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    Pengujian Aktivitas Lokomotor Pada Mencit Jantan Yang Diinduksi Diazepam Dan Kafein Dengan Metode Wheel Cage Test

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    meydiana ivanka
    This document is a research proposal that will examine the locomotor activity of male mice induced with diazepam and caffeine using the wheel cage test method. The study aims to fulfill the requirements of the Pharmacotherapy Practicum for Skin, Bone and Joint, Eye, Ear Nose and Throat, Neurological and Psychiatric Disorders at the Padjadjaran University Faculty of Pharmacy. It will involve reviewing literature on depressant and stimulant drugs, locomotor activity assessment methods, and describing the research methods, tools, materials, treatment of test animals, and statistical analysis.

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    Pengujian Aktivitas Lokomotor Pada Mencit Jantan Yang Diinduksi Diazepam Dan Kafein Dengan Metode Wheel Cage Test

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    meydiana ivanka
    70 views7 pages
    This document is a research proposal that will examine the locomotor activity of male mice induced with diazepam and caffeine using the wheel cage test method. The study aims to fulfill the requirements of the Pharmacotherapy Practicum for Skin, Bone and Joint, Eye, Ear Nose and Throat, Neurological and Psychiatric Disorders at the Padjadjaran University Faculty of Pharmacy. It will involve reviewing literature on depressant and stimulant drugs, locomotor activity assessment methods, and describing the research methods, tools, materials, treatment of test animals, and statistical analysis.

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    This document is a research proposal that will examine the locomotor activity of male mice induced with diazepam and caffeine using the wheel cage test method. The study aims to fulfill the requirements of the Pharmacotherapy Practicum for Skin, Bone and Joint, Eye, Ear Nose and Throat, Neurological and Psychiatric Disorders at the Padjadjaran University Faculty of Pharmacy. It will involve reviewing literature on depressant and stimulant drugs, locomotor activity assessment methods, and describing the research methods, tools, materials, treatment of test animals, and statistical analysis.

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    70 views7 pages

    Pengujian Aktivitas Lokomotor Pada Mencit Jantan Yang Diinduksi Diazepam Dan Kafein Dengan Metode Wheel Cage Test

    Uploaded by

    meydiana ivanka
    This document is a research proposal that will examine the locomotor activity of male mice induced with diazepam and caffeine using the wheel cage test method. The study aims to fulfill the requirements of the Pharmacotherapy Practicum for Skin, Bone and Joint, Eye, Ear Nose and Throat, Neurological and Psychiatric Disorders at the Padjadjaran University Faculty of Pharmacy. It will involve reviewing literature on depressant and stimulant drugs, locomotor activity assessment methods, and describing the research methods, tools, materials, treatment of test animals, and statistical analysis.

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    PENGUJIAN AKTIVITAS LOKOMOTOR PADA MENCIT

    JANTAN YANG DIINDUKSI DIAZEPAM DAN KAFEIN


    DENGAN METODE WHEEL CAGE TEST

    USULAN PENELITIAN

    Diajukan untuk memenuhi tugas Praktikum Farmakoterapi Gangguan Kulit,


    Tulang dan Sendi, Mata, THT, Syaraf dan Psikiatri pada Fakultas Farmasi
    Universitas Padjadjaran

    Shift A 2017
    Kelompok 4
    Elmira Rachma A. 260110160027
    Adhitiya Daniyal 260110160028
    Irawati Nur Hidayah 260110160029
    Sidka Muhdiati 260110160030
    Dina Hawari 260110160031
    Mutiara Tonthawi 260110160032
    Destri Yulia R. 260110160033
    Hikmah Presa A. 260110160034

    FAKULTAS FARMASI
    UNIVERSITAS PADJADJARAN
    JATINANGOR
    2018
    2

    BAB 1

    PENDAHULUAN

    1.1 Latar Belakang Penelitian

    1.2 Identifikasi Masalah

    1.3 Tujuan Penelitian

    1.4 Kegunaan Penelitian

    1.5 Metode Penelitian

    1.6 Lokasi dan Waktu Penelitian

    BAB II

    TINJAUAN PUSTAKA
    3

    2.1 Obat-Obat Golongan Depresan (Sedatif-Hipnotik)

    2.2 Obat-obat Golongan Stimulan

    2.3 Aktivitas Lokomotor

    2.3.1 Metode Running Wheels

    2.3.2 Open Field Locomotion Test

    2.3.3 Home Cage Activity


    BAB III

    METODE PENELITIAN

    3.1 Alat

    3.2 Bahan

    3.3 Metode Penelitian

    3.3.1 Perlakuan terhadap Hewan Uji Sebelum Pengujian.

    13
    5

    3.3.2 Pengujian Aktivitas Lokomotor dengan Metode Roda Putar (Wheel

    Cage)

