PREWIEW OF

TREATMENT
IN CUTANEOUS SCARS

BIODERMOGENESI®:
NON-INVASIVE SOLUTION FOR
STRETCH MARKS TREATMENT

“With the present study for the first time we found a real
restructuring of stretch marks in total absence of side effects.
The most important aspect certainly is the consistency of results,
which allows us to declare how they are absolutely replicable on
any subject as the working protocol is respected.”
A. Artigiani1, G. Cervadoro2, B. Loggini3, A. Paolicchi 4

(1) Clinica Dermosifilopatica, Università di Pisa

(2) Scuola di Specializzazione in dermatologia e Venerologia
U.O. Dermatologia Chirurgica, fisioterapica e follow-up ustioni, Università di Pisa
(3) Istituto di Anatomia Patologia III, Università di Pisa
(4) Clinica radiologia I, Università di Pisa

Scuola di Specializzazione in Dermatologia e Venereologia

U.O. Dermatologia Chirurgica, Fisioterapica e Follow Up Ustioni
Università di Pisa – Direttore Prof. Gregorio Cervadoro

PRESENTATION BY PIER ANTONIO BACCI
T
he evolution of knowledge requires ever great-
er attention to diagnosis and classification of
both diseases and situations of austerity. These
must also be considered all those imperfections that al-
ter the quality of life.
Like a scratch in a beautiful painting, stretch marks
ruin the look of young women and young men, in such
a way as to constitute a reason for reflection on the part
of the medical world.
In fact, more and more often these young people avoid
exposing their bodies and limit their social life, trying
to correct the stretch marks with all the possible solu-
tions, including the ones only supported by commercial
media campaigns and advertising without any scientific
validation.
To limit the visibility of the skin scars, dermatology
and aesthetic medicine have tried and proposed many
solutions with interesting studies and with significant
improvements, but always based on invasive methods.
We should thank to “Expo Italia” for the careful and
meticulous overhaul on stretch marks etiology in its
various forms and different stages, that made possible
to rethink about the oxygenation action, nourishment
3
activities and metabolic regeneration of the dermal,
epidermal and subcutaneous structure. These activities
are highly related to constitutional factors, endocrinol-
ogy and metabolism of the organism. This study began
more than ten years ago and was the basis of the perfec-
tion of Biodermogenesi® project, a new solution that was
born from consolidated knowledge and experiences in
cosmetic dermatology, sports medicine, physiotherapy
and phlebology.
The proposal that was made in 2005 to consider a new
non-invasive solution that would have replaced invasive
and therapeutic treatments for stretch marks, initially
left us perplexed. However, its preliminary views made
us understand that it was an opening of a new route,
which made us to reconsider and re-study the patho-
physiology and etiology of stretch marks. It especially
made us re-evaluate and understand better the impor-
tance of hypoxia, cellular toxemia, electromagnetic en-
ergy and physiotherapy.
Personally, this adventure impressed me, because it
was also perfectly in line with some thoughts that I em-
phasized in my studies on cellulite, on lipolymphedema
and aging but above all for the fact that imperfections
4

should always be considered real aesthetic diseases, es, including those that alter the appearance. Some of
which need a diagnosis, an interpretation and patho- these like wrinkles, cellulite, swollen legs, acne, alope-
physiological classification. cia, overweight, capillaries, pigmentation, localized fat,
This new methodology indeed was not created to tissue failure and stretch marks that, by themselves,
cancel the old methods, but to propose a new way per- constitute the most widespread and poorly-tolerated
fectly compatible with the new knowledge. Basically it imperfections: a proper aesthetics pathology.
is all about using every effort of tissue vascularization, Besides the undoubted scientific value and therapeu-
achieving the increase of blood velocity and a greater tic significance of the Biodermogenesi® method, I be-
oxygenation possibility, a tissue purification from those lieve that the point to understand is that this technique
toxins that block the ionic activities of the cells, the mi- has allowed all of us to revise important pages of bio-
tochondrial energy production and tissue regeneration, chemistry, biophysics, pathophysiology, anatomy, der-
and finally to a reduction in acidity and oxidative stress matology, endocrinology and clinical medicine, thus
of tissue. expanding our knowledge on the latest in regenerative
The proposal for a non-invasive method based on the medicine.
association of a partial vascularizing vacuum with a Biodermogenesi® is not a revolutionary nor a mirac-
particular electromagnetic stimulation applied directly ulous therapy. Instead, it is an intelligent and serious
to the energetic cellular activity, was taking again the application of pathophysiological knowledge and tech-
knowledge and experience already known in medicine. niques, with results that, within the limits of its possi-
In this way, we have a new therapy that in a synergistic bilities, are able to give satisfaction to a high percentage
way reverses the conceptual schemes of stretch marks, of patients who ask to smile again with non-invasive
making the treatment pleasant and well accepted by pa- methods.
tients, without imposing limitations in social life, and
even asks for exposure to the sun.
This new strategy, together with aesthetic results,
formed at that time a very useful tool for those who
were suffering from stretch marks, but also for those
who dedicated themselves to the study and research of
new therapeutic solutions.
Our first clinical observations, supported by focused
studies and biopsies, were then successfully demon-
strated and completed in several university centers and
clinics under the coordination of Professor Cervadoro
from Pisa University, with the realization of a huge
number of scientific studies that have finally gained
our method the recognition of the Italian Government
Agency for Innovation.
Biodermogenesi® constitutes an important innovation
and a serious non-invasive treatment for stretch marks,
for burn scar and tissue laxity, but it also represents a
real demonstration that all the imperfections should
never be considered as vanity, but as signals sent by our Pier Antonio Bacci
organism that want to say something is not working Head of Surgery in Maria Teresa Hospital in Florence
correctly in our body. Lecturer in the Master Aesthetic Medicine at the Uni-
Today, more and more we are able to get inside the versity of Siena, Pavia and Barcelona
structure of the cell, understand the biochemical and Professor of Aesthetic Surgery in the School of Surgery,
biophysical changes that are the basis of all diseas- University of Siena (93-11)

