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  • Hksa 2

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    anggry
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    This document presents 7 regression equations relating the log of inhibitor concentration (Log I/I50) to various parameters including the log of diffusion coefficient (log D), log of partition coefficient (log P), and acid dissociation constant (pKa). Each equation shows the regression statistics including p-value, correlation coefficient (R), F-value, and standard deviation (s) indicating the best fit is equation 7 which includes log P, log P2, and pKa with an R value of 0.912.

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    This document presents 7 regression equations relating the log of inhibitor concentration (Log I/I50) to various parameters including the log of diffusion coefficient (log D), log of partition coefficient (log P), and acid dissociation constant (pKa). Each equation shows the regression statistics including p-value, correlation coefficient (R), F-value, and standard deviation (s) indicating the best fit is equation 7 which includes log P, log P2, and pKa with an R value of 0.912.

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    6 views1 page

    Hksa 2

    Uploaded by

    anggry
    This document presents 7 regression equations relating the log of inhibitor concentration (Log I/I50) to various parameters including the log of diffusion coefficient (log D), log of partition coefficient (log P), and acid dissociation constant (pKa). Each equation shows the regression statistics including p-value, correlation coefficient (R), F-value, and standard deviation (s) indicating the best fit is equation 7 which includes log P, log P2, and pKa with an R value of 0.912.

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    of 1

    No Parameter Persamaan

    1 Log I/I50 VS log D Log I/I50 = 0,354 log D + 2,197


    P= 0,000 R= 0,737 F= 44,029 s=0,52
    2 Log I/I50 VS log P Log I/I50 = 0,435 log P + 1,834
    P= 0,000 R= 0,746 F= 46,538 s= 0,51
    3 Log I/I50 VS log D,log P Log I/I50 = 0,403 log D – 0,077 pKa + 2,761
    P= 0,000 R= 0,764 F= 25,214 s= 0,50
    4 Log I/I50 VS log P, pKa Log I/I50 = 0,491 log P + 0,128 pKa +0,580
    P= 0,000 R= 0,830 F= 39,731 s= 0,43
    5 Log I/I50 VS log D, log D2 Log I/I50 = 0,296 log D + 0,047 log D2 + 2,000
    P= 0,000 R= 0,808 F= 33,890 s= 0,46
    6 Log I/I50 VS log P, log P2 Log I/I50 = 1,135 log P – 0,102 log P2 + 0,880
    P= 0,000 R= 0,873 F= 57,928 s= 0,38
    7 Log I/I50 VS log P, log P2, Log I/I50 = 1,080 log P – 0,088 log P2+ 0,096 pKa + 0,072
    pKa P= 0,000 R= 0,912 F= 58,047 s=0,32

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