TUGAS REVIEW ARTIKEL

OBAT TRADISIONAL INDONESIA

CINNAMOMUM BURMANII

Oleh :
ZHAFIRAH ALIFAH
NIM : 702016081

FAKULTAS KEDOKTERAN
UNIVERSITAS MUHAMMADIYAH PALEMBANG
2019
 REVIEW 1
1. Efek Senyawa Bioaktif Kayu Manis Cinnamomum burmanii Nees Ex.Bl.) Terhadap
Diabets Melitus
2. Cinnamomum Burmanii
3. Kayu Manis
4. Kulit kayu manis
5. Kulit kayu manis, bubuk kayu manis
6. Ekstrak etanol kayu manis dan daun kayu manis
7. Ekstrak etanol kayu manis
8. Ethanol dan air
9. Ethanol
10. Alkohol sinamat, kumarin, asam sinamat, sinamaldehid, antosinin dan minyak
atsiri dengan kandungan gula, protein, lemak sederhana, pektin dan lainnya.
11. Komponen mayor minyak atsiri yang terkandung pada daun Cinnamomum
burmanii adalah transsinamaldehid (60,17%), eugenol (17,62%) dan kumarin
(13,39%).
12. Ekstraksi kayu manis

13. Cinnamomum burmannii Blume yang banyak ditemukan di Indonesia

memiliki aktifitas antidiabetes. Ekstrak kulit batang atau daunnya berpotensi
dimanfaatkan untuk mengatasi DM tipe II yang ditandai dengan resistensi insulin dan
defisiensi insulin. Senyawa utama antidiabetesnya antara lain Methylhidroxy Calcone
Polymer (MHCP), sinamaldehid, dan polimer procyanidin type-A polymers atau
proanthocyanidin.
14. Emilda. 2018. EFEK SENYAWA BIOAKTIF KAYU MANIS Cinnamomum
burmanii NEES EX.BL.) TERHADAP DIABETES MELITUS.
(www.jurnal.farmasi.umi.ac.id/index.php/fitofarmakaindonesia )
 REVIEW 2

1. Toxicity Study of Antidiabetics Functional Drink of Piper crocatum and

Cinnamomum burmannii
2. Cinnamomum Burmanii
3. Kayu Manis
4. Dried bark of C. burmannii
5. Fresh cinnamomum Burmanii
6. Cinnamomum Burmanii extract
7. Cinnamomum Burmanii extract
8. Dried leaves of P. crocatum (10 g) were boiled in water (200 ml), Dried bark of C.
burmannii (20 g) were boiled in water (200 ml),
9. Biological assays. P. crocatum extract was mixed with the extract of C. burmannii
with a ratio of 1:0.6. Then, it was added the sweetener, stevia, as much as 0.67%
(v/v).
10. Flavonoid and tanin
11. Dried leaves of P. crocatum (10 g) were boiled in water (200 ml), and the process was
terminated when the volume reached up to 100 ml. Dried bark of C. burmannii (20 g)
were boiled in water (200 ml), and the process was terminated when the volume
reached up to 100 ml. The decoction was filtered through a Whatman no. 4 filter
paper and the resulting extract were used in the biological assays. P. crocatum extract
was mixed with the extract of C. burmannii with a ratio of 1:0.6. Then, it was added
the sweetener, stevia, as much as 0.67% (v/v).
12. The decoction was filtered through a Whatman no. 4 filter paper.
13. In conclusion, at the oral doses tested, the functional drink of P. crocatum and C.
burmannii was well tolerated and neither produced overt signs of clinical toxicity nor
any signs of hepato-, nephro or haematotoxicity. Thus, functional drink of P.
crocatum and C. burmannii was found to be non-toxic when oral repeated dose
toxicities were performed. Overall, this study provides valuable data on toxicity
profile of functional drink of P. crocatum and C. burmanii that should be useful for
the planning of future preclinical and clinical studies of the formulation.
14. Mega Safithri, Sedarnawati Yasni, Maria Bintang, Anna Setiadi Ranti. 2012. Toxicity
Study of Antidiabetics Functional Drink of Piper crocatum and Cinnamomum
burmannii. (http://journal.ipb.ac.id/index.php/hayati/article/view/4825/3285)