Patient burdened by dense and complex stretch
marks before and after 20 Biodermogenesi® ses-
sions in 2 months period with 2 cycles of tan. We see
a perfect filling and the subsequent tanning of the
stretch marks, which became hardly visible.
Archive Dr. P.A. Bacci - S. Frappi – Roma
5
Young patient of 16 years burdened by stretch marks,
which start from the plica of the buttocks and reach
until malleolus. The onset of stretch marks are due to
an intense cortisone therapy, some of which are al-
most two cm. wide. After a cycle of 16 Biodermoge-
nesi® sessions, we obtained the clear filling of striae,
which have leveled and became chromatically similar
to the surrounding skin.
Archive Dr. P.A. Bacci - S. Leonardi – Arezzo
6
BIODERMOGENESI®: NON-INVASIVE SOLUTION
AGAINST STRETCH MARKS TREATMENT
Materials and methods
The present study is an objective verification of the
effectiveness of Biodermogenesi® in the treatment of
stretch marks.
We have treated 18 patients, aged between 21 and 55
years, 13 subjects with skin phototype II and III and 5
subjects with skin phototype IV and V, all of whom had
stretch marks, ranging between 7 and 35 years, in dif-
ferent parts of body areas. The treatments were carried
out with a device called Bi-one® which then we adopt
official Biodermogenesi® protocols.
In the course of the sessions, together with Bi-one® de-
vice, we used synergistic cosmetics “Bi-one® step 1”, “Bi-
one® step 2”, “Bi-one® step 3”, “Bi-one® breast” and the
specific abrasive disposable sponge for peeling phase.
During the experimentation patients did not have
any other cosmetic, cosmetic medicine or dermatologi-
cal treatments of any kind nor used cosmetics for home
use. The research was subjected to prior approval by the
Ethics Committee competent, which had followed the
development of the scientific research.
Clinical evaluation
The evaluation on the outcomes of treatments was per-
formed by using biopsies and ultrasounds (Esaote Tech-
nos ultrasound MTX, LA probe 523 to 13 Mhz), aimed at
analyzing the following parameters:
Ecography at 13 MHz:
• evaluation of fibrosis induced by stria
Biopsy:
• evaluation of the stratum corneum
• evaluation of the basal membrane
• evaluation of the collagen fibers, elastic and orga-
nization of the dermis
These assessments were made at the beginning and
end of the program of the provided treatments. The
sampling points of the biopsies correspond to the cen-
ter of the stria, which is the place of maximum atrophy.
In a similar way, ultrasound probe was pointed at the
center of the stria, with measurements taken just before
the first and the last biopsies.
In light of the existing documentation about Bioder-
mogenesi®, it is already possible to demonstrate that this
method is able to revitalize and gradually fill the furrow
of the stretch marks (P.A. Bacci 2008/2010, R. Triola
2010), with a stable result at more than six years after
the end of the cycle of sessions.
With the analysis of biopsies we were able to docu-
ment definitively and without any lingering doubts the
real consistency of regeneration and reorganization of
the stria, with particular attention to the thickness of
the stratum corneum to the basal membrane and its re-
shaping and restructuring of the dermis.
It’s very important to state that the confrontation
with biopsies already presented during the conference
(P.A.Bacci, La Magra 2008) in which the anatomical
pathology showed a bland increase of collagen and
elastin, revascularization and a cellular hyperplasia,
was achieved after only two applications of Biodermo-
genesi® made in two days distance. From this study it
will be noticeable how the reorganization of the tissue
becomes strengthened even further, making it similar
to that found on normal skin where there is no sign of
stretch marks.
In all documented cases biopsies have focused on the
stratum corneum and its thickness, on the reorganiza-
tion of the basement membrane and the structure of the
dermis.
In the case histories relating to Biodermogenesi® it
was noticeable that the labrum of the stria tends to soft-
en, reducing the perception of fibrosis. Wishing to doc-
ument this aspect, we have looked for a replicable in-
strumental test that had already proved its worth in the
clinical literature in the analysis of fibrosis, although

