Pathology RBC Values - Shivaan Oomrigar

Iron Deficiency Anemia of Chronic Sideroblastic Anemia Major Minor Thalassemia

Anemia (IDA) Disease (AOCD) Hydrops Fetalis
Mechanism Dietary Lack Infections Insufficient heme synthesis production of Moderate All 4 chains
Impaired Absorption Inflammations Mito defects in iron pthwy chains reduction in deleted
Inc Fe requirements Certain malignancy Ineffective erythropoiesis chains
Chronic Blood Loss IL-1, TNF, IFN-g: Iron deposits in RBC mito Total absence of tetramer =
- Hepcidin synthesis chains HbBarts
- Renal EPO - excess chains
Hb
Hct - - -
MCV
Serum Fe normal
% Saturation normal
Serum Ferritin normal normal
TIBC - -
Transferrin - -
Hemosiderin
P. Smear Microcytic Normocytic Normocytic, macrocytic or Microcytic Mild Microcytic Target Cell
Hypochromic Normochromic microcytic = Dimorphic Anisopoikilocytosis Target cell - inconsistently
Central pallor transform into Target Cell - consistently
Anisopoikilocytosis Microcytic Nucleated Red Cell Nucleated Red Cell
Pencil cells Hypochromic n-RBC
Pappenheimer bodies Xray: Hair on End
- iron deposits in mat RBC
Bone Hyperplastic Normal Hyperplastic Reticulocytes = RBC Count = RBC count =
Marrow Iron = 0 Iron = +++ Sideroblastic Rings! HbA2 = HbA2 =
M0 iron = normal or Iron = +++ HbF = HbF =
HbA = HbA =
Uncoj Bilirubin =
Other % saturation = Special Test Expression Hb Electroporesis Hb Hb
FEP = of mito ferritin = - confirmatory Electroporesis Electroporesis
- abnormal - confirmatory - normal
- abnormal
 Pathology RBC Values - Shivaan Oomrigar
Urine Sample
Erythropoietic porphyria