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Stago Newsletter
Volume 6 Issue 1 May 2016
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Haemostasis Catalogue 2016

INSIDE THIS ISSUE:

2016 Haemostasis Catalogue 2

VWF Collagen Binding 3

Customer Corner 4

iHemOStasis and Haemoscore 5

Continuing Education 6

STart Max 7

Stago Prize 2015 RMIT 8

Dates to Remember 9
Our new 2016 Stago and Tcoag Haemo-
stasis Catalogues are now available in
hardcopy or softcopy. If you would like to
receive a copy of either or both please let
us know which version you would prefer
and where you are from.

info@stago.com

VWF: Collagen Binding
Von Willebrand Disease (VWD)
is the most common inherited
bleeding disorder. Clinically, it is
often characterised by muco-
cutaneous haemorrhages.
Three principal types of VWD
have been defined:
• Type 1 corresponds to a
quantitative deficiency of
VWF; classically, type 1 is
the most frequently encoun-
tered (70 to 80% of VWD);
however, this notion is un-
der discussion;
• Type 2 refers to a qualita-
tive deficiency of VWF; the
defect is often located in the
multimeric structure;
• Type 3 is characterized by
virtually a total absence of
VWF in both the plasma
and cellular compartments.
Furthermore, VWF deficiencies
may be associated with several
clinical states such as myeloma,
lymphoma, systemic lupus ery-
* Informa on source - 00239 Stago Asserachrom VWF:CB Package Insert
thematosus, hypothyroidism, etc.
These cases may be referred to
as acquired von Willebrand dis-
eases.
Von Willebrand Factor Colla-
gen-Binding Ability
Only the VWF functional multi-
mers of high molecular weight
can bind to collagen. A decrease
VWF:CB level reflects a quantita-
tive or qualitative disorder of the
VWF multimers. The ratio value
of [VWF:CB]/[VWF:Ag] is useful
to differentiate type 2 subtypes of
VWD in which a loss of HMWM
occurs. This assay allows one to
distinguish the subtype 2A (very
decreased [VWF:CB]/[VWF:Ag]
ratio) from the subtype 2M
(normal or slightly decreased
[VWF:CB]/[VWF:Ag] ratio).
00239 Asserachrom® VWF:CB
TEST PRINCIPLE
The VWF to be measured is cap-
tured through the HMWM by hu-
3
man collagen (Reagent 1) coat-
ed on the internal walls of a plas-
tic microplate well. Next rabbit
anti-VWF antibodies coupled with
peroxidase (Reagent 2) bind to
the remaining free antigenic de-
terminants of the bound VWF.
The bound enzyme peroxidase is
revealed by its action on the TMB
substrate (Reagent 3). After stop-
ping the reaction with a strong
acid, the intensity of the colour is
directly proportional to the con-
centration of the VWF:CB initially
present in the plasma sample.
The Stago Asserachrom®
VWF:CB kit is an assay for the
quantitative determination of the
capacity of von Willebrand factor
to bind to collagen (VWF:CB) by
enzyme-linked immunosorbent
assay (ELISA).
If you would like a quotation or
more information please contact
us at:
info@stago.com
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Stago Customer Corner

Stago Customer Corner is
available via our new-look
website
www.stago.com.au

You simply log-in (clicking

the Login button top right)
and you will get access to
all your data and available
services.

The information available

includes: your laboratory
analysers, orders and ID-
card; Material Safety Data
Sheets, Package Inserts,
Barcode Sheets, Instru-
ment Documents, and
Standard Operating Pro-
cedures

If you would like access to

Customer Corner please
contact us for your log-in
and password - it’s free !

info@stago.com
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iHemOStasis and Haemoscore -

Stago Apps for iPad and Android
Stago are pleased to announce the re-
lease of our block buster applications
iHemOStasis and Haemoscore. These
applications are available free of charge
from the Apple App Store and Google
play worldwide.