related to other phenomena or diseases. Then we chose
echography, which is used to detect various forms from
fibrosis to cirrhosis or muscle injuries. The fibrosis, for
its particular rigid structure, determines a strong reflec-
tion to the acoustic wave (hyperechogenic area), leading
to the reading of the white area, generally clear, under
which determines a shadow cone, constituting an an-
echoic area . The more that fibrosis presents clear and rig-
id, the greater will be the reflection of the signal sound,
consequently looking darker below the cone. The eventu-
al regression of fibrosis leads to a smaller reflection of the
ultrasonic wave with a gradient shadow. In light of these
experiences, it was decided to adopt ultrasound value at
13 MHz (Esaote Technos model MTX probe LA 523), in
order to document if the fibrosis in the furrow of the stria
at the start of the cycle of treatments of Biodermogenesi®
is subject to variations or not.
Purpose of the work
This study aims to evaluate the effectiveness of Bio-
dermogenesi® in the field of stretch marks regeneration,
also in relation to skin type being treated. This work
is distinguished for the utilization of echography and
for making high number of biopsies. Therefore it is the
most extensive work ever carried out not only in sub-
stance of the study of Biodermogenesi®, but rather in the
general knowledge of altered physiology of the skin that
characterizes with the presence of stretch marks.
In contrast to other methods known in the state of the
art, Biodermogenesi® has a different approach to stretch
marks problems. For the first time, a comprehensive
balance of the treated tissue was obtained without caus-
ing preventive damage, which is the classic strategy
adopted by other methods that were confronted with
the theme of stria until today. In fact, previous propos-
als, from derma-abrasion to peeling treatment or vari-
ous techniques related to lasers, have always created a
damage, generally considered essential to encourage a
self-reparative action.
A careful reading of the pathophysiology of stretch
marks, especially if they are white colored and dated,
leads us to find the constant lack of two essential ele-
ments to achieve the restorative action: a good quality
7
of matrix and sufficient supply of oxygen.
As we have seen, old stretch marks are characterized
with local ischemia which causes a more pronounced
white color (remember that one of the factors that de-
termines the color of the skin is given by the light re-
flecting on red blood cells). Moreover, the excessive
thickening of the stratum corneum, which limits, if not
completely inhibits, the cutaneous transpiration. The
overall reduction in oxygen supply is therefore not ca-
pable of supporting any higher activity of the fibroblast
in the generation of new collagen.
Furthermore it is important to underline that dated
stretch marks are also characterized by a pearly white
coloring typical of a skin with rich of toxins. It is known
that toxin in the matrix acts as an insulater, consequent-
ly impoverishes the quality of matrix and slows down
the mobility of sodium (Na+) and potassium(K+), so re-
duce cell nourishment in the tissue with stretch marks.
The combination of reduced tissue oxygenation and
poor cellular nutrition that characterizes the skin with
stretch marks, makes us understand why the “philoso-
phy of damage” most of the time gives, in this specific
field of application, marginal and not always massively
replicable results against the stretch marks, with partic-
ularly limited effects on the pearly white colored stria.
However the synergy produced by Biodermogenesi®
has proven the ability to reduce the corneous layer of
the stria, reorganize hypodermis and dermis, regen-
erate progressively and re-vascularize the tissue. From
this study, we appreciated that the choice of the biocom-
patible electromagnetic field was the correct energy to
adopt. In fact electromagnetic field is able to determine
a calibrated thrust, in order to allow sodium and potas-
sium ions to surpass the increased resistance induced
by toxins present in dermis and consequently reactivate
the pumping action and nourish the skin cells and fi-
broblast adequately, favouring a greater regenerative
activity.
Biodermogenesi®
Biodermogenesi® is performed with a device named
BI-ONE®/BI-ONE® MD together with some synergistic
cosmetics.
8

Biopsies taken before and after 15 Biodermogenesi® sessions performed in 8 weeks (N.C., skin pho-
totype V, 52 years – Abdomen)

Biopsies taken before and after 20 Biodermogenesi® sessions performed in 9 weeks (C.P., skin pho-
totype II, 34 years – Abdomen)

Biopsies taken before and after 20 Biodermogenesi® sessions performed in 9 weeks and after 3
months of break 5 sessions in 2 weeks (R.E., skin phototype II, 35 years – Hips)
 9

Biopsies taken before and after 20 Biodermogenesi® sessions performed in 10 weeks (A.S., – skin
phototype IV, 45 years – Abdomen)

Biopsies taken before and after 20 Biodermogenesi® sessions performed in 9 weeks (D.M., skin pho-
totype III, 21 years – Breast)

