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Gastrointestinal Tuberculosis: Pathogenesis
Gastrointestinal Tuberculosis: Pathogenesis
Sexual Transmission
Gastrointestinal Tuberculosis
PATHOGENESIS
PRECIPITATING FACTORS
PREDISPOSING FACTORS
Lifestyle: Alcoholic drinker
Age Environment
1. Selective Tropism for CD4
Immunocompromised
molecule receptor
Systemic Infection: HIV/AIDS
2. Internalization
Ingestion of sputum (lymphatic
drainage) hematogenous or
3. Uncoating & viral DNA adjacent organs
formation
5. Viral replication
GI macrophages phagocytosize the bacilli
Susceptibility of the patient to T-bacilli produce proteins that inhibit the fusion
8. Viral dissemination various infections producing from the lysosome to avoid the hydrolytic acid
certain complications produce by the lysosomal organelles
Ghon focus: granuloma created to wall off bacteria