Budipine

Budipine (brand name Parkinsan) is an

antiparkinson agent marketed for the
treatment of Parkinson's disease.[2][3][1]
ChEMBL ChEMBL334491  

CompTox Dashboard DTXSID20206709

(EPA)
ECHA InfoCard 100.055.494

Chemical and physical data

Formula C21H27N
Molar mass 293.446 g/mol g·mol−1
3D model (JSmol) Interactive image

SMILES
c1(ccccc1)C3(c2ccccc2)CCN(C(C)(C)C)CC3

InChI
InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3 
Key:QIHLUZAFSSMXHQ-UHFFFAOYSA-N 

  (verify)

While its exact mechanism of action is

not well characterized,[2] it is believed to
be an NMDA receptor antagonist,[4][5] but
also promoting the synthesis of
dopamine.[6]

Because it provides additional benefits

relative to existing treatments, it probably
does not precisely mimic the mechanism
of an existing known treatment.[6][7]

See also
AD-1211
Delucemine
Diphenidine
Ephenidine
Fluorolintane
Lanicemine
Methoxphenidine (MXP)
 MT-45
Remacemide

References
1. Martndale: The Complete Drug
Reference, 35th Ed.
2. Heinz Reichmann (October 2006).
"Budipine in Parkinson's tremor" .
Journal of the Neurological
Sciences. 248 (1–2): 53–55.
doi:10.1016/j.jns.2006.05.039 .
PMID 16784759 .
3. H. Przuntek; T. Müller (1999).
Clinical efficacy of budipine in
Parkinson's disease. Journal of
Neural Transmission. Supplementa.
56. pp. 75–82. doi:10.1007/978-3-
 7091-6360-3_3 . ISBN 978-3-211-
83275-2. PMID 10370903 .
4. J. Kornhuber, B. Herr, J. Thome, P.
Riederer. "The antiparkinsonian drug
budipine binds to NMDA and sigma
receptors in postmortem human
brain tissue". J.Neural
Transm.Suppl. 46:127-133, 1995.
PMID 8821048 .
5. Gene C. Palmer (September 2001).
"Neuroprotection by NMDA receptor
antagonists in a variety of
neuropathologies". Current Drug
Targets. 2 (3): 241–271.
doi:10.2174/1389450013348335 .
PMID 11554551 .
6. Przuntek H, Bittkau S, Bliesath H, et
al. (May 2002). "Budipine provides
additional benefit in patients with
Parkinson disease receiving a
stable optimum dopaminergic drug
regimen" . Arch. Neurol. 59 (5):
803–6.
doi:10.1001/archneur.59.5.803 .
PMID 12020263 . Archived from the
original on 2011-08-10. Retrieved
2008-08-04.
7. Jenny C.E. Owen; Peter S. Whitton
(October 2006). "Effects of
amantadine and budipine on
antidepressant drug-evoked
changes in extracellular dopamine
in the frontal cortex of freely moving
 rats". Brain Research. 1117 (1):
206–212.
doi:10.1016/j.brainres.2006.07.039
. PMID 16996043 .

This drug article relating to the nervous

system is a stub. You can help
Wikipedia by expanding it.

Retrieved from
"https://en.wikipedia.org/w/index.php?
title=Budipine&oldid=883585099"

Last edited 3 months ago by Citati…

Content is available under CC BY-SA 3.0 unless
otherwise noted.