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    Benign Prostatic Hyperplasia Pathophysiology

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    Darla Sauler
    Benign prostatic hyperplasia (BPH) is influenced by both non-modifiable factors like age, gender, and heredity, as well as modifiable factors like diet, smoking, and inflammation. As testosterone is converted to dihydrotestosterone, the prostate gland enlarges due to hyperplasia of the smooth muscle within. This obstructs the urethra and bladder outlet, making urination difficult and increasing risks like urinary tract infections if left untreated.

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    Benign Prostatic Hyperplasia Pathophysiology

    Uploaded by

    Darla Sauler
    1K views2 pages
    Benign prostatic hyperplasia (BPH) is influenced by both non-modifiable factors like age, gender, and heredity, as well as modifiable factors like diet, smoking, and inflammation. As testosterone is converted to dihydrotestosterone, the prostate gland enlarges due to hyperplasia of the smooth muscle within. This obstructs the urethra and bladder outlet, making urination difficult and increasing risks like urinary tract infections if left untreated.

    Original Description:

    Pathophysio of BPH

    Original Title

    136229354 Benign Prostatic Hyperplasia Pathophysiology

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    Benign prostatic hyperplasia (BPH) is influenced by both non-modifiable factors like age, gender, and heredity, as well as modifiable factors like diet, smoking, and inflammation. As testosterone is converted to dihydrotestosterone, the prostate gland enlarges due to hyperplasia of the smooth muscle within. This obstructs the urethra and bladder outlet, making urination difficult and increasing risks like urinary tract infections if left untreated.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    1K views2 pages

    Benign Prostatic Hyperplasia Pathophysiology

    Uploaded by

    Darla Sauler
    Benign prostatic hyperplasia (BPH) is influenced by both non-modifiable factors like age, gender, and heredity, as well as modifiable factors like diet, smoking, and inflammation. As testosterone is converted to dihydrotestosterone, the prostate gland enlarges due to hyperplasia of the smooth muscle within. This obstructs the urethra and bladder outlet, making urination difficult and increasing risks like urinary tract infections if left untreated.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 2

    Benign Prostatic Hyperplasia

    Non modifiable factors: Modifiable factors:

    - Gender - Heart disease risk factors


    - Age - Effects of chronic inflammation
    - Heredity - Diet
    - Socio-economic factors - Sexual activity
    - race - smoking

    Decreased testosterone
    conversion by 5 alpha
    reductase

    Increased dihydrotestosterone

    Prostate gland
    hyperplasia

    Hypertrophy of smooth muscle

    Increased tissue Increased muscle tone at


    constricting the lumen bladder neck and prostate
    urethra

    Urinary obstruction
    Increase strength of
    the detrussor muscle
    contraction Further growth of
    prostate gland angiogenesis

    Effective bladder
    evacuation Exacerbation of
    urethral obstruction
    Success/relief (temporary)
    Detrussor muscle
    becomes overwhelmed

    Decrease in force of urinary Detrussor muscle exerts


    stream, feelings of an overactive contraction
    incomplete bladder
    increase daytime voiding
    emptying despite urination
    frequency, nocturia,
    Urge incontinence
    urgency

    Prostate enlargement
    During urination
    continues
    (dysuria), straining is
    present due to
    obstruction of urine flow
    Bladder outlet
    obstruction

    Breaks on blood vessels

    Decompensating
    hematuria
    detrussor muscle

    Acute urinary retention

    Incomplete bladder Renal failure Bladder rupture


    emptying

    Peritonitis
    Uremia
    UTI

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