Professional Documents
Culture Documents
Suppository, Insert & Stick
Suppository, Insert & Stick
− Relieve constipation
SUPPOSITORY − Relieve pain, irritation, itching, and
• Latin: supponere; means to place under (sub inflammation associated with
– under; ponere – to place) hemorrhoids/anorectal conditions
• Solid dosage form in which API’s are
dispersed in a suitable base and molded into *see table 12.1 for examples*
a suitable shape
• Intended for insertion into body orifices • Vaginal Suppositories or Inserts
where they melt, soften, or dissolve − pessaries
• Exert local or systemic effects − Contraceptives, antiseptics
INSERTS Examples:
• Solid dosage form inserted into a naturally Nonoxynol 9 Contraception
occurring or nonsurgical body cavity rather Combat vaginitis
than the mouth or rectum, including the caused by
Trichomonacides
vagina and urethra Trichomonas
Vaginalis
Treat Candida
STICKS Antifungals
(Monilia) albicans
• Convenient form for administering topical Directed at other
Anti-infectives/antibiotics
drugs organisms
• Local effect
• hydration/emollient, antibacterial, sunscreen, *see table 12.2 for more examples*
antipruritic
• Involves the history of cosmetics • Urethral Inserts
− bougies
DIFFERENCES IN TERMS OF APPEARANCE, SIZE, − Antibacterial, local anesthetic
AND SHAPE
Appearance Size Shape Systemic Action
• Mucous membrane of the rectum and vagina
Suppositories Have one or permit the absorption of many soluble drugs.
32 mm cylindrical
a. Rectal both ends
tapered • NOTE: Rectum is used frequently as the site for
Globular, the systemic absorption of drug (vagina is nor
Inserts 5 g (with
oviform or frequently used)
a. Vaginal cocoa
cone
(pessaries) butter base
shaped
Male: 3- Examples:
6mm Prochlorperazine & Tranquilizer; relief of
diameter; Chlorpromazine N&V
b. Urethral 140mm Pencil-
(bougies)
slender Morphine &
long shaped Opioid analgesia
Oxymorphone
Female: 70 Indomethacin Analgesic, antipyretic
mm long Relief of migraine
Packed in Ergotamine tartrate
syndrome
Sticks applicator 5-25 g cylindrical
tubes
Ondansetron Relief of N&V
Hydromorphone Analgesic
Antihistamine,
USES AND APPLICATIONS OF SUPPOSITORIES Promethazine HCl
antiemetic, sedative
Local Action
• Once inserted, suppository base melts, softens FACTORS OF DRUG ABSORPTION FROM RECTAL
or dissolves. SUPPOSITORIES
• Medicaments are distributed to the tissues of Physiological Factors
the region. • Circulation Route
− Intended for retention within the cavities − Drugs absorbed rectally can bypass the
(local effect) portal circulation during their first pass
− Intended to be absorbed (systemic into the general circulation, which
effects)
GLYCERIN SUPPOSITORIES
• popular laxatives
• Promote laxation by local irritation of the
mucous membranes through the dehydrating
effect of the glycerin on those membranes.
CLINICAL CONSIDERATIONS
Regarding suppositories, patients should be
informed about the following:
1. proper storage conditions for both
prescription and nonprescription products
2. how to unwrap a wrapped suppository
3. how to resolidify a melted suppository
4. proper insertion of the suppository
5. reasonable estimate of the time after which
the medication should be discarded
suggested by the pharmacist
individually wrapped;
separated in
Cocoa Butter Based
compartmented boxes
Suppository
to prevent contact or
adhesion
individually wrapped in
Suppository Containing
an opaque material
Light Sensitive Drugs
such as metallic foil
individually wrapped in
either foil or plastic
Other Commercial in continuous strip,
Suppositories separated by tearing
along perforations
slide or plastic boxes