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CHOLECYSTOKININ vs SECRETIN

CHOLECYSTOKININ SECRETIN
Produced by: I cells (duodenum, jejunum) S cells (duodenum)
Effects on:
STOMACH DEC gastric emptying DEC gastric acid secretion
LIVER
GALLBLADDER INC gallbladder contraction INC bile secretion
INC sphincter of Oddi
relaxation
PANCREAS INC pancreatic secretion INC pancreatic HCO3–secretion
Works on Acinar cells of
Works on Ductal cells of the
pancreas
pancreas
Stimulated by: INC by fatty acids, INC by acid, fatty
amino acids acids in lumen
of duodenum
NOTES Acts on neural muscarinic INC HCO3– neutralizes gastric
pathways to cause pancreatic acid in duodenum, allowing
secretion.
pancreatic enzymes to
function.

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