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  • Pathophysiology of Ugib

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    Chombe Jc
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    Age, gender, and race are non-modifiable risk factors for upper gastrointestinal bleeding, while long-term aspirin use and coffee intake are contributing and modifiable risk factors, respectively. These factors can elicit effects on cyclooxygenase, impair mucosal defenses to acid, disrupt the mucous barrier, cause epigastric pain and ulcers that burrow into the gastro-duodenal mucosa, thin arterial walls, and cause weakened walls to rupture, resulting in upper gastrointestinal bleeding that presents as melena, low hemoglobin levels, and symptoms like lightheadedness, weakness, and pale skin and conjunctiva.

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    Age, gender, and race are non-modifiable risk factors for upper gastrointestinal bleeding, while long-term aspirin use and coffee intake are contributing and modifiable risk factors, respectively. These factors can elicit effects on cyclooxygenase, impair mucosal defenses to acid, disrupt the mucous barrier, cause epigastric pain and ulcers that burrow into the gastro-duodenal mucosa, thin arterial walls, and cause weakened walls to rupture, resulting in upper gastrointestinal bleeding that presents as melena, low hemoglobin levels, and symptoms like lightheadedness, weakness, and pale skin and conjunctiva.

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    61 views1 page

    Pathophysiology of Ugib

    Uploaded by

    Chombe Jc
    Age, gender, and race are non-modifiable risk factors for upper gastrointestinal bleeding, while long-term aspirin use and coffee intake are contributing and modifiable risk factors, respectively. These factors can elicit effects on cyclooxygenase, impair mucosal defenses to acid, disrupt the mucous barrier, cause epigastric pain and ulcers that burrow into the gastro-duodenal mucosa, thin arterial walls, and cause weakened walls to rupture, resulting in upper gastrointestinal bleeding that presents as melena, low hemoglobin levels, and symptoms like lightheadedness, weakness, and pale skin and conjunctiva.

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    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
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    of 1

    V.

    Pathophysiology

    NON MODIFIABLE FACTORS: CONTRIBUTING FACTORS: MODIFIABLE FACTORS:


    Age, Gender and Race Aspirin intake for 5 years Coffee intake

    Elicit their effects on the Cyclooxygenase

    Impaired mucosal defense to acid

    Disruption of mucous barrier

    Epigastric pain Ulcer burrows deep into the gastro


    duodenal mucosa

    Thinning of the arterial walls

    Weakened walls ruptured

    UPPER GASTRO INTESTINAL


    BLEEDING

    Melena

    Low Hemoglobin Level

    Light headedness and Pallor, poor skin turgor


    weakness and poor capillary refill

    Pale Palpebral conjunctiva

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