7/19/2019 Tracrium (atracurium) dosing, indications, interactions, adverse effects, and more

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atracurium (Rx)
Brand and Other Names: Tracrium
Classes: Neuromuscular Blockers, Nondepolarizing

Dosing & Uses

Adult Pediatric

Dosage Forms & Strengths

injectable solution

10mg/mL

Endotracheal Intubation, Mechanical Ventilation

Calculate dose based on ideal body weight

0.4-0.5 mg/kg IVP over 60 seconds, then 0.08-0.1 mg/kg 20-45 minutes after initial dose to
maintain neuromuscular block, repeat maintenance dose q15-25min PRN OR

Continuous infusion: 0.005-0.01 mg/kg/min IV (ranges from 0.002-0.015 mg/kg/min) OR

0.2-0.4 mg/kg IVP if following succinylcholine for intubation

Skeletal Muscle Relaxation During Surgery

0.4-0.5 mg/kg IVP over 60 seconds, then 005-010 mg/kg/min; block usually maintained at rate of
0.011-0.013 mg/kg/min

Renal Impairment

Dose adjustment not necessary

Hepatic Impairment

Dose adjustment not necessary

Administration

Reduce dose if given with general anesthetics that potentiate its activity (eg, isoflurane)

Dosage Forms & Strengths

injectable solution

10mg/mL

https://reference.medscape.com/drug/atracurium-343103 1/2
7/19/2019 Tracrium (atracurium) dosing, indications, interactions, adverse effects, and more

Endotracheal Intubation, Mechanical Ventilation

<1 month old: Safety and efficacy not established

1 month - 2 years: 0.3-0.4 mg/kg IVP under halothane anesthesia

Maintenance dose: Children may need more frequent maintenance doses than adult

>2 years: 0.4-0.5 mg/kg IVP over 60 seconds, then 0.08-0.1 mg/kg 20-45 minutes after initial dose
to maintain neuromuscular block, repeat maintenance dose q15-25min PRN

https://reference.medscape.com/drug/atracurium-343103 2/2