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  • Copd Patho

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    Rey Angelo
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    This document outlines the predisposing and precipitating factors, pathogenesis, and physiological effects of chronic obstructive pulmonary disease (COPD). The predisposing factors include age of 56 years old and a smoking history of 35 pack years. Occupational exposures also contributed. The disease process involves inflammation, increased enzymes and cytokines, destruction of lung tissue, fibrosis, and impaired gas exchange. This results in symptoms such as shortness of breath, hypoxemia, and respiratory acidosis.

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    Pathophysiology of COPD

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    This document outlines the predisposing and precipitating factors, pathogenesis, and physiological effects of chronic obstructive pulmonary disease (COPD). The predisposing factors include age of 56 years old and a smoking history of 35 pack years. Occupational exposures also contributed. The disease process involves inflammation, increased enzymes and cytokines, destruction of lung tissue, fibrosis, and impaired gas exchange. This results in symptoms such as shortness of breath, hypoxemia, and respiratory acidosis.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    362 views1 page

    Copd Patho

    Uploaded by

    Rey Angelo
    This document outlines the predisposing and precipitating factors, pathogenesis, and physiological effects of chronic obstructive pulmonary disease (COPD). The predisposing factors include age of 56 years old and a smoking history of 35 pack years. Occupational exposures also contributed. The disease process involves inflammation, increased enzymes and cytokines, destruction of lung tissue, fibrosis, and impaired gas exchange. This results in symptoms such as shortness of breath, hypoxemia, and respiratory acidosis.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 1

    Predisposing Factors Precipitating Factors

    Age = 56 y/o Smoking 35 pack years

    Occupational Exposure

    Inflammation

    Inc. neutrophil elastase Inc. oxidative stress, Mucus hypersecretion


    and matrix inflammatory mediators, Ciliary dysfunction
    metalloproteinases cytokines

    Destruction of alveolar Fibrosis and thickening of Edema and smooth


    walls and capillaries the bronchial walls muscle contraction

    Enlarged air Impaired gas Air trapping Narrowing of


    spaces diffusion on expiration small airways

    Chronic
    Emphysema
    bronchitis

    Inc. lung Destruction of Air trapping


    Airway Mucus
    compliance capillary bed on expiration
    obstruction Hypersecretion

    Matched Inc. RV Alveolar


    V:Q defect Inc. TLC hypoxia
    Dec. VC

    Inc. work of V:Q Mismatch Pulmonary


    breathing Vasoconstriction

    Hypoxemia Hypercarbia Pulmonary


    Dyspnea Cachexia hypertension

    Polycythemia Respiratory
    Acidosis

    Cyanosis

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