Biopsies taken before and after 20 Biodermogenesi® sessions performed in 10 weeks (D.M., skin pho-
totype II, 27 years – Hips)
10
This method, already widely tested for over 4 years
for the treatment of striae, uses the combination of bio-
compatible type electromagnetic fields with the vacu-
um effect and the electrical stimulation square wave
frequency of 5 Hz, supplied at low intensity (max 3.5
VPP).
Clinical observations and studies conducted in the
past by Professor P.A. Bacci have demonstrated the effi-
cacy and the absence of complications on over 2000 pa-
tients in more than 25000 sessions. The treatment pro-
tocol is based on four stages of work: the first consists of
a scrub destined to reduce the thickness of the stratum
corneum and to allow a better cutaneous transpiration,
effectively using a disposable abrasive sponge; the sec-
ond phase is the application of electrical stimulation of
square wave at low intensity, with which it is intended to
vehicle the specially formulated active ingredients and
reactivate the lymphatic circulation of the skin, thanks
to the particular shape of the adopted probe and the ac-
tion of a series of AISI 304 steel balls that mechanically
stimulate the microcirculation, thereby promoting the
recovery of toxins present in the matrix. The third phase
is the heart of the treatment, where the combination of
vacuum and biocompatible electromagnetic fields allow
the increase of sodium / potassium pumping through
the intrinsic protein and water-soluble gates constituted
from precursors of amino acids, transforming the ki-
netic energy into thermal energy, so as to stabilize the
temperature of the dermis between 39 and 40° Celsius.
Alternating the polarity of the magnetic field creates an
interaction with sodium and potassium. With a signal
at positive charge, movement of sodium and potassium
is reactivated along the hydrophilic channels of the cell
membrane into the interior of the cells, promoting their
nourishment; varying the polarity of the signal creates
a strong attraction towards the same ions, which tend
to accelerate the normal action of rebalancing, thereby
returning them to the outside of the membranes and
detoxifying the cells. This phenomenon, consolidated
by over thirty years of clinical literature in the regen-
eration of muscle injury (diathermy and derivatives), in
Biodermogenesi® was calibrated in frequency in order
to work within the skin, avoiding the involvement of
deeper tissues. It is important to recall that this action
presents itself particularly interesting against the fibro-
blast, whose cell membrane is characterized by the high
number of hydrophilic channels. The induced action, to
be effective on the stria, cannot be separated from an
activity aimed at increasing blood flow inside the der-
mis.
To achieve this target, Biodermogenesi® has combined
the action of the electromagnetic field and vacuum that
are effective to reactivate a superior activity by the ar-
terial capillary of the skin, thereby preserving its in-
tegrity. Therefore, the pumping action of sodium and
potassium, combined with re-oxygenation of the tissue,
allows it to reactivate the fibroblast, ignite cell mitosis
and promote the capillarity of the stria, stabilizing pro-
gressive improvement of the esthetic problem. Lastly,
there is the fourth phase, in which, once again, a square
wave stimulation is adopted and permits, thanks to the
synergy given from a specific cosmetic, restoration to
normal hydrolipidic barrier and the physiological pH,
thus preventing any posthumous treatment limitations
to the patient. A very important point of this passage is
that we obtain the autonomy of physiological defenses
of the skin and at the same time we do not deflect the
energy and nutritional factors of the skin but leave them
aimed for maximum regeneration of the stria.
Conclusions
This study makes possible to identify serious factors
and results that are clear and constant on all treated pa-
tients, by revealing a new data linked to the skin type
of the patient that is subject to the Biodermogenesi®
treatment. The literature and documents existing until
were all based on patients with skin phototype I, II and
III. As we verify the results on patients with skin pho-
totype IV and V (five out of eighteen) after treatments,
we observed a faster and more evident response to the
treatment of Biodermogenesi® on all of them. Analyzing
the results obtained on ample cases reported in this pa-
per shows the echography answer is clearly sharper on
the skin phototype IV and V, like patient N.C. than the
skin phototype II and III, like patient D.M., although
N.C. is older than D.M. (52 years versus 21 years) and
has made a minor number of sessions. (N.C. 15 sessions
D.M. 20 sessions) This fact is also confirmed also from
biopsies, with particular reference to the restructuring
of the basal membrane, which we found to be generally
 11

Echography taken before and after 20 Biodermogenesi® sessions performed in 10 weeks present on the
abdomen of (A.S., skin phototype V, 45 years – Abdomen)

Echography taken before and after 20 Biodermogenesi® sessions performed in 9 weeks (D.M., skin
phototype II, 21 years – Breast)

