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Resume Interview Group 4
Resume Interview Group 4
Resume Interview Group 4
GROUP 4 :
A. BACKGROUND
Administration drug or drug delivery system can be devided into 5 ways. There are oral
administration, sublingual administration, intra venous administration, rectal administration, and
transdermal administration. Transdermal administration drug is a passive mode of drug delivery
through the skin into the bloodstream. This interview is used to know more information about
transdermal administration drug from pharmacist.
Elisabeth Hilda Wisda Putri or can be called Hilda is our interviewees. She was graduated from
Faculty of Pharmacy Universitas Gadjah Mada on 2014. Now she is continuing her study on Pharmacist
Profession Study Program at Faculty of Pharmacy Universitas Gadjah Mada. When she was studying on
Bachelor Program of Pharmacy, She chosen to specialize in the pharmaceutical industry so she knew how
to make a medicine and evaluate the quality of medicine.
We ask her some question about transdermal drug administration, there are :
The mechanism of penetration the drug into the skin starting from releasing the drug from the
base material and then the enhancer will help the drug to penetration through the skin. The drug will
move into bloodstream and the drug will spread throughout the body systematically.
The manufacture of transdermal dosage form must comply several conditions. The dose of the
drug each dosage form is must less than 20mg. The molecular weight is must less than 400 dalton.
This is because the pores of the skin is small so the drug must be small too. The aqueous solubility is
more than 1 mg/ml. This is because our blood contains a lot of water so the drug must dissolve so
that it can be circulated.
The advantage of transdermal administration is more practical than other administration. Beside
that, transdermal adimintration can avoid the drug from first pass metabolism so the dose of the drug
will remain and the patient can get the therapeutic effect more than other administration of drug.
The disadvantage of transdermal drug is patient the patient may get an allergic reaction because the
patch is attached to the skin.
There are three generation of transdermal drug administration. First the patch, how to use it by
attaching a patch on the skin then the drug will penetrate into the skin. Second the iontophoresis, it
uses low voltage to increase permeability of the skin. Third the microneedle, it uses a small needle
to penetrate the drug into the skin. The patches are easy to use but can cause allergic reactions. The
iontophoresis is requires electrical voltage so that the drug can penetrate into the skin. The
microneedle is more expensive than patches so it requires more costs for treatment.