REVIEW 3

1. Antypiretic effect of Cinnamomum Burmanii (Nees & T.Nees) Blume Infusion in

Fever-induced Rat Models
2. Cinnamomum Burmanii dan Kayu Manis
3. Kayu Manis
4. Cinnamomum barks
5. Dried twigs cinnamomum (infusion)
6. Infusa cinnamomum Burmanii
7. Infusa cinnamomum Burmanii oral
8. Cinnamaldehyde
9. Cinnamaldehyde extract
10. Cinnamaldehyde, a chemical constituent of cinnamon which has inhibitory effect on
secretion of endogenous pyrogen may not be sufficient enough to fully inhibit release
of endogenous pyrogens, COX and the prostaglandins. Therefore, a further research
should be conducted on Cinnamomum burmannii (Nees & T. Nees) Blume using
other methods of extracting the active compound which possibly result in higher
concentration of cinnamaldehyde, thus will increases its effectiveness.

11. The cinnamon barks were measured into suitable weight of 0.15 g, 0.30 g and 0.60 g.
Water is heated in the first level pot until it is boiled and cinnamon barks mixed with 5
mL of water were placed at the second level pot, heated until 90°C for 15 minutes
with every 5 minutes the preparation is stirred.
12. The preparation was then filtered using a flannel cloth and adding hot water through
the pulp until the needed volume was obtained. The filtrate had a brown to dark
brown colour varying according to the different concentrations. Herbal infusion of
Cinnamomum burmannii (Nees & T.Nees) Blume was kept in a container until the
time of treatment.

13. It can be concluded that 5 mL of 6% and 12% Cinnamomum burmannii (Nees &
T.Nees) Blume infusion per oral had antipyretic effect for the first 30 minutes.
Additional studies are needed to determine if the antipyretics effects of cinnamon
were due to inhibitory effect of cinnamaldehyde on secretion of endogenous
 pyrogens, and compared with gold standard antipyretics example paracetamol to see
whether there was a significant difference in antipyretic effect between cinnamon and
paracetamol. The research also should be developed into clinical trial and lastly
expanded into phytopharmaca.

14. Qatrunnada Zainol, Eva M. Hidayat, Stanza Uga Peryoga. 2014. Antipyretic Effect of
Cinnamomum burmannii (Nees & T.Nees) Blume Infusion in Fever-induced Rat
Models (http://journal.fk.unpad.ac.id/index.php/amj/article/view/352)
REVIEW 4

1. Efek Kayu Manis (Cinnamomum burmannii) Terhadap Kadar Glukosa Darah

Postprandial
2. Cinnamomum Burmanii
3. Kayu Manis
4. Cinnamomum Burmanii
5. Kayu manis
6. Bubuk kayu manis
7. Eksperimental
8. Sinamaldehida
9. Sinamaldehida
10. Kandungan dalam kayu manis yang dapat menurunkan kadar glukosa darah ialah
sinamaldehida. Sinamaldehida bekerja menghambat enzim alfa glukosidase. Enzim
ini merupakan enzim yang terdapat pada brush border usus halus dan bertugas
memecah polisakarida dan disakarida menjadi glukosa. Senyawa lain dalam kayu
manis yang dapat menurunkan kadar glukosa darah yaitu MHCP, suatu flavonoid
yang memiliki efek mirip insulin. Kerja MHCP antara lain ialah dengan
meningkatkan konsentrasi IRS-1, suatu reseptor insulin yang akan mengaktifkan jalur
PI-3K.
11. Subjek penelitian diberi 100 gram puding nasi tanpa kayu manis yang dimakan dalam
waktu lima menit.
12. Alat yang digunakan berupa glukometer, strip glukometer, lanset derngan lancing
device, kapas alkohol 70%.
13. Kayu manis menurunkan kadar glukosa darah postprandial.
14. (https://repository.maranatha.edu/12183/10/1010066_Journal.pdf)
REVIEW 5

