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4248 Mflex Tubing Selection Guide
4248 Mflex Tubing Selection Guide
4248 Mflex Tubing Selection Guide
Application suitability†
Pressure
Advantages Sterilization
solvents
Vacuum
Alkalies
Organic
Viscous
formulation classifications permeability
Sterile
fluids
fluids
Acids
Silicone
(platinum-cured) Excellent biocompatibility. USP Class V Extractables
No leachable additives, DOP, or plasticizers; N/R N/R N/R F G F E Exceeds Class VI Implant
96410-, 96510-series phthalate and latex-free; odorless and nontoxic, European Pharmacopoeia (EP 3.1.9) CO2: 20,132
Sterilize by EtO,
fungus-resistant. FDA 21 CFR 177.2600; FDA 21 CFR 210 H2: 6579
autoclave, or
No taste imparted to transported fluids. and 211; Exceeds 3A sanitary cGMPs; O2: 7961
Temperature range: gamma irradiation.
Weather, ozone, corona, and radiation resistant. REACH (non-DEHP) compliant N2: 2763
Minimal tendency to take a set. Static: –50 to 230°C (–58 to 446°F) RoHS compliant
Translucent, clear to light amber. Dynamic (pumping): –40 to 100°C ADCF compliant
(–40 to 212°F)
Silicone
(peroxide-cured) Excellent biocompatibility.
N/R N/R N/R F G F E USP Class VI
No additives, plasticizers or DOP; odorless
European Pharmacopoeia (EP 3.1.9)
96400-, 96406-series and nontoxic, fungus-resistant. CO2: 20,132
FDA 21 CFR 177.2600
No taste imparted to transported fluids. H2: 6579 Sterilize by EtO or
Exceeds 3A sanitary standards
Weather, ozone, corona, and O2: 7961 autoclave.
Temperature range: REACH (non-DEHP) compliant
radiation resistant. N2: 2763
Static: –50 to 230°C (–58 to 446°F) RoHS compliant
Minimal tendency to take a set.
Dynamic (pumping): –40 to 100°C ADCF compliant
Translucent, clear to light amber.
(–40 to 212°F)
BioPharm Plus
Silicone Similar to BioPharm Silicone, plus:
(platinum-cured) Longest life of any silicone pump tubing. N/R N/R N/R F G F E USP Class VI
Lower spallation than regular silicone. European Pharmacopoeia (EP 3.1.9) CO2: 25,147
96440-, 96441-series Sterilize by EtO,
Enhanced pressure capability. FDA 21 CFR 177.2600 H2: —
autoclave, or
Fungus-resistant. Exceeds 3A sanitary standards O2: 4715
gamma irradiation.
Nontoxic, no leachable plasticizers. Temperature range: REACH (non-DEHP) compliant N2: 2284
Lower gas permeability than other silicones. Static: –60 to 232°C (–75 to 450°F) RoHS compliant
Translucent, clear to light amber. Dynamic (pumping): –40 to 100°C
(–40 to 212°F)
Biocompatible.
Puri-Flex™ Heat sealable and weldable.
Long pump life when compared to silicone G G N/R G G E E USP Class VI
Sterilize by EtO,
96419-series or other TPE tubings. FDA 21 CFR 177.2600 and CO2: 1200
autoclave up to
Low spallation when compared to silicone 177.1810 H2: —
135°C (275°F),
or some other TPE tubings. REACH (non-DEHP) compliant O2: 200
Temperature range: gamma irradiation
Very low protein binding. RoHS compliant N2: 80
Static: –50 to 135°C (–58 to 275°F) up to 4.5 Mrad.
Cost effective. ADCF compliant
No halogens or phthalates. Dynamic (pumping): –30 to 100°C
Translucent, clear to light white. (–22 to 212°F)
C-Flex®
Physical properties similar to silicone G G N/R F G F E
USP Class VI
06424-series with chemical compatibility of Tygon®. CO2: —
European Pharmacopoeia (EP 3.2.9) Sterilize by EtO,
Inexpensive. H2: —
REACH (non-DEHP) compliant autoclave, or
Biocompatible. O2: 150
Temperature range: RoHS compliant gamma irradiation.
Heat sealable and weldable. N2: —
Static: –45 to 121°C (–50 to 250°F) ADCF compliant
Opaque, white.