Echography taken before and after 15 Biodermogenesi® sessions performed in 7 weeks (N.C., skin pho-
totype IV, 34 years – Abdomen)
12
better on patients with skin phototype IV and V.
After analyzing the details of the biopsy results, we
confirmed once again what was already proven in the
work of P.A. Bacci: skin regeneration. We observe a
consolidation of this phenomenon, where the deficits
that characterize the stria in some cases are complete-
ly eliminated, thereby restoring the skin to its original
state as it was before the onset of the imperfection. Stra-
tum corneum appeared in all pre-treatment biopsies to
be up to ten times higher than the normal parameters,
which is the reason of poor skin perspiration and con-
sequently reduced oxygenation. With this treatment,
stratum corneum tends to visibly normalize. From the
biopsies we see the basal membrane restructured, villus
are more evident and there is the presence of neo-me-
lanocytes, the elements that make stretch marks able to
get tanned by sunbathing naturally or artificially once
treated with Biodermogenesi®. We also see the restruc-
turing of the dermis, which before treatment appeared
to be compressed parallel to the corneum, as a conse-
quence of the alteration of collagen. After the Bioder-
mogenesi® treatment, there is a noticeable improvement
in the quality and quantity of collagen and elastic fibers,
protagonists of a general restructuring of the dermis,
which becomes very similar to the intact tissue.
The preliminary echography examination showed a
clear fibrosis on the furrow of the stria, while the test
carried out at the end of the treatment showed a reduc-
tion of fibrosis, which is strongly attenuated until dis-
appearing in some patients. The ecography diagnosis
confirms what already is evident to the touch, demon-
strating objectively as Biodermogenesi® is able to reverse
the superficial skin fibrosis. The most important aspect
is that results of this research are collimating and giving
evident improvements on all patients undergoing the
experimentation. We confirm that the main difference
we found in applying Biodermogenesi® is not in the re-
sult that you get, objectively the results were satisfactory
on all treated patients, but rather in the number of re-
quired sessions. In fact, in the 18 documented cases, in
which we have performed from a minimum of 15 to a
maximum of 25 sessions, we obtained a clear regression
of fibrosis, a filling of furrow and the reactivation of the
normal tan by exposure to ultraviolet rays.
In addition to the above-described instrumental eval-
uations, we interviewed patients at the end of treatment
and assessed the improvement in visual and tactile as-
pects. The subjective evaluation of the patients by ask-
ing the level of satisfaction on a scale of 0 to 100. The
average value of the satisfaction result of the patient was
85,83%, which is very high and in line with previous
data processed by P.A. Bacci, who had found the aver-
age satisfaction level of patients undergoing treatment
for Biodermogenesi®, determined on the same parame-
ters, to the value of 88.46%. The evaluation carried out
by our team is based rather on assigning a score relating
to various aspects that are visually and tactilely verifi-
able such as the rigidity of the labrum, depth, color and
opacity of the stria. The choice of these parameters is in-
tended to provide an evaluation as objective as possible
and not linked to the emotional impact of the obtained
result. Therefore we have given value of “0” to the con-
dition of stria before the start of the cycle of treatments,
considering the improvement obtained up to a maxi-
mum of 100, which corresponds to the total regenera-
tion of stria and its uniformity with the surrounding
intact skin tissue. The average value of improvement we
recorded on 18 patients was 83.55% with an attenuation
of the stria minimum of 72% (C.P., age 34, skin pho-
totype II, treatment area: abdomen), and a maximum
attenuation of 100% in two cases (EMC, age 41, skin
phototype IV, treatment area: abdomen) - (SA, age 45,
skin phototype V, treatment area: abdomen). It is con-
firmed that the dark skinned patients have a better and
faster response than white skinned patients. However,
it has been noted on a girl of white race an improve-
ment of 98%, even though we worked on a zone gen-
erally more difficult to treat and slower to react (MD,
age 21, skin phototype II, treatment area: breast). We
appreciated the system for assessing the difficulty level
of the stretch marks under the protocol that allowed us
to predict how many sessions would have been neces-
sary to obtain significant results. This tool has proved
trustworthy in the projection of the number of sessions
required and the duration of treatment. We have also
checked the predisposition to tanning of stretch marks,
with voluntary exposure to ultraviolet. To this optional
test submitted one patient with skin phototype IV and
thirteen patients with skin phototype II and III. The vi-
sual inspection carried out has revealed that all four-
teen patients obtained tanning in the furrow of stretch
marks, confirming what has been shown by all of the
 13

biopsies, demonstrating the significant presence of

neo-melanocytes context of an adequately reorganized
basement membrane.
We notice that pigmentation of the furrow of the
treated stria presents itself usually less evidently than
the surrounding intact skin, except in the case of DM
(age-21 - treated area: breast). In this case the patient,
residing in a seaside town, has had the opportunity to
be exposed to two cycles of tanning, getting a similar
color inside the stretch marks as in the adjacent tissue.
This difference is known to the state of the art, as it al-
ready occurred in the past. For example, for the scars
from an abrasion, where, with the new solar exposure,
is obtained a less level of tanning compared to intact
tissue, precisely by the action of regeneration obtained
inside the cutaneous alteration. In such cases the subse-
quent exposures usually allow you to uniform the color
of skin.
Of 280 Biodermogenesi® sessions we have not regis-
tered any side effects nor have the patients had any un-
desirable consequences. With the present study, for the
first time we found a real restructuring of stretch marks
in the total absence of side effects. The more relevant
aspect certainly is the uniformity of results, such that
lead us to state that these are definitely replicable on any
subject, provided they comply with the operative proto-
col of Biodermogenesi®.
The absolute absence of side effects and limitations
of the Biodermogenesi® treatment make an appropriate
21 years old patient with skin phototype II with white,
and interesting answer to the problem of stretch marks,
deep and opaque stretch marks present for more than
because it determines a real regeneration of the dermis 7 years. After Biodermogenesi® 20 sessions made in
acting exclusively accelerating the normal metabolic 9 weeks, it is clearly visible the improvement of the
functions, severely slowed down within the stria. striae, filled and leveled but also perfectly tanned and
became quite similar to the surrounding tissue.
(Archives of Dermatology School - University of Pisa)

A. Artigiani1, G. Cervadoro2, B. Loggini3, A. Paolicchi 4

(1) Clinica Dermosifilopatica, Università di Pisa
(2) Scuola di Specializzazione in dermatologia e Venerologia
U.O. Dermatologia Chirurgica, fisioterapica e follow-up ustioni, Università di Pisa
(3) Istituto di Anatomia Patologia III, Università di Pisa
(4) Clinica radiologia I, Università di Pisa
14
31 years old patient with skin phototype IV with stretch
marks older than 17 years on breasts. After 15 ses-
sions of Biodermogenesi® in 8-weeks, we can see the
regeneration and the filling of striae, which became
almost similar to the surrounding skin.
(Archives of Dermatology School - University of Pisa)
45 years old patient with skin phototype IV with white,
deep and opaque stretch marks, which are present
for more than 20 years, due to pregnancy. After 20
Biodermogenesi® sessions in 10 weeks it is perfectly
visible improvement in the stretch marks as they are
filled and leveled, which became very similar to the
surrounding tissue.
(Archives of Dermatology School - University of Pisa)
 15

