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  • Data Disolusi Higuchi

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    Khairunnisa Nisa
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    1. The document contains data from a dissolution test measuring the amount of drug dissolved over time (in minutes and hours) including concentration (Cp) and percentage dissolved. 2. A linear regression analysis was performed on the dissolution data based on the Higuchi model, showing a linear relationship between amount dissolved and the square root of time with an R2 value of 0.9628. 3. A calibration curve was constructed by measuring absorbance (Abs) values at different concentration levels of an active ingredient, showing a linear relationship between concentration and absorbance with an R2 value very close to 1.

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    1. The document contains data from a dissolution test measuring the amount of drug dissolved over time (in minutes and hours) including concentration (Cp) and percentage dissolved. 2. A linear regression analysis was performed on the dissolution data based on the Higuchi model, showing a linear relationship between amount dissolved and the square root of time with an R2 value of 0.9628. 3. A calibration curve was constructed by measuring absorbance (Abs) values at different concentration levels of an active ingredient, showing a linear relationship between concentration and absorbance with an R2 value very close to 1.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    8 views5 pages

    Data Disolusi Higuchi

    Uploaded by

    Khairunnisa Nisa
    1. The document contains data from a dissolution test measuring the amount of drug dissolved over time (in minutes and hours) including concentration (Cp) and percentage dissolved. 2. A linear regression analysis was performed on the dissolution data based on the Higuchi model, showing a linear relationship between amount dissolved and the square root of time with an R2 value of 0.9628. 3. A calibration curve was constructed by measuring absorbance (Abs) values at different concentration levels of an active ingredient, showing a linear relationship between concentration and absorbance with an R2 value very close to 1.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    of 5

    Data Disolusi

    t (menit) t (jam) t1/2 (jam) fp Abs Cp (mg/mL) Jumlah terdisolusi (mg) f


    0 0 0 0 0 0 0 0
    5 0.083333 0.2886751 1 0.084 -0.0006896552 -0.0172413793 -8.2759E-05
    10 0.166667 0.4082483 1 0.163 0.0047586207 0.1189655172 0.00048828
    15 0.25 0.5 2.5 0.214 0.0206896552 0.5172413793 0.00297103
    30 0.5 0.7071068 2.5 0.359 0.0456896552 1.1422413793 0.00845379
    45 0.75 0.8660254 4 0.529 0.12 3 0.02285379
    60 1 1 4 0.683 0.1624827586 4.0620689655 0.04235172
    90 1.5 1.2247449 5 0.538 0.1531034483 3.8275862069 0.06072414
    120 2 1.4142136 20 0.237 0.1972413793 4.9310344828 0.0843931
    180 3 1.7320508 20 0.282 0.2593103448 6.4827586207 0.11551034
    240 4 2 20 0.323 0.315862069 7.8965517241 0.15341379

    Data Disolusi Higuch


    18
    16
    14 f(x) = 9.7074026864x - 4.6631569146
    12 R² = 0.9628074781
    10
    8
    6
    4
    2
    0
    -2 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 2.2
    Jumlah total obat terdisolusi %Pelepasan obat Kumulatif % pelepasan obat
    0 0 0
    -0.0173241379 -0.008662069 -0.008662069
    0.1194537931 0.0597268966 0.0510648276
    0.5202124138 0.2601062069 0.3111710345
    1.1506951724 0.5753475862 0.8865186207
    3.0228537931 1.5114268966 2.3979455172
    4.1044206897 2.0522103448 4.4501558621
    3.8883103448 1.9441551724 6.3943110345
    5.0154275862 2.5077137931 8.9020248276
    6.5982689655 3.2991344828 12.2011593103
    8.0499655172 4.0249827586 16.226142069

    Disolusi Higuchi

    631569146
    Data Disolusi Higuchi
    Linear (Data Disolusi
    Higuchi)

    1.4 1.6 1.8 2 2.2


    Kurva Baku
    Kadar Cp
    (mg%) (mg/mL) Abs
    0.1 0.001 0.109
    0.2 0.002 0.123
    0.3 0.003 0.138
    0.4 0.004 0.337
    0.5 0.005 0.416 Kurva Baku
    0.6 0.006 0.516 0.16
    0.7 0.007 0.683
    0.14
    0.8 0.008 0.92 f(x) = 14.5x + 0.0943333333
    0.9 0.009 0.706 0.12 R² = 0.9996038035
    1 0.01 0.753 0.1
    0.08
    0.06
    0.04
    0.02
    0
    0.0005 0.001 0.0015 0.002 0.0025 0.003 0.0035
    Kurva Baku

    4.5x + 0.0943333333
    996038035
    Kurva Baku
    Linear (Kurva Baku)

    15 0.002 0.0025 0.003 0.0035


    Data Disolusi

    t (menit)

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