Adapalene/benzoyl peroxide

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Adapalene/benzoyl peroxide

Combination of

Adapalene Retinoid

Benzoyl peroxide Peroxide

Clinical data

Trade names Epiduo

Pregnancy  US: C (Risk not ruled out)

category

Routes of Epicutaneous
administration

ATC code  D10AD03 (WHO), D10AE51(WHO)

Legal status
 Legal status  In general: ℞ (Prescription only)

Identifiers

CAS Number  1194805-81-6

KEGG  D10792

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Adapalene/benzoyl peroxide is a prescription medication combination for the treatment of

severe acne vulgaris; marketed by Galderma under the trade name Epiduo.[1] Its trade name in
Canada is TactuPump, where it was previously known as Tactuo.[2] It consists of a
combination of adapalene (0.1%) and benzoyl peroxide (2.5%) in a
topical gel formulation.[1] Meta-analysis of clinical trials has shown this combined therapy to be
more effective than either of its ingredients by themselves.[3]

Contents

 1Interactions
 2Side effects
 3Precautions
 4References
 5External links

Interactions[edit]
People are advised to exercise caution in using Epiduo together with other skin products
containing sulfur, resorcinol, or salicylic acid, or with medicated or
abrasive dirts and cleansers.[4] Skin products with high levels of alcohol or astringents should
also be avoided.[4] Using topical products with a strong drying effect in combination with Epiduo
can increase irritation.[4] The use of adapalene/benzoyl peroxide in combination with oral
antibiotics (lymecycline) has been studied;[5] the combination was well tolerated and showed an
improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P =
0.002).

Side effects[edit]
Commonly reported side effects include the following:[4]

 Skin redness
 Scaling
 Dry skin
 Contact dermatitis
 Skin irritation
 Stinging
 Burning
Precautions[edit]
People who use adapalene/benzoyl peroxide are advised to avoid exposure
to sunlight and sunlamps, and use sunscreenwhen these cannot be avoided.[4]