Blood Group Ab Significant? | Ab Type Antigens Null/Weak Phenotypes Transfusion Reactions? | HDFN?

Notes
System
MNS M&N – No, IgM M, N, Ss U – blacks Anti-M,N – Rare, Rare GYPA & GYPB – contribute to RBC zeta potential
(002) S&U – Yes, IgG Mk – no MNSs Ag
En(a-) - GYPA and GYPB recombination Anti-S, s, and U – Yes, Yes GYPA – expression of band 3

Miltenberger type III cells – increased band 3

P P1 – No, IgM
(003 & 028)
Alloanti-PP1Pk – Yes, IgM+IgG
Alloanti-P – Yes, IgM
P1, P, Pk - Anti-P1 – No, No Anti-P1 – Increased in hydatid cyst dse., liver
fascioliasis
Alloanti-PP1Pk – Yes, Yes
Pk Ag – Marker for Burkitt’s lymphoma,
Alloanti-P – Yes, Yes Lymphoblastic leukemia; receptor for S. suis, P.
aeruginosa; HIV resistance

LKE – marker for renal cell and breast CA

metastasis
Lutheran Lua – No, IgM Lua, Lub - Increased in ovarian CA, sickle cell dse,
(005) facilitates tumor cell adhesion and metastasis
Lub – No, IgG Contributes to thrombosis in PV
Kell Alloantibodies – Yes, IgG K0K0 – lack of Kell Ag Alloantibodies -No, Yes McLeod cells – No kell Ag
(006 & 019)
Autoantikell - Yes Autoantikell – hemolytic anemia

Kell & ELE-1 – Cleaves endothelin 3

Lewis No, IgM Lea, Leb Le(a-b-) - Common in blacks and Lewis null – H. pylori, Norovirus resistance;
(007) children 5 years of age and lower Candida, heart disease susceptibility
Leab, LebH,
ALeb, BLeb sialyl-Lea – (if aberrant) contributes to tumor
metastasis; epitope of CA 19-9
Duffy Yes, IgG Fya, Fyb, Fy3, Fynull Yes, Yes DARC – P. vivax receptor, non in Fy null;
(008) Fy5, Fy6 increased renal transplant rejection
Low neutrophils in Africans

Fynull – survival advantage in HIV infection;

chronic organ damage in sickle cell dse.
Kidd Yes, IgG(IgG1 or IgG3) Jka, Jkb Jknull Yes, rare Jknull – RBCs resistant to 2M urea lysis
(009)
Diego Yes, IgG Dia, Dib, Wrb - Yes, Yes Expressed in the kidney
(010)
Cl- shift/Hamburger shift in Miltenberger type
III cells
 Cartwright No, IgG Yta, Ytb - Rare, No In PNH III, cells have no Yt Ag
(011)
Associated with shortened RBC survival
XG No, IgG Xga - -
(012)
Scianna Yes, IgG Sc1, Sc2, Sc3, Sc4 - Anti-Sc2, 4 – No, Yes Sc1 & Sc3 autoantibodies – warm autoimmune
(013) hemolytic anemia
Dombrock No, IgG DO1, DO2 DOnull Donull – observed in PNH III
(014)
Colton Yes, IgG COnull Yes, Yes Conull – Decreased urine conc., CO2
(015) permeability
LW No, IgG LWa, LWb - Rare, Rare LW – increased in sickle cell dse.; expression
(016) dependent on RhD

Chido/Rodgers No, IgG - Plasma Ag; Linked to autoimmune diseases

(017) (rheumatoid arthritis, Graves’ dse.)
Gerbich Usually, IgM or IgG Yus – Ge -2, 3, 4 No, Rare Gerbich incompatible transfusion – Shortened
(020) RBC survival, delayed hemolysis
Gerbich – Ge -2,-3, 4
Autoantibodies – severe autoimmune
Leach – Ge -2, -3, -4 hemolytic anemia

GYPC & GYPD – influenza resistance

GYPC – P. falciparum resistance

Cromer Yes, IgG CR1 Lnab Yes, No Present on DAF/CD55 – tissues and secetions;
(021) Expresed in cord RBCs and trophoblasts
DR(a-) - weak
lnab – chronic protein-losing gastroenteropathy

Cromer/CD55 – missing in PNH III RBCs;

protects cells from complement; Resistance to
E. coli, echovirus, coxackie B virus
Knops No, IgG - Resistance to rosette P. falciparum, Leishmania,
(022) Legionella, Mycobacterium
Indian Yes, IgG Ina, Inb - Yes, No Antibodies – shortened RBC survival
(023)
autoanti-AnWj – autoimmune anemia

Expressed in CD44
 H. influenzae resistance
OK No, IgG OKa Expressed in CD147 (participates in cell
(024) adhesion, tumorigenesis, wound healing,
leukocyte activation)

Anti-Oka – seen only in Japan

RAPH IgG RAPH/MER2 - Rare, No Seen in people with nephrotic syndrome with
(025) end-stage renal dse., and neurosensory
deafness

Expressed in CD151 (critical for basement

membrane assembly in the kidney and ear);
Binds complement
JMH IgG - SEMA7A – modulates T cells, monocytes, and
(26) NK cells; inhibits NK cell proliferation; negative
regulator of T cell activation; stimulates
chemotaxis, secretion of cytokines, and
dendritic cell maturation in monocytes

Antibodies can cause shortened RBC survival

I IgM I, i iadult – rare; associated with congenital
(027) cataracts

Increased i – cord RBCs, retics, megaloblastic

anemia, leukemia, chronic hemolytic states
(stressed erythropoiesis), HEMPAS

i antigen should decrease by 3 months of age

Adults – Increased I Ag, decreased i Ag

anti-I, i – can be seen in CAIHA; Susceptibility to

M. pneumoniae

Alloanti-I – rare, found in iadult individuals

(naturally occuring Ab)
Gil Yes, IgG Yes, No Reactive at 37° C and enhanced with AHG
(028) Decreased AQP3 is associated withdecreased
skin elasticity, poor wound healing, and eczema
Malaria and P. falciparum resistance