1. UJI EFEKTIVITAS KULIT BATANG KAYU MANIS (Cinnamomum burmanii)

TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN
GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI SUKROSA
2. Cinnamomum Burmanii
3. Kayu Manis
4. Kulit batang pohon kayu manis
5. Tanaman kayu manis
6. Ekstrak etanol kulit batang kayu manis
7. Metode maserasi
8. Etanol 80%
9. Suspense ekstrak etanol
10. Flavonoid

11. Dosis yang diberikan pada tikus 1,26 g/200gBB (KP1), 2,52 g/200gBB (KP2) dan
5,04 g/200gBB (KP3).

12. Alat-alat gelas (Pyrex), timbangan digital, kertas saring, alumunium foil, vacum
evaporator, ayakan mesh 200, oven, Nasogastrictube (NGT) no.5, disposable syringe
3 mL, gunting, alat ukur gula darah (Easy Touch Multy Check) dan advantage test.

13. Ekstrak etanol kulit batang kayu manis (Cinnamomum burmanii) dapat menurunkan
kadar gula darah tikus putih jantan galur wistar yang diinduksi sukrosa dan Ada
hubungan antara peningkatan konsentrasi ekstrak etanol kulit batang kayu manis
(Cinnamomum burmanii) dengan penurunan kadar gula darah tikus putih jantan galur
wistar dimana semakin tinggi variasi dosis yang diberikan semakin memberikan efek
penurunan kadar gula darah yang lebih baik.
14. Gabriella Alusinsing, Widdhi Bodhi, dan Sri Sudewi. 2014. UJI EFEKTIVITAS
KULIT BATANG KAYU MANIS (Cinnamomum burmanii) TERHADAP
PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR
 WISTAR (Rattus norvegicus) YANG DIINDUKSI SUKROSA
(https://ejournal.unsrat.ac.id/index.php/pharmacon/article/view/5453)

REVIEW 6

1. PEMANFAATAN MINUMAN SERBUK INSTAN KAYU MANIS (Cinnamomum

burmanii BI.) UNTUK MENURUNKAN KADAR KOLESTEROL TOTAL DARAH
PADA TIKUS PUTIH (Rattus norvegicus)
2. Cinnamomum Burmanii
3. Kayu Manis

4. Kulit kayu manis

5. Kulit kayu manis

6. Minuman serbuk instan kayu manis

7. Rebusan

8. Air dan alcohol 70%

9. Ekstrak

10. Alkaloid, flavonoid, tanin, dan minyak atsiri yang terdiri dari kamfer, safrol,
eugenol, sinamaldehid, sinamilasetat, terpen, sineol, sitral, sitronelal, polifenol dan
benzaldehid

11. Minuman serbuk instan sebanyak 14,4 mg/5,15 ml/hari, 43,2 mg/5,15 ml/hari,

12. Erlenmeyer, gelas beker, gelas ukur, gelas pengaduk, pipet ukur, flow pipet,
oven, timbangan analitik, blender, penyaring, sentrifuge, kompor, panci, sendok
pengaduk, plastik, nampan, baskom, chopper, kandang tikus, gavage needle, spuit
injeksi, mikrohematokrit, tabung ependorf, gunting, sarung tangan plastik, kertas label
dan masker.
13. Pemberian minuman serbuk instan kayu manis selama 7 hari dapat
menurunkan kadar kolesterol total darah pada tikus. 2) Konsentrasi minuman serbuk
instan kayu manis yang paling banyak menurunkan kadar kolesterol total darah tikus
adalah pemberian dengan konsentrasi 43,2 mg/5,15 ml, dengan penurunan kolesterol
sebanyak 7,8 mg/Dl

14. (http://e-journal.uajy.ac.id/5385/1/JURNAL.pdf)