Antipsychotic Pearls

Antidepressant Pearls
Sexual QTc Serotonin Syndrome
Class Dysfunction Prolongation Risk GI Sedating Anticholinergic

SSRI yes yes yes Diarrhea (sertraline), Agent specific, Minimal

(citalopram highest) paroxetine (constipation) usually not (except Paroxetine)
significant

SNRI yes Generally yes GI upset possible Generally no no

not relevant

Bupropion no Generally no GI upset possible, combo No, no

not relevant for weight loss activating

Mirtazapine no Generally Generally Weight gain yes Minimal

not relevant not relevant (antihistamine)

TCA yes yes yes Constipation yes yes

MAOI yes Generally yes GI upset possible yes Possible

not relevant

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