WITH THIS STUDY, WE HAVE THE FOLLOWING PUBLICATION

La Medicina Estetica 2012 No. 1 January-March

Andrea Artigiani, Gregorio Cervadoro, Barbara
Loggini, Alessandro Paolicchi
Biodermogenesi®: The non-invasive solution for the
treatment of stretch marks – pp. 41/49
16
The follow-up has been the subject of publication on:
Hi.tech dermo - year VIII No. 5 - September / October 2013
FOLLOW-UP
P.A. Bacci -Treatment of striae distensae with
For the first time, Prof. P.A. Bacci presented Biodermo-
genesi® to the press on May, 8, 2008 at the press circle in
Milan. After five years Bacci presented at the XXXIV Na-
tional Congress of the Italian Society of Aesthetic Medi-
cine (Rome 10-11-12 May 2013) a work (Biodermogenesi®
Follow up at five years) that analyses the performance and
stability over time.
The study is conducted and documented in collab-
oration with Prof. A. Artigiani of Pisa University and
explains five years follow up of thirty patients.
The conclusions of follow-up are the followings:
Five years later
Five years after its inception organizing committee
of the project wanted to verify the results and possible
side effects of Biodermogenesi® in order to improve the
method and technique of treatment.
Initial sensations were evaluated with current infor-
mation. It is noted that the stretch marks smaller than
6:00 to 7:00 millimeters, are almost eliminated since
they are completely filled and they are no longer per-
ceived to the touch, except it is visible a whitish line on
the place of the stretch marks if the patient was not ex-
posed to the sun. In those medium sized stretch marks
an improvement and a reduction in visibility are ob-
tained, thanks also to an acceptable increase in the col-
oring of the skin, while the stria of a greater amplitude
from six-seven millimeters are filled, but remain less
dense to the touch compared to the surrounding tissue.
For the large stretch marks we recommend a second
cycle of treatments at least a distance of three months
from the first treatment, during which the difference
generally attenuates.
Thanks also to the collaboration with Prof. A. Arti-
giani of Pisa University, Dr. Calonzi of Rieti and our
physiotherapists in Arezzo and Rome center, Serena
Leonardi and Sabrina Frappi, it was possible to compare
the current state of the skin to its condition in 2008,
Biodermogenesi® - pp. 29/36
right after the end of Biodermogenesi® treatments.
During this follow up, this team reviewed and reana-
lyzed thirty patients.
The checked outcomes have shown continuous im-
provement and good stabilized results in time, without
the presence of side effects. In this way it was showing to
us that this non-invasive method may become the elec-
tive treatment for stretch marks because in contrast to
other invasive possible solutions, it allows the patients
to give the possibility to have a normal life without any
limitations such as sun exposure.
The results showed that some stretch marks are no
longer visible to the eye and the labrums appear flat-
tened and stay together. Striae is always filled and dif-
ficult to perceive to the touch. The skin complexion is
brighter no more opaque, more likely to pinkish intact
tissue, often resulting re-tanned on those who sunbaths
or expose to solar lamp.
Prof. A. Artigiani from the Department of Dermatol-
ogy of Pisa University analyzes the results of the five
years follow-up:
“We re-contacted 30 patients treated in 2008 with Bio-
dermogenesi® and we noted that, 5 years later, they have ex-
pressed positive opinions on the aesthetic result, for the fact
that stretch marks are not visible, they are no longer iden-
tifiable neither to the eye or to the touch, they are perfectly
filled and the color is very similar to the surrounding skin.
I should say that at the beginning I found a clear attenua-
tion of stretch marks, both to the touch and the eye, with an
important level of satisfaction of patients in the absence of
side effects. The same patients, 5 years later, have expressed
positive opinions on the aesthetic result with improvement
of the skin continued in the time. All this may suppose that
the reorganization induced by Biodermogenesi®, document-
ed by tens of biopsies, may be functional to the reactivation
of the normal metabolic processes, since the completion of
the cycle of sessions, perhaps will continue to operate as if
the stria was never been formed in that area. Certainly it’s
the opening of new frontier in the esthetic and medical es-
thetic field”.

