The presence of two or more of the following four criteria, one of which

must be abnormal temperature or white blood cell count:

 Core temperature (rectal, bladder, oral, or central catheter probe)
>38.5°C (101.3°F) or <36°C (96.8°F)
 Abnormal WBC count or >10% immature neutrophils
 Tachycardia or bradycardia
 Mean RR >2 standard deviations for age or mechanical ventilation for
an acute process not related to an underlying neuromuscular disease
or to general anesthesia

NEONATES NEONATES
Does the patient have documented maternal risk NEUROLOGIC: convulsions, drowsy or unconscious, decreased
factors like one of the following? activity, bulging fontanel
 History of UTI last semester RESPIRATORY: respiratory rate >60 breaths/min, grunting, sever
 Membranes ruptured >18h before delivery chest indrawing, central cyanosis
 Fever >38C before delivery or during labor CARDIAC: poor perfusion, rapid and weak pulse
 Foul-smelling or purulent amniotic fluid GI jaundice, poor feeding, abdominal distention
DERMA: skin pustules, periumbilical erythema or purulence
MSK edema or erythema overlying bones or joints
OTHER: Temperature >37.7°C (99.9°F; or feels hot) or
POTENTIALLY SEPTIC NEONATE
<35.5°C (95.9°F; or feels cold)

Preferred regimen: Preferred regimen:

Ampicillin + Gentamicin OR Amikacin 1st line 2nd line
See NAG for dosing per age and weight, p.25 Cefotaxime OR Ceftriaxone Ceftazidime + Gentamicin OR
+ Amikacin
Gentamicin OR Amikacin

WITH or WITHOUT
Oxacillin OR Vancomycin
If asymptomatic and
blood cultures are
negative after48-
72hrs

negative CRP at 72h

Discontinue antibiotics