Dynamic (pumping): –40 to 100°C
(–40 to 212°F)
C-Flex® ULTRA
Physical properties similar to silicone G G N/R F G F E Sterilize by gamma
with chemical compatibility of Tygon®. USP Class VI
06434-series CO2: 2.1 irradiation or one
Biocompatible. European Pharmacopoeia (EP 3.2.9)
H2: — cycle of autoclave
Heat sealable and weldable. REACH (non-DEHP) compliant
O2: 1.1 at 121°C (250°F),
Longer pump life and lower spallation Temperature range: RoHS compliant
N2: 3.4 1 bar (15 psi) for
than C-Flex. Static: –45 to 121°C (–50 to 250°F) ADCF compliant
30 minutes.
Translucent. Dynamic (pumping): –40 to 100°C
(–40 to 212°F)
†E = Excellent, G = Good, F = Fair, P = Poor, N/R = not recommended
Pressure
solvents
Advantages Sterilization
Vacuum
Alkalies
Organic
Viscous
formulation classifications permeability
Sterile
fluids
fluids
Acids
Great for tissue and cell
PharMed® BPT work—nontoxic and nonhemolytic.
Long service life (up to 10,000 hrs); G G N/R G G E E USP Class VI
06508-series reduces tubing costs and pump downtime. European Pharmacopoeia (EP 3.2.9) CO2: 1200 Sterilize by EtO,
Opaque to UV and visible light to protect FDA 21 CFR 177.2600 H2: — autoclave, or
light-sensitive fluids. NSF-51 O2: 200 gamma irradiation
Low gas permeability. Temperature range: REACH (non-DEHP) compliant N2: 80 up to 2.5 Mrad.
High-pressure 10.3 bar (150 psi) version Static: –51 to 132°C (–60 to 270°F) RoHS compliant
available. Dynamic (pumping): –20 to 100°C
Opaque, beige (–4 to 212°F)
GORE® STA-PURE®
pump tubing N/R N/R N/R E G G E USP Class VI
Unique composite structure adds strength and
Series PCS (96211-) USP <87>
flex durability. Sterilize by
USP Physicochemical Tests
Greater security against rupture up to 100 psig*. — autoclave or SIP
Compliant with restricted
Consistent flow rate over long duration of use. (steam in place).
substances per REACH and RoHS
Withstands rigors of CIP/SIP processing. Temperature range: No raw materials of animal origin
Contact Cole-Parmer
GORE® STA-PURE®
pump tubing E E E E G G E USP Class VI
Unique composite structure adds strength and
Series PFL (96212-) USP <87>
flex durability. Sterilize by
USP Physicochemical Tests
Greater chemical resistance than Series PCS. — autoclave or SIP
Compliant with restricted
Stable flow rates achievable to 60 psig*. (steam in place).
substances per REACH and RoHS
Withstands rigors of CIP/SIP processing. Temperature range: No raw materials of animal origin
Contact Cole-Parmer
Chem-Durance® Bio
Excellent chemical resistance. E E G E E E E
Excellent life and durability under pressure.
06442-series USP Class VI CO2: 745
Low spallation. Sterilize by EtO,
FDA 21 CFR 177.2600 H2: —
Plasticizer-free inner liner. autoclave or
REACH (non-DEHP) compliant O2: 200
High dielectric constant. Temperature range: gamma irradiation.
RoHS Compliant N2: 80
Excellent biocompatibility. Static: –60 to 74°C (–71 to 165°F)
Opaque, beige. Dynamic (pumping): 0 to 40°C
(32 to 104°F)
Pressure
solvents
Vacuum
Advantages Sterilization
Alkalies
Organic
Viscous
formulation classifications permeability
Sterile
fluids
fluids
Acids
Longest life of all Tygon® peristaltic tubing.
Tygon® E-LFL Clear for easy flow monitoring. USP Class VI
G G N/R G G E G
Broad chemical resistance. European Pharmacopia (EP 3.2.9)
CO2: 563
06440-series Nonaging, nonoxidizing. FDA 21 CFR 175.300
H2: —
Sterilize by EtO or
Low gas permeability. EU Food autoclave.
Temperature range: O2: 124
Smooth bore. REACH (non-DEHP) compliant
Static: –46 to 74°C (–51 to 165°F) N2: 67
Good for viscous fluids. RoHS compliant
High dielectric constant. Dynamic (pumping): 0 to 40°C ADCF compliant
Transparent, clear. (32 to 104°F)
Viton®
before using