37 years old patient of with stretch marks dating back
to the puberty period on lumbar region. Pictures tak-
en before and after 15 Biodermogenesi® sessions in
7 weeks and after more than 5 years of follow-up. At
the end of the treatment program, stretch marks are
filled but still partially visible. After the follow-up per-
formed after 5 years and a few months after the end
of treatment sessions, stretch marks appear invisible,
perfectly integrated with the surrounding skin tissue,
thanks to repeated sun exposure that have standard-
ized the skin color. Patient is recognizable with 4 spots
in the photographs.
(Archive Prof. A. Artigiani – Pisa)
17
26 years old patient with 10 years old stretch marks.
Pictures taken before and after 12 Biodermogenesi®
sessions in one month and after 5 years after the end
of treatment. Stretch marks, originally white and deep,
at the end of the sessions became filled but not yet
tanned. During follow-up, we appreciated the new-
found ability of stretch marks to tan, which allowed
the total harmonization of the imperfection with the
surrounding tissue.
(Archive Prof. A. Artigiani - Pisa)
18
THE EXPERIENCE OF DOCTOR J. VICTOR GARCIA
W
e have known Biodermogenesi® in 2009 as
the first non-invasive method that offers
the patient a safe and effective solution
against stretch marks and we presented in Spain in the
same year in XVII Jornadas Mediterráneas de Confront-
aciones Terapéuticas and at the Annual Course of our
Sociedad Española de Medicina y Cirugía Cosmética
(SEMCC).
We already knew the positive experience acquired by
Professor Pier Antonio Bacci, that today we confirm to-
tally the effectiveness and safety of Biodermogenesi®.
Furthermore we were also the first to introduce Bio-
dermogenesi® in Spain at our clinic in Barcelona.
Following a modest communication among our pa-
tients and in some magazines we had a strong interest
in the treatment beyond what we imagined, mainly by
women, but also men, who lived a strong discomfort for
their stretch marks.
Many of these patients had previously tried other
treatments in other clinics and quitted having treat-
ments because of poor results, serious side effects or for
the high cost.
We obtained, quick and very significant results, no-
ticeable from the third, fourth session without any side
effects for the patient, (neither during nor after the treat-
ment). We also observed the ability of stretch marks to
tan. In most cases we provided a preliminary session
of bio-stimulation with PRP, as we are traditionally the
precursors and enthusiastic defenders of this therapy.
We are extremely pleased to have this method in our
therapeutic proposal, because we learned to appreciate
all kind of methods that have solid basis: starting from
the knowledge of pathophysiology of stretch marks, we
learned how it is possible to diagnose an objective the
therapeutic treatment.
We really appreciated to have a technology that allows
an effective revascularization of the tissue to increase
blood flow and permits to obtain tissue oxygenation.
Consequently, we saw that all these actions induced by
Biodermogenesi® activate a purification of the skin by
removing toxins that block the necessary ion exchange,
energy production in the mitochondria and skin regen-
eration and permit to reduce the acidity and the local
oxidative status.
The knowledge of the protocols and experience accu-
mulated until now allowed us to open new horizons to
Biodermogenesi® such as skin aging, hypotonia of the
body and breast, scars and more.
This and the large quantity and quality of scientific
works that we received, confirm our clinical observa-
tions and open a long and bright future for Biodermo-
genesi®.
Dr. J. Víctor García
Presidente della Sociedad Española de Medicina y
Cirugía Cosmética - SEMCC
Co-Direttore del Máster di Medicina Cosmética,
Estética y del Envejecimiento Fisiológico della
Universidad de Barcelona
Co-Direttore della Cátedra UAB*-SEMCC di Gestión
del Conocimiento en Medicina del Envejecimiento
Fisiológico
 19

PREVIEW OF SCAR TREATMENTS

I
n November 2013, University of Pavia activated a 3 burn scars. The same patients were called for follow-up
study in its Interdepartmental Research Center after six months. During the follow up check, the team
“TAMe.Ri.CI” to document the effects of Bioder- of the experimentation examined and documented with
mogenesi® treatment method against cutaneous scars, photos the evaluation of the scars both from the clinical
with particular attention to post-surgical and burn scars. and instrumental point of view.
The objective of this study conducted by the Unit of Plas- At the end of 24 sessions, on all the scars we registered
tic Surgery was to document how Biodermogenesi® acts improvement, both for the clinical and instrumental as-
on scars by adjusting their thickness to the surrounding pect: better elasticity, less roughness, more uniform color
intact tissue, reduces fibrosis and attenuates the color dif- with the surrounding skin, reduction in brightness and
ferences between the intact skin and the scars. thickness. The best results were obtained on surgical
Instrumental tests conducted by the Department of scars, particularly hypertrophic ones.
Pharmaceutical Sciences evaluated the composition of The volunteers during the follow up after six months re-
the cicatricle tissue before and after the treatment pro- ported the maintaining of all the improvements achieved
gram, documenting qualitative and quantitative regen- with the treatment; these clinical observations were also
eration induced by Biodermogenesi® and reorganization confirmed with the instrumental evaluation.
action against various skin layers. The study was approved
by the Ethics Committee of the University based on pre-
liminary results obtained with Biodermogenesi® exactly
in the treatment of scars, some of which are shown below.
First documented cases in the treatment of stretch marks
showed how Biodermogenesi® was able to replicate the
regeneration already amply demonstrated against stretch
marks even in the context of scars opening new therapeu-
tic perspectives.
The attenuation of fibrosis, typical characteristic of
scars, their leveling and reducing color difference with the
surrounding tissue are of course obvious and clear results.
However, the best thing is that they don’t only represent
an aesthetic advantage, but also in many cases increase
the quality of life of patients.
The study was made on 20 volunteers divided into 2
groups and were treated for a total of 26 scars: 21 surgi-
cal, 2 resulting from healing by secondary intention and
20

Picture 1

Picture 2

Picture 1 - Echographies of the healthy tissue near the

scar (on left) and an abdominal scar (on right) before
Biodermogenesi® treatment (T0).
Picture 2 - Echography of the scar after 24 Biodermo-
genesi® sessions (T1).
The structural organization of new collagen fibers
“For the burn scars, there was a good response to the
production in the scar tissue takes the same image of
treatment from the aesthetic point of view but above all
healthy skin (absorption, refraction, light reflection).
from the functional point of view, here below a case of
(Archive University of Pavia) a volunteer patient: headache caused by muscle tension
given by the burn scar extended from jaw until the end of
the neck. The patient confirmed the total disappearance of
pain starting right from tenth session. The scar is consid-
erably softer and more elastic to the touch, consequently
the neck has a greater extension for to move and the skin
appears uniform to the surrounding healthy tissue.”