    3.3.3 Analisis Statistika


    DAFTAR PUSTAKA

    Adongo, D. W., Mante, P.K., Woode, E., Ameyaw, E.O., dan Kukuia, K. K. E.
    2014. Effects of Hydroethanolic Leaf Extract of Pseudospodians
    microcarpa (A. Rich.) Engl. (Anacardiaceae) on the Central Nervous
    Sistem in Mice. Journal Phytopharmacology. 3(6): 410-417.
    Charter, M. dan Shich, J. C. 2010. Guide to Research Techniques in Neuroscience
    (Second Edition) Chapter 2: Animal Behavior. UK : Academic Press.
    Ferré, S., Ciruela, F., Borycz, J., Solinas, M.., Quarta, D., et al. 2008. Adenosine
    A1-A2A receptor heteromers: new targets for caffeine in the brain. Front
    Biosci. 13: 2391-9, Review.
    Ferré, S. 2010. Role of the central ascending neurotransmitter sistems in the
    psychostimulant effects of caffeine. J Alzheimers Dis 20 Suppl. 1: S35-49.
    Fredholm, B. B. , Battig, K., Holmen, J., Nehlig, A., dan Zvartau, E. E. 1999.
    Actions of caffeine in the brain with special reference to factors that
    contribute to its widespread use. PharmacolRev. 51: 83-133.
    Griffiths, R. R., Juliano, L. M., dan Chausmer, A. 2003. Caffeine: Pharmacology
    and Clinical Effects. In Principles of Addiction Medicine, Graham AW,
    Schultz TK, Mayo-Smth MF, Ries RK, Wilford BB, eds, Third Edition,
    Chevy Chase: American Society of Addiction Medicine. pp. 193-224.
    Gunawan, G. S.. 1995. Farmakologi dan Terapi, Edisi IV. Jakarta : Balai Penerbit
    Fakultas Kedokteran Universitas Indonesia.
    Gunawan, G. S. 2007. Farmakologi dan Terapi, Edisi V. Jakarta :Penerbit Gaya
    Baru.
    Hahn, D. B. dan Payne, W.A. 2003. Focus on Health, Sixth Edition. USA: Mc.
    Graw Hill.
    Houssay, A. 1995. Sleep In : Human physiology. 2 nd ed. London : McGraw-Hill
    Book Company Inc.
    Katzung, B.G. 1996. Buku Bantu Farmakologi. Dialihbahasakan Staff Dosen
    Farmakologi Fakultas Kedokteran Universitas Sriwijaya. Jakarta: Penerbit
    Buku Kedokteran EGC.
    Maughan, R. J., dan Griffin, J. 2003. Caffeine ingestion and fluid balance: A
    review. Human nutrition dietetics. 16: 411-20.
    Muchtaridi, Musfiroh, I., Subarnas, A., Rambia, I., Suganda, H., dan Nasrudin, M.
    E. 2014. Chemical Composition and Locomotors Activity of Essential Oils
    from the Rhizome, Stem, and Leaf of Alpinia malaccencis (Burm F.) of

    15
    Indonesian Species. Journal of Applied Pharmaceutical ScienceI. 4(01):
    052-056.
    Neal, M. J. 2005. At A Glance Farmakologi Medis. Jakarta: Penerbit Buku EGC.
    Nehlig, A., Daval, J. L., dan Debry, G. 1992. Caffeine and the central nervous
    sistem: mechanisms of action, biochemical, metabolic and
    psychostimulant effects. Brain Res Brain Res Rev. 17:139–70
    Nino dan Murcia. 1992. Management of Insomnia. In : Hardman, J.G. ; Limbird,
    L.E., editors : Goodman & Gilman’s The pharmacological Basis of
    Therapeutics. 10th ed. New York : McGrawHill.
    Orru, M., Guitart, X., Karcz, K. M., Solinas, M., Justinova, Z., et al. 2013.
    Psychostimulant pharmacological profile of paraxanthine, The main
    metabolite of caffeine in humans. Neuropharmacology. 67: 476-84.
    Priguna, S.1979. Neurologi Klinis dalam Praktek Umum. Jakarta : Dian Rakyat.
    Siswandono dan Soekardjo, B. 2000. Kimia Medisinal. Edisi 2, 228-232, 234, 239.
    Surabaya: Airlangga University Press
    Sukandar, E. Y. 2011. ISO Farmakoterapi. Jakarta: PT. ISFI.

    16

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