The iHemOStasis tablet application

serves as a haemostasis primer for
anyone looking to increase
knowledge in the area. The uncompli-
cated user interface offers four areas
of interest:
Coagulation Cascade: Major coagulation
mechanisms are animated along with
detailed explanations of each phase,
including intracellular and extracellular
components.
Quick Guide: Detailed descriptions of the
most current assays used to examine
hemostasis in a global fashion along with
various therapies, disease state classifi-
cations and decision trees.
Special Focus: Product literature sup-
porting Stago’s anticoagulant, thrombin
generation and flow cytometry products
is housed, along with reference ranges
for hemostasis tests in childhood and
pregnancy.
Clinical Cases: Three case studies are
presented, along with quizzes to test the
viewer’s knowledge.
The Haemoscore App is available for
tablet and smartphone from the Apple
Store and Google play.
Clinical scores and algorithms play a
central role in modern patient care de-
rived from evidence-based medicine.
Evidence based medicine provides
guidelines to physicians aimed at im-
proving efficacy and safety of patient
management.
An international expert panel has devel-
oped this application that compiles, in a
clear and simples way, most recognised
and useful clinical scores and diagnosis
algorithms in the field of Thrombosis and
Haemostasis.
Each algorithm includes the indication
and a brief interpretation emphasising
the most relevant aspects of each one
followed by some representative refer-
ences.
We hope this application may guide the
clinician in the most appropriate diagnos-
tic strategy, answering some of the
questions that may arise when treating
thrombotic and bleeding problems.

Continuing Education
Diagnostica Stago has a number of
websites to assist in the continuing
education of your staff. On a regular
basis Stago hosts live webinars at a
range of times, to suit us in Australia
and New Zealand, presented by Key
Note Speakers from laboratories from
around the world.
These webinars are also available for
viewing “on demand” a few weeks
after the live presentation.
The topics covered so far include:
1. D-Dimers Its use in the Strategy for
VTE exclusion and as a predicator for
the risk of VTE recurrence
2. How to diagnose and manage Hep-
arin Induced Thrombocytopenia
(HIT) ?
3. Laboratory measurement of New
oral Anticoagulants
4. New insights in Lupus Anticoagu-
lant Testing
5. Quality Control in the Haemostasis
Laboratory. How Quality Control con-
tributes to result reliability.
6. Thrombin Generation: a universal
laboratory tool emerging from re-
search to clinical practice
7. How I interpret an APTT result?
8. The laboratory diagnosis of inherit-
ed and acquired Haemophilia
9. Disseminated Intravascular Coagu-
lation: pathophysiology and diagnosis,
contribution of the clinical lab and im-
portance of Fibrin-related markers
10. Heparin monitoring – Here to
stay ! (Which screened May 24, 2016)
The above webinars are currently all
available to view on demand. All you
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need to do is go to the Stago ANZ
website www.stago.com.au and press
the icon Stago Webinars (see below).
This link will take you to the webinars
website where you register for access
and future webinar notifications. The
webinars are best viewed using
Google Chrome and SD (standard
definition) depending on your connec-
tion speed.
Another link on our Stago website
“Ed-Vantage Continuing Educa-
tion” provides access to a huge
amount of resources covering topics
such as Lab Management, General
Coagulation Testing, Case Studies in
Hemostasis, Primary Hemostasis,
Anticoagulation, Hypercoagulability,
Hypocoagulability, and Screening
Tests. Some of these talks also at-
tract PACE points.
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®
STart Max

Would you like to know more?

Contact us:
info@stago.com

2015 RMIT Science and
Health Student Prizes
Jaelyne Birrell receives The Stago Prize at RMIT Awards Ceremony from Vicki Guppy Scien$fic and Training Manager Stago ANZ
Congratula ons to Jaelyne Birrell for winning
the Stago Prize awarded to the best Bachelor of
Biomedical Science (Laboratory Medicine) stu-
dent in their final year of study at RMIT in 2015.
Not only did Jaelyne win the Stago Prize she al-
so won the School of Medical Sciences Prize
awarded to the best student from an under-
graduate program in the School of Medical Sci-
ences in 2015 as well as the Pro Vice-Chancellor
Health Prize awarded to the best student in
their final year of a Health program, selected on
academic achievement and contribu ons to
School and University ac vi es.
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And that is not all for awards . At the RMIT Uni
School of Medical Sciences and AIMS Lab Medi-
cine Student Awards Night (May 24, 2016)
Jaelyne received Top Student in Microbology,
Top Student in Pathology, Top Graduate in BBi-
omedSci in Lab Medicine, Top 10% of Gradu-
ates, Top Fourth Year Student, and the IBMS
President’s Prize awards.
Jaelyne is a Microbiologist with Microgene x, a
molecular microbiology company in Mel-
bourne, where she performs DNA sequencing
to iden fy microorganisms to species level.
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Dates to Remember

Diagnostica Stago Pty. Ltd.

651 Doncaster Road
Doncaster, VIC, 3108
Australia
Phone (AUS): 1800 4 STAGO
Phone (NZ): 0508 4 STAGO
Fax: +61 3 9855 8999
info@stago.com AUSTRALIA - NEW ZEALAND

www.stago.com.au At the Heart of Haemostasis