Professor Angela Faga

Director of the TAMERICI Center - Head of Research
Department
Professor in Plastic and Reconstructive Surgery at the
University of Pavia
Chief of the Master in Aesthetic and Wellness Medicine
- University of Pavia
 21

Patient with relevant and extensive scar that is partly 47 years old patient with post-surgical scar of 7 years
hypertrophic and partly hypertrophic, combined with old after 20 Biodermogenesi® sessions executed in
stretch marks and relaxation of gluteus. In 20 ses- two months. The keloid is fully regressed that linea
sions, stretch marks were filled and scar is consider- alba is once again visible. The scar is pigmented with
ably reduced. Furthermore, buttocks were remodeled sun exposure and has a color very similar to the sur-
as well, which looked much more compact and raised. rounding skin.
Both scar and stretch marks, exposed to the solar ray
(Archive Dr. P. Castellacci – Milano)
and pigmented, reaching a color similar to the sur-
rounding tissue.
(Archive Dr. F. Malatesta - Firenze
and Dr. A. Brafa - Siena)
22
BIODERMOGENESI® IS EFFICACIOUS AGAINST STRETCH MARKS
IN ANY PARTS OF THE BODY
36 years old patient burdened by stretch marks due to
pregnancy, which are present for more than 3 years.
The patient reacted particularly so well that in just 8
sessions showed a nearly complete regeneration of
stretch marks. We see also stretch marks tanned, as
the patient used sunlamps for few times.
(Archive Dr. C. Calonzi - Rieti)
White and deep stretch marks treated with 20 Bioder-
mogenesi® sessions in two months, checked after a
series of solar exposure. We see the perfect filling of
stretch marks leveled with the surrounding tissue and
the tanning of the same imperfection, as they became
almost invisible.
(Archive Dr. G. Alberti - Palermo)

Evident and important stretch marks before and af-
ter 20 Biodermogenesi®. From photos, we can see an
excellent result against striae, while treatment area is
more compact and elastic, also visible from the navel
and the abdominal folds.
(Archive Dr. Ş. Saraçoğlu – Istanbul)
23
Patient burdened by deep and opaque stretch marks
that cover the buttocks completely; after 20 Bioder-
mogenesi® executed in 2 months and the simulta-
neous exposure to the sun we can see the complete
regeneration of the striae, filled and perfectly tanned
and became very similar to the surrounding tissue.
(Archive Dr. C. Urbani – Roma)
24
42 years old patient with white, opaque and deep
stretch marks of more than 20 years, after a 10 Bio-
dermogenesi® made in a month, we see a perfect fill-
ing of striae, appearing leveled up to the surrounding
tissue and starting to get color with a first sun expo-
sure. At the same time, we can confirm the firming
and modeling of the treatment area.
(Archive Dr. D. Pirrottina - Milano)
30 years old patient burdened by stretch marks that
start from the nipple and radiate throughout the
breast. After 20 Biodermogenesi® sessions executed
in two months, we can appreciate the complete re-
generation of the striae, appearing perfectly integrat-
ed with the surrounding tissue, while the breast has
become even more harmonious and compact.
(Archive Dr. A. Reale - The Medical Care - Campobasso)

Stretch marks on the shoulder of a young man due to
intense physical activity. After 15 Biodermogenesi®
sessions made in 7 weeks and a series of solar expo-
sures, we obtained the regeneration of stretch marks
as we see a perfect filling and the subsequent tanning
of the same, which became hardly visible.
(Archive Dr. P.A. Bacci - S. Frappi - Roma)
25
Young man burdened by large stretch marks, still red
though older than 2 years. After one treatment pro-
gram with Biodermogenesi® stretch marks were per-
fectly regenerated and aligned with the surrounding
skin.
(Archive Beauty Blu - Firenze)
26
26 years old patient with evident stretch marks after
an intensive weight loss. Photos taken before and
after 20 Biodermogenesi® sessions executed in 2
months period. Besides the complete filling and tan-
ning of stretch marks, we see a real reshape of the
breasts, which are more compact and harmonious.
Text taken from: La Medicina Estetica, 2010, October/
December pag. 543/553
La Biodermogenesi® applicata al trattamento delle
smagliature
Roberta Triola, Emanuele Bartoletti, Carlo Alberto Bar-
toletti
Patient with stretch marks and remarkable skin sag-
ging prioblems on the lower part of abdomen. Photos
taken before and after 20 Biodermogenesi® sessions
executed in 8 weeks period. Here we appreciate an
important improvement on all abdomen area , which
is exteremely compact and tightened, while the na-
vel area had an incredible transformation. Moreover,
stretch marks are perfectly regenerated and uni-
formed with the surrounding tissue.
(Archive Beauty Medical Center – Milano)
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