DRUG INDEX_Siblang

TRADE NAME GENERIC CLASSIFICATION DOSAGE MECHANISM OF ACTION INDICATIONS ADVERSE REACTION
Duvadilan Isoxsuprine HCl Peripheral Vasodilator 3 amps Isoxsuprine isoxsuprine increases muscle blood flow, but skin Pre-term labor Cardiovascular: Hypotension, tachycardia,
x 20 gtts/min to blood flow is usually unaffected. Rather than chest pain
titrate at increasing muscle blood flow by beta-receptor Central nervous system: Dizziness
stimulation, isoxsuprine probably has a direct action Dermatologic: Rash
increments of 5
on vascular smooth muscle. The generally accepted Gastrointestinal: Nausea, vomiting
gtts/min until mechanism of action of isoxsuprine on the uterus is Neuromuscular & skeletal: Weakness
uterine contraction beta-adrenergic stimulation. Isoxsuprine was shown
ceases provided to inhibit prostaglandin synthetase at high serum
BP not <90/60; CR concentrations, with low concentrations there was
>110 bpm an increase in the P-G synthesis.
Indomethacin NSAID Inhibits prostaglandin delay premature Peptic ulcers Indomethacin NSAID
Readily crosses the labor, reduce Other common gastrointestinal complaints, including
placenta and can amniotic fluid in dyspepsia, heartburn and mild diarrhea
reduces fetal urine polyhydramnios, and Many NSAIDs, but particularly indomethacin, cause
production (reducing to close patent ductus lithium retention by reducing its excretion by the
renal blood flow and arteriosus kidneys. Thus indomethacin users have an elevated
increasing renal Also an effective risk of lithium toxicity.
vascular resistance, tocolytic agent, able > reduces plasma renin activity and aldosterone
possibly by enhancing to delay premature levels, and increases sodium and potassium
the effects of labor by reducing retention. It also enhances the effects of
vasopressin on the uterine contractions vasopressin. Together these may lead to:
fetal kidneys)  edema (swelling due to fluid retention)
 hyperkalemia (high potassium levels)[2]
 hypernatremia (high sodium levels)
 hypertension (high blood pressure)
- cause elevations of serum creatinine and more
serious renal damage such as acute renal failure,
chronic nephritis and nephrotic syndrome. These
conditions also often begin with edema and
hyperkalemia.
Duphaston Dihydrogesterone Progesterones 1 tab TID similar to endogenous progesterone in Irregular duration of cycles gastro-intestinal disturbances, allergic
without estrogens. molecular structure and pharmacological and irregular occurrence and skin rashes or urticaria, changes in
effect. It therefore has a high affinity for duration of periods caused libido, acne, fluid retention, mass gain,
progesterone receptors. It has no androgenic by progesterone deficiency. mental depression and breast changes,
effects (hirsutism, voice changes, acne, etc.) Combined with an estrogenic which may include discomfort or
in the mother and no masculinizing effect on substance, Duphaston can gynaecomastia
the female fetus, even in high doses and be applied in secondary
prolonged treatment. amenorrhoea, dysfunctional
uterine bleeding and post-
menopausal complaints
where endogenous
progesterone deficiency is
implicated.

Junior MACKY TIU