A.

CELL DEATH/NECROSIS

COAGULATIVE NECROSIS LIQUEFACTIVE NECROSIS CASEATION NECROSIS ENZYMATIC FAT GANGRENOUS NECROSIS FIBRINOID NECROSIS
NECROSIS

CASE 1: (ACUTE CASE:(PYOGENIC LIVER CASE:(TB LYMPADENITIS) CASE: (ACUTE CASE 1:(SODT TISUE CASE: ( FIBRINOUS
MYOCARDIAL ABSCESS) PANCREATITIS) GANGRENE) PERICARDITIS)
INFARCTION)

6 year old poorly 35 year old male;eating 45 year old, diabetic 40 year old male;died of
10 year old boy;
48 year old obese male, developed male child died binge and drinking spree female, underwent AKA uremia sec to chronic
(+)multiple bilateral
(+)sudden onset of severe of septicemia. External during dinnertime.(+) for gangrene of the left renal disease.
cervical
crushing pain on the lest examination of the body severe epigastric pain; foot that has spread
lymphadenopathy;
anterior chest radiating to reveals multiple furuncles upwards to the shin.
CXR:PTB P.E.
the left shoulder, left arm in the lower extremity “BREAD and
and jaw. (+) guarding BUTTTER“ GROSS
(+)diaphoresis,nausea and APPEARANCE
vomiting. Pain persisted, (+)tenderness in the uppe
unrelieved by rest. EKG abdomen
-(+)ACUTE MI; died after 2
LAB:
days- CHF
(+)leukocytosis; Increase
serum amylase and lipase

Pt died post 2 days

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CASE 2: (PLACENTAL CASE 2:(GANGRENOUS
INFARCTION) APPENDICITIS)

35 year old female with 30 year old male;12 hours

pre-eclampsia who hx of vague abdominal
delivered a live baby girl. pain radiating to the RLQ
area:

(+)N/V

(+) temp. 38c

(+)RLQ tenderness

(+) Inc. Inflam markers

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MORPHOLOGY: MORPHOLOGY: MORPHOLOGY: MORPHOLOGY: MORPHOLOGY: MORPHOLOGY:

(contrast to coagulative (not a specific pattern of (not a specific pattern of (special form of necrosis-
A form of necrosis in necrosis) cell death) cell death) IMMUNE REACTION
(+) most often in foci of
which the architecture of involving BLOOD VESSELS
Characterized by tuberculous infection (+) Focal areas of aft Usually applied to a limb,
dead tissue is preserved.
DIGESTION of the DEAD destruction, typically generally lower leg taht Complexes of antigens and
CASEOUS- “cheese like”-
Tissue exhibit a firm CELLS- resulting in the resulting from a release has lost blood Ab are deposited in the
derived from the friable
texture. transformation of tissue in of activated pancreatic supply; undergone walls of the arteries.
appearance of the area of
to Liquid viscous mass lipase into the substance necrosis(coag necrosis)
Injury denatures not only necrosis Deposits of theses”
of the pancreas and the involving multiple tissue
the structural proteins (+) FOCAL IMMUNE COMPLEXES” +
MICROSCOPIC: peritoneal cavity. planes.
but also the enzymes - BACTERIAL/FUMGAL FIBRIN that has leaked out
and so block the INFECTIONS (+)structureless collection ACUTE PANCREATITIS- WET-GANGRENE of vessels=
proteolysis of the dead of fragmented/lysed cells pancreatic enzyme leak FIBRONOID( bright pink
(+)creamy yellow - (+)bacterial infection is
cells; RESULT: out of acinar cells and and amorphous
presence of PUS- dead (+) amorphous granular superimposed-
eosinophilic,anucleate liquefy the membranes of appearance in H&E
leukocytes debris enclosed within a liquefactive necrosis ;
cells persist for days/ fat cells in the peritoneum staining)
distinctive inflammatory the action of degenerative
weeks. (+) hypoxic death of cells
border- GRANULOMA FAT SAPONIFICATION- enzymes in the bacteria
within CNS
NECROTIC CELLS are fatty acid + calccium and the attracted
removed by produce grossly visible leukocytes.
PHAGOCYTOSIS of the chalky white areas
cellular debris

ISCHEMIA caused by
HISTOLOGIC EXAM-
OBSTRUCTION in a
VESSEL - may lead to Necrosis takes the form of
coagulative necrosis of the foci of shadowy outlines of
supplied tissue in all necrotic fats cells
organs EXCEPT the BRAIN.
(+)basophilic calcium
INFARCT- localized area of deposits surrounde by an
necrosis inflammatory reaction

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