterion distin-
resuscitation for a period of time are more in- guishes them from those arising from mechan-
tense than those observed in death by strangu- ical asphyxia (intentional or criminal) or agony
lation (17). (22). Myocardial lesions (rupture) have also
Thoracic ecchymoses and erosions are the been mentioned in the literature as being re-
first elements that suggest the realisation of lated to chest compressions especially in case
thoracic compressions as part of CPR. Their of increased cardiac pressure like in patients
frequency is variable up to 2/3 of cases that with pulmonary embolism or thinned wall sec-
benefited from manual external cardiac mas- ondary to a myocardial infarction (23). Krischer
sage (3). These lesions occur most frequently et al. observed some rare lesions such as endo-
on the anterior surface of the thorax near the cardial dilaceration, intraventricular haemor-
sternum. Presternal parchmented areas and ec- rhage, epicardial haemorrhage, subendocardial
chymoses appear secondary to electric defibril- contusion (3). His bundle and coronary arteries
lation in up to 53.3% of cases (3) especially if lesions (intimal dilacerations) have been identi-
the electrodes are in direct contact with the skin fied in 44% of cases on histological images (24).
(without interposed conduction gel). All intra-thoracic structures (vessels, peri-
Rib fractures are also among the most fre- cardium, heart, lungs, diaphragm) can be injured
quent complications found in about 1/3 of cases (contusion, rupture, perforation, dilaceration)
(most cases with thoracic compressions) (18). directly or indirectly by chest com­pressions.
Clinical factors such as age and sex (greater The observed lesions can be directly attributed
prevalence of osteoporosis in elderly women), to CPR only in the absence of trauma. Pulmo-
or the depth of chest compressions (more than nary lesions are identified in 13% of cases
6 cm) are associated with their appearance (3, secondary to gastric content inhalation, emphy-
4,7,19). The influence of other factors, such as sema or contusion (3). Pulmonary oedema can-
CPR duration, the experience of the person not be directly considered a complication of
performing cardiac compressions (medical per- CPR but a consequence of prolonged manoeu-
sonnel or witness) is still uncertain (13,20). vres. Pneumothorax, haemothorax (azygos vein
They are practically non-existent in children rupture) and subcutaneous emphysema can also
and infants given the elasticity of the chest wall complicate chest compressions (25). Diaphrag-
at these ages (21). Most rib fractures occur matic lesions are rare same as vertebral fractures.
between the parasternal and anterior axillary Intra-abdominal organs such as the liver,
lines and involve the 2nd to the 6th (7th) rib spleen and stomach are less often the site of
mostly on the left side when hands are cor- complications secondary to resuscitation than
rectly applied (21). Fractures of the 1rst, 8th and the structures mentioned above. However, due
12th rib are rare same as posterior arch fractures to their anatomical location, secondary lesions

77
Sofia David et al.

(rupture, perforation, dilaceration) may be ob- and underlying haemorrhagic infiltrations are
served directly related to chest compressions very often a sign of CPR especially if located
or indirectly related, mainly through bone frac- in specific anatomic regions (cubital fossa, dor-
tures. An improper hand position could facili- sal hand). Nevertheless, no criterion, makes it
tate the occurrence of these type of injuries possible to distinguish these lesions from those
(13). Krischer et al. identified liver lesions in provoked by an act causing death (self-injection
2.1% of cases (3) compared to 0.32% in an- or administration by a third party of toxic or
other study (26). Similarly, only 3 cases of narcotic drugs). Nearly 80% of these lesions
post-CPR splenic fracture have been indicated are observed in individuals who have benefited
in the literature (27). from intensive care manoeuvres. The precise
Digestive lesions associated with ventilation origin of each of these punctures must be strict-
manoeuvres are most commonly observed in ly checked in order not to omit any malicious
emergency situations where malposition of the intervention by a third party or self-injection
intubation tube is frequent and may result in (suicide, drug abuse) (3).
oesophageal intubation. This can lead to oe- Buschmann et al. and Krischer et al. indi-
sophageal and gastric lesions, sometimes as far cate some other potential and rare lesions oc-
as gastric distension (29.1%) (3), even associ- curring during CPR such as those involving the
ated with pneumoperitoneum and subcutaneous recurrent nerves, piriform sinus, vocal cords
emphysema if CPR is continued (28). Signs like and arytenoid cartilages (3,6). Hyperextension
cyanosis and abdominal distension indicate a of the head during CPR may lead to fractures
malposition of the tube (6). Such complications of the cervical spine, or even dilacerations of
can also occur during mouth-to-mouth respira- carotid intima (3,30). Mechanical ventilation is
tions or when using a facial mask (29). Gastric a potential source of pulmonary barotrauma
distension may be complicated by lacerations which can be complicated by pneumothorax and
and bleeding (9-12%) especially in association subcutaneous emphysema (31).
with chest compressions (4). Gastric ruptures In common practice, when CPR has been
occur rarely and below the gastroesophageal performed, the absence of any other explana-
junction, parallel to the lesser curvature (28). tion for certain wounds discovered at necropsy
Ecchymoses, erosions and haemorrhagic in- sometimes leads to the conclusion that CPR is
filtrations of the inner side of the upper limbs directly responsible for them. Anamnestic ele-
occurring secondary to body manipulation dur- ments detailed in medical or police files are
ing resuscitation, are rarely mentioned in the essential and must be exhaustive in order to
literature, probably due to the lack of repercus- ensure a certain link between lesions and CPR.
sions. On the other hand, they have particular
forensic implications because of their specific CONCLUSIONS
location as they may suggest the intervention Injuries produced during CPR may be re-
of a third party potentially related to the pri- sponsible for important artefacts impeding the
mary cause of death. It is therefore important understanding of traumatic lesions observed
to find precise anamnestic elements concerning during necropsy and related to the primary
the gestures and manipulations performed dur- death cause. A thorough knowledge of possible
ing resuscitation manoeuvres. aspects is mandatory to the differential diagno-
Puncture sites associated with ecchymoses sis with other traumatic lesions.

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Corresponding author

Sofia David
ddavid.sofia@